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Wyświetlanie 1-13 z 13
Tytuł:
A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups.
Autorzy:
Landowski M; Department of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA.
Bhute VJ; Department of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.; Department of Chemical Engineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.
Takimoto T; Department of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Grindel S; Department of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Shahi PK; Department of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA.; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Pattnaik BR; Department of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA.; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Ikeda S; Department of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA.
Ikeda A; Department of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA. .; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 14; Vol. 12 (1), pp. 756. Date of Electronic Publication: 2022 Jan 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation*
Eye/*metabolism
Lipid Metabolism/*genetics
Macular Degeneration/*etiology
Membrane Proteins/*genetics
Mitochondrial Proteins/*genetics
Animals ; Disease Models, Animal ; Humans ; Macular Degeneration/genetics ; Mice, Mutant Strains ; Mice
Czasopismo naukowe
Tytuł:
The Natural Product β-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis.
Autorzy:
Kenny HA; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
Hart PC; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
Kordylewicz K; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
Lal M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, Rockville, MD 20852, USA.
Shen M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, Rockville, MD 20852, USA.
Kara B; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
Chen YJ; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
Grassl N; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Alharbi Y; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI 53792, USA.
Pattnaik BR; Department of Pediatrics and Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Watters KM; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
Patankar MS; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI 53792, USA.
Ferrer M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, Rockville, MD 20852, USA.
Lengyel E; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
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Źródło:
Cancers [Cancers (Basel)] 2021 Aug 04; Vol. 13 (16). Date of Electronic Publication: 2021 Aug 04.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Hypoxic-ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina.
Autorzy:
Zaitoun IS; Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, WIMR 9418, Madison, WI, 53705, USA. .; McPherson Eye Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. .
Shahi PK; McPherson Eye Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Suscha A; Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, WIMR 9418, Madison, WI, 53705, USA.
Chan K; Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, WIMR 9418, Madison, WI, 53705, USA.; McPherson Eye Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
McLellan GJ; Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, WIMR 9418, Madison, WI, 53705, USA.; McPherson Eye Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
Pattnaik BR; Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, WIMR 9418, Madison, WI, 53705, USA.; McPherson Eye Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Sorenson CM; McPherson Eye Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Sheibani N; Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, WIMR 9418, Madison, WI, 53705, USA.; McPherson Eye Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 16; Vol. 11 (1), pp. 12670. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Ischemic Stroke/*physiopathology
Retina/*physiopathology
Animals ; Capillaries/pathology ; Disease Models, Animal ; Endothelial Cells/pathology ; Hypoxia/physiopathology ; Ischemia/physiopathology ; Mice ; Pericytes/pathology ; Retinal Neurons/pathology ; Retinal Vessels/physiopathology
Czasopismo naukowe
Tytuł:
Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditions.
Autorzy:
Gheware A; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India.; CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics) CSIR-IGIB, Delhi, 110007, India.; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Dholakia D; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India.; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Kannan S; Center for High Computing, CSIR- Central Leather Research Institute (CLRI), Chennai, 600020, India.
Panda L; Center for Translational Research in Lung Disease, CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Rani R; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India.; CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics) CSIR-IGIB, Delhi, 110007, India.; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Pattnaik BR; Center for Translational Research in Lung Disease, CSIR- IGIB, Delhi, 110007, India.
Jain V; Center for Translational Research in Lung Disease, CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Parekh Y; CSIR-Center for Cellular and Molecular Biology, Annexe-II, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, 500007, India.
Enayathullah MG; CSIR-Center for Cellular and Molecular Biology, Annexe-II, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, 500007, India.
Bokara KK; CSIR-Center for Cellular and Molecular Biology, Annexe-II, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, 500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Subramanian V; Center for High Computing, CSIR- Central Leather Research Institute (CLRI), Chennai, 600020, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Mukerji M; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India.; CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics) CSIR-IGIB, Delhi, 110007, India.; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Agrawal A; Center for Translational Research in Lung Disease, CSIR- IGIB, Delhi, 110007, India. .; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. .
Prasher B; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India. .; CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics) CSIR-IGIB, Delhi, 110007, India. .; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India. .; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. .
