Temat: "Peptide Chain Elongation, Translational" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Emerging Personalized Opportunities for Enhancing Translational Readthrough in Rare Genetic Diseases and Beyond.
Autorzy:: Wagner RN; Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.
Wießner M; Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.
Friedrich A; Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.; Department of Biosciences, University of Salzburg, 5020 Salzburg, Austria.
Zandanell J; Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.
Breitenbach-Koller H; Department of Biosciences, University of Salzburg, 5020 Salzburg, Austria.
Bauer JW; Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 23; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 23.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Codon, Nonsense*/genetics
Genetic Diseases, Inborn*/genetics
Genetic Diseases, Inborn*/therapy
Peptide Chain Elongation, Translational*/drug effects
Precision Medicine*/methods
Precision Medicine*/trends
Rare Diseases*/genetics
Rare Diseases*/therapy
Suppression, Genetic*/drug effects
Suppression, Genetic*/genetics
Animals ; Humans ; Breast Neoplasms/genetics ; Breast Neoplasms/therapy ; Cystic Fibrosis/genetics ; Cystic Fibrosis/therapy ; Epidermolysis Bullosa/genetics ; Epidermolysis Bullosa/therapy ; Nephritis, Hereditary/genetics ; Nephritis, Hereditary/therapy ; Nonsense Mediated mRNA Decay ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/therapy ; Shwachman-Diamond Syndrome/genetics ; Shwachman-Diamond Syndrome/therapy ; Peptide Chain Termination, Translational/drug effects ; Aminoglycosides/pharmacology

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Skocz do pozycji: 2.

Tytuł:: Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon.
Autorzy:: Hilal T; Institut für Medizinische Physik und Biophysik, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Killam BY; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Grozdanović M; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Dobosz-Bartoszek M; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Loerke J; Institut für Medizinische Physik und Biophysik, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Bürger J; Institut für Medizinische Physik und Biophysik, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Max-Planck Institut für Molekulare Genetik, 14195 Berlin, Germany.
Mielke T; Max-Planck Institut für Molekulare Genetik, 14195 Berlin, Germany.
Copeland PR; Department of Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Simonović M; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Spahn CMT; Institut für Medizinische Physik und Biophysik, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Jun 17; Vol. 376 (6599), pp. 1338-1343. Date of Electronic Publication: 2022 Jun 16.
Typ publikacji:: Journal Article
MeSH Terms:: Codon, Terminator*/genetics
Peptide Chain Elongation, Translational*/genetics
RNA-Binding Proteins*/chemistry
RNA-Binding Proteins*/genetics
Ribosomes*/chemistry
Selenocysteine*/chemistry
Selenocysteine*/genetics
Selenocysteine*/metabolism
Selenoproteins*/biosynthesis
Selenoproteins*/genetics
Cryoelectron Microscopy ; Humans ; Protein Conformation

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Skocz do pozycji: 3.

Tytuł:: Peptidyl transferase center decompaction and structural constraints during early protein elongation on the ribosome.
Autorzy:: Jia B; Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Wang T; Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China. w_.
Lehmann J; CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), University of Paris-Saclay, 91198, Gif-sur-Yvette, France. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Dec 15; Vol. 11 (1), pp. 24061. Date of Electronic Publication: 2021 Dec 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Models, Molecular*
Peptide Chain Elongation, Translational*
Protein Conformation*
Peptidyl Transferases/*chemistry
Peptidyl Transferases/*metabolism
Ribosomes/*metabolism
Amino Acids/chemistry ; Binding Sites ; Peptides/chemistry ; Peptides/metabolism ; Protein Binding ; Protein Biosynthesis ; Structure-Activity Relationship

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Skocz do pozycji: 4.

