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Wyszukujesz frazę ""Parkinson disease"" wg kryterium: Temat


Tytuł:
Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson's disease.
Autorzy:
Hideshima M; Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Kimura Y; Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Aguirre C; Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Kakuda K; Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Takeuchi T; Department of Neurology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-sayama, Osaka, 589-8511, Japan.; Department of Neurotherapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Choong CJ; Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Doi J; Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Nabekura K; Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Yamaguchi K; Global Center for Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Nakajima K; Global Center for Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Baba K; Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Nagano S; Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Department of Neurotherapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Goto Y; Global Center for Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Nagai Y; Department of Neurology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-sayama, Osaka, 589-8511, Japan.; Department of Neurotherapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Mochizuki H; Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. .
Ikenaka K; Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 10; Vol. 12 (1), pp. 351. Date of Electronic Publication: 2022 Jan 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
High-Throughput Screening Assays*
Protein Aggregation, Pathological*
Antiparkinson Agents/*pharmacology
Neurons/*drug effects
Parkinson Disease/*drug therapy
Tannins/*pharmacology
alpha-Synuclein/*metabolism
Animals ; Animals, Genetically Modified ; Antiparkinson Agents/toxicity ; Benzothiazoles/chemistry ; Biological Assay ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Disease Models, Animal ; Drug Repositioning ; HeLa Cells ; Humans ; Mice, Inbred C57BL ; Neurons/metabolism ; Neurons/pathology ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Protein Aggregates ; Spectrometry, Fluorescence ; Tannins/toxicity ; alpha-Synuclein/genetics ; alpha-Synuclein/ultrastructure ; Mice
Czasopismo naukowe
Tytuł:
Mercury is present in neurons and oligodendrocytes in regions of the brain affected by Parkinson's disease and co-localises with Lewy bodies.
Autorzy:
Pamphlett R; Sydney Medical School, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.; Department of Neuropathology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Bishop DP; Elemental Bio-Imaging Facility, School of Mathematical and Physical Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.
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Źródło:
PloS one [PLoS One] 2022 Jan 11; Vol. 17 (1), pp. e0262464. Date of Electronic Publication: 2022 Jan 11 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Brain/*pathology
Lewy Bodies/*pathology
Locus Coeruleus/*pathology
Mercury/*metabolism
Neurons/*pathology
Oligodendroglia/*pathology
Parkinson Disease/*pathology
Aged ; Aged, 80 and over ; Brain/metabolism ; Case-Control Studies ; Female ; Humans ; Lewy Bodies/metabolism ; Locus Coeruleus/metabolism ; Male ; Mercury/analysis ; Middle Aged ; Neurons/metabolism ; Oligodendroglia/metabolism ; Parkinson Disease/metabolism ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł:
Digging Deeper: Advancements in Visualization of Inhibitory Synapses in Neurodegenerative Disorders.
Autorzy:
Radulović S; Gottfried Schatz Research Center, Division of Cell Biology, Histology and Embryology, Medical University of Graz, 8010 Graz, Austria.
Sunkara S; Gottfried Schatz Research Center, Division of Cell Biology, Histology and Embryology, Medical University of Graz, 8010 Graz, Austria.
Maurer C; Gottfried Schatz Research Center, Division of Macroscopic and Clinical Anatomy, Medical University of Graz, 8010 Graz, Austria.
Leitinger G; Gottfried Schatz Research Center, Division of Cell Biology, Histology and Embryology, Medical University of Graz, 8010 Graz, Austria.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 18; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 18.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease/*diagnostic imaging
Brain/*diagnostic imaging
Neurons/*ultrastructure
Neuroprotective Agents/*therapeutic use
Parkinson Disease/*diagnostic imaging
Synapses/*ultrastructure
Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyotrophic Lateral Sclerosis/diagnostic imaging ; Amyotrophic Lateral Sclerosis/drug therapy ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Humans ; Huntington Disease/diagnostic imaging ; Huntington Disease/drug therapy ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Levodopa/therapeutic use ; Memantine/therapeutic use ; Microscopy, Electron/methods ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/metabolism ; Multiple Sclerosis/pathology ; Neuronal Plasticity/drug effects ; Neurons/drug effects ; Neurons/metabolism ; Neurotransmitter Agents/metabolism ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Synapses/drug effects ; Synapses/metabolism ; Synaptic Transmission/drug effects ; Tetrabenazine/therapeutic use
Czasopismo naukowe
Tytuł:
Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson's disease.
