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Tytuł :
Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Autorzy :
Ruan Z; Van Andel Institute, Grand Rapids, MI, USA.
Orozco IJ; Van Andel Institute, Grand Rapids, MI, USA.
Du J; Van Andel Institute, Grand Rapids, MI, USA. .
Lü W; Van Andel Institute, Grand Rapids, MI, USA. .
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Źródło :
Nature [Nature] 2020 Aug; Vol. 584 (7822), pp. 646-651. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Ion Channel Gating*/drug effects
Patch-Clamp Techniques*
Connexins/*chemistry
Connexins/*metabolism
Nerve Tissue Proteins/*chemistry
Nerve Tissue Proteins/*metabolism
Adenosine Triphosphate/metabolism ; Animals ; Apoproteins/chemistry ; Apoproteins/metabolism ; Apoproteins/ultrastructure ; Apoptosis ; Binding Sites/drug effects ; Carbenoxolone/chemistry ; Carbenoxolone/metabolism ; Carbenoxolone/pharmacology ; Caspase 7/metabolism ; Cell Line ; Connexins/ultrastructure ; Gap Junctions ; Glycosylation ; Humans ; Models, Molecular ; Mutation ; Nerve Tissue Proteins/ultrastructure ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Sf9 Cells
Czasopismo naukowe
Tytuł :
Integrative analysis of in vivo recording with single-cell RNA-seq data reveals molecular properties of light-sensitive neurons in mouse V1.
Autorzy :
Liu J; State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Wang M; State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Sun L; State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Pan NC; State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Zhang C; State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Zhang J; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
Zuo Z; State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
He S; State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Wu Q; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China. .; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. .
Wang X; State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. .; Advanced Innovation Center for Human Brain Protection, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China. .
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Źródło :
Protein & cell [Protein Cell] 2020 Jun; Vol. 11 (6), pp. 417-432. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Light*
Patch-Clamp Techniques*
RNA-Seq*
Single-Cell Analysis*
Neurons/*metabolism
Neurons/*radiation effects
Animals ; Calcium/metabolism ; Male ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Neurons/cytology ; Nogo Receptor 1/genetics ; Nogo Receptor 1/metabolism ; RGS Proteins/genetics ; RGS Proteins/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Visual Cortex/cytology ; Visual Cortex/metabolism ; Visual Cortex/radiation effects
Czasopismo naukowe
Tytuł :
Computer modeling of whole-cell voltage-clamp analyses to delineate guidelines for good practice of manual and automated patch-clamp.
Autorzy :
Montnach, Jérôme
Lorenzini, Maxime
Lesage, Adrien
Simon, Isabelle
Nicolas, Sébastien
Moreau, Eléonore
Marionneau, Céline
Baró, Isabelle
De Waard, Michel
Loussouarn, Gildas
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Źródło :
Scientific Reports. 2/8/2021, Vol. 11 Issue 1, p1-16. 16p.
Czasopismo naukowe
Tytuł :
Mechanism of pore opening in the calcium-activated chloride channel TMEM16A.
Autorzy :
Lam AKM; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland. .
Dutzler R; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 04; Vol. 12 (1), pp. 786. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ion Channel Gating*
Models, Molecular*
Anoctamin-1/*metabolism
Calcium/*metabolism
Neoplasm Proteins/*metabolism
Allosteric Regulation ; Anoctamin-1/genetics ; Anoctamin-1/ultrastructure ; Binding Sites/genetics ; Cations, Divalent/metabolism ; Chlorides/metabolism ; HEK293 Cells ; Humans ; Kinetics ; Monte Carlo Method ; Mutation ; Neoplasm Proteins/genetics ; Neoplasm Proteins/ultrastructure ; Patch-Clamp Techniques ; Poisson Distribution ; Protein Binding/genetics ; Protein Conformation, alpha-Helical
Czasopismo naukowe
Tytuł :
Differential Synaptic Input to External Globus Pallidus Neuronal Subpopulations In Vivo.
Autorzy :
Ketzef M; Department of Neuroscience, Karolinska Institutet, Stockholm 17177, Sweden. Electronic address: .
Silberberg G; Department of Neuroscience, Karolinska Institutet, Stockholm 17177, Sweden. Electronic address: .
