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Tytuł :
Macromolecular assembly and membrane activity of antimicrobial D,L-α-Cyclic peptides.
Autorzy :
Claro B; CIQUP, Centro de Investigação em Química, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.
Peón A; CIQUP, Centro de Investigação em Química, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.
González-Freire E; Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Goormaghtigh E; Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, ULB, Brussels, Belgium.
Amorín M; Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Granja JR; Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Garcia-Fandiño R; CIQUP, Centro de Investigação em Química, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal; Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain. Electronic address: .
Bastos M; CIQUP, Centro de Investigação em Química, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal. Electronic address: .
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Źródło :
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2021 Dec; Vol. 208, pp. 112086. Date of Electronic Publication: 2021 Aug 31.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Infective Agents*/pharmacology
Peptides, Cyclic*
Anti-Bacterial Agents/pharmacology ; Lipid Bilayers ; Molecular Dynamics Simulation ; Peptides
Czasopismo naukowe
Tytuł :
Pegylated LyeTx I-b peptide is effective against carbapenem-resistant Acinetobacter baumannii in an in vivo model of pneumonia and shows reduced toxicity.
Autorzy :
César Moreira Brito J; Programa de Inovação Tecnológica e Biofarmacêutica, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil; Fundação Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil. Electronic address: .
Gustavo Lima W; Laboratório de Radioisótopos, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Campus Pampulha, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Magalhães Resende J; Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Cristina Sampaio de Assis D; Escola de Veterinária, Departamento de Inspeção Sanitária, Campus Pampulha, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil.
Boff D; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Nascimento Cardoso V; Laboratório de Radioisótopos, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Campus Pampulha, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Almeida Amaral F; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Maria Souza-Fagundes E; Programa de Inovação Tecnológica e Biofarmacêutica, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Odília Antunes Fernandes S; Laboratório de Radioisótopos, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Campus Pampulha, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Elena de Lima M; Programa de Inovação Tecnológica e Biofarmacêutica, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil; Faculdade Santa Casa de Belo Horizonte: Programa de Pós-Graduação em Medicina-Biomedicina, Belo Horizonte, Minas Gerais, Brazil. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 Nov 20; Vol. 609, pp. 121156. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Acinetobacter baumannii*
Antimicrobial Cationic Peptides*
Peptide Fragments*/pharmacology
Pneumonia*
Animals ; Carbapenems ; Drug Resistance, Bacterial ; Drug Synergism ; Gentamicins/pharmacology ; HEK293 Cells ; Humans ; Mice ; Microbial Sensitivity Tests ; Peptides ; Polyethylene Glycols ; Receptors for Activated C Kinase
Czasopismo naukowe
Tytuł :
Kinematic Reconstruction of Cyclic Peptides and Protein Backbones from Partial Data.
Autorzy :
Hassan M; Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York 11794, United States.
Coutsias EA; Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York 11794, United States.; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York 11794-5252, United States.
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Źródło :
Journal of chemical information and modeling [J Chem Inf Model] 2021 Oct 25; Vol. 61 (10), pp. 4975-5000. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptides, Cyclic*
Proteins*
Biomechanical Phenomena ; Peptides ; Protein Conformation
Czasopismo naukowe
Tytuł :
Insights on peptide topology in the computational design of protein ligands: the example of lysozyme binding peptides.
Autorzy :
Cantarutti C; Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 - Udine, Italy. .
Vargas MC; Departamento de Física Aplicada, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Unidad Mérida, Apartado Postal 73 'Cordemex', 97310, Mérida, Mexico.
Dongmo Foumthuim CJ; Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 - Udine, Italy. .; Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Campus Scientifico - Via Torino 155, 30172 Mestre, Italy.
Dumoulin M; Centre for Protein Engineering, InBios, Department of Life Sciences, University of Liege, Liege, Belgium.
La Manna S; Department of Pharmacy - University of Naples 'Federico II', 80134, Naples, Italy.
Marasco D; Department of Pharmacy - University of Naples 'Federico II', 80134, Naples, Italy.
Santambrogio C; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, Milan, Italy.
Grandori R; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, Milan, Italy.
Scoles G; Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 - Udine, Italy. .
Soler MA; Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 - Udine, Italy. .; Italian Institute of Technology (IIT), Via Melen - 83, B Block, 16152 - Genova, Italy.
Corazza A; Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 - Udine, Italy. .
