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Tytuł :
Parkinson's disease following COVID-19: causal link or chance occurrence?
Autorzy :
Li WS; National Neuroscience Institute, Duke NUS Medical School, Outram road, Singapore, 169608, Singapore.
Chan LL; National Neuroscience Institute, Duke NUS Medical School, Outram road, Singapore, 169608, Singapore.
Chao YX; National Neuroscience Institute, Duke NUS Medical School, Outram road, Singapore, 169608, Singapore.
Tan EK; National Neuroscience Institute, Duke NUS Medical School, Outram road, Singapore, 169608, Singapore. .
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Źródło :
Journal of translational medicine [J Transl Med] 2020 Dec 29; Vol. 18 (1), pp. 493. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Case Reports; Letter; Review
MeSH Terms :
SARS-CoV-2*
COVID-19/*complications
Parkinson Disease/*complications
Adult ; Causality ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/diagnosis ; Parkinson Disease, Secondary/diagnosis ; Parkinson Disease, Secondary/etiology ; Time Factors ; Translational Medical Research
Recenzja
Tytuł :
Parkinson disease and the gut: new insights into pathogenesis and clinical relevance.
Autorzy :
Travagli RA; Department of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA, USA. .
Browning KN; Department of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA, USA.
Camilleri M; Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, MN, USA.
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Źródło :
Nature reviews. Gastroenterology & hepatology [Nat Rev Gastroenterol Hepatol] 2020 Nov; Vol. 17 (11), pp. 673-685. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Brain/*physiopathology
Gastrointestinal Microbiome/*physiology
Gastrointestinal Tract/*physiopathology
Parkinson Disease/*physiopathology
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/adverse effects ; Animals ; Disease Models, Animal ; Enteric Nervous System/physiopathology ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/microbiology ; Gastrointestinal Diseases/therapy ; Gastrointestinal Tract/innervation ; Gastrointestinal Tract/microbiology ; Humans ; Neurotoxins/adverse effects ; Oxidopamine/adverse effects ; Parkinson Disease/etiology ; Parkinson Disease/therapy ; Parkinson Disease, Secondary/chemically induced ; Parkinson Disease, Secondary/microbiology ; Parkinson Disease, Secondary/physiopathology ; Pesticides/adverse effects
Czasopismo naukowe
Tytuł :
Association of autonomic symptoms with cerebrospinal fluid biomarkers in Parkinson disease and scans without evidence of dopaminergic deficit.
Autorzy :
Yu Z; Beijing Neurosurgical Institute, Capital Medical University.
Li Y; Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
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Corporate Authors :
and the Parkinson's Progression Markers Initiative
Źródło :
Medicine [Medicine (Baltimore)] 2021 Feb 19; Vol. 100 (7), pp. e24837.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers/*cerebrospinal fluid
Dopamine/*deficiency
Parkinson Disease/*diagnostic imaging
Parkinson Disease/*metabolism
Aged ; Amyloid beta-Peptides/cerebrospinal fluid ; Autonomic Nervous System/physiopathology ; Autonomic Nervous System Diseases/cerebrospinal fluid ; Autonomic Nervous System Diseases/diagnosis ; Autonomic Nervous System Diseases/physiopathology ; Body Temperature Regulation/physiology ; Case-Control Studies ; Female ; Gastrointestinal Diseases/metabolism ; Humans ; Male ; Middle Aged ; Parkinson Disease/cerebrospinal fluid ; Parkinson Disease/physiopathology ; Primary Dysautonomias/etiology ; Severity of Illness Index ; Surveys and Questionnaires ; Urologic Diseases/metabolism
Czasopismo naukowe
Tytuł :
Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease.
Autorzy :
Kandil EA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Sayed RH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Ahmed LA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Abd El Fattah MA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
El-Sayeh BM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
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Źródło :
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2019 Dec; Vol. 46 (12), pp. 1141-1150. Date of Electronic Publication: 2019 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
Parkinson Disease*/drug therapy
Parkinson Disease*/genetics
Parkinson Disease*/pathology
Albendazole/*pharmacology
Hypoxia-Inducible Factor 1, alpha Subunit/*genetics
Neuroprotection/*drug effects
Neuroprotection/*genetics
Nuclear Receptor Subfamily 4, Group A, Member 2/*genetics
Albendazole/therapeutic use ; Animals ; Behavior, Animal/drug effects ; Cell Death/drug effects ; Cell Death/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Disease Models, Animal ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/physiology ; Gene Expression Regulation/drug effects ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Male ; Molecular Targeted Therapy ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Nuclear Receptor Subfamily 4, Group A, Member 2/metabolism ; Parkinson Disease, Secondary/chemically induced ; Parkinson Disease, Secondary/drug therapy ; Parkinson Disease, Secondary/genetics ; Parkinson Disease, Secondary/pathology ; Rats ; Rats, Wistar ; Rotenone
Czasopismo naukowe
Tytuł :
Biological implications and limitations of a cynomolgus monkey with naturally occurring Parkinson's disease.
