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Tytuł :
Long noncoding RNA HAGLROS regulates apoptosis and autophagy in Parkinson's disease via regulating miR-100/ATG10 axis and PI3K/Akt/mTOR pathway activation.
Autorzy :
Peng T; a Department of Neurology, Key-Disciplines Laboratory Clinical Medicine of Henan, The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
Liu X; a Department of Neurology, Key-Disciplines Laboratory Clinical Medicine of Henan, The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
Wang J; a Department of Neurology, Key-Disciplines Laboratory Clinical Medicine of Henan, The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
Liu Y; a Department of Neurology, Key-Disciplines Laboratory Clinical Medicine of Henan, The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
Fu Z; a Department of Neurology, Key-Disciplines Laboratory Clinical Medicine of Henan, The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
Ma X; a Department of Neurology, Key-Disciplines Laboratory Clinical Medicine of Henan, The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
Li J; a Department of Neurology, Key-Disciplines Laboratory Clinical Medicine of Henan, The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
Sun G; a Department of Neurology, Key-Disciplines Laboratory Clinical Medicine of Henan, The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
Ji Y; a Department of Neurology, Key-Disciplines Laboratory Clinical Medicine of Henan, The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
Lu J; a Department of Neurology, Key-Disciplines Laboratory Clinical Medicine of Henan, The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
Wan W; b Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
Lu H; a Department of Neurology, Key-Disciplines Laboratory Clinical Medicine of Henan, The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2019 Dec; Vol. 47 (1), pp. 2764-2774.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*genetics
Autophagy/*genetics
Autophagy-Related Proteins/*genetics
MicroRNAs/*genetics
Parkinson Disease/*genetics
Parkinson Disease/*pathology
RNA, Long Noncoding/*genetics
Vesicular Transport Proteins/*genetics
Animals ; Cell Line, Tumor ; Gene Expression Regulation/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats.
Autorzy :
Guo L; Clinical Anatomy & Reproductive Medicine Application Institute, School of Medicine, University of South China, Hengyang 421001, People's Republic of China.
Li Y; National Key Discipline of Human Anatomy, Southern Medical University, Guangzhou 510000, Guangdong, People's Republic of China.; Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangzhou, 510000, Guangdong, People's Republic of China.
Tian Y; Institute of Clinical Research, Affiliated Nanhua Hospital, University of South China, Hengyang 421002, Hunan, People's Republic of China.; Postdoctoral Research Institute on Basic Medicine, University of South China, Hengyang, 421001, Hunan, People's Republic of China.
Gong S; Department of Pathology, First Affiliated Hospital, University of South China, Hengyang 421001, Hunan, People's Republic of China.
Chen X; Clinical Anatomy & Reproductive Medicine Application Institute, School of Medicine, University of South China, Hengyang 421001, People's Republic of China.
Peng T; Clinical Anatomy & Reproductive Medicine Application Institute, School of Medicine, University of South China, Hengyang 421001, People's Republic of China.
Wang A; Clinical Anatomy & Reproductive Medicine Application Institute, School of Medicine, University of South China, Hengyang 421001, People's Republic of China.; Institute of Clinical Research, Affiliated Nanhua Hospital, University of South China, Hengyang 421002, Hunan, People's Republic of China.; Postdoctoral Research Institute on Basic Medicine, University of South China, Hengyang, 421001, Hunan, People's Republic of China.; Key Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, University of South China, Hengyang 421001, Hunan, People's Republic of China.
Jiang Z; Key Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, University of South China, Hengyang 421001, Hunan, People's Republic of China.
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Źródło :
Drug design, development and therapy [Drug Des Devel Ther] 2019 Aug 13; Vol. 13, pp. 2799-2809. Date of Electronic Publication: 2019 Aug 13 (Print Publication: 2019).
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Vascular Remodeling*
Pulmonary Arterial Hypertension/*pathology
eIF-2 Kinase/*metabolism
Animals ; Cell Proliferation ; Male ; Monocrotaline ; Muscle, Smooth/drug effects ; Muscle, Smooth/metabolism ; Muscle, Smooth/pathology ; Pulmonary Arterial Hypertension/chemically induced ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Artery/drug effects ; Pulmonary Artery/metabolism ; Pulmonary Artery/pathology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Calpain-2 protects against heat stress-induced cardiomyocyte apoptosis and heart dysfunction by blocking p38 mitogen-activated protein kinase activation.
