Temat: "Parkinson disease" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Alterations in cortical volume and complexity in Parkinson's disease with depression.
Autorzy:: Yuan J; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Liu Y; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Liao H; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.; Clinical Research Center For Medical Imaging in Hunan Province, Changsha, China.
Tan C; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Cai S; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Shen Q; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Liu Q; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Wang M; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Tang Y; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Li X; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Liu J; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.; Clinical Research Center For Medical Imaging in Hunan Province, Changsha, China.
Zi Y; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.; Department of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.; Pokaż więcej
Źródło:: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14582.
Typ publikacji:: Journal Article
MeSH Terms:: Brain*
Parkinson Disease*/diagnostic imaging
Humans ; Depression/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Gray Matter/diagnostic imaging

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Skocz do pozycji: 2.

Tytuł:: Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases.
Autorzy:: Butterfield DA; Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA.
Favia M; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70125 Bari, Italy.
Spera I; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70125 Bari, Italy.
Campanella A; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70125 Bari, Italy.
Lanza M; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70125 Bari, Italy.
Castegna A; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70125 Bari, Italy.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Jan 30; Vol. 27 (3). Date of Electronic Publication: 2022 Jan 30.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Nervous System Physiological Phenomena*
Alzheimer Disease/*pathology
Brain/*metabolism
Metabolic Diseases/*complications
Parkinson Disease/*pathology
Alzheimer Disease/etiology ; Alzheimer Disease/metabolism ; Animals ; Brain/pathology ; Humans ; Metabolic Diseases/metabolism ; Parkinson Disease/etiology ; Parkinson Disease/metabolism

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Skocz do pozycji: 3.

Tytuł:: Identification of an early-stage Parkinson's disease neuromarker using event-related potentials, brain network analytics and machine-learning.
Autorzy:: Hassin-Baer S; Movement Disorders Institute and Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel.; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Cohen OS; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Department of Neurology, Assaf Harofeh Medical Center, Zerifin, Israel.
Israeli-Korn S; Movement Disorders Institute and Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel.; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Yahalom G; Department of Neurology and Movement Disorders Clinic, Shaare Zedek Medical Center, Jerusalem, Israel.
Benizri S; Movement Disorders Unit, Functional Neurosurgery Center, Assuta Ramat Ha Hayal Hospital, Tel Aviv, Israel.
Sand D; elminda Ltd., Herzliya, Israel.; Faculty of Medicine, Department of Medical Neurobiology, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel.
Issachar G; elminda Ltd., Herzliya, Israel.
Geva AB; elminda Ltd., Herzliya, Israel.; Department of Electrical and Computer Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Shani-Hershkovich R; elminda Ltd., Herzliya, Israel.
Peremen Z; elminda Ltd., Herzliya, Israel.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2022 Jan 07; Vol. 17 (1), pp. e0261947. Date of Electronic Publication: 2022 Jan 07 (Print Publication: 2022).
Typ publikacji:: Clinical Trial; Journal Article; Multicenter Study
MeSH Terms:: Electroencephalography*
Evoked Potentials*
Machine Learning*
Parkinson Disease*/diagnosis
Parkinson Disease*/physiopathology
Brain/*physiopathology
Aged ; Female ; Humans ; Male ; Middle Aged

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Skocz do pozycji: 4.

Tytuł:: Brain Neuroimaging of Rapid Eye Movement Sleep Behavior Disorder in Parkinson's Disease: A Systematic Review.
Autorzy:: Matzaras R; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
Shi K; Department of Nuclear Medicine, University of Bern, Switzerland.
Artemiadis A; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
Zis P; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
Hadjigeorgiou G; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
Rominger A; Department of Nuclear Medicine, University of Bern, Switzerland.
Bassetti CLA; Department of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.
Bargiotas P; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.; Pokaż więcej
Źródło:: Journal of Parkinson's disease [J Parkinsons Dis] 2022; Vol. 12 (1), pp. 69-83.
Typ publikacji:: Journal Article; Systematic Review
MeSH Terms:: Brain*/diagnostic imaging
Parkinson Disease*/complications
Parkinson Disease*/diagnostic imaging
REM Sleep Behavior Disorder*/complications
REM Sleep Behavior Disorder*/diagnostic imaging
Humans ; Magnetic Resonance Imaging ; Neuroimaging

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Skocz do pozycji: 5.

