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Tytuł :
Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.
Autorzy :
Salem RM; Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California.
Todd JN; Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts.; Center for Genomic Medicine and.
Sandholm N; Folkhälsan Research Center, Folkhälsan Institute of Genetics, Helsinki, Finland.; Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine and.
Cole JB; Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts.; Center for Genomic Medicine and.
Chen WM; Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, Virginia.
Andrews D; Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
Pezzolesi MG; Division of Nephrology and Hypertension, Diabetes and Metabolism Center, University of Utah, Salt Lake City, Utah.
McKeigue PM; Usher Institute of Population Health Sciences and Informatics and.
Hiraki LT; The Hospital for Sick Children, Toronto, Ontario, Canada.
Qiu C; Departments of Medicine and Genetics, University of Pennsylvania, Philadelphia, Pennsylvania.
Nair V; Division of Nephrology, Department of Internal Medicine and.
Di Liao C; The Hospital for Sick Children, Toronto, Ontario, Canada.
Cao JJ; The Hospital for Sick Children, Toronto, Ontario, Canada.
Valo E; Folkhälsan Research Center, Folkhälsan Institute of Genetics, Helsinki, Finland.; Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine and.
Onengut-Gumuscu S; Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, Virginia.
Smiles AM; Joslin Diabetes Center, Boston, Massachusetts.
McGurnaghan SJ; Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Haukka JK; Folkhälsan Research Center, Folkhälsan Institute of Genetics, Helsinki, Finland.; Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine and.
Harjutsalo V; Folkhälsan Research Center, Folkhälsan Institute of Genetics, Helsinki, Finland.; Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine and.; The Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
Brennan EP; Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
van Zuydam N; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Ahlqvist E; Department of Genomics, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Doyle R; Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
Ahluwalia TS; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Lajer M; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Hughes MF; Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
Park J; Departments of Medicine and Genetics, University of Pennsylvania, Philadelphia, Pennsylvania.
Skupien J; Joslin Diabetes Center, Boston, Massachusetts.
Spiliopoulou A; Usher Institute of Population Health Sciences and Informatics and.
Liu A; Department of Biostatistics and.
Menon R; Division of Nephrology, Department of Internal Medicine and.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan.
Boustany-Kari CM; Cardiometabolic Diseases Research, Boehringer Ingelheim, Ridgefield, Connecticut.
Kang HM; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan.
Nelson RG; Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona.
Klein R; University of Wisconsin-Madison, Madison, Wisconsin.
Klein BE; University of Wisconsin-Madison, Madison, Wisconsin.
Lee KE; University of Wisconsin-Madison, Madison, Wisconsin.
Gao X; The George Washington University, Washington, DC.
Mauer M; University of Minnesota, Minneapolis, Minnesota.
Maestroni S; Complications of Diabetes Unit, Division of Immunology, Transplantation and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Caramori ML; University of Minnesota, Minneapolis, Minnesota.
de Boer IH; University of Washington, Seattle, Washington.
Miller RG; University of Pittsburgh Public Health, Pittsburgh, Pennsylvania.
Guo J; University of Pittsburgh Public Health, Pittsburgh, Pennsylvania.
Boright AP; The Hospital for Sick Children, Toronto, Ontario, Canada.
Tregouet D; INSERM UMR_S 1166, Sorbonne Université, UPMC Univ Paris 06, Paris, France.; ICAN Institute for Cardiometabolism and Nutrition, Paris, France.
Gyorgy B; INSERM UMR_S 1166, Sorbonne Université, UPMC Univ Paris 06, Paris, France.; ICAN Institute for Cardiometabolism and Nutrition, Paris, France.
Snell-Bergeon JK; University of Colorado School of Medicine, Aurora, Colorado.
Maahs DM; Department of Pediatrics-Endocrinology, Stanford University, Stanford, California.
Bull SB; The Lunenfeld-Tanenbaum Research Institute, University of Toronto, Toronto, Ontario, Canada.
Canty AJ; Department of Mathematics and Statistics, McMaster University, Hamilton, Ontario, Canada.
Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Stechemesser L; First Department of Medicine, Paracelsus Medical University, Salzburg, Austria.
Paulweber B; First Department of Medicine, Paracelsus Medical University, Salzburg, Austria.
Weitgasser R; First Department of Medicine, Paracelsus Medical University, Salzburg, Austria.; Department of Medicine, Diakonissen-Wehrle Hospital, Salzburg, Austria.
Sokolovska J; University of Latvia, Riga, Latvia.
Rovīte V; Latvian Biomedical Research and Study Centre, Riga, Latvia.
Pīrāgs V; University of Latvia, Riga, Latvia.; Pauls Stradins University Hospital, Riga, Latvia.
Prakapiene E; Medical Academy and.
Radzeviciene L; Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Verkauskiene R; Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Panduru NM; Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; 2nd Clinical Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Groop LC; Department of Genomics, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.; Genentech, 1 DNA Way, South San Francisco, California.
Gu HF; Department of Clinical Science, Intervention and Technology and.; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Möllsten A; Division of Pediatrics, Department of Clinical Sciences, Umeå University, Umeå, Sweden.
Falhammar H; Department of Molecular Medicine and Surgery, Rolf Luft Center for Diabetes Research and Endocrinology, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology, Diabetes and Metabolism, Karolinska University Hospital, Stockholm, Sweden.
Brismar K; Department of Molecular Medicine and Surgery, Rolf Luft Center for Diabetes Research and Endocrinology, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology, Diabetes and Metabolism, Karolinska University Hospital, Stockholm, Sweden.
Martin F; Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
Rossing P; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; University of Copenhagen, Copenhagen, Denmark.
Costacou T; University of Pittsburgh Public Health, Pittsburgh, Pennsylvania.
Zerbini G; Complications of Diabetes Unit, Division of Immunology, Transplantation and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Marre M; Department of Diabetology, Endocrinology and Nutrition, Bichat Hospital, DHU FIRE, Assistance Publique-Hôpitaux de Paris, Paris, France.; UFR de Médecine, Paris Diderot University, Sorbonne Paris Cité, Paris, France.; INSERM UMRS 1138, Cordeliers Research Center, Paris, France.; Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
Hadjadj S; Department of Endocrinology and Diabetology, Centre Hospitalier Universitaire de Poitiers, Poitiers, France.; INSERM CIC 1402, Poitiers, France.; L'institut du thorax, INSERM, CNRS, CHU Nantes, Nantes, France.
McKnight AJ; Centre for Public Health, Queens University of Belfast, Northern Ireland, UK.
Forsblom C; Folkhälsan Research Center, Folkhälsan Institute of Genetics, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine and.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine and.
McKay G; Centre for Public Health, Queens University of Belfast, Northern Ireland, UK.