Autorzy :
Li H; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; National Resource Center for Non-Human Primates, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China.
Yao YG; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; National Resource Center for Non-Human Primates, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China.; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China. E-mail: .
Hu XT; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; National Resource Center for Non-Human Primates, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China.; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China. E-mail:.
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Źródło :
Zoological research [Zool Res] 2021 Mar 18; Vol. 42 (2), pp. 138-140.
Typ publikacji :
Editorial
MeSH Terms :
Macaca fascicularis*
Monkey Diseases/*pathology
Parkinson Disease/*veterinary
Animals ; Humans ; Male ; Monkey Diseases/genetics ; Mutation ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Species Specificity
Opinia redakcyjna
Tytuł :
No impact of confinement during COVID-19 pandemic on anxiety and depression in Parkinsonian patients.
Autorzy :
El Otmani H; Neurology Department, Ibn Rochd Hospital, Casablanca, Morocco; Genetics and Molecular Biology Laboratory; Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco. Electronic address: .
El Bidaoui Z; Neurology Department, Ibn Rochd Hospital, Casablanca, Morocco; Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Amzil R; Neurology Department, Ibn Rochd Hospital, Casablanca, Morocco; Genetics and Molecular Biology Laboratory; Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Bellakhdar S; Neurology Department, Ibn Rochd Hospital, Casablanca, Morocco; Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
El Moutawakil B; Neurology Department, Ibn Rochd Hospital, Casablanca, Morocco; Genetics and Molecular Biology Laboratory; Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Abdoh Rafai M; Neurology Department, Ibn Rochd Hospital, Casablanca, Morocco; Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
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Źródło :
Revue neurologique [Rev Neurol (Paris)] 2021 Mar; Vol. 177 (3), pp. 272-274. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Pandemics*
Anxiety/*epidemiology
COVID-19/*epidemiology
Depression/*epidemiology
Parkinson Disease/*epidemiology
Quarantine/*psychology
Aged ; COVID-19/psychology ; Female ; Humans ; Male ; Middle Aged ; Morocco/epidemiology ; Parkinson Disease/complications ; Parkinson Disease/psychology ; SARS-CoV-2/physiology ; Stress, Psychological/epidemiology ; Stress, Psychological/psychology ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł :
Response to: The need of reliable warning signs for dysphagia in Parkinson's disease: an often-overlooked issue.
Autorzy :
Patel B; Department of Neurology, University of Florida College of Medicine , Gainesville, FL, USA.; Norman Fixel Institute for Neurological Diseases , Gainesville, FL, USA.
Legacy J; Department of Neurology, University of Florida College of Medicine , Gainesville, FL, USA.; Norman Fixel Institute for Neurological Diseases , Gainesville, FL, USA.
Okun MS; Department of Neurology, University of Florida College of Medicine , Gainesville, FL, USA.; Norman Fixel Institute for Neurological Diseases , Gainesville, FL, USA.
Wheeler-Hegland K; UF Health Rehab Center at Norman Fixel Institute for Neurological Diseases , Gainesville, FL, USA.; Department of Speech, Language and Hearing Sciences, University of Florida , Gainesville, FL, USA.
Herndon NE; UF Health Rehab Center at Norman Fixel Institute for Neurological Diseases , Gainesville, FL, USA.; Department of Speech, Language and Hearing Sciences, University of Florida , Gainesville, FL, USA.
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Źródło :
Expert review of gastroenterology & hepatology [Expert Rev Gastroenterol Hepatol] 2021 Mar; Vol. 15 (3), pp. 343-344. Date of Electronic Publication: 2021 Jan 03.
Typ publikacji :
Letter; Comment
MeSH Terms :
Deglutition Disorders*/diagnosis
Deglutition Disorders*/epidemiology
Deglutition Disorders*/etiology
Parkinson Disease*/complications
Parkinson Disease*/diagnosis
Parkinson Disease*/epidemiology
Humans
Opinia redakcyjna
Tytuł :
Diagnostic performance of neuromelanin-sensitive magnetic resonance imaging for patients with Parkinson's disease and factor analysis for its heterogeneity: a systematic review and meta-analysis.
Autorzy :
Cho SJ; Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, Gyeonggi, 13620, Republic of Korea.
Bae YJ; Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, Gyeonggi, 13620, Republic of Korea. .
Kim JM; Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, Gyeonggi, 13620, Republic of Korea.
Kim D; Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, 75, Bokji-ro, Busanjin-gu, Busan, 47392, Republic of Korea.