Autorzy:
Girard V; Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France.
Jollivet F; Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France.
Knittelfelder O; Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Celle M; Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France.
Arsac JN; Neurodegenerative Disease Unit; French Agency for Food, Environmental and Occupational Health & Safety Laboratory (Anses) of Lyon, University of Lyon, Lyon, France.
Chatelain G; Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France.
Van den Brink DM; Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France.; Plant Systems Physiology, Radboud Institute for Biological and Environmental Sciences, Radboud University, Nijmegen, The Netherlands.
Baron T; Neurodegenerative Disease Unit; French Agency for Food, Environmental and Occupational Health & Safety Laboratory (Anses) of Lyon, University of Lyon, Lyon, France.
Shevchenko A; Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Kühnlein RP; Institute of Molecular Biosciences, University of Graz, Graz, Austria.; BioTechMed-Graz, Graz, Austria.; Field of Excellence BioHealth-University of Graz, Graz, Austria.
Davoust N; Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France.
Mollereau B; Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France.
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Źródło:
PLoS genetics [PLoS Genet] 2021 Nov 17; Vol. 17 (11), pp. e1009921. Date of Electronic Publication: 2021 Nov 17 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lipid Metabolism/*genetics
Neurons/*metabolism
Parkinson Disease/*genetics
alpha-Synuclein/*genetics
Animals ; Animals, Genetically Modified/genetics ; Disease Models, Animal ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Humans ; Lipid Droplets/metabolism ; Lipolysis/genetics ; Membrane Transport Proteins/genetics ; Neuroblastoma/genetics ; Neurons/pathology ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Perilipin-2/genetics ; Protein Aggregation, Pathological/genetics ; Protein Aggregation, Pathological/pathology ; Proteolysis
Czasopismo naukowe
Tytuł:
Special Issue "Microglia Heterogeneity and Its Relevance for Translational Research".
Autorzy:
Michelucci A; Neuro-Immunology Group, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg.
Miron VE; MRC Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh EH16 4SB, UK.; United Kingdom Dementia Research Institute, The University of Edinburgh, Edinburgh EH16 4SB, UK.
Priller J; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh EH16 4SB, UK.; United Kingdom Dementia Research Institute, The University of Edinburgh, Edinburgh EH16 4SB, UK.; Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 16; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 16.
Typ publikacji:
Editorial
MeSH Terms:
Alzheimer Disease/*metabolism
Intracranial Aneurysm/*metabolism
Microglia/*metabolism
Neurons/*metabolism
Parkinson Disease/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Animals ; Cell Communication ; Central Nervous System/metabolism ; Central Nervous System/pathology ; Humans ; Intracranial Aneurysm/genetics ; Intracranial Aneurysm/pathology ; Microglia/pathology ; Neurons/pathology ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Translational Research, Biomedical/trends
Opinia redakcyjna
Tytuł:
Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases.
Autorzy:
Foliaki ST; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.
Schwarz B; Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.
Groveman BR; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.
Walters RO; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.
Ferreira NC; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.
Orrù CD; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.
Smith A; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.
Wood A; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.
Schmit OM; Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.
Freitag P; Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.
Yuan J; Departments of Pathology and Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Zou W; Departments of Pathology and Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Bosio CM; Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.
Carroll JA; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.
Haigh CL; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA. .
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Źródło:
Molecular brain [Mol Brain] 2021 Oct 11; Vol. 14 (1), pp. 156. Date of Electronic Publication: 2021 Oct 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Creutzfeldt-Jakob Syndrome/*physiopathology
Down Syndrome/*physiopathology
Neurons/*physiology
Organoids/*physiology
Parkinson Disease/*physiopathology
Action Potentials ; Brain Waves ; Cell Differentiation ; Creutzfeldt-Jakob Syndrome/genetics ; Creutzfeldt-Jakob Syndrome/pathology ; Down Syndrome/genetics ; Down Syndrome/pathology ; Fibroblasts/cytology ; Humans ; Induced Pluripotent Stem Cells/physiology ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Mutation ; Nerve Net/physiology ; Neurosteroids/pharmacology ; Neurotransmitter Agents/metabolism ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Prion Proteins/genetics ; Receptors, Neurotransmitter/metabolism ; Synapses/metabolism
Czasopismo naukowe
Tytuł:
LncRNA JHDM1D-AS1 Suppresses MPP + -Induced Neuronal Injury in Parkinson's Disease via miR-134-5p/PIK3R3 Axis.
