Temat: "Pharmacogenomic Variants" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Identification of pharmacogenetic variants from large scale next generation sequencing data in the Saudi population.
Autorzy:: Goljan E; Clinical Genomics, Centre for Genomic Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.; Saudi Human Genome Program, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Abouelhoda M; Computational Biosciences, Centre for Genomic Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
ElKalioby MM; Saudi Human Genome Program, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.; Computational Biosciences, Centre for Genomic Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Jabaan A; Saudi Human Genome Program, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Alghithi N; Saudi Human Genome Program, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Meyer BF; Clinical Genomics, Centre for Genomic Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.; Saudi Human Genome Program, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Monies D; Clinical Genomics, Centre for Genomic Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.; Saudi Human Genome Program, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2022 Jan 28; Vol. 17 (1), pp. e0263137. Date of Electronic Publication: 2022 Jan 28 (Print Publication: 2022).
Typ publikacji:: Journal Article
MeSH Terms:: Gene Frequency*
Genotype*
High-Throughput Nucleotide Sequencing*
Pharmacogenomic Testing*
Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Female ; Humans ; Male ; Pharmacogenetics ; Saudi Arabia

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Skocz do pozycji: 2.

Tytuł:: Genetic variants related to successful migraine prophylaxis with verapamil.
Autorzy:: Cutrer FM; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Moyer AM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA.
Atkinson EJ; Health Sciences Research, Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Wang L; Health Sciences Research, Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Tian S; Health Sciences Research, Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Wu Y; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Garza I; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Robertson CE; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Huebert CA; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Moore BE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Klein CJ; Department of Neurology, Mayo Clinic, Rochester, MN, USA.; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA.; Pokaż więcej
Źródło:: Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2021 Jun; Vol. 9 (6), pp. e1680. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Migraine Disorders/*genetics
Vasodilator Agents/*therapeutic use
Verapamil/*therapeutic use
Chemoprevention ; Humans ; Migraine Disorders/drug therapy ; Migraine Disorders/prevention & control ; Protein Interaction Maps ; Type C Phospholipases/genetics ; Type C Phospholipases/metabolism ; Vasodilator Agents/administration & dosage ; Verapamil/administration & dosage

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Skocz do pozycji: 3.

Tytuł:: The Role of Genetic Polymorphism and Other Factors on Clopidogrel Resistance (CR) in an Asian Population with Coronary Heart Disease (CHD).
Autorzy:: Akkaif MA; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.
Daud NAA; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.
Sha'aban A; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.
Ng ML; Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang 13200, Malaysia.
Abdul Kader MAS; Department of Cardiology, Penang General Hospital, Pulau Pinang 10990, Malaysia.
Noor DAM; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.
Ibrahim B; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.; Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 Apr 01; Vol. 26 (7). Date of Electronic Publication: 2021 Apr 01.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Clopidogrel/*pharmacology
Coronary Disease/*epidemiology
Coronary Disease/*genetics
Drug Resistance/*genetics
Platelet Aggregation Inhibitors/*pharmacology
Purinergic P2Y Receptor Antagonists/*pharmacology
Alleles ; Asia/epidemiology ; Asian People/genetics ; Clopidogrel/therapeutic use ; Coronary Disease/drug therapy ; Cytochrome P-450 CYP2C19/genetics ; Disease Management ; Drug Interactions ; Female ; Humans ; Male ; Platelet Aggregation Inhibitors/therapeutic use ; Population Surveillance ; Purinergic P2Y Receptor Antagonists/therapeutic use ; Risk Assessment ; Risk Factors

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Skocz do pozycji: 4.

