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Tytuł :
Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry.
Autorzy :
Ren W; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China.
Zhu Y; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China.
Wang Y; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China.
Shi H; CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Yu Y; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China.
Hu G; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China.
Feng F; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China.
Zhao X; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China.
Lan J; School of Life Sciences, Tsinghua University, Beijing, China.
Wu J; Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
Kenney DJ; Department of Microbiology, National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Douam F; Department of Microbiology, National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Tong Y; CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Zhong J; CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Xie Y; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China.
Wang X; School of Life Sciences, Tsinghua University, Beijing, China.; Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing China.
Yuan Z; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China.
Zhou D; Department of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Zhang R; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China.
Ding Q; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China.; Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing China.
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Źródło :
PLoS pathogens [PLoS Pathog] 2021 Mar 24; Vol. 17 (3), pp. e1009392. Date of Electronic Publication: 2021 Mar 24 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*enzymology
COVID-19/*genetics
Peptidyl-Dipeptidase A/*genetics
Receptors, Virus/*genetics
SARS-CoV-2/*physiology
Animals ; Base Sequence ; COVID-19/virology ; Host Specificity ; Humans ; Mice/genetics ; Mice/virology ; Peptidyl-Dipeptidase A/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Phascolarctidae/genetics ; Phascolarctidae/virology ; Receptors, Virus/metabolism ; SARS-CoV-2/genetics ; Sequence Alignment ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
Czasopismo naukowe
Tytuł :
How Important Is the Assessment of Soluble ACE-2 in COVID-19?
Autorzy :
Rojas M; Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.
Acosta-Ampudia Y; Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.
Monsalve DM; Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.
Ramírez-Santana C; Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.
Anaya JM; Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.; Rheumatology unit, Clínica de Occidente, Bogota, Colombia.
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Źródło :
American journal of hypertension [Am J Hypertens] 2021 Apr 02; Vol. 34 (3), pp. 296-297.
Typ publikacji :
Letter; Comment
MeSH Terms :
COVID-19*
Peptidyl-Dipeptidase A*
Aldosterone ; Angiotensin II ; Humans ; SARS-CoV-2
Opinia redakcyjna
Tytuł :
Commentary for "Endocrine significance of SARS-CoV-2's Reliance on ACE2".
Autorzy :
Chappell MC; Cardiovascular Sciences Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
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Źródło :
Endocrinology [Endocrinology] 2021 Apr 01; Vol. 162 (4).
Typ publikacji :
Journal Article; Comment
MeSH Terms :
COVID-19*
Peptidyl-Dipeptidase A*/metabolism
Humans ; Renin-Angiotensin System ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Exposure to particulate matter upregulates ACE2 and TMPRSS2 expression in the murine lung.
Autorzy :
Sagawa T; Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan; Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Tsujikawa T; Department of Otolaryngology - Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Honda A; Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan; Graduate School of Global Environmental Studies, Kyoto University, Kyoto, Japan.
Miyasaka N; Graduate School of Global Environmental Studies, Kyoto University, Kyoto, Japan.
Tanaka M; Graduate School of Global Environmental Studies, Kyoto University, Kyoto, Japan.
Kida T; Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hasegawa K; Department of Respiratory Medicine, Takatsuki Red Cross Hospital, Takatsuki, Japan.
Okuda T; Faculty of Science and Technology, Keio University, Kanagawa, Japan.
Kawahito Y; Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Takano H; Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan; Graduate School of Global Environmental Studies, Kyoto University, Kyoto, Japan.
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Źródło :
Environmental research [Environ Res] 2021 Apr; Vol. 195, pp. 110722. Date of Electronic Publication: 2021 Jan 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*
Peptidyl-Dipeptidase A*/genetics
Angiotensin-Converting Enzyme 2 ; Animals ; Humans ; Lung ; Mice ; Particulate Matter/toxicity ; SARS-CoV-2 ; Serine Endopeptidases/genetics
Czasopismo naukowe
Tytuł :
Identification of post-digestion angiotensin-I converting enzyme (ACE) inhibitory peptides from soybean protein Isolate: Their production conditions and in silico molecular docking with ACE.