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Źródło:
Respiratory research [Respir Res] 2021 Apr 06; Vol. 22 (1), pp. 99. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
Justicia*/chemistry
COVID-19 Drug Treatment*
Anti-Inflammatory Agents/*pharmacology
Hypoxia/*drug therapy
Lung/*drug effects
Plant Extracts/*pharmacology
Pneumonia/*prevention & control
Pulmonary Fibrosis/*drug therapy
Sepsis/*drug therapy
Animals ; Anti-Inflammatory Agents/isolation & purification ; Bleomycin ; COVID-19/metabolism ; COVID-19/virology ; Cecum/microbiology ; Cecum/surgery ; Cytokines/genetics ; Cytokines/metabolism ; Disease Models, Animal ; Hypoxia/genetics ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Hypoxia-Inducible Factor-Proline Dioxygenases/genetics ; Hypoxia-Inducible Factor-Proline Dioxygenases/metabolism ; Inflammation Mediators/metabolism ; Ligation ; Lung/metabolism ; Lung/microbiology ; Lung/pathology ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Plant Extracts/isolation & purification ; Pneumonia/genetics ; Pneumonia/metabolism ; Pneumonia/microbiology ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/genetics ; Pulmonary Fibrosis/metabolism ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Sepsis/genetics ; Sepsis/metabolism ; Sepsis/microbiology ; Transcriptome ; Mice
Czasopismo naukowe
Tytuł:
Oxidative stress induced by the anti-cancer agents, plumbagin, and atovaquone, inhibits ion transport through Na -ATPase.
Autorzy:
Alharbi Y; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53792, USA.; Department of Veterinary Medicine, Qassim University, Qassim, Saudi Arabia.
Kapur A; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53792, USA.
Felder M; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53792, USA.
Barroilhet L; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53792, USA.
Pattnaik BR; Department of Pediatrics, Ophthalmology and Visual Sciences, McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, 53706, USA. pattnaik@wisc.edu.
Patankar MS; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53792, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Nov 11; Vol. 10 (1), pp. 19585. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Atovaquone/*pharmacology
Naphthoquinones/*pharmacology
Ovarian Neoplasms/*drug therapy
Oxidative Stress/*drug effects
Sodium-Potassium-Exchanging ATPase/*metabolism
Adenosine Triphosphate/metabolism ; Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Enzyme Inhibitors/pharmacology ; Female ; Humans ; Ion Transport/drug effects ; Mice ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Oxidative Stress/physiology ; Patch-Clamp Techniques
Czasopismo naukowe
Tytuł:
Sensing through Non-Sensing Ocular Ion Channels.
Autorzy:
Kabra M; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI 53706, USA.
Pattnaik BR; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI 53706, USA.; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 21; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 21.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Channelopathies*/genetics
Channelopathies*/metabolism
Channelopathies*/pathology
Channelopathies*/therapy
Eye Diseases, Hereditary*/genetics
Eye Diseases, Hereditary*/metabolism
Eye Diseases, Hereditary*/pathology
Eye Diseases, Hereditary*/therapy
Genetic Diseases, X-Linked*/genetics
Genetic Diseases, X-Linked*/metabolism
Genetic Diseases, X-Linked*/pathology
Genetic Diseases, X-Linked*/therapy
Ion Channels*/genetics
Ion Channels*/metabolism
Leber Congenital Amaurosis*/genetics
Leber Congenital Amaurosis*/metabolism
Leber Congenital Amaurosis*/pathology
Leber Congenital Amaurosis*/therapy
Myopia*/genetics
Myopia*/metabolism
Myopia*/pathology
Myopia*/therapy
Night Blindness*/genetics
Night Blindness*/metabolism
Night Blindness*/pathology
Night Blindness*/therapy
Retinitis Pigmentosa*/genetics
Retinitis Pigmentosa*/metabolism
Retinitis Pigmentosa*/pathology
Retinitis Pigmentosa*/therapy
Animals ; Disease Models, Animal ; Humans
SCR Disease Name:
Night blindness, congenital stationary
Czasopismo naukowe
Tytuł:
Plumbagin-induced oxidative stress leads to inhibition of Na -ATPase (NKA) in canine cancer cells.
Autorzy:
Alharbi Y; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI-53792, USA.; Department of Veterinary Medicine, Qassim University, Qassim, Saudi Arabia.
Kapur A; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI-53792, USA.
Felder M; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI-53792, USA.
Barroilhet L; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI-53792, USA.
