Benefits of Aldosterone Receptor Antagonism in Chronic Kidney Disease (BARACK D) trial-a multi-centre, prospective, randomised, open, blinded end-point, 36-month study of 2,616 patients within primary care with stage 3b chronic kidney disease to compare the efficacy of spironolactone 25 mg once daily in addition to routine care on mortality and cardiovascular outcomes versus routine care alone: study protocol for a randomized controlled trial.
Patient consultation rate and clinical and NHS outcomes: a cross-sectional analysis of English primary care data from 2.7 million patients in 238 practices.
Autorzy:
Lay-Flurrie S; Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK. . Mathieu E; Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK. Bankhead C; Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK. Nicholson BD; Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK. Perera-SalazarR; Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK. Holt T; Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK. Hobbs FDR; Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK. . Salisbury C; Centre for Academic Primary Care, Bristol Medical School, University of Bristol, Bristol, UK.
The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort.
Autorzy:
Nowakowska M; NIHR School for Primary Care Research, Centre for Primary Care and Health Services Research, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK. .; Division of Population Health, Health Services Research & Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK. . Zghebi SS; NIHR School for Primary Care Research, Centre for Primary Care and Health Services Research, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK.; Division of Population Health, Health Services Research & Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK. Ashcroft DM; NIHR School for Primary Care Research, Centre for Primary Care and Health Services Research, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK.; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, Manchester, M13 9PL, UK.; NIHR Greater Manchester Patient Safety Translational Research Centre, University of Manchester, Manchester, M13 9PL, UK. Buchan I; Division of Informatics, Imaging, and Data Science, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, Manchester, M13 9PL, UK.; Department of Public Health and Policy, Institute of Population Health Sciences, University of Liverpool, Liverpool, L69 3BX, UK. Chew-Graham C; Research Institute for Primary Care and Health Sciences, Faculty of Medicine and Health Sciences, Keele University, DJW 1.54a, Staffordshire, ST5 5BJ, UK. Holt T; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK. Mallen C; Research Institute for Primary Care and Health Sciences, Faculty of Medicine and Health Sciences, Keele University, DJW 1.54a, Staffordshire, ST5 5BJ, UK. Van Marwijk H; Division of Primary Care and Public Health, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9PH, UK. Peek N; NIHR Greater Manchester Patient Safety Translational Research Centre, University of Manchester, Manchester, M13 9PL, UK.; Division of Informatics, Imaging, and Data Science, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, Manchester, M13 9PL, UK.; NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre (MAHSC), University of Manchester, Manchester, M13 9PL, UK. Perera-SalazarR; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK. Reeves D; NIHR School for Primary Care Research, Centre for Primary Care and Health Services Research, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK.; Division of Population Health, Health Services Research & Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK.; Centre for Biostatistics, Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK. Rutter MK; Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, M13 9PL, UK.; Manchester Diabetes Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, M13 0JE, UK. Weng SF; Primary Care Stratified Medicine (PRISM), Division of Primary Care, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK. Qureshi N; Primary Care Stratified Medicine (PRISM), Division of Primary Care, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK. Mamas MA; Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University, Stoke-on-Trent, ST4 7QB, UK. Kontopantelis E; NIHR School for Primary Care Research, Centre for Primary Care and Health Services Research, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK.; Division of Population Health, Health Services Research & Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK.; Division of Informatics, Imaging, and Data Science, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, Manchester, M13 9PL, UK.
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Źródło:
BMC medicine [BMC Med] 2019 Jul 25; Vol. 17 (1), pp. 145. Date of Electronic Publication: 2019 Jul 25.
Correction to: The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort.
