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    Wyświetlanie 1-16 z 16
    Tytuł:
    Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies.
    Autorzy:
    Zitzmann C; Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany.; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
    Dächert C; Research Group 'Dynamics of Early Viral Infection and the Innate Antiviral Response', Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Schmid B; Dept of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
    van der Schaar H; Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands.
    van Hemert M; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
    Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
    van Kuppeveld FJM; Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands.
    Bartenschlager R; Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands.; Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Center for Infection Research (DZIF), Heidelberg partner site, Heidelberg, Germany.
    Binder M; Research Group 'Dynamics of Early Viral Infection and the Innate Antiviral Response', Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Kaderali L; Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany.
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2023 Apr 04; Vol. 19 (4), pp. e1010423. Date of Electronic Publication: 2023 Apr 04 (Print Publication: 2023).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    RNA Viruses*
    Hepatitis C*
    Humans ; Antiviral Agents/pharmacology ; Virus Replication/physiology ; RNA, Viral/genetics ; Models, Theoretical
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    HIV influences clustering and intracellular replication of hepatitis C virus.
    Autorzy:
    Goyal A; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
    Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA.
    Kandathil AJ; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
    Quinn J; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
    Balagopal A; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
    Ribeiro RM; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA.; Laboratório de Biomatemática and Instituto de Saúde Ambiental, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
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    Źródło:
    Journal of viral hepatitis [J Viral Hepat] 2021 Feb; Vol. 28 (2), pp. 334-344. Date of Electronic Publication: 2020 Nov 24.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Coinfection*
    HIV Infections*/complications
    Hepatitis C*/complications
    Hepatitis C, Chronic*
    Cluster Analysis ; Hepacivirus ; Humans
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.
    Autorzy:
    Benzine T; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Brandt R; Department of Mathematics, North Carolina State University, Raleigh, North Carolina, United States of America.
    Lovell WC; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Yamane D; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Neddermann P; INGM -Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.
    De Francesco R; INGM -Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.
    Lemon SM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
    Ke R; Department of Mathematics, North Carolina State University, Raleigh, North Carolina, United States of America.
    McGivern DR; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
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    Źródło:
    PLoS pathogens [PLoS Pathog] 2017 Jun 08; Vol. 13 (6), pp. e1006343. Date of Electronic Publication: 2017 Jun 08 (Print Publication: 2017).
    Typ publikacji:
    Comparative Study; Journal Article
    MeSH Terms:
    Hepacivirus/*drug effects
    Hepacivirus/*physiology
    Hepatitis C/*virology
    Virus Replication/*drug effects
    Half-Life ; Hepacivirus/chemistry ; Hepacivirus/classification ; Humans ; Kinetics ; Viral Nonstructural Proteins/antagonists & inhibitors ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism ; Virus Assembly/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Inferring viral dynamics in chronically HCV infected patients from the spatial distribution of infected hepatocytes.
    Autorzy:
    Graw F; Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, United States of America; Center for Modeling and Simulation in the Biosciences, Heidelberg University, Heidelberg, Germany.
    Balagopal A; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.
    Kandathil AJ; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.
    Ray SC; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.
    Thomas DL; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.
    Ribeiro RM; Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, United States of America.
    Perelson AS; Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, United States of America.
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2014 Nov 13; Vol. 10 (11), pp. e1003934. Date of Electronic Publication: 2014 Nov 13 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Hepacivirus/*physiology
    Hepatitis C/*virology
    Hepatocytes/*virology
    Adult ; Algorithms ; Computational Biology ; Female ; Host-Pathogen Interactions ; Humans ; Laser Capture Microdissection ; Liver/cytology ; Liver/virology ; Male ; Middle Aged ; Models, Biological ; Single-Cell Analysis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A hepatitis C virus infection model with time-varying drug effectiveness: solution and analysis.
    Autorzy:
    Conway JM; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
    Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2014 Aug 07; Vol. 10 (8), pp. e1003769. Date of Electronic Publication: 2014 Aug 07 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Models, Biological*
    Antiviral Agents/*pharmacology
    Hepacivirus/*drug effects
    Hepatitis C/*virology
    Viral Load/*drug effects
    Antiviral Agents/therapeutic use ; Computational Biology ; Hepatitis C/drug therapy ; Humans
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Analysis of hepatitis C virus decline during treatment with the protease inhibitor danoprevir using a multiscale model.
    Autorzy:
    Rong L; Department of Mathematics and Statistics and Center for Biomedical Research, Oakland University, Rochester, Michigan, USA.
