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Wyświetlanie 61-80 z 3249
Tytuł:
Lipid-Binding Aegerolysin from Biocontrol Fungus Beauveria bassiana .
Autorzy:
Kraševec N; Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.
Panevska A; Department of Biology, Biotechnical Faculty, University of Ljubljana, SI-1000 Ljubljana, Slovenia.
Lemež Š; Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.; Biotechnology, Biotechnical Faculty, University of Ljubljana, SI-1000 Ljubljana, Slovenia.
Razinger J; Plant Protection Department, Agricultural Institute of Slovenia, Hacquetova 17, SI-1000 Ljubljana, Slovenia.
Sepčić K; Department of Biology, Biotechnical Faculty, University of Ljubljana, SI-1000 Ljubljana, Slovenia.
Anderluh G; Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.
Podobnik M; Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.
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Źródło:
Toxins [Toxins (Basel)] 2021 Nov 20; Vol. 13 (11). Date of Electronic Publication: 2021 Nov 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pest Control, Biological*
Beauveria/*pathogenicity
Fungal Proteins/*metabolism
Hemolysin Proteins/*metabolism
Animals ; Beauveria/genetics ; Complement Membrane Attack Complex/metabolism ; Computational Biology ; Genome, Fungal ; Insecta/metabolism ; Membrane Lipids/metabolism ; Perforin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Killing capacity analysis of tumor-infiltrating cytotoxic lymphocytes and impact on lymph node metastasis in differentiated papillary carcinoma of thyroid with the BRAF V600E mutation
Autorzy:
Xiaogang Liu
Honggang Liu
Lu Wang
Yubing Han
Linghong Kong
Xinpeng Zhang
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Temat:
Papillary carcinoma of the thyroid
Cytotoxic lymphocytes
Perforin
Granzyme B
Lymph node metastasis
Pathology
RB1-214
Źródło:
Diagnostic Pathology, Vol 19, Iss 1, Pp 1-9 (2024)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/1746-1596
Dostęp URL:
https://doaj.org/article/9ec1fb4a843b4b9cae173793a3461916  Link otwiera się w nowym oknie
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Extracellular CIRP induces CD4CD8αα intraepithelial lymphocyte cytotoxicity in sepsis
Autorzy:
Yuichi Akama
Atsushi Murao
Monowar Aziz
Ping Wang
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Temat:
CD4CD8αα IEL
Intestine
Sepsis
eCIRP
Granzyme B
Perforin
Therapeutics. Pharmacology
RM1-950
Biochemistry
QD415-436
Źródło:
Molecular Medicine, Vol 30, Iss 1, Pp 1-14 (2024)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/1528-3658
Dostęp URL:
https://doaj.org/article/55347991260f464da362d1509a321382  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
Summary and comparison of the perforin in teleosts and mammals: A review.
Autorzy:
Xu J; School of Agriculture, Ludong University, Yantai, China.
Yang N; School of Agriculture, Ludong University, Yantai, China.
Xie T; School of Agriculture, Ludong University, Yantai, China.
Yang G; Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China.
Chang L; School of Agriculture, Ludong University, Yantai, China.
Yan D; School of Agriculture, Ludong University, Yantai, China.
Li T; School of Agriculture, Ludong University, Yantai, China.
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Źródło:
Scandinavian journal of immunology [Scand J Immunol] 2021 Jul; Vol. 94 (1), pp. e13047. Date of Electronic Publication: 2021 May 09.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Fishes/*metabolism
Mammals/*metabolism
Perforin/*metabolism
Animals ; Cell Membrane/metabolism ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identification of CD56 interferon-α-induced dendritic cells.
Autorzy:
Watanabe A; Department of Regenerative Medicine, School of Medicine, Kanazawa Medical University, Kahoku-gun, Japan.
Togi M; Department of Regenerative Medicine, School of Medicine, Kanazawa Medical University, Kahoku-gun, Japan.; Division of Stem Cell Medicine, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Kahoku-gun, Japan.
Koya T; Department of Regenerative Medicine, School of Medicine, Kanazawa Medical University, Kahoku-gun, Japan.
Taniguchi M; Division of Genome Damage Response Research, Department of Life Science, Medical Research Institute, Kanazawa Medical University, Kahoku-gun, Japan.
Sakamoto T; Department of Regenerative Medicine, School of Medicine, Kanazawa Medical University, Kahoku-gun, Japan.
