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Tytuł :
Unified model of short- and long-term HIV viral rebound for clinical trial planning.
Autorzy :
Conway JM; Department of Mathematics and Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA, USA.
Meily P; University of Pennsylvania School of Arts and Sciences, Philadephia, PA, USA.
Li JZ; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA.
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Źródło :
Journal of the Royal Society, Interface [J R Soc Interface] 2021 Apr; Vol. 18 (177), pp. 20201015. Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Anti-HIV Agents*/therapeutic use
HIV Infections*/drug therapy
Antiretroviral Therapy, Highly Active ; Humans ; Time Factors ; Viral Load
Czasopismo naukowe
Tytuł :
HIV influences clustering and intracellular replication of hepatitis C virus.
Autorzy :
Goyal A; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA.
Kandathil AJ; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Quinn J; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Balagopal A; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Ribeiro RM; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA.; Laboratório de Biomatemática and Instituto de Saúde Ambiental, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
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Źródło :
Journal of viral hepatitis [J Viral Hepat] 2021 Feb; Vol. 28 (2), pp. 334-344. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Coinfection*
HIV Infections*/complications
Hepatitis C*/complications
Hepatitis C, Chronic*
Cluster Analysis ; Hepacivirus ; Humans
Czasopismo naukowe
Tytuł :
Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody.
Autorzy :
Asokan M; Virology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892; .
Dias J; Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Liu C; Virology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Maximova A; Virology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Ernste K; Virology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Pegu A; Virology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
McKee K; Virology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Shi W; Virology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Chen X; Virology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Almasri C; Virology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Promsote W; Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Ambrozak DR; Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Gama L; Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Hu J; Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Douek DC; Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Todd JP; Translational Research Program, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Lifson JD; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21701.
Fourati S; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106.
Sekaly RP; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106.
Crowley AR; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755.
Ackerman ME; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755.
Ko SH; Virus Persistence and Dynamics Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Kilam D; Virus Persistence and Dynamics Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Boritz EA; Virus Persistence and Dynamics Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Liao LE; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545.
Best K; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545.
Mascola JR; Virology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Koup RA; Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 04; Vol. 117 (31), pp. 18754-18763. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
HIV Infections*/immunology
HIV Infections*/virology
Antibodies, Neutralizing/*immunology
HIV Antibodies/*immunology
HIV-1/*immunology
Receptors, IgG/*immunology
Animals ; Antibody-Dependent Cell Cytotoxicity/immunology ; Cells, Cultured ; Disease Models, Animal ; Humans ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/virology ; Macaca mulatta ; Simian Acquired Immunodeficiency Syndrome ; Simian Immunodeficiency Virus
Czasopismo naukowe
Tytuł :
Quantifying the contribution of Fc-mediated effector functions to the antiviral activity of anti-HIV-1 IgG1 antibodies in vivo.
Autorzy :
Wang P; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032.
Gajjar MR; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032.
Yu J; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032.
Padte NN; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032.
Gettie A; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032.
Blanchard JL; Tulane National Primate Research Center, Tulane University, Covington, LA 70433.
Russell-Lodrigue K; Tulane National Primate Research Center, Tulane University, Covington, LA 70433.
Liao LE; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545.
Huang Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032.
Ho DD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 28; Vol. 117 (30), pp. 18002-18009. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
HIV Antibodies/*immunology
HIV Infections/*immunology
HIV Infections/*metabolism
HIV-1/*immunology
Immunoglobulin G/*immunology
Receptors, IgG/*metabolism
Animals ; Antibodies, Neutralizing/immunology ; Disease Models, Animal ; HIV Infections/virology ; Host-Pathogen Interactions/immunology ; Humans ; Mice ; Mice, Transgenic ; Neutralization Tests
Czasopismo naukowe
Tytuł :
Continuous and discrete modeling of HIV-1 decline on therapy.
Autorzy :
Akın E; Department of Mathematics and Statistics, Missouri S & T, Rolla, MO, 65409, USA.
Yeni G; Department of Mathematics and Statistics, Missouri S & T, Rolla, MO, 65409, USA.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA. .