Tytuł:: Impact of gene polymorphisms in drug-metabolizing enzymes and transporters on trough concentrations of rivaroxaban in patients with atrial fibrillation.
Autorzy:: Nakagawa J; Department of Pharmacy, Hirosaki University Hospital, Aomori, Japan.
Kinjo T; Department of Cardiology, Hirosaki University Graduate School of Medicine, Aomori, Japan.
Iizuka M; Department of Pharmacy, Hirosaki University Hospital, Aomori, Japan.
Ueno K; Department of Pharmacy, Hirosaki University Hospital, Aomori, Japan.
Tomita H; Department of Cardiology, Hirosaki University Graduate School of Medicine, Aomori, Japan.
Niioka T; Department of Pharmacy, Hirosaki University Hospital, Aomori, Japan.; Department of Pharmaceutical Science, Hirosaki University Graduate School of Medicine, Aomori, Japan.; Pokaż więcej
Źródło:: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2021 Feb; Vol. 128 (2), pp. 297-304. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji:: Journal Article
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Atrial Fibrillation/*drug therapy
Factor Xa Inhibitors/*blood
Rivaroxaban/*blood
ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Adult ; Aged ; Aged, 80 and over ; Atrial Fibrillation/blood ; Biotransformation ; Cytochrome P-450 CYP2J2 ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Drug Monitoring ; Factor Xa Inhibitors/adverse effects ; Factor Xa Inhibitors/pharmacokinetics ; Female ; Glomerular Filtration Rate ; Humans ; Japan ; Kidney/physiopathology ; Male ; Metabolic Clearance Rate ; Middle Aged ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Pharmacogenetics ; Pharmacogenomic Testing ; Rivaroxaban/adverse effects ; Rivaroxaban/pharmacokinetics ; Treatment Outcome

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Skocz do pozycji: 5.

Tytuł:: The impact of single nucleotide polymorphisms in ADORA2A and ADORA3 genes on the early response to methotrexate and presence of therapy side effects in children with juvenile idiopathic arthritis: Results of a preliminary study.
Autorzy:: Roszkiewicz J; Department of Paediatric Cardiology and Rheumatology, Medical University of Lodz, Lodz, Poland.
Michałek D; Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland.
Ryk A; Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland.
Swacha Z; Clinic of Dermatology, Military Medical Institute, Warsaw, Poland.
Szmyd B; Department of Paediatrics, Oncology and Haematology, Medical University of Lodz, Lodz, Poland.
Smolewska E; Department of Paediatric Cardiology and Rheumatology, Medical University of Lodz, Lodz, Poland.; Pokaż więcej
Źródło:: International journal of rheumatic diseases [Int J Rheum Dis] 2020 Nov; Vol. 23 (11), pp. 1505-1513. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji:: Comparative Study; Journal Article
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Arthritis, Juvenile/*drug therapy
Immunosuppressive Agents/*therapeutic use
Methotrexate/*therapeutic use
Receptor, Adenosine A2A/*genetics
Receptor, Adenosine A3/*genetics
Age Factors ; Arthritis, Juvenile/diagnosis ; Arthritis, Juvenile/genetics ; Child ; Child, Preschool ; Female ; Humans ; Immunosuppressive Agents/adverse effects ; Male ; Methotrexate/adverse effects ; Pharmacogenetics ; Prospective Studies ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome

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Skocz do pozycji: 6.

Tytuł:: Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan province.
Autorzy:: Cheng Y; Department of Blood Transfusion, The First People's Hospital of Yunnan Province, Yunnan Province, Kunming, China.
Dai R; Department of Blood Transfusion, The First People's Hospital of Yunnan Province, Yunnan Province, Kunming, China.
Chen W; Department of Blood Transfusion, The First People's Hospital of Yunnan Province, Yunnan Province, Kunming, China.
Li Q; Department of Blood Transfusion, The First People's Hospital of Yunnan Province, Yunnan Province, Kunming, China.
Zhang C; Department of Blood Transfusion, The First People's Hospital of Yunnan Province, Yunnan Province, Kunming, China.
Yang T; Department of Hematology, The First People's Hospital of Yunnan Province, Yunnan Province, Kunming, China.; Pokaż więcej
Źródło:: Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 Jul; Vol. 8 (7), pp. e1231. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji:: Journal Article
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Population/*genetics
China ; Humans

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Skocz do pozycji: 7.

