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Tytuł :
Preparation of Cytolysin A (ClyA) Nanopores.
Autorzy :
Galenkamp NS; Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.
Van Meervelt V; Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.
Mutter NL; Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.
van der Heide NJ; Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.
Wloka C; Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.
Maglia G; Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2186, pp. 11-18.
Typ publikacji :
Journal Article
MeSH Terms :
Nanopores*
Cytotoxins/*isolation & purification
Escherichia coli/*metabolism
Escherichia coli Proteins/*isolation & purification
Perforin/*isolation & purification
Cytotoxins/chemistry ; Cytotoxins/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/metabolism ; Perforin/chemistry ; Perforin/metabolism
Czasopismo naukowe
Tytuł :
Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients.
Autorzy :
Ishii K; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, and.; Experimental Transplantation and Immunotherapy Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.
Pouzolles M; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
Chien CD; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
Erwin-Cohen RA; Cancer and Inflammation Program, Center for Cancer Research, NCI, NIH, Frederick, Maryland, USA.
Kohler ME; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.; Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado, USA.
Qin H; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
Lei H; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
Kuhn S; CCR Collaborative Bioinformatics Resource (CCBR), Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Ombrello AK; Inflammatory Disease Section, National Human Genome Research Institute, NIH.
Dulau-Florea A; Department of Laboratory Medicine, NIH, and.
Eckhaus MA; Diagnostic and Research Services Branch, Division of Veterinary Resources, NIH, Bethesda, Maryland, USA.
Shalabi H; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
Yates B; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
Lichtenstein DA; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
Zimmermann VS; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.; Université de Montpellier, IGMM, CNRS, Montpellier, France.
Kondo T; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
Shern JF; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
Young HA; Cancer and Inflammation Program, Center for Cancer Research, NCI, NIH, Frederick, Maryland, USA.; Laboratory of Cancer Immunometabolism, Center for Cancer Research, NCI, NIH, Frederick, Maryland, USA.
Taylor N; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.; Université de Montpellier, IGMM, CNRS, Montpellier, France.
Shah NN; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
Fry TJ; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.; Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado, USA.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Oct 01; Vol. 130 (10), pp. 5425-5443.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Immunotherapy, Adoptive/*adverse effects
Perforin/*deficiency
Receptors, Chimeric Antigen/*immunology
T-Lymphocytes/*immunology
Animals ; Cytokines/biosynthesis ; Disease Models, Animal ; Humans ; In Vitro Techniques ; Inflammation Mediators/metabolism ; Lymphohistiocytosis, Hemophagocytic/etiology ; Lymphohistiocytosis, Hemophagocytic/immunology ; Lymphohistiocytosis, Hemophagocytic/pathology ; Macrophage Activation Syndrome/etiology ; Macrophage Activation Syndrome/immunology ; Macrophage Activation Syndrome/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Immunological ; Perforin/genetics ; T-Lymphocytes/pathology
Czasopismo naukowe
Tytuł :
COVID-19 pneumonia: CD8 T and NK cells are decreased in number but compensatory increased in cytotoxic potential.
Autorzy :
Jiang Y; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Wei X; Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
Guan J; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Qin S; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Wang Z; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Lu H; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Qian J; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Wu L; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Chen Y; Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou, Medical University, Wenzhou 325000, China.
Chen Y; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: .
Lin X; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: .
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Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2020 Sep; Vol. 218, pp. 108516. Date of Electronic Publication: 2020 Jun 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Betacoronavirus/*pathogenicity
Coronavirus Infections/*diagnosis
Granzymes/*genetics
Killer Cells, Natural/*immunology
Perforin/*genetics
Pneumonia, Viral/*diagnosis
T-Lymphocytes, Cytotoxic/*immunology
Aged ; Aged, 80 and over ; Betacoronavirus/immunology ; Biomarkers/blood ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/pathology ; CD4-Positive T-Lymphocytes/virology ; COVID-19 ; COVID-19 Testing ; Case-Control Studies ; China ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/blood ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Disease Progression ; Female ; Gene Expression ; Granzymes/blood ; Granzymes/immunology ; Humans ; Killer Cells, Natural/pathology ; Killer Cells, Natural/virology ; Lymphocyte Activation ; Lymphocyte Count ; Male ; Middle Aged ; Pandemics ; Perforin/blood ; Perforin/immunology ; Pneumonia, Viral/blood ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Prognosis ; ROC Curve ; SARS-CoV-2 ; Severity of Illness Index ; T-Lymphocytes, Cytotoxic/pathology ; T-Lymphocytes, Cytotoxic/virology
Czasopismo naukowe
Tytuł :
Perforins Expression by Cutaneous Gamma Delta T Cells.