Autorzy :
Xu Z; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Guangdong Huapeptide Biotechnology Co., Ltd., Zhaoqing 526238, China.
Wu C; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China.
Sun-Waterhouse D; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Zhao T; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Waterhouse GIN; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Zhao M; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China; Guangdong Huapeptide Biotechnology Co., Ltd., Zhaoqing 526238, China.
Su G; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 May 30; Vol. 345, pp. 128855. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Digestion*
Molecular Docking Simulation*
Angiotensin-Converting Enzyme Inhibitors/*analysis
Peptides/*analysis
Peptidyl-Dipeptidase A/*metabolism
Soybean Proteins/*chemistry
Angiotensin-Converting Enzyme Inhibitors/metabolism ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Hydrophobic and Hydrophilic Interactions ; Peptides/metabolism ; Peptides/pharmacology ; Peptidyl-Dipeptidase A/chemistry ; Protein Conformation
Czasopismo naukowe
Tytuł :
Design of an engineered ACE2 as a novel therapeutics against COVID-19.
Autorzy :
Payandeh Z; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Rahbar MR; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Jahangiri A; Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Hashemi ZS; ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Zakeri A; Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran.
Jafarisani M; Clinical Biochemistry, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Rasaee MJ; Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Khalili S; Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran. Electronic address: .
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Źródło :
Journal of theoretical biology [J Theor Biol] 2020 Nov 21; Vol. 505, pp. 110425. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Betacoronavirus/*metabolism
Coronavirus Infections/*drug therapy
Peptidyl-Dipeptidase A/*genetics
Peptidyl-Dipeptidase A/*metabolism
Pneumonia, Viral/*drug therapy
Protein Engineering/*methods
Amino Acid Substitution ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus/genetics ; Binding Sites ; COVID-19 ; Directed Molecular Evolution ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/therapeutic use ; Protein Binding ; Protein Interaction Domains and Motifs/genetics ; Protein Stability ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł :
Role of neutrophil chemoattractant CXCL5 in SARS-CoV-2 infection-induced lung inflammatory innate immune response in an in vivo hACE2 transfection mouse model.
Autorzy :
Liang Y; Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan 650118, China.
Li H; Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan 650118, China.
Li J; Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan 650118, China.
Yang ZN; Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan 650118, China.
Li JL; Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan 650118, China.
Zheng HW; Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan 650118, China.
Chen YL; Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan 650118, China.
Shi HJ; Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan 650118, China.
Guo L; Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan 650118, China. E-mail: .
Liu LD; Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan 650118, China. E-mail: .
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Źródło :
Zoological research [Zool Res] 2020 Nov 18; Vol. 41 (6), pp. 621-631.
Typ publikacji :
Journal Article
MeSH Terms :
Betacoronavirus/*immunology
Chemokine CXCL5/*immunology
Coronavirus Infections/*immunology
Immunity, Innate/*immunology
Neutrophils/*immunology
Peptidyl-Dipeptidase A/*immunology
Pneumonia, Viral/*immunology
Angiotensin-Converting Enzyme 2 ; Animals ; Betacoronavirus/genetics ; Betacoronavirus/physiology ; COVID-19 ; Cell Line ; Chemokine CXCL5/genetics ; Chemokine CXCL5/metabolism ; Coronavirus Infections/genetics ; Coronavirus Infections/virology ; Cytokines/immunology ; Cytokines/metabolism ; Disease Models, Animal ; Humans ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Neutrophils/metabolism ; Neutrophils/virology ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/genetics ; Pneumonia, Viral/virology ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery.
Autorzy :
Lores E; Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, U.S.A.
Wysocki J; Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, U.S.A.
Batlle D; Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, U.S.A.
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Źródło :
Clinical science (London, England : 1979) [Clin Sci (Lond)] 2020 Nov 13; Vol. 134 (21), pp. 2791-2805.
