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Tytuł :
[Age-related differences in sleep disturbances in rat models of preclinical Parkinson's disease].
Autorzy :
Ekimova IV; Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, St-Petersburg, Russia.
Guzeev MA; Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, St-Petersburg, Russia.
Simonova VV; Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, St-Petersburg, Russia.
Pastukhov YF; Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, St-Petersburg, Russia.
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Transliterated Title :
Vozrastnye osobennosti narushenii sna v modelyakh doklinicheskoi stadii bolezni Parkinsona u krys.
Źródło :
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2020; Vol. 120 (9. Vyp. 2), pp. 26-33.
Typ publikacji :
Journal Article
MeSH Terms :
Disorders of Excessive Somnolence*
Parkinson Disease*
Sleep Wake Disorders*/etiology
Animals ; Humans ; Middle Aged ; Neurons ; Rats ; Wakefulness
Czasopismo naukowe
Tytuł :
[U-133, a heat shock proteins inducer, precludes sleep disturbances in a model of the preclinical stage of Parkinson's disease in aged rats.]
Autorzy :
Pastukhov YF; I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, 44 pr. Toreza, St. Petersburg 194223, Russian Federation, e-mail: .
Simonova VV; I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, 44 pr. Toreza, St. Petersburg 194223, Russian Federation, e-mail: .
Shemyakova TS; I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, 44 pr. Toreza, St. Petersburg 194223, Russian Federation, e-mail: .
Guzeev MA; I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, 44 pr. Toreza, St. Petersburg 194223, Russian Federation, e-mail: .
Polonik SG; G.B.Elyakov Pacific Institute of Bioorganic Chemistry, 159 str. 100-letyia Vladivostoka, Vladivostok 690022, Russian Federation.
Ekimova IV; I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, 44 pr. Toreza, St. Petersburg 194223, Russian Federation, e-mail: .
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Źródło :
Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2019; Vol. 32 (6), pp. 935-940.
Typ publikacji :
Journal Article
MeSH Terms :
Heat-Shock Proteins/*metabolism
Sleep Wake Disorders/*metabolism
Animals ; Disease Models, Animal ; Parkinson Disease ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson's disease.
Autorzy :
Ekimova IV; Laboratory of Comparative Thermophysiology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences, pr. Maurice Thorez, 44, St. Petersburg 194223, Russia. Electronic address: .
Plaksina DV; Laboratory of Comparative Thermophysiology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences, pr. Maurice Thorez, 44, St. Petersburg 194223, Russia.
Pastukhov YF; Laboratory of Comparative Thermophysiology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences, pr. Maurice Thorez, 44, St. Petersburg 194223, Russia.
Lapshina KV; Laboratory of Comparative Thermophysiology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences, pr. Maurice Thorez, 44, St. Petersburg 194223, Russia.
Lazarev VF; Cell Protection Mechanisms Laboratory, Institute of Cytology Russian of Academy of Sciences, Tikhoretsky pr., 4, St. Petersburg 194064, Russia.
Mikhaylova ER; Cell Protection Mechanisms Laboratory, Institute of Cytology Russian of Academy of Sciences, Tikhoretsky pr., 4, St. Petersburg 194064, Russia.
Polonik SG; G.B.Elyakov Pacific Institute of Bioorganic Chemistry of Far East Branch of Russian Academy of Sciences, pr. 100 let Vladivostoku 159, Vladivostok 690022, Russia.
Pani B; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine NY, NY 10016, USA.
Margulis BA; Cell Protection Mechanisms Laboratory, Institute of Cytology Russian of Academy of Sciences, Tikhoretsky pr., 4, St. Petersburg 194064, Russia.
Guzhova IV; Cell Protection Mechanisms Laboratory, Institute of Cytology Russian of Academy of Sciences, Tikhoretsky pr., 4, St. Petersburg 194064, Russia. Electronic address: .