Autorzy :
O'Neill K; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, United States.
Pastar I; Wound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL, United States.
Tomic-Canic M; Wound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL, United States.
Strbo N; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Aug 14; Vol. 11, pp. 1839. Date of Electronic Publication: 2020 Aug 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cytotoxicity, Immunologic/*immunology
Intraepithelial Lymphocytes/*immunology
Perforin/*immunology
Animals ; Humans ; Intraepithelial Lymphocytes/metabolism ; Perforin/biosynthesis
Czasopismo naukowe
Tytuł :
Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis.
Autorzy :
Jang HS; Immunorheumatology Laboratory, New South Wales Health Pathology, Royal North Shore Hospital, Sydney, Australia.; Department of Clinical Immunology and Allergy, Royal North Shore Hospital, Sydney, Australia.
Flinsenberg TWH; Cancer Immunology Program, Killer Cell Biology Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Lacaze P; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Thia KYT; Cancer Immunology Program, Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Noori T; Cancer Immunology Program, Killer Cell Biology Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Fernando SL; Immunorheumatology Laboratory, New South Wales Health Pathology, Royal North Shore Hospital, Sydney, Australia.; Department of Clinical Immunology and Allergy, Royal North Shore Hospital, Sydney, Australia.; The University of Sydney, Sydney, Australia.
Kerridge I; Department of Haematology, Royal North Shore Hospital, Sydney, Australia.
Riaz M; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
McNeil JJ; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Blombery PA; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Trapani JA; Cancer Immunology Program, Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.
Voskoboinik I; Cancer Immunology Program, Killer Cell Biology Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.
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Źródło :
British journal of haematology [Br J Haematol] 2020 Aug; Vol. 190 (3), pp. 458-461. Date of Electronic Publication: 2020 Apr 27.
Typ publikacji :
Case Reports; Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Killer Cells, Natural/*immunology
Lymphohistiocytosis, Hemophagocytic/*immunology
Perforin/*genetics
Epstein-Barr Virus Infections/complications ; Ferritins/blood ; Fibrinogen/analysis ; Hepatitis/etiology ; Homozygote ; Humans ; Loss of Function Mutation ; Lymphohistiocytosis, Hemophagocytic/etiology ; Male ; Mutation, Missense ; Perforin/immunology ; Young Adult
Raport
Tytuł :
An Ancient Molecular Arms Race: Chlamydia vs. Membrane Attack Complex/Perforin (MACPF) Domain Proteins.
Autorzy :
Keb G; Department of Microbiology, Immunology & Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY, United States.
Fields KA; Department of Microbiology, Immunology & Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Jul 14; Vol. 11, pp. 1490. Date of Electronic Publication: 2020 Jul 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Chlamydia/*physiology
Chlamydia Infections/*immunology
Complement C9/*metabolism
Complement Membrane Attack Complex/*metabolism
Perforin/*metabolism
Animals ; Biological Evolution ; Complement C9/genetics ; Complement Membrane Attack Complex/genetics ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Perforin/genetics
Czasopismo naukowe
Tytuł :
Perforin Acts as an Immune Regulator to Prevent the Progression of NAFLD.
Autorzy :
Wang Q; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, China.; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
Li D; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, China.; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
Zhu J; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, China.; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
Zhang M; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, China.; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
Zhang H; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, China.; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
Cao G; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, China.; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
Zhu L; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, China.; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
Shi Q; The First Affiliated Hospital of Jinan University, Guangzhou, China.
Hao J; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, China.; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
Wen Q; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, China.; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
Liu Z; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, China.; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
Yang H; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, China.; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
Yin Z; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, China.; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 May 22; Vol. 11, pp. 846. Date of Electronic Publication: 2020 May 22 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
CD4-Positive T-Lymphocytes/*immunology
Interferon-gamma/*metabolism
Non-alcoholic Fatty Liver Disease/*immunology
Perforin/*metabolism
Animals ; CD8-Positive T-Lymphocytes/immunology ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Hepatitis/etiology ; Interferon-gamma/genetics ; Lipid Metabolism/genetics ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/blood ; Obesity/metabolism ; Perforin/deficiency ; Perforin/genetics
Czasopismo naukowe
Tytuł :
The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus.