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Źródło :
Neuron [Neuron] 2021 Feb 03; Vol. 109 (3), pp. 516-529.e4. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Globus Pallidus/*physiology
Neurons/*physiology
Synapses/*physiology
Animals ; Mice ; Neural Pathways/physiology ; Optogenetics ; Patch-Clamp Techniques
Czasopismo naukowe
Tytuł :
Sigma-1 receptor ligands improves ventricular repolarization-related ion remodeling in rats with major depression disorder.
Autorzy :
Guo Y; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.; Cardiovascular Research Institute, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Cardiology, Wuhan, People's Republic of China.
Zhang C; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.; Cardiovascular Research Institute, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Cardiology, Wuhan, People's Republic of China.
Chen X; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.; Cardiovascular Research Institute, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Cardiology, Wuhan, People's Republic of China.
Liu X; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.; Cardiovascular Research Institute, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Cardiology, Wuhan, People's Republic of China.
Ye T; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.; Cardiovascular Research Institute, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Cardiology, Wuhan, People's Republic of China.
Fo Y; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.; Cardiovascular Research Institute, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Cardiology, Wuhan, People's Republic of China.
Shi S; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.; Cardiovascular Research Institute, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Cardiology, Wuhan, People's Republic of China.
Qu C; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.; Cardiovascular Research Institute, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Cardiology, Wuhan, People's Republic of China.
Liang J; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.; Cardiovascular Research Institute, Wuhan University, Wuhan, People's Republic of China.; Hubei Key Laboratory of Cardiology, Wuhan, People's Republic of China.
Shen B; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China. .; Cardiovascular Research Institute, Wuhan University, Wuhan, People's Republic of China. .; Hubei Key Laboratory of Cardiology, Wuhan, People's Republic of China. .
Yang B; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China. .; Cardiovascular Research Institute, Wuhan University, Wuhan, People's Republic of China. .; Hubei Key Laboratory of Cardiology, Wuhan, People's Republic of China. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2021 Feb; Vol. 238 (2), pp. 487-499. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium Channels/*metabolism
Depressive Disorder, Major/*metabolism
Heart Ventricles/*metabolism
Potassium Channels/*metabolism
Receptors, sigma/*agonists
Action Potentials/drug effects ; Animals ; Antidepressive Agents, Second-Generation/pharmacology ; Arrhythmias, Cardiac/metabolism ; Behavior, Animal/drug effects ; Disease Models, Animal ; Fluvoxamine/pharmacology ; Heart Ventricles/cytology ; Heart Ventricles/drug effects ; Ligands ; Male ; Myocardium/metabolism ; Patch-Clamp Techniques ; Rats
Czasopismo naukowe
Tytuł :
PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus.
Autorzy :
Park P; Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, Korea.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.; Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Georgiou J; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Sanderson TM; Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, Korea.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Ko KH; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, Korea.
Kang H; Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, Korea.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.; Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Kim JI; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, Korea.
Bradley CA; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, Korea.; Neurosciences and Mental Health, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Bortolotto ZA; Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.
Zhuo M; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, Korea.; Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Kaang BK; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, Korea.
Collingridge GL; Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom. .; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, Korea. .; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada. .; Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada. .; TANZ Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, M5S 1A8, Canada. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 18; Vol. 12 (1), pp. 413. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CA1 Region, Hippocampal/*physiology
Cyclic AMP-Dependent Protein Kinases/*metabolism
Excitatory Postsynaptic Potentials/*physiology
Long-Term Potentiation/*physiology
Receptors, AMPA/*metabolism
Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Male ; Memory, Long-Term/physiology ; Patch-Clamp Techniques ; Rats ; Theta Rhythm/physiology
Czasopismo naukowe
Tytuł :
L-bupivacaine Inhibition of Nociceptive Transmission in Rat Peripheral and Dorsal Horn Neurons.
Autorzy :
Uta D
Koga K
Furue H
Imoto K
Yoshimura M
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Źródło :
Anesthesiology [Anesthesiology] 2021 Jan 01; Vol. 134 (1), pp. 88-102.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anesthetics, Local/*pharmacology
Bupivacaine/*pharmacology
Neurons/*drug effects
Nociception/*drug effects
Peripheral Nerves/*drug effects
Posterior Horn Cells/*drug effects
Synaptic Transmission/*drug effects
Animals ; Excitatory Postsynaptic Potentials/drug effects ; Male ; Nerve Fibers, Myelinated/drug effects ; Nerve Fibers, Unmyelinated/drug effects ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley ; Sodium Channels/drug effects ; Stereoisomerism ; Tetrodotoxin/pharmacology
Czasopismo naukowe
Tytuł :
Toxicity and physiological actions of biflavones on potassium current in insect neuronal cells.
