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Wyświetlanie 1-20 z 39
Tytuł:
Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns.
Autorzy:
Moore AS
Faisal A
Gonzalez de Castro D
Bavetsias V
Sun C
Atrash B
Valenti M
de Haven Brandon A
Avery S
Mair D
Mirabella F
Swansbury J
Pearson AD
Workman P
Blagg J
Raynaud FI
Eccles SA
Linardopoulos S
Moore, A S
Faisal, A
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Źródło:
Leukemia (08876924); Jul2012, Vol. 26 Issue 7, p1462-1470, 9p
Czasopismo naukowe
Szczegóły
Tytuł:
Transition states. Trapping a transition state in a computationally designed protein bottle.
Autorzy:
Pearson AD; Department of Chemistry, and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Mills JH; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
Song Y; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
Nasertorabi F; Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089.
Han GW; Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089.
Baker D; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.; Howard Hughes Medical Institute (HHMI), University of Washington, Seattle, WA 98195, USA.
Stevens RC; Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089.
Schultz PG; Department of Chemistry, and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2015 Feb 20; Vol. 347 (6224), pp. 863-867.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Alanine/*analogs & derivatives
Archaeal Proteins/*chemistry
Biphenyl Compounds/*chemistry
Pyrococcus abyssi/*enzymology
Threonine-tRNA Ligase/*chemistry
Alanine/chemistry ; Computer Simulation ; Computer-Aided Design ; Crystallography, X-Ray ; Entropy ; Models, Chemical ; Protein Structure, Secondary ; Software
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Lactate and choline metabolites detected in vitro by nuclear magnetic resonance spectroscopy are potential metabolic biomarkers for PI3K inhibition in pediatric glioblastoma.
Autorzy:
Al-Saffar NM; Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Marshall LV; Division of Molecular Pathology, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom; Division of Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom; Division of Clinical Studies. The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Jackson LE; Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Balarajah G; Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Eykyn TR; Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom; Division of Imaging Sciences and Biomedical Engineering, King's College London, St Thomas' Hospital, London, United Kingdom.
Agliano A; Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Clarke PA; Division of Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.
Jones C; Division of Molecular Pathology, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom; Division of Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Workman P; Division of Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.
Pearson AD; Division of Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom; Division of Clinical Studies. The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Leach MO; Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.
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Źródło:
PloS one [PLoS One] 2014 Aug 01; Vol. 9 (8), pp. e103835. Date of Electronic Publication: 2014 Aug 01 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Choline/*metabolism
Glioblastoma/*enzymology
Glioblastoma/*metabolism
Lactic Acid/*metabolism
Magnetic Resonance Spectroscopy/*methods
Phosphatidylinositol 3-Kinases/*metabolism
Cell Line, Tumor ; Flow Cytometry ; Humans ; Immunoblotting
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Intrinsic susceptibility MRI identifies tumors with ALKF1174L mutation in genetically-engineered murine models of high-risk neuroblastoma.
Autorzy:
Jamin Y; Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom.
Glass L; Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom; Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom; Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom.
Hallsworth A; Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.
George R; Department of Pediatric Haematology and Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America.
Koh DM; Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom.
Pearson AD; Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom.
Chesler L; Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom; Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom; Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom.
Robinson SP; Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom.
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Źródło:
PloS one [PLoS One] 2014 Mar 25; Vol. 9 (3), pp. e92886. Date of Electronic Publication: 2014 Mar 25 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Engineering*
Mutation, Missense*
Neoplasms, Experimental*/genetics
Neoplasms, Experimental*/metabolism
Neoplasms, Experimental*/pathology
Neuroblastoma*/genetics
Neuroblastoma*/metabolism
Neuroblastoma*/pathology
Receptor Protein-Tyrosine Kinases*/genetics
Receptor Protein-Tyrosine Kinases*/metabolism
Amino Acid Substitution ; Anaplastic Lymphoma Kinase ; Animals ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Mice, Transgenic ; N-Myc Proto-Oncogene Protein ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Novel therapies for children with acute myeloid leukaemia.