Autorzy :
Vičić M; Department of Dermatovenerology, Clinical Hospital Center Rijeka, Medical Faculty, University of Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.
Sotošek V; Department of Anesthesia, Resuscitation and Intensive Care, Medical Faculty University of Rijeka, Clinical Hospital Center Rijeka, Tome Strižića 3, 51000 Rijeka, Croatia.
Brajac I; Department of Dermatovenerology, Clinical Hospital Center Rijeka, Medical Faculty, University of Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.
Kaštelan M; Department of Dermatovenerology, Clinical Hospital Center Rijeka, Medical Faculty, University of Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.
Prpić-Massari L; Department of Dermatovenerology, Clinical Hospital Center Rijeka, Medical Faculty, University of Rijeka, Krešimirova 42, 51000 Rijeka, Croatia. Electronic address: .
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Źródło :
Medical hypotheses [Med Hypotheses] 2021 Apr; Vol. 149, pp. 110546. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article
MeSH Terms :
Lichen Planus*
CD8-Positive T-Lymphocytes ; Epidermis ; Humans ; Keratinocytes ; Perforin
Czasopismo naukowe
Tytuł :
DNA hypomethylating agents increase activation and cytolytic activity of CD8 T cells.
Autorzy :
Loo Yau H; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
Bell E; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Ettayebi I; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
de Almeida FC; Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, Brazil; Instituto de Investigação em Imunologia, Institutos Nacionais de Ciência e Tecnologia (INCT-iii), São Paulo 05403-900, Brazil.
Boukhaled GM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Shen SY; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Allard D; Centre de recherche du Centre Hospitalier de l'Université de Montréal et Institut du Cancer de Montréal, Montréal, QC H2X 0A9, Canada; Faculté de Pharmacie, Université de Montréal, Montréal, QC H3T 1J4, Canada.
Morancho B; Preclinical Research Program, Vall d'Hebron Institute of Oncology (VHIO) and CIBERONC, 08035 Barcelona, Spain.
Marhon SA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Ishak CA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Gonzaga IM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
da Silva Medina T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Translational Immuno-oncology Laboratory, A.C. Camargo Cancer Center, São Paulo 01509-001, Brazil.
Singhania R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Chakravarthy A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Chen R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
Mehdipour P; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Pommey S; Centre de recherche du Centre Hospitalier de l'Université de Montréal et Institut du Cancer de Montréal, Montréal, QC H2X 0A9, Canada.
Klein C; Roche Pharma Research and Early Development, Roche Innovation Center Zurich, Wagistrasse 10, 8952 Schlieren, Switzerland.
Amarante-Mendes GP; Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, Brazil; Instituto de Investigação em Imunologia, Institutos Nacionais de Ciência e Tecnologia (INCT-iii), São Paulo 05403-900, Brazil.
Roulois D; UMR U1236, INSERM, Université de Rennes 1, EFS, 35000 Rennes, France.
Arribas J; Preclinical Research Program, Vall d'Hebron Institute of Oncology (VHIO) and CIBERONC, 08035 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain; Cancer Research Program, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain.
Stagg J; Centre de recherche du Centre Hospitalier de l'Université de Montréal et Institut du Cancer de Montréal, Montréal, QC H2X 0A9, Canada; Faculté de Pharmacie, Université de Montréal, Montréal, QC H3T 1J4, Canada.
Brooks DG; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
De Carvalho DD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Apr 01; Vol. 81 (7), pp. 1469-1483.e8. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
CpG Islands/*immunology
DNA Methylation/*drug effects
Decitabine/*pharmacology
Granzymes/*immunology
Lymphocyte Activation/*drug effects
DNA Methylation/immunology ; Humans ; NFATC Transcription Factors/immunology ; Perforin/immunology
Czasopismo naukowe
Tytuł :
Adenosine leakage from perforin-burst extracellular vesicles inhibits perforin secretion by cytotoxic T-lymphocytes.
Autorzy :
Tadokoro H; Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan.
Hirayama A; Institute for Advanced Biosciences, Keio University, Yamagata, Japan.