Tytuł:: Digging Deeper: Advancements in Visualization of Inhibitory Synapses in Neurodegenerative Disorders.
Autorzy:: Radulović S; Gottfried Schatz Research Center, Division of Cell Biology, Histology and Embryology, Medical University of Graz, 8010 Graz, Austria.
Sunkara S; Gottfried Schatz Research Center, Division of Cell Biology, Histology and Embryology, Medical University of Graz, 8010 Graz, Austria.
Maurer C; Gottfried Schatz Research Center, Division of Macroscopic and Clinical Anatomy, Medical University of Graz, 8010 Graz, Austria.
Leitinger G; Gottfried Schatz Research Center, Division of Cell Biology, Histology and Embryology, Medical University of Graz, 8010 Graz, Austria.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 18; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 18.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Alzheimer Disease/*diagnostic imaging
Brain/*diagnostic imaging
Neurons/*ultrastructure
Neuroprotective Agents/*therapeutic use
Parkinson Disease/*diagnostic imaging
Synapses/*ultrastructure
Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyotrophic Lateral Sclerosis/diagnostic imaging ; Amyotrophic Lateral Sclerosis/drug therapy ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Humans ; Huntington Disease/diagnostic imaging ; Huntington Disease/drug therapy ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Levodopa/therapeutic use ; Memantine/therapeutic use ; Microscopy, Electron/methods ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/metabolism ; Multiple Sclerosis/pathology ; Neuronal Plasticity/drug effects ; Neurons/drug effects ; Neurons/metabolism ; Neurotransmitter Agents/metabolism ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Synapses/drug effects ; Synapses/metabolism ; Synaptic Transmission/drug effects ; Tetrabenazine/therapeutic use

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Skocz do pozycji: 6.

Tytuł:: Mercury is present in neurons and oligodendrocytes in regions of the brain affected by Parkinson's disease and co-localises with Lewy bodies.
Autorzy:: Pamphlett R; Sydney Medical School, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.; Department of Neuropathology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Bishop DP; Elemental Bio-Imaging Facility, School of Mathematical and Physical Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2022 Jan 11; Vol. 17 (1), pp. e0262464. Date of Electronic Publication: 2022 Jan 11 (Print Publication: 2022).
Typ publikacji:: Journal Article
MeSH Terms:: Brain/*pathology
Lewy Bodies/*pathology
Locus Coeruleus/*pathology
Mercury/*metabolism
Neurons/*pathology
Oligodendroglia/*pathology
Parkinson Disease/*pathology
Aged ; Aged, 80 and over ; Brain/metabolism ; Case-Control Studies ; Female ; Humans ; Lewy Bodies/metabolism ; Locus Coeruleus/metabolism ; Male ; Mercury/analysis ; Middle Aged ; Neurons/metabolism ; Oligodendroglia/metabolism ; Parkinson Disease/metabolism ; Prognosis ; Retrospective Studies

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Skocz do pozycji: 7.

Tytuł:: Data-driven identification of diagnostically useful extrastriatal signal in dopamine transporter SPECT using explainable AI.
Autorzy:: Nazari M; Department of Computer Science, Biotech, Technical University Dresden, Dresden, Germany.; ABX-CRO Advanced Pharmaceutical Services Forschungsgesellschaft M.B.H., 01307, Dresden, Germany.
Kluge A; ABX-CRO Advanced Pharmaceutical Services Forschungsgesellschaft M.B.H., 01307, Dresden, Germany.
Apostolova I; Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Klutmann S; Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Kimiaei S; ABX-CRO Advanced Pharmaceutical Services Forschungsgesellschaft M.B.H., 01307, Dresden, Germany.
Schroeder M; Department of Computer Science, Biotech, Technical University Dresden, Dresden, Germany.
Buchert R; Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Nov 25; Vol. 11 (1), pp. 22932. Date of Electronic Publication: 2021 Nov 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Image Interpretation, Computer-Assisted*
Neural Networks, Computer*
Tomography, Emission-Computed, Single-Photon*
Brain/*diagnostic imaging
Dopamine Plasma Membrane Transport Proteins/*metabolism
Parkinson Disease/*diagnostic imaging
Radiopharmaceuticals/*administration & dosage
Tropanes/*administration & dosage
Brain/metabolism ; Diagnosis, Differential ; Humans ; Nerve Degeneration ; Parkinson Disease/metabolism ; Predictive Value of Tests ; Radiopharmaceuticals/metabolism ; Reproducibility of Results ; Retrospective Studies ; Tropanes/metabolism

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Skocz do pozycji: 8.

