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Wyszukujesz frazę ""Pharmacokinetics"" wg kryterium: Temat


Tytuł :
Nonparametric Methods in Population Pharmacokinetics.
Autorzy :
Goutelle S; Hospices Civils de Lyon, Groupement Hospitalier Nord, Service de Pharmacie, Lyon, France.; CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France.; Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Woillard JB; Univ. Limoges, Limoges, France.; INSERM, IPPRITT, Limoges, France.; CHU Limoges, Department of Pharmacology and Toxicology, Limoges, France.
Neely M; Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Laboratory of Applied Pharmacokinetics and Bioinformatics at the Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
Yamada W; Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Bourguignon L; Hospices Civils de Lyon, Groupement Hospitalier Nord, Service de Pharmacie, Lyon, France.; CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France.; Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France.
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Źródło :
Journal of clinical pharmacology [J Clin Pharmacol] 2022 Feb; Vol. 62 (2), pp. 142-157. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Algorithms*
Models, Biological*
Models, Statistical*
Pharmacokinetics*
Software Design*
Age Factors ; Alkynes/pharmacokinetics ; Area Under Curve ; Benzoxazines/pharmacokinetics ; Cyclopropanes/pharmacokinetics ; Humans ; Metabolic Clearance Rate ; Sex Factors
Czasopismo naukowe
Tytuł :
Parametric Approaches in Population Pharmacokinetics.
Autorzy :
Guidi M; Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; Service of Clinical Pharmacology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Csajka C; Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, University of Lausanne, Geneva, Lausanne, Switzerland.
Buclin T; Service of Clinical Pharmacology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
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Źródło :
Journal of clinical pharmacology [J Clin Pharmacol] 2022 Feb; Vol. 62 (2), pp. 125-141. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Algorithms*
Models, Biological*
Models, Statistical*
Pharmacokinetics*
Software Design*
Age Factors ; Alkynes/pharmacokinetics ; Area Under Curve ; Benzoxazines/pharmacokinetics ; Cyclopropanes/pharmacokinetics ; Humans ; Metabolic Clearance Rate ; Sex Factors
Czasopismo naukowe
Tytuł :
Impact of cumulative fluid balance on the pharmacokinetics of extended infusion meropenem in critically ill patients with sepsis.
Autorzy :
Pařízková RČ; Department of Anesthesiology, Resuscitation and Intensive Medicine, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Martínková J; Department of Surgery, University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Havel E; Department of Surgery, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Šafránek P; Department of Surgery, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Kaška M; Department of Surgery, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Astapenko D; Department of Anesthesiology, Resuscitation and Intensive Medicine, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Bezouška J; Department of Surgery, University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
Chládek J; Department of Pharmacology, Charles University, Faculty of Medicine in Hradec Králové, Šimkova 870, 50003, Hradec Králové, Czech Republic. .
Černý V; Department of Anesthesiology, Resuscitation and Intensive Medicine, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 50005, Hradec Králové, Czech Republic.
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Źródło :
Critical care (London, England) [Crit Care] 2021 Jul 17; Vol. 25 (1), pp. 251. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Pharmacokinetics*
Meropenem/*pharmacokinetics
Sepsis/*drug therapy
Water-Electrolyte Balance/*drug effects
APACHE ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/pharmacokinetics ; Bayes Theorem ; Critical Illness/therapy ; Czech Republic ; Female ; Humans ; Intensive Care Units/organization & administration ; Intensive Care Units/statistics & numerical data ; Male ; Meropenem/metabolism ; Middle Aged ; Prospective Studies ; Sepsis/physiopathology
Czasopismo naukowe
Tytuł :
Statistical optimization of bile salt deployed nanovesicles as a potential platform for oral delivery of piperine: accentuated antiviral and anti-inflammatory activity in MERS-CoV challenged mice.
Autorzy :
Zakaria MY; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
Fayad E; Department of Biotechnology, Faculty of Sciences, Taif University, Taif, Saudi Arabia.