Godson C; Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
Maxwell AP; Centre for Public Health, Queens University of Belfast, Northern Ireland, UK.
Kretzler M; Division of Nephrology, Department of Internal Medicine and.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan.
Susztak K; Departments of Medicine and Genetics, University of Pennsylvania, Philadelphia, Pennsylvania.
Colhoun HM; Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Krolewski A; Joslin Diabetes Center, Boston, Massachusetts.
Paterson AD; The Hospital for Sick Children, Toronto, Ontario, Canada.
Groop PH; Folkhälsan Research Center, Folkhälsan Institute of Genetics, Helsinki, Finland.; Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine and.; Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia; and.
Rich SS; Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, Virginia.
Hirschhorn JN; Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts.
Florez JC; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts; .; Center for Genomic Medicine and.; Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts.
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Corporate Authors :
SUMMIT Consortium, DCCT/EDIC Research Group, GENIE Consortium
Źródło :
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2019 Oct; Vol. 30 (10), pp. 2000-2016. Date of Electronic Publication: 2019 Sep 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome-Wide Association Study*
Glomerular Basement Membrane*
Mutation*
Autoantigens/*genetics
Collagen Type IV/*genetics
Diabetes Mellitus, Type 1/*genetics
Diabetic Nephropathies/*genetics
Cohort Studies ; Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
Fast and Accurate Shared Segment Detection and Relatedness Estimation in Un-phased Genetic Data via TRUFFLE.
Autorzy :
Dimitromanolakis A; Department of Statistical Sciences, University of Toronto, Toronto, ON M5S 3G3, Canada; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Toronto, ON MT5 3L9, Canada.
Paterson AD; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, ON M5T 3M7, Canada; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, ON M5T 3M7, Canada. Electronic address: andrew.paterson@sickkids.ca.
Sun L; Department of Statistical Sciences, University of Toronto, Toronto, ON M5S 3G3, Canada; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, ON M5T 3M7, Canada. Electronic address: .
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Źródło :
American journal of human genetics [Am J Hum Genet] 2019 Jul 03; Vol. 105 (1), pp. 78-88. Date of Electronic Publication: 2019 Jun 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Predisposition to Disease*
Genetics, Population*
Polymorphism, Single Nucleotide*
Quantitative Trait, Heritable*
Software*
Chromosome Mapping/*methods
Genome-Wide Association Study/*methods
Algorithms ; Computer Simulation ; Female ; Genetic Linkage ; Genome, Human ; Genomics ; Germ-Line Mutation ; Haplotypes ; Humans ; Male ; Models, Genetic ; Pedigree
Czasopismo naukowe
Tytuł :
Genetic Determinants of Glycated Hemoglobin in Type 1 Diabetes.
Autorzy :
Syreeni A; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Sandholm N; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Cao J; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Toppila I; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Maahs DM; Division of Endocrinology and Diabetes, Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA.
Rewers MJ; Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO.
Snell-Bergeon JK; Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO.
Costacou T; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Orchard TJ; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Caramori ML; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, MN.
Mauer M; Departments of Pediatrics and Medicine, University of Minnesota, Minneapolis, MN.
Klein BEK; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI.
Klein R; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI.
Valo E; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Parkkonen M; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Forsblom C; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Harjutsalo V; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
Paterson AD; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Groop PH
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Corporate Authors :
DCCT/EDIC Research Group
FinnDiane Study Group
Źródło :
Diabetes [Diabetes] 2019 Apr; Vol. 68 (4), pp. 858-867. Date of Electronic Publication: 2019 Jan 23.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 1/*genetics
Genome-Wide Association Study/*methods
Glycated Hemoglobin A/*genetics
Blood Glucose/metabolism ; Diabetes Complications/genetics ; Diabetes Complications/metabolism ; Diabetes Mellitus, Type 1/metabolism ; Female ; Glycated Hemoglobin A/metabolism ; Humans ; Male
Czasopismo naukowe
Tytuł :
Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.
Autorzy :
Pollack S; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Igo RP Jr; Department of Population and Quantitative Health Sciences, Case Western University, Cleveland, OH.
Jensen RA; Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA.
Christiansen M; Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA.
Li X; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Cheng CY; Duke-NUS Medical School, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Ng MCY; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC.
Smith AV; Department of Medicine, University of Iceland, Reykjavík, Iceland.
Rossin EJ; Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA.
Segrè AV; Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA.
Davoudi S; Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA.
Tan GS; Duke-NUS Medical School, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Chen YI; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Kuo JZ; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.; Medical Affairs, Ophthalmology, Sun Pharmaceutical Industries, Inc., Princeton, NJ.
Dimitrov LM; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC.
Stanwyck LK; Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA.
Meng W; Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee School of Medicine, Scotland, U.K.
Hosseini SM; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Imamura M; Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.; Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara, Japan.
Nousome D; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Kim J; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Hai Y; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Jia Y; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Ahn J; Department of Ophthalmology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
Leong A; Endocrine Unit and Diabetes Unit, Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA.
Shah K; Section of Genetic Medicine, University of Chicago, Chicago, IL.
Park KH; Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Guo X; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Ipp E; Section of Diabetes and Metabolism, Harbor-UCLA Medical Center, University of California, Los Angeles, Los Angeles, CA.
Taylor KD; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Adler SG; Department of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor-University of California, Torrance, CA.
Sedor JR; Department of Medicine, Case Western Reserve University, Cleveland, OH.; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.; Division of Nephrology, MetroHealth System, Cleveland, OH.
Freedman BI; Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
Lee IT; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Sheu WH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Takahashi A; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Osaka, Japan.
Hadjadj S; CHU de Poitiers, Centre d'Investigation Clinique, Poitiers, France.; Université de Poitiers, UFR Médecine Pharmacie, Centre d'Investigation Clinique 1402, Poitiers, France.; INSERM, Centre d'Investigation Clinique 1402, Poitiers, France.; L'Institut du Thorax, INSERM, CNRS, CHU Nantes, Nantes, France.
Marre M; Université Paris Diderot, Sorbonne Paris Cité, Paris, France.; Department of Diabetology, Endocrinology and Nutrition, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, DHU FIRE, Paris, France.; INSERM U1138, Centre de Recherche des Cordeliers, Paris, France.
Tregouet DA; Team Genomics & Pathophysiology of Cardiovascular Diseases, UPMC, Sorbonne Universités, INSERM, UMR_S 1166, Paris, France.; Institute of Cardiometabolism and Nutrition, Paris, France.
Mckean-Cowdin R; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA.
Varma R; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA.
McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, U.K.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, U.K.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, U.K.
Groop L; Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.
Ahlqvist E; Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.
Lyssenko V; Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.; Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway.
Agardh E; Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.