Autorzy :
Liu ZF; Department of Critical Care Medicine, General Hospital of Guangzhou Military Command, Guangzhou, China.; Department of Medicine, Critical Illness Research Center, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada.; Department of Pathology, Critical Illness Research Center, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada.
Ji JJ; Department of Critical Care Medicine, General Hospital of Guangzhou Military Command, Guangzhou, China.; Departement of Pathophysiology, Southern Medical University, Guangzhou, China.
Zheng D; Department of Medicine, Critical Illness Research Center, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada.; Department of Pathology, Critical Illness Research Center, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada.
Su L; Department of Critical Care Medicine, General Hospital of Guangzhou Military Command, Guangzhou, China.; Key Laboratory of Hot Zone Trauma Care and Tissue Repair of PLA, General Hospital of Guangzhou Military Command, Guangzhou, China.
Peng T; Department of Medicine, Critical Illness Research Center, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada.; Department of Pathology, Critical Illness Research Center, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2019 Jul; Vol. 234 (7), pp. 10761-10770. Date of Electronic Publication: 2018 Nov 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Heat-Shock Response*
Calpain/*metabolism
Heart Diseases/*prevention & control
Heat Stroke/*complications
Myocytes, Cardiac/*enzymology
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Calpain/genetics ; Cells, Cultured ; Disease Models, Animal ; Enzyme Activation ; Heart Diseases/enzymology ; Heart Diseases/etiology ; Heart Diseases/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Myocytes, Cardiac/pathology ; Phosphorylation ; Primary Cell Culture ; Signal Transduction ; Stroke Volume
Czasopismo naukowe
Tytuł :
Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis.
Autorzy :
Hong G; Department of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada N6A 4G5; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada N6A 4G5.
Zheng D; Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada N6A 4G5; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada N6A 4G5; Department of Medicine, Western University, London, Ontario, Canada N6A 4G5; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China.
Zhang L; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China.
Ni R; Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada N6A 4G5; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada N6A 4G5.
Wang G; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
Fan GC; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Lu Z; Department of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: .
Peng T; Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada N6A 4G5; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada N6A 4G5; Department of Medicine, Western University, London, Ontario, Canada N6A 4G5; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2018 Aug 01; Vol. 123, pp. 125-137. Date of Electronic Publication: 2018 May 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Apoptosis/*drug effects
Multiple Organ Failure/*prevention & control
Niacinamide/*analogs & derivatives
Oxidative Stress/*drug effects
Sepsis/*complications
Animals ; HMGB1 Protein/metabolism ; Lipopolysaccharides/toxicity ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Multiple Organ Failure/etiology ; Multiple Organ Failure/metabolism ; Niacinamide/administration & dosage ; Niacinamide/pharmacology ; Sepsis/chemically induced
Czasopismo naukowe
Tytuł :
A series of novel complexes firstly constructed by 1,4-phenylenedioxydiacetic acid plays a role in disruption of DNA gene expression and induction of apoptosis.
Autorzy :
Zhu M; International Key Laboratory of Liaoning Inorganic Molecule-Based Chemicals and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China.
Peng T; International Key Laboratory of Liaoning Inorganic Molecule-Based Chemicals and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China.
Sun N; International Key Laboratory of Liaoning Inorganic Molecule-Based Chemicals and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China.
Qiu X; International Key Laboratory of Liaoning Inorganic Molecule-Based Chemicals and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China.
Zhan Y; International Key Laboratory of Liaoning Inorganic Molecule-Based Chemicals and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China.
Ding Y; International Key Laboratory of Liaoning Inorganic Molecule-Based Chemicals and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China.
Zhang S; International Key Laboratory of Liaoning Inorganic Molecule-Based Chemicals and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China.
Gao E; International Key Laboratory of Liaoning Inorganic Molecule-Based Chemicals and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China. Electronic address: .