Stein T; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI-53792, USA.; Austin Veterinary, Austin, TX, 78730, USA.
Pattnaik BR; Department of Pediatrics and Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI-53706, USA. pattnaik@wisc.edu.
Patankar MS; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI-53792, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Aug 07; Vol. 9 (1), pp. 11471. Date of Electronic Publication: 2019 Aug 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Membrane Potentials/*drug effects
Naphthoquinones/*pharmacology
Neoplasms/*drug therapy
Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors
Acetylcysteine/pharmacology ; Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dogs ; Drug Screening Assays, Antitumor ; Naphthoquinones/therapeutic use ; Neoplasms/pathology ; Oxidative Phosphorylation/drug effects ; Oxidative Stress/drug effects ; Patch-Clamp Techniques ; Reactive Oxygen Species/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
Czasopismo naukowe
Tytuł:
Pregnancy-adapted uterine artery endothelial cell Ca2+ signaling and its relationship with membrane potential.
Autorzy:
Alvarez RE; Perinatal Research Laboratories, Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin.
Boeldt DS; Perinatal Research Laboratories, Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin.
Pattnaik BR; Department of Pediatrics, University of Wisconsin, Madison, Wisconsin.; Department of Ophthalmology and Vision Sciences, University of Wisconsin, Madison, Wisconsin.
Friedman HL; Perinatal Research Laboratories, Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin.
Bird IM; Perinatal Research Laboratories, Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin .; Department of Pediatrics, University of Wisconsin, Madison, Wisconsin.
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Źródło:
Physiological reports [Physiol Rep] 2017 Nov; Vol. 5 (21).
Typ publikacji:
Journal Article
MeSH Terms:
Calcium Signaling*
Membrane Potentials*
Pregnancy, Animal*
Endothelial Cells/*physiology
Uterine Artery/*physiology
Adenosine Triphosphate/administration & dosage ; Adenosine Triphosphate/physiology ; Animals ; Connexin 43/metabolism ; Endothelial Cells/metabolism ; Female ; Pregnancy ; Sheep ; TRPC Cation Channels/metabolism ; Uterine Artery/metabolism
Czasopismo naukowe
Tytuł:
Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosa.
Autorzy:
Yang H; Department of Surgery, Wisconsin Institute for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Fu Y; Department of Surgery, Wisconsin Institute for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China.
Liu X; Department of Pediatrics, Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, SMI 112, Madison, WI, 53706, USA.
Shahi PK; Department of Pediatrics, Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, SMI 112, Madison, WI, 53706, USA.
Mavlyutov TA; Department of Anesthesiology, Wisconsin Institute for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Li J; Department of Surgery, Wisconsin Institute for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.; Department of Ophthalmology, the First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.; Department of Ophthalmology, the 3rd People's Hospital of Dalian, Dalian, 116033, People's Republic of China.
Yao A; Department of Surgery, Wisconsin Institute for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Guo SZ; Department of Surgery, Wisconsin Institute for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Pattnaik BR; Department of Pediatrics, Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, SMI 112, Madison, WI, 53706, USA. pattnaik@wisc.edu.; McPherson Eye Research Institute, University of Wisconsin, Madison, WI, 53705, USA. pattnaik@wisc.edu.
Guo LW; Department of Surgery, Wisconsin Institute for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA. .; McPherson Eye Research Institute, University of Wisconsin, Madison, WI, 53705, USA. .; Department of Surgery and Department of Physiology &Cell Biology, the Ohio State University, Columbus, OH, 43210, USA. .
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Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2017 Sep 19; Vol. 12 (1), pp. 68. Date of Electronic Publication: 2017 Sep 19.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, sigma/*metabolism
Retinal Cone Photoreceptor Cells/*metabolism
Retinal Rod Photoreceptor Cells/*metabolism
Retinitis Pigmentosa/*metabolism
Animals ; Disease Models, Animal ; Mice ; Mice, Knockout ; Nerve Degeneration/metabolism ; Nerve Degeneration/pathology ; Retinal Cone Photoreceptor Cells/pathology ; Retinal Rod Photoreceptor Cells/pathology ; Retinitis Pigmentosa/pathology ; Sigma-1 Receptor
Czasopismo naukowe
Tytuł:
Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration.