    Guedj J
    Dahari H
    Coffield DJ Jr
    Levi M
    Smith P
    Perelson AS
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2013; Vol. 9 (3), pp. e1002959. Date of Electronic Publication: 2013 Mar 14.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Models, Biological*
    Antiviral Agents/*therapeutic use
    Hepacivirus/*physiology
    Hepatitis C/*drug therapy
    Hepatitis C/*virology
    Lactams/*therapeutic use
    Sulfonamides/*therapeutic use
    Virus Replication/*drug effects
    Antiviral Agents/pharmacology ; Computational Biology ; Cyclopropanes ; Hepacivirus/genetics ; Humans ; Isoindoles ; Lactams/pharmacology ; Lactams, Macrocyclic ; Proline/analogs & derivatives ; RNA, Viral/analysis ; RNA, Viral/metabolism ; Sulfonamides/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Spontaneous clearance of viral infections by mesoscopic fluctuations.
    Autorzy:
    Chaudhury S; Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America. />Perelson AS
    Sinitstyn NA
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    Źródło:
    PloS one [PLoS One] 2012; Vol. 7 (6), pp. e38549. Date of Electronic Publication: 2012 Jun 05.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    HIV Infections/*virology
    Hepatitis C/*virology
    HIV-1/pathogenicity ; Hepacivirus/pathogenicity ; Humans ; Models, Theoretical ; Viral Load
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Elucidation of hepatitis C virus transmission and early diversification by single genome sequencing.
    Autorzy:
    Li H; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
    Stoddard MB
    Wang S
    Blair LM
    Giorgi EE
    Parrish EH
    Learn GH
    Hraber P
    Goepfert PA
    Saag MS
    Denny TN
    Haynes BF
    Hahn BH
    Ribeiro RM
    Perelson AS
    Korber BT
    Bhattacharya T
    Shaw GM
    Pokaż więcej
    Źródło:
    PLoS pathogens [PLoS Pathog] 2012; Vol. 8 (8), pp. e1002880. Date of Electronic Publication: 2012 Aug 23.
    Typ publikacji:
    Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Host-Pathogen Interactions*
    Sequence Analysis, RNA*
    Genome, Viral/*genetics
    Hepacivirus/*physiology
    Hepatitis C/*genetics
    Hepatitis C/*transmission
    RNA, Viral/*genetics
    Acute Disease ; Female ; Genome, Viral/immunology ; Hepatitis C/immunology ; Humans ; Male ; RNA, Viral/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Quantifying the diversification of hepatitis C virus (HCV) during primary infection: estimates of the in vivo mutation rate.
    Autorzy:
    Ribeiro RM; Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
    Li H
    Wang S
    Stoddard MB
    Learn GH
    Korber BT
    Bhattacharya T
    Guedj J
    Parrish EH
    Hahn BH
    Shaw GM
    Perelson AS
    Pokaż więcej
    Źródło:
    PLoS pathogens [PLoS Pathog] 2012; Vol. 8 (8), pp. e1002881. Date of Electronic Publication: 2012 Aug 23.
    Typ publikacji:
    Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Models, Biological*
    Mutation Rate*
    Hepacivirus/*genetics
    Hepatitis C/*genetics
    Acute Disease ; Female ; Humans ; Male ; Time Factors ; Viral Load/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Modelling how ribavirin improves interferon response rates in hepatitis C virus infection.
    Autorzy:
    Dixit NM; Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.
    Layden-Almer JE
    Layden TJ
    Perelson AS
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    Źródło:
    Nature [Nature] 2004 Dec 16; Vol. 432 (7019), pp. 922-4.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
    MeSH Terms:
    Hepacivirus/*drug effects
    Hepatitis C/*drug therapy
    Hepatitis C/*virology
    Interferons/*pharmacology
    Interferons/*therapeutic use
    Ribavirin/*pharmacology
    Ribavirin/*therapeutic use
    Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Hepacivirus/genetics ; Hepacivirus/physiology ; Humans ; Models, Biological ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Viral Load
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis.
    Autorzy:
    Ramratnam, Bharat
    Bonhoeffer, Sebastian
    Binley, James
    Hurley, Arlene
    Zhang, Linqi
    Mittler, John E.
    Markowitz, Martin
    Moore, John P.
    Perelson, Alan S.
    Ho, David D.
    Pokaż więcej
    Temat:
    HIV
    HEMAPHERESIS
    VIRUS diseases
    HEPATITIS C
    PATHOLOGY
    Źródło:
    Lancet. 11/20/1999, Vol. 354 Issue 9192, p1782-1785. 4p. 1 Chart, 8 Graphs.
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-16 z 16

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