Fortuna S; Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 - Udine, Italy. .; Italian Institute of Technology (IIT), Via Melen - 83, B Block, 16152 - Genova, Italy.; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy.
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Źródło :
Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2021 Oct 20; Vol. 23 (40), pp. 23158-23172. Date of Electronic Publication: 2021 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Ligands*
Molecular Dynamics Simulation*
Muramidase/*chemistry
Peptides/*chemistry
Algorithms ; Amino Acid Sequence ; Binding Sites ; Muramidase/metabolism ; Nuclear Magnetic Resonance, Biomolecular ; Peptides/metabolism ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/metabolism ; Protein Binding ; Spectrometry, Mass, Electrospray Ionization ; Surface Plasmon Resonance
Czasopismo naukowe
Tytuł :
Polyalanine peptide variations may have different mechanisms of action against multidrug-resistant bacterial pathogens.
Autorzy :
Felício MR; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal.
Silveira GGOS; S-Inova Biotech, Pós-graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil.
Oshiro KGN; S-Inova Biotech, Pós-graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil.; Programa de Pós-Graduação em Patologia Molecular, Universidade de Brasília, Brasília, DF, Brazil.
Meneguetti BT; S-Inova Biotech, Pós-graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil.
Franco OL; S-Inova Biotech, Pós-graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil.; Programa de Pós-Graduação em Patologia Molecular, Universidade de Brasília, Brasília, DF, Brazil.; Centro de Análises Proteômicas e Bioquímicas, Pós-graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, DF, Brazil.
Santos NC; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal.
Gonçalves S; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal.
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Źródło :
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2021 Apr 13; Vol. 76 (5), pp. 1174-1186.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antimicrobial Cationic Peptides*/pharmacology
Escherichia coli*
Anti-Bacterial Agents/pharmacology ; Drug Resistance, Multiple, Bacterial ; Microbial Sensitivity Tests ; Peptides
Czasopismo naukowe
Tytuł :
Nanoscale Visualization of Morphological Alteration of Live-Cell Membranes by the Interaction with Oligoarginine Cell-Penetrating Peptides.
Autorzy :
Ida H; The Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan.; Precursory Research for Embryonic Science and Technology, Science and Technology Agency (JST), Saitama 332-0012, Japan.; Advanced Institute for Materials Research, Tohoku University, Sendai, Miyagi 980-8577, Japan.; Graduate School of Environmental Studies, Tohoku University, Sendai, Miyagi 980-8579, Japan.
Takahashi Y; Precursory Research for Embryonic Science and Technology, Science and Technology Agency (JST), Saitama 332-0012, Japan.; WPI Nano Life Science Institute (WPI NanoLSI), Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan.
Kumatani A; Advanced Institute for Materials Research, Tohoku University, Sendai, Miyagi 980-8577, Japan.; Graduate School of Environmental Studies, Tohoku University, Sendai, Miyagi 980-8579, Japan.; International Center for Materials Nanoarchitectonics, National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044, Japan.; Center for Science and Innovation in Spintronics (CSIS), Tohoku University, Sendai, Miyagi 980-8577 Japan.
Shiku H; Graduate School of Environmental Studies, Tohoku University, Sendai, Miyagi 980-8579, Japan.
Murayama T; Institute for Chemical Research, Kyoto University, Kyoto 611-0011, Japan.
Hirose H; Institute for Chemical Research, Kyoto University, Kyoto 611-0011, Japan.
Futaki S; Institute for Chemical Research, Kyoto University, Kyoto 611-0011, Japan.
Matsue T; Graduate School of Environmental Studies, Tohoku University, Sendai, Miyagi 980-8579, Japan.
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Źródło :
Analytical chemistry [Anal Chem] 2021 Apr 06; Vol. 93 (13), pp. 5383-5393. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell-Penetrating Peptides*
Arginine ; Cell Membrane ; Microscopy, Confocal ; Peptides
Czasopismo naukowe
Tytuł :
Antimicrobial Peptides and Cell-Penetrating Peptides for Treating Intracellular Bacterial Infections.
Autorzy :
Buccini DF; S-inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, Brazil.
Cardoso MH; S-inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, Brazil.; Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, Brazil.
Franco OL; S-inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, Brazil.; Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, Brazil.