Tytuł:: An autopsy case of pure nigropathy with TUBA4A nonsense mutation.
Autorzy:: Okada K; University of Toyama School of Medicine, Toyama, Japan.; Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.
Hata Y; Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.
Ichimata S; Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.
Yoshida K; Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.
Oku Y; Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.
Asahi T; Department of Neurosurgery, Kanazawa Neurosurgical Hospital, Ishikawa, Japan.
Nishida N; Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.; Pokaż więcej
Źródło:: Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2021 Oct; Vol. 47 (6), pp. 891-893. Date of Electronic Publication: 2021 Apr 05.
Typ publikacji:: Letter
MeSH Terms:: Brain/*pathology
Mutation/*genetics
Parkinson Disease/*genetics
Tubulin/*genetics
Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/genetics ; Autopsy/methods ; Codon, Nonsense/genetics ; Frontotemporal Dementia/diagnosis ; Frontotemporal Dementia/genetics ; Humans ; Parkinson Disease/diagnosis ; Parkinson Disease/pathology
SCR Disease Name:: Frontotemporal Dementia With Motor Neuron Disease

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Skocz do pozycji: 9.

Tytuł:: The intracellular milieu of Parkinson's disease patient brain cells modulates alpha-synuclein protein aggregation.
Autorzy:: Gustavsson N; Medical Microspectroscopy, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Savchenko E; Stem Cell Laboratory for CNS Disease Modelling, Department of Experimental Medical Science, BMC D10, Lund University, Lund, Sweden.
Klementieva O; Medical Microspectroscopy, Department of Experimental Medical Science, Lund University, Lund, Sweden. .
Roybon L; Stem Cell Laboratory for CNS Disease Modelling, Department of Experimental Medical Science, BMC D10, Lund University, Lund, Sweden. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Sep 16; Vol. 9 (1), pp. 153. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain/*metabolism
Intracellular Fluid/*metabolism
Neurons/*metabolism
Parkinson Disease/*metabolism
Protein Aggregates/*physiology
alpha-Synuclein/*metabolism
Brain/pathology ; Female ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Male ; Neurons/pathology ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Spectroscopy, Fourier Transform Infrared/methods ; alpha-Synuclein/genetics

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Skocz do pozycji: 10.

Tytuł:: Novel Pharmacotherapies in Parkinson's Disease.
Autorzy:: Tizabi Y; Department of Pharmacology, Howard University College of Medicine, Washington, DC, 20059, USA. .
Getachew B; Department of Pharmacology, Howard University College of Medicine, Washington, DC, 20059, USA.
Aschner M; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Pokaż więcej
Źródło:: Neurotoxicity research [Neurotox Res] 2021 Aug; Vol. 39 (4), pp. 1381-1390. Date of Electronic Publication: 2021 May 18.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Antiparkinson Agents/*administration & dosage
Brain/*drug effects
Dopamine Agents/*administration & dosage
Dopaminergic Neurons/*drug effects
Parkinson Disease/*drug therapy
Animals ; Brain/metabolism ; Brain/pathology ; Butyrates/administration & dosage ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology ; Drug Therapy, Combination ; Humans ; Levodopa/administration & dosage ; Nicotine/administration & dosage ; Parkinson Disease/metabolism ; Parkinson Disease/pathology

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Skocz do pozycji: 11.