Nudler E; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine NY, NY 10016, USA; Howard Hughes Medical Institute, New York University School of Medicine NY, NY 10016, USA. Electronic address: .
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Źródło :
Experimental neurology [Exp Neurol] 2018 Aug; Vol. 306, pp. 199-208. Date of Electronic Publication: 2018 Apr 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiparkinson Agents/*therapeutic use
Cetirizine/*therapeutic use
Heat Shock Transcription Factors/*agonists
Neuroprotective Agents/*therapeutic use
Parkinson Disease/*drug therapy
Animals ; Gene Knockdown Techniques ; HSP70 Heat-Shock Proteins/biosynthesis ; HSP70 Heat-Shock Proteins/genetics ; Male ; Microglia/drug effects ; Nerve Degeneration/genetics ; Parkinson Disease/psychology ; Psychomotor Performance ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
[Changes in characteristics of sleep-wake cycle and motor activity at the preclinical stage of Parkinson's disease in old rats].
Autorzy :
Simonova VV; Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, St. Petersburg, Russia.
Guzeev MA; Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, St. Petersburg, Russia.
Karpenko MN; Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, St. Petersburg, Russia.
Shemyakova TS; Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, St. Petersburg, Russia.
Ekimova IV; Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, St. Petersburg, Russia.
Pastukhov YF; Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, St. Petersburg, Russia.
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Transliterated Title :
Izmeneniia kharakteristik sna i summarnoĭ dvigatel'noĭ aktivnosti v modeli doklinicheskoĭ stadii bolezni Parkinsona u starykh krys.
Źródło :
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2018; Vol. 118 (4. Vyp. 2), pp. 14-20.
Typ publikacji :
Journal Article
MeSH Terms :
Motor Activity*
Parkinson Disease*/complications
Sleep Wake Disorders*/etiology
Animals ; Disease Models, Animal ; Dopamine/metabolism ; Humans ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
[Parkinson's disease and aging.]
Autorzy :
Chesnokova AY; I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS, 44, Toreza pr., St. Petersburg 194223, Russian Federation; e-mail: , .
Ekimova IV; I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS, 44, Toreza pr., St. Petersburg 194223, Russian Federation; e-mail: , .
Pastukhov YF; I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS, 44, Toreza pr., St. Petersburg 194223, Russian Federation; e-mail: , .
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Źródło :
Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2018; Vol. 31 (5), pp. 668-678.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Aging*
Parkinson Disease*
Aged ; Humans
Czasopismo naukowe
Tytuł :
Impairment of non-associative learning in a rat experimental model of preclinical stage of Parkinson's disease.
Autorzy :
Abdurasulova IN; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia. .; Institute of Experimental Medicine, St. Petersburg, Russia. .
Ekimova IV; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
Matsulevich AV; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.; Institute of Experimental Medicine, St. Petersburg, Russia.
Gazizova AR; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
Klimenko VM; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.; Institute of Experimental Medicine, St. Petersburg, Russia.
Pastukhov YF; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
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Źródło :
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections [Dokl Biol Sci] 2017 Sep; Vol. 476 (1), pp. 188-190. Date of Electronic Publication: 2017 Nov 04.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcysteine/*analogs & derivatives
Cognitive Dysfunction/*physiopathology
Learning/*physiology
Parkinson Disease, Secondary/*physiopathology
Acetylcysteine/administration & dosage ; Acetylcysteine/toxicity ; Animals ; Axons/drug effects ; Axons/physiology ; Behavior, Animal/drug effects ; Cognitive Dysfunction/chemically induced ; Disease Models, Animal ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/pathology ; Humans ; Learning/drug effects ; Mesencephalon/drug effects ; Mesencephalon/physiopathology ; Parkinson Disease, Secondary/chemically induced ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/physiopathology ; Rats
Czasopismo naukowe
Tytuł :
[SLOW-WAVE SLEEP AND MOLECULAR CHAPERONES].