Morris A; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, U.K.
Doney ASF; Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, U.K.
Colhoun HM; Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, U.K.
Toppila I; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Sandholm N; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Groop PH; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.; Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Maeda S; Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.; Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara, Japan.
Hanis CL; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Penman A; Department of Preventive Medicine, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS.
Chen CJ; Department of Ophthalmology, University of Mississippi Medical Center, Jackson, MS.
Hancock H; Department of Ophthalmology, University of Mississippi Medical Center, Jackson, MS.
Mitchell P; Centre for Vision Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Craig JE; Department of Ophthalmology, Flinders University, Bedford Park, South Australia, Australia.
Chew EY; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD.
Paterson AD; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.; Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada.; Epidemiology and Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Grassi MA; Grassi Retina, Naperville, IL.; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL.
Palmer C; Pat MacPherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, U.K.
Bowden DW; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC.
Yaspan BL; Genentech, Inc., South San Francisco, CA.
Siscovick D; Institute for Urban Health, New York Academy of Medicine, New York, NY.
Cotch MF; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD.
Wang JJ; Duke-NUS Medical School, Singapore.; Centre for Vision Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Burdon KP; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Wong TY; Duke-NUS Medical School, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Klein BEK; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI.
Klein R; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI.
Rotter JI; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Iyengar SK; Department of Population and Quantitative Health Sciences, Case Western University, Cleveland, OH.
Price AL; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Sobrin L; Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA .
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Corporate Authors :
Family Investigation of Nephropathy and Diabetes-Eye Research Group, DCCT/EDIC Research Group
Źródło :
Diabetes [Diabetes] 2019 Feb; Vol. 68 (2), pp. 441-456. Date of Electronic Publication: 2018 Nov 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2/*genetics
Genome-Wide Association Study/*methods
Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Diabetic Retinopathy ; Genetic Predisposition to Disease ; Genotype ; Glycated Hemoglobin A/metabolism ; Humans ; Meta-Analysis as Topic ; Polymorphism, Single Nucleotide/genetics ; Protein Binding
Czasopismo naukowe
Tytuł :
Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes.
Autorzy :
Roshandel D; Genetics and Genome Biology Program, Peter Gilgan Centre for Research and Learning (PGCRL), The Hospital for Sick Children, 686 Bay Street, Toronto, ON, M5G 1H3, Canada.
Gubitosi-Klug R; University Hospitals Case Western Medical Center, Cleveland, OH, USA.
Bull SB; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Canty AJ; Department of Mathematics and Statistics, McMaster University, Hamilton, ON, Canada.
Pezzolesi MG; Division of Nephrology and Hypertension, Diabetes and Metabolism Center, University of Utah, Salt Lake City, UT, USA.
King GL; Research Division, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Keenan HA; Research Division, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Snell-Bergeon JK; Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Maahs DM; Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Department of Paediatrics, Stanford School of Medicine, Stanford, CA, USA.
Klein R; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA.
Klein BEK; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA.
Orchard TJ; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Costacou T; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Weedon MN; Institute for Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Oram RA; Institute for Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.; National Institute for Health Research, Exeter Clinical Research Facility, Exeter, UK.
Paterson AD; Genetics and Genome Biology Program, Peter Gilgan Centre for Research and Learning (PGCRL), The Hospital for Sick Children, 686 Bay Street, Toronto, ON, M5G 1H3, Canada. andrew.paterson@sickkids.ca.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. andrew.paterson@sickkids.ca.
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Corporate Authors :
DCCT/EDIC Research Group
Źródło :
Diabetologia [Diabetologia] 2018 May; Vol. 61 (5), pp. 1098-1111. Date of Electronic Publication: 2018 Feb 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome-Wide Association Study*
C-Peptide/*blood
Chromosomes, Human, Pair 1/*genetics
Diabetes Mellitus, Type 1/*genetics
Histocompatibility Antigens Class I/*genetics
Adolescent ; Adult ; Alleles ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/blood ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Insulin-Secreting Cells/metabolism ; Male ; Polymorphism, Single Nucleotide ; Young Adult
Czasopismo naukowe
Tytuł :
Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.
Autorzy :
Fan Q; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.; Duke-NUS Medical School, Singapore 169857, Singapore.
Verhoeven VJ; Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Wojciechowski R; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 20205, USA.
Barathi VA; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.; Duke-NUS Medical School, Singapore 169857, Singapore.; Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore.
Hysi PG; Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, London SE1 7EH, UK.
Guggenheim JA; School of Optometry and Vision Sciences, Cardiff University, Cardiff CF24 4HQ, UK.
Höhn R; Department of Ophthalmology, University Medical Center Mainz, 55131 Mainz, Germany.; Department of Ophthalmology, Inselspital, University Hospital Bern, CH-3010 Bern, Switzerland.
Vitart V; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland.
Khawaja AP; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge CB2 0SR, UK.
Yamashiro K; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
Hosseini SM; Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto, Toronto Ontario, Canada M5G 1X8.
Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere 33520, Finland.
Lu Y; Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland 4029, Australia.
Haller T; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Xie J; Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria 3002, Australia.
Delcourt C; Université de Bordeaux, ISPED (Institut de Santé Publique d'Épidémiologie et de Développement), Bordeaux 33000, France.; INSERM, U1219-Bordeaux Population Health Research Center, Bordeaux 33000, France.
Pirastu M; Institute of Population Genetics, National Research Council, Sassari 07100, Italy.
Wedenoja J; Department of Public Health, University of Helsinki, Helsinki 00014, Finland.; Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland.
Gharahkhani P; Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland 4029, Australia.
Venturini C; Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, London SE1 7EH, UK.; UCL Institute of Ophthalmology, London SE1 7EH, UK.
Miyake M; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
Hewitt AW; Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria 3002, Australia.; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania 7000, Australia.
Guo X; Department of Statistical Science, School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, China.
Mazur J; Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, 55131 Mainz, Germany.
Huffman JE; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland.
Williams KM; Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, London SE1 7EH, UK.; Department of Ophthalmology, King's College London, London SE1 7EH, UK.
Polasek O; Faculty of Medicine, University of Split, Split 21000, Croatia.
Campbell H; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland.
Rudan I; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland.
Vatavuk Z; Department of Ophthalmology, Sisters of Mercy University Hospital, Zagreb 10000, Croatia.
Wilson JF; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland.
Joshi PK; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland.
McMahon G; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol BS8 2BN, UK.; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
St Pourcain B; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol BS8 2BN, UK.; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.; Max Planck Institute for Psycholinguistics, Wundtlaan 1, 6525 XD Nijmegen, The Netherlands.
Evans DM; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol BS8 2BN, UK.; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia.
Simpson CL; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA.; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
Schwantes-An TH; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA.