Autorzy :
Ren Y; Key Laboratory of Coarse Cereal Processing of Ministry of Agriculture and Rural Affairs, College of Pharmacy and Biological Engineering, Chengdu University, Chengdu, Sichuan, China; Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China.
Li Q; Key Laboratory of Coarse Cereal Processing of Ministry of Agriculture and Rural Affairs, College of Pharmacy and Biological Engineering, Chengdu University, Chengdu, Sichuan, China; Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China.
Lu L; Key Laboratory of Coarse Cereal Processing of Ministry of Agriculture and Rural Affairs, College of Pharmacy and Biological Engineering, Chengdu University, Chengdu, Sichuan, China; Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China.
Jin H; Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China.
Tao K; Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China. Electronic address: .
Hou T; Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China. Electronic address: .
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Źródło :
Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2021 Jan; Vol. 171, pp. 104735. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article
MeSH Terms :
Potassium*
Potassium Channels, Voltage-Gated*
Animals ; Insecta ; Patch-Clamp Techniques ; Potassium Channels
Czasopismo naukowe
Tytuł :
High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp.
Autorzy :
Peng Y; Institute of Neurophysiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Mittermaier FX; Institute of Neurophysiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Planert H; Institute of Neurophysiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Schneider UC; Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Alle H; Institute of Neurophysiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Geiger JRP; Institute of Neurophysiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
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Źródło :
ELife [Elife] 2019 Nov 19; Vol. 8. Date of Electronic Publication: 2019 Nov 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Patch-Clamp Techniques*
Brain/*physiology
Neurons/*physiology
Humans ; Nerve Net/physiology ; Software
Czasopismo naukowe
Tytuł :
Advances in the automation of whole-cell patch clamp technology.
Autorzy :
Suk HJ; Health Sciences and Technology, MIT, Cambridge, MA 02139, USA; Media Lab, MIT, Cambridge, MA 02139, USA; McGovern Institute, MIT, Cambridge, MA 02139, USA.
Boyden ES; Media Lab, MIT, Cambridge, MA 02139, USA; McGovern Institute, MIT, Cambridge, MA 02139, USA; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.
van Welie I; Neural Dynamics Technologies LLC, Cambridge, MA 02142, USA. Electronic address: .
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Źródło :
Journal of neuroscience methods [J Neurosci Methods] 2019 Oct 01; Vol. 326, pp. 108357. Date of Electronic Publication: 2019 Jul 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Automation, Laboratory/*methods
Electrophysiology/*methods
Neurosciences/*methods
Patch-Clamp Techniques/*methods
Animals ; Electrophysiology/trends ; Humans ; Neurosciences/trends ; Patch-Clamp Techniques/trends
Czasopismo naukowe
Tytuł :
Head-mounted approaches for targeting single-cells in freely moving animals.
Autorzy :
Valero M; New York University, NYU Neuroscience Institute, NY, USA. Electronic address: .
English DF; Virginia Tech, School of Neuroscience, VA, USA.
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Źródło :
Journal of neuroscience methods [J Neurosci Methods] 2019 Oct 01; Vol. 326, pp. 108397. Date of Electronic Publication: 2019 Aug 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Behavior, Animal*/physiology
Brain*
Electrodes*
Neurons*/physiology
Neurosciences/*methods
Patch-Clamp Techniques/*methods
Single-Cell Analysis/*methods
Animals ; Neurosciences/instrumentation ; Patch-Clamp Techniques/instrumentation ; Single-Cell Analysis/instrumentation
Czasopismo naukowe
Tytuł :
Differential effects of novel kappa opioid receptor antagonists on dopamine neurons using acute brain slice electrophysiology.
Autorzy :
Margolis EB; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States of America.
Wallace TL; BlackThorn Therapeutics, San Francisco, CA, United States of America.
Van Orden LJ; BlackThorn Therapeutics, San Francisco, CA, United States of America.