Iwabuchi K; Division of Genome Damage Response Research, Department of Life Science, Medical Research Institute, Kanazawa Medical University, Kahoku-gun, Japan.; Department of Biochemistry I, School of Medicine, Kanazawa Medical University, Kahoku-gun, Japan.
Kato T Jr; Division of Stem Cell Medicine, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Kahoku-gun, Japan.
Shimodaira S; Department of Regenerative Medicine, School of Medicine, Kanazawa Medical University, Kahoku-gun, Japan.; Division of Stem Cell Medicine, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Kahoku-gun, Japan.
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Źródło:
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2021 May; Vol. 26 (5), pp. 313-327. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji:
Journal Article
MeSH Terms:
CD56 Antigen/*metabolism
Dendritic Cells/*metabolism
Granzymes/*metabolism
Interferon-alpha/*pharmacology
Perforin/*metabolism
Serpins/*metabolism
Biomarkers/metabolism ; Cell Death/drug effects ; Cells, Cultured ; Dendritic Cells/drug effects ; Humans ; Lipopolysaccharide Receptors/metabolism ; Macrolides/pharmacology ; Monocytes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Novel immunoregulatory role of perforin-positive dendritic cells.
Autorzy:
Orgad R; Department of Immunology, Weizmann Institute of Science, Herzel St. 1, 76100, Rehovot, Israel.
Nathansohn-Levi B; Department of Immunology, Weizmann Institute of Science, Herzel St. 1, 76100, Rehovot, Israel.
Kagan S; Department of Immunology, Weizmann Institute of Science, Herzel St. 1, 76100, Rehovot, Israel.
Zlotnikov Klionsky Y; Department of Immunology, Weizmann Institute of Science, Herzel St. 1, 76100, Rehovot, Israel.
Reisner Y; Department of Immunology, Weizmann Institute of Science, Herzel St. 1, 76100, Rehovot, Israel. .
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Źródło:
Seminars in immunopathology [Semin Immunopathol] 2017 Feb; Vol. 39 (2), pp. 121-133. Date of Electronic Publication: 2016 Aug 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Immunomodulation*
Dendritic Cells/*immunology
Dendritic Cells/*metabolism
Perforin/*metabolism
Animals ; Autoimmunity ; Cell Differentiation ; Cytotoxicity, Immunologic ; Dendritic Cells/classification ; Dendritic Cells/cytology ; Disease Models, Animal ; Disease Susceptibility ; Encephalomyelitis, Autoimmune, Experimental ; Histocompatibility Antigens/immunology ; Histocompatibility Antigens/metabolism ; Humans ; Immune Tolerance ; Metabolic Syndrome/etiology ; Metabolic Syndrome/metabolism ; Perforin/genetics ; Signal Transduction ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Bladder tumor ILC1s undergo Th17-like differentiation in human bladder cancer.
Autorzy:
Mukherjee N; Department of Urology, University of Texas Health San Antonio (UTHSA), San Antonio, Texas, USA.
Ji N; Department of Urology, University of Texas Health San Antonio (UTHSA), San Antonio, Texas, USA.
Tan X; Department of Molecular Medicine, University of Texas Health San Antonio (UTHSA), San Antonio, Texas, USA.
Lin CL; Department of Molecular Medicine, University of Texas Health San Antonio (UTHSA), San Antonio, Texas, USA.
Rios E; Department of Urology, University of Texas Health San Antonio (UTHSA), San Antonio, Texas, USA.
Chen CL; Department of Molecular Medicine, University of Texas Health San Antonio (UTHSA), San Antonio, Texas, USA.
Huang T; Department of Molecular Medicine, University of Texas Health San Antonio (UTHSA), San Antonio, Texas, USA.
Svatek RS; Department of Urology, University of Texas Health San Antonio (UTHSA), San Antonio, Texas, USA.