Autorzy:
Moore AS; Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Australia. />Kearns PR
Knapper S
Pearson AD
Zwaan CM
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Źródło:
Leukemia [Leukemia] 2013 Jul; Vol. 27 (7), pp. 1451-60. Date of Electronic Publication: 2013 Apr 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Adenine Nucleotides/*therapeutic use
Aminoglycosides/*therapeutic use
Antibodies, Monoclonal, Humanized/*therapeutic use
Arabinonucleosides/*therapeutic use
Leukemia, Monocytic, Acute/*drug therapy
Niacinamide/*analogs & derivatives
Phenylurea Compounds/*therapeutic use
Antineoplastic Agents/therapeutic use ; Child ; Clofarabine ; Gemtuzumab ; Humans ; Immunotoxins/therapeutic use ; Niacinamide/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Sorafenib
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project.
Autorzy:
Schleiermacher G; INSERM U, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France. />Mosseri V
London WB
Maris JM
Brodeur GM
Attiyeh E
Haber M
Khan J
Nakagawara A
Speleman F
Noguera R
Tonini GP
Fischer M
Ambros I
Monclair T
Matthay KK
Ambros P
Cohn SL
Pearson AD
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2012 Oct 09; Vol. 107 (8), pp. 1418-22. Date of Electronic Publication: 2012 Sep 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neuroblastoma/*genetics
Nuclear Proteins/*genetics
Oncogene Proteins/*genetics
Chromosome Aberrations ; Chromosomes, Human, Pair 11/genetics ; Chromosomes, Human, Pair 17/genetics ; Humans ; Infant ; N-Myc Proto-Oncogene Protein ; Prognosis ; Retrospective Studies ; Survival Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Criteria for evaluation of disease extent by (123)I-metaiodobenzylguanidine scans in neuroblastoma: a report for the International Neuroblastoma Risk Group (INRG) Task Force.
Autorzy:
Matthay KK; Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA 94143-0106, USA. />Shulkin B
Ladenstein R
Michon J
Giammarile F
Lewington V
Pearson AD
Cohn SL
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2010 Apr 27; Vol. 102 (9), pp. 1319-26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
3-Iodobenzylguanidine*
Iodine Radioisotopes*
Bone Neoplasms/*secondary
Neuroblastoma/*diagnostic imaging
Soft Tissue Neoplasms/*secondary
Advisory Committees ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/pathology ; Child ; Female ; Humans ; Neoplasm Metastasis/diagnostic imaging ; Neoplasm Metastasis/pathology ; Neoplasm Staging/methods ; Neuroblastoma/pathology ; Practice Guidelines as Topic ; Radiation Injuries/epidemiology ; Radiation Injuries/prevention & control ; Radiographic Image Enhancement ; Radiopharmaceuticals ; Soft Tissue Neoplasms/diagnostic imaging ; Soft Tissue Neoplasms/pathology ; Tomography, Emission-Computed, Single-Photon/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias.
Autorzy:
Moore AS; Section of Paediatric Oncology, The Institute of Cancer Research, Sutton, UK. />Blagg J
Linardopoulos S
Pearson AD
Pokaż więcej
Źródło:
Leukemia [Leukemia] 2010 Apr; Vol. 24 (4), pp. 671-8. Date of Electronic Publication: 2010 Feb 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy
Leukemia, Myeloid, Acute/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Protein Serine-Threonine Kinases/*antagonists & inhibitors
Aurora Kinase B ; Aurora Kinases ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/enzymology ; Leukemia, Myeloid, Acute/enzymology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Consensus criteria for sensitive detection of minimal neuroblastoma cells in bone marrow, blood and stem cell preparations by immunocytology and QRT-PCR: recommendations by the International Neuroblastoma Risk Group Task Force.
Autorzy:
Beiske K; Department of Pathology, Oslo University Hospital, Oslo, Norway. />Burchill SA
Cheung IY
Hiyama E
Seeger RC
Cohn SL
Pearson AD
Matthay KK
Pokaż więcej
Corporate Authors:
International neuroblastoma Risk Group Task Force
Źródło:
British journal of cancer [Br J Cancer] 2009 May 19; Vol. 100 (10), pp. 1627-37. Date of Electronic Publication: 2009 Apr 28.
Typ publikacji:
Journal Article; Multicenter Study; Practice Guideline; Research Support, Non-U.S. Gov't
MeSH Terms:
Bone Marrow/*pathology
Immunohistochemistry/*standards
Neoplastic Cells, Circulating/*pathology
Neoplastic Stem Cells/*pathology
Neuroblastoma/*diagnosis
Reverse Transcriptase Polymerase Chain Reaction/*standards
Advisory Committees ; Algorithms ; Consensus ; Health Planning Guidelines ; Humans ; Immunohistochemistry/methods ; Neoplasm, Residual ; Neuroblastoma/blood ; Neuroblastoma/pathology ; Reference Standards ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Sensitivity and Specificity ; Specimen Handling/methods ; Specimen Handling/standards
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee.
