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Tytuł :
Phase III Trial of Adjuvant Capecitabine After Standard Neo-/Adjuvant Chemotherapy in Patients With Early Triple-Negative Breast Cancer (GEICAM/2003-11_CIBOMA/2004-01).
Autorzy :
Lluch A; Hospital Clínico Universitario de Valencia and Biomedical Research Institute INCLIVA, University of Valencia, Valencia, Spain.; Centro de Investigación Biomédica en Red de Oncología ISCIII, Madrid, Spain.; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.
Barrios CH; Centro de Pesquisa Clínica Hospital São Lucas da PUCRS, Porto Alegre, Brazil.; LACOG, Latin American Cooperative Oncology Group, Porto Alegre, Brazil.
Torrecillas L; Centro Médico Nacional 20 de Noviembre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Ciudad de México, México.
Ruiz-Borrego M; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Hospital Universitario Virgen del Rocío, Sevilla, Spain.
Bines J; LACOG, Latin American Cooperative Oncology Group, Porto Alegre, Brazil.; Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
Segalla J; LACOG, Latin American Cooperative Oncology Group, Porto Alegre, Brazil.; Hospital Amaral Carvalho, Sao Paolo, Brazil.
Guerrero-Zotano Á; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Instituto Valenciano de Oncología, Valencia, Spain.
García-Sáenz JA; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Hospital Clínico San Carlos, Madrid, Spain.
Torres R; Instituto Nacional del Cáncer, Santiago, Chile.
de la Haba J; Centro de Investigación Biomédica en Red de Oncología ISCIII, Madrid, Spain.; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Hospital Universitario Reina Sofía, Córdoba, Spain.
García-Martínez E; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Hospital General Universitario Morales Meseguer, Murcia, Spain.
Gómez HL; Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú.; GECOPERU, Peruvian Oncological Clinical Studies Group, Lima, Peru.
Llombart A; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Hospital Arnau de Vilanova, Lleida, Spain.
Bofill JS; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Hospital Universitario Na Sa de Valme, Sevilla, Spain.
Baena-Cañada JM; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Hospital Universitario Puerta del Mar and Instituto de Investigación e Innovación Biomédica de Cádiz, Cádiz, Spain.
Barnadas A; Centro de Investigación Biomédica en Red de Oncología ISCIII, Madrid, Spain.; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Hospital de la Santa Creu i Sant Pau, Medicine Department Universitat Autonoma, Institut Recerca Biomedica Sant Pau, Barcelona, Spain.
Calvo L; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Complexo Hospitalario Universitario A Coruña, A Coruña, Spain.
Pérez-Michel L; Hospital de San José, Ciudad Obregón, Sonora, México.
Ramos M; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Centro Oncológico de Galicia, A Coruña, Spain.
Fernández I; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
Rodríguez-Lescure Á; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Hospital General Universitario de Elche, Alicante, Spain.
Cárdenas J; Centro Médico Colima, Colima, México.
Vinholes J; LACOG, Latin American Cooperative Oncology Group, Porto Alegre, Brazil.; Unidade de Novos Tratamentos CliniOnco, Porto Alegre, Brazil.
Martínez de Dueñas E; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Consorcio Hospitalario Provincial de Castellón, Castellón, Spain.
Godes MJ; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Hospital General Universitario de Valencia, Valencia, Spain.
Seguí MA; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Corporació Sanitaria Parc Taulí de Sabadell, Barcelona, Spain.
Antón A; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Instituto de Investigación Sanitaria Aragon, Hospital Universitario Miguel Servet, Zaragoza, Spain.
López-Álvarez P; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain.
Moncayo J; Social S Hospital Teodoro Maldonado Carbo, Guayaquil, Ecuador.
Amorim G; LACOG, Latin American Cooperative Oncology Group, Porto Alegre, Brazil.; Oncologistas Associados-Oncologia D'Or, Rio de Janeiro, Brazil.
Villar E; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Hospital Regional Universitario Carlos Haya, Málaga, Spain.