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Źródło:
Cancer medicine [Cancer Med] 2021 Oct; Vol. 10 (20), pp. 7101-7110. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji:
Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Differentiation*
Lymphocytes, Tumor-Infiltrating/*cytology
Th17 Cells/*cytology
Urinary Bladder Neoplasms/*pathology
Aged ; Antigens, CD/metabolism ; Antigens, Differentiation, T-Lymphocyte/metabolism ; Female ; Flow Cytometry ; Hepatitis A Virus Cellular Receptor 2/metabolism ; Humans ; Image Cytometry ; Immunity, Cellular ; Interferon-gamma/metabolism ; Interleukin-17/metabolism ; Interleukins/metabolism ; Lectins, C-Type/metabolism ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Male ; Natural Cytotoxicity Triggering Receptor 1/metabolism ; Natural Cytotoxicity Triggering Receptor 3/metabolism ; Neoplasm Invasiveness ; Perforin/metabolism ; Programmed Cell Death 1 Receptor/metabolism ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Urinary Bladder Neoplasms/immunology ; Interleukin-22
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Differential Response of MDA-MB-231 and MCF-7 Breast Cancer Cells to In Vitro Inhibition with CTLA-4 and PD-1 through Cancer-Immune Cells Modified Interactions.
Autorzy:
Grubczak K; Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Jerzego Waszyngtona 13, 15-269 Bialystok, Poland.
Kretowska-Grunwald A; Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Jerzego Waszyngtona 13, 15-269 Bialystok, Poland.
Groth D; Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Jerzego Waszyngtona 13, 15-269 Bialystok, Poland.
Poplawska I; Department of Medical Pathomorphology, Medical University of Bialystok, Jerzego Waszyngtona 13, 15-269 Bialystok, Poland.
Eljaszewicz A; Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Jerzego Waszyngtona 13, 15-269 Bialystok, Poland.
Bolkun L; Department of Haematology, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland.
Starosz A; Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Jerzego Waszyngtona 13, 15-269 Bialystok, Poland.
Holl JM; Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Jerzego Waszyngtona 13, 15-269 Bialystok, Poland.
Mysliwiec M; Department of Oncology, Medical University of Bialystok, Ogrodowa 12, 15-027 Bialystok, Poland.
Kruszewska J; Department of Oncology, Medical University of Bialystok, Ogrodowa 12, 15-027 Bialystok, Poland.
Wojtukiewicz MZ; Department of Oncology, Medical University of Bialystok, Ogrodowa 12, 15-027 Bialystok, Poland.
Moniuszko M; Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Jerzego Waszyngtona 13, 15-269 Bialystok, Poland.; Department of Allergology and Internal Medicine, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland.
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Źródło:
Cells [Cells] 2021 Aug 10; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CTLA-4 Antigen/*immunology
Leukocytes, Mononuclear/*metabolism
Programmed Cell Death 1 Receptor/*immunology
Adult ; Antibodies/immunology ; B7-1 Antigen/metabolism ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; CTLA-4 Antigen/metabolism ; Cell Cycle Checkpoints ; Cell Line, Tumor ; Cell Proliferation ; Coculture Techniques ; Female ; Granzymes/metabolism ; Humans ; Interferon-gamma/metabolism ; Interleukin-10/metabolism ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/immunology ; MCF-7 Cells ; Perforin/metabolism ; Programmed Cell Death 1 Receptor/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Degranulation enhances presynaptic membrane packing, which protects NK cells from perforin-mediated autolysis.
Autorzy:
Li Y; Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America.; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, United States of America.
Orange JS; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2021 Aug 03; Vol. 19 (8), pp. e3001328. Date of Electronic Publication: 2021 Aug 03 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cell Degranulation*
Killer Cells, Natural/*physiology
Membrane Lipids/*metabolism
Perforin/*metabolism
Cell Line, Tumor ; Cell Survival ; Healthy Volunteers ; Humans ; Ketocholesterols ; Primary Cell Culture
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Expression of perforin, granzyme A and Fas ligand mRNA in caecal tissues upon Eimeria tenella infection of naïve and immune chickens.
Autorzy:
Wattrang E; Department of Microbiology, National Veterinary Institute, Uppsala, Sweden.
Magnusson SE; Department of Microbiology, National Veterinary Institute, Uppsala, Sweden.
Näslund K; Department of Microbiology, National Veterinary Institute, Uppsala, Sweden.
Thebo P; Department of Microbiology, National Veterinary Institute, Uppsala, Sweden.
Hagström Å; Department of Microbiology, National Veterinary Institute, Uppsala, Sweden.
Smith AL; Department of Zoology, University of Oxford, Oxford, UK.
Lundén A; Department of Microbiology, National Veterinary Institute, Uppsala, Sweden.