Tytuł:: Differential Contribution of Protein Factors and 70S Ribosome to Elongation.
Autorzy:: Paleskava A; Petersburg Nuclear Physics Institute, NRC 'Kurchatov Institute', 188300 Gatchina, Russia.; Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.
Maksimova EM; Petersburg Nuclear Physics Institute, NRC 'Kurchatov Institute', 188300 Gatchina, Russia.
Vinogradova DS; Petersburg Nuclear Physics Institute, NRC 'Kurchatov Institute', 188300 Gatchina, Russia.
Kasatsky PS; Petersburg Nuclear Physics Institute, NRC 'Kurchatov Institute', 188300 Gatchina, Russia.
Kirillov SV; Petersburg Nuclear Physics Institute, NRC 'Kurchatov Institute', 188300 Gatchina, Russia.
Konevega AL; Petersburg Nuclear Physics Institute, NRC 'Kurchatov Institute', 188300 Gatchina, Russia.; Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.; NRC 'Kurchatov Institute', 123182 Moscow, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Sep 05; Vol. 22 (17). Date of Electronic Publication: 2021 Sep 05.
Typ publikacji:: Journal Article
MeSH Terms:: Peptide Chain Elongation, Translational*
Thermus thermophilus*
Bacterial Proteins/*metabolism
Escherichia coli/*metabolism
Peptide Elongation Factor Tu/*metabolism
Ribosomes/*metabolism
Peptide Elongation Factor G/metabolism ; RNA, Bacterial/metabolism ; RNA, Transfer/metabolism

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Skocz do pozycji: 5.

Tytuł:: Proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria.
Autorzy:: Krafczyk R; Department of Biology I, Microbiology, Ludwig-Maximilians-Universität München, München, Germany.
Qi F; Institute of Genomics, School of Biomedical Sciences, Huaqiao University, Xiamen, China.; Department of Bioinformatics, Wissenschaftzentrum Weihenstephan, Technische Universität München, Freising, Germany.
Sieber A; Department of Biology I, Microbiology, Ludwig-Maximilians-Universität München, München, Germany.
Mehler J; Department of Biology I, Microbiology, Ludwig-Maximilians-Universität München, München, Germany.
Jung K; Department of Biology I, Microbiology, Ludwig-Maximilians-Universität München, München, Germany.
Frishman D; Department of Bioinformatics, Wissenschaftzentrum Weihenstephan, Technische Universität München, Freising, Germany. .
Lassak J; Department of Biology I, Microbiology, Ludwig-Maximilians-Universität München, München, Germany. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2021 May 17; Vol. 4 (1), pp. 589. Date of Electronic Publication: 2021 May 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Codon*
Peptide Chain Elongation, Translational*
Protein Biosynthesis*
Selection, Genetic*
Escherichia coli/*genetics
Proline/*genetics
RNA, Transfer, Pro/*genetics
Ribosomes/*physiology
Escherichia coli/growth & development ; Escherichia coli/metabolism

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Skocz do pozycji: 6.

Tytuł:: "Protein aggregates" contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation.
Autorzy:: Shmookler Reis RJ; Central Arkansas Veterans Healthcare System, Little Rock, AR, USA.; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; BioInformatics Program, University of Arkansas for Medical Sciences and University of Arkansas at Little Rock, Little Rock, AR, USA.
Atluri R; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Balasubramaniam M; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Johnson J; BioInformatics Program, University of Arkansas for Medical Sciences and University of Arkansas at Little Rock, Little Rock, AR, USA.
Ganne A; BioInformatics Program, University of Arkansas for Medical Sciences and University of Arkansas at Little Rock, Little Rock, AR, USA.
Ayyadevara S; Central Arkansas Veterans Healthcare System, Little Rock, AR, USA.; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Pokaż więcej
Źródło:: Aging cell [Aging Cell] 2021 May; Vol. 20 (5), pp. e13326. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Peptide Chain Elongation, Translational*
Protein Aggregates*
DNA/*metabolism
RNA/*metabolism
Alzheimer Disease/metabolism ; Chromatin Immunoprecipitation Sequencing ; DNA-Binding Proteins/metabolism ; Glioma/metabolism ; Hippocampus/metabolism ; Humans ; Protein Folding ; RNA, Viral/metabolism ; RNA-Binding Proteins/metabolism ; RNA-Seq

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Skocz do pozycji: 7.