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Źródło :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2021 Feb 05; Vol. 10, pp. 612931. Date of Electronic Publication: 2021 Feb 05 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Bacterial Infections*/drug therapy
Cell-Penetrating Peptides*
Anti-Bacterial Agents/pharmacology ; Antimicrobial Cationic Peptides/pharmacology ; Humans ; Pore Forming Cytotoxic Proteins
Czasopismo naukowe
Tytuł :
The Central PXXP Motif Is Crucial for PMAP-23 Translocation across the Lipid Bilayer.
Autorzy :
Yang ST; Department of Microbiology, School of Medicine, Chosun University, Gwangju 61452, Korea.
Shin SY; Department of Cellular and Molecular Medicine, School of Medicine, Chosun University, Gwangju 61452, Korea.
Shin SH; Department of Microbiology, School of Medicine, Chosun University, Gwangju 61452, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 09; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Motifs*
Lipid Bilayers*
Protein Interaction Domains and Motifs*
Antimicrobial Cationic Peptides/*chemistry
Antimicrobial Cationic Peptides/*metabolism
Cell Membrane/*metabolism
Amino Acid Sequence ; Animals ; Bacteria ; Mice ; Models, Biological ; Peptides/chemistry ; Peptides/metabolism ; Protein Structure, Secondary ; Protein Transport ; Surface Plasmon Resonance ; Swine
Czasopismo naukowe
Tytuł :
Secreted Frizzled-Related Protein 1 Promotes Odontoblastic Differentiation and Reparative Dentin Formation in Dental Pulp Cells.
Autorzy :
Ipposhi K; Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Tomokiyo A; Department of Endodontology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
Ono T; Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Yamashita K; Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Alhasan MA; Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Hasegawa D; Department of Endodontology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
Hamano S; Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.; OBT Center, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Yoshida S; Department of Endodontology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
Sugii H; Department of Endodontology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
Itoyama T; Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Ogawa M; Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Maeda H; Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.; Department of Endodontology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
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Źródło :
Cells [Cells] 2021 Sep 21; Vol. 10 (9). Date of Electronic Publication: 2021 Sep 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dental Pulp/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Odontoblasts/*metabolism
Adolescent ; Animals ; Cell Differentiation/genetics ; Dental Pulp/physiology ; Dentin/metabolism ; Dentin/physiology ; Dentin, Secondary/physiology ; Dentinogenesis/genetics ; Dentinogenesis/physiology ; Female ; Gene Expression/genetics ; Humans ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/physiology ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Odontoblasts/physiology ; Rats ; Rats, Wistar ; Signal Transduction/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo.
Autorzy :
Yu S; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Yang H; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Li T; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Pan H; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Ren S; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Luo G; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Jiang J; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Yu L; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Chen B; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Zhang Y; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Wang S; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Tian R; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Zhang T; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Zhang S; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Chen Y; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Yuan Q; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China. .
Ge S; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China. .
Zhang J; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China.
Xia N; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Centers of Biological Products, School of Public Health, Xiamen University, Xiamen, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 26; Vol. 12 (1), pp. 5131. Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Delivery Systems/*methods
Liver Failure, Acute/*drug therapy
Peptides/*chemistry
Protein Phosphatase 1/*administration & dosage
Animals ; Cell-Penetrating Peptides/chemistry ; Cell-Penetrating Peptides/genetics ; Cell-Penetrating Peptides/metabolism ; Endosomes/genetics ; Endosomes/metabolism ; Humans ; Hydrogen-Ion Concentration ; Liver Failure, Acute/genetics ; Liver Failure, Acute/metabolism ; Mice, Inbred BALB C ; Peptides/genetics ; Peptides/metabolism ; Protein Phosphatase 1/chemistry ; Protein Phosphatase 1/genetics ; Protein Phosphatase 1/metabolism ; Protein Transport
Czasopismo naukowe
Tytuł :
Endosome-escaping micelle complexes dually equipped with cell-penetrating and endosome-disrupting peptides for efficient DNA delivery into intact plants.
Autorzy :
Miyamoto T; Biomacromolecules Research Team, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan. .
Tsuchiya K
Numata K
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Źródło :
Nanoscale [Nanoscale] 2021 Mar 21; Vol. 13 (11), pp. 5679-5692. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article
MeSH Terms :
Cell-Penetrating Peptides*
Micelles*
DNA ; Endosomes ; Peptides ; Transfection
Czasopismo naukowe
Tytuł :
Generation of a 100-billion cyclic peptide phage display library having a high skeletal diversity.
Autorzy :
Carle V; Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.
Kong XD; Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.
Comberlato A; Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.
Edwards C; Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.
Díaz-Perlas C; Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.
Heinis C; Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.