Reyes S; Hospital Beneficiencia Española, San Luis de Potosí, México.
Sampaio C; LACOG, Latin American Cooperative Oncology Group, Porto Alegre, Brazil.; Clínica Amo Itaigara, Salvador, Brazil.
Cardemil B; Hospital Base de Valdivia, Valdivia, Chile.
Escudero MJ; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.
Bezares S; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.
Carrasco E; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.
Martín M; Centro de Investigación Biomédica en Red de Oncología ISCIII, Madrid, Spain.; GEICAM, Spanish Breast Cancer Group, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, Madrid, Spain.
Pokaż więcej
Corporate Authors :
GEICAM Spanish Breast Cancer Group
CIBOMA (Iberoamerican Coalition for Research in Breast Oncology)
LACOG (Latin American Cooperative Oncology Group)
Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2020 Jan 20; Vol. 38 (3), pp. 203-213. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial
MeSH Terms :
Antimetabolites, Antineoplastic/*therapeutic use
Capecitabine/*therapeutic use
Chemotherapy, Adjuvant/*methods
Triple Negative Breast Neoplasms/*drug therapy
Adult ; Aged ; Disease-Free Survival ; Female ; Humans ; Middle Aged ; Neoadjuvant Therapy ; Young Adult
Czasopismo naukowe
Tytuł :
Efficacy of the Antibody-Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors.
Autorzy :
Akla B; Institut de Recherche Pierre Fabre, Centre d'Immunologie, Saint-Julien-en-Genevois, France.
Broussas M; Institut de Recherche Pierre Fabre, Centre d'Immunologie, Saint-Julien-en-Genevois, France.
Loukili N; Institut de Recherche Pierre Fabre, Centre d'Immunologie, Saint-Julien-en-Genevois, France.
Robert A; Institut de Recherche Pierre Fabre, Centre d'Immunologie, Saint-Julien-en-Genevois, France.
Beau-Larvor C; Institut de Recherche Pierre Fabre, Centre d'Immunologie, Saint-Julien-en-Genevois, France.
Malissard M; Institut de Recherche Pierre Fabre, Centre d'Immunologie, Saint-Julien-en-Genevois, France.
Boute N; Institut de Recherche Pierre Fabre, Centre d'Immunologie, Saint-Julien-en-Genevois, France.
Champion T; Institut de Recherche Pierre Fabre, Centre d'Immunologie, Saint-Julien-en-Genevois, France.
Haeuw JF; Institut de Recherche Pierre Fabre, Centre d'Immunologie, Saint-Julien-en-Genevois, France. .
Beck A; Institut de Recherche Pierre Fabre, Centre d'Immunologie, Saint-Julien-en-Genevois, France.
Perez M; Institut de Recherche Pierre Fabre, Oncology Innovation Unit, Toulouse, France.
Dreyfus C; Institut de Recherche Pierre Fabre, Centre d'Immunologie, Saint-Julien-en-Genevois, France.
Pavlyuk M; Institut de Recherche Pierre Fabre, Oncology Innovation Unit, Toulouse, France.
Chetaille E; Institut de Recherche Pierre Fabre, Oncology Innovation Unit, Toulouse, France.
Corvaia N; Institut de Recherche Pierre Fabre, Centre d'Immunologie, Saint-Julien-en-Genevois, France.
Pokaż więcej
Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2020 Jan; Vol. 19 (1), pp. 168-177. Date of Electronic Publication: 2019 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunoconjugates/*therapeutic use
Neoplasms/*drug therapy
Receptor, IGF Type 1/*antagonists & inhibitors
Animals ; Cell Line, Tumor ; Female ; Humans ; Immunoconjugates/pharmacology ; Mice ; Mice, Nude ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Phase Field Modelling of Abnormal Grain Growth.
Autorzy :
Liu Y; The Centre for Metallurgical Process Engineering, The University of British Columbia, Vancouver, BC V6T1Z4, Canada.