Tytuł:: Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA.
Autorzy:: Ormsby AR; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia.
Cox D; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia.
Daly J; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia.
Priest D; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia.
Hinde E; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia.
Hatters DM; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Jul 31; Vol. 15 (7), pp. e0233583. Date of Electronic Publication: 2020 Jul 31 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Peptide Chain Elongation, Translational*
Exons/*genetics
Huntingtin Protein/*genetics
Protein Aggregates/*genetics
RNA, Messenger/*genetics
Ribosomes/*metabolism
Base Sequence ; Epithelial Cells ; Genes, Reporter ; HEK293 Cells ; Humans ; Huntingtin Protein/biosynthesis ; Inclusion Bodies/genetics ; Inclusion Bodies/metabolism ; Minisatellite Repeats ; Peptides ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism

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Skocz do pozycji: 8.

Tytuł:: In-cell architecture of an actively transcribing-translating expressome.
Autorzy:: O'Reilly FJ; Bioanalytics Unit, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany.
Xue L; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.; Collaboration for joint PhD degree between EMBL and Heidelberg University, Faculty of Biosciences, 69120 Heidelberg, Germany.
Graziadei A; Bioanalytics Unit, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany.
Sinn L; Bioanalytics Unit, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany.
Lenz S; Bioanalytics Unit, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany.
Tegunov D; Department of Molecular Biology, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
Blötz C; Department of General Microbiology, Institute of Microbiology and Genetics, GZMB, Georg-August-University Göttingen, 37077 Göttingen, Germany.
Singh N; Department of General Microbiology, Institute of Microbiology and Genetics, GZMB, Georg-August-University Göttingen, 37077 Göttingen, Germany.
Hagen WJH; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
Cramer P; Department of Molecular Biology, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
Stülke J; Department of General Microbiology, Institute of Microbiology and Genetics, GZMB, Georg-August-University Göttingen, 37077 Göttingen, Germany.
Mahamid J; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany. .
Rappsilber J; Bioanalytics Unit, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany. .; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2020 Jul 31; Vol. 369 (6503), pp. 554-557.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Peptide Chain Elongation, Translational*
Protein Interaction Maps*
Transcription, Genetic*
Mycoplasma pneumoniae/*metabolism
Mycoplasma pneumoniae/*ultrastructure
Bacterial Proteins/metabolism ; DNA-Directed RNA Polymerases/metabolism ; Genome, Bacterial ; Humans ; Mycoplasma pneumoniae/genetics ; Peptide Elongation Factors/metabolism ; Ribosomes/metabolism ; Transcriptome

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Skocz do pozycji: 9.

Tytuł:: Reconstitution of yeast translation elongation and termination in vitro utilizing CrPV IRES-containing mRNA.
Autorzy:: Abe T; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5, Kashiwanoha, Kashiwa-shi, Chiba 277-8562, Japan.
Nagai R; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5, Kashiwanoha, Kashiwa-shi, Chiba 277-8562, Japan.
Imataka H; Department of Materials Science and Chemistry, Graduate School of Engineering, University of Hyogo, Himeji 671-2201, Japan.
Takeuchi-Tomita N; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5, Kashiwanoha, Kashiwa-shi, Chiba 277-8562, Japan.; Pokaż więcej
Źródło:: Journal of biochemistry [J Biochem] 2020 May 01; Vol. 167 (5), pp. 441-450.
Typ publikacji:: Journal Article
MeSH Terms:: Peptide Chain Elongation, Translational*
Peptide Chain Termination, Translational*
Peptides/*metabolism
RNA, Messenger/*metabolism
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae/*metabolism

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Skocz do pozycji: 10.