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Źródło:
Parasite immunology [Parasite Immunol] 2016 Jul; Vol. 38 (7), pp. 419-30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cecum/*parasitology
Coccidiosis/*veterinary
Eimeria tenella/*physiology
Fas Ligand Protein/*genetics
Granzymes/*genetics
Perforin/*genetics
Poultry Diseases/*genetics
Poultry Diseases/*parasitology
Animals ; Cecum/immunology ; Chickens/genetics ; Chickens/immunology ; Chickens/parasitology ; Coccidiosis/genetics ; Coccidiosis/immunology ; Coccidiosis/parasitology ; Eimeria tenella/genetics ; Eimeria tenella/growth & development ; Fas Ligand Protein/immunology ; Granzymes/immunology ; Perforin/immunology ; Poultry Diseases/immunology ; RNA, Messenger/genetics ; RNA, Messenger/immunology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/parasitology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Increased Uterine NK cell numbers and perforin expression during the implantation phase in IVF Cycles with GnRH Antagonist Protocol.
Autorzy:
Xu B; Reproductive Medical Center of Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Wang J; Reproductive Medical Center of Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Xia L; Reproductive Medical Center of Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Zhang D; Reproductive Medical Center of Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Wu X; Reproductive Medical Center of Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Zhang A; Reproductive Medical Center of Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.; Shanghai Key Laboratory of Reproductive Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
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Źródło:
Scientific reports [Sci Rep] 2017 Jan 03; Vol. 7, pp. 39912. Date of Electronic Publication: 2017 Jan 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Embryo, Mammalian/*drug effects
Follicle Stimulating Hormone/*pharmacology
Gonadotropin-Releasing Hormone/*antagonists & inhibitors
Killer Cells, Natural/*cytology
Perforin/*metabolism
Adult ; CD56 Antigen/genetics ; CD56 Antigen/metabolism ; Embryo Implantation ; Embryo, Mammalian/metabolism ; Fas Ligand Protein/genetics ; Fas Ligand Protein/metabolism ; Female ; Fertilization in Vitro ; Follicle Stimulating Hormone/genetics ; Follicle Stimulating Hormone/metabolism ; Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/pathology ; Oligonucleotide Array Sequence Analysis ; Perforin/genetics ; Principal Component Analysis ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/pharmacology ; Triptorelin Pamoate/pharmacology ; Uterus/cytology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Influence of Galectin-9 Treatment on the Phenotype and Function of NK-92MI Cells in the Presence of Different Serum Supplements.
Autorzy:
Meggyes M; Department of Medical Microbiology and Immunology, Medical School, University of Pecs, 12 Szigeti Street, 7624 Pecs, Hungary.; Janos Szentagothai Research Centre, University of Pecs, 20 Ifjusag Street, 7624 Pecs, Hungary.
Nagy DU; Medical Centre, Cochrane Hungary, University of Pecs, 7623 Pecs, Hungary.
Balassa T; Department of Medical Microbiology and Immunology, Medical School, University of Pecs, 12 Szigeti Street, 7624 Pecs, Hungary.
Godony K; Department of Obstetrics and Gynaecology, Medical School, University of Pecs, 17 Edesanyak Street, 7624 Pecs, Hungary.
Peterfalvi A; Department of Laboratory Medicine, Medical School, University of Pecs, 13 Ifjusag Street, 7624 Pecs, Hungary.
Szereday L; Department of Medical Microbiology and Immunology, Medical School, University of Pecs, 12 Szigeti Street, 7624 Pecs, Hungary.; Janos Szentagothai Research Centre, University of Pecs, 20 Ifjusag Street, 7624 Pecs, Hungary.
Polgar B; Department of Medical Microbiology and Immunology, Medical School, University of Pecs, 12 Szigeti Street, 7624 Pecs, Hungary.; Janos Szentagothai Research Centre, University of Pecs, 20 Ifjusag Street, 7624 Pecs, Hungary.