Typ publikacji :
Historical Article; Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Betacoronavirus/*pathogenicity
Coronavirus Infections/*enzymology
Kidney/*enzymology
Kidney Diseases/*enzymology
Peptidyl-Dipeptidase A/*metabolism
Pneumonia, Viral/*enzymology
Receptors, Virus/*metabolism
Acute Kidney Injury/enzymology ; Acute Kidney Injury/virology ; Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Diabetes Mellitus/enzymology ; Diabetes Mellitus/physiopathology ; History, 21st Century ; Host-Pathogen Interactions ; Humans ; Hypertension/enzymology ; Hypertension/physiopathology ; Kidney/physiopathology ; Kidney Diseases/drug therapy ; Kidney Diseases/physiopathology ; Pandemics ; Peptidyl-Dipeptidase A/history ; Peptidyl-Dipeptidase A/therapeutic use ; Pneumonia, Viral/virology ; Receptors, Virus/history ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Studying the Effects of ACE2 Mutations on the Stability, Dynamics, and Dissociation Process of SARS-CoV-2 S1/hACE2 Complexes.
Autorzy :
Hadi-Alijanvand H; Department of Biological Sciences, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran.
Rouhani M; Department of Biological Sciences, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran.
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Źródło :
Journal of proteome research [J Proteome Res] 2020 Nov 06; Vol. 19 (11), pp. 4609-4623. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation, Missense*/genetics
Mutation, Missense*/physiology
Peptidyl-Dipeptidase A*/chemistry
Peptidyl-Dipeptidase A*/genetics
Peptidyl-Dipeptidase A*/metabolism
Spike Glycoprotein, Coronavirus*/chemistry
Spike Glycoprotein, Coronavirus*/metabolism
Angiotensin-Converting Enzyme 2 ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Iran ; Molecular Dynamics Simulation ; Pandemics ; Pneumonia, Viral ; Protein Binding ; SARS-CoV-2 ; Thermodynamics
Czasopismo naukowe
Tytuł :
ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population.
Autorzy :
Benetti E; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Tita R; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Spiga O; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Ciolfi A; Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.
Birolo G; Department of Medical Sciences, University of Turin, Turin, Italy.
Bruselles A; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Doddato G; Medical Genetics, University of Siena, Siena, Italy.
Giliberti A; Medical Genetics, University of Siena, Siena, Italy.
Marconi C; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Musacchia F; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.
Pippucci T; Sant'Orsola-Malpighi University Hospital, Bologna, Italy.
Torella A; Dipartimento di Medicina di Precisione, Università della Campania 'Luigi Vanvitelli', Napoli, Italy.
Trezza A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Valentino F; Medical Genetics, University of Siena, Siena, Italy.
Baldassarri M; Medical Genetics, University of Siena, Siena, Italy.
Brusco A; Department of Medical Sciences, University of Turin, Turin, Italy.; Genetica Medica, Città della Salute e della Scienza, Torino, Italy.
Asselta R; Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy.; Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy.
Bruttini M; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.; Medical Genetics, University of Siena, Siena, Italy.
Furini S; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Seri M; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.; Sant'Orsola-Malpighi University Hospital, Bologna, Italy.
Nigro V; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.; Dipartimento di Medicina di Precisione, Università della Campania 'Luigi Vanvitelli', Napoli, Italy.
Matullo G; Department of Medical Sciences, University of Turin, Turin, Italy.; Genetica Medica, Città della Salute e della Scienza, Torino, Italy.
Tartaglia M; Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.
Mari F; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.; Medical Genetics, University of Siena, Siena, Italy.
Renieri A; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy. .; Medical Genetics, University of Siena, Siena, Italy. .
Pinto AM; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
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Corporate Authors :
GEN-COVID Multicenter Study
Źródło :
European journal of human genetics : EJHG [Eur J Hum Genet] 2020 Nov; Vol. 28 (11), pp. 1602-1614. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus Infections/*genetics
Peptidyl-Dipeptidase A/*genetics
Pneumonia, Viral/*genetics
Aged ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus/chemistry ; COVID-19 ; Cohort Studies ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Databases, Genetic ; Female ; Frameshift Mutation ; Genetic Predisposition to Disease ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Molecular Dynamics Simulation ; Mutation, Missense ; Pandemics ; Peptidyl-Dipeptidase A/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Protein Stability ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Engaging the spikes: heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection.