Althobaiti F; Department of Biotechnology, Faculty of Sciences, Taif University, Taif, Saudi Arabia.
Zaki I; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
Abu Almaaty AH; Department of Zoology, Faculty of Science, Port Said University, Port Said, Egypt.
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Źródło :
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 1150-1165.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids*/administration & dosage
Alkaloids*/pharmacokinetics
Benzodioxoles*/administration & dosage
Benzodioxoles*/pharmacokinetics
Piperidines*/administration & dosage
Piperidines*/pharmacokinetics
Polyunsaturated Alkamides*/administration & dosage
Polyunsaturated Alkamides*/pharmacokinetics
Bile Acids and Salts/*pharmacokinetics
Drug Delivery Systems/*methods
Middle East Respiratory Syndrome Coronavirus/*drug effects
Administration, Oral ; Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/pharmacokinetics ; Biological Availability ; Cytochrome P-450 Enzyme Inhibitors/administration & dosage ; Cytochrome P-450 Enzyme Inhibitors/pharmacokinetics ; Drug Liberation ; Liposomes ; Mice ; Molecular Docking Simulation ; Nanostructures ; Plants, Medicinal ; Surface-Active Agents/pharmacokinetics
Czasopismo naukowe
Tytuł :
The Effect of Rifampicin on Darunavir, Ritonavir, and Dolutegravir Exposure within Peripheral Blood Mononuclear Cells: a Dose Escalation Study.
Autorzy :
De Nicolò A; Laboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turingrid.7605.4, Turin, Italy.
Calcagno A; Unit of Infectious Diseases, Department of Medical Sciences, University of Turingrid.7605.4, Turin, Italy.
Motta I; Unit of Infectious Diseases, Department of Medical Sciences, University of Turingrid.7605.4, Turin, Italy.
De Vivo E; Laboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turingrid.7605.4, Turin, Italy.
D'Avolio A; Laboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turingrid.7605.4, Turin, Italy.
Di Perri G; Unit of Infectious Diseases, Department of Medical Sciences, University of Turingrid.7605.4, Turin, Italy.
Wiesner L; Division of Clinical Pharmacology, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Ebrahim IE; Division of Clinical Pharmacology, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Maartens G; Division of Clinical Pharmacology, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Orrell C; Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine (IDM) and Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
McIlleron H; Division of Clinical Pharmacology, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 Jun 21; Vol. 66 (6), pp. e0013622. Date of Electronic Publication: 2022 May 18.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents*/pharmacokinetics
HIV Infections*/drug therapy
HIV Protease Inhibitors*/pharmacology
Chromatography, Liquid ; Cross-Over Studies ; Darunavir/pharmacokinetics ; Heterocyclic Compounds, 3-Ring ; Humans ; Leukocytes, Mononuclear ; Oxazines ; Piperazines ; Pyridones ; Rifampin/pharmacokinetics ; Rifampin/therapeutic use ; Ritonavir/pharmacology ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Multicenter Population Pharmacokinetic Study of Unbound Ceftriaxone in Critically Ill Patients.
Autorzy :
Heffernan AJ; University of Queenslandgrid.1003.2 Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia.; School of Medicine, Griffith University, Southport, Queensland, Australia.
Sime FB; University of Queenslandgrid.1003.2 Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia.
Kumta N; University of Queenslandgrid.1003.2 Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia.
Wallis SC; University of Queenslandgrid.1003.2 Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia.
McWhinney B; Department of Chemical Pathology, Pathology Queensland, Herston, Queensland, Australia.
Ungerer J; Department of Chemical Pathology, Pathology Queensland, Herston, Queensland, Australia.; Faculty of Biomedical Science, University of Queenslandgrid.1003.2, St Lucia, Queensland, Australia.
Wong G; University of Queenslandgrid.1003.2 Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia.
Joynt GM; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.
Lipman J; University of Queenslandgrid.1003.2 Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia.; Jamieson Trauma Institute, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.