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Źródło :
Protein engineering, design & selection : PEDS [Protein Eng Des Sel] 2021 Feb 15; Vol. 34.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Library*
Peptides*/genetics
Ligands ; Peptides, Cyclic ; Plasmids
Czasopismo naukowe
Tytuł :
Transcription factor FOXC1 positively regulates SFRP1 expression in androgenetic alopecia.
Autorzy :
Zhou LB; Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Cao Q; Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Ding Q; Department of Dermatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Sun WL; Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Li ZY; Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Zhao M; Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Lin XW; Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Zhou GP; Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Fan WX; Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Jul 01; Vol. 404 (1), pp. 112618. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alopecia/*metabolism
Forkhead Transcription Factors/*metabolism
Hair Follicle/*metabolism
Intercellular Signaling Peptides and Proteins/*metabolism
Membrane Proteins/*metabolism
Alopecia/drug therapy ; Alopecia/genetics ; Dermis/metabolism ; Gene Expression Regulation/genetics ; Humans ; Intracellular Signaling Peptides and Proteins ; Male ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Penaeidins restrict white spot syndrome virus infection by antagonizing the envelope proteins to block viral entry.
Autorzy :
Xiao B; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)/ School of Marine Sciences, Sun Yat-sen University, Guangzhou, P. R. People's Republic of China.; State Key Laboratory of Biocontrol/ School of Life Sciences, Sun Yat-sen University, Guangzhou, P. R. People's Republic of China.
Fu Q; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)/ School of Marine Sciences, Sun Yat-sen University, Guangzhou, P. R. People's Republic of China.; State Key Laboratory of Biocontrol/ School of Life Sciences, Sun Yat-sen University, Guangzhou, P. R. People's Republic of China.
Niu S; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)/ School of Marine Sciences, Sun Yat-sen University, Guangzhou, P. R. People's Republic of China.; State Key Laboratory of Biocontrol/ School of Life Sciences, Sun Yat-sen University, Guangzhou, P. R. People's Republic of China.
Zhu P; Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation, Beibu Gluf University, Qinzhou, P. R. People's Republic of China.
He J; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)/ School of Marine Sciences, Sun Yat-sen University, Guangzhou, P. R. People's Republic of China.; State Key Laboratory of Biocontrol/ School of Life Sciences, Sun Yat-sen University, Guangzhou, P. R. People's Republic of China.
Li C; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)/ School of Marine Sciences, Sun Yat-sen University, Guangzhou, P. R. People's Republic of China.; State Key Laboratory of Biocontrol/ School of Life Sciences, Sun Yat-sen University, Guangzhou, P. R. People's Republic of China.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2020 Dec; Vol. 9 (1), pp. 390-412.
Typ publikacji :
Journal Article
MeSH Terms :
Peptides*/genetics
Peptides*/pharmacology
Antiviral Agents/*pharmacology
Penaeidae/*virology
White spot syndrome virus 1/*drug effects
Animals ; Antimicrobial Cationic Peptides/genetics ; Antimicrobial Cationic Peptides/pharmacology ; Gene Expression ; Hemocytes/virology ; Viral Envelope Proteins/drug effects ; Virus Internalization/drug effects ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration.
Autorzy :
Sreekumar PG; The Stephen J. Ryan Initiative for Macular Research (RIMR), Doheny Eye Institute, Los Angeles, CA, 90033, USA.
Kannan R; The Stephen J. Ryan Initiative for Macular Research (RIMR), Doheny Eye Institute, Los Angeles, CA, 90033, USA; Stein Eye Institute, Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. Electronic address: .
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Źródło :
Redox biology [Redox Biol] 2020 Oct; Vol. 37, pp. 101663. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Intracellular Signaling Peptides and Proteins*/pharmacology
Macular Degeneration*/drug therapy
Macular Degeneration*/genetics
Metal Nanoparticles*
Retinal Pigments*/pharmacology
Animals ; Caenorhabditis elegans ; Endothelial Cells ; HEK293 Cells ; HeLa Cells ; Humans ; Mice ; Mice, Inbred NOD ; Mitochondria/drug effects ; Neurons ; Oxidants/pharmacology ; Peptides ; RNA, Ribosomal, 16S ; Silver
Czasopismo naukowe
Tytuł :
Pharmacokinetics and Molecular Modeling Indicate nAChRα4-Derived Peptide HAEE Goes through the Blood-Brain Barrier.