Igo RP; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Mirshahi A; Department of Ophthalmology, University Medical Center Mainz, 55131 Mainz, Germany.; Dardenne Eye Hospital, Bonn-Bad Godesberg, 53177 Bonn, Germany.
Cougnard-Gregoire A; Université de Bordeaux, ISPED (Institut de Santé Publique d'Épidémiologie et de Développement), Bordeaux 33000, France.; INSERM, U1219-Bordeaux Population Health Research Center, Bordeaux 33000, France.
Bellenguez C; Inserm, U1167, Lille 59000, France.; Univ. Lille, U1167, Lille 59000, France.; Université Lille 2, Lille 59000, France.
Blettner M; Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, 55131 Mainz, Germany.
Raitakari O; Research Centre of Applied and Preventive Medicine, University of Turku, Turku 20520, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20520, Finland.
Kähönen M; Department of Clinical Physiology, Tampere University Hospital and School of Medicine, University of Tampere, Tampere 33520, Finland.
Seppala I; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere 33520, Finland.
Zeller T; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.
Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.; Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Portas L; Institute of Population Genetics, National Research Council, Sassari 07100, Italy.
van Leeuwen EM; Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Amin N; Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, 2518 AD Hague, The Netherlands.
Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, 2518 AD Hague, The Netherlands.
Hofman A; Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, 2518 AD Hague, The Netherlands.
Vingerling JR; Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Wang YX; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100044, China.
Wang X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems, Singapore 117549, Singapore.
Tai-Hui Boh E; Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems, Singapore 117549, Singapore.
Ikram MK; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.; Duke-NUS Medical School, Singapore 169857, Singapore.
Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.; Duke-NUS Medical School, Singapore 169857, Singapore.
Gupta P; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Tan V; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Zhou L; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Ho CE; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Lim W; Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore.
Beuerman RW; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.; Duke-NUS Medical School, Singapore 169857, Singapore.; Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore.
Siantar R; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore 308433, Singapore.
Tai ES; Duke-NUS Medical School, Singapore 169857, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems, Singapore 117549, Singapore.; Department of Medicine, National University of Singapore, Singapore 119228, Singapore.
Vithana E; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.; Duke-NUS Medical School, Singapore 169857, Singapore.; Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore.
Mihailov E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Khor CC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems, Singapore 117549, Singapore.; Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland.
Luben RN; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge CB2 0SR, UK.
Foster PJ; Division of Genetics and Epidemiology, UCL Institute of Ophthalmology, London EC1V 9EL, UK.; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London EC1V 2PD, UK.
Klein BE; Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA.
Klein R; Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA.
Wong HS; Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto, Toronto Ontario, Canada M5G 1X8.
Mitchell P; Department of Ophthalmology, Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales 2145, Australia.
Metspalu A; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.; Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore.
Young TL; Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53705, USA.
He M; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China.
Pärssinen O; Department of Ophthalmology, Central Hospital of Central Finland, Jyväskylä 40620, Finland.; Gerontology Research Center and Department of Health Sciences, University of Jyväskylä, Jyväskylä 40014, Finland.
van Duijn CM; Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Jin Wang J; Department of Ophthalmology, Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales 2145, Australia.
Williams C; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Jonas JB; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100044, China.; Medical Faculty Mannheim, Department of Ophthalmology, Ruprecht-Karls-University Heidelberg, 69115 Mannheim, Germany.
Teo YY; Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems, Singapore 117549, Singapore.; Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore 117546, Singapore.
Mackey DA; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania 7000, Australia.; Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia 6009, Australia.
Oexle K; Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
Yoshimura N; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
Paterson AD; Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto, Toronto Ontario, Canada M5G 1X8.
Pfeiffer N; Department of Ophthalmology, University Medical Center Mainz, 55131 Mainz, Germany.
Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.; Duke-NUS Medical School, Singapore 169857, Singapore.; Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems, Singapore 117549, Singapore.
Baird PN; Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria 3002, Australia.
Stambolian D; Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Wilson JE; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA.
Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.; Duke-NUS Medical School, Singapore 169857, Singapore.; Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore.
Hammond CJ; Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, London SE1 7EH, UK.; Department of Ophthalmology, King's College London, London SE1 7EH, UK.
Klaver CC; Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Saw SM; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.; Duke-NUS Medical School, Singapore 169857, Singapore.; Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems, Singapore 117549, Singapore.
Rahi JS
Korobelnik JF
Kemp JP
Timpson NJ
Smith GD
Craig JE
Burdon KP
Fogarty RD
Iyengar SK
Chew E
Janmahasatian S
Martin NG
MacGregor S; Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland 4029, Australia.
Xu L; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100044, China.
Schache M; Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria 3002, Australia.
Nangia V
Panda-Jonas S
Wright AF; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland.
Fondran JR
Lass JH
Feng S
Zhao JH
Khaw KT; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge CB2 0SR, UK.
Wareham NJ
Rantanen T
Kaprio J
Pang CP
Chen LJ
Tam PO
Jhanji V
Young AL
Döring A
Raffel LJ
Cotch MF
Li X
Yip SP
Yap MK
Biino G
Vaccargiu S; Institute of Population Genetics, National Research Council, Sassari 07100, Italy.
Fossarello M; Institute of Population Genetics, National Research Council, Sassari 07100, Italy.
Fleck B
Yazar S; Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria 3002, Australia.; Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia 6009, Australia.
Tideman JW; Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Tedja M; Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Deangelis MM
Morrison M
Farrer L
Zhou X
Chen W
Mizuki N
Meguro A
Mäkelä KM
Pokaż więcej
Corporate Authors :
Consortium for Refractive Error and Myopia
Źródło :
Nature communications [Nat Commun] 2016 Mar 29; Vol. 7, pp. 11008. Date of Electronic Publication: 2016 Mar 29.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
Educational Status*
Environment*
Genetic Loci*
Genetic Predisposition to Disease*
Genome-Wide Association Study*
Refractive Errors/*genetics
Asian Continental Ancestry Group/genetics ; European Continental Ancestry Group/genetics ; Gene Expression Profiling ; Humans ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Tytuł :
Resampling to Address the Winner's Curse in Genetic Association Analysis of Time to Event.
Autorzy :
Poirier JG; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.
Faye LL; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Dimitromanolakis A; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.
Paterson AD; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.; Hospital for Sick Children Research Institute, Toronto, Canada.
Sun L; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.; Department of Statistical Sciences, University of Toronto, Toronto, Canada.