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Źródło:
Biomolecules [Biomolecules] 2021 Jul 22; Vol. 11 (8). Date of Electronic Publication: 2021 Jul 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Galectins/*metabolism
Lymphoma, Non-Hodgkin/*pathology
Serum/*chemistry
Adaptive Immunity ; Animals ; Antigens, CD/metabolism ; Antigens, Differentiation, T-Lymphocyte/metabolism ; Cell Line, Tumor ; Cytokines/metabolism ; Fas Ligand Protein/metabolism ; Gene Expression ; Hepatitis A Virus Cellular Receptor 2/metabolism ; Humans ; Immunity, Innate ; Immunotherapy/methods ; K562 Cells ; Killer Cells, Natural/metabolism ; Lectins, C-Type/metabolism ; Lymphoma, Non-Hodgkin/metabolism ; Mice ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; Neoplasms/immunology ; Neoplasms/pathology ; Perforin/metabolism ; Phenotype ; Recombinant Proteins/chemistry ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In vitro Interleukin-7 treatment partially rescues MAIT cell dysfunction caused by SARS-CoV-2 infection.
Autorzy:
Hubrack S; Department of Human Genetics, Research Branch, Sidra Medicine, 26999, Doha, Qatar. .
Al-Nesf MA; Allergy and Clinical Immunology Section, Hamad Medical Corporation, 3050, Doha, Qatar.; Center of Metabolism and Inflammation, Division of Medicine, Royal Free Campus, University College London, Rowland Hill Road, London, NW3 2PF, UK.
Agrebi N; Department of Human Genetics, Research Branch, Sidra Medicine, 26999, Doha, Qatar.
Raynaud C; Department of Human Genetics, Research Branch, Sidra Medicine, 26999, Doha, Qatar.
Khattab MA; Division of Infectious Disease, Hamad Medical Corporation, 3050, Doha, Qatar.
Thomas M; Pulmonary Division, Hamad Medical Corporation, 3050, Doha, Qatar.
Ibrahim T; Allergy and Clinical Immunology Section, Hamad Medical Corporation, 3050, Doha, Qatar.
Taha S; Allergy and Clinical Immunology Section, Hamad Medical Corporation, 3050, Doha, Qatar.
Dermime S; Translational Cancer Research Facility, National Center for Cancer Care and Research, Translational Research Institute, Hamad Medical Corporation, 3050, Doha, Qatar.
Merhi M; Translational Cancer Research Facility, National Center for Cancer Care and Research, Translational Research Institute, Hamad Medical Corporation, 3050, Doha, Qatar.
Kulinski M; Translational Research Institute, Hamad Medical Corporation, 3050, Doha, Qatar.
Steinhoff M; Translational Research Institute, Hamad Medical Corporation, 3050, Doha, Qatar.; Weill Cornell Medicine, 24144, Doha, Qatar.; Weill Cornell Medicine, New York, NY, 10021, USA.; Department of Dermatology, Hamad Medical Corporation, 3050, Doha, Qatar.
Tang P; Department of Pathology, Sidra Medicine, 26999, Doha, Qatar.
Lo B; Department of Human Genetics, Research Branch, Sidra Medicine, 26999, Doha, Qatar. .; College of Health and Life Sciences, Hamad Bin Khalifa University, 34110, Doha, Qatar. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jul 08; Vol. 11 (1), pp. 14090. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19/*prevention & control
COVID-19/*virology
Interleukin-7/*pharmacology
Mucosal-Associated Invariant T Cells/*physiology
Mucosal-Associated Invariant T Cells/*virology
SARS-CoV-2/*pathogenicity
Cells, Cultured ; Female ; Granzymes/metabolism ; Humans ; Male ; Mucosal-Associated Invariant T Cells/metabolism ; Perforin/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Bone marrow-derived mesenchymal stem cells inhibit CD8 T cell immune responses via PD-1/PD-L1 pathway in multiple myeloma.
Autorzy:
Liu Z; Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Mi F; Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Han M; Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Tian M; Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Deng L; Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Meng N; Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Luo J; Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Fu R; Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2021 Jul; Vol. 205 (1), pp. 53-62. Date of Electronic Publication: 2021 May 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
B7-H1 Antigen/*immunology
Bone Marrow/*immunology
CD8-Positive T-Lymphocytes/*immunology
Immunity/*immunology
Mesenchymal Stem Cells/*immunology
Multiple Myeloma/*immunology
Programmed Cell Death 1 Receptor/*immunology
Adult ; Aged ; Aged, 80 and over ; CD4-Positive T-Lymphocytes/immunology ; Female ; Granzymes/immunology ; Humans ; Killer Cells, Natural/immunology ; Male ; Middle Aged ; Perforin/immunology ; Signal Transduction/immunology ; Thalidomide/analogs & derivatives ; Thalidomide/immunology ; Tumor Escape/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identification of Novel Genomic-Variant Patterns of OR56A5, OR52L1, and CTSD in Retinitis Pigmentosa Patients by Whole-Exome Sequencing.