Autorzy :
Zolotarev YA; Laboratory of Protein Conformational Polymorphism in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.; Department of Physiologically Active Substances Chemistry, Institute of Molecular Genetics of National Research Center «Kurchatov Institute», 123182 Moscow, Russia.
Mitkevich VA; Laboratory of Protein Conformational Polymorphism in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Shram SI; Department of Physiologically Active Substances Chemistry, Institute of Molecular Genetics of National Research Center «Kurchatov Institute», 123182 Moscow, Russia.
Adzhubei AA; Laboratory of Protein Conformational Polymorphism in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Tolstova AP; Laboratory of Protein Conformational Polymorphism in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Talibov OB; Department of Clinical Pharmacology, Faculty of Common Medicine, Evdokimov Moscow State University of Medicine and Dentistry, 127473 Moscow, Russia.
Dadayan AK; Department of Physiologically Active Substances Chemistry, Institute of Molecular Genetics of National Research Center «Kurchatov Institute», 123182 Moscow, Russia.
Myasoyedov NF; Department of Physiologically Active Substances Chemistry, Institute of Molecular Genetics of National Research Center «Kurchatov Institute», 123182 Moscow, Russia.
Makarov AA; Laboratory of Protein Conformational Polymorphism in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Kozin SA; Laboratory of Protein Conformational Polymorphism in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
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Źródło :
Biomolecules [Biomolecules] 2021 Jun 18; Vol. 11 (6). Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptides/*pharmacokinetics
Peptides/*pharmacology
Receptors, Nicotinic/*genetics
Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/drug effects ; Amyloid beta-Peptides/metabolism ; Animals ; Biological Transport ; Blood-Brain Barrier/drug effects ; Brain/metabolism ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL ; Models, Molecular ; Peptide Fragments/metabolism ; Peptide Fragments/pharmacology ; Peptides/genetics ; Rabbits ; Rats ; Rats, Wistar ; Receptors, Nicotinic/physiology
Czasopismo naukowe
Tytuł :
Therapeutic Potential of Novel Mastoparan-Chitosan Nanoconstructs Against Clinical MDR Acinetobacter baumannii : In silico, in vitro and in vivo Studies.
Autorzy :
Hassan A; Department of Microbiology, Armed Forces Institute of Pathology, National University of Medical Sciences, Rawalpindi, Pakistan.
Ikram A; Department of Microbiology, Armed Forces Institute of Pathology, National University of Medical Sciences, Rawalpindi, Pakistan.
Raza A; NILOP Nanomedicine Research Laboratories, National Institute of Lasers and Optronics College, Pakistan Institute of Engineering and Applied Sciences, Islamabad, Pakistan.
Saeed S; NILOP Nanomedicine Research Laboratories, National Institute of Lasers and Optronics College, Pakistan Institute of Engineering and Applied Sciences, Islamabad, Pakistan.
Zafar Paracha R; National University of Sciences and Technology, Islamabad, Pakistan.
Younas Z; Department of Microbiology, Armed Forces Institute of Pathology, National University of Medical Sciences, Rawalpindi, Pakistan.
Khadim MT; Department of Microbiology, Armed Forces Institute of Pathology, National University of Medical Sciences, Rawalpindi, Pakistan.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 Jun 01; Vol. 16, pp. 3755-3773. Date of Electronic Publication: 2021 Jun 01 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Acinetobacter baumannii/*drug effects
Chitosan/*chemistry
Intercellular Signaling Peptides and Proteins/*pharmacology
Nanoparticles/*chemistry
Wasp Venoms/*pharmacology
Acinetobacter baumannii/growth & development ; Acinetobacter baumannii/isolation & purification ; Adolescent ; Adult ; Animals ; Anti-Bacterial Agents/pharmacology ; Child ; Child, Preschool ; Disease Models, Animal ; Drug Resistance, Multiple, Bacterial/drug effects ; Female ; Humans ; Male ; Mice, Inbred BALB C ; Microbial Sensitivity Tests ; Middle Aged ; Molecular Dynamics Simulation ; Nanoparticles/ultrastructure ; Peptide Hydrolases/metabolism ; Peptides/chemistry ; Peptides/pharmacology ; Young Adult
Czasopismo naukowe
Tytuł :
Expanding the range of sub/supercritical fluid chromatography: Advantageous use of methanesulfonic acid in water-rich modifiers for peptide analysis.