Bull SB; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Pokaż więcej
Źródło :
Genetic epidemiology [Genet Epidemiol] 2015 Nov; Vol. 39 (7), pp. 518-28. Date of Electronic Publication: 2015 Sep 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome-Wide Association Study/*methods
Bias ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/therapy ; False Positive Reactions ; Female ; Genotype ; Humans ; Kidney Diseases/complications ; Kidney Diseases/genetics ; Kidney Diseases/pathology ; Male ; Models, Genetic ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Proportional Hazards Models ; Risk ; Sample Size ; Time Factors
Czasopismo naukowe
Tytuł :
Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.
Autorzy :
Li Q; National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive Suite 1200, Baltimore, MD, 21224, USA.
Wojciechowski R
Simpson CL
Hysi PG
Verhoeven VJ
Ikram MK
Höhn R
Vitart V
Hewitt AW
Oexle K
Mäkelä KM
MacGregor S
Pirastu M
Fan Q
Cheng CY
St Pourcain B
McMahon G
Kemp JP
Northstone K
Rahi JS
Cumberland PM
Martin NG
Sanfilippo PG
Lu Y
Wang YX
Hayward C
Polašek O
Campbell H
Bencic G
Wright AF
Wedenoja J
Zeller T
Schillert A
Mirshahi A
Lackner K
Yip SP
Yap MK
Ried JS
Gieger C
Murgia F
Wilson JF
Fleck B
Yazar S
Vingerling JR
Hofman A
Uitterlinden A
Rivadeneira F
Amin N
Karssen L
Oostra BA
Zhou X
Teo YY
Tai ES
Vithana E
Barathi V
Zheng Y
Siantar RG
Neelam K
Shin Y
Lam J
Yonova-Doing E
Venturini C
Hosseini SM
Wong HS
Lehtimäki T
Kähönen M
Raitakari O
Timpson NJ
Evans DM
Khor CC
Aung T
Young TL
Mitchell P
Klein B
van Duijn CM
Meitinger T
Jonas JB
Baird PN
Mackey DA
Wong TY
Saw SM
Pärssinen O
Stambolian D
Hammond CJ
Klaver CC
Williams C
Paterson AD
Bailey-Wilson JE
Guggenheim JA
Pokaż więcej
Corporate Authors :
CREAM Consortium
Źródło :
Human genetics [Hum Genet] 2015 Feb; Vol. 134 (2), pp. 131-46. Date of Electronic Publication: 2014 Nov 04.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
Genome-Wide Association Study*
Astigmatism/*genetics
Cell Adhesion Molecules, Neuronal/*genetics
High Mobility Group Proteins/*genetics
Nerve Tissue Proteins/*genetics
Adult ; Age Factors ; Asian Continental Ancestry Group ; Astigmatism/pathology ; Calcium-Binding Proteins ; Cohort Studies ; European Continental Ancestry Group ; Female ; Genetic Markers ; Humans ; Male ; Middle Aged ; Neural Cell Adhesion Molecules
Czasopismo naukowe
Tytuł :
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
Autorzy :
Lindström S; 1] Program in Genetic Epidemiology and Statistical Genetics, Harvard School Of Public Health, Boston, Massachusetts 02115, USA [2] Department of Epidemiology, Harvard School Of Public Health, Boston, Massachusetts 02115, USA.
Thompson DJ; 1] Centre for Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK [2] Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Paterson AD; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.
Li J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Gierach GL; Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20850, USA.
Scott C; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Stone J; Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, Western Australia 6009, Australia.
Douglas JA; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
dos-Santos-Silva I; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Fernandez-Navarro P; 1] Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid 28029, Spain [2] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid 28029, Spain.
Verghase J; 1] Centre for Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK [2] Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK [3] Plastic Surgery Unit, Royal Free Hospital, London NW3 2QG, UK.
Smith P; 1] Centre for Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK [2] Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Brown J; 1] Centre for Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK [2] Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Luben R; Centre for Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Wareham NJ; Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB1 8RN, UK.
Loos RJ; 1] Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB1 8RN, UK [2] The Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, New York, New York 10029, USA.
Heit JA; Division of Cardiovascular Disease, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Pankratz VS; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Norman A; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Goode EL; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Cunningham JM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
deAndrade M; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Vierkant RA; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Czene K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Fasching PA; 1] Department of Gynecology and Obstetrics, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 910 54 Erlangen, Germany [2] Division Hematology/Oncology, Department of Medicine, University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, California 90024, USA.
Baglietto L; 1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Southey MC; Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia.
Giles GG; 1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Shah KP; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Chan HP; Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Helvie MA; Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Beck AH; Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA.
Knoblauch NW; Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA.
Hazra A; 1] Program in Genetic Epidemiology and Statistical Genetics, Harvard School Of Public Health, Boston, Massachusetts 02115, USA [2] Department of Epidemiology, Harvard School Of Public Health, Boston, Massachusetts 02115, USA [3] Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Hunter DJ; 1] Program in Genetic Epidemiology and Statistical Genetics, Harvard School Of Public Health, Boston, Massachusetts 02115, USA [2] Department of Epidemiology, Harvard School Of Public Health, Boston, Massachusetts 02115, USA [3] Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Kraft P; 1] Program in Genetic Epidemiology and Statistical Genetics, Harvard School Of Public Health, Boston, Massachusetts 02115, USA [2] Department of Epidemiology, Harvard School Of Public Health, Boston, Massachusetts 02115, USA [3] Department of Biostatistics, Harvard School Of Public Health, Boston, Massachusetts 02115, USA.
Pollan M; 1] Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid 28029, Spain [2] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid 28029, Spain.
Figueroa JD; Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20850, USA.
Couch FJ; 1] Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA [2] Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Easton DF; 1] Centre for Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK [2] Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK [3] Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Boyd NF; Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada M5G 2M9.
Vachon CM; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Tamimi RM; 1] Program in Genetic Epidemiology and Statistical Genetics, Harvard School Of Public Health, Boston, Massachusetts 02115, USA [2] Department of Epidemiology, Harvard School Of Public Health, Boston, Massachusetts 02115, USA [3] Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2014 Oct 24; Vol. 5, pp. 5303. Date of Electronic Publication: 2014 Oct 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genetic Loci*
Genetic Predisposition to Disease*
Genome-Wide Association Study*
Breast Neoplasms/*diagnostic imaging
Breast Neoplasms/*genetics
Mammary Glands, Human/*abnormalities
Breast Density ; Case-Control Studies ; Female ; Humans ; Polymorphism, Single Nucleotide/genetics ; Radiography
Czasopismo naukowe
Tytuł :
Drinking from the Holy Grail: analysis of whole-genome sequencing from the Genetic Analysis Workshop 18.
Autorzy :
Paterson AD; Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada; Divisions of Epidemiology and Biostatistics, Dalla Lana School of Public Health, Department of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.