Tytuł:: Effects of cytochrome P450 oxidoreductase genotypes on the pharmacokinetics of amlodipine in healthy Korean subjects.
Autorzy:: Han JM; College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea.
Yee J; College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea.
Chung JE; College of Pharmacy, Hanyang University, Ansan, Republic of Korea.
Lee KE; College of Pharmacy, Chungbuk National University, Cheongju-si, Republic of Korea.
Park K; Department of Pharmacology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Gwak HS; College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea.; Pokaż więcej
Źródło:: Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 May; Vol. 8 (5), pp. e1201. Date of Electronic Publication: 2020 Mar 05.
Typ publikacji:: Journal Article
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Amlodipine/*blood
Calcium Channel Blockers/*blood
Cytochrome P-450 CYP3A/*genetics
Adult ; Homozygote ; Humans ; Male ; RNA Splicing ; Republic of Korea

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Skocz do pozycji: 8.

Tytuł:: Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients.
Autorzy:: Wang Z; Department of Cardiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Xu Y; Department of Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Zhou H; Department of Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Wang Y; Department of Cardiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Li W; Department of Cardiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Lu Z; Department of Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Jiang Z; Department of Blood Transfusion and Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
Gu X; Department of Blood Transfusion and Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
Zheng H; Department of Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Zeng L; Department of Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Huang P; Department of Cardiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Zhang L; Department of Cardiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Gu X; Department of Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.; Pokaż więcej
Źródło:: Cardiovascular therapeutics [Cardiovasc Ther] 2020 Mar 10; Vol. 2020, pp. 3568608. Date of Electronic Publication: 2020 Mar 10 (Print Publication: 2020).
Typ publikacji:: Journal Article
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Coronary Artery Disease/*genetics
Coronary Artery Disease/*prevention & control
Drug Resistance/*genetics
Immunoglobulins, Intravenous/*therapeutic use
Immunologic Factors/*therapeutic use
Mucocutaneous Lymph Node Syndrome/*drug therapy
Mucocutaneous Lymph Node Syndrome/*genetics
Receptors, Purinergic P2Y12/*genetics
Adolescent ; Case-Control Studies ; Child ; Child, Preschool ; Clinical Decision-Making ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/immunology ; Female ; Gene Frequency ; Heterozygote ; Homozygote ; Humans ; Infant ; Male ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Mucocutaneous Lymph Node Syndrome/immunology ; Patient Selection ; Pharmacogenomic Testing ; Predictive Value of Tests ; Risk Factors

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Skocz do pozycji: 9.

Tytuł:: Genome-wide interaction study reveals age-dependent determinants of responsiveness to inhaled corticosteroids in individuals with asthma.
Autorzy:: Dahlin A; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Sordillo JE; Department of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, United States of America.
McGeachie M; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Kelly RS; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Tantisira KG; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Lutz SM; Department of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, United States of America.
Lasky-Su J; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Wu AC; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Mar 02; Vol. 15 (3), pp. e0229241. Date of Electronic Publication: 2020 Mar 02 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Adrenal Cortex Hormones/*administration & dosage
Anti-Asthmatic Agents/*administration & dosage
Asthma/*drug therapy
ADAM Proteins/genetics ; Administration, Inhalation ; Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Age Factors ; Aged ; Anti-Asthmatic Agents/therapeutic use ; Asthma/genetics ; Case-Control Studies ; Child ; Child, Preschool ; DNA-Binding Proteins/genetics ; Emergency Service, Hospital ; Female ; Genome-Wide Association Study ; Histone Deacetylases/genetics ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Repressor Proteins/genetics ; Transcription Factors/genetics ; Treatment Outcome ; Young Adult

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Skocz do pozycji: 10.