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Źródło :
Journal of mathematical biology [J Math Biol] 2020 Jul; Vol. 81 (1), pp. 1-24. Date of Electronic Publication: 2020 Jun 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Anti-HIV Agents*/therapeutic use
HIV Infections*/drug therapy
HIV-1*
Models, Biological*
HIV Protease Inhibitors/therapeutic use ; Humans
Czasopismo naukowe
Tytuł :
Accumulated mutations by 6 months of infection collectively render transmitted/founder HIV-1 significantly less fit.
Autorzy :
Wang C; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, Jilin, China; Department of Medicine and Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.
Liu D; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, Jilin, China; Department of Medicine and Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA; Division of the Second in Vitro Diagnostic, National Institute for Food and Drug Control, Beijing 100050, China.
Zuo T; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, Jilin, China; Department of Medicine and Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.
Hora B; Department of Medicine and Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.
Cai F; Department of Medicine and Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.
Ding H; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Kappes J; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Ochsenbauer C; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Kong W; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, Jilin, China.
Yu X; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, Jilin, China.
Bhattacharya T; Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Perelson AS; Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Gao F; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, Jilin, China; Department of Medicine and Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: .
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Źródło :
The Journal of infection [J Infect] 2020 Feb; Vol. 80 (2), pp. 210-218. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
HIV Infections*
HIV Seropositivity*
HIV-1*/genetics
Humans ; Mutation ; Viral Load ; Virus Replication
Czasopismo naukowe
Tytuł :
Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread.
Autorzy :
Hataye JM; Immunology Section, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Electronic address: .
Casazza JP; Immunology Section, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
Best K; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Liang CJ; Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Rockville, MD 20892, USA.
Immonen TT; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Ambrozak DR; Immunology Section, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
Darko S; Human Immunology Section, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
Henry AR; Human Immunology Section, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
Laboune F; Human Immunology Section, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
Maldarelli F; HIV Dynamics and Replication Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Douek DC; Human Immunology Section, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
Hengartner NW; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Yamamoto T; Laboratory of Immunosenescence, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka 567-0085, Japan.
Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Koup RA; Immunology Section, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2019 Dec 11; Vol. 26 (6), pp. 748-763.e20. Date of Electronic Publication: 2019 Nov 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
HIV-1*/growth & development
HIV-1*/metabolism
HIV Infections/*epidemiology
CD4-Positive T-Lymphocytes/virology ; HIV Infections/transmission ; Humans ; Models, Biological ; Population Dynamics/statistics & numerical data ; Viral Load ; Virus Activation ; Virus Latency ; Virus Replication
Czasopismo naukowe
Tytuł :
Predictions of time to HIV viral rebound following ART suspension that incorporate personal biomarkers.
Autorzy :
Conway JM; Department of Mathematics and Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, Pennsylvania, United States of America.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Li JZ; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2019 Jul 24; Vol. 15 (7), pp. e1007229. Date of Electronic Publication: 2019 Jul 24 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Models, Biological*
Anti-HIV Agents/*administration & dosage
HIV Infections/*drug therapy
HIV Infections/*virology
Algorithms ; Biomarkers/blood ; Computational Biology ; HIV Infections/immunology ; Humans ; Likelihood Functions ; RNA, Viral/blood ; Stochastic Processes ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/virology ; Time Factors ; Viral Load/drug effects ; Viremia/drug therapy ; Viremia/immunology ; Viremia/virology ; Virus Latency/drug effects ; Virus Latency/immunology ; Withholding Treatment
Czasopismo naukowe
Tytuł :
Modeling the Effects of Morphine-Altered Virus Specific Antibody Responses on HIV/SIV Dynamics.
Autorzy :
Mutua JM; Department of Computer Science, Mathematics and Physics, Missouri Western State University, St. Joseph, Missouri, USA.
Perelson AS; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Kumar A; Division of Pharmacology, School of Pharmacy, University of Missouri - Kansas City, Missouri, USA.
Vaidya NK; Department of Mathematics and Statistics, San Diego State University, San Diego, California, USA. .; Computational Science Research Center, San Diego State University, San Diego, California, USA. .; Viral Information Institute, San Diego State Universtiy, San Diego, California, USA. .