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Źródło :
Journal of inorganic biochemistry [J Inorg Biochem] 2018 Mar; Vol. 180, pp. 141-154. Date of Electronic Publication: 2017 Nov 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetates/*chemistry
Acetates/*pharmacology
Apoptosis/*drug effects
DNA/*genetics
Gene Expression/*drug effects
Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Binding, Competitive ; Catalysis ; Cell Line, Tumor ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; Humans ; Inhibitory Concentration 50 ; Metals/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Organic Chemicals/chemistry ; Powder Diffraction ; Spectrometry, Fluorescence ; Spectrophotometry, Infrared ; Thermogravimetry
Czasopismo naukowe
Tytuł :
Role of neurexin2a in lead-induced locomotor defect in developing zebrafish.
Autorzy :
Tu H; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Peng T; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Liu J; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Chen X; Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Fan C; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Huang Z; Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Zhang Y; Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Zou F; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China. Electronic address: .
Meng X; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China. Electronic address: .
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Źródło :
Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2018 Jan; Vol. 194, pp. 167-175. Date of Electronic Publication: 2017 Nov 22.
Typ publikacji :
Journal Article
MeSH Terms :
Swimming*
Apoptosis/*drug effects
Cell Adhesion Molecules, Neuronal/*genetics
Gene Expression Regulation/*drug effects
Lead/*toxicity
Nerve Tissue Proteins/*genetics
Water Pollutants, Chemical/*toxicity
Zebrafish/*genetics
Animals ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Zebrafish/metabolism
Czasopismo naukowe
Tytuł :
Everolimus Inhibits Growth of Gemcitabine-Resistant Pancreatic Cancer Cells via Induction of Caspase-Dependent Apoptosis and G 2 /M Arrest.
Autorzy :
Peng T; Pancreatic Disease Institute, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, P. R. China.; Departments of Oncology, Pharmacology, and Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Dou QP; Departments of Oncology, Pharmacology, and Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
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Źródło :
Journal of cellular biochemistry [J Cell Biochem] 2017 Sep; Vol. 118 (9), pp. 2722-2730. Date of Electronic Publication: 2017 Apr 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Caspase 3/*metabolism
Caspase 7/*metabolism
Deoxycytidine/*analogs & derivatives
Drug Resistance, Neoplasm/*drug effects
Everolimus/*pharmacology
G2 Phase Cell Cycle Checkpoints/*drug effects
M Phase Cell Cycle Checkpoints/*drug effects
Neoplasm Proteins/*metabolism
Pancreatic Neoplasms/*drug therapy
Cell Line, Tumor ; Enzyme Activation/drug effects ; Humans ; Pancreatic Neoplasms/enzymology ; Pancreatic Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Heat stress prevents lipopolysaccharide-induced apoptosis in pulmonary microvascular endothelial cells by blocking calpain/p38 MAPK signalling.
Autorzy :
Liu ZF; Department of Intensive Care Unit, General Hospital of Guangzhou Military Command, Guangzhou, 510010, China.; Departments of Medicine and Pathology, Critical Illness Research, Lawson Health Research Institute, University of Western Ontario, London, ON, N6A 4G5, Canada.
Zheng D; Departments of Medicine and Pathology, Critical Illness Research, Lawson Health Research Institute, University of Western Ontario, London, ON, N6A 4G5, Canada.
Fan GC; Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, 45267-0575, USA.
Peng T; Departments of Medicine and Pathology, Critical Illness Research, Lawson Health Research Institute, University of Western Ontario, London, ON, N6A 4G5, Canada.
Su L; Department of Intensive Care Unit, General Hospital of Guangzhou Military Command, Guangzhou, 510010, China. .; Key Laboratory of Hot Zone Trauma Care and Tissue Repair of PLA, General Hospital of Guangzhou Military Command, Guangzhou, 510010, China. .