Tytuł:: The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Autorzy:: Buschauer R; Gene Center and Department of Biochemistry, University of Munich, 81377 Munich, Germany.
Matsuo Y; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Sugiyama T; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Chen YH; Center for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Alhusaini N; Center for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Sweet T; Center for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Ikeuchi K; Gene Center and Department of Biochemistry, University of Munich, 81377 Munich, Germany.; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Cheng J; Gene Center and Department of Biochemistry, University of Munich, 81377 Munich, Germany.
Matsuki Y; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Nobuta R; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Gilmozzi A; Gene Center and Department of Biochemistry, University of Munich, 81377 Munich, Germany.
Berninghausen O; Gene Center and Department of Biochemistry, University of Munich, 81377 Munich, Germany.
Tesina P; Gene Center and Department of Biochemistry, University of Munich, 81377 Munich, Germany.
Becker T; Gene Center and Department of Biochemistry, University of Munich, 81377 Munich, Germany.
Coller J; Center for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. .
Inada T; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan. .
Beckmann R; Gene Center and Department of Biochemistry, University of Munich, 81377 Munich, Germany. .; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2020 Apr 17; Vol. 368 (6488).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Codon*
Peptide Chain Elongation, Translational*
RNA Stability*
Repressor Proteins/*metabolism
Ribonucleases/*metabolism
Ribosomes/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Transcription Factors/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Cryoelectron Microscopy ; Multiprotein Complexes/chemistry ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Peptide Initiation Factors/metabolism ; Protein Conformation, alpha-Helical ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism ; Repressor Proteins/chemistry ; Repressor Proteins/genetics ; Ribonucleases/chemistry ; Ribonucleases/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination ; Eukaryotic Translation Initiation Factor 5A

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Skocz do pozycji: 11.

Tytuł:: A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data.
Autorzy:: Sharma AK; Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States of America.
Sormanni P; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
Ahmed N; Bioinformatics and Genomics Graduate Program, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, United States of America.
Ciryam P; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
Friedrich UA; Center for Molecular Biology of the Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kramer G; Center for Molecular Biology of the Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
O'Brien EP; Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States of America.; Bioinformatics and Genomics Graduate Program, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, United States of America.; Institute for CyberScience, Pennsylvania State University, University Park, Pennsylvania, United States of America.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2019 May 23; Vol. 15 (5), pp. e1007070. Date of Electronic Publication: 2019 May 23 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Peptide Chain Elongation, Translational*
Peptide Chain Initiation, Translational*
Animals ; Codon/genetics ; Codon/metabolism ; Computational Biology ; Computer Simulation ; Kinetics ; Mice ; Models, Biological ; Mouse Embryonic Stem Cells/metabolism ; Nucleic Acid Conformation ; RNA Caps/chemistry ; RNA Caps/genetics ; RNA Caps/metabolism ; RNA, Fungal/chemistry ; RNA, Fungal/genetics ; RNA, Fungal/metabolism ; Ribosomes/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Transcriptome

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Skocz do pozycji: 12.

Tytuł:: Novel insights into gene expression regulation during meiosis revealed by translation elongation dynamics.
Autorzy:: Sabi R; 1Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel.
Tuller T; 1Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel.; 2The Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.; Pokaż więcej
Źródło:: NPJ systems biology and applications [NPJ Syst Biol Appl] 2019 Apr 04; Vol. 5, pp. 12. Date of Electronic Publication: 2019 Apr 04 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation/*genetics
Meiosis/*genetics
Peptide Chain Elongation, Translational/*genetics
Computational Biology/methods ; Peptide Chain Elongation, Translational/physiology ; Peptide Chain Initiation, Translational/genetics ; Peptide Chain Initiation, Translational/physiology ; RNA, Messenger/genetics ; Ribosomal Proteins/genetics ; Ribosomes/genetics ; Saccharomyces cerevisiae/genetics

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Skocz do pozycji: 13.

Tytuł:: Evolutionary analysis of polyproline motifs in Escherichia coli reveals their regulatory role in translation.
Autorzy:: Qi F; Department of Bioinformatics, Wissenschaftzentrum Weihenstephan, Technische Universität München, Freising, Germany.
Motz M; Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Munich, Germany.; Department of Biology I, Microbiology, Ludwig-Maximilians-Universität München, Martinsried, Germany.
Jung K; Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Munich, Germany.; Department of Biology I, Microbiology, Ludwig-Maximilians-Universität München, Martinsried, Germany.
Lassak J; Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Munich, Germany.; Department of Biology I, Microbiology, Ludwig-Maximilians-Universität München, Martinsried, Germany.
Frishman D; Department of Bioinformatics, Wissenschaftzentrum Weihenstephan, Technische Universität München, Freising, Germany.; St Petersburg State Polytechnic University, St Petersburg, Russia.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2018 Feb 01; Vol. 14 (2), pp. e1005987. Date of Electronic Publication: 2018 Feb 01 (Print Publication: 2018).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Amino Acid Motifs*
Peptide Chain Elongation, Translational*
Protein Biosynthesis*
Escherichia coli/*metabolism
Peptides/*chemistry
Escherichia coli Proteins/metabolism ; Evolution, Molecular ; Peptide Elongation Factors/metabolism ; Phylogeny ; Protein Folding ; Proteome/metabolism ; Proteomics ; Ribosomes/metabolism

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Skocz do pozycji: 14.