Autorzy :
Pastukhov YF
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Źródło :
Zhurnal evoliutsionnoi biokhimii i fiziologii [Zh Evol Biokhim Fiziol] 2016 Jan-Feb; Vol. 52 (1), pp. 79-90.
Typ publikacji :
English Abstract; Journal Article; Review
MeSH Terms :
Sleep Stages*
HSP40 Heat-Shock Proteins/*metabolism
HSP70 Heat-Shock Proteins/*metabolism
Animals ; Brain/metabolism ; Brain/physiology ; HSP40 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/genetics ; Humans
Czasopismo naukowe
Tytuł :
[Role of adenosine A(2A) receptors of preoptical area in realization of somnogenic effect of protein 70 kDa in pigeons].
Autorzy :
Ekimova IV
Pastukhov YF
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Źródło :
Zhurnal evoliutsionnoi biokhimii i fiziologii [Zh Evol Biokhim Fiziol] 2014 Nov-Dec; Vol. 50 (6), pp. 428-34.
Typ publikacji :
English Abstract; Journal Article
MeSH Terms :
HSP70 Heat-Shock Proteins/*pharmacology
Preoptic Area/*metabolism
Receptor, Adenosine A2A/*metabolism
Sleep Stages/*drug effects
Adenosine A2 Receptor Antagonists/pharmacology ; Animals ; Caffeine/pharmacology ; Columbidae ; Female ; Male ; Preoptic Area/physiology
Czasopismo naukowe
Tytuł :
Exogenous protein HSP70 blocks neurodegeneration in the rat model of the clinical stage of Parkinson's disease.
Autorzy :
Pastukhov YF; Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia, .
Plaksina DV
Lapshina KV
Guzhova IV
Ekimova IV
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Źródło :
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections [Dokl Biol Sci] 2014 Jul; Vol. 457 (1), pp. 225-7. Date of Electronic Publication: 2014 Aug 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HSP70 Heat-Shock Proteins/*therapeutic use
Neuroprotective Agents/*therapeutic use
Parkinson Disease, Secondary/*drug therapy
Acetylcysteine/analogs & derivatives ; Acetylcysteine/toxicity ; Animals ; HSP70 Heat-Shock Proteins/pharmacokinetics ; Male ; Neuroprotective Agents/pharmacokinetics ; Parkinson Disease, Secondary/etiology ; Protease Inhibitors/toxicity ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Exogenous protein Hsp70/Hsc70 can penetrate into brain structures and attenuate the severity of chemically-induced seizures.
Autorzy :
Ekimova IV; Laboratory of Comparative Thermophysiology, IM Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
Nitsinskaya LE
Romanova IV
Pastukhov YF
Margulis BA
Guzhova IV
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Źródło :
Journal of neurochemistry [J Neurochem] 2010 Nov; Vol. 115 (4), pp. 1035-44. Date of Electronic Publication: 2010 Oct 07.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*metabolism
HSC70 Heat-Shock Proteins/*physiology
HSP70 Heat-Shock Proteins/*physiology
Seizures/*metabolism
Seizures/*prevention & control
Animals ; Anticonvulsants/metabolism ; Anticonvulsants/therapeutic use ; Brain/drug effects ; Brain/physiopathology ; Cattle ; HSC70 Heat-Shock Proteins/therapeutic use ; HSP70 Heat-Shock Proteins/therapeutic use ; Humans ; Male ; N-Methylaspartate/toxicity ; Pentylenetetrazole/toxicity ; Prospective Studies ; Protein Transport/drug effects ; Protein Transport/physiology ; Rats ; Rats, Wistar ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use ; Seizures/chemically induced ; Seizures/physiopathology ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Microinjection of 70-kDal heat shock protein into the oral reticular nucleus of the pons suppresses rapid eye movement sleep in pigeons.