Autorzy:
Wang C; Department of Neurology, Guta District, The First Affiliated Hospital of Jinzhou Medical University, No.2, Section 5, UniversityLiaoning Province, 121000, China.
Zhang H; Department of Neurology, Guta District, The First Affiliated Hospital of Jinzhou Medical University, No.2, Section 5, UniversityLiaoning Province, 121000, China.
Li J; Department of Neurology, Guta District, The First Affiliated Hospital of Jinzhou Medical University, No.2, Section 5, UniversityLiaoning Province, 121000, China. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2021 Dec; Vol. 39 (6), pp. 1771-1781. Date of Electronic Publication: 2021 Nov 13.
Typ publikacji:
Journal Article
MeSH Terms:
Jumonji Domain-Containing Histone Demethylases/*metabolism
MicroRNAs/*metabolism
Neurons/*drug effects
Parkinson Disease/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
RNA, Long Noncoding/*metabolism
1-Methyl-4-phenylpyridinium/antagonists & inhibitors ; 1-Methyl-4-phenylpyridinium/pharmacology ; Blotting, Western ; Cell Line, Tumor ; Flow Cytometry ; Humans ; Parkinson Disease/drug therapy ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł:
Molecular events underlying the cell-to-cell transmission of α-synuclein.
Autorzy:
Choi YR; Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea.; Center for Convergence Research of Neurological Disorders, Ajou University School of Medicine, Suwon, Korea.; BK21 Plus Program, Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Korea.
Park SJ; Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea.; Center for Convergence Research of Neurological Disorders, Ajou University School of Medicine, Suwon, Korea.; Department of Thoracic and Cardiovascular Surgery, Ajou University School of Medicine, Suwon, Korea.
Park SM; Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea.; Center for Convergence Research of Neurological Disorders, Ajou University School of Medicine, Suwon, Korea.; BK21 Plus Program, Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Korea.
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Źródło:
The FEBS journal [FEBS J] 2021 Dec; Vol. 288 (23), pp. 6593-6602. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Astrocytes/*metabolism
Lewy Bodies/*metabolism
Microglia/*metabolism
Neurons/*metabolism
Parkinson Disease/*metabolism
alpha-Synuclein/*metabolism
Animals ; Astrocytes/cytology ; Exosomes/metabolism ; Humans ; Microglia/cytology ; Neurons/cytology ; Parkinson Disease/pathology ; Protein Transport
Czasopismo naukowe
Tytuł:
Differences in Neuronal Numbers, Morphology, and Developmental Apoptosis in Mice Nigra Provide Experimental Evidence of Ontogenic Origin of Vulnerability to Parkinson's Disease.
Autorzy:
Vidyadhara DJ; Department of Neurophysiology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, 560029, India.; Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Yarreiphang H; Department of Neurophysiology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, 560029, India.
Raju TR; Department of Neurophysiology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, 560029, India.
Alladi PA; Department of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, 560029, India. .; Formerly at Department of Neurophysiology, National Institute of Mental Health and Neuro-Sciences, Hosur Road, Bangalore, India. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2021 Dec; Vol. 39 (6), pp. 1892-1907. Date of Electronic Publication: 2021 Nov 11.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Neurons/*pathology
Parkinson Disease/*etiology
Substantia Nigra/*pathology
Animals ; Animals, Newborn/anatomy & histology ; Cell Count ; Disease Susceptibility/pathology ; Female ; In Situ Nick-End Labeling ; Male ; Mice ; Mice, Inbred C57BL ; Parkinson Disease/pathology ; Substantia Nigra/cytology
Czasopismo naukowe
Tytuł:
Exploring the Role of Orexinergic Neurons in Parkinson's Disease.
Autorzy:
Kumar S; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Behl T; Chitkara College of Pharmacy, Chitkara University, Punjab, India. .
Sehgal A; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Singh S; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Sharma N; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Bhatia S; Natural & Medical Sciences Research Centre, University of Nizwa, Nizwa, Oman.; Amity Institute of Pharmacy, Amity University, Haryana, India.
Al-Harassi A; Natural & Medical Sciences Research Centre, University of Nizwa, Nizwa, Oman.
Abdel-Daim MM; Department of Pharmaceutical Sciences, Batterjee Medical College, Pharmacy Program, Jeddah, Saudi Arabia.; Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
Bungau S; Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
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Źródło:
Neurotoxicity research [Neurotox Res] 2021 Dec; Vol. 39 (6), pp. 2141-2153. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neurons/*metabolism
Orexins/*physiology
Parkinson Disease/*etiology
Animals ; Humans ; Neurons/pathology ; Orexins/metabolism ; Parkinson Disease/pathology
Czasopismo naukowe
Tytuł:
Population-specific neuromodulation prolongs therapeutic benefits of deep brain stimulation.