Tytuł:: Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.
Autorzy:: Houser MC; Department of Physiology, Emory University School of Medicine, Atlanta, GA, USA.; Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
Caudle WM; Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Chang J; Department of Physiology, Emory University School of Medicine, Atlanta, GA, USA.
Kannarkat GT; Department of Physiology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA.
Yang Y; Department of Physiology, Emory University School of Medicine, Atlanta, GA, USA.
Kelly SD; Department of Physiology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Oliver D; Department of Physiology, Emory University School of Medicine, Atlanta, GA, USA.
Joers V; Department of Physiology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Shannon KM; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Keshavarzian A; Department of Internal Medicine, Rush Medical College, Chicago, IL, USA.
Tansey MG; Department of Physiology, Emory University School of Medicine, Atlanta, GA, USA. .; Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, 32610, USA. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Aug 19; Vol. 9 (1), pp. 139. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Brain/*metabolism
CD8-Positive T-Lymphocytes/*immunology
Colitis/*immunology
Neuroinflammatory Diseases/*immunology
Parkinson Disease/*immunology
Parkinsonian Disorders/*immunology
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Brain/pathology ; CD8 Antigens/metabolism ; Colitis/chemically induced ; Colitis/genetics ; Colitis/metabolism ; Colon/metabolism ; Dextran Sulfate ; Dopamine/metabolism ; Dopamine Agents ; Female ; Humans ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/metabolism ; Interferon-gamma/metabolism ; Male ; Mice ; Mice, Knockout ; Neuroinflammatory Diseases/genetics ; Neuroinflammatory Diseases/metabolism ; Parkinson Disease/metabolism ; Parkinsonian Disorders/chemically induced ; Parkinsonian Disorders/genetics ; Parkinsonian Disorders/metabolism ; RGS Proteins/genetics ; RGS Proteins/metabolism ; Sex Factors ; Transcription Factor RelA/metabolism ; Tyrosine 3-Monooxygenase/metabolism

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Skocz do pozycji: 12.

Tytuł:: Increased Beta-Hydroxybutyrate Level Is Not Sufficient for the Neuroprotective Effect of Long-Term Ketogenic Diet in an Animal Model of Early Parkinson's Disease. Exploration of Brain and Liver Energy Metabolism Markers.
Autorzy:: Kuter KZ; Deptartment of Neuropsychopharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna 12 St., 31-343 Krakow, Poland.
Olech Ł; Deptartment of Neuropsychopharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna 12 St., 31-343 Krakow, Poland.
Głowacka U; Deptartment of Neuropsychopharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna 12 St., 31-343 Krakow, Poland.
Paleczna M; Deptartment of Neuropsychopharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna 12 St., 31-343 Krakow, Poland.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jul 14; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 14.
Typ publikacji:: Journal Article
MeSH Terms:: 3-Hydroxybutyric Acid/*pharmacology
Brain/*pathology
Diet, Ketogenic/*adverse effects
Dopaminergic Neurons/*pathology
Liver/*pathology
Neuroprotective Agents/*pharmacology
Parkinson Disease/*pathology
Animals ; Brain/drug effects ; Brain/metabolism ; Disease Models, Animal ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Liver/drug effects ; Liver/metabolism ; Male ; Parkinson Disease/etiology ; Parkinson Disease/metabolism ; Rats ; Rats, Wistar

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Skocz do pozycji: 13.

Tytuł:: Pharmacological validation of TDO as a target for Parkinson's disease.
Autorzy:: Perez-Pardo P; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Grobben Y; Netherlands Translational Research Center B.V, Oss, The Netherlands.
Willemsen-Seegers N; Netherlands Translational Research Center B.V, Oss, The Netherlands.
Hartog M; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Tutone M; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Muller M; Netherlands Translational Research Center B.V, Oss, The Netherlands.
Adolfs Y; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Pasterkamp RJ; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Vu-Pham D; Netherlands Translational Research Center B.V, Oss, The Netherlands.
van Doornmalen AM; Netherlands Translational Research Center B.V, Oss, The Netherlands.
van Cauter F; Netherlands Translational Research Center B.V, Oss, The Netherlands.
de Wit J; Netherlands Translational Research Center B.V, Oss, The Netherlands.
Gerard Sterrenburg J; Netherlands Translational Research Center B.V, Oss, The Netherlands.
Uitdehaag JCM; Netherlands Translational Research Center B.V, Oss, The Netherlands.
de Man J; Netherlands Translational Research Center B.V, Oss, The Netherlands.
Buijsman RC; Netherlands Translational Research Center B.V, Oss, The Netherlands.
Zaman GJR; Netherlands Translational Research Center B.V, Oss, The Netherlands.
Kraneveld AD; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.; Pokaż więcej
Źródło:: The FEBS journal [FEBS J] 2021 Jul; Vol. 288 (14), pp. 4311-4331. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Disease Models, Animal*
Brain/*drug effects
Enzyme Inhibitors/*pharmacology
Parkinson Disease/*drug therapy
Rotenone/*toxicity
Small Molecule Libraries/*pharmacology
Tryptophan Oxygenase/*antagonists & inhibitors
Animals ; Brain/pathology ; Cognition/drug effects ; Insecticides/toxicity ; Male ; Mice ; Mice, Inbred C57BL ; Motor Activity/drug effects ; Parkinson Disease/etiology ; Parkinson Disease/pathology

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Skocz do pozycji: 14.