Kudo R; Institute for Advanced Biosciences, Keio University, Yamagata, Japan.
Hasebe M; Institute for Advanced Biosciences, Keio University, Yamagata, Japan.
Yoshioka Y; Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan.; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Matsuzaki J; Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan.
Yamamoto Y; Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan.
Sugimoto M; Institute for Advanced Biosciences, Keio University, Yamagata, Japan.
Soga T; Institute for Advanced Biosciences, Keio University, Yamagata, Japan.
Ochiya T; Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan.; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
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Źródło :
PloS one [PLoS One] 2020 Apr 10; Vol. 15 (4), pp. e0231430. Date of Electronic Publication: 2020 Apr 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine/*metabolism
Extracellular Vesicles/*metabolism
Perforin/*metabolism
T-Lymphocytes, Cytotoxic/*metabolism
Cell Line, Tumor ; Cells, Cultured ; Extracellular Vesicles/drug effects ; Humans ; Interferon-gamma/pharmacology ; Perforin/pharmacology ; T-Lymphocytes, Cytotoxic/drug effects
Czasopismo naukowe
Tytuł :
Inverse relationship between CD40L expression and cytolytic molecule expression by CD8 T follicular cytotoxic cells in colorectal cancer.
Autorzy :
Xing J; Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: .
Li X; Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
E J; Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Wang C; Department of Oncology, Ruijin North Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: .
Wang H; Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 Apr 01; Vol. 389 (1), pp. 111892. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma*/genetics
Adenocarcinoma*/immunology
Adenocarcinoma*/pathology
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/immunology
Colorectal Neoplasms*/pathology
CD40 Ligand/*genetics
Granzymes/*genetics
Perforin/*genetics
T-Lymphocytes, Cytotoxic/*metabolism
Adult ; CD40 Ligand/metabolism ; CD8 Antigens/genetics ; CD8 Antigens/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/pathology ; Case-Control Studies ; Cytotoxicity, Immunologic/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Granzymes/metabolism ; Humans ; Lymphocytes, Tumor-Infiltrating/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Perforin/metabolism ; Receptors, CXCR5/genetics ; Receptors, CXCR5/metabolism ; T-Lymphocytes, Cytotoxic/pathology
Czasopismo naukowe
Tytuł :
Tim-3 suppresses the killing effect of Vγ9Vδ2 T cells on colon cancer cells by reducing perforin and granzyme B expression.
Autorzy :
Li X; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, China.
Lu H; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, China; Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 708 Renmin Road, Suzhou, China; Jiangsu Key Laboratory of Clinical Immunology, Soochow University, 708 Renmin Road, Suzhou, China.
Gu Y; Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 708 Renmin Road, Suzhou, China.
Zhang X; Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 708 Renmin Road, Suzhou, China; Jiangsu Key Laboratory of Clinical Immunology, Soochow University, 708 Renmin Road, Suzhou, China.
Zhang G; Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology, The First Affiliated Hospital of Soochow University, 708 Renmin Road, Suzhou, China.
Shi T; Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 708 Renmin Road, Suzhou, China; Jiangsu Key Laboratory of Clinical Immunology, Soochow University, 708 Renmin Road, Suzhou, China. Electronic address: .
Chen W; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 Jan 01; Vol. 386 (1), pp. 111719. Date of Electronic Publication: 2019 Nov 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colonic Neoplasms/*immunology
Granzymes/*metabolism
Hepatitis A Virus Cellular Receptor 2/*metabolism
Intraepithelial Lymphocytes/*immunology
Perforin/*metabolism
Aged ; Cells, Cultured ; Colonic Neoplasms/therapy ; Female ; Granzymes/genetics ; HCT116 Cells ; Hepatitis A Virus Cellular Receptor 2/genetics ; Humans ; Immunotherapy/methods ; MAP Kinase Signaling System ; Male ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Perforin/genetics
Czasopismo naukowe
Tytuł :
Co-Occurrence of Familial Hemophagocytic Lymphohistiocytosis Type 2 and Chronic Active Epstein-Barr Virus in Adulthood.
Autorzy :
Godby RC; Department of Medicine, Division of General Internal Medicine, University of Alabama at Birmingham, Birmingham, AL, United States; Department of Pathology, Division of Laboratory Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. Electronic address: .