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Źródło :
Apoptosis : an international journal on programmed cell death [Apoptosis] 2016 Aug; Vol. 21 (8), pp. 896-904.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Caspase 3/*metabolism
Endothelial Cells/*metabolism
Heat-Shock Response/*physiology
MAP Kinase Signaling System/*physiology
Microvessels/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Acute Lung Injury/metabolism ; Acute Lung Injury/physiopathology ; Animals ; Calpain/pharmacology ; Cell Line ; Down-Regulation/drug effects ; Down-Regulation/physiology ; Endothelial Cells/drug effects ; Endothelial Cells/physiology ; Female ; Hemangioendothelioma/metabolism ; Hemangioendothelioma/physiopathology ; Hot Temperature ; Lipopolysaccharides/pharmacology ; Lung/drug effects ; Lung/metabolism ; Lung/physiology ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Microvessels/drug effects ; Microvessels/physiology ; Phosphorylation/drug effects ; Phosphorylation/physiology ; Sepsis/metabolism ; Sepsis/physiopathology ; Up-Regulation/drug effects ; Up-Regulation/physiology
Czasopismo naukowe
Tytuł :
Heat stress pretreatment decreases lipopolysaccharide-induced apoptosis via the p38 signaling pathway in human umbilical vein endothelial cells.
Autorzy :
Liu Z; Department of Intensive Care Unit, General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China.
Zhong T; Department of Intensive Care Unit, General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China.
Zheng D; Critical Illness Research Centre, Lawson Health Research Institute, University of Western Ontario, London, ON N6A 4G5, Canada.
Cepinskas I; Critical Illness Research Centre, Lawson Health Research Institute, University of Western Ontario, London, ON N6A 4G5, Canada.
Peng T; Critical Illness Research Centre, Lawson Health Research Institute, University of Western Ontario, London, ON N6A 4G5, Canada.
Su L; Department of Intensive Care Unit, General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2016 Jul; Vol. 14 (1), pp. 1007-13. Date of Electronic Publication: 2016 May 18.
Typ publikacji :
Journal Article
MeSH Terms :
Heat-Shock Response*
MAP Kinase Signaling System*
Apoptosis/*drug effects
Human Umbilical Vein Endothelial Cells/*metabolism
Lipopolysaccharides/*pharmacology
p38 Mitogen-Activated Protein Kinases/*metabolism
Caspase 3/metabolism ; Cells, Cultured ; DNA Fragmentation ; Gene Expression ; HSP27 Heat-Shock Proteins/genetics ; HSP27 Heat-Shock Proteins/metabolism ; HSP90 Heat-Shock Proteins/genetics ; HSP90 Heat-Shock Proteins/metabolism ; Hot Temperature ; Humans ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism
Czasopismo naukowe
Tytuł :
Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis.
Autorzy :
Zheng D; Jiangsu Key Laboratory of Infection and Immunity, Institutes for Biology and Medical Sciences, Soochow University, Suzhou Lawson Health Research Institute Department of Medicine Department of Pathology, University of Western Ontario, London, Canada.
Yu Y; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China.
Li M; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China.
Wang G; Department of Pathology, University of Western Ontario, London, Canada.
Chen R; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China.
Fan GC; Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Ohio.
Martin C; Lawson Health Research Institute Department of Medicine.
Xiong S; Jiangsu Key Laboratory of Infection and Immunity, Institutes for Biology and Medical Sciences, Soochow University, Suzhou.
Peng T; Jiangsu Key Laboratory of Infection and Immunity, Institutes for Biology and Medical Sciences, Soochow University, Suzhou Lawson Health Research Institute Department of Medicine Department of Pathology, University of Western Ontario, London, Canada.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2016 May 15; Vol. 213 (10), pp. 1661-70. Date of Electronic Publication: 2015 Dec 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Endotoxemia/*therapy
MicroRNAs/*antagonists & inhibitors
Multiple Organ Failure/*prevention & control
Sepsis/*therapy
Animals ; Disease Models, Animal ; Endothelial Cells/metabolism ; Endotoxemia/chemically induced ; Feces ; Humans ; Lipopolysaccharides/adverse effects ; Liver/metabolism ; Lung/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-pim-1/metabolism ; RNA Interference ; Sepsis/chemically induced ; Sirtuin 1/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Essential roles of Cdc42 and MAPK in cadmium-induced apoptosis in Litopenaeus vannamei.
Autorzy :
Peng T; Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, College of Life Science, South China Normal University, Guangzhou 510631, PR China.