Tytuł:: α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response.
Autorzy:: Delaidelli A; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, V6T 2B5, Canada.; British Columbia Cancer Research Centre, Vancouver, BC, V5Z 1L3, Canada.
Richner M; Danish Research Institute of Translational Neuroscience (DANDRITE)- Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Ole Worms Allé 3, 8000, Aarhus C, Denmark.
Jiang L; Danish Research Institute of Translational Neuroscience (DANDRITE)- Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Ole Worms Allé 3, 8000, Aarhus C, Denmark.
van der Laan A; Danish Research Institute of Translational Neuroscience (DANDRITE)- Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Ole Worms Allé 3, 8000, Aarhus C, Denmark.
Bergholdt Jul Christiansen I; Danish Research Institute of Translational Neuroscience (DANDRITE)- Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Ole Worms Allé 3, 8000, Aarhus C, Denmark.
Ferreira N; Danish Research Institute of Translational Neuroscience (DANDRITE)- Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Ole Worms Allé 3, 8000, Aarhus C, Denmark.
Nyengaard JR; Core Center for Molecular Morphology, Section for Stereology and Microscopy Department of Clinical Medicine, Aarhus University Hospital, 8200, Aarhus N, Denmark.
Vægter CB; Danish Research Institute of Translational Neuroscience (DANDRITE)- Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Ole Worms Allé 3, 8000, Aarhus C, Denmark.
Jensen PH; Danish Research Institute of Translational Neuroscience (DANDRITE)- Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Ole Worms Allé 3, 8000, Aarhus C, Denmark.
Mackenzie IR; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, V6T 2B5, Canada.
Sorensen PH; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, V6T 2B5, Canada.; British Columbia Cancer Research Centre, Vancouver, BC, V5Z 1L3, Canada.
Jan A; Danish Research Institute of Translational Neuroscience (DANDRITE)- Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Ole Worms Allé 3, 8000, Aarhus C, Denmark. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Jun 06; Vol. 9 (1), pp. 105. Date of Electronic Publication: 2021 Jun 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain/*pathology
NF-E2-Related Factor 2/*metabolism
Parkinson Disease/*pathology
alpha-Synuclein/*metabolism
Animals ; Brain/metabolism ; Homeostasis/immunology ; Humans ; Mice ; Mice, Transgenic ; Neuroinflammatory Diseases/etiology ; Neuroinflammatory Diseases/metabolism ; Neuroinflammatory Diseases/pathology ; Oxidation-Reduction ; Parkinson Disease/metabolism

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Skocz do pozycji: 15.

Tytuł:: Effects of Preventive Treadmill Exercise on the Recovery of Metabolic and Mitochondrial Factors in the 6-Hydroxydopamine Rat Model of Parkinson's Disease.
Autorzy:: Rezaee Z; Department of Physical Education and Sport Science, University of Isfahan, Isfahan, Iran.
Marandi SM; Department of Physical Education and Sport Science, University of Isfahan, Isfahan, Iran. .; Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, HezarJerib Ave., Azadi Sq., P.O. Box: 81799-54359, Isfahan, Iran. .
Alaei H; Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. .; Department of Physiology, Faculty of Medicine, Isfahan University of Medical Sciences, University of Isfahan, Isfahan, Iran. .
Esfarjani F; Department of Physical Education and Sport Science, University of Isfahan, Isfahan, Iran.
Feyzollahzadeh S; Department of Laboratory Medical Sciences, School of Allied Medical Sciences, Urmia University of Medical Sciences, Urmia, Iran.; Pokaż więcej
Źródło:: Neurotoxicity research [Neurotox Res] 2019 May; Vol. 35 (4), pp. 908-917. Date of Electronic Publication: 2019 Feb 28.
Typ publikacji:: Journal Article
MeSH Terms:: Physical Conditioning, Animal*
Brain/*metabolism
Mitochondria/*metabolism
Parkinson Disease/*metabolism
Parkinson Disease/*prevention & control
Animals ; Disease Models, Animal ; Exercise Test ; Male ; Oxidopamine ; Parkinson Disease, Secondary/chemically induced ; Parkinson Disease, Secondary/prevention & control ; Rats, Wistar

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Skocz do pozycji: 16.