Autorzy:
Zhao L; Department of Surgery, 5151 Wisconsin Institute for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Li J; Department of Surgery, 5151 Wisconsin Institute for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.; Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.; Department of Ophthalmology, The 3rd People's Hospital of Dalian, Dalian, 116033, People's Republic of China.
Fu Y; Department of Surgery, 5151 Wisconsin Institute for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China.
Zhang M; Department of Surgery, 5151 Wisconsin Institute for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Wang B; Department of Surgery, 5151 Wisconsin Institute for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Ouellette J; Department of Comparative Biosciences, University of Wisconsin, Madison, WI, 53706, USA.
Shahi PK; Department of Pediatrics, University of Wisconsin, Madison, WI, USA.; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA.
Pattnaik BR; Department of Pediatrics, University of Wisconsin, Madison, WI, USA.; McPherson Eye Research Institute, University of Wisconsin, Madison, WI, 53705, USA.; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA.
Watters JJ; Department of Comparative Biosciences, University of Wisconsin, Madison, WI, 53706, USA.
Wong WT; Unit on Neuron-Glia Interactions in Retinal Disease, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Guo LW; Department of Surgery, 5151 Wisconsin Institute for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA. .; McPherson Eye Research Institute, University of Wisconsin, Madison, WI, 53705, USA. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2017 Jan 19; Vol. 14 (1), pp. 14. Date of Electronic Publication: 2017 Jan 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Disease Models, Animal*
Epigenesis, Genetic/*physiology
Nerve Tissue Proteins/*deficiency
Photoreceptor Cells/*metabolism
Receptors, Cell Surface/*deficiency
Retinitis Pigmentosa/*metabolism
Animals ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Photoreceptor Cells/pathology ; Receptors, Cell Surface/genetics ; Retinal Degeneration/genetics ; Retinal Degeneration/metabolism ; Retinal Degeneration/pathology ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/pathology
Czasopismo naukowe
Tytuł:
Snowflake vitreoretinal degeneration (SVD) mutation R162W provides new insights into Kir7.1 ion channel structure and function.
Autorzy:
Pattnaik BR; Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, United States of America ; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, United States of America ; McPherson Eye Research Institute, University of Wisconsin, Madison, Wisconsin, United States of America.
Tokarz S
Asuma MP
Schroeder T
Sharma A
Mitchell JC
Edwards AO
Pillers DA
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Źródło:
PloS one [PLoS One] 2013 Aug 19; Vol. 8 (8), pp. e71744. Date of Electronic Publication: 2013 Aug 19 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation/*genetics
Potassium Channels, Inwardly Rectifying/*chemistry
Potassium Channels, Inwardly Rectifying/*genetics
Retinal Degeneration/*genetics
Amino Acid Sequence ; Amino Acid Substitution/genetics ; Animals ; CHO Cells ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cricetinae ; Cricetulus ; HEK293 Cells ; Humans ; Ion Channel Gating/drug effects ; Macaca mulatta ; Models, Molecular ; Molecular Sequence Data ; Mutant Proteins/metabolism ; Potassium Channels, Inwardly Rectifying/metabolism ; Protein Structure, Tertiary ; Protein Transport/drug effects ; Retina/drug effects ; Retina/metabolism ; Rubidium/pharmacology ; Structural Homology, Protein ; Transfection
SCR Disease Name:
Snowflake vitreoretinal degeneration
Czasopismo naukowe
Tytuł:
Terpenoids from Zingiber officinale (Ginger) induce apoptosis in endometrial cancer cells through the activation of p53.
Autorzy:
Liu Y; Department of Obstetrics and Gynecology, Shandong University, Qi Lu Hospital, Ji Nan, China.
Whelan RJ
Pattnaik BR
Ludwig K
Subudhi E
Rowland H
Claussen N
Zucker N
Uppal S
Kushner DM
Felder M
Patankar MS
Kapur A
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (12), pp. e53178. Date of Electronic Publication: 2012 Dec 31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Zingiber officinale*
Apoptosis/*drug effects
Endometrial Neoplasms/*drug therapy
Plant Extracts/*pharmacology
Terpenes/*pharmacology
Tumor Suppressor Protein p53/*metabolism
Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Endometrial Neoplasms/metabolism ; Female ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Plant Extracts/therapeutic use ; Terpenes/therapeutic use
Czasopismo naukowe
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