Kraemer RR; Department of Medicine, Division of General Internal Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
May J; Department of Medicine, Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, United States.
Soni S; Teerthanker Mahaveer Medical College & Research Centre, Moradabad, UP, India.
Reddy V; Department of Pathology, Division of Laboratory Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Thomas JV; Department of Radiology, Division of Diagnostic Radiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Mehta A; Department of Medicine, Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, United States.
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Źródło :
The American journal of the medical sciences [Am J Med Sci] 2021 Mar; Vol. 361 (3), pp. 388-393. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Epstein-Barr Virus Infections/*diagnosis
Lymphohistiocytosis, Hemophagocytic/*diagnosis
Adult ; Chronic Disease ; Diagnosis, Differential ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/virology ; Herpesvirus 4, Human/isolation & purification ; Humans ; India/ethnology ; Lymphohistiocytosis, Hemophagocytic/complications ; Lymphohistiocytosis, Hemophagocytic/genetics ; Male ; Perforin/analysis
SCR Disease Name :
Hemophagocytic lymphohistiocytosis, familial, 2
Czasopismo naukowe
Tytuł :
Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo.
Autorzy :
Spicer JA; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, A New Zealand Centre for Research Excellence, Auckland 1010, New Zealand.
Miller CK; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, A New Zealand Centre for Research Excellence, Auckland 1010, New Zealand.
O'Connor PD; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, A New Zealand Centre for Research Excellence, Auckland 1010, New Zealand.
Jose J; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, A New Zealand Centre for Research Excellence, Auckland 1010, New Zealand.
Giddens AC; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Jaiswal JK; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, A New Zealand Centre for Research Excellence, Auckland 1010, New Zealand.
Jamieson SMF; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, A New Zealand Centre for Research Excellence, Auckland 1010, New Zealand.; Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Bull MR; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, A New Zealand Centre for Research Excellence, Auckland 1010, New Zealand.
Denny WA; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, A New Zealand Centre for Research Excellence, Auckland 1010, New Zealand.
Akhlaghi H; Cancer Immunology Program, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia.
Trapani JA; Cancer Immunology Program, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052, Australia.
Hill GR; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland 4006, Australia.
Chang K; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland 4006, Australia.
Gartlan KH; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland 4006, Australia.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Mar 12; Vol. 63 (5), pp. 2229-2239. Date of Electronic Publication: 2019 Sep 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Marrow Transplantation*
Stem Cell Transplantation*
Graft Rejection/*prevention & control
Perforin/*antagonists & inhibitors
Sulfonamides/*therapeutic use
Animals ; Cell Line ; Graft Rejection/immunology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Perforin/immunology ; Sulfonamides/chemistry ; Sulfonamides/pharmacokinetics
Czasopismo naukowe
Tytuł :
A novel homozygous disruptive PRF1 variant (K285Sfs*4) causes very early-onset of familial hemophagocytic lymphohystiocytosis type 2.
Autorzy :
Saettini F; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
Castelli I; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
Provenzi M; Pediatric Unit, Hospital Papa Giovanni XXIII, Bergamo, Italy.
Fazio G; Centro Ricerca Tettamanti, University of Milan Bicocca, Monza, Italy.
Quadri M; Centro Ricerca Tettamanti, University of Milan Bicocca, Monza, Italy.
Cazzaniga G; Centro Ricerca Tettamanti, University of Milan Bicocca, Monza, Italy.; Department of Medicine and Surgery, University of Milan Bicocca, Monza, Italy.
Sala S; Centro Ricerca Tettamanti, University of Milan Bicocca, Monza, Italy.
Dell'Acqua F; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
Sieni E; Department of Paediatric Oncohematology, Meyer Children's University Hospital, Florence, Italy.
Coniglio ML; Department of Paediatric Oncohematology, Meyer Children's University Hospital, Florence, Italy.
Pezzoli L; Molecular Genetics Laboratory, USSD LGM, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Iascone M; Molecular Genetics Laboratory, USSD LGM, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Vendemini F; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
Balduzzi AC; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
Biondi A; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.; Centro Ricerca Tettamanti, University of Milan Bicocca, Monza, Italy.