Autorzy:
Spix TA; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
Nanivadekar S; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.; Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Toong N; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
Kaplow IM; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA.
Isett BR; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
Goksen Y; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.
Pfenning AR; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA.
Gittis AH; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Oct 08; Vol. 374 (6564), pp. 201-206. Date of Electronic Publication: 2021 Oct 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Deep Brain Stimulation/*methods
Dopamine/*deficiency
Globus Pallidus/*physiopathology
Neurons/*physiology
Parkinson Disease/*therapy
Transcutaneous Electric Nerve Stimulation/*methods
Animals ; Disease Models, Animal ; Dopamine/genetics ; Female ; Globus Pallidus/cytology ; Male ; Mice ; Mice, Inbred C57BL ; Optogenetics ; Parkinson Disease/physiopathology ; Subthalamic Nucleus/cytology ; Subthalamic Nucleus/physiopathology ; Synapses/physiology
Czasopismo naukowe
Tytuł:
The intracellular milieu of Parkinson's disease patient brain cells modulates alpha-synuclein protein aggregation.
Autorzy:
Gustavsson N; Medical Microspectroscopy, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Savchenko E; Stem Cell Laboratory for CNS Disease Modelling, Department of Experimental Medical Science, BMC D10, Lund University, Lund, Sweden.
Klementieva O; Medical Microspectroscopy, Department of Experimental Medical Science, Lund University, Lund, Sweden. .
Roybon L; Stem Cell Laboratory for CNS Disease Modelling, Department of Experimental Medical Science, BMC D10, Lund University, Lund, Sweden. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Sep 16; Vol. 9 (1), pp. 153. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain/*metabolism
Intracellular Fluid/*metabolism
Neurons/*metabolism
Parkinson Disease/*metabolism
Protein Aggregates/*physiology
alpha-Synuclein/*metabolism
Brain/pathology ; Female ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Male ; Neurons/pathology ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Spectroscopy, Fourier Transform Infrared/methods ; alpha-Synuclein/genetics
Czasopismo naukowe
Tytuł:
Queuine, a bacterial-derived hypermodified nucleobase, shows protection in in vitro models of neurodegeneration.
Autorzy:
Richard P; Stellate Therapeutics Inc., JLABS @ NYC, New York, New York, United States of America.
Kozlowski L; Stellate Therapeutics SAS, Paris, France.
Guillorit H; Stellate Therapeutics SAS, Paris, France.; Institut de Génomique Fonctionnelle, Montpellier, France.
Garnier P; Stellate Therapeutics SAS, Paris, France.
McKnight NC; Stellate Therapeutics Inc., JLABS @ NYC, New York, New York, United States of America.
Danchin A; Kodikos Labs, Institut Cochin, Paris, France.
Manière X; Stellate Therapeutics SAS, Paris, France.
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Źródło:
PloS one [PLoS One] 2021 Aug 11; Vol. 16 (8), pp. e0253216. Date of Electronic Publication: 2021 Aug 11 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease/*drug therapy
Guanine/*analogs & derivatives
Neurons/*drug effects
Neuroprotective Agents/*therapeutic use
Parkinson Disease/*drug therapy
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Cells, Cultured ; Disease Models, Animal ; Female ; Guanine/pharmacology ; Guanine/therapeutic use ; Humans ; Mice ; Neurons/metabolism ; Neurons/pathology ; Neuroprotective Agents/pharmacology ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Rats, Wistar ; alpha-Synuclein/metabolism ; Rats
Czasopismo naukowe
Tytuł:
The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson's Disease.
Autorzy:
Leites EP; Instituto de Medicina Molecular-João Lobo Antunes, Faculdade de Lisboa, Universidade de Lisboa, 1649-028 Lisbon, Portugal.
Morais VA; Instituto de Medicina Molecular-João Lobo Antunes, Faculdade de Lisboa, Universidade de Lisboa, 1649-028 Lisbon, Portugal.