Militzer M; The Centre for Metallurgical Process Engineering, The University of British Columbia, Vancouver, BC V6T1Z4, Canada.
Perez M; MATEIS, UMR CNRS 5510, INSA Lyon, Univ. Lyon, F69621 Villeurbanne, France.
Pokaż więcej
Źródło :
Materials (Basel, Switzerland) [Materials (Basel)] 2019 Dec 05; Vol. 12 (24). Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Disentangling and Lamellar Thickening of Linear Polymers during Crystallization: Simulation of Bimodal and Unimodal Molecular Weight Distribution Systems.
Autorzy :
Zhai Z; Univ de Lyon, INSA Lyon , MATEIS, UMR CNRS 5510, 69621 Villeurbanne , France.
Fusco C; Univ de Lyon, INSA Lyon , MATEIS, UMR CNRS 5510, 69621 Villeurbanne , France.
Morthomas J; Univ de Lyon, INSA Lyon , MATEIS, UMR CNRS 5510, 69621 Villeurbanne , France.
Perez M; Univ de Lyon, INSA Lyon , MATEIS, UMR CNRS 5510, 69621 Villeurbanne , France.
Lame O; Univ de Lyon, INSA Lyon , MATEIS, UMR CNRS 5510, 69621 Villeurbanne , France.
Pokaż więcej
Źródło :
ACS nano [ACS Nano] 2019 Oct 22; Vol. 13 (10), pp. 11310-11319. Date of Electronic Publication: 2019 Oct 11.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Crystallization of finite-extensible nonlinear elastic Lennard-Jones coarse-grained polymers.
Autorzy :
Morthomas J; INSA de Lyon, Université de Lyon, MATEIS, UMR CNRS 5510, 69621 Villeurbanne, France.
Fusco C; INSA de Lyon, Université de Lyon, MATEIS, UMR CNRS 5510, 69621 Villeurbanne, France.
Zhai Z; INSA de Lyon, Université de Lyon, MATEIS, UMR CNRS 5510, 69621 Villeurbanne, France.
Lame O; INSA de Lyon, Université de Lyon, MATEIS, UMR CNRS 5510, 69621 Villeurbanne, France.
Perez M; INSA de Lyon, Université de Lyon, MATEIS, UMR CNRS 5510, 69621 Villeurbanne, France.
Pokaż więcej
Źródło :
Physical review. E [Phys Rev E] 2017 Nov; Vol. 96 (5-1), pp. 052502. Date of Electronic Publication: 2017 Nov 27.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Role of the Intercrystalline Tie Chains Network in the Mechanical Response of Semicrystalline Polymers.
Autorzy :
Jabbari-Farouji S; Institute of Physics, Johannes Gutenberg-University, Staudingerweg 7-9, 55128 Mainz, Germany.
Lame O; Université de Lyon, INSA, MATEIS, UMR CNRS 5510, F69621 Villeurbanne, France.
Perez M; Université de Lyon, INSA, MATEIS, UMR CNRS 5510, F69621 Villeurbanne, France.
Rottler J; Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, British Columbia V6T 1Z1, Canada.
Barrat JL; Université Grenoble Alpes, LIPHY, F-38000 Grenoble, France and CNRS, LIPHY, F-38000 Grenoble, France.
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Źródło :
Physical review letters [Phys Rev Lett] 2017 May 26; Vol. 118 (21), pp. 217802. Date of Electronic Publication: 2017 May 26.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
A sensitive multidimensional method for the detection, characterization, and quantification of trace free drug species in antibody-drug conjugate samples using mass spectral detection.
Autorzy :
Birdsall RE; a Waters Corporation, 34 Maple Street , Milford , MA , 01757 , USA.
McCarthy SM; a Waters Corporation, 34 Maple Street , Milford , MA , 01757 , USA.
Janin-Bussat MC; b IRPF, Center d'Immunologie Pierre Fabre , St Julien-en-Genevois , France.
Perez M; c IRPF, Center de R&D Pierre Fabre , Toulouse , France.