Autorzy:
Ambros PF; CCRI, Children's Cancer Research Institute, Vienna, Austria. />Ambros IM
Brodeur GM
Haber M
Khan J
Nakagawara A
Schleiermacher G
Speleman F
Spitz R
London WB
Cohn SL
Pearson AD
Maris JM
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2009 May 05; Vol. 100 (9), pp. 1471-82.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neuroblastoma/*diagnosis
Neuroblastoma/*genetics
Chromosome Aberrations ; Chromosomes, Human, Pair 11 ; Chromosomes, Human, Pair 17 ; Consensus ; Gene Amplification ; Genetic Markers ; Humans ; International Cooperation ; N-Myc Proto-Oncogene Protein ; Neuroblastoma/epidemiology ; Neuroblastoma/psychology ; Neuroblastoma/therapy ; Nuclear Proteins/genetics ; Oncogene Proteins/genetics ; Patient Care Planning ; Ploidies ; Prognosis ; Protein Biosynthesis ; Risk Assessment ; Risk Factors ; Survival Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.
Autorzy:
Bax DA; Paediatric Oncology, The Institute of Cancer Research, Sutton, United Kingdom.
Little SE
Gaspar N
Perryman L
Marshall L
Viana-Pereira M
Jones TA
Williams RD
Grigoriadis A
Vassal G
Workman P
Sheer D
Reis RM
Pearson AD
Hargrave D
Jones C
Pokaż więcej
Źródło:
PloS one [PLoS One] 2009; Vol. 4 (4), pp. e5209. Date of Electronic Publication: 2009 Apr 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Line, Tumor*/metabolism
Cell Line, Tumor*/pathology
Drug Design*
Glioma*/genetics
Glioma*/metabolism
Glioma*/pathology
Phenotype*
Adult ; Astrocytes/metabolism ; Biomarkers/metabolism ; Child ; Chromosome Aberrations ; Enzyme Activation ; Epigenesis, Genetic ; Gene Expression Profiling ; Humans ; Immunophenotyping ; Loss of Heterozygosity ; Mitogen-Activated Protein Kinases/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction/physiology ; Stem Cells/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Treatment of localised resectable neuroblastoma. Results of the LNESG1 study by the SIOP Europe Neuroblastoma Group.
Autorzy:
De Bernardi B; Department of Paediatric Haematology and Oncology, Giannina Gaslini Children's Hospital, Genova, Italy. />Mosseri V
Rubie H
Castel V
Foot A
Ladenstein R
Laureys G
Beck-Popovic M
de Lacerda AF
Pearson AD
De Kraker J
Ambros PF
de Rycke Y
Conte M
Bruzzi P
Michon J
Pokaż więcej
Corporate Authors:
SIOP Europe Neuroblastoma Group
Źródło:
British journal of cancer [Br J Cancer] 2008 Oct 07; Vol. 99 (7), pp. 1027-33. Date of Electronic Publication: 2008 Sep 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neuroblastoma/*surgery
Disease Progression ; Disease-Free Survival ; Europe ; Female ; Genes, myc ; Humans ; Infant ; Infant, Newborn ; Male ; Neuroblastoma/genetics ; Prognosis ; Recurrence ; Survival Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
28 years of high-dose therapy and SCT for neuroblastoma in Europe: lessons from more than 4000 procedures.
Autorzy:
Ladenstein R; St Anna Kinderspital, Kinderspitalgasse, Vienna, Austria. />Pötschger U
Hartman O
Pearson AD
Klingebiel T
Castel V
Yaniv I
Demirer T
Dini G
Pokaż więcej
Corporate Authors:
EBMT Paediatric Working Party
Źródło:
Bone marrow transplantation [Bone Marrow Transplant] 2008 Jun; Vol. 41 Suppl 2, pp. S118-27.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols*
Registries*
Hematopoietic Stem Cell Transplantation/*mortality
Neuroblastoma/*therapy
Adolescent ; Adult ; Age Factors ; Child ; Child, Preschool ; Disease-Free Survival ; Europe/epidemiology ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Infant ; Middle Aged ; Neuroblastoma/drug therapy ; Remission Induction/methods ; Transplantation, Autologous
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 39

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