Roberts JA; University of Queenslandgrid.1003.2 Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia.; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 Jun 21; Vol. 66 (6), pp. e0218921. Date of Electronic Publication: 2022 May 16.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Ceftriaxone*/pharmacokinetics
Critical Illness*
Adult ; Albumins ; Anti-Bacterial Agents/pharmacokinetics ; Creatinine ; Humans ; Microbial Sensitivity Tests ; Monte Carlo Method
Czasopismo naukowe
Tytuł :
Pharmacokinetics and Dose Optimization Strategies of Para-Aminosalicylic Acid in Children with Rifampicin-Resistant Tuberculosis.
Autorzy :
van der Laan LE; Desmond Tutu TB Center, Department of Pediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, South Africa.; Division of Clinical Pharmacology, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Garcia-Prats AJ; Division of Clinical Pharmacology, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Schaaf HS; Division of Clinical Pharmacology, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Chirehwa M; Desmond Tutu TB Center, Department of Pediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, South Africa.
Winckler JL; Division of Clinical Pharmacology, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Mao J; Division of Clinical Pharmacology, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Draper HR; Division of Clinical Pharmacology, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Wiesner L; Desmond Tutu TB Center, Department of Pediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, South Africa.
Norman J; Desmond Tutu TB Center, Department of Pediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, South Africa.
McIlleron H; Desmond Tutu TB Center, Department of Pediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, South Africa.
Donald PR; Division of Clinical Pharmacology, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Hesseling AC; Division of Clinical Pharmacology, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Denti P; Desmond Tutu TB Center, Department of Pediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, South Africa.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 Jun 21; Vol. 66 (6), pp. e0226421. Date of Electronic Publication: 2022 May 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aminosalicylic Acid*/pharmacokinetics
Aminosalicylic Acid*/therapeutic use
HIV Infections*/drug therapy
Tuberculosis, Multidrug-Resistant*/drug therapy
Adult ; Antitubercular Agents/pharmacokinetics ; Antitubercular Agents/therapeutic use ; Child ; Drug Administration Schedule ; Humans ; Rifampin/pharmacokinetics ; Rifampin/therapeutic use
Czasopismo naukowe
Tytuł :
Integrated multiple analytes and semi-mechanistic population pharmacokinetic model of tusamitamab ravtansine, a DM4 anti-CEACAM5 antibody-drug conjugate.
Autorzy :
Pouzin C; Sanofi R&D, Pharmacokinetics Dynamics and Metabolism Department, 1 Avenue Pierre Brossolette, Chilly-Mazarin, 91380, Paris, France. .; Oncology department EMR3738, PKPD modelling unit, University of Claude Bernard Lyon 1, Lyon, France. .
Gibiansky L; QuantPharm LLC, North Potomac, Maryland, USA.
Fagniez N; Sanofi R&D, Pharmacokinetics Dynamics and Metabolism Department, 1 Avenue Pierre Brossolette, Chilly-Mazarin, 91380, Paris, France.
Chadjaa M; Sanofi, Clinical Research, Vitry-sur-seine, Paris, France.
Tod M; Oncology department EMR3738, PKPD modelling unit, University of Claude Bernard Lyon 1, Lyon, France.
Nguyen L; Sanofi R&D, Pharmacokinetics Dynamics and Metabolism Department, 1 Avenue Pierre Brossolette, Chilly-Mazarin, 91380, Paris, France.
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Źródło :
Journal of pharmacokinetics and pharmacodynamics [J Pharmacokinet Pharmacodyn] 2022 Jun; Vol. 49 (3), pp. 381-394. Date of Electronic Publication: 2022 Feb 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents*/pharmacokinetics
Immunoconjugates*/pharmacokinetics
Maytansine*/chemistry
Maytansine*/pharmacokinetics
Antibodies, Monoclonal, Humanized/pharmacokinetics ; Cell Adhesion Molecules ; Humans
Czasopismo naukowe
Tytuł :
Pharmacokinetics, adverse effects and effects on thermal nociception following administration of three doses of codeine to horses.
Autorzy :
Knych HK; K.L. Maddy Equine Analytical Pharmacology Laboratory, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA. .; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA. .