Baik SH; Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, Gyeonggi, 13620, Republic of Korea.
Sunwoo L; Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, Gyeonggi, 13620, Republic of Korea.
Choi BS; Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, Gyeonggi, 13620, Republic of Korea.
Kim JH; Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, Gyeonggi, 13620, Republic of Korea.
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Źródło :
European radiology [Eur Radiol] 2021 Mar; Vol. 31 (3), pp. 1268-1280. Date of Electronic Publication: 2020 Sep 04.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Parkinson Disease*/diagnostic imaging
Factor Analysis, Statistical ; Humans ; Magnetic Resonance Imaging ; Melanins ; Substantia Nigra
Czasopismo naukowe
Tytuł :
Neuroprotective and Anti-Inflammatory Effects of Evernic Acid in an MPTP-Induced Parkinson's Disease Model.
Autorzy :
Lee S; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Suh YJ; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Yang S; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Hong DG; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Ishigami A; Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan.
Kim H; College of Pharmacy, Sunchon National University, Suncheon 57922, Korea.
Hur JS; Korean Lichen Research Institute, Sunchon National University, Suncheon 57922, Korea.
Chang SC; Department of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan 46241, Korea.
Lee J; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 20; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 20.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*therapeutic use
Hydroxybenzoates/*therapeutic use
Neuroprotective Agents/*therapeutic use
Parkinson Disease/*drug therapy
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Anti-Inflammatory Agents/pharmacology ; Apoptosis/drug effects ; Astrocytes/drug effects ; Astrocytes/metabolism ; Astrocytes/pathology ; Cells, Cultured ; Disease Models, Animal ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology ; Drug Evaluation, Preclinical ; Hydroxybenzoates/chemistry ; Hydroxybenzoates/pharmacology ; Lichens/chemistry ; Male ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Mitochondria/metabolism ; Motor Activity/drug effects ; NF-kappa B/metabolism ; Neuroprotective Agents/pharmacology ; Oxidative Stress/drug effects ; Parkinson Disease/pathology ; Parkinson Disease/physiopathology ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Chitosan nanocarrier for FTY720 enhanced delivery retards Parkinson's disease via PP2A-EzH2 signaling in vitro and ex vivo.
Autorzy :
Sardoiwala MN; Institute of Nano Science and Technology, Habitat Centre, Phase-10, Mohali, Punjab, 160062, India.
Karmakar S; Institute of Nano Science and Technology, Habitat Centre, Phase-10, Mohali, Punjab, 160062, India.
Choudhury SR; Institute of Nano Science and Technology, Habitat Centre, Phase-10, Mohali, Punjab, 160062, India. Electronic address: .
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2021 Feb 15; Vol. 254, pp. 117435. Date of Electronic Publication: 2020 Nov 22.
Typ publikacji :
Journal Article
MeSH Terms :
Chitosan/*chemistry
Enhancer of Zeste Homolog 2 Protein/*genetics
Fingolimod Hydrochloride/*pharmacology
Neuroprotective Agents/*pharmacology
Parkinson Disease/*drug therapy
Protein Phosphatase 2/*genetics
Sphingosine 1 Phosphate Receptor Modulators/*pharmacology
Animals ; Biological Availability ; Cell Line, Tumor ; Disease Models, Animal ; Drug Carriers/chemistry ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Epigenesis, Genetic ; Fingolimod Hydrochloride/pharmacokinetics ; Humans ; Mice ; Mice, Inbred BALB C ; Neurons/metabolism ; Neurons/pathology ; Neuroprotective Agents/pharmacokinetics ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Phosphorylation/drug effects ; Protein Aggregates/drug effects ; Protein Phosphatase 2/metabolism ; Proteolysis/drug effects ; Signal Transduction ; Sphingosine 1 Phosphate Receptor Modulators/pharmacokinetics ; Ubiquitination/drug effects ; alpha-Synuclein/chemistry ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism
Czasopismo naukowe
Tytuł :
Association of Hippocampal Subfields, CSF Biomarkers, and Cognition in Patients With Parkinson Disease Without Dementia.
Autorzy :
Becker S; From the Department of Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Hertie Institute for Clinical Brain Research; German Center for Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Tübingen; Department of Neurology (O.G., W.M., D.B.), Christian-Albrechts-University, Kiel, Germany; Janssen Research and Development, a Division of Janssen Pharmaceutica N.V. (M.T., L.V.N., J.S.), Beerse; Reference Center for Biological Markers of Dementia (M.T.), Institute Born-Bunge, University of Antwerp, Belgium; Department of Clinical and Experimental Sciences (A.P.), University of Brescia; Parkinson's Disease Rehabilitation Centre (A.P.), FERB ONLUS Sant'Isidoro Hospital, Trescore Balneario, Italy; Janssen Research and Development LLC (G.S., W.R.G.), Titusville, NJ; Translational Medicine Neuroscience (J.S.), UCB Biopharma SPRK, Braine-l'Alleud, Belgium; Magnetic Resonance Center (K.S.), Max Planck Institute for Biological Cybernetics; and Department of Biomedical Magnetic Resonance (K.S.), University Hospital Tübingen, Germany. .