Rizzari C; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
Bonanomi S; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
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Źródło :
Pediatric hematology and oncology [Pediatr Hematol Oncol] 2021 Mar; Vol. 38 (2), pp. 174-178. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Lymphohistiocytosis, Hemophagocytic/*genetics
Perforin/*metabolism
Disease Progression ; Humans ; Infant ; Lymphohistiocytosis, Hemophagocytic/pathology ; Male
Raport
Tytuł :
[Synergistic Mechanism of Interferon alpha-1b, Interleukin-2 and Thalidomide for Immune Regulation in Patients with Acute Myeloid Leukemia].
Autorzy :
Mi RH; Cancer Hospital Affiliated to Zhengzhou University/Henan Cancer Hospital, Zhengzhou 450008, Henan Province, China.
Chen L; Cancer Hospital Affiliated to Zhengzhou University/Henan Cancer Hospital, Zhengzhou 450008, Henan Province, China.
Zhou YL; Cancer Hospital Affiliated to Zhengzhou University/Henan Cancer Hospital, Zhengzhou 450008, Henan Province, China.
Li DB; Cancer Hospital Affiliated to Zhengzhou University/Henan Cancer Hospital, Zhengzhou 450008, Henan Province, China.
Liu S; Cancer Hospital Affiliated to Zhengzhou University/Henan Cancer Hospital, Zhengzhou 450008, Henan Province, China.
Wang XJ; Cancer Hospital Affiliated to Zhengzhou University/Henan Cancer Hospital, Zhengzhou 450008, Henan Province, China.
Liu J; Cancer Hospital Affiliated to Zhengzhou University/Henan Cancer Hospital, Zhengzhou 450008, Henan Province, China.
Wang MF; Pingdingshan First People's Hospital, Pingdingshan 467000, Henan Province, China.
Ma XM; Pingdingshan First People's Hospital, Pingdingshan 467000, Henan Province, China.
Li ZC; Puyang City People's Hospital, Puyang 457000, Henan Province, China.
Zhao HM; Huaihe Hospital of Henan University, Kaifeng 475000, Henan Province, China.
Xu YL; 989th,Hospital of PLA, Luoyang 471000, Henan Province, China.
Chen SX; Shangqiu city First People's Hospital, Shangqiu 476000, Henan Province, China.
Yang HP; First Affiliated Hospital of Science and Technology University of Henan, Luoyang 471000, Henan Province, China.
Guo ZQ; Central Hospital of Zhengzhou, Zhengzhou 450000, Henan Province, China.
Luan CL; Anyang District Hospital, Anyang 455000, Henan Province, China.
Guo SL; Central Hospital of Luoyang, Luoyang 471000, Henan Province, China.
Song QL; Jiaozuo People's Hospital, Jiaozuo 454150, Henan Province, China.
Wei XD; Cancer Hospital Affiliated to Zhengzhou University/Henan Cancer Hospital, Zhengzhou 450008, Henan Province, China. E-mail:.
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2021 Feb; Vol. 29 (1), pp. 26-31.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-2*
Leukemia, Myeloid, Acute*/drug therapy
CD8-Positive T-Lymphocytes ; Humans ; Interferon-alpha ; Perforin ; Thalidomide
Czasopismo naukowe
Tytuł :
Granzyme B Induces IRF-3 Phosphorylation through a Perforin-Independent Proteolysis-Dependent Signaling Cascade without Inducing Cell Death.
Autorzy :
Gapud EJ; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Trejo-Zambrano MI; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Gomez-Banuelos E; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Tiniakou E; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Antiochos B; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Granville DJ; International Collaboration on Repair Discoveries Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.
Andrade F; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Casciola-Rosen L; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Rosen A; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224; .; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21224; and.; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Jan 15; Vol. 206 (2), pp. 335-344. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Fibroblasts/*physiology
Granzymes/*metabolism
Interferon Regulatory Factor-3/*metabolism
Apoptosis ; Cell Survival ; Cells, Cultured ; Granzymes/genetics ; HEK293 Cells ; Humans ; Interferon Regulatory Factor-3/genetics ; Mutation/genetics ; Perforin/metabolism ; Phosphorylation ; Proteolysis ; Signal Transduction
Czasopismo naukowe
Tytuł :
Cell Softness Prevents Cytolytic T-cell Killing of Tumor-Repopulating Cells.
Autorzy :
Liu Y; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China. .; Clinical Immunology Center, CAMS, Beijing, China.
Zhang T; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.