Tytuł:: Pharmacogenetics of amfepramone in healthy Mexican subjects reveals potential markers for tailoring pharmacotherapy of obesity: results of a randomised trial.
Autorzy:: Gómez-Silva M; Forensic Medicine Service, School of Medicine, Autonomous University of Nuevo Leon, Monterrey, Nuevo Leon, Mexico.; Analytical Department of the Research Institute for Clinical and Experimental Pharmacology, Ipharma S.A, Monterrey, Nuevo Leon, Mexico.
Piñeyro-Garza E; Clinical Department of the Research Institute for Clinical and Experimental Pharmacology, Ipharma S.A, Monterrey, Nuevo Leon, Mexico.
Vargas-Zapata R; Quality Assurance Department of the Research Institute for Clinical and Experimental Pharmacology, Ipharma S.A, Monterrey, Nuevo Leon, Mexico.
Gamino-Peña ME; Statistical Department of the Research Institute for Clinical and Experimental Pharmacology, Ipharma S.A, Monterrey, Nuevo Leon, Mexico.
León-García A; Pharmaceutical Research S.A, Mexico City, CDMX, Mexico.
de León MB; Department of Molecular Biology, Center for Biomedical Research of the Northeast, Mexican Institute of Social Security, Monterrey, Nuevo Leon, Mexico.
Llerena A; Clinical Research Center of Health Area, Hospital and Medical School of Extremadura University, Badajoz, Spain.
León-Cachón RBR; Center of Molecular Diagnostics and Personalized Medicine, Department of Basic Sciences, Division of Health Sciences, University of Monterrey, San Pedro Garza Garcia, Nuevo Leon, Mexico. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Nov 28; Vol. 9 (1), pp. 17833. Date of Electronic Publication: 2019 Nov 28.
Typ publikacji:: Journal Article; Randomized Controlled Trial
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Appetite Depressants/*pharmacokinetics
Cytochrome P-450 CYP3A/*genetics
Diethylpropion/*pharmacokinetics
ATP Binding Cassette Transporter, Subfamily B/genetics ; Adult ; Appetite Depressants/administration & dosage ; Appetite Depressants/blood ; Diethylpropion/administration & dosage ; Diethylpropion/blood ; Female ; Humans ; Male ; Metabolic Clearance Rate/genetics ; Middle Aged

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Skocz do pozycji: 11.

Tytuł:: Genome-wide meta-analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans.
Autorzy:: Do AN; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Baldridge AS; Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Wiggins KL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Shah SJ; Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Aslibekyan S; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Tiwari HK; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Limdi N; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Zhi D; School of Biomedical Informatics, University of Texas Health Sciences Center at Houston, Houston, Texas, USA.
Sitlani CM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Taylor KD; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Seattle, Washington, USA.
Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, USA.
Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Rasmussen-Torvik LJ; Department of Preventive Medicine Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Lloyd-Jones D; Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Lange LA; Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA.
Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Kardia SLR; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Mosley TH; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Vasan RS; Departments of Medicine and Preventive Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Arnett DK; College of Public Health, University of Kentucky, Lexington, Kentucky, USA.
Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Pokaż więcej
Źródło:: Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2019 Oct; Vol. 7 (10), pp. e00788. Date of Electronic Publication: 2019 Aug 13.
Typ publikacji:: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Antihypertensive Agents/*therapeutic use
Ventricular Dysfunction, Left/*genetics
Black or African American/genetics ; Black or African American/statistics & numerical data ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Calcium Channel Blockers/therapeutic use ; Humans ; Observational Studies as Topic ; Sodium Chloride Symporter Inhibitors/therapeutic use ; Ventricular Dysfunction, Left/drug therapy ; Ventricular Dysfunction, Left/epidemiology

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Skocz do pozycji: 12.