Autorzy :
Kalra RS; AIST-INDIA DAILAB, National Institute of Advanced Industrial Science & Technology (AIST), Higashi 1-1-1, Tsukuba, Japan. .; Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa, 904-0495, Japan. .
Kandimalla R; Applied Biology, CSIR-Indian Institute of Chemical Technology (IICT), Uppal Road, Tarnaka, Hyderabad, Telangana State, India. .; Department of Biochemistry, Kakatiya Medical College, Warangal, Telangana, 506004, India. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Jan 29; Vol. 6 (1), pp. 39. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
COVID-19*
Peptidyl-Dipeptidase A*/metabolism
Heparitin Sulfate ; Humans ; Protein Binding ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
Czasopismo naukowe
Tytuł :
Not only ACE2-the quest for additional host cell mediators of SARS-CoV-2 infection: Neuropilin-1 (NRP1) as a novel SARS-CoV-2 host cell entry mediator implicated in COVID-19.
Autorzy :
Kyrou I; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, CV2 2DX, UK. .; Aston Medical Research Institute, Aston Medical School, College of Health and Life Sciences, Aston University, Birmingham, B4 7ET, UK. .; Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK. .
Randeva HS; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, CV2 2DX, UK.; Aston Medical Research Institute, Aston Medical School, College of Health and Life Sciences, Aston University, Birmingham, B4 7ET, UK.; Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.
Spandidos DA; Laboratory of Clinical Virology, Medical School, University of Crete, 71409, Heraklion, Greece.
Karteris E; Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, UK.
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Jan 18; Vol. 6 (1), pp. 21. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
COVID-19*
Peptidyl-Dipeptidase A*/genetics
Humans ; Neuropilin-1/genetics ; SARS-CoV-2 ; Virus Internalization
Czasopismo naukowe
Tytuł :
Lessons From COVID-19, ACE2, and Intestinal Inflammation: Could a Virus Trigger Chronic Intestinal Inflammation?
Autorzy :
Hanrahan TP; Department of Gastroenterology, Northern Hospital, Melbourne, Victoria, Australia.
Lubel JS; Department of Gastroenterology, Alfred Hospital and Monash University, Melbourne, Victoria, Australia.
Garg M; Department of Gastroenterology, Northern Hospital, Department of Gastroenterology, Royal Melbourne Hospital, Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
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Źródło :
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2021 Jan; Vol. 19 (1), pp. 206. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Letter; Comment
MeSH Terms :
COVID-19*
Peptidyl-Dipeptidase A*
Diarrhea ; Humans ; Inflammation ; SARS-CoV-2
Opinia redakcyjna
Tytuł :
Is there an underlying link between COVID-19, ACE2, oxytocin and vitamin D?
Autorzy :
Diep PT; Department of Histopathology, Royal Lancaster Infirmary, University Hospitals of Morecambe Bay NHS Foundation Trust, Lancaster, United Kingdom. Electronic address: .
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Źródło :
Medical hypotheses [Med Hypotheses] 2021 Jan; Vol. 146, pp. 110360. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Letter; Comment
MeSH Terms :
COVID-19*
Peptidyl-Dipeptidase A*
Humans ; Oxytocin ; SARS-CoV-2 ; Vitamin D
Opinia redakcyjna
Tytuł :
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling.
Autorzy :
Israelow B; Department of Immunobiology, Yale University School of Medicine, New Haven, CT.; Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT.
Song E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT.
Mao T; Department of Immunobiology, Yale University School of Medicine, New Haven, CT.
Lu P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT.
Meir A; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT.
Liu F; Department of Immunobiology, Yale University School of Medicine, New Haven, CT.
Alfajaro MM; Department of Immunobiology, Yale University School of Medicine, New Haven, CT.; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT.
Wei J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT.; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT.