Autorzy :
Gusel'nikova EA; I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 44 M. Torez Prospekt, 194223, St. Petersburg, Russia. />Pastukhov YF
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Źródło :
Neuroscience and behavioral physiology [Neurosci Behav Physiol] 2009 Mar; Vol. 39 (3), pp. 289-96. Date of Electronic Publication: 2009 Feb 21.
Typ publikacji :
Journal Article
MeSH Terms :
HSP70 Heat-Shock Proteins/*metabolism
Reticular Formation/*physiology
Sleep, REM/*physiology
Animals ; Body Temperature/drug effects ; Columbidae ; Electroencephalography ; Female ; HSP70 Heat-Shock Proteins/physiology ; Male ; Microinjections ; Muscle Contraction ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/physiology ; Neurons/drug effects ; Neurons/physiology ; Receptors, GABA-A/metabolism ; Sleep Stages/drug effects ; Sleep Stages/physiology ; Sleep, REM/drug effects
Czasopismo naukowe
Tytuł :
Role of the cholinergic mechanisms of the ventrolateral preoptic area of the hypothalamus in regulating the state of sleep and waking in pigeons.
Autorzy :
Komarova TG; I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia. />Ekimova IV
Pastukhov YF
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Źródło :
Neuroscience and behavioral physiology [Neurosci Behav Physiol] 2008 Mar; Vol. 38 (3), pp. 245-52.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Preoptic Area/*metabolism
Receptors, Muscarinic/*metabolism
Sleep/*physiology
Wakefulness/*physiology
Animals ; Arecoline/pharmacology ; Benactyzine/pharmacology ; Body Temperature Regulation/physiology ; Cholinergic Agents/pharmacology ; Columbidae ; Dose-Response Relationship, Drug ; Electroencephalography ; Female ; Male ; Mecamylamine/pharmacology ; Microinjections ; Nicotine/pharmacology ; Preoptic Area/drug effects ; Receptors, Muscarinic/drug effects ; Receptors, Nicotinic/drug effects ; Receptors, Nicotinic/metabolism ; Sleep/drug effects ; Wakefulness/drug effects
Czasopismo naukowe
Tytuł :
Effects of exogenous heat shock protein 70 and quercetin on NMDA-induced seizures.
Autorzy :
Ekimova IV; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toresa 44, St. Petersburg, 194223, Russia.
Komarova TG
Nitsinskaya LE
Pastukhov YF
Guzhova IV
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Źródło :
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections [Dokl Biol Sci] 2008 Jan-Feb; Vol. 418, pp. 13-5. Date of Electronic Publication: 2011 Jan 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anticonvulsants/*therapeutic use
HSP70 Heat-Shock Proteins/*therapeutic use
Quercetin/*therapeutic use
Seizures/*drug therapy
Animals ; Anticonvulsants/administration & dosage ; HSP70 Heat-Shock Proteins/administration & dosage ; Injections, Intraventricular ; Male ; N-Methylaspartate/toxicity ; Quercetin/administration & dosage ; Rats ; Rats, Wistar ; Seizures/chemically induced
Czasopismo naukowe
Tytuł :
Lipopolysaccharide-free 70-kDa heat shock protein has hypotherimic and somnogenic effects.
Autorzy :
Pastukhov YF; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg, 194223 Russia.
Ekimova IV
Hudik KA
Guzhova IV
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Źródło :
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections [Dokl Biol Sci] 2005 May-Jun; Vol. 402, pp. 167-70.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*drug effects
Brain/*physiology
Columbidae/*physiology
HSP70 Heat-Shock Proteins/*administration & dosage
Hypothermia, Induced/*methods
Wakefulness/*drug effects
Wakefulness/*physiology
Animals ; Body Temperature/drug effects ; Body Temperature/physiology ; HSP70 Heat-Shock Proteins/chemistry ; HSP70 Heat-Shock Proteins/isolation & purification ; Lipopolysaccharides/isolation & purification ; Microinjections
Czasopismo naukowe

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