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Tytuł :
Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.
Autorzy :
Khawaja AP; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Cooke Bailey JN; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Simcoe M; Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK.; Department of Twin Research & Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK.
Igo RP Jr; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Song YE; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Wojciechowski R; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Johns Hopkins Wilmer Eye Institute, Baltimore, MD, USA.
Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye-ACP), Duke-NUS Medical School, Singapore, Singapore.
Khaw PT; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
Pasquale LR; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
Haines JL; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Foster PJ; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.; Division of Genetics and Epidemiology, UCL Institute of Ophthalmology, London, UK.
Wiggs JL; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA. .
Hammond CJ; Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK. .
Hysi PG; Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK. .; Department of Twin Research & Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK. .
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Corporate Authors :
UK Biobank Eye and Vision Consortium
NEIGHBORHOOD Consortium
Źródło :
Nature genetics [Nat Genet] 2018 Jun; Vol. 50 (6), pp. 778-782. Date of Electronic Publication: 2018 May 21.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Loci/*genetics
Genetic Predisposition to Disease/*genetics
Glaucoma, Open-Angle/*genetics
Intraocular Pressure/*genetics
Adult ; Aged ; Cohort Studies ; Female ; Genome-Wide Association Study/methods ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Risk Factors
Czasopismo naukowe
Tytuł :
Associations with Intraocular Pressure in a Large Cohort: Results from the UK Biobank.
Autorzy :
Chan MP; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.
Grossi CM; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.
Khawaja AP; Department of Public Health & Primary Care, University of Cambridge, Cambridge, United Kingdom.
Yip JL; Department of Public Health & Primary Care, University of Cambridge, Cambridge, United Kingdom.
Khaw KT; Department of Public Health & Primary Care, University of Cambridge, Cambridge, United Kingdom.
Patel PJ; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.
Khaw PT; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.
Morgan JE; School of Optometry & Vision Sciences, Cardiff University, Cardiff, United Kingdom.
Vernon SA; Department of Ophthalmology, Nottingham University Hospital NHS Trust, Nottingham, United Kingdom.
Foster PJ; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom. Electronic address: .
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Corporate Authors :
UK Biobank Eye and Vision Consortium
Źródło :
Ophthalmology [Ophthalmology] 2016 Apr; Vol. 123 (4), pp. 771-82. Date of Electronic Publication: 2016 Jan 13.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Tonometry, Ocular*
Cornea/*physiology
Intraocular Pressure/*physiology
Adult ; Aged ; Aging/physiology ; Blood Pressure/physiology ; Body Mass Index ; Cohort Studies ; Cross-Sectional Studies ; Databases, Factual ; Female ; Heart Rate/physiology ; Humans ; Male ; Middle Aged ; National Health Programs ; Prospective Studies ; Refraction, Ocular/physiology ; Surveys and Questionnaires ; United Kingdom
Czasopismo naukowe
Tytuł :
Impact of age, diagnosis, and history of glaucoma surgery on outcomes in pediatric patients treated with latanoprost.
Autorzy :
Maeda-Chubachi T; Pfizer Inc., New London, CT †Pfizer Inc., La Jolla, CA ‡Private Practice, Jupiter, FL §Pediatric Ophthalmology Department, University Hospital of Amiens, INSERM UMRS 968, France ∥Duke Eye Center, Durham, NC ¶NIHR Biomedical Research Centre, Moorfields Eye Hospital & UCL Institute of Ophthalmology, London, United Kingdom #Moran Eye Center, University of Utah, Salt Lake City, UT.
Chi-Burris K
Simons B
Brémond-Gignac D
Freedman S
Khaw PT
Wirostko B
Yan E
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Corporate Authors :
A6111137 Study Group
Źródło :
Journal of glaucoma [J Glaucoma] 2013 Oct-Nov; Vol. 22 (8), pp. 614-9.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Antihypertensive Agents/*therapeutic use
Filtering Surgery/*statistics & numerical data
Glaucoma, Open-Angle/*diagnosis
Hydrophthalmos/*diagnosis
Intraocular Pressure/*drug effects
Prostaglandins F, Synthetic/*therapeutic use
Adolescent ; Age Factors ; Antihypertensive Agents/adverse effects ; Child ; Child, Preschool ; Double-Blind Method ; Female ; Glaucoma, Open-Angle/drug therapy ; Humans ; Hydrophthalmos/drug therapy ; Infant ; Latanoprost ; Male ; Prospective Studies ; Prostaglandins F, Synthetic/adverse effects ; Timolol/adverse effects ; Timolol/therapeutic use ; Tonometry, Ocular
Czasopismo naukowe
Tytuł :
Cataract surgery after trabeculectomy: the effect on trabeculectomy function.
Autorzy :
Husain R; Singapore National Eye Center, Singapore.