Granert O; From the Department of Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Hertie Institute for Clinical Brain Research; German Center for Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Tübingen; Department of Neurology (O.G., W.M., D.B.), Christian-Albrechts-University, Kiel, Germany; Janssen Research and Development, a Division of Janssen Pharmaceutica N.V. (M.T., L.V.N., J.S.), Beerse; Reference Center for Biological Markers of Dementia (M.T.), Institute Born-Bunge, University of Antwerp, Belgium; Department of Clinical and Experimental Sciences (A.P.), University of Brescia; Parkinson's Disease Rehabilitation Centre (A.P.), FERB ONLUS Sant'Isidoro Hospital, Trescore Balneario, Italy; Janssen Research and Development LLC (G.S., W.R.G.), Titusville, NJ; Translational Medicine Neuroscience (J.S.), UCB Biopharma SPRK, Braine-l'Alleud, Belgium; Magnetic Resonance Center (K.S.), Max Planck Institute for Biological Cybernetics; and Department of Biomedical Magnetic Resonance (K.S.), University Hospital Tübingen, Germany.
Timmers M; From the Department of Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Hertie Institute for Clinical Brain Research; German Center for Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Tübingen; Department of Neurology (O.G., W.M., D.B.), Christian-Albrechts-University, Kiel, Germany; Janssen Research and Development, a Division of Janssen Pharmaceutica N.V. (M.T., L.V.N., J.S.), Beerse; Reference Center for Biological Markers of Dementia (M.T.), Institute Born-Bunge, University of Antwerp, Belgium; Department of Clinical and Experimental Sciences (A.P.), University of Brescia; Parkinson's Disease Rehabilitation Centre (A.P.), FERB ONLUS Sant'Isidoro Hospital, Trescore Balneario, Italy; Janssen Research and Development LLC (G.S., W.R.G.), Titusville, NJ; Translational Medicine Neuroscience (J.S.), UCB Biopharma SPRK, Braine-l'Alleud, Belgium; Magnetic Resonance Center (K.S.), Max Planck Institute for Biological Cybernetics; and Department of Biomedical Magnetic Resonance (K.S.), University Hospital Tübingen, Germany.
Pilotto A; From the Department of Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Hertie Institute for Clinical Brain Research; German Center for Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Tübingen; Department of Neurology (O.G., W.M., D.B.), Christian-Albrechts-University, Kiel, Germany; Janssen Research and Development, a Division of Janssen Pharmaceutica N.V. (M.T., L.V.N., J.S.), Beerse; Reference Center for Biological Markers of Dementia (M.T.), Institute Born-Bunge, University of Antwerp, Belgium; Department of Clinical and Experimental Sciences (A.P.), University of Brescia; Parkinson's Disease Rehabilitation Centre (A.P.), FERB ONLUS Sant'Isidoro Hospital, Trescore Balneario, Italy; Janssen Research and Development LLC (G.S., W.R.G.), Titusville, NJ; Translational Medicine Neuroscience (J.S.), UCB Biopharma SPRK, Braine-l'Alleud, Belgium; Magnetic Resonance Center (K.S.), Max Planck Institute for Biological Cybernetics; and Department of Biomedical Magnetic Resonance (K.S.), University Hospital Tübingen, Germany.
Van Nueten L; From the Department of Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Hertie Institute for Clinical Brain Research; German Center for Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Tübingen; Department of Neurology (O.G., W.M., D.B.), Christian-Albrechts-University, Kiel, Germany; Janssen Research and Development, a Division of Janssen Pharmaceutica N.V. (M.T., L.V.N., J.S.), Beerse; Reference Center for Biological Markers of Dementia (M.T.), Institute Born-Bunge, University of Antwerp, Belgium; Department of Clinical and Experimental Sciences (A.P.), University of Brescia; Parkinson's Disease Rehabilitation Centre (A.P.), FERB ONLUS Sant'Isidoro Hospital, Trescore Balneario, Italy; Janssen Research and Development LLC (G.S., W.R.G.), Titusville, NJ; Translational Medicine Neuroscience (J.S.), UCB Biopharma SPRK, Braine-l'Alleud, Belgium; Magnetic Resonance Center (K.S.), Max Planck Institute for Biological Cybernetics; and Department of Biomedical Magnetic Resonance (K.S.), University Hospital Tübingen, Germany.