Wang WN; Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, College of Life Science, South China Normal University, Guangzhou 510631, PR China. Electronic address: .
Gu MM; Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, College of Life Science, South China Normal University, Guangzhou 510631, PR China.
Xie CY; Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, College of Life Science, South China Normal University, Guangzhou 510631, PR China.
Xiao YC; Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, College of Life Science, South China Normal University, Guangzhou 510631, PR China.
Liu Y; Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, College of Life Science, South China Normal University, Guangzhou 510631, PR China.
Wang L; Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, College of Life Science, South China Normal University, Guangzhou 510631, PR China.
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Źródło :
Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2015 Jun; Vol. 163, pp. 89-96. Date of Electronic Publication: 2015 Apr 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Cadmium/*toxicity
Decapoda/*drug effects
Mitogen-Activated Protein Kinases/*metabolism
Water Pollutants, Chemical/*toxicity
cdc42 GTP-Binding Protein/*metabolism
Animals ; Decapoda/metabolism ; Hemocytes/cytology ; Hemocytes/drug effects ; Hemocytes/metabolism ; RNA Interference ; RNA, Double-Stranded/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; cdc42 GTP-Binding Protein/antagonists & inhibitors ; cdc42 GTP-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation.
Autorzy :
Zheng D; Institutes of Biology and Medical Science, Soochow University, Suzhou 215123, China; Critical Illness Research, Lawson Health Research Institute, Canada; Department of Medicine, University of Western Ontario, London, Ontario N6A 4G5, Canada; Institute of Cardiovascular Science, Soochow University, Suzhou 215008, China.
Wang G; Department of Pathology, University of Western Ontario, London, Ontario N6A 4G5, Canada.
Li S; Critical Illness Research, Lawson Health Research Institute, Canada; Department of Medicine, University of Western Ontario, London, Ontario N6A 4G5, Canada; Department of Pathology, University of Western Ontario, London, Ontario N6A 4G5, Canada.
Fan GC; Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati 45267, OH, USA.
Peng T; Institutes of Biology and Medical Science, Soochow University, Suzhou 215123, China; Critical Illness Research, Lawson Health Research Institute, Canada; Department of Medicine, University of Western Ontario, London, Ontario N6A 4G5, Canada; Department of Pathology, University of Western Ontario, London, Ontario N6A 4G5, Canada; Institute of Cardiovascular Science, Soochow University, Suzhou 215008, China. Electronic address: .
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Źródło :
Biochimica et biophysica acta [Biochim Biophys Acta] 2015 May; Vol. 1852 (5), pp. 882-92. Date of Electronic Publication: 2015 Feb 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*physiology
Calpain/*metabolism
Endoplasmic Reticulum Stress/*physiology
Myocytes, Cardiac/*metabolism
Animals ; Animals, Newborn ; Blotting, Western ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Calpain/genetics ; Cell Hypoxia ; Cell Line ; Cells, Cultured ; Enzyme Activation/drug effects ; Humans ; Mice, Inbred C57BL ; Mice, Transgenic ; Mitogen-Activated Protein Kinase 8/metabolism ; Mitogen-Activated Protein Kinase 9/metabolism ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/metabolism ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/drug effects ; Oxygen/pharmacology ; RNA Interference ; Rats
Czasopismo naukowe
Tytuł :
Hyperthermia Induces Apoptosis of 786-O Cells through Suppressing Ku80 Expression.
Autorzy :
Qi D; Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Provincial Key Laboratory of Urology, Guangzhou, China.
Hu Y; Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Provincial Key Laboratory of Urology, Guangzhou, China.
Li J; Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Provincial Key Laboratory of Urology, Guangzhou, China.
Peng T; Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Provincial Key Laboratory of Urology, Guangzhou, China.
Su J; Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Provincial Key Laboratory of Urology, Guangzhou, China.
He Y; School of public health, Sun Yat-sen University, Guangzhou, China.
Ji W; The center for translational medicine, The first affiliated hospital, Sun Yat-Sen University, Guangzhou, China.