Pokaż więcej
Źródło :
Genetic epidemiology [Genet Epidemiol] 2014 Sep; Vol. 38 Suppl 1, pp. S1-4.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Education*
Genome-Wide Association Study*
Blood Pressure/genetics ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/pathology ; Genetics, Population ; Genotype ; High-Throughput Nucleotide Sequencing ; Humans ; Linkage Disequilibrium ; Pedigree ; Phenotype ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes.
Autorzy :
Sandholm N; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland.
Forsblom C
Mäkinen VP
McKnight AJ
Osterholm AM
He B
Harjutsalo V
Lithovius R
Gordin D
Parkkonen M
Saraheimo M
Thorn LM
Tolonen N
Wadén J
Tuomilehto J
Lajer M
Ahlqvist E
Möllsten A
Marcovecchio ML
Cooper J
Dunger D
Paterson AD
Zerbini G
Groop L
Tarnow L
Maxwell AP
Tryggvason K
Groop PH
Pokaż więcej
Corporate Authors :
SUMMIT Consortium
FinnDiane Study Group
Źródło :
Diabetologia [Diabetologia] 2014 Jun; Vol. 57 (6), pp. 1143-53. Date of Electronic Publication: 2014 Mar 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Albuminuria/*genetics
Diabetes Mellitus, Type 1/*urine
Genome-Wide Association Study/*methods
Adult ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Tytuł :
Letter to the editor: expression of concern, reaffirmed.
Autorzy :
Paterson AD; Program in Genetics and Genome Biology, The Hospital for Sick Children, TMDT East Tower, Room 15-707, 101 College Street, Toronto, ON, M5G 1L7, Canada, andrew.paterson@utoronto.ca.
Pokaż więcej
Źródło :
Age (Dordrecht, Netherlands) [Age (Dordr)] 2014 Feb; Vol. 36 (1), pp. 479-82. Date of Electronic Publication: 2013 Aug 24.
Typ publikacji :
Letter; Comment
MeSH Terms :
Genome-Wide Association Study*
Genomics*
Phenotype*
Polymorphism, Single Nucleotide*
Aging/*genetics
Longevity/*genetics
Female ; Humans ; Male ; Pregnancy
Opinia redakcyjna
Tytuł :
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
Autorzy :
Lee SH
Ripke S
Neale BM
Faraone SV
Purcell SM
Perlis RH
Mowry BJ
Thapar A
Goddard ME
Witte JS
Absher D
Agartz I
Akil H
Amin F
Andreassen OA
Anjorin A
Anney R
Anttila V
Arking DE
Asherson P
Azevedo MH
Backlund L
Badner JA
Bailey AJ
Banaschewski T
Barchas JD
Barnes MR
Barrett TB
Bass N
Battaglia A
Bauer M
Bayés M
Bellivier F
Bergen SE
Berrettini W
Betancur C
Bettecken T
Biederman J
Binder EB
Black DW
Blackwood DH
Bloss CS
Boehnke M
Boomsma DI
Breen G
Breuer R
Bruggeman R
Cormican P
Buccola NG
Buitelaar JK
Bunney WE
Buxbaum JD
Byerley WF
Byrne EM
Caesar S
Cahn W
Cantor RM
Casas M
Chakravarti A
Chambert K
Choudhury K
Cichon S
Cloninger CR
Collier DA
Cook EH
Coon H
Cormand B
Corvin A
Coryell WH
Craig DW
Craig IW
Crosbie J
Cuccaro ML
Curtis D
Czamara D
Datta S
Dawson G
Day R
De Geus EJ
Degenhardt F
Djurovic S
Donohoe GJ
Doyle AE
Duan J
Dudbridge F
Duketis E
Ebstein RP
Edenberg HJ
Elia J
Ennis S
Etain B
Fanous A
Farmer AE
Ferrier IN
Flickinger M
Fombonne E
Foroud T
Frank J
Franke B
Fraser C
Freedman R
Freimer NB
Freitag CM
Friedl M
Frisén L
Gallagher L
Gejman PV
Georgieva L
Gershon ES
Geschwind DH
Giegling I
Gill M
Gordon SD
Gordon-Smith K
Green EK
Greenwood TA
Grice DE
Gross M
Grozeva D
Guan W
Gurling H
De Haan L
Haines JL
Hakonarson H
Hallmayer J
Hamilton SP
Hamshere ML
Hansen TF
Hartmann AM
Hautzinger M
Heath AC
Henders AK
Herms S
Hickie IB
Hipolito M
Hoefels S
Holmans PA
Holsboer F
Hoogendijk WJ
Hottenga JJ
Hultman CM
Hus V
Ingason A
Ising M
Jamain S
Jones EG
Jones I
Jones L
Tzeng JY
Kähler AK
Kahn RS
Kandaswamy R
Keller MC
Kennedy JL
Kenny E
Kent L
Kim Y
Kirov GK
Klauck SM
Klei L
Knowles JA
Kohli MA
Koller DL
Konte B
Korszun A
Krabbendam L
Krasucki R
Kuntsi J
Kwan P
Landén M
Långström N
Lathrop M
Lawrence J
Lawson WB
Leboyer M
Ledbetter DH
Lee PH
Lencz T
Lesch KP
Levinson DF
Lewis CM
Li J
Lichtenstein P
Lieberman JA
Lin DY
Linszen DH
Liu C
Lohoff FW
Loo SK
Lord C
Lowe JK
Lucae S
MacIntyre DJ
Madden PA
Maestrini E
Magnusson PK
Mahon PB
Maier W
Malhotra AK
Mane SM
Martin CL
Martin NG
Mattheisen M
Matthews K
Mattingsdal M
McCarroll SA
McGhee KA
McGough JJ
McGrath PJ
McGuffin P
McInnis MG
McIntosh A
McKinney R
McLean AW
McMahon FJ
McMahon WM
McQuillin A
Medeiros H
Medland SE
Meier S
Melle I
Meng F
Meyer J
Middeldorp CM
Middleton L
Milanova V
Miranda A
Monaco AP
Montgomery GW
Moran JL
Moreno-De-Luca D
Morken G
Morris DW
Morrow EM
Moskvina V
Muglia P
Mühleisen TW
Muir WJ
Müller-Myhsok B
Murtha M
Myers RM
Myin-Germeys I
Neale MC
Nelson SF
Nievergelt CM
Nikolov I
Nimgaonkar V
Nolen WA
Nöthen MM
Nurnberger JI
Nwulia EA
Nyholt DR
O'Dushlaine C
Oades RD
Olincy A
Oliveira G
Olsen L
Ophoff RA
Osby U
Owen MJ
Palotie A
Parr JR
Paterson AD
Pato CN
Pato MT
Penninx BW
Pergadia ML
Pericak-Vance MA
Pickard BS
Pimm J
Piven J
Posthuma D
Potash JB
Poustka F
Propping P
Puri V
Quested DJ
Quinn EM
Ramos-Quiroga JA
Rasmussen HB
Raychaudhuri S
Rehnström K
Reif A
Ribasés M
Rice JP
Rietschel M
Roeder K
Roeyers H
Rossin L
Rothenberger A
Rouleau G
Ruderfer D
Rujescu D
Sanders AR
Sanders SJ
Santangelo SL
Sergeant JA
Schachar R
Schalling M
Schatzberg AF
Scheftner WA
Schellenberg GD
Scherer SW
Schork NJ
Schulze TG
Schumacher J
Schwarz M
Scolnick E
Scott LJ
Shi J
Shilling PD
Shyn SI
Silverman JM
Slager SL
Smalley SL
Smit JH
Smith EN
Sonuga-Barke EJ
St Clair D
State M
Steffens M
Steinhausen HC
Strauss JS
Strohmaier J
Stroup TS
Sutcliffe JS
Szatmari P
Szelinger S
Thirumalai S
Thompson RC
Todorov AA
Tozzi F
Treutlein J
Uhr M
van den Oord EJ
Van Grootheest G
Van Os J
Vicente AM
Vieland VJ
Vincent JB
Visscher PM
Walsh CA
Wassink TH
Watson SJ
Weissman MM
Werge T
Wienker TF
Wijsman EM
Willemsen G
Williams N
Willsey AJ
Witt SH
Xu W
Young AH
Yu TW
Zammit S
Zandi PP
Zhang P
Zitman FG
Zöllner S
Devlin B
Kelsoe JR
Sklar P
Daly MJ
O'Donovan MC
Craddock N
Sullivan PF
Smoller JW
Kendler KS
Wray NR
Pokaż więcej
Corporate Authors :
Cross-Disorder Group of the Psychiatric Genomics Consortium; The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia.