Tytuł:: Predictive clinical-genetic model of long-term non-response to tumor necrosis factor-alpha inhibitor therapy in spondyloarthritis.
Autorzy:: Polo Y La Borda J; Department of Rheumatology, IDIPHISA, Puerta de Hierro - Segovia de Arana Health Research Institute, Majadahonda, Madrid, Spain.; Department of Rheumatology, University Hospital Rey Juan Carlos, Móstoles, Madrid, Spain.
Campos J; Department of Rheumatology, IDIPHISA, Puerta de Hierro - Segovia de Arana Health Research Institute, Majadahonda, Madrid, Spain.
Sanz J; Department of Rheumatology, IDIPHISA, Puerta de Hierro - Segovia de Arana Health Research Institute, Majadahonda, Madrid, Spain.
Andréu JL; Department of Rheumatology, IDIPHISA, Puerta de Hierro - Segovia de Arana Health Research Institute, Majadahonda, Madrid, Spain.
Mulero J; Department of Rheumatology, IDIPHISA, Puerta de Hierro - Segovia de Arana Health Research Institute, Majadahonda, Madrid, Spain.
Sánchez A; Department of Rheumatology, IDIPHISA, Puerta de Hierro - Segovia de Arana Health Research Institute, Majadahonda, Madrid, Spain.; Pokaż więcej
Źródło:: International journal of rheumatic diseases [Int J Rheum Dis] 2019 Aug; Vol. 22 (8), pp. 1529-1537. Date of Electronic Publication: 2019 May 22.
Typ publikacji:: Journal Article
MeSH Terms:: Models, Genetic*
Pharmacogenomic Testing*
Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Spondylarthritis/*drug therapy
Tumor Necrosis Factor Inhibitors/*therapeutic use
Adult ; Female ; Humans ; I-kappa B Kinase/genetics ; Male ; Middle Aged ; Predictive Value of Tests ; Risk Assessment ; Risk Factors ; Sex Factors ; Spondylarthritis/diagnosis ; Spondylarthritis/genetics ; Spondylarthritis/immunology ; Time Factors ; Treatment Failure ; Tumor Necrosis Factor Inhibitors/adverse effects

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Skocz do pozycji: 13.

Tytuł:: Systems Approach to Identify Common Genes and Pathways Associated with Response to Selective Serotonin Reuptake Inhibitors and Major Depression Risk.
Autorzy:: Srivastava A; Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Delhi 110007, India. .; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. .
Singh P; Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Delhi 110007, India. .; Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) Campus, New Delhi 110007, India. .
Gupta H; Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Delhi 110007, India. .
Kaur H; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. .
Kanojia N; Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Delhi 110007, India. .; Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) Campus, New Delhi 110007, India. .
Guin D; Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Delhi 110007, India. .; Department of Bioinformatics, Delhi Technological University, Shahbad Daulatpur, Main Bawana Road, Delhi 110042, India. .
Sood M; Department of Psychiatry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. .
Chadda RK; Department of Psychiatry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. .
Yadav J; Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Delhi 110007, India. .
Vohora D; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. .
Saso L; Department of Physiology and Pharmacology 'Vittorio Erspamer', Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy. .
Kukreti R; Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Delhi 110007, India. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2019 Apr 23; Vol. 20 (8). Date of Electronic Publication: 2019 Apr 23.
Typ publikacji:: Journal Article; Systematic Review
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Antidepressive Agents/*therapeutic use
Depressive Disorder, Major/*drug therapy
Depressive Disorder, Major/*genetics
Selective Serotonin Reuptake Inhibitors/*therapeutic use
Antidepressive Agents/pharmacology ; Cyclic AMP/metabolism ; Depressive Disorder, Major/metabolism ; Genome-Wide Association Study ; Genomics/methods ; Humans ; Selective Serotonin Reuptake Inhibitors/pharmacology ; Signal Transduction/drug effects ; Workflow

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Skocz do pozycji: 14.