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Źródło :
PloS one [PLoS One] 2015 Apr 22; Vol. 10 (4), pp. e0122977. Date of Electronic Publication: 2015 Apr 22 (Print Publication: 2015).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Gene Expression Regulation, Neoplastic*
Hyperthermia, Induced*
Antigens, Nuclear/*genetics
Carcinoma, Renal Cell/*pathology
DNA-Binding Proteins/*genetics
Kidney Neoplasms/*pathology
Cell Cycle ; Cell Line, Tumor ; Hot Temperature ; Humans ; Ku Autoantigen
Czasopismo naukowe
Tytuł :
Curcumol induces apoptosis in SPC-A-1 human lung adenocarcinoma cells and displays anti-neoplastic effects in tumor bearing mice.
Autorzy :
Tang QL; College of Chinese Medicine, Guangdong Pharmaceutical University, Guangdong, China E-mail : .
Guo JQ
Wang QY
Lin HS
Yang ZP
Peng T
Pan XD
Liu B
Wang SJ
Zang LQ
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Źródło :
Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2015; Vol. 16 (6), pp. 2307-12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*pathology
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Lung/*pathology
Lung Neoplasms/*pathology
Sesquiterpenes/*pharmacology
Adenocarcinoma/drug therapy ; Adenocarcinoma/metabolism ; Animals ; Blotting, Western ; Cell Cycle/drug effects ; Cells, Cultured ; Drugs, Chinese Herbal ; Flow Cytometry ; Humans ; Lung/drug effects ; Lung/metabolism ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
MicroRNA-9 regulates neural apoptosis in methylmalonic acidemia via targeting BCL2L11.
Autorzy :
Li Y; Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Peng T; Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Li L; Department of Neurology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450052, China.
Wang X; Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Duan R; Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Gao H; Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Guan W; Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Lu J; Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Teng J; Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Jia Y; Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. Electronic address: .
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Źródło :
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience [Int J Dev Neurosci] 2014 Aug; Vol. 36, pp. 19-24. Date of Electronic Publication: 2014 May 02.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Metabolism, Inborn Errors/*genetics
Amino Acid Metabolism, Inborn Errors/*pathology
Apoptosis/*genetics
Apoptosis Regulatory Proteins/*metabolism
Membrane Proteins/*metabolism
MicroRNAs/*metabolism
Neurons/*physiology
Proto-Oncogene Proteins/*metabolism
Animals ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/genetics ; Bcl-2-Like Protein 11 ; Cerebral Cortex/cytology ; Flow Cytometry ; In Situ Nick-End Labeling ; Membrane Proteins/genetics ; Methylmalonic Acid/pharmacology ; Mice ; Mice, Inbred BALB C ; MicroRNAs/genetics ; Proto-Oncogene Proteins/genetics ; Transfection
SCR Disease Name :
Methylmalonic acidemia
Czasopismo naukowe
Tytuł :
Coxsackievirus B3-induced calpain activation facilitates the progeny virus replication via a likely mechanism related with both autophagy enhancement and apoptosis inhibition in the early phase of infection: an in vitro study in H9c2 cells.
Autorzy :
Li M; Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China.
Wang X; Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China.
Yu Y; Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China.
Yu Y; Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China.
Xie Y; Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China.
Zou Y; Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China.
Ge J; Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China.
Peng T; Lawson Health Research Institute, Department of Medicine and Pathology, University of Western Ontario, Canada.
Chen R; Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China. Electronic address: .
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Źródło :
Virus research [Virus Res] 2014 Jan 22; Vol. 179, pp. 177-86. Date of Electronic Publication: 2013 Oct 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Autophagy*
Virus Replication*
Calpain/*metabolism
Coxsackievirus Infections/*enzymology
Coxsackievirus Infections/*virology
Enterovirus B, Human/*physiology
Calpain/genetics ; Cell Line ; Coxsackievirus Infections/physiopathology ; Enterovirus B, Human/genetics ; Enzyme Activation ; Humans ; Viral Proteins/genetics ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Clinical significance of proliferation, apoptosis and senescence of nasopharyngeal cells by the simultaneously blocking EGF, IGF-1 receptors and Bcl-xl genes.
Autorzy :
Dai G; Anatomy & Embryology, Wuhan University School of Medicine, Wuhan, Hubei 430071, PR China.
