- Tytuł:
-
Two-step screening method to identify α-synuclein aggregation inhibitors for
Parkinson 'sdisease . - Autorzy:
- Źródło:
- Scientific reports [Sci Rep] 2022 Jan 10; Vol. 12 (1), pp. 351. Date of Electronic Publication: 2022 Jan 10.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
High-Throughput Screening Assays*
Protein Aggregation, Pathological*
Antiparkinson Agents/*pharmacologyNeurons /*drug effectsParkinson Disease /*drug therapy
Tannins/*pharmacology
alpha-Synuclein/*metabolism
Animals ; Animals, Genetically Modified ; Antiparkinson Agents/toxicity ; Benzothiazoles/chemistry ; Biological Assay ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ;Disease Models, Animal ; Drug Repositioning ; HeLa Cells ; Humans ; Mice, Inbred C57BL ;Neurons /metabolism ;Neurons /pathology ;Parkinson Disease /metabolism ;Parkinson Disease /pathology ; Protein Aggregates ; Spectrometry, Fluorescence ; Tannins/toxicity ; alpha-Synuclein/genetics ; alpha-Synuclein/ultrastructure ; Mice
Czasopismo naukowe