Roeben B; From the Department of Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Hertie Institute for Clinical Brain Research; German Center for Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Tübingen; Department of Neurology (O.G., W.M., D.B.), Christian-Albrechts-University, Kiel, Germany; Janssen Research and Development, a Division of Janssen Pharmaceutica N.V. (M.T., L.V.N., J.S.), Beerse; Reference Center for Biological Markers of Dementia (M.T.), Institute Born-Bunge, University of Antwerp, Belgium; Department of Clinical and Experimental Sciences (A.P.), University of Brescia; Parkinson's Disease Rehabilitation Centre (A.P.), FERB ONLUS Sant'Isidoro Hospital, Trescore Balneario, Italy; Janssen Research and Development LLC (G.S., W.R.G.), Titusville, NJ; Translational Medicine Neuroscience (J.S.), UCB Biopharma SPRK, Braine-l'Alleud, Belgium; Magnetic Resonance Center (K.S.), Max Planck Institute for Biological Cybernetics; and Department of Biomedical Magnetic Resonance (K.S.), University Hospital Tübingen, Germany.
Salvadore G; From the Department of Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Hertie Institute for Clinical Brain Research; German Center for Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Tübingen; Department of Neurology (O.G., W.M., D.B.), Christian-Albrechts-University, Kiel, Germany; Janssen Research and Development, a Division of Janssen Pharmaceutica N.V. (M.T., L.V.N., J.S.), Beerse; Reference Center for Biological Markers of Dementia (M.T.), Institute Born-Bunge, University of Antwerp, Belgium; Department of Clinical and Experimental Sciences (A.P.), University of Brescia; Parkinson's Disease Rehabilitation Centre (A.P.), FERB ONLUS Sant'Isidoro Hospital, Trescore Balneario, Italy; Janssen Research and Development LLC (G.S., W.R.G.), Titusville, NJ; Translational Medicine Neuroscience (J.S.), UCB Biopharma SPRK, Braine-l'Alleud, Belgium; Magnetic Resonance Center (K.S.), Max Planck Institute for Biological Cybernetics; and Department of Biomedical Magnetic Resonance (K.S.), University Hospital Tübingen, Germany.
Galpern WR; From the Department of Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Hertie Institute for Clinical Brain Research; German Center for Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Tübingen; Department of Neurology (O.G., W.M., D.B.), Christian-Albrechts-University, Kiel, Germany; Janssen Research and Development, a Division of Janssen Pharmaceutica N.V. (M.T., L.V.N., J.S.), Beerse; Reference Center for Biological Markers of Dementia (M.T.), Institute Born-Bunge, University of Antwerp, Belgium; Department of Clinical and Experimental Sciences (A.P.), University of Brescia; Parkinson's Disease Rehabilitation Centre (A.P.), FERB ONLUS Sant'Isidoro Hospital, Trescore Balneario, Italy; Janssen Research and Development LLC (G.S., W.R.G.), Titusville, NJ; Translational Medicine Neuroscience (J.S.), UCB Biopharma SPRK, Braine-l'Alleud, Belgium; Magnetic Resonance Center (K.S.), Max Planck Institute for Biological Cybernetics; and Department of Biomedical Magnetic Resonance (K.S.), University Hospital Tübingen, Germany.
Streffer J; From the Department of Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Hertie Institute for Clinical Brain Research; German Center for Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Tübingen; Department of Neurology (O.G., W.M., D.B.), Christian-Albrechts-University, Kiel, Germany; Janssen Research and Development, a Division of Janssen Pharmaceutica N.V. (M.T., L.V.N., J.S.), Beerse; Reference Center for Biological Markers of Dementia (M.T.), Institute Born-Bunge, University of Antwerp, Belgium; Department of Clinical and Experimental Sciences (A.P.), University of Brescia; Parkinson's Disease Rehabilitation Centre (A.P.), FERB ONLUS Sant'Isidoro Hospital, Trescore Balneario, Italy; Janssen Research and Development LLC (G.S., W.R.G.), Titusville, NJ; Translational Medicine Neuroscience (J.S.), UCB Biopharma SPRK, Braine-l'Alleud, Belgium; Magnetic Resonance Center (K.S.), Max Planck Institute for Biological Cybernetics; and Department of Biomedical Magnetic Resonance (K.S.), University Hospital Tübingen, Germany.