International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)
Źródło :
Nature genetics [Nat Genet] 2013 Sep; Vol. 45 (9), pp. 984-94. Date of Electronic Publication: 2013 Aug 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Predisposition to Disease*
Genome-Wide Association Study*
Polymorphism, Single Nucleotide*
Mental Disorders/*genetics
Adult ; Attention Deficit Disorder with Hyperactivity/genetics ; Bipolar Disorder/genetics ; Child ; Child Development Disorders, Pervasive/genetics ; Crohn Disease/genetics ; Depressive Disorder, Major/genetics ; Genetic Heterogeneity ; Genome, Human ; Humans ; Inheritance Patterns ; Schizophrenia/genetics
Czasopismo naukowe
Tytuł :
Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error.
Autorzy :
Stambolian D; Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, USA..
Wojciechowski R
Oexle K
Pirastu M
Li X
Raffel LJ
Cotch MF
Chew EY
Klein B
Klein R
Wong TY
Simpson CL
Klaver CC
van Duijn CM
Verhoeven VJ
Baird PN
Vitart V
Paterson AD
Mitchell P
Saw SM
Fossarello M
Kazmierkiewicz K
Murgia F
Portas L
Schache M
Richardson A
Xie J
Wang JJ
Rochtchina E
Viswanathan AC
Hayward C
Wright AF
Polasek O
Campbell H
Rudan I
Oostra BA
Uitterlinden AG
Hofman A
Rivadeneira F
Amin N
Karssen LC
Vingerling JR
Hosseini SM
Döring A
Bettecken T
Vatavuk Z
Gieger C
Wichmann HE
Wilson JF
Fleck B
Foster PJ
Topouzis F
McGuffin P
Sim X
Inouye M
Holliday EG
Attia J
Scott RJ
Rotter JI
Meitinger T
Bailey-Wilson JE
Pokaż więcej
Corporate Authors :
DCCT/EDIC Research Group
Źródło :
Human molecular genetics [Hum Mol Genet] 2013 Jul 01; Vol. 22 (13), pp. 2754-64. Date of Electronic Publication: 2013 Mar 07.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome-Wide Association Study*
RNA Splicing*
RNA-Binding Proteins/*genetics
Refractive Errors/*genetics
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Organ Specificity/genetics ; Polymorphism, Single Nucleotide ; RNA Isoforms/genetics ; RNA Splicing Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
Autorzy :
Verhoeven VJ; Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.
Hysi PG
Wojciechowski R
Fan Q
Guggenheim JA
Höhn R
MacGregor S
Hewitt AW
Nag A
Cheng CY
Yonova-Doing E
Zhou X
Ikram MK
Buitendijk GH
McMahon G
Kemp JP
Pourcain BS
Simpson CL
Mäkelä KM
Lehtimäki T
Kähönen M
Paterson AD
Hosseini SM
Wong HS
Xu L
Jonas JB
Pärssinen O
Wedenoja J
Yip SP
Ho DW
Pang CP
Chen LJ
Burdon KP
Craig JE
Klein BE
Klein R
Haller T
Metspalu A
Khor CC
Tai ES
Aung T
Vithana E
Tay WT
Barathi VA
Chen P
Li R
Liao J
Zheng Y
Ong RT
Döring A
Evans DM
Timpson NJ
Verkerk AJ
Meitinger T
Raitakari O
Hawthorne F
Spector TD
Karssen LC
Pirastu M
Murgia F
Ang W
Mishra A
Montgomery GW
Pennell CE
Cumberland PM
Cotlarciuc I
Mitchell P
Wang JJ
Schache M
Janmahasatian S
Igo RP Jr
Lass JH
Chew E
Iyengar SK
Gorgels TG
Rudan I
Hayward C
Wright AF
Polasek O
Vatavuk Z
Wilson JF
Fleck B
Zeller T
Mirshahi A
Müller C
Uitterlinden AG
Rivadeneira F
Vingerling JR
Hofman A
Oostra BA
Amin N
Bergen AA
Teo YY
Rahi JS
Vitart V
Williams C
Baird PN
Wong TY
Oexle K
Pfeiffer N
Mackey DA
Young TL
van Duijn CM
Saw SM
Bailey-Wilson JE
Stambolian D
Klaver CC
Hammond CJ
Pokaż więcej
Corporate Authors :
Consortium for Refractive Error and Myopia (CREAM)
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group
Wellcome Trust Case Control Consortium 2 (WTCCC2)
Fuchs' Genetics Multi-Center Study Group
Źródło :
Nature genetics [Nat Genet] 2013 Mar; Vol. 45 (3), pp. 314-8. Date of Electronic Publication: 2013 Feb 10.