Stucker K; K.L. Maddy Equine Analytical Pharmacology Laboratory, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Gretler SR; K.L. Maddy Equine Analytical Pharmacology Laboratory, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Kass PH; Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, USA.
McKemie DS; K.L. Maddy Equine Analytical Pharmacology Laboratory, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
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Źródło :
BMC veterinary research [BMC Vet Res] 2022 May 25; Vol. 18 (1), pp. 196. Date of Electronic Publication: 2022 May 25.
Typ publikacji :
Journal Article; Randomized Controlled Trial, Veterinary
MeSH Terms :
Codeine*/adverse effects
Codeine*/pharmacokinetics
Glucuronides*/adverse effects
Glucuronides*/pharmacokinetics
Nociception*
Analgesics, Opioid ; Animals ; Horses ; Morphine ; Morphine Derivatives/adverse effects ; Morphine Derivatives/pharmacokinetics
Czasopismo naukowe
Tytuł :
Predicting a therapeutic cut-off serum level of itraconazole in recalcitrant tinea corporis and cruris-A prospective trial.
Autorzy :
Khurana A; Department of Dermatology, Dr Ram Manohar Lohia Hospital and Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, India.
Agarwal A; Department of Dermatology, Dr Ram Manohar Lohia Hospital and Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, India.
Singh A; Medical Mycology Unit, Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi, India.
Sardana K; Department of Dermatology, Dr Ram Manohar Lohia Hospital and Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, India.
Ghadlinge M; Department of Pharmacology, Dr Ram Manohar Lohia Hospital and Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, India.
Agrawal D; Department of Dermatology, Dr Ram Manohar Lohia Hospital and Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, India.
Panesar S; Department of Community Medicine, Dr Ram Manohar Lohia Hospital and Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, India.
Sethia K; Department of Dermatology, Dr Ram Manohar Lohia Hospital and Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, India.
Chowdhary A; Medical Mycology Unit, Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi, India.
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Źródło :
Mycoses [Mycoses] 2021 Dec; Vol. 64 (12), pp. 1480-1488. Date of Electronic Publication: 2021 Oct 09.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Antifungal Agents*/pharmacokinetics
Antifungal Agents*/therapeutic use
Tinea*/drug therapy
Itraconazole/*pharmacokinetics
Humans ; Itraconazole/therapeutic use ; Prospective Studies ; Terbinafine/pharmacokinetics
Czasopismo naukowe
Tytuł :
Effects of cimetidine on ciclosporin population pharmacokinetics and initial dose optimization in aplastic anemia patients.
Autorzy :
Wang DD; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy & School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China. Electronic address: .
He SM; Department of Pharmacy, The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University, Suzhou 215153, China.
Yang Y; Department of Pharmacy, The Affiliated Changzhou Children's Hospital of Nantong University, Changzhou 213003, China.
Mao YZ; Department of Endocrinology, Xuzhou Central Hospital, Xuzhou 221009, China.
Yin D; Department of Pharmacy, The Affiliated Wuxi Maternal and Child Health Hospital of Nanjing Medical University, Wuxi 214002, China.
Zheng ZQ; Department of Pharmacy, The First People's Hosipital of Lianyungang, Lianyungang 222000, China. Electronic address: .
Chen X; Department of Pharmacy, The People's Hospital of Jiangyin, Jiangyin 214400, China; Department of Pharmacy, Children's Hospital of Fudan University, Shanghai 201102, China.. Electronic address: .
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2022 Jul 01; Vol. 174, pp. 106183. Date of Electronic Publication: 2022 Apr 06.
Typ publikacji :
Journal Article
MeSH Terms :
Anemia, Aplastic*/drug therapy
Cyclosporine*/pharmacokinetics
Cyclosporine*/therapeutic use
Cimetidine/therapeutic use ; Humans ; Immunosuppressive Agents/pharmacokinetics ; Immunosuppressive Agents/therapeutic use ; Metabolic Clearance Rate
Czasopismo naukowe
Tytuł :
Macrophage membrane modified baicalin liposomes improve brain targeting for alleviating cerebral ischemia reperfusion injury.