Scheffler K; From the Department of Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Hertie Institute for Clinical Brain Research; German Center for Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Tübingen; Department of Neurology (O.G., W.M., D.B.), Christian-Albrechts-University, Kiel, Germany; Janssen Research and Development, a Division of Janssen Pharmaceutica N.V. (M.T., L.V.N., J.S.), Beerse; Reference Center for Biological Markers of Dementia (M.T.), Institute Born-Bunge, University of Antwerp, Belgium; Department of Clinical and Experimental Sciences (A.P.), University of Brescia; Parkinson's Disease Rehabilitation Centre (A.P.), FERB ONLUS Sant'Isidoro Hospital, Trescore Balneario, Italy; Janssen Research and Development LLC (G.S., W.R.G.), Titusville, NJ; Translational Medicine Neuroscience (J.S.), UCB Biopharma SPRK, Braine-l'Alleud, Belgium; Magnetic Resonance Center (K.S.), Max Planck Institute for Biological Cybernetics; and Department of Biomedical Magnetic Resonance (K.S.), University Hospital Tübingen, Germany.
Maetzler W; From the Department of Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Hertie Institute for Clinical Brain Research; German Center for Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Tübingen; Department of Neurology (O.G., W.M., D.B.), Christian-Albrechts-University, Kiel, Germany; Janssen Research and Development, a Division of Janssen Pharmaceutica N.V. (M.T., L.V.N., J.S.), Beerse; Reference Center for Biological Markers of Dementia (M.T.), Institute Born-Bunge, University of Antwerp, Belgium; Department of Clinical and Experimental Sciences (A.P.), University of Brescia; Parkinson's Disease Rehabilitation Centre (A.P.), FERB ONLUS Sant'Isidoro Hospital, Trescore Balneario, Italy; Janssen Research and Development LLC (G.S., W.R.G.), Titusville, NJ; Translational Medicine Neuroscience (J.S.), UCB Biopharma SPRK, Braine-l'Alleud, Belgium; Magnetic Resonance Center (K.S.), Max Planck Institute for Biological Cybernetics; and Department of Biomedical Magnetic Resonance (K.S.), University Hospital Tübingen, Germany.
Berg D; From the Department of Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Hertie Institute for Clinical Brain Research; German Center for Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Tübingen; Department of Neurology (O.G., W.M., D.B.), Christian-Albrechts-University, Kiel, Germany; Janssen Research and Development, a Division of Janssen Pharmaceutica N.V. (M.T., L.V.N., J.S.), Beerse; Reference Center for Biological Markers of Dementia (M.T.), Institute Born-Bunge, University of Antwerp, Belgium; Department of Clinical and Experimental Sciences (A.P.), University of Brescia; Parkinson's Disease Rehabilitation Centre (A.P.), FERB ONLUS Sant'Isidoro Hospital, Trescore Balneario, Italy; Janssen Research and Development LLC (G.S., W.R.G.), Titusville, NJ; Translational Medicine Neuroscience (J.S.), UCB Biopharma SPRK, Braine-l'Alleud, Belgium; Magnetic Resonance Center (K.S.), Max Planck Institute for Biological Cybernetics; and Department of Biomedical Magnetic Resonance (K.S.), University Hospital Tübingen, Germany.
Liepelt-Scarfone I; From the Department of Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Hertie Institute for Clinical Brain Research; German Center for Neurodegenerative Diseases (S.B., B.R., I.L.-S.), Tübingen; Department of Neurology (O.G., W.M., D.B.), Christian-Albrechts-University, Kiel, Germany; Janssen Research and Development, a Division of Janssen Pharmaceutica N.V. (M.T., L.V.N., J.S.), Beerse; Reference Center for Biological Markers of Dementia (M.T.), Institute Born-Bunge, University of Antwerp, Belgium; Department of Clinical and Experimental Sciences (A.P.), University of Brescia; Parkinson's Disease Rehabilitation Centre (A.P.), FERB ONLUS Sant'Isidoro Hospital, Trescore Balneario, Italy; Janssen Research and Development LLC (G.S., W.R.G.), Titusville, NJ; Translational Medicine Neuroscience (J.S.), UCB Biopharma SPRK, Braine-l'Alleud, Belgium; Magnetic Resonance Center (K.S.), Max Planck Institute for Biological Cybernetics; and Department of Biomedical Magnetic Resonance (K.S.), University Hospital Tübingen, Germany.
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Źródło :
Neurology [Neurology] 2021 Feb 09; Vol. 96 (6), pp. e904-e915. Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*cerebrospinal fluid
Cognitive Dysfunction/*physiopathology
Hippocampus/*pathology
Parkinson Disease/*cerebrospinal fluid
Parkinson Disease/*pathology
Parkinson Disease/*physiopathology
Peptide Fragments/*cerebrospinal fluid
tau Proteins/*cerebrospinal fluid
Activities of Daily Living ; Aged ; Biomarkers/cerebrospinal fluid ; CA1 Region, Hippocampal/diagnostic imaging ; CA1 Region, Hippocampal/pathology ; Cognitive Dysfunction/etiology ; Female ; Follow-Up Studies ; Hippocampus/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuropsychological Tests ; Parkinson Disease/complications
Czasopismo naukowe
Tytuł :
Effect of robot-assisted gait training on gait automaticity in Parkinson disease: A prospective, open-label, single-arm, pilot study.