Tytuł:: Long non-coding RNA polymorphisms and prediction of response to chemotherapy based on irinotecan in patients with metastatic colorectal cancer.
Autorzy:: Lampropoulou DI; Second Department of Medical Oncology, Agii Anargiri Cancer Hospital, Athens, Greece.
Aravantinos G; Second Department of Medical Oncology, Agii Anargiri Cancer Hospital, Athens, Greece.
Katifelis H; Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Lazaris F; Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Laschos K; Second Department of Medical Oncology, Agii Anargiri Cancer Hospital, Athens, Greece.
Theodosopoulos T; Second Department of Surgery, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Papadimitriou C; Second Department of Surgery, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Gazouli M; Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Pokaż więcej
Źródło:: Cancer biomarkers : section A of Disease markers [Cancer Biomark] 2019; Vol. 25 (2), pp. 213-221.
Typ publikacji:: Journal Article
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Antineoplastic Agents/*therapeutic use
Colorectal Neoplasms/*drug therapy
Colorectal Neoplasms/*genetics
Irinotecan/*therapeutic use
RNA, Long Noncoding/*genetics
Adult ; Aged ; Aged, 80 and over ; Alleles ; Antineoplastic Agents/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis/drug effects ; Apoptosis/genetics ; Biomarkers, Tumor ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/mortality ; Drug Resistance, Neoplasm/genetics ; Female ; Gene Frequency ; Genotype ; Humans ; Irinotecan/pharmacology ; Male ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Odds Ratio ; Topoisomerase I Inhibitors ; Treatment Outcome

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Skocz do pozycji: 15.

Tytuł:: Whole exome sequencing for the identification of CYP3A7 variants associated with tacrolimus concentrations in kidney transplant patients.
Autorzy:: Sohn M; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.
Kim MG; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.; Graduate school of clinical pharmacy, CHA University, Gyeonggi-do, Republic of Korea.
Han N; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.
Kim IW; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.
Gim J; Department of Biomedical Science, Chosun University, Gwangju, Republic of Korea.
Min SI; Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
Song EY; Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Kim YS; Kidney Research Institute and Department of Medical Science, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jung HS; R&D center, ABION, Inc., Seoul, Republic of Korea.
Shin YK; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.; Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.
Ha J; Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea. .
Oh JM; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2018 Dec 24; Vol. 8 (1), pp. 18064. Date of Electronic Publication: 2018 Dec 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Kidney Transplantation*
Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Cytochrome P-450 CYP3A/*genetics
Immunosuppressive Agents/*blood
Tacrolimus/*blood
Adult ; Female ; Humans ; Male ; Middle Aged ; Transplant Recipients ; Exome Sequencing

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Skocz do pozycji: 16.

Tytuł:: Pharmacogenetic variation influences sensory neuropathy occurrence in Southern Africans treated with stavudine-containing antiretroviral therapy.
Autorzy:: Moketla MB; School of Molecular and Cell Biology, Faculty of Science, University of the Witwatersrand, Johannesburg, South Africa.
Wadley AL; Brain Function Research Group, School of Physiology, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa.
Kamerman P; Brain Function Research Group, School of Physiology, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa.; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, Australia.
de Assis Rosa D; School of Molecular and Cell Biology, Faculty of Science, University of the Witwatersrand, Johannesburg, South Africa.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2018 Oct 01; Vol. 13 (10), pp. e0204111. Date of Electronic Publication: 2018 Oct 01 (Print Publication: 2018).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Anti-HIV Agents/*adverse effects
HIV Infections/*drug therapy
Peripheral Nervous System Diseases/*chemically induced
Stavudine/*adverse effects
Adult ; Anti-HIV Agents/therapeutic use ; Black People ; Case-Control Studies ; Cell Cycle Proteins/genetics ; Female ; HIV Infections/genetics ; Humans ; Male ; Membrane Transport Proteins/genetics ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Middle Aged ; Peripheral Nervous System Diseases/genetics ; Ribonucleotide Reductases/genetics ; SAM Domain and HD Domain-Containing Protein 1/genetics ; South Africa ; Stavudine/therapeutic use

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Skocz do pozycji: 17.