Tytuł:: The expression profile and prognostic significance of eukaryotic translation elongation factors in different cancers.
Autorzy:: Hassan MK; School of Biological Sciences, National Institute of Science Education and Research, HBNI, Bhimpur- Padanpur, Jatni, Khurda, Odisha, India.
Kumar D; School of Biological Sciences, National Institute of Science Education and Research, HBNI, Bhimpur- Padanpur, Jatni, Khurda, Odisha, India.
Naik M; School of Biological Sciences, National Institute of Science Education and Research, HBNI, Bhimpur- Padanpur, Jatni, Khurda, Odisha, India.
Dixit M; School of Biological Sciences, National Institute of Science Education and Research, HBNI, Bhimpur- Padanpur, Jatni, Khurda, Odisha, India.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2018 Jan 17; Vol. 13 (1), pp. e0191377. Date of Electronic Publication: 2018 Jan 17 (Print Publication: 2018).
Typ publikacji:: Journal Article
MeSH Terms:: Neoplasms/*genetics
Peptide Chain Elongation, Translational/*genetics
Transcriptome/*genetics
Cell Transformation, Neoplastic ; Databases, Nucleic Acid ; Humans ; Kaplan-Meier Estimate ; Peptide Chain Elongation, Translational/physiology ; Peptide Elongation Factor 1/genetics ; Peptide Elongation Factor 1/metabolism ; Prognosis ; Protein Biosynthesis ; Protein Isoforms/metabolism

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Skocz do pozycji: 15.

Tytuł:: The impact of ribosomal interference, codon usage, and exit tunnel interactions on translation elongation rate variation.
Autorzy:: Dao Duc K; Computer Science Division, University of California Berkeley, Berkeley, California, United States of America.
Song YS; Computer Science Division, University of California Berkeley, Berkeley, California, United States of America.; Department of Statistics, University of California Berkeley, Berkeley, California, United States of America.; Chan Zuckerberg Biohub, San Francisco, California, United States of America.; Pokaż więcej
Źródło:: PLoS genetics [PLoS Genet] 2018 Jan 16; Vol. 14 (1), pp. e1007166. Date of Electronic Publication: 2018 Jan 16 (Print Publication: 2018).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Peptide Chain Elongation, Translational*
Codon/*metabolism
Ribosomes/*metabolism
Animals ; Datasets as Topic ; Humans ; Peptides/genetics ; Peptides/metabolism ; Protein Binding ; Protein Biosynthesis/physiology ; Protein Interaction Domains and Motifs ; Ribosomes/chemistry ; Ribosomes/physiology ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism

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Skocz do pozycji: 16.

Tytuł:: Comprehensive characterization of a theophylline riboswitch reveals two pivotal features of Shine-Dalgarno influencing activated translation property.
Autorzy:: Cui W; School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China.; Key Laboratory of Industrial Biotechnology (Ministry of Education), Jiangnan University, Wuxi, Jiangsu, China.
Cheng J; School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China.
Miao S; School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China.
Zhou L; School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China.; Key Laboratory of Industrial Biotechnology (Ministry of Education), Jiangnan University, Wuxi, Jiangsu, China.
Liu Z; School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China.; Key Laboratory of Industrial Biotechnology (Ministry of Education), Jiangnan University, Wuxi, Jiangsu, China.
Guo J; School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China.; Key Laboratory of Industrial Biotechnology (Ministry of Education), Jiangnan University, Wuxi, Jiangsu, China.
Zhou Z; School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China. .; Key Laboratory of Industrial Biotechnology (Ministry of Education), Jiangnan University, Wuxi, Jiangsu, China. .; Pokaż więcej
Źródło:: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2017 Mar; Vol. 101 (5), pp. 2107-2120. Date of Electronic Publication: 2016 Dec 16.
Typ publikacji:: Journal Article
MeSH Terms:: Bacillus subtilis/*genetics
Gene Expression Regulation, Bacterial/*drug effects
Peptide Chain Elongation, Translational/*drug effects
Riboswitch/*drug effects
Theophylline/*pharmacology
Bacterial Proteins/genetics ; Base Sequence/genetics ; Codon, Initiator/genetics ; Peptide Chain Elongation, Translational/genetics ; Promoter Regions, Genetic/genetics ; Riboswitch/genetics