Zhang H; National Cancer Center/Cancer Hospital, CAMS, Beijing, China.
Li J; Beijing Smartchip Microelectronics Technology Company Limited, Beijing, China.
Zhou N; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.
Fiskesund R; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.; Karolinska Institutet Medical School, Stockholm, Sweden.
Chen J; Laboratory for Cellular Biomechanics and Regenerative Medicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Lv J; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.
Ma J; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhang H; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tang K; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Cheng F; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.
Zhou Y; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.
Zhang X; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Wang N; Department of Mechanical Science and Engineering, College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Huang B; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China. .; Clinical Immunology Center, CAMS, Beijing, China.; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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Źródło :
Cancer research [Cancer Res] 2021 Jan 15; Vol. 81 (2), pp. 476-488. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colonic Neoplasms/*pathology
Cytotoxicity, Immunologic/*immunology
Melanoma/*pathology
Perforin/*metabolism
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Apoptosis ; Cell Proliferation ; Colonic Neoplasms/immunology ; Colonic Neoplasms/metabolism ; Female ; Humans ; Melanoma/immunology ; Melanoma/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, SCID ; Myosin Heavy Chains/genetics ; Myosin Heavy Chains/metabolism ; Pore Forming Cytotoxic Proteins/genetics ; Pore Forming Cytotoxic Proteins/metabolism ; Prognosis ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Rare Genetic Variants in Immune Genes and Neonatal Herpes Simplex Viral Infections.
Autorzy :
Cummings L; Divisions of Neonatology and.
Tucker M; Divisions of Neonatology and .
Gibson M; Center for Pediatric Genomic Medicine, Children's Mercy Hospital, Kansas City, Missouri.
Myers A; Infectious Disease and.
Pastinen T; Center for Pediatric Genomic Medicine, Children's Mercy Hospital, Kansas City, Missouri.
Johnston J; Center for Pediatric Genomic Medicine, Children's Mercy Hospital, Kansas City, Missouri.
Farrow E; Center for Pediatric Genomic Medicine, Children's Mercy Hospital, Kansas City, Missouri.
Sampath V; Divisions of Neonatology and.
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Źródło :
Pediatrics [Pediatrics] 2021 Jan; Vol. 147 (1). Date of Electronic Publication: 2020 Dec 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Variation*
Herpes Simplex/*genetics
Pregnancy Complications, Infectious/*genetics
Complement C6/genetics ; Complement C7/genetics ; DNA-Binding Proteins/genetics ; Female ; GRB2 Adaptor Protein/genetics ; Humans ; Infant, Newborn ; Interferon Regulatory Factor-3/genetics ; Male ; Nuclear Proteins/genetics ; Perforin/genetics ; Pilot Projects ; Pregnancy ; RNA Nucleotidyltransferases/genetics ; STAT1 Transcription Factor/genetics ; Scavenger Receptors, Class A/genetics ; TNF Receptor-Associated Factor 3/genetics ; Toll-Like Receptor 3/genetics ; Whole Exome Sequencing
SCR Disease Name :
Neonatal herpes
Czasopismo naukowe
Tytuł :
Functional studies of aegerolysin and MACPF-like proteins in Aspergillus niger.
Autorzy :
Novak M; Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Čepin U; BioSistemika Ltd and National Institute of Biology, Ljubljana, Slovenia.
Hodnik V; Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Narat M; Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Jamnik M; Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Ljubljana, Slovenia.
Kraševec N; Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Ljubljana, Slovenia.
Sepčić K; Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Anderluh G; Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Ljubljana, Slovenia.
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Źródło :
Molecular microbiology [Mol Microbiol] 2019 Oct; Vol. 112 (4), pp. 1253-1269. Date of Electronic Publication: 2019 Aug 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Complement Membrane Attack Complex/*metabolism
Fungal Proteins/*metabolism
Hemolysin Proteins/*metabolism
Perforin/*metabolism
Aspergillus niger/genetics ; Aspergillus niger/metabolism ; Complement Membrane Attack Complex/genetics ; Fungal Proteins/physiology ; Gene Expression Regulation, Fungal/genetics ; Hemolysin Proteins/physiology ; Membrane Proteins/metabolism ; Perforin/genetics ; Sphingolipids/metabolism ; Spores, Fungal/genetics ; Spores, Fungal/metabolism
Czasopismo naukowe

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