Autorzy :
Long Y; Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. Electronic address: .
Xiang Y; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. Electronic address: .
Liu S; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. Electronic address: .
Zhang Y; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. Electronic address: .
Wan J; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. Electronic address: .
Ci Z; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. Electronic address: .
Cui M; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. Electronic address: .
Shen L; Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. Electronic address: .
Li N; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. Electronic address: .
Guan Y; Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China. Electronic address: .
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Źródło :
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2022 Jul; Vol. 43, pp. 102547. Date of Electronic Publication: 2022 Mar 13.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Ischemia*/drug therapy
Brain Ischemia*/pathology
Neuroprotective Agents*/pharmacokinetics
Neuroprotective Agents*/therapeutic use
Reperfusion Injury*/drug therapy
Animals ; Brain ; Flavonoids ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/pathology ; Liposomes/pharmacokinetics ; Macrophages ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Formulation and Pharmacokinetic Evaluation of Ethyl Cellulose/HPMC-Based Oral Expandable Sustained Release Dosage of Losartan Potassium.
Autorzy :
Wani TU; Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir Srinagar, Kashmir, 190006, India.; Department of Nanotechnology, School of Biological Sciences, University of Kashmir Srinagar, Kashmir, 190006, India.
Fazli AA; Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir Srinagar, Kashmir, 190006, India.
Raza SN; Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir Srinagar, Kashmir, 190006, India.
Khan NA; Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir Srinagar, Kashmir, 190006, India. .
Sheikh FA; Department of Nanotechnology, School of Biological Sciences, University of Kashmir Srinagar, Kashmir, 190006, India. .
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2022 Jun 08; Vol. 23 (5), pp. 160. Date of Electronic Publication: 2022 Jun 08.
Typ publikacji :
Journal Article
MeSH Terms :
Cellulose*/analogs & derivatives
Losartan*/pharmacokinetics
Animals ; Biological Availability ; Delayed-Action Preparations/pharmacokinetics ; Rabbits
Czasopismo naukowe
Tytuł :
Disposition of gentamicin and amikacin in extracorporeal membrane oxygenation using a heparin-coated filter: An in vitro assessment.
Autorzy :
Baud FJ; Département d'Anesthésie et de Réanimation, Adult Intensive Care Unit, Necker Hospital, Paris, France.; University de Paris City, Paris, France.; EA7323 Université de Paris City, Paris, France.
Wasram Jetha-Jamal T; Département d'Anesthésie et de Réanimation, Adult Intensive Care Unit, Necker Hospital, Paris, France.
Vicca S; Laboratoire de Biochimie Necker Hospital, Paris, France.
Raphalen JH; Département d'Anesthésie et de Réanimation, Adult Intensive Care Unit, Necker Hospital, Paris, France.
Lamhaut L; Département d'Anesthésie et de Réanimation, Adult Intensive Care Unit, Necker Hospital, Paris, France.; University de Paris City, Paris, France.
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Źródło :
The International journal of artificial organs [Int J Artif Organs] 2022 Jun; Vol. 45 (6), pp. 588-592. Date of Electronic Publication: 2022 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Amikacin*/pharmacokinetics
Extracorporeal Membrane Oxygenation*/methods
Adsorption ; Anti-Bacterial Agents/pharmacokinetics ; Gentamicins/pharmacokinetics ; Heparin
Czasopismo naukowe
Tytuł :
Prediction of lung exposure to anti-tubercular drugs using plasma pharmacokinetic data: Implications for dose selection.
Autorzy :
Muliaditan M; Clinical Pharmacology & Therapeutics Group, University College London, London, UK.
Teutonico D; Translational Medicine and Early Development, Sanofi R&D, Chilly-Mazarin, France.
Ortega-Muro F; GlaxoSmithKline Global Health Medicines Development Campus, Tres Cantos, Madrid, Spain.