Tytuł:: Reduced erythrocytic CHCHD2 mRNA is associated with brain pathology of Parkinson's disease.
Autorzy:: Liu X; Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China.; Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, China.
Wang Q; Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China.
Yang Y; Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China.
Stewart T; Department of Pathology, School of Medicine, University of Washington, Seattle, WA, USA.
Shi M; Department of Pathology, School of Medicine, University of Washington, Seattle, WA, USA.
Soltys D; Department of Pathology, School of Medicine, University of Washington, Seattle, WA, USA.
Liu G; Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.; China National Clinical Research Center for Neurological Diseases, Beijing, 100070, China.
Thorland E; Department of Pathology, School of Medicine, University of Washington, Seattle, WA, USA.
Cilento EM; Department of Pathology, School of Medicine, University of Washington, Seattle, WA, USA.
Hou Y; The Affiliated High School of Peking University, Beijing, 100080, China.
Liu Z; Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China.
Feng T; Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. .; China National Clinical Research Center for Neurological Diseases, Beijing, 100070, China. .; Parkinson's Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China. .
Zhang J; Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China. .; Department of Pathology, The First Affiliated Hospital and School of Medicine, Zhejiang University, Hangzhou, China. .; China National Health and Disease Human Brain Tissue Resource Center, Hangzhou, China. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Mar 08; Vol. 9 (1), pp. 37. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: RNA, Messenger*/genetics
RNA, Messenger*/metabolism
Brain/*pathology
DNA-Binding Proteins/*blood
DNA-Binding Proteins/*genetics
Erythrocytes/*metabolism
Parkinson Disease/*genetics
Parkinson Disease/*pathology
Transcription Factors/*blood
Transcription Factors/*genetics
Aged ; Aged, 80 and over ; Animals ; Autopsy ; Biomarkers ; Brain/metabolism ; Cohort Studies ; Disease Models, Animal ; Female ; Humans ; Male ; Mice ; Mice, Transgenic ; Middle Aged ; Mitochondria/metabolism ; Mutation ; Parkinson Disease/blood ; Parkinson Disease/metabolism ; alpha-Synuclein/blood ; alpha-Synuclein/metabolism ; p300-CBP Transcription Factors/metabolism

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Skocz do pozycji: 17.

Tytuł:: Roles of the Functional Interaction between Brain Cholinergic and Dopaminergic Systems in the Pathogenesis and Treatment of Schizophrenia and Parkinson's Disease.
Autorzy:: Acharya S; Pharmacology Laboratory, College of Pharmacy, Chonnam National University, Gwang-Ju 61186, Korea.; Department of Pathology, College of Medicine, University of South Alabama, Mobile, AL 36617, USA.; Cancer Biology Program, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA.
Kim KM; Pharmacology Laboratory, College of Pharmacy, Chonnam National University, Gwang-Ju 61186, Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Apr 21; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 21.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Brain/*pathology
Cholinergic Agents/*metabolism
Dopamine/*metabolism
Dopaminergic Neurons/*metabolism
Parkinson Disease/*pathology
Schizophrenia/*pathology
Animals ; Brain/metabolism ; Humans ; Parkinson Disease/metabolism ; Parkinson Disease/therapy ; Schizophrenia/metabolism ; Schizophrenia/therapy

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Skocz do pozycji: 18.

Tytuł:: Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease.
Autorzy:: Reyes JF; Department of Biomedical and Clinical Sciences (BKV), Linköping University, 581 85, Linköping, Sweden. .; Department of Clinical Pathology, Linköping University, 581 85, Linköping, Sweden. .
Ekmark-Léwen S; Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden.
Perdiki M; Department of Biomedical and Clinical Sciences (BKV), Linköping University, 581 85, Linköping, Sweden.; Department of Clinical Pathology, Linköping University, 581 85, Linköping, Sweden.
Klingstedt T; Department of Physics, Chemistry and Biology, Linköping University, 581 83, Linköping, Sweden.
Hoffmann A; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Wiechec E; Department of Biomedical and Clinical Sciences (BKV), Linköping University, 581 85, Linköping, Sweden.; Department of Otorhinolaryngology, Anesthetics, Operations and Special Surgery Center, Linköping University, 581 85, Linköping, Sweden.
Nilsson P; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Solna, Sweden.
Nilsson KPR; Department of Physics, Chemistry and Biology, Linköping University, 581 83, Linköping, Sweden.
Alafuzoff I; Department of Pathology, Uppsala University Hospital, Uppsala, Sweden.
Ingelsson M; Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden.
Hallbeck M; Department of Biomedical and Clinical Sciences (BKV), Linköping University, 581 85, Linköping, Sweden.; Department of Clinical Pathology, Linköping University, 581 85, Linköping, Sweden.; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Mar 20; Vol. 9 (1), pp. 46. Date of Electronic Publication: 2021 Mar 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain/*metabolism
Brain/*pathology
Liver/*metabolism
Parkinson Disease/*metabolism
Parkinson Disease/*pathology
alpha-Synuclein/*metabolism
Aged ; Aged, 80 and over ; Animals ; Disease Models, Animal ; Female ; Humans ; Lewy Body Disease/metabolism ; Lewy Body Disease/pathology ; Lewy Body Disease/physiopathology ; Male ; Mice ; Mice, Transgenic ; Microscopy, Electron, Transmission ; Parkinson Disease/physiopathology ; Synucleinopathies/metabolism ; Synucleinopathies/pathology ; Synucleinopathies/physiopathology