Haeuw JF; b IRPF, Center d'Immunologie Pierre Fabre , St Julien-en-Genevois , France.
Chen W; a Waters Corporation, 34 Maple Street , Milford , MA , 01757 , USA.
Beck A; b IRPF, Center d'Immunologie Pierre Fabre , St Julien-en-Genevois , France.
Pokaż więcej
Źródło :
MAbs [MAbs] 2016; Vol. 8 (2), pp. 306-17. Date of Electronic Publication: 2015 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcysteine/*chemistry
Fluorescent Dyes/*chemistry
Trastuzumab/*chemistry
Chromatography, Reverse-Phase ; Humans ; Mass Spectrometry ; Protein Stability
Czasopismo naukowe
Tytuł :
Correlation of structure and mechanical response in solid-like polymers.
Autorzy :
Jabbari-Farouji S; Université Grenoble Alpes, UJF Liphy, F38041 Grenoble, France.
Rottler J
Lame O
Makke A
Perez M
Barrat JL
Pokaż więcej
Źródło :
Journal of physics. Condensed matter : an Institute of Physics journal [J Phys Condens Matter] 2015 May 20; Vol. 27 (19), pp. 194131. Date of Electronic Publication: 2015 Apr 29.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
A novel method for calculating the energy barriers for carbon diffusion in ferrite under heterogeneous stress.
Autorzy :
Tchitchekova DS; IRS[N], PSN, SEMIA, LPTM, Saint-Paul-Lez-Durance, France.
Morthomas J; Univ. Lyon, INSA Lyon, MATEIS, UMR CNRS 5510, Villeurbanne, France.
Ribeiro F; IRS[N], PSN, SEMIA, LPTM, Saint-Paul-Lez-Durance, France.
Ducher R; IRS[N], PSN, SAG, LETR, Saint-Paul-Lez-Durance, France.
Perez M; Univ. Lyon, INSA Lyon, MATEIS, UMR CNRS 5510, Villeurbanne, France.
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Źródło :
The Journal of chemical physics [J Chem Phys] 2014 Jul 21; Vol. 141 (3), pp. 034118.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion.
Autorzy :
Wagner-Rousset E
Janin-Bussat MC
Colas O
Excoffier M
Ayoub D
Haeuw JF
Rilatt I
Perez M
Corvaïa N
Beck A
Pokaż więcej
Źródło :
MAbs [MAbs] 2014 Jan-Feb; Vol. 6 (1), pp. 273-85.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Chemical*
Proteolysis*
Antibodies, Monoclonal, Humanized/*chemistry
Cytotoxins/*chemistry
Dansyl Compounds/*chemistry
Immunoconjugates/*chemistry
Chromatography, Liquid/methods ; Cysteine/chemistry ; Humans ; Mass Spectrometry/methods ; Trastuzumab
Czasopismo naukowe
Tytuł :
Nanoscale buckling deformation in layered copolymer materials.
Autorzy :
Makke A; Universite de Lyon, University Lyon I, Laboratoire de Physique de la Matière Condensée et Nanostructures, Unité Mixte de Recherche 5586, Centre National de la Recherche Scientifique, 5586-F69622 Villeurbanne, France.
Perez M
Lame O
Barrat JL
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Jan 17; Vol. 109 (3), pp. 680-5. Date of Electronic Publication: 2011 Dec 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Protease-activated receptor-1 antagonist F 16618 reduces arterial restenosis by down-regulation of tumor necrosis factor α and matrix metalloproteinase 7 expression, migration, and proliferation of vascular smooth muscle cells.
Autorzy :
Chieng-Yane P; Institut de Recherche Pierre Fabre, Castres Cedex France.