Ferrer S; GlaxoSmithKline Global Health Medicines Development Campus, Tres Cantos, Madrid, Spain.
Della Pasqua O; Clinical Pharmacology & Therapeutics Group, University College London, London, UK; Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Brentford, UK. Electronic address: .
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2022 Jun 01; Vol. 173, pp. 106163. Date of Electronic Publication: 2022 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Ethambutol*/pharmacokinetics
Tuberculosis*/drug therapy
Animals ; Antitubercular Agents/pharmacokinetics ; Humans ; Isoniazid ; Lung ; Mice ; Pyrazinamide
Czasopismo naukowe
Tytuł :
R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini.
Autorzy :
Falcoz C; Certara Strategic Consulting, Princeton, NJ, USA. .
Guzy S; Technion, Haifa, Israel.
Kovač J; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Meister I; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Coulibaly J; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Sayasone S; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.; Lao Institute of Tropical Public Health, Vientiane, Lao PDR.
Wesche D; Certara Strategic Consulting, Princeton, NJ, USA.
Lin YW; Certara Strategic Consulting, Princeton, NJ, USA.; Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.
Keiser J; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
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Źródło :
Journal of pharmacokinetics and pharmacodynamics [J Pharmacokinet Pharmacodyn] 2022 Jun; Vol. 49 (3), pp. 293-310. Date of Electronic Publication: 2022 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anthelmintics*/pharmacokinetics
Anthelmintics*/therapeutic use
Opisthorchiasis*/drug therapy
Opisthorchis*/metabolism
Schistosomiasis*/drug therapy
Adult ; Animals ; Child ; Child, Preschool ; Chromatography, Liquid ; Humans ; Laos ; Praziquantel/pharmacokinetics ; Praziquantel/therapeutic use ; Schistosoma mansoni/metabolism ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Pharmacokinetics of First-Line Drugs in Children With Tuberculosis, Using World Health Organization-Recommended Weight Band Doses and Formulations.
Autorzy :
Chabala C; University of Zambia, School of Medicine, Department of Paediatrics, Lusaka, Zambia.; University of Cape Town, Faculty of Health Sciences, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa.; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia.
Turkova A; Medical Research Council-Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London, United Kingdom.
Hesseling AC; University of Stellenbosch, Desmond Tutu Tuberculosis Centre, Cape Town, South Africa.
Zimba KM; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia.
van der Zalm M; University of Stellenbosch, Desmond Tutu Tuberculosis Centre, Cape Town, South Africa.
Kapasa M; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia.
Palmer M; University of Stellenbosch, Desmond Tutu Tuberculosis Centre, Cape Town, South Africa.
Chirehwa M; University of Cape Town, Faculty of Health Sciences, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa.
Wiesner L; University of Cape Town, Faculty of Health Sciences, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa.
Wobudeya E; Makerere University-Johns Hopkins University Care Ltd, Kampala, Uganda.
Kinikar A; Byramjee Jeejeebhoy Government Medical College, Pune, India.
Mave V; Byramjee Jeejeebhoy Government Medical College, Pune, India.
Hissar S; India Council of Medical Research, National Institute for Research in Tuberculosis, Chennai, India.
Choo L; Medical Research Council-Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London, United Kingdom.
LeBeau K; Medical Research Council-Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London, United Kingdom.
Mulenga V; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia.
Aarnoutse R; Radboud University Medical Center, Nijmegen, The Netherlands.
Gibb D; Medical Research Council-Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London, United Kingdom.
McIlleron H; University of Cape Town, Faculty of Health Sciences, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
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Źródło :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2022 May 30; Vol. 74 (10), pp. 1767-1775.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Pyrazinamide*/pharmacokinetics
Tuberculosis*/drug therapy
Adult ; Antitubercular Agents/therapeutic use ; Child ; Child, Preschool ; Ethambutol/therapeutic use ; Female ; Humans ; Isoniazid/pharmacokinetics ; Isoniazid/therapeutic use ; Male ; Rifampin/therapeutic use ; World Health Organization
Czasopismo naukowe
Tytuł :
Drug concentration at the site of disease in children with pulmonary tuberculosis.