Autorzy:
Lin TY; College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Chang YC; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.
Hsiao YJ; College of Medicine, National Yang-Ming Chiao-Tung University, Taipei 11217, Taiwan.
Chien Y; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; Institute of Pharmacology, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.
Jheng YC; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.; Big Data Center, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
Wu JR; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Ching LJ; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Hwang DK; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.; Institute of Clinical Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.
Hsu CC; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.
Lin TC; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.; Institute of Clinical Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.
Chou YB; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.
Huang YM; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.
Chen SJ; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.; School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.
Yang YP; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.; Department of Internal Medicine, Taipei Veterans General Hospital, Taipei 112201, Taiwan.; Critical Center, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
Tsai PH; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; Institute of Pharmacology, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 May 25; Vol. 22 (11). Date of Electronic Publication: 2021 May 25.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Genetic Predisposition to Disease*
Cathepsin D/*genetics
Retinal Dystrophies/*genetics
Adult ; Aged ; Cathepsin D/blood ; Female ; Frameshift Mutation ; Gene Ontology ; Humans ; Male ; Middle Aged ; Muscle Proteins/genetics ; Mutation, Missense ; Pedigree ; Perforin/genetics ; Plasma Membrane Calcium-Transporting ATPases/genetics ; Polymorphism, Single Nucleotide ; Protein Interaction Maps ; Retinal Dystrophies/congenital ; Retinal Dystrophies/pathology ; Retinitis Pigmentosa/congenital ; Retinitis Pigmentosa/diagnostic imaging ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/pathology ; Risk Factors ; Tomography, Optical Coherence ; Exome Sequencing
Czasopismo naukowe
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Tytuł:
Pathogenic Pore Forming Proteins of Plasmodium Triggers the Necrosis of Endothelial Cells Attributed to Malaria Severity.
Autorzy:
Shivappagowdar A; Department of Life Science, School of Natural Sciences, Shiv Nadar University, Chithera, Gautam Buddha Nagar, Uttar Pradesh 201314, India.
Garg S; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Srivastava A; Department of Life Science, School of Natural Sciences, Shiv Nadar University, Chithera, Gautam Buddha Nagar, Uttar Pradesh 201314, India.
Hada RS; Department of Life Science, School of Natural Sciences, Shiv Nadar University, Chithera, Gautam Buddha Nagar, Uttar Pradesh 201314, India.
Kalia I; Infectious Disease Lab, National Institute of Immunology, New Delhi 110067, India.
Singh AP; Infectious Disease Lab, National Institute of Immunology, New Delhi 110067, India.
Garg LC; Gene Regulation Laboratory, National Institute of Immunology, New Delhi 110067, India.
Pati S; Department of Life Science, School of Natural Sciences, Shiv Nadar University, Chithera, Gautam Buddha Nagar, Uttar Pradesh 201314, India.
Singh S; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
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Źródło:
Toxins [Toxins (Basel)] 2021 Jan 15; Vol. 13 (1). Date of Electronic Publication: 2021 Jan 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endothelial Cells/*parasitology
Malaria, Falciparum/*parasitology
Necrosis/*parasitology
Perforin/*adverse effects
Protozoan Proteins/*adverse effects
Animals ; Apoptosis ; Biomarkers/metabolism ; Blood-Brain Barrier ; Calcium/metabolism ; Cell Line ; Cell Membrane Permeability ; Cell Survival ; Dogs ; Erythrocytes/parasitology ; HMGB1 Protein/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Madin Darby Canine Kidney Cells ; Mitochondrial Membranes ; Plasmodium falciparum/genetics ; Plasmodium falciparum/pathogenicity ; Reactive Oxygen Species/metabolism ; Recombinant Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle.