Dong H; Department of Immunobiology, Yale University School of Medicine, New Haven, CT.
Homer RJ; Department of Pathology, Yale University School of Medicine, New Haven, CT.
Ring A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT.
Wilen CB; Department of Immunobiology, Yale University School of Medicine, New Haven, CT.; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT.
Iwasaki A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT.; Howard Hughes Medical Institute, Chevy Chase, MD.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2020 Dec 07; Vol. 217 (12).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Disease Models, Animal*
Betacoronavirus/*metabolism
Coronavirus Infections/*metabolism
Interferon Type I/*metabolism
Mice/*genetics
Peptidyl-Dipeptidase A/*metabolism
Pneumonia, Viral/*metabolism
Angiotensin-Converting Enzyme 2 ; Animals ; COVID-19 ; Cell Line, Tumor ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Dependovirus/genetics ; Female ; Humans ; Inflammation/metabolism ; Lung/pathology ; Lung/virology ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Pandemics ; Parvoviridae Infections/metabolism ; Parvoviridae Infections/virology ; Peptidyl-Dipeptidase A/genetics ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Signal Transduction/genetics ; Virus Replication/genetics
Czasopismo naukowe
Tytuł :
Development of multi-specific humanized llama antibodies blocking SARS-CoV-2/ACE2 interaction with high affinity and avidity.
Autorzy :
Dong J; Ab Studio Inc., Hayward, CA, USA.
Huang B; Ab Studio Inc., Hayward, CA, USA.
Jia Z; Ab Studio Inc., Hayward, CA, USA.
Wang B; Ab Studio Inc., Hayward, CA, USA.
Gallolu Kankanamalage S; Ab Studio Inc., Hayward, CA, USA.
Titong A; Ab Studio Inc., Hayward, CA, USA.
Liu Y; Ab Studio Inc., Hayward, CA, USA.; Ab Therapeutics Inc., Hayward, CA, USA.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2020 Dec; Vol. 9 (1), pp. 1034-1036.
Typ publikacji :
Letter
MeSH Terms :
Angiotensin Receptor Antagonists/*immunology
Antibodies, Monoclonal, Humanized/*immunology
Antibodies, Viral/*immunology
Betacoronavirus/*immunology
Camelids, New World/*immunology
Peptidyl-Dipeptidase A/*immunology
Angiotensin-Converting Enzyme 2 ; Animals ; Antibodies, Bispecific/immunology ; Humans ; Peptidyl-Dipeptidase A/metabolism ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/immunology
Opinia redakcyjna
Tytuł :
Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus.
Autorzy :
Wang N; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Han S; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Liu R; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Meng L; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, West Yanta Road No.76, Xi'an, Shaanxi 710061, China; The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an, Shaanxi 710004, China.
He H; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Zhang Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Wang C; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Lv Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Wang J; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Li X; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, West Yanta Road No.76, Xi'an, Shaanxi 710061, China; The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an, Shaanxi 710004, China.
Ding Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Fu J; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Hou Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Lu W; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Ma W; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Zhan Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Dai B; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Zhang J; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Pan X; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Hu S; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Gao J; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Jia Q; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Zhang L; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Ge S; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Wang S; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Liang P; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Hu T; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Lu J; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Wang X; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Zhou H; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Ta W; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Wang Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China.
Lu S; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, West Yanta Road No.76, Xi'an, Shaanxi 710061, China; The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an, Shaanxi 710004, China. Electronic address: .
He L; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, 710061, China; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi,710116, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2020 Dec; Vol. 79, pp. 153333. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme Inhibitors/*pharmacology
Betacoronavirus/*drug effects
Chloroquine/*pharmacology
Hydroxychloroquine/*pharmacology
Peptidyl-Dipeptidase A/*drug effects
Angiotensin-Converting Enzyme 2 ; Autophagy/drug effects ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/drug therapy ; HEK293 Cells ; Humans ; Molecular Docking Simulation ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Collaborative optimization and molecular docking exploration of novel ACE-inhibitory peptides from bovine milk by complex proteases hydrolysis.