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Źródło :
Scientific reports [Sci Rep] 2019 Apr 01; Vol. 9 (1), pp. 5423. Date of Electronic Publication: 2019 Apr 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Viral/*immunology
Antibody Formation/*drug effects
HIV Infections/*immunology
Morphine/*pharmacology
Simian Acquired Immunodeficiency Syndrome/*immunology
Simian Immunodeficiency Virus/*immunology
Algorithms ; Analgesics, Opioid/pharmacology ; Animals ; Antibody Formation/immunology ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; HIV Infections/virology ; Humans ; Macaca mulatta ; Male ; Models, Theoretical ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/physiology ; Virus Replication/drug effects ; Virus Replication/immunology
Czasopismo naukowe
Tytuł :
Probabilistic control of HIV latency and transactivation by the Tat gene circuit.
Autorzy :
Cao Y; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545; .; Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545.
Lei X; Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607.
Ribeiro RM; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545.; Laboratório de Biomatemática, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545.
Liang J; Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Dec 04; Vol. 115 (49), pp. 12453-12458. Date of Electronic Publication: 2018 Nov 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Viral/*physiology
HIV Infections/*virology
HIV-1/*physiology
Virus Latency/*physiology
tat Gene Products, Human Immunodeficiency Virus/*metabolism
Anti-HIV Agents/pharmacology ; Gene Regulatory Networks ; HIV Infections/drug therapy ; HIV-1/genetics ; Humans ; Signal Transduction ; Transcriptional Activation ; tat Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Determinants of the efficacy of HIV latency-reversing agents and implications for drug and treatment design.
Autorzy :
Ke R; Department of Mathematics, North Carolina State University, Raleigh, North Carolina, USA.; Theoretical Biology and Biophysics Group, MS-K710, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Conway JM; Department of Mathematics and Center for Infectious Disease Dynamics, Pennsylvania State University, State College, Pennsylvania, USA.
Margolis DM; University of North Carolina (UNC) HIV Cure Center, UNC Institute of Global Health and Infectious Diseases.; Departments of Medicine, Microbiology and Immunology, UNC Chapel Hill School of Medicine, and.; Department of Epidemiology, UNC Chapel Hill School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Perelson AS; Theoretical Biology and Biophysics Group, MS-K710, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
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Źródło :
JCI insight [JCI Insight] 2018 Oct 18; Vol. 3 (20). Date of Electronic Publication: 2018 Oct 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Models, Biological*
Anti-HIV Agents/*pharmacology
HIV Infections/*drug therapy
HIV-1/*physiology
Virus Latency/*drug effects
Anti-HIV Agents/therapeutic use ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; Drug Design ; Drug Therapy, Combination/methods ; HIV Antigens/metabolism ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/drug effects ; Humans ; Pulse Therapy, Drug ; Treatment Outcome
Czasopismo naukowe
Tytuł :
No recovery of replication-competent HIV-1 from human liver macrophages.
Autorzy :
Kandathil AJ; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Sugawara S; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Goyal A; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Durand CM; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Quinn J; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Sachithanandham J; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Cameron AM; Department of Surgery, Johns Hopkins University, Baltimore, Maryland, USA.
Bailey JR; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Balagopal A; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2018 Oct 01; Vol. 128 (10), pp. 4501-4509. Date of Electronic Publication: 2018 Sep 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver*/metabolism
Liver*/pathology
Liver*/virology
Macrophages*/metabolism
Macrophages*/pathology
Macrophages*/virology
Virus Replication*
HIV Infections/*metabolism
HIV-1/*physiology
Adult ; Anti-Retroviral Agents/administration & dosage ; Female ; HIV Infections/drug therapy ; HIV Infections/pathology ; Humans ; Male ; Middle Aged ; Time Factors
Czasopismo naukowe
Tytuł :
Variation in cell-associated unspliced HIV RNA on antiretroviral therapy is associated with the circadian regulator brain-and-muscle-ARNT-like-1.
Autorzy :
Chang CC; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia.
Naranbhai V; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Stern J; The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital.
Roche M; The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital.; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.
Dantanarayana A; The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital.
Ke R; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Tennakoon S; The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital.
Solomon A; The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital.
Hoh R; School of Medicine.
Hartogensis W; Division of Biostatistics.
Hecht FM; Osher Center for Integrative Medicine, University of California San Francisco, San Francisco, California, USA.
Sikaris K; Melbourne Pathology.