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Skocz do pozycji: 17.

Tytuł:: Could a Proto-Ribosome Emerge Spontaneously in the Prebiotic World?
Autorzy:: Agmon IC; Institute for Advanced Studies in Theoretical Chemistry, Schulich Faculty of Chemistry-Technion-Israel Institute of Technology, Haifa 32000, Israel. .; Fritz Haber Research Center for Molecular Dynamics, Hebrew University of Jerusalem, Jerusalem 91904, Israel. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2016 Dec 09; Vol. 21 (12). Date of Electronic Publication: 2016 Dec 09.
Typ publikacji:: Journal Article
MeSH Terms:: Evolution, Molecular*
Origin of Life*
Peptide Chain Elongation, Translational*
Ribosomes/*chemistry

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Skocz do pozycji: 18.

Tytuł:: The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones.
Autorzy:: Truttmann MC; Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America.
Cruz VE; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America.
Guo X; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America.
Engert C; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America.
Schwartz TU; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America.
Ploegh HL; Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America.; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America.; Pokaż więcej
Źródło:: PLoS genetics [PLoS Genet] 2016 May 03; Vol. 12 (5), pp. e1006023. Date of Electronic Publication: 2016 May 03 (Print Publication: 2016).
Typ publikacji:: Journal Article
MeSH Terms:: Peptide Chain Elongation, Translational*
Caenorhabditis elegans/*genetics
Caenorhabditis elegans Proteins/*genetics
DNA-Binding Proteins/*genetics
Nucleotidyltransferases/*genetics
Recombinant Proteins/*genetics
Animals ; Caenorhabditis elegans/chemistry ; Caenorhabditis elegans/microbiology ; Carrier Proteins/chemistry ; Carrier Proteins/genetics ; Crystallography, X-Ray ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; HSP70 Heat-Shock Proteins/chemistry ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Heat-Shock Response/genetics ; Histones/genetics ; Histones/metabolism ; Humans ; Immunity, Innate/genetics ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Protein Conformation ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/pathogenicity ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism

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Skocz do pozycji: 19.

Tytuł:: Full-length ribosome density prediction by a multi-input and multi-output model.
Autorzy:: Tian T; Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, China.
Li S; Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, China.
Lang P; Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, China.
Zhao D; Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, China.
Zeng J; Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, China.; MOE Key Laboratory of Bioinformatics, Tsinghua University, Beijing, China.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2021 Mar 26; Vol. 17 (3), pp. e1008842. Date of Electronic Publication: 2021 Mar 26 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Deep Learning*
Models, Genetic*
Ribosomes*/genetics
Ribosomes*/metabolism
Computational Biology/*methods
Peptide Chain Elongation, Translational/*genetics
Codon/genetics ; Codon/metabolism ; Escherichia coli/genetics ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Saccharomyces cerevisiae/genetics

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Skocz do pozycji: 20.

Tytuł:: Variability in mRNA translation: a random matrix theory approach.
Autorzy:: Margaliot M; Department of Electrical Engineering-Systems, Faculty of Engineering, Tel Aviv University, 69978, Tel Aviv, Israel.
Huleihel W; Department of Electrical Engineering-Systems, Faculty of Engineering, Tel Aviv University, 69978, Tel Aviv, Israel.
Tuller T; Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, 69978, Tel Aviv, Israel. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Mar 05; Vol. 11 (1), pp. 5300. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Models, Biological*
Protein Biosynthesis*
RNA, Messenger/*metabolism
Ribosomes/*metabolism
Humans ; Peptide Chain Elongation, Translational

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