Peng T
Zhou X
Zhu J
Kong Z
Ma L
Xiong Z
Yuan Y
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2013 Nov 01; Vol. 440 (4), pp. 479-84. Date of Electronic Publication: 2013 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*genetics
Cellular Senescence/*genetics
ErbB Receptors/*antagonists & inhibitors
Nasopharyngeal Neoplasms/*pathology
Receptor, IGF Type 1/*antagonists & inhibitors
bcl-X Protein/*antagonists & inhibitors
Cell Line, Tumor ; Cell Proliferation ; ErbB Receptors/genetics ; Humans ; Nasopharyngeal Neoplasms/therapy ; RNA Interference ; Receptor, IGF Type 1/genetics ; bcl-X Protein/genetics
Czasopismo naukowe
Tytuł :
Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients.
Autorzy :
Han J; 1st Affiliated Hospital of Sun Yat-sen University, Pathology Department, Guangzhou 510080, PR China. />Tian R
Yong B
Luo C
Tan P
Shen J
Peng T
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2013 Jun 07; Vol. 435 (3), pp. 493-500. Date of Electronic Publication: 2013 May 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*physiology
Bone Neoplasms/*metabolism
Bone Neoplasms/*pathology
Intercellular Signaling Peptides and Proteins/*metabolism
Osteosarcoma/*metabolism
Osteosarcoma/*pathology
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
Adolescent ; Adult ; Cell Line, Tumor ; Cell Movement ; Child ; Female ; Humans ; Male ; Matrix Metalloproteinase 9/metabolism ; Middle Aged ; Neoplasm Invasiveness ; Osteosarcoma/secondary ; Prognosis ; Young Adult
Czasopismo naukowe
Tytuł :
Over-expression of calpastatin aggravates cardiotoxicity induced by doxorubicin.
Autorzy :
Wang Y; Department of Cardiology, Shanghai 6th People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200233, China.
Zheng D
Wei M
Ma J
Yu Y
Chen R
Lacefield JC
Xu H
Peng T
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Źródło :
Cardiovascular research [Cardiovasc Res] 2013 Jun 01; Vol. 98 (3), pp. 381-90. Date of Electronic Publication: 2013 Mar 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibiotics, Antineoplastic/*toxicity
Apoptosis/*drug effects
Calcium-Binding Proteins/*metabolism
Doxorubicin/*toxicity
Heart Diseases/*metabolism
Myocytes, Cardiac/*drug effects
Animals ; Calcium-Binding Proteins/genetics ; Calpain/antagonists & inhibitors ; Calpain/genetics ; Calpain/metabolism ; Cells, Cultured ; Cysteine Proteinase Inhibitors/pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Glycogen Synthase Kinase 3/metabolism ; Glycogen Synthase Kinase 3 beta ; Heart Diseases/chemically induced ; Heart Diseases/diagnostic imaging ; Heart Diseases/genetics ; Heart Diseases/pathology ; Heart Diseases/physiopathology ; Hemodynamics/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Messenger/metabolism ; Time Factors ; Transfection ; Ultrasonography ; Up-Regulation ; Ventricular Function, Left/drug effects
Czasopismo naukowe
Tytuł :
Proliferative and apoptotic effects of andrographolide on the BGC-823 human gastric cancer cell line.
Autorzy :
Li SG; Department of Gastrointestinal Surgery, the First Affiliated Hospital, Hebei North University, Zhangjiakou, Hebei 075000, China.
Wang YY
Ye ZY
Shao QS
Tao HQ
Shu LS
Zhao YF
Yang YJ
Yang J
Peng T
Han B
Huang D
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Źródło :
Chinese medical journal [Chin Med J (Engl)] 2013; Vol. 126 (19), pp. 3739-44.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Diterpenes/*pharmacology
Stomach Neoplasms/*drug therapy
Caspase 3/analysis ; Caspase 3/genetics ; Cell Cycle/drug effects ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Humans ; Proto-Oncogene Proteins c-bcl-2/analysis ; Stomach Neoplasms/pathology ; bcl-2-Associated X Protein/analysis ; bcl-2-Associated X Protein/genetics
Czasopismo naukowe

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