Autorzy :
Yun SJ; Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital.
Lee HH; Department of Rehabilitation Medicine, Konkuk University Medical Center.
Lee WH; Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital.
Lee SH; Department of Rehabilitation Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of Korea.
Oh BM; Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital.
Seo HG; Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Feb 05; Vol. 100 (5), pp. e24348.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Exoskeleton Device*
Exercise Therapy/*instrumentation
Gait Disorders, Neurologic/*therapy
Parkinson Disease/*therapy
Robotics/*instrumentation
Aged ; Exercise Therapy/methods ; Female ; Gait/physiology ; Gait Analysis ; Gait Disorders, Neurologic/etiology ; Gait Disorders, Neurologic/physiopathology ; Humans ; Male ; Middle Aged ; Parkinson Disease/complications ; Parkinson Disease/physiopathology ; Pilot Projects ; Prospective Studies ; Republic of Korea ; Robotics/methods ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Tools to assess the quality of life in patients with Parkinson's disease: a systematic review.
Autorzy :
Berardi A; Department of Human Neurosciences, Sapienza University of Rome , Rome, Italy.
Regoli E; Sapienza University of Rome , Rome, Italy.
Tofani M; Department of Neurorehabilitation and Robotics, Bambino Gesù Paediatric Hospital , Rome, Italy.
Valente D; Department of Human Neurosciences, Sapienza University of Rome , Rome, Italy.; IRCCS Neuromed , Pozzilli, Italy.
Fabbrini G; Department of Human Neurosciences, Sapienza University of Rome , Rome, Italy.; IRCCS Neuromed , Pozzilli, Italy.
Fabbrini A; IRCCS Neuromed , Pozzilli, Italy.
Ruggieri M; Santa Lucia Foundation IRCCS , Rome, Italy.
Panuccio F; Sapienza University of Rome , Rome, Italy.
Galeoto G; Department of Human Neurosciences, Sapienza University of Rome , Rome, Italy.
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Źródło :
Expert review of pharmacoeconomics & outcomes research [Expert Rev Pharmacoecon Outcomes Res] 2021 Feb; Vol. 21 (1), pp. 55-68. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Quality of Life*
Outcome Assessment, Health Care/*methods
Parkinson Disease/*physiopathology
Cognition ; Decision Making ; Disability Evaluation ; Humans ; Parkinson Disease/psychology ; Parkinson Disease/therapy ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł :
[18F]PR04.MZ PET/CT Imaging for Evaluation of Nigrostriatal Neuron Integrity in Patients With Parkinson Disease.
Autorzy :
Juri C
Kramer V
Riss PJ; Department of Chemistry, University of Oslo, Oslo, Norway.
Soza-Ried C; Positronpharma SA, Santiago, Chile.
Haeger A; Positronpharma SA, Santiago, Chile.
Pruzzo R; Positronpharma SA, Santiago, Chile.
Rösch F; Institute of Nuclear Chemistry, Johannes Gutenberg-University, Mainz, Germany.
Amaral H
Chana-Cuevas P
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Źródło :
Clinical nuclear medicine [Clin Nucl Med] 2021 Feb 01; Vol. 46 (2), pp. 119-124.
Typ publikacji :
Journal Article
MeSH Terms :
Positron Emission Tomography Computed Tomography*
Neurons/*pathology
Parkinson Disease/*diagnostic imaging
Parkinson Disease/*pathology
Substantia Nigra/*pathology
Aged ; Cohort Studies ; Dopamine/metabolism ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Female ; Humans ; Male ; Middle Aged ; Neurons/metabolism ; Parkinson Disease/metabolism
Czasopismo naukowe
Tytuł :
Effectiveness of Levodopa in Patients with Multiple System Atrophy and Associated Clinicopathological Features.
Autorzy :
Ishida C; Department of Neurology, National Hospital Organization Iou National Hospital, Hokuriku Brain and Neuromuscular Disease Center, Japan.
Takahashi K; Department of Neurology, National Hospital Organization Iou National Hospital, Hokuriku Brain and Neuromuscular Disease Center, Japan.
Kato-Motozaki Y; Department of Neurology, National Hospital Organization Iou National Hospital, Hokuriku Brain and Neuromuscular Disease Center, Japan.
Tagami A; Department of Respiratory Medicine, National Hospital Organization Iou National Hospital, Hokuriku Brain and Neuromuscular Disease Center, Japan.
Komai K; Department of Neurology, National Hospital Organization Iou National Hospital, Hokuriku Brain and Neuromuscular Disease Center, Japan.