Martin WJ; BlackThorn Therapeutics, San Francisco, CA, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Dec 29; Vol. 15 (12), pp. e0232864. Date of Electronic Publication: 2020 Dec 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopaminergic Neurons/*drug effects
Membrane Potentials/*drug effects
Receptors, Opioid, kappa/*antagonists & inhibitors
Analgesics, Opioid/pharmacology ; Animals ; Benzamides/pharmacology ; Biphenyl Compounds/pharmacology ; Dopaminergic Neurons/metabolism ; Electrophysiology ; Enkephalin, D-Penicillamine (2,5)-/pharmacology ; Male ; Mesencephalon/metabolism ; Narcotic Antagonists/pharmacology ; Oxadiazoles/pharmacology ; Patch-Clamp Techniques/methods ; Piperidines/pharmacology ; Pyrrolidines/pharmacology ; Quinolines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, kappa/metabolism ; Receptors, Opioid, mu/metabolism ; Sulfonamides/pharmacology ; Ventral Tegmental Area/drug effects
Czasopismo naukowe
Tytuł :
Differential Relation between Neuronal and Behavioral Discrimination during Hippocampal Memory Encoding.
Autorzy :
Allegra M; Department of Neuroscience, Institut Pasteur, 25 Rue du Dr Roux, 75015 Paris, France.
Posani L; Department of Neuroscience, Institut Pasteur, 25 Rue du Dr Roux, 75015 Paris, France.
Gómez-Ocádiz R; Department of Neuroscience, Institut Pasteur, 25 Rue du Dr Roux, 75015 Paris, France; Sorbonne Université, Collège Doctoral, 75005 Paris, France.
Schmidt-Hieber C; Department of Neuroscience, Institut Pasteur, 25 Rue du Dr Roux, 75015 Paris, France. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Dec 23; Vol. 108 (6), pp. 1103-1112.e6. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling/*physiology
Hippocampus/*physiology
Neurons/*physiology
Spatial Memory/*physiology
Animals ; Dentate Gyrus/physiology ; Mice ; Patch-Clamp Techniques ; Photic Stimulation
Czasopismo naukowe
Tytuł :
Defying Expectations: How Neurons Compute Prediction Errors in Visual Cortex.
Autorzy :
Padamsey Z; Centre for Discovery Brain Sciences, School of Biomedical Sciences Edinburgh, Edinburgh EH8 9XD, UK.
Rochefort NL; Centre for Discovery Brain Sciences, School of Biomedical Sciences Edinburgh, Edinburgh EH8 9XD, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh EH8 9XD, UK. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Dec 23; Vol. 108 (6), pp. 1016-1019.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Visual Cortex*
Animals ; Locomotion ; Mice ; Motivation ; Neurons ; Patch-Clamp Techniques
Czasopismo naukowe
Tytuł :
Proton-dependent inhibition, inverted voltage activation, and slow gating of CLC-0 Chloride Channel.
Autorzy :
Kwon HC; Biophysics Graduate Program, University of California, Davis, California, United States of America.
Yu Y; BMCDB Graduate Program, University of California, Davis, California, United States of America.
Fairclough RH; Biophysics Graduate Program, University of California, Davis, California, United States of America.; BMCDB Graduate Program, University of California, Davis, California, United States of America.; Center for Neuroscience, University of California, Davis, California, United States of America.
Chen TY; Biophysics Graduate Program, University of California, Davis, California, United States of America.; BMCDB Graduate Program, University of California, Davis, California, United States of America.; Center for Neuroscience, University of California, Davis, California, United States of America.; Department of Neurology, University of California, Davis, California, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Dec 23; Vol. 15 (12), pp. e0240704. Date of Electronic Publication: 2020 Dec 23 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Ion Channel Gating*
Protons*
Chloride Channels/*metabolism
Chlorides/*metabolism
Chloride Channels/genetics ; Glutamic Acid/genetics ; HEK293 Cells ; Humans ; Hydrogen-Ion Concentration ; Kinetics ; Membrane Potentials ; Mutagenesis, Site-Directed ; Mutation ; Patch-Clamp Techniques ; Structural Homology, Protein
Czasopismo naukowe
Tytuł :
Opposing Influence of Top-down and Bottom-up Input on Excitatory Layer 2/3 Neurons in Mouse Primary Visual Cortex.
Autorzy :
Jordan R; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
Keller GB; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland; Faculty of Natural Sciences, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Dec 23; Vol. 108 (6), pp. 1194-1206.e5. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Motor Activity/*physiology
Neurons/*physiology
Visual Cortex/*physiology
Visual Pathways/*physiology
Animals ; Mice ; Patch-Clamp Techniques ; Photic Stimulation ; Visual Perception/physiology
Czasopismo naukowe
Tytuł :
Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel.