Bocquet A
Létienne R
Bourbon T
Sablayrolles S
Perez M
Hatem SN
Lompré AM
Le Grand B
David-Dufilho M
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2011 Mar; Vol. 336 (3), pp. 643-51. Date of Electronic Publication: 2010 Dec 07.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Matrix Metalloproteinase Inhibitors*
Carotid Stenosis/*prevention & control
Cell Movement/*drug effects
Down-Regulation/*drug effects
Muscle, Smooth, Vascular/*drug effects
Piperazines/*pharmacology
Pyridines/*pharmacology
Receptor, PAR-1/*antagonists & inhibitors
Tumor Necrosis Factor-alpha/*antagonists & inhibitors
Animals ; Carotid Stenosis/metabolism ; Cell Movement/physiology ; Cell Proliferation/drug effects ; Cells, Cultured ; Coronary Restenosis/drug therapy ; Coronary Restenosis/metabolism ; Down-Regulation/physiology ; Gene Expression Regulation, Enzymologic ; Humans ; Male ; Matrix Metalloproteinase 7/biosynthesis ; Muscle, Smooth, Vascular/enzymology ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/enzymology ; Myocytes, Smooth Muscle/metabolism ; Piperazines/therapeutic use ; Pyridines/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Receptor, PAR-1/physiology ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Antithrombotic activity of F 16618, a new PAR1 antagonist evaluated in extracorporeal arterio-venous shunt in the rat.
Autorzy :
Létienne R; Centre de Recherche Pierre Fabre, Castres, France.
Leparq-Panissié A
Calmettes Y
Nadal-Wollbold F
Perez M
Le Grand B
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2010 Jun 01; Vol. 79 (11), pp. 1616-21. Date of Electronic Publication: 2010 Feb 25.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Fibrinolytic Agents/*therapeutic use
Piperazines/*pharmacology
Pyridines/*pharmacology
Receptor, PAR-1/*antagonists & inhibitors
Thrombosis/*drug therapy
Animals ; Arterial Occlusive Diseases/drug therapy ; Arteriovenous Shunt, Surgical ; Aspirin/administration & dosage ; Aspirin/pharmacology ; Bleeding Time ; Clopidogrel ; Dose-Response Relationship, Drug ; Fibrinolytic Agents/pharmacology ; Humans ; Male ; Piperazines/administration & dosage ; Piperazines/therapeutic use ; Platelet Aggregation/drug effects ; Pyridines/administration & dosage ; Pyridines/therapeutic use ; Rats ; Ticlopidine/administration & dosage ; Ticlopidine/analogs & derivatives ; Ticlopidine/pharmacology
Czasopismo naukowe
Tytuł :
Exploration of a new series of PAR1 antagonists.
Autorzy :
Planty B; Department of Medicinal Chemistry 4, Centre de Recherche Pierre Fabre, 17 Avenue Jean Moulin, 81106 Castres Cedex, France.
Pujol C
Lamothe M
Maraval C
Horn C
Le Grand B
Perez M
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Mar 01; Vol. 20 (5), pp. 1735-9. Date of Electronic Publication: 2010 Jan 20.
Typ publikacji :
Journal Article
MeSH Terms :
Fibrinolytic Agents/*chemistry
Piperidines/*chemistry
Pyridines/*chemistry
Receptor, PAR-1/*antagonists & inhibitors
Amino Acid Sequence ; Animals ; Disease Models, Animal ; Fibrinolytic Agents/chemical synthesis ; Fibrinolytic Agents/pharmacology ; Humans ; Peptides/metabolism ; Piperidines/chemical synthesis ; Piperidines/pharmacology ; Pyridines/chemical synthesis ; Pyridines/pharmacology ; Rats ; Receptor, PAR-1/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Discovery and SAR of small molecule PAR1 antagonists.
Autorzy :
Rilatt I; Department of Medicinal Chemistry 4, Centre de Recherche Pierre Fabre, 17 Avenue Jean Moulin, 81106 Castres Cedex, France. />Mirabel E
Le Grand B
Perez M
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Feb 01; Vol. 20 (3), pp. 903-6. Date of Electronic Publication: 2009 Dec 23.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Drug Discovery/*methods
Oligopeptides/*chemistry
Oligopeptides/*pharmacology
Receptor, PAR-1/*antagonists & inhibitors
Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Humans ; Microsomes, Liver/drug effects ; Microsomes, Liver/physiology ; Protease Inhibitors/chemistry ; Protease Inhibitors/pharmacology ; Rats ; Receptor, PAR-1/physiology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Discovery of novel protease activated receptors 1 antagonists with potent antithrombotic activity in vivo.