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Źródło:
Cells [Cells] 2021 Jun 05; Vol. 10 (6). Date of Electronic Publication: 2021 Jun 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Astrocytes/*enzymology
Microglia/*enzymology
Mitochondria/*enzymology
Neurons/*enzymology
Parkinson Disease/*enzymology
Protein Kinases/*metabolism
Animals ; Astrocytes/pathology ; Brain/enzymology ; Brain/pathology ; Humans ; Microglia/pathology ; Mitochondria/pathology ; Neurons/pathology ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Protein Kinases/genetics
Czasopismo naukowe
Tytuł:
Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson's Disease.
Autorzy:
Portz P; Department of Medical Cell Biology, Institute for Anatomy and Cell Biology, University of Heidelberg, 69120 Heidelberg, Germany.
Lee MK; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.; Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
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Źródło:
Cells [Cells] 2021 Apr 13; Vol. 10 (4). Date of Electronic Publication: 2021 Apr 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Dynamins/*genetics
GTP Phosphohydrolases/*genetics
Mitochondria/*genetics
Neurons/*metabolism
Parkinson Disease/*genetics
alpha-Synuclein/*genetics
Animals ; Brain Stem/metabolism ; Brain Stem/pathology ; Cerebral Cortex/metabolism ; Cerebral Cortex/pathology ; Disease Models, Animal ; Dynamins/metabolism ; GTP Phosphohydrolases/metabolism ; Gene Expression Regulation ; Humans ; Mice ; Mice, Transgenic ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Dynamics/genetics ; Mutation ; Neurons/pathology ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Phosphorylation ; Signal Transduction ; Spinal Cord/metabolism ; Spinal Cord/pathology ; alpha-Synuclein/metabolism
Czasopismo naukowe
Tytuł:
Role of Receptor Protein Tyrosine Phosphatase β/ζ in Neuron-Microglia Communication in a Cellular Model of Parkinson's Disease.
Autorzy:
Del Campo M; Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925 Alcorcón, Spain.
Fernández-Calle R; Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925 Alcorcón, Spain.
Vicente-Rodríguez M; Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925 Alcorcón, Spain.
Martín Martínez S; Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925 Alcorcón, Spain.
Gramage E; Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925 Alcorcón, Spain.
Zapico JM; Departamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925 Alcorcón, Spain.
Haro M; Departamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925 Alcorcón, Spain.
Herradon G; Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925 Alcorcón, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 22; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 22.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Communication*
Carrier Proteins/*metabolism
Cytokines/*metabolism
Microglia/*metabolism
Neurons/*metabolism
Parkinson Disease/*metabolism
Receptor-Like Protein Tyrosine Phosphatases, Class 5/*metabolism
Animals ; Humans ; Inflammation/metabolism ; Inflammation/physiopathology ; Mice ; Microglia/physiology ; Models, Biological ; Neurons/physiology ; Parkinson Disease/physiopathology ; Receptor-Like Protein Tyrosine Phosphatases, Class 5/physiology ; Signal Transduction
Czasopismo naukowe
Tytuł:
Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo.
Autorzy:
Sarkar S; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Massachusetts, Boston, USA.
Bardai F; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Massachusetts, Boston, USA.
Olsen AL; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Massachusetts, Boston, USA.
Lohr KM; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Massachusetts, Boston, USA.
Zhang YY; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Massachusetts, Boston, USA.
Feany MB; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Massachusetts, Boston, USA. mel_.
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Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2021 May 24; Vol. 16 (1), pp. 33. Date of Electronic Publication: 2021 May 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Actins/*metabolism
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*metabolism
Neurons/*metabolism
Parkinson Disease/*metabolism
alpha-Synuclein/*toxicity
Animals ; Drosophila ; Gene Knock-In Techniques ; Humans ; Mice ; Mice, Inbred C57BL ; Neurons/pathology ; Parkinson Disease/pathology
Czasopismo naukowe
Tytuł:
Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease.
Autorzy:
Ingles-Prieto A; Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Austria.
Furthmann N; Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.
Crossman SH; Australian Regenerative Medicine Institute (ARMI), Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton/Melbourne, Australia.; European Molecular Biology Laboratory Australia (EMBL Australia), Monash University, Clayton/Melbourne, Australia.
Tichy AM; Australian Regenerative Medicine Institute (ARMI), Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton/Melbourne, Australia.; European Molecular Biology Laboratory Australia (EMBL Australia), Monash University, Clayton/Melbourne, Australia.
Hoyer N; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Petersen M; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Zheden V; Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Austria.
Biebl J; Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Austria.