Liang S
Foster PJ
Gazzard G
Bunce C
Chew PT
Oen FT
Khaw PT
Seah SK
Aung T
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Źródło :
Archives of ophthalmology (Chicago, Ill. : 1960) [Arch Ophthalmol] 2012 Feb; Vol. 130 (2), pp. 165-70. Date of Electronic Publication: 2011 Oct 10.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Phacoemulsification*
Trabeculectomy*
Glaucoma, Angle-Closure/*surgery
Glaucoma, Open-Angle/*surgery
Intraocular Pressure/*physiology
Adult ; Aged ; Aged, 80 and over ; Alkylating Agents/administration & dosage ; Female ; Fluorouracil/administration & dosage ; Follow-Up Studies ; Glaucoma, Angle-Closure/physiopathology ; Glaucoma, Open-Angle/physiopathology ; Gonioscopy ; Humans ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Time Factors ; Treatment Failure ; Treatment Outcome ; Visual Acuity/physiology ; Visual Fields/physiology
Czasopismo naukowe
Tytuł :
Structural basis of glaucoma: the fortified astrocytes of the optic nerve head are the target of raised intraocular pressure.
Autorzy :
Dai C; Spinal Repair Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London WC1N 3BG, UK.
Khaw PT
Yin ZQ
Li D
Raisman G
Li Y
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Źródło :
Glia [Glia] 2012 Jan; Vol. 60 (1), pp. 13-28. Date of Electronic Publication: 2011 Sep 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Stress, Physiological*
Astrocytes/*pathology
Glaucoma/*pathology
Intraocular Pressure/*physiology
Optic Disk/*pathology
Optic Nerve Diseases/*physiopathology
Animals ; Astrocytes/ultrastructure ; Axons/pathology ; Axons/ultrastructure ; Disease Models, Animal ; Female ; Glaucoma/physiopathology ; Microscopy, Electron, Transmission ; Rats ; Retinal Ganglion Cells/pathology ; Time Factors
Czasopismo naukowe
Tytuł :
Comparison of latanoprost and timolol in pediatric glaucoma: a phase 3, 12-week, randomized, double-masked multicenter study.
Autorzy :
Maeda-Chubachi T; Pfizer Inc, New London, Connecticut, USA.
Chi-Burris K
Simons BD
Freedman SF
Khaw PT
Wirostko B
Yan E
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Corporate Authors :
A6111137 Study Group
Źródło :
Ophthalmology [Ophthalmology] 2011 Oct; Vol. 118 (10), pp. 2014-21. Date of Electronic Publication: 2011 Jun 16.
Typ publikacji :
Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Antihypertensive Agents/*administration & dosage
Glaucoma/*drug therapy
Hydrophthalmos/*drug therapy
Intraocular Pressure/*drug effects
Prostaglandins F, Synthetic/*administration & dosage
Timolol/*administration & dosage
Adolescent ; Antihypertensive Agents/adverse effects ; Child ; Child, Preschool ; Double-Blind Method ; Female ; Glaucoma/physiopathology ; Humans ; Hydrophthalmos/physiopathology ; Infant ; Latanoprost ; Male ; Ophthalmic Solutions/administration & dosage ; Ophthalmic Solutions/adverse effects ; Prospective Studies ; Prostaglandins F, Synthetic/adverse effects ; Time Factors ; Timolol/adverse effects ; Tonometry, Ocular ; Treatment Outcome
Czasopismo naukowe
Tytuł :
The singapore 5-Fluorouracil trabeculectomy study: effects on intraocular pressure control and disease progression at 3 years.
Autorzy :
Wong TT; Singapore National Eye Center, Singapore and Singapore Eye Research Institute, Singapore. />Khaw PT
Aung T
Foster PJ
Htoon HM
Oen FT
Gazzard G
Husain R
Devereux JG
Minassian D
Tan SB
Chew PT
Seah SK
Pokaż więcej
Źródło :
Ophthalmology [Ophthalmology] 2009 Feb; Vol. 116 (2), pp. 175-84.
Typ publikacji :
Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Trabeculectomy*
Antimetabolites, Antineoplastic/*administration & dosage
Fluorouracil/*administration & dosage
Glaucoma, Angle-Closure/*therapy
Glaucoma, Open-Angle/*therapy
Intraocular Pressure/*physiology
Adult ; Aged ; Combined Modality Therapy ; Disease Progression ; Double-Blind Method ; Female ; Follow-Up Studies ; Glaucoma, Angle-Closure/drug therapy ; Glaucoma, Angle-Closure/physiopathology ; Glaucoma, Angle-Closure/surgery ; Glaucoma, Open-Angle/drug therapy ; Glaucoma, Open-Angle/physiopathology ; Glaucoma, Open-Angle/surgery ; Humans ; Intraoperative Care ; Male ; Middle Aged ; Optic Disk/pathology ; Prospective Studies ; Risk ; Singapore ; Visual Fields
Czasopismo naukowe
Tytuł :
Failure of medical therapy despite normal intraocular pressure.
Autorzy :
Walland MJ; Department of Ophthalmology, Royal Melbourne Hospital, Melbourne, Australia. />Carassa RG
Goldberg I
Grehn F
Heuer DK
Khaw PT
Thomas R
Parikh R
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Źródło :
Clinical & experimental ophthalmology [Clin Exp Ophthalmol] 2006 Dec; Vol. 34 (9), pp. 827-36.