Tytuł:: Possible role of CYP2B6 genetic polymorphisms in ifosfamide-induced encephalopathy: report of three cases.
Autorzy:: Duflot T; Department of Pharmacology, Rouen University Hospital, 1 rue de Germont, F 76000, Rouen, France.; Normandie Univ, UNIROUEN, Inserm U1096, Rouen University, 22 boulevard Gambetta, F 76000, Rouen, France.
Marie-Cardine A; Department of Pediatric Hematology and Oncology, Rouen University Hospital, 1 rue de Germont, F 76000, Rouen, France.
Verstuyft C; Service de Genetique moleculaire, Pharmacogenetique et Hormonologie, CHU Bicêtre, AP-HP, 78 rue du Général Leclerc, 94275, Le Kremlin Bicêtre Cedex, France.
Filhon B; Department of Pediatric Hematology and Oncology, Rouen University Hospital, 1 rue de Germont, F 76000, Rouen, France.
Pereira T; Department of Pharmacology, Rouen University Hospital, 1 rue de Germont, F 76000, Rouen, France.
Massy-Guillemant N; Department of Pharmacology, Rouen University Hospital, 1 rue de Germont, F 76000, Rouen, France.
Joannidès R; Department of Pharmacology, Rouen University Hospital, 1 rue de Germont, F 76000, Rouen, France.; Normandie Univ, UNIROUEN, Inserm U1096, Rouen University, 22 boulevard Gambetta, F 76000, Rouen, France.
Bellien J; Department of Pharmacology, Rouen University Hospital, 1 rue de Germont, F 76000, Rouen, France.; Normandie Univ, UNIROUEN, Inserm U1096, Rouen University, 22 boulevard Gambetta, F 76000, Rouen, France.
Lamoureux F; Department of Pharmacology, Rouen University Hospital, 1 rue de Germont, F 76000, Rouen, France.; Normandie Univ, UNIROUEN, Inserm U1096, Rouen University, 22 boulevard Gambetta, F 76000, Rouen, France.; Pokaż więcej
Źródło:: Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2018 Jun; Vol. 32 (3), pp. 337-342. Date of Electronic Publication: 2018 Jan 25.
Typ publikacji:: Case Reports
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Antineoplastic Agents, Alkylating/*adverse effects
Bone Neoplasms/*drug therapy
Brain Diseases/*chemically induced
Brain Diseases/*genetics
Cytochrome P-450 CYP2B6/*genetics
Ifosfamide/*adverse effects
Osteosarcoma/*drug therapy
Administration, Intravenous ; Adolescent ; Antineoplastic Agents, Alkylating/metabolism ; Brain Diseases/diagnosis ; Brain Diseases/drug therapy ; Child ; Cytochrome P-450 CYP2B6/metabolism ; Female ; Genetic Predisposition to Disease ; Humans ; Ifosfamide/metabolism ; Male ; Methylene Blue/administration & dosage ; Neuroprotective Agents/administration & dosage ; Pharmacogenetics ; Phenotype ; Risk Factors ; Treatment Outcome

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Skocz do pozycji: 18.

Tytuł:: Association between two SCN1A polymorphisms and resistance to sodium channel blocking AEDs: a meta-analysis.
Autorzy:: Bao Y; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Liu X; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Xiao Z; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. .; Pokaż więcej
Źródło:: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2018 Jun; Vol. 39 (6), pp. 1065-1072. Date of Electronic Publication: 2018 Mar 26.
Typ publikacji:: Journal Article; Meta-Analysis
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Anticonvulsants/*therapeutic use
Drug Resistance/*genetics
NAV1.1 Voltage-Gated Sodium Channel/*genetics
Sodium Channel Blockers/*therapeutic use
Genetic Association Studies ; Humans

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Skocz do pozycji: 19.