Autorzy :
Perez M; Medicinal Chemistry 4 Division, Pierre Fabre Research Center, Castres Cedex, France. michel.perez@pierre-fabre.com
Lamothe M
Maraval C
Mirabel E
Loubat C
Planty B
Horn C
Michaux J
Marrot S
Letienne R
Pignier C
Bocquet A
Nadal-Wollbold F
Cussac D
de Vries L
Le Grand B
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2009 Oct 08; Vol. 52 (19), pp. 5826-36.
Typ publikacji :
Journal Article
MeSH Terms :
Fibrinolytic Agents/*chemical synthesis
Platelet Aggregation Inhibitors/*chemical synthesis
Receptor, PAR-1/*antagonists & inhibitors
Animals ; Drug Discovery ; Drug-Related Side Effects and Adverse Reactions ; Fibrinolytic Agents/administration & dosage ; Humans ; Piperazines/pharmacology ; Platelet Aggregation Inhibitors/administration & dosage ; Platelet Aggregation Inhibitors/pharmacology ; Pyridines/pharmacology ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Mechanical testing of glassy and rubbery polymers in numerical simulations: role of boundary conditions in tensile stress experiments.
Autorzy :
Makke A; UMR 5586, CNRS, Laboratoire de Physique de la Matière Condensée et Nanostructures, Univ. Lyon I, Université de Lyon, 69622 Villeurbanne, France. />Perez M
Lame O
Barrat JL
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Źródło :
The Journal of chemical physics [J Chem Phys] 2009 Jul 07; Vol. 131 (1), pp. 014904.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Effects of a new PAR1 antagonist, F 16618, on smooth muscle cell contraction.
Autorzy :
Bocquet A; Centre de Recherche Pierre Fabre, Castres Cedex, France.
Létienne R
Sablayrolles S
De Vries L
Perez M
Le Grand B
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2009 Jun 02; Vol. 611 (1-3), pp. 60-3. Date of Electronic Publication: 2009 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Myocytes, Smooth Muscle/*drug effects
Myocytes, Smooth Muscle/*metabolism
Piperazines/*pharmacology
Pyridines/*pharmacology
Receptor, PAR-1/*antagonists & inhibitors
Anesthesia ; Animals ; CHO Cells ; Calcium/metabolism ; Coronary Vessels/drug effects ; Coronary Vessels/physiology ; Cricetinae ; Cricetulus ; Fluorescence ; Hemodynamics/drug effects ; Isometric Contraction/drug effects ; Male ; Mesenteric Artery, Superior/drug effects ; Mesenteric Artery, Superior/physiology ; Muscle Contraction/drug effects ; Oligopeptides/pharmacology ; Rats ; Reference Standards ; Swine
Czasopismo naukowe
Tytuł :
[Recurrence of breast cancer in women residing in northwestern Mexico].
Autorzy :
Pérez-Michel LM; Servicio de Oncología, Hospital General Regional 1, Ciudad Obregón, Sonora, Mexico.
González-Lizarraga M
Ornelas-Aguirre JM
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Transliterated Title :
Recurrencia de cáncer de mama en mujeres del Noroeste de México.
Źródło :
Cirugia y cirujanos [Cir Cir] 2009 May-Jun; Vol. 77 (3), pp. 179-85.
Typ publikacji :
English Abstract; Journal Article
MeSH Terms :
Breast Neoplasms/*epidemiology
Neoplasm Recurrence, Local/*epidemiology
Cross-Sectional Studies ; Female ; Humans ; Mexico/epidemiology ; Middle Aged ; Prevalence
Czasopismo naukowe

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