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Skocz do pozycji: 19.

Tytuł:: Alterations in intrinsic functional networks in Parkinson's disease patients with depression: A resting-state functional magnetic resonance imaging study.
Autorzy:: Qiu YH; Department of Neurology, Guangdong Provincial Peoples' Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, China.
Huang ZH; Department of Neurology, Guangdong Provincial Peoples' Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, China.
Gao YY; Department of Neurology, Guangdong Provincial Peoples' Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, China.
Feng SJ; Department of Neurology, Guangdong Provincial Peoples' Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, China.
Huang B; Department of Radiology, Guangdong Provincial Peoples' Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Wang WY; Department of Neurology, Guangdong Provincial Peoples' Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, China.
Xu QH; Department of Neurology, Guangdong Provincial Peoples' Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, China.
Zhao JH; Department of Neurology, Guangdong Provincial Peoples' Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, China.
Zhang YH; Department of Neurology, Guangdong Provincial Peoples' Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, China.
Wang LM; Department of Neurology, Guangdong Provincial Peoples' Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, China.
Nie K; Department of Neurology, Guangdong Provincial Peoples' Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, China.
Wang LJ; Department of Neurology, Guangdong Provincial Peoples' Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, China.; Pokaż więcej
Źródło:: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2021 Mar; Vol. 27 (3), pp. 289-298. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain/*diagnostic imaging
Depression/*diagnostic imaging
Magnetic Resonance Imaging/*methods
Nerve Net/*diagnostic imaging
Parkinson Disease/*diagnostic imaging
Rest/*physiology
Adult ; Aged ; Aged, 80 and over ; Brain/physiopathology ; Cross-Sectional Studies ; Depression/epidemiology ; Depression/physiopathology ; Female ; Humans ; Male ; Mental Status and Dementia Tests ; Middle Aged ; Nerve Net/physiopathology ; Parkinson Disease/epidemiology ; Parkinson Disease/physiopathology

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Skocz do pozycji: 20.

Tytuł:: Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models.
Autorzy:: Jin JW; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Fan X; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Del Cid-Pellitero E; McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Liu XX; McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Zhou L; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Dai C; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Gibbs E; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
He W; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Li H; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Wu X; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Hill A; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Leavitt BR; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Cashman N; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Liu L; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Lu J; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Durcan TM; McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Dong Z; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. .; National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. .; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. .; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. .
Fon EA; McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada. .
Wang YT; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada. ytwang@brain.ubc.ca.; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2021 Feb 19; Vol. 4 (1), pp. 232. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antiparkinson Agents/*pharmacology
Brain/*drug effects
MPTP Poisoning/*drug therapy
Neurons/*drug effects
Parkinson Disease/*drug therapy
Peptides/*pharmacology
alpha-Synuclein/*metabolism
Animals ; Behavior, Animal/drug effects ; Brain/metabolism ; Brain/pathology ; Brain/physiopathology ; Disease Models, Animal ; Down-Regulation ; HEK293 Cells ; Humans ; MPTP Poisoning/genetics ; MPTP Poisoning/metabolism ; MPTP Poisoning/physiopathology ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Motor Activity/drug effects ; Mutation ; Neurons/metabolism ; Neurons/pathology ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Parkinson Disease/physiopathology ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; Rats, Sprague-Dawley ; alpha-Synuclein/genetics ; Mice ; Rats

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