Reichhart E; Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Austria.; Australian Regenerative Medicine Institute (ARMI), Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton/Melbourne, Australia.; European Molecular Biology Laboratory Australia (EMBL Australia), Monash University, Clayton/Melbourne, Australia.
Gyoergy A; Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Austria.
Siekhaus DE; Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Austria.
Soba P; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Winklhofer KF; Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.
Janovjak H; Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Austria.; Australian Regenerative Medicine Institute (ARMI), Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton/Melbourne, Australia.; European Molecular Biology Laboratory Australia (EMBL Australia), Monash University, Clayton/Melbourne, Australia.
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Źródło:
PLoS genetics [PLoS Genet] 2021 Apr 15; Vol. 17 (4), pp. e1009479. Date of Electronic Publication: 2021 Apr 15 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drosophila Proteins/*genetics
Mitochondria/*genetics
Neurons/*metabolism
Parkinson Disease/*genetics
Protein Serine-Threonine Kinases/*genetics
Animals ; Disease Models, Animal ; Drosophila melanogaster/genetics ; Humans ; Light ; Loss of Function Mutation/genetics ; Mitochondria/radiation effects ; Neurons/pathology ; Neurons/radiation effects ; Optogenetics/methods ; Parkinson Disease/pathology ; Phosphatidylinositol 3-Kinases/genetics ; Retina/growth & development ; Retina/metabolism ; Signal Transduction/genetics ; Transfection
Czasopismo naukowe
Tytuł:
Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models.
Autorzy:
Jin JW; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Fan X; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Del Cid-Pellitero E; McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Liu XX; McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Zhou L; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Dai C; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Gibbs E; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
He W; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Li H; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Wu X; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Hill A; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Leavitt BR; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Cashman N; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Liu L; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Lu J; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Durcan TM; McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Dong Z; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. .; National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. .; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. .; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. .
Fon EA; McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada. .
Wang YT; The Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British Columbia, Vancouver, BC, Canada. .
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Źródło:
Communications biology [Commun Biol] 2021 Feb 19; Vol. 4 (1), pp. 232. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antiparkinson Agents/*pharmacology
Brain/*drug effects
MPTP Poisoning/*drug therapy
Neurons/*drug effects
Parkinson Disease/*drug therapy
Peptides/*pharmacology
alpha-Synuclein/*metabolism
Animals ; Behavior, Animal/drug effects ; Brain/metabolism ; Brain/pathology ; Brain/physiopathology ; Disease Models, Animal ; Down-Regulation ; HEK293 Cells ; Humans ; MPTP Poisoning/genetics ; MPTP Poisoning/metabolism ; MPTP Poisoning/physiopathology ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Motor Activity/drug effects ; Mutation ; Neurons/metabolism ; Neurons/pathology ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Parkinson Disease/physiopathology ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; Rats, Sprague-Dawley ; alpha-Synuclein/genetics ; Mice ; Rats
Czasopismo naukowe
Tytuł:
Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles.
Autorzy:
Jewett KA; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.; Department of Biology, Juniata College, Huntingdon, Pennsylvania, United States of America.
Thomas RE; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
Phan CQ; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
Lin B; VA Puget Sound Healthcare System, Seattle, Washington, United States of America.
Milstein G; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
Yu S; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.; VA Puget Sound Healthcare System, Seattle, Washington, United States of America.
Bettcher LF; Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, United States of America.
Neto FC; Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, United States of America.
Djukovic D; Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, United States of America.
Raftery D; Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, United States of America.
Pallanck LJ; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
Davis MY; VA Puget Sound Healthcare System, Seattle, Washington, United States of America.; Department of Neurology, University of Washington, Seattle, Washington, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2021 Feb 04; Vol. 17 (2), pp. e1008859. Date of Electronic Publication: 2021 Feb 04 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Drosophila melanogaster/*metabolism
Extracellular Vesicles/*metabolism
Glucosylceramidase/*metabolism
Neurons/*metabolism
Parkinson Disease/*metabolism
Protein Aggregation, Pathological/*metabolism
Animals ; Biological Transport ; Brain/metabolism ; Ceramides/metabolism ; DNA-Binding Proteins/metabolism ; Disease Models, Animal ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Gene Knockdown Techniques ; Glucosylceramidase/deficiency ; Glucosylceramidase/genetics ; Glucosylceramides/metabolism ; Lipidomics ; Muscles/metabolism ; Mutation ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Protein Aggregation, Pathological/genetics ; Proteome/genetics ; Proteome/metabolism ; RNA Interference
Czasopismo naukowe

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