Typ publikacji :
Case Reports; Consensus Development Conference; Journal Article
MeSH Terms :
Antihypertensive Agents/*therapeutic use
Glaucoma, Open-Angle/*drug therapy
Intraocular Pressure/*physiology
Adult ; Cataract/complications ; Contact Lenses ; Disease Progression ; Drug Therapy, Combination ; Female ; Glaucoma, Open-Angle/surgery ; Humans ; Male ; Middle Aged ; Myopia/complications ; Practice Guidelines as Topic ; Trabeculectomy/methods ; Treatment Failure ; Uveitis/complications ; Vision Disorders/prevention & control ; Visual Fields
Czasopismo naukowe
Tytuł :
Accuracy of intraocular pressure measurements in new zealand white rabbits.
Autorzy :
Lim KS; Glaucoma Service, Moorfields Eye Hospital, London, UK. />Wickremasinghe SS
Cordeiro MF
Bunce C
Khaw PT
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2005 Jul; Vol. 46 (7), pp. 2419-23.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Intraocular Pressure*
Tonometry, Ocular/*standards
Animals ; Rabbits ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Flap and suture manipulation after trabeculectomy with adjustable sutures: titration of flow and intraocular pressure in guarded filtration surgery.
Autorzy :
Wells AP; Wound Healing Research Unit, Institute of Ophthalmology and Moorfields Eye Hospital, London. />Bunce C
Khaw PT
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Źródło :
Journal of glaucoma [J Glaucoma] 2004 Oct; Vol. 13 (5), pp. 400-6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Intraocular Pressure*
Rheology*
Surgical Flaps*
Suture Techniques*
Trabeculectomy*
Equipment Design ; Humans ; Sutures ; Tissue Donors
Czasopismo naukowe
Tytuł :
Determinants of intraocular pressure and its association with glaucomatous optic neuropathy in Chinese Singaporeans: the Tanjong Pagar Study.
Autorzy :
Foster PJ; Singapore National Eye Centre and Singapore Eye Research Institute, Singapore.
Machin D
Wong TY
Ng TP
Kirwan JF
Johnson GJ
Khaw PT
Seah SK
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2003 Sep; Vol. 44 (9), pp. 3885-91.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glaucoma/*physiopathology
Intraocular Pressure/*physiology
Optic Nerve/*pathology
Optic Nerve Diseases/*physiopathology
Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group ; Blood Pressure ; Cornea/anatomy & histology ; Female ; Glaucoma/diagnosis ; Glaucoma/ethnology ; Gonioscopy ; Humans ; Male ; Middle Aged ; Optic Nerve Diseases/diagnosis ; Optic Nerve Diseases/ethnology ; Singapore/epidemiology ; Tonometry, Ocular ; Visual Field Tests ; Visual Fields
Czasopismo naukowe
Tytuł :
The corneal thickness and intraocular pressure story: where are we now?
Autorzy :
Lee GA; City Eye Centre, Brisbane, Queensland, Australia. />Khaw PT
Ficker LA
Shah P
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Źródło :
Clinical & experimental ophthalmology [Clin Exp Ophthalmol] 2002 Oct; Vol. 30 (5), pp. 334-7.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Intraocular Pressure*
Photorefractive Keratectomy*
Cornea/*pathology
Glaucoma, Open-Angle/*diagnosis
Cornea/surgery ; Humans ; Lasers, Excimer ; Myopia/surgery ; Ocular Hypertension/diagnosis ; Tonometry, Ocular
Czasopismo naukowe
Tytuł :
[The experimental studies of the effect of Forskolin on the lowering of intraocular pressure].
Autorzy :
Peng T; Zhongshan Ophthalmic Center, Sun Yat-Sen University of Medical Sciences, Guangzhou, China.
Chen X
Zhou W
Zeng S
Shen B
Wen L
Hu B
Liu C
Yao W
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Źródło :
Yan ke xue bao = Eye science [Yan Ke Xue Bao] 1992 Dec; Vol. 8 (4), pp. 152-5.
Typ publikacji :
English Abstract; Journal Article
MeSH Terms :
Colforsin/*pharmacology
Intraocular Pressure/*drug effects
Ocular Hypertension/*drug therapy
Adenylyl Cyclases/metabolism ; Animals ; Colforsin/therapeutic use ; Male ; Ocular Hypertension/enzymology ; Ophthalmic Solutions ; Rabbits
Czasopismo naukowe
Tytuł :
Longitudinal changes in anterior chamber depth and axial length in Asian subjects after trabeculectomy surgery.
Autorzy :
Husain, Rahat
Wen Li
Gazzard, Gus
Foster, Paul J.
Chew, Paul T.
Oen, Francis T.
Phillips, Rachel
Khaw, Peng T.
Seah, Steve K.
Aung, Tin
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Temat :
ANTERIOR chamber (Eye)
GLAUCOMA surgery
INTRAOCULAR pressure
COHORT analysis
ANGLE-closure glaucoma
ASIANS
Źródło :
British Journal of Ophthalmology; Jul2013, Vol. 97 Issue 7, p852-856, 5p
Czasopismo naukowe

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