Price DJ; The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Elliott JH; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia.
Deeks SG; School of Medicine.
Churchill M; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.
Cameron PU; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia.; The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital.
Hengartner N; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Perelson AS; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Lewin SR; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia.; The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital.
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Źródło :
AIDS (London, England) [AIDS] 2018 Sep 24; Vol. 32 (15), pp. 2119-2128.
Typ publikacji :
Clinical Trial; Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
ARNTL Transcription Factors/*biosynthesis
Anti-Retroviral Agents/*therapeutic use
Blood Cells/*virology
HIV/*growth & development
HIV Infections/*virology
RNA, Viral/*analysis
ARNTL Transcription Factors/genetics ; Cells, Cultured ; Female ; Gene Expression Profiling ; HIV Infections/drug therapy ; Host-Pathogen Interactions ; Humans ; Male ; Middle Aged ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies.
Autorzy :
Liu D; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin, China.; Department of Medicine, Duke Human Vaccine Institute, Duke University Medical Center, 303 Research Dr., 244 Sands Building, DUMC 102359, Durham, NC, 27710, USA.; Division II of In Vitro Diagnostics for Infectious Diseases, Institute for In Vitro Diagnostics Control, National Institutes for Food and Drug Control, Beijing, China.
Wang C; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin, China.; Department of Medicine, Duke Human Vaccine Institute, Duke University Medical Center, 303 Research Dr., 244 Sands Building, DUMC 102359, Durham, NC, 27710, USA.
Hora B; Department of Medicine, Duke Human Vaccine Institute, Duke University Medical Center, 303 Research Dr., 244 Sands Building, DUMC 102359, Durham, NC, 27710, USA.
Zuo T; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin, China.; Department of Medicine, Duke Human Vaccine Institute, Duke University Medical Center, 303 Research Dr., 244 Sands Building, DUMC 102359, Durham, NC, 27710, USA.
Goonetilleke N; Department of Microbiology, Immunology and Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Liu MKP; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, England, UK.
Berrong M; Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Ferrari G; Department of Surgery, Duke University Medical Center, Durham, NC, USA.
McMichael AJ; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, England, UK.
Bhattacharya T; Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA.
Perelson AS; Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA.
Gao F; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin, China. .; Department of Medicine, Duke Human Vaccine Institute, Duke University Medical Center, 303 Research Dr., 244 Sands Building, DUMC 102359, Durham, NC, 27710, USA. .
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Źródło :
Retrovirology [Retrovirology] 2017 Oct 10; Vol. 14 (1), pp. 46. Date of Electronic Publication: 2017 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Neutralizing/*immunology
CD8-Positive T-Lymphocytes/*immunology
Genome, Viral/*genetics
HIV Infections/*immunology
HIV-1/*genetics
gag Gene Products, Human Immunodeficiency Virus/*genetics
Cell Culture Techniques ; Enzyme-Linked Immunospot Assay ; Epitopes, T-Lymphocyte/immunology ; Genetic Fitness/genetics ; HIV Infections/virology ; HIV-1/immunology ; Humans ; Immune Evasion/genetics ; Mutation ; Selection, Genetic/genetics ; Virus Replication ; gag Gene Products, Human Immunodeficiency Virus/immunology
Czasopismo naukowe
Tytuł :
Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration.
Autorzy :
Cardozo EF; Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, United States of America.
Andrade A; The Johns Hopkins University, Baltimore, MD, United States of America.
Mellors JW; University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.
Kuritzkes DR; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America.
Perelson AS; Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, United States of America.
Ribeiro RM; Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, United States of America.; Laboratório de Biomatemática, Faculdade de Medicina, Universidade de Lisboa. Av. Professor Egas Moniz, 1649-028 Lisboa, Portugal.
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Źródło :
PLoS pathogens [PLoS Pathog] 2017 Jul 05; Vol. 13 (7), pp. e1006478. Date of Electronic Publication: 2017 Jul 05 (Print Publication: 2017).