Typ publikacji :
Journal Article; Meta-Analysis; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome-Wide Association Study*
Myopia/*genetics
Refractive Errors/*genetics
Alcohol Oxidoreductases/genetics ; Asian Continental Ancestry Group/genetics ; Bone Morphogenetic Protein 2/genetics ; European Continental Ancestry Group/genetics ; Genetic Predisposition to Disease ; Homeodomain Proteins/genetics ; Humans ; KCNQ Potassium Channels/genetics ; Laminin/genetics ; Receptors, AMPA/genetics ; Risk Factors ; Serine Proteases/genetics ; Trans-Activators/genetics
Czasopismo naukowe
Tytuł :
Individual common variants exert weak effects on the risk for autism spectrum disorders.
Autorzy :
Anney R; Autism Genetics Group, Department of Psychiatry, School of Medicine, Trinity College, Dublin 8, Ireland.
Klei L
Pinto D
Almeida J
Bacchelli E
Baird G
Bolshakova N
Bölte S
Bolton PF
Bourgeron T
Brennan S
Brian J
Casey J
Conroy J
Correia C
Corsello C
Crawford EL
de Jonge M
Delorme R
Duketis E
Duque F
Estes A
Farrar P
Fernandez BA
Folstein SE
Fombonne E
Gilbert J
Gillberg C
Glessner JT
Green A
Green J
Guter SJ
Heron EA
Holt R
Howe JL
Hughes G
Hus V
Igliozzi R
Jacob S
Kenny GP
Kim C
Kolevzon A
Kustanovich V
Lajonchere CM
Lamb JA
Law-Smith M
Leboyer M
Le Couteur A
Leventhal BL
Liu XQ
Lombard F
Lord C
Lotspeich L
Lund SC
Magalhaes TR
Mantoulan C
McDougle CJ
Melhem NM
Merikangas A
Minshew NJ
Mirza GK
Munson J
Noakes C
Nygren G
Papanikolaou K
Pagnamenta AT
Parrini B
Paton T
Pickles A
Posey DJ
Poustka F
Ragoussis J
Regan R
Roberts W
Roeder K
Roge B
Rutter ML
Schlitt S
Shah N
Sheffield VC
Soorya L
Sousa I
Stoppioni V
Sykes N
Tancredi R
Thompson AP
Thomson S
Tryfon A
Tsiantis J
Van Engeland H
Vincent JB
Volkmar F
Vorstman JA
Wallace S
Wing K
Wittemeyer K
Wood S
Zurawiecki D
Zwaigenbaum L
Bailey AJ
Battaglia A
Cantor RM
Coon H
Cuccaro ML
Dawson G
Ennis S
Freitag CM
Geschwind DH
Haines JL
Klauck SM
McMahon WM
Maestrini E
Miller J
Monaco AP
Nelson SF
Nurnberger JI Jr
Oliveira G
Parr JR
Pericak-Vance MA
Piven J
Schellenberg GD
Scherer SW
Vicente AM
Wassink TH
Wijsman EM
Betancur C
Buxbaum JD
Cook EH
Gallagher L
Gill M
Hallmayer J
Paterson AD
Sutcliffe JS
Szatmari P
Vieland VJ
Hakonarson H
Devlin B
Pokaż więcej
Źródło :
Human molecular genetics [Hum Mol Genet] 2012 Nov 01; Vol. 21 (21), pp. 4781-92. Date of Electronic Publication: 2012 Jul 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Predisposition to Disease*
Genome-Wide Association Study*
Child Development Disorders, Pervasive/*genetics
Membrane Proteins/*genetics
Nerve Tissue Proteins/*genetics
Alleles ; Child ; Child Development Disorders, Pervasive/physiopathology ; Female ; Gene Frequency ; Genotype ; Humans ; Language Development ; Male ; Polymorphism, Single Nucleotide ; Risk Factors
Czasopismo naukowe
Tytuł :
Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort.
Autorzy :
Hotaling JM; Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA.
Waggott DR
Goldberg J
Jarvik G
Paterson AD
Cleary PA
Lachin J
Sarma A
Wessells H
Pokaż więcej
Corporate Authors :
DCCT/EDIC Research Group
Źródło :
The Journal of urology [J Urol] 2012 Aug; Vol. 188 (2), pp. 514-20. Date of Electronic Publication: 2012 Jun 15.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Loci*
Genome-Wide Association Study*
Antigens, CD/*genetics
Cell Adhesion Molecules, Neuronal/*genetics
Diabetes Mellitus, Type 1/*complications
Diabetes Mellitus, Type 1/*genetics
Erectile Dysfunction/*genetics
Fetal Proteins/*genetics
Alleles ; Chromosomes, Human, Pair 3/genetics ; Cohort Studies ; Diabetes Mellitus, Type 1/drug therapy ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Hypoglycemic Agents/administration & dosage ; Insulin/administration & dosage ; Male ; Pilot Projects ; Polymorphism, Single Nucleotide/genetics ; Risk Assessment
Czasopismo naukowe
Tytuł :
Genome-wide scan for loci of adolescent obesity and their relationship with blood pressure.
Autorzy :
Melka MG; The Hospital for Sick Children, Toronto, Canada.
Bernard M
Mahboubi A
Abrahamowicz M
Paterson AD
Syme C
Lourdusamy A
Schumann G
Leonard GT
Perron M
Richer L
Veillette S
Gaudet D
Paus T
Pausova Z
Pokaż więcej
Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2012 Jan; Vol. 97 (1), pp. E145-50. Date of Electronic Publication: 2011 Oct 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Loci*/genetics
Genetic Loci*/physiology
Genome-Wide Association Study*
Blood Pressure/*genetics
Obesity/*genetics
Adolescent ; Age of Onset ; Blood Pressure/physiology ; Body Mass Index ; Canada/epidemiology ; Child ; Chromosome Mapping ; Female ; Genetic Predisposition to Disease ; Humans ; Hypertension/complications ; Hypertension/genetics ; Male ; Obesity/complications ; Obesity/epidemiology ; Obesity/physiopathology ; Quebec/epidemiology ; Validation Studies as Topic
Czasopismo naukowe
Tytuł :
BR-squared: a practical solution to the winner's curse in genome-wide scans.
Autorzy :
Sun L; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada. />Dimitromanolakis A
Faye LL
Paterson AD
Waggott D
Bull SB
Pokaż więcej
Corporate Authors :
DCCT/EDIC Research Group
Źródło :
Human genetics [Hum Genet] 2011 May; Vol. 129 (5), pp. 545-52. Date of Electronic Publication: 2011 Jan 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Statistics, Nonparametric*
Genome-Wide Association Study/*statistics & numerical data
Gene Frequency ; Genetic Predisposition to Disease ; Glycated Hemoglobin A/genetics ; Humans ; Polymorphism, Single Nucleotide ; Psoriasis/genetics ; Quantitative Trait, Heritable ; Sample Size
Czasopismo naukowe

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