Autorzy:
Nowakowska M; NIHR School for Primary Care Research, Centre for Primary Care and Health Services Research, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK. .; Division of Population Health, Health Services Research & Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK. . Zghebi SS; NIHR School for Primary Care Research, Centre for Primary Care and Health Services Research, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK.; Division of Population Health, Health Services Research & Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK. Ashcroft DM; NIHR School for Primary Care Research, Centre for Primary Care and Health Services Research, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK.; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, Manchester, M13 9PL, UK.; NIHR Greater Manchester Patient Safety Translational Research Centre, University of Manchester, Manchester, M13 9PL, UK. Buchan I; Division of Informatics, Imaging, and Data Science, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, Manchester, M13 9PL, UK.; Department of Public Health and Policy, Institute of Population Health Sciences, University of Liverpool, Liverpool, L69 3BX, UK. Chew-Graham C; Research Institute for Primary Care and Health Sciences, Faculty of Medicine and Health Sciences, Keele University, DJW 1.54a, Staffordshire, ST5 5BJ, UK. Holt T; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK. Mallen C; Research Institute for Primary Care and Health Sciences, Faculty of Medicine and Health Sciences, Keele University, DJW 1.54a, Staffordshire, ST5 5BJ, UK. Van Marwijk H; Division of Primary Care and Public Health, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9PH, UK. Peek N; NIHR Greater Manchester Patient Safety Translational Research Centre, University of Manchester, Manchester, M13 9PL, UK.; Division of Informatics, Imaging, and Data Science, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, Manchester, M13 9PL, UK.; NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre (MAHSC), University of Manchester, Manchester, M13 9PL, UK. Perera-SalazarR; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Reeves D; NIHR School for Primary Care Research, Centre for Primary Care and Health Services Research, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK.; Division of Population Health, Health Services Research & Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK.; Centre for Biostatistics, Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK. Rutter MK; Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, M13 9PL, UK.; Manchester Diabetes Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, M13 0JE, UK. Weng SF; Primary Care Stratified Medicine (PRISM), Division of Primary Care, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK. Qureshi N; Primary Care Stratified Medicine (PRISM), Division of Primary Care, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK. Mamas MA; Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University, Stoke-on-Trent, ST4 7QB, UK. Kontopantelis E; NIHR School for Primary Care Research, Centre for Primary Care and Health Services Research, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK.; Division of Population Health, Health Services Research & Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, 5th floor Williamson Building, Manchester, M13 9PL, UK.; Division of Informatics, Imaging, and Data Science, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), University of Manchester, Manchester, M13 9PL, UK.
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Źródło:
BMC medicine [BMC Med] 2020 Jan 25; Vol. 18 (1), pp. 22. Date of Electronic Publication: 2020 Jan 25.
A randomised controlled trial of therapist-assisted online psychological therapies for posttraumatic stress disorder (STOP-PTSD): trial protocol.
Autorzy:
Ehlers A; Department of Experimental Psychology, University of Oxford, Paradise Square, Oxford, OX1 1TW, UK. .; Oxford Health NHS Foundation Trust, Oxford, OX3 7JX, UK. .; Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AF, UK. .; South London and Maudsley NHS Foundation Trust, London, SE5 8AZ, UK. . Wild J; Department of Experimental Psychology, University of Oxford, Paradise Square, Oxford, OX1 1TW, UK.; Oxford Health NHS Foundation Trust, Oxford, OX3 7JX, UK. Warnock-Parkes E; Department of Experimental Psychology, University of Oxford, Paradise Square, Oxford, OX1 1TW, UK.; Oxford Health NHS Foundation Trust, Oxford, OX3 7JX, UK.; Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AF, UK.; South London and Maudsley NHS Foundation Trust, London, SE5 8AZ, UK. Grey N; Sussex Partnership NHS Foundation Trust, Aldrington House, 35 New Church Road, Hove, BN3 4AG, UK. Murray H; Department of Experimental Psychology, University of Oxford, Paradise Square, Oxford, OX1 1TW, UK.; Oxford Health NHS Foundation Trust, Oxford, OX3 7JX, UK. Kerr A; Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AF, UK.; South London and Maudsley NHS Foundation Trust, London, SE5 8AZ, UK. Rozental A; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Norra Stationsgatan 69, 113 64, Stockholm, Sweden. Beierl ET; Department of Experimental Psychology, University of Oxford, Paradise Square, Oxford, OX1 1TW, UK.; Oxford Health NHS Foundation Trust, Oxford, OX3 7JX, UK. Tsiachristas A; Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK. Perera-SalazarR; Nuffield Department of Primary Care Health Sciences, Radcliffe Observatory Quarter, University of Oxford, Woodstock Road, Oxford, OX2 6GG, UK. Andersson G; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Norra Stationsgatan 69, 113 64, Stockholm, Sweden.; Department of Behavioural Sciences and Learning, Linköping University, 581 83, Linköping, Sweden. Clark DM; Department of Experimental Psychology, University of Oxford, Paradise Square, Oxford, OX1 1TW, UK.; Oxford Health NHS Foundation Trust, Oxford, OX3 7JX, UK.; Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AF, UK.; South London and Maudsley NHS Foundation Trust, London, SE5 8AZ, UK.
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Źródło:
Trials [Trials] 2020 Apr 23; Vol. 21 (1), pp. 355. Date of Electronic Publication: 2020 Apr 23.
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