Autorzy:
Badgujar DC; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
Anil A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
Green AE; Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Surve MV; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
Madhavan S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
Beckett A; Division of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Prior IA; Division of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Godsora BK; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
Patil SB; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
More PK; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
Sarkar SG; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
Mitchell A; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
Banerjee R; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
Phale PS; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
Mitchell TJ; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
Neill DR; Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Bhaumik P; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
Banerjee A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
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Źródło:
PLoS pathogens [PLoS Pathog] 2020 Nov 20; Vol. 16 (11), pp. e1009016. Date of Electronic Publication: 2020 Nov 20 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adaptation, Physiological*
Loss of Function Mutation*
Inflammation/*microbiology
Pneumococcal Infections/*microbiology
Streptococcus pneumoniae/*physiology
Streptolysins/*metabolism
Amino Acid Sequence ; Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cell Membrane/microbiology ; Cholesterol/metabolism ; Cytoplasm/microbiology ; Female ; Humans ; Mice ; Models, Structural ; Perforin/genetics ; Perforin/metabolism ; Sequence Alignment ; Streptococcus pneumoniae/genetics ; Streptolysins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A novel homozygous disruptive PRF1 variant (K285Sfs*4) causes very early-onset of familial hemophagocytic lymphohystiocytosis type 2.
Autorzy:
Saettini F; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
Castelli I; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
Provenzi M; Pediatric Unit, Hospital Papa Giovanni XXIII, Bergamo, Italy.
Fazio G; Centro Ricerca Tettamanti, University of Milan Bicocca, Monza, Italy.
Quadri M; Centro Ricerca Tettamanti, University of Milan Bicocca, Monza, Italy.
Cazzaniga G; Centro Ricerca Tettamanti, University of Milan Bicocca, Monza, Italy.; Department of Medicine and Surgery, University of Milan Bicocca, Monza, Italy.
Sala S; Centro Ricerca Tettamanti, University of Milan Bicocca, Monza, Italy.
Dell'Acqua F; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
Sieni E; Department of Paediatric Oncohematology, Meyer Children's University Hospital, Florence, Italy.
Coniglio ML; Department of Paediatric Oncohematology, Meyer Children's University Hospital, Florence, Italy.
Pezzoli L; Molecular Genetics Laboratory, USSD LGM, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Iascone M; Molecular Genetics Laboratory, USSD LGM, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Vendemini F; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
Balduzzi AC; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
Biondi A; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.; Centro Ricerca Tettamanti, University of Milan Bicocca, Monza, Italy.
Rizzari C; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
Bonanomi S; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.
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Źródło:
Pediatric hematology and oncology [Pediatr Hematol Oncol] 2021 Mar; Vol. 38 (2), pp. 174-178. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji:
Case Reports; Letter
MeSH Terms:
Lymphohistiocytosis, Hemophagocytic/*genetics
Perforin/*metabolism
Disease Progression ; Humans ; Infant ; Lymphohistiocytosis, Hemophagocytic/pathology ; Male
Raport
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A proportion of CD4+ T cells from patients with chronic Chagas disease undergo a dysfunctional process, which is partially reversed by benznidazole treatment.
Autorzy:
Pérez-Antón E; Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas; Granada, Spain.
Egui A; Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas; Granada, Spain.
Thomas MC; Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas; Granada, Spain.
Carrilero B; Unidad Regional de Medicina Tropical, Hospital Virgen de la Arrixaca; El Palmar, Murcia, Spain.
Simón M; Unidad Regional de Medicina Tropical, Hospital Virgen de la Arrixaca; El Palmar, Murcia, Spain.
López-Ruz MÁ; Servicio de Medicina Interna, Hospital Virgen de las Nieves; Granada, Spain.
Segovia M; Unidad Regional de Medicina Tropical, Hospital Virgen de la Arrixaca; El Palmar, Murcia, Spain.
López MC; Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas; Granada, Spain.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Feb 04; Vol. 15 (2), pp. e0009059. Date of Electronic Publication: 2021 Feb 04 (Print Publication: 2021).
Typ publikacji:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Antiprotozoal Agents/*administration & dosage
CD4-Positive T-Lymphocytes/*immunology
Chagas Disease/*drug therapy
Nitroimidazoles/*administration & dosage
Trypanosoma cruzi/*drug effects
Adult ; Antibodies, Protozoan/immunology ; Chagas Disease/immunology ; Chagas Disease/parasitology ; Female ; Granzymes/immunology ; Humans ; Interferon-gamma/immunology ; Male ; Middle Aged ; Perforin/immunology ; Spain ; Trypanosoma cruzi/genetics ; Trypanosoma cruzi/immunology ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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