Tytuł:: Gender-Specific Association Between ABCC2 -24C>T SNP and Reduction in Triglycerides in Chilean Patients Treated With Atorvastatin.
Autorzy:: Prado Y; Center of Molecular Biology and Pharmacogenetics, Department of Basic Sciences, Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco, Chile.
Arencibia A; Center of Molecular Biology and Pharmacogenetics, Department of Basic Sciences, Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco, Chile.
Zambrano T; Center of Molecular Biology and Pharmacogenetics, Department of Basic Sciences, Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco, Chile.
Salazar LA; Center of Molecular Biology and Pharmacogenetics, Department of Basic Sciences, Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco, Chile.; Pokaż więcej
Źródło:: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2018 May; Vol. 122 (5), pp. 517-522. Date of Electronic Publication: 2018 Jan 04.
Typ publikacji:: Journal Article
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Atorvastatin/*therapeutic use
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
Hypercholesterolemia/*drug therapy
Multidrug Resistance-Associated Proteins/*genetics
Triglycerides/*blood
Adult ; Aged ; Biomarkers/blood ; Chile ; Cholesterol/blood ; Down-Regulation ; Female ; Genotype ; Humans ; Hypercholesterolemia/blood ; Hypercholesterolemia/diagnosis ; Hypercholesterolemia/genetics ; Male ; Middle Aged ; Multidrug Resistance-Associated Protein 2 ; Multidrug Resistance-Associated Proteins/metabolism ; Pharmacogenetics ; Phenotype ; Promoter Regions, Genetic ; Sex Factors ; Time Factors ; Treatment Outcome

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Skocz do pozycji: 20.

Tytuł:: Effect of Polymorphisms on the Pharmacokinetics, Pharmacodynamics and Safety of Sertraline in Healthy Volunteers.
Autorzy:: Saiz-Rodríguez M; Clinical Pharmacology Department, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria la Princesa (IP), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Belmonte C; Clinical Pharmacology Department, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria la Princesa (IP), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Román M; Clinical Pharmacology Department, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria la Princesa (IP), Universidad Autónoma de Madrid (UAM), Madrid, Spain.; Plataforma SCReN (Spanish Clinical Research Network), Instituto de Investigación Sanitaria la Princesa (IP), UICEC Hospital Universitario de la Princesa, Madrid, Spain.
Ochoa D; Clinical Pharmacology Department, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria la Princesa (IP), Universidad Autónoma de Madrid (UAM), Madrid, Spain.; Plataforma SCReN (Spanish Clinical Research Network), Instituto de Investigación Sanitaria la Princesa (IP), UICEC Hospital Universitario de la Princesa, Madrid, Spain.
Koller D; Clinical Pharmacology Department, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria la Princesa (IP), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Talegón M; Clinical Pharmacology Department, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria la Princesa (IP), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Ovejero-Benito MC; Clinical Pharmacology Department, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria la Princesa (IP), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
López-Rodríguez R; Clinical Pharmacology Department, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria la Princesa (IP), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Cabaleiro T; Clinical Pharmacology Department, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria la Princesa (IP), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Abad-Santos F; Clinical Pharmacology Department, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria la Princesa (IP), Universidad Autónoma de Madrid (UAM), Madrid, Spain.; Plataforma SCReN (Spanish Clinical Research Network), Instituto de Investigación Sanitaria la Princesa (IP), UICEC Hospital Universitario de la Princesa, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.; Pokaż więcej
Źródło:: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2018 May; Vol. 122 (5), pp. 501-511. Date of Electronic Publication: 2017 Dec 13.
Typ publikacji:: Comparative Study; Journal Article; Randomized Controlled Trial
MeSH Terms:: Pharmacogenomic Variants*
Polymorphism, Single Nucleotide*
Cytochrome P-450 CYP2B6/*genetics
Cytochrome P-450 CYP2C19/*genetics
Selective Serotonin Reuptake Inhibitors/*pharmacokinetics
Sertraline/*pharmacokinetics
Administration, Oral ; Adolescent ; Adult ; Blood Pressure/drug effects ; Cytochrome P-450 CYP2B6/metabolism ; Cytochrome P-450 CYP2C19/metabolism ; Female ; Genotype ; Healthy Volunteers ; Heart Rate/drug effects ; Humans ; Male ; Middle Aged ; Pharmacogenetics ; Phenotype ; Risk Assessment ; Selective Serotonin Reuptake Inhibitors/administration & dosage ; Selective Serotonin Reuptake Inhibitors/adverse effects ; Sertraline/administration & dosage ; Sertraline/adverse effects ; Young Adult

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