Autorzy :
Chen L; College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, PR China.
Shangguan W; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, PR China.
Bao C; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, PR China.
Shu G; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, PR China.
Chen H; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, PR China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 180-187.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Milk/*chemistry
Peptide Fragments/*metabolism
Peptide Fragments/*pharmacology
Peptidyl-Dipeptidase A/*metabolism
Subtilisins/*metabolism
Angiotensin-Converting Enzyme Inhibitors/metabolism ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Cattle ; Hydrolysis ; Peptidyl-Dipeptidase A/chemistry ; Protein Conformation
Czasopismo naukowe
Tytuł :
A molecular docking study revealed that synthetic peptides induced conformational changes in the structure of SARS-CoV-2 spike glycoprotein, disrupting the interaction with human ACE2 receptor.
Autorzy :
Souza PFN; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará CEP 60.440-554, Brazil. Electronic address: .
Lopes FES; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará CEP 60.440-554, Brazil.
Amaral JL; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará CEP 60.440-554, Brazil.
Freitas CDT; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará CEP 60.440-554, Brazil.
Oliveira JTA; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará CEP 60.440-554, Brazil.
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Dec 01; Vol. 164, pp. 66-76. Date of Electronic Publication: 2020 Jul 18.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Betacoronavirus/*chemistry
Coronavirus Infections/*drug therapy
Peptides/*pharmacology
Peptidyl-Dipeptidase A/*chemistry
Pneumonia, Viral/*drug therapy
Spike Glycoprotein, Coronavirus/*chemistry
Angiotensin-Converting Enzyme 2 ; Antiviral Agents/chemistry ; Betacoronavirus/drug effects ; Betacoronavirus/metabolism ; Binding Sites/drug effects ; COVID-19 ; Computational Biology ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Humans ; Molecular Docking Simulation ; Pandemics ; Peptides/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; Protein Binding/drug effects ; Protein Conformation/drug effects ; Protein Interaction Domains and Motifs/drug effects ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł :
Virtual screening and molecular dynamics study of approved drugs as inhibitors of spike protein S1 domain and ACE2 interaction in SARS-CoV-2.
Autorzy :
Prajapat M; Dept. of Pharmacology, PGIMER, Chandigarh, India. Electronic address: .
Shekhar N; Dept. of Pharmacology, PGIMER, Chandigarh, India. Electronic address: .
Sarma P; Dept. of Pharmacology, PGIMER, Chandigarh, India. Electronic address: .
Avti P; Dept. of Biophysics, PGIMER, Chandigarh, India. Electronic address: .
Singh S; Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, India. Electronic address: .
Kaur H; Dept. of Pharmacology, PGIMER, Chandigarh, India. Electronic address: .
Bhattacharyya A; Dept. of Ophthalmology, GMCH-32, Chandigarh, India. Electronic address: .
Kumar S; Dept. of Pharmacology, PGIMER, Chandigarh, India. Electronic address: .
Sharma S; Dept. of Pharmacology, PGIMER, Chandigarh, India. Electronic address: .
Prakash A; Dept. of Pharmacology, PGIMER, Chandigarh, India. Electronic address: .
Medhi B; Dept. of Pharmacology, PGIMER, Chandigarh, India. Electronic address: .
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Źródło :
Journal of molecular graphics & modelling [J Mol Graph Model] 2020 Dec; Vol. 101, pp. 107716. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Drug Evaluation, Preclinical/*methods
Peptidyl-Dipeptidase A/*metabolism
Protein Interaction Domains and Motifs/*drug effects
Spike Glycoprotein, Coronavirus/*metabolism
Angiotensin-Converting Enzyme 2 ; Antiviral Agents/chemistry ; Computer Simulation ; Databases, Pharmaceutical ; Host-Pathogen Interactions/drug effects ; Models, Molecular ; Molecular Dynamics Simulation ; Peptidyl-Dipeptidase A/chemistry ; Reproducibility of Results ; Spike Glycoprotein, Coronavirus/chemistry
Czasopismo naukowe

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