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
HIV Infections/*drug therapy
HIV Infections/*virology
HIV-1/*drug effects
Integrase Inhibitors/*administration & dosage
RNA, Viral/*metabolism
Virus Integration/*drug effects
CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; HIV Infections/immunology ; HIV-1/chemistry ; HIV-1/genetics ; HIV-1/physiology ; Half-Life ; Humans ; RNA Stability/drug effects ; RNA, Viral/chemistry ; RNA, Viral/genetics ; Raltegravir Potassium/administration & dosage ; Viral Load/drug effects ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Transmission of Multiple HIV-1 Subtype C Transmitted/founder Viruses into the Same Recipients Was not Determined by Modest Phenotypic Differences.
Autorzy :
Song H; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Hora B; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Giorgi EE; Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Kumar A; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Cai F; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Bhattacharya T; Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Perelson AS; Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Gao F; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
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Źródło :
Scientific reports [Sci Rep] 2016 Dec 02; Vol. 6, pp. 38130. Date of Electronic Publication: 2016 Dec 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
HIV Infections/*virology
HIV-1/*classification
HIV-1/*genetics
Genetic Variation ; Genome, Viral ; HIV Infections/transmission ; HIV-1/physiology ; Humans ; Interferon-alpha/pharmacology ; Male ; Phenotype ; Receptors, CCR5/physiology ; Receptors, HIV/physiology ; Viral Tropism/genetics ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Modeling Viral Spread.
Autorzy :
Graw F; Center for Modelling and Simulation in the Biosciences, BioQuant Center, Heidelberg University, 69120 Heidelberg, Germany.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545; email: .
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Źródło :
Annual review of virology [Annu Rev Virol] 2016 Sep 29; Vol. 3 (1), pp. 555-572. Date of Electronic Publication: 2016 Aug 31.
Typ publikacji :
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Virus Internalization*
HIV Infections/*transmission
HIV-1/*pathogenicity
Hepacivirus/*pathogenicity
Hepatitis C/*transmission
HIV Infections/virology ; Hepatitis C/virology ; Humans ; Models, Biological
Czasopismo naukowe
Tytuł :
Molecular clock of HIV-1 envelope genes under early immune selection.
Autorzy :
Park SY; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 1450 Biggy Street, Los Angeles, CA, 90089, USA.
Love TM; Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, 14642, USA.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.
Mack WJ; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
Lee HY; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 1450 Biggy Street, Los Angeles, CA, 90089, USA. .
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Źródło :
Retrovirology [Retrovirology] 2016 Jun 01; Vol. 13 (1), pp. 38. Date of Electronic Publication: 2016 Jun 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Evolution, Molecular*
Selection, Genetic*
HIV Infections/*virology
HIV-1/*genetics
HIV-1/*immunology
env Gene Products, Human Immunodeficiency Virus/*genetics
env Gene Products, Human Immunodeficiency Virus/*immunology
Genes, env ; HIV Infections/transmission ; Humans ; Immunologic Surveillance ; Models, Genetic ; Mutation ; Phylogeny
Czasopismo naukowe
Tytuł :
SPMM: estimating infection duration of multivariant HIV-1 infections.
Autorzy :
Love TM; Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, 14642, USA.
Park SY; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, 90089, USA.
Giorgi EE; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA and.
Mack WJ; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90089, USA.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA and.
Lee HY; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA and.
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Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2016 May 01; Vol. 32 (9), pp. 1308-15. Date of Electronic Publication: 2015 Dec 31.
Typ publikacji :
Journal Article
MeSH Terms :
HIV Infections/*virology
HIV-1/*genetics
Genetic Variation ; HIV Infections/physiopathology ; Humans ; Models, Theoretical ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
Residual Viremia in Treated HIV+ Individuals.
Autorzy :
Conway JM; Department of Mathematics and Center for Infectious Disease Dynamics (CIDD), The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2016 Jan 06; Vol. 12 (1), pp. e1004677. Date of Electronic Publication: 2016 Jan 06 (Print Publication: 2016).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Models, Biological*
HIV Infections/*virology
HIV-1/*physiology
Viremia/*virology
Anti-Retroviral Agents/pharmacology ; Anti-Retroviral Agents/therapeutic use ; Computational Biology ; HIV Infections/drug therapy ; HIV-1/drug effects ; HIV-1/genetics ; Humans ; RNA, Viral/genetics ; Viral Load ; Viremia/drug therapy ; Virus Replication/genetics
Czasopismo naukowe

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