Autorzy :
Koster AK; Department of Chemistry, Stanford University, Stanford, CA 94305.; Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
Reese AL; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Kuryshev Y; Charles River Laboratories Cleveland, Inc., Cleveland, OH 44128.
Wen X; Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
McKiernan KA; Department of Chemistry, Stanford University, Stanford, CA 94305.
Gray EE; Department of Chemistry, Stanford University, Stanford, CA 94305.
Wu C; Charles River Laboratories Cleveland, Inc., Cleveland, OH 44128.
Huguenard JR; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305; .
Maduke M; Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305; .
Du Bois J; Department of Chemistry, Stanford University, Stanford, CA 94305; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 22; Vol. 117 (51), pp. 32711-32721. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Chloride Channels/*antagonists & inhibitors
Chloride Channels/*chemistry
Small Molecule Libraries/*chemistry
Small Molecule Libraries/*pharmacology
Animals ; Binding Sites ; CHO Cells ; Cell Line ; Chloride Channels/genetics ; Chloride Channels/metabolism ; Cricetulus ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical/methods ; Hippocampus/metabolism ; Humans ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Docking Simulation ; Organ Culture Techniques ; Patch-Clamp Techniques ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Small Molecule Libraries/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Targeting presynaptic H3 heteroreceptor in nucleus accumbens to improve anxiety and obsessive-compulsive-like behaviors.
Autorzy :
Zhang XY; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.; Institute for Brain Sciences, Nanjing University, Nanjing 210023, China.
Peng SY; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Shen LP; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Zhuang QX; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Li B; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China; .
Xie ST; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Li QX; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Shi MR; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Ma TY; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Zhang Q; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.; Institute for Brain Sciences, Nanjing University, Nanjing 210023, China.
Wang JJ; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.; Institute for Brain Sciences, Nanjing University, Nanjing 210023, China.
Zhu JN; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China; .; Institute for Brain Sciences, Nanjing University, Nanjing 210023, China.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 15; Vol. 117 (50), pp. 32155-32164. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anxiety Disorders/*drug therapy
Histamine Agonists/*administration & dosage
Nucleus Accumbens/*physiopathology
Obsessive-Compulsive Disorder/*drug therapy
Receptors, Histamine H3/*metabolism
Afferent Pathways/drug effects ; Afferent Pathways/physiopathology ; Animals ; Anxiety Disorders/etiology ; Anxiety Disorders/physiopathology ; Anxiety Disorders/psychology ; Disease Models, Animal ; Glutamates/metabolism ; Histamine/metabolism ; Histamine H3 Antagonists/administration & dosage ; Humans ; Hypothalamic Area, Lateral/drug effects ; Hypothalamic Area, Lateral/physiopathology ; Male ; Neurons/drug effects ; Neurons/metabolism ; Nucleus Accumbens/cytology ; Nucleus Accumbens/drug effects ; Obsessive-Compulsive Disorder/etiology ; Obsessive-Compulsive Disorder/physiopathology ; Obsessive-Compulsive Disorder/psychology ; Optogenetics ; Patch-Clamp Techniques ; Prefrontal Cortex/cytology ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/physiopathology ; Presynaptic Terminals/drug effects ; Presynaptic Terminals/metabolism ; Rats ; Rats, Transgenic ; Stereotaxic Techniques ; Stress, Psychological/complications ; Stress, Psychological/psychology ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
Bursting in cerebellar stellate cells induced by pharmacological agents: Non-sequential spike adding.
Autorzy :
Farjami S; Department of Physiology, McGill University, Montréal, QC, Canada.
Alexander RPD; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada.
Bowie D; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada.
Khadra A; Department of Physiology, McGill University, Montréal, QC, Canada.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Dec 14; Vol. 16 (12), pp. e1008463. Date of Electronic Publication: 2020 Dec 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
4-Aminopyridine/*pharmacology
Action Potentials/*drug effects
Cadmium/*pharmacology
Calcium Channel Blockers/*pharmacology
Cerebellum/*drug effects
Potassium Channel Blockers/*pharmacology
Purkinje Cells/*drug effects
4-Aminopyridine/administration & dosage ; Animals ; Cadmium/administration & dosage ; Cerebellum/cytology ; Cerebellum/physiology ; Dose-Response Relationship, Drug ; Mice ; Mice, Inbred C57BL ; Models, Biological ; Patch-Clamp Techniques ; Purkinje Cells/physiology
Czasopismo naukowe

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