Autorzy :
Losacco GL; School of Pharmaceutical Sciences, University of Geneva, CMU - Rue Michel-Servet 1, 1211 Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU - Rue Michel-Servet 1, 1211 Geneva 4, Switzerland.
DaSilva JO; Analytical Research and Development, MRL, Merck & Co, Inc., 126 E. Lincoln Ave, Rahway, NJ 07065, United States.
Liu J; Analytical Research and Development, MRL, Merck & Co, Inc., 126 E. Lincoln Ave, Rahway, NJ 07065, United States.
Regalado EL; Analytical Research and Development, MRL, Merck & Co, Inc., 126 E. Lincoln Ave, Rahway, NJ 07065, United States.
Veuthey JL; School of Pharmaceutical Sciences, University of Geneva, CMU - Rue Michel-Servet 1, 1211 Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU - Rue Michel-Servet 1, 1211 Geneva 4, Switzerland.
Guillarme D; School of Pharmaceutical Sciences, University of Geneva, CMU - Rue Michel-Servet 1, 1211 Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU - Rue Michel-Servet 1, 1211 Geneva 4, Switzerland. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Apr 12; Vol. 1642, pp. 462048. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, Supercritical Fluid/*methods
Mesylates/*analysis
Peptides/*analysis
Water/*chemistry
Amino Acid Sequence ; Chromatography, High Pressure Liquid/methods ; Peptides/chemistry ; Peptides, Cyclic/analysis ; Spectrophotometry, Ultraviolet ; Trifluoroacetic Acid/chemistry
Czasopismo naukowe
Tytuł :
Inhibition of Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 (MK2) is Protective in Pulmonary Hypertension.
Autorzy :
Shafiq M; From the Division of Pharmacology (M.S., K.J., K.H.), CSIR-Central Drug Research Institute, Lucknow, India.; Academy of Scientific and Innovative Research, Ghaziabad, India (M.S., K.J., K.H.).
Jagavelu K; From the Division of Pharmacology (M.S., K.J., K.H.), CSIR-Central Drug Research Institute, Lucknow, India.; Academy of Scientific and Innovative Research, Ghaziabad, India (M.S., K.J., K.H.).
Iqbal H; Department of Molecular Bio-Prospection, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India (H.I., P.Y., D.C.).
Yadav P; Department of Molecular Bio-Prospection, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India (H.I., P.Y., D.C.).
Chanda D; Department of Molecular Bio-Prospection, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India (H.I., P.Y., D.C.).
Verma NK; Division of Molecular and Structural Biology (N.K.V., J.K.G.), CSIR-Central Drug Research Institute, Lucknow, India.
Ghosh JK; Division of Molecular and Structural Biology (N.K.V., J.K.G.), CSIR-Central Drug Research Institute, Lucknow, India.
Gaestel M; Institute for Zellbiochemie, Medizinische Hochschule Hannover (MHH), Hanover, Germany (M.G.).
Hanif K; From the Division of Pharmacology (M.S., K.J., K.H.), CSIR-Central Drug Research Institute, Lucknow, India.; Academy of Scientific and Innovative Research, Ghaziabad, India (M.S., K.J., K.H.).
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Źródło :
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2021 Apr; Vol. 77 (4), pp. 1248-1259. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypertension, Pulmonary*/metabolism
Hypertension, Pulmonary*/physiopathology
Hypertension, Pulmonary*/therapy
Intracellular Signaling Peptides and Proteins*/antagonists & inhibitors
Intracellular Signaling Peptides and Proteins*/metabolism
Protein-Serine-Threonine Kinases*/antagonists & inhibitors
Protein-Serine-Threonine Kinases*/metabolism
Pulmonary Artery*/metabolism
Pulmonary Artery*/physiopathology
Muscle, Smooth, Vascular/*metabolism
Peptides/*pharmacology
Animals ; Apoptosis/drug effects ; Cell Proliferation ; Cells, Cultured ; Enzyme Inhibitors/pharmacology ; Humans ; Hypoxia/metabolism ; Inflammation/metabolism ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley ; Vascular Remodeling/drug effects
Czasopismo naukowe
Tytuł :
A two-pronged attack.
Autorzy :
Feng JJ; Department of Chemistry & Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, CA, USA.
Zhang C; Department of Chemistry & Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, CA, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2020 Nov; Vol. 16 (11), pp. 1154-1155.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Peptides*
Proto-Oncogene Proteins B-raf*
Intercellular Signaling Peptides and Proteins
Czasopismo naukowe

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