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Źródło :
Internal medicine (Tokyo, Japan) [Intern Med] 2021 Feb 01; Vol. 60 (3), pp. 367-372. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Multiple System Atrophy*/diagnostic imaging
Multiple System Atrophy*/drug therapy
Parkinson Disease*/diagnosis
Parkinson Disease*/drug therapy
Supranuclear Palsy, Progressive*/diagnostic imaging
Supranuclear Palsy, Progressive*/drug therapy
Diagnosis, Differential ; Humans ; Levodopa/therapeutic use ; Magnetic Resonance Imaging ; Putamen
Czasopismo naukowe
Tytuł :
Desflurane and sevoflurane differentially affect activity of the subthalamic nucleus in Parkinson's disease.
Autorzy :
Chen YC; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation/Tzu Chi University, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
Chen SY; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation/Tzu Chi University, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
Chen TY; Department of Anaesthesiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation/Tzu Chi University, Hualien, Taiwan.
Pan JI; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan; Department of Medical Informatics, Tzu Chi University, Hualien, Taiwan.
Tsai ST; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation/Tzu Chi University, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address: .
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Źródło :
British journal of anaesthesia [Br J Anaesth] 2021 Feb; Vol. 126 (2), pp. 477-485. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anesthetics, Inhalation/*administration & dosage
Brain Waves/*drug effects
Desflurane/*administration & dosage
Parkinson Disease/*therapy
Sevoflurane/*administration & dosage
Subthalamic Nucleus/*drug effects
Adult ; Aged ; Deep Brain Stimulation ; Electroencephalography ; Female ; Humans ; Intraoperative Neurophysiological Monitoring ; Male ; Middle Aged ; Parkinson Disease/diagnosis ; Parkinson Disease/physiopathology ; Subthalamic Nucleus/physiopathology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Huang Lian Jie Du Tang attenuates paraquat-induced mitophagy in human SH-SY5Y cells: A traditional decoction with a novel therapeutic potential in treating Parkinson's disease.
Autorzy :
Lee IJ; Herbal Medicine Department, Yokohama University of Pharmacy, Yokohama, Japan.
Chao CY; Department of Psychiatry, Cardinal Tien Hospital, New Taipei City 23148, Taiwan, ROC.
Yang YC; Department of Biotechnology and Animal Science, National Ilan University, Ilan 26047, Taiwan, ROC.
Cheng JJ; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11267, Taiwan, ROC.
Huang CL; Medical Research Center, Cardinal Tien Hospital, Hsintien, New Taipei City 23148, Taiwan, ROC; Graduate Institute of Physiology & Department of Physiology and Biophysics, National Defense Medical Center, Taipei 11490, Taiwan, ROC.
Chiou CT; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11267, Taiwan, ROC.
Huang HT; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11267, Taiwan, ROC.
Kuo YH; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11267, Taiwan, ROC; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan, ROC.
Huang NK; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11267, Taiwan, ROC; The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan, ROC; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 11031, Taiwan, ROC. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Feb; Vol. 134, pp. 111170. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article
MeSH Terms :
Antiparkinson Agents/*pharmacology
Drugs, Chinese Herbal/*pharmacology
Mitochondria/*drug effects
Mitophagy/*drug effects
Neurons/*drug effects
Paraquat/*toxicity
Parkinson Disease/*drug therapy
Apoptosis/drug effects ; Cell Line, Tumor ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Neurons/metabolism ; Neurons/pathology ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Phosphorylation ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Revisiting dopamine-acetylcholine imbalance in Parkinson's disease: Glutamate co-transmission as an exciting partner in crime.
Autorzy :
Zhang YF; Department of Physiology, Anatomy and Genetics, and Oxford Parkinson's Disease Centre, University of Oxford, Oxford OX1 3PT, UK.
Cragg SJ; Department of Physiology, Anatomy and Genetics, and Oxford Parkinson's Disease Centre, University of Oxford, Oxford OX1 3PT, UK. Electronic address: .
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Źródło :
Neuron [Neuron] 2021 Apr 07; Vol. 109 (7), pp. 1070-1071.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Motor Disorders*
Parkinson Disease*
Acetylcholine ; Animals ; Cholinergic Agents ; Corpus Striatum ; Crime ; Dopamine ; Glutamic Acid ; Interneurons ; Mice
Czasopismo naukowe
Tytuł :
How dopamine leads to hallucinations.
Autorzy :
Matamales M; Decision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, Australia. .
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Źródło :
Science (New York, N.Y.) [Science] 2021 Apr 02; Vol. 372 (6537), pp. 33-34.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Dopamine*
Parkinson Disease*/drug therapy
Hallucinations/chemically induced ; Humans
Czasopismo naukowe

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