Autorzy :
Lopez-Varela E; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic - Universidad de Barcelona, Barcelona, Spain.
Abulfathi AA; Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; Department of Clinical Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medical Sciences, University of Maiduguri, Maiduguri, Nigeria.; Center for Pharmacometrics & Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, USA.
Strydom N; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, 94158, USA.
Goussard P; Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
van Wyk AC; Division of Anatomical Pathology, Tygerberg Hospital, National Health Laboratory Service, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Demers AM; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; Service de microbiologie, Département clinique de médecine de laboratoire, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Canada.
Deventer AV; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Garcia-Prats AJ; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
van der Merwe J; Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Zimmerman M; Center for Discovery and Innovation, Hackensack Meridian Health, New Jersey, USA, and Department of Medical Sciences, Hackensack School of Medicine, Nutley, New Jersey, USA.
Carter CL; Center for Discovery and Innovation, Hackensack Meridian Health, New Jersey, USA, and Department of Medical Sciences, Hackensack School of Medicine, Nutley, New Jersey, USA.; Department of Pathology, Hackensack School of Medicine, Nutley, New Jersey 07110, USA.
Janson J; Division of Cardiothoracic Surgery, Department of Surgery, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Morrison J; Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Reuter H; Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Decloedt EH; Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Seddon JA; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; Department of Infectious Diseases, Imperial College London, London, UK.
Svensson EM; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Warren R; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Savic RM; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, 94158, USA.
Dartois V; Center for Discovery and Innovation, Hackensack Meridian Health, New Jersey, USA, and Department of Medical Sciences, Hackensack School of Medicine, Nutley, New Jersey, USA.
Hesseling AC; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
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Źródło :
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2022 May 29; Vol. 77 (6), pp. 1710-1719.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Isoniazid*/pharmacokinetics
Tuberculosis, Pulmonary*/drug therapy
Adult ; Antitubercular Agents/pharmacokinetics ; Antitubercular Agents/therapeutic use ; Child ; Ethambutol/pharmacokinetics ; Humans ; Infant ; Pyrazinamide/pharmacokinetics ; South Africa
Czasopismo naukowe
Tytuł :
Pharmacokinetics, Prostate Distribution and Metabolic Characteristics of Four Representative Flavones after Oral Administration of the Aerial Part of Glycyrrhiza uralensis in Rats.
Autorzy :
Liu H; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Chang G; Beijing Wehand-Bio Pharmaceutical Co., Ltd., Beijing 102629, China.
Wang W; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.; Engineering Research Center of Good Agricultural Practice for Chinese Crude Drugs, Ministry of Education, Beijing 100102, China.
Ji Z; Xinjiang Key Laboratory for Reserch of Licorice and Products, Korla 841011, China.; Xinjiang Quanan Pharmaceutical Co., Ltd., Korla 841011, China.
Cui J; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Peng Y; Xinjiang Key Laboratory for Reserch of Licorice and Products, Korla 841011, China.; Xinjiang Quanan Pharmaceutical Co., Ltd., Korla 841011, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2022 May 19; Vol. 27 (10). Date of Electronic Publication: 2022 May 19.
Typ publikacji :
Journal Article
MeSH Terms :
Flavones*/pharmacokinetics
Glycyrrhiza uralensis*
Administration, Oral ; Animals ; Flavonoids/pharmacokinetics ; Kaempferols ; Luteolin ; Male ; Plant Components, Aerial ; Prostate ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry/methods
Czasopismo naukowe
Tytuł :
A Pharmacokinetic Analysis of Tobramycin in Patients Less than Five Years of Age with Cystic Fibrosis: Assessment of Target Attainment with Extended-Interval Dosing through Simulation.
Autorzy :
Downes KJ; Division of Infectious, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Grim A; Department of Pharmacy, Texas Children's Hospital, Houston, Texas, USA.
Shanley L; Clinical Pharmacy, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Rubenstein RC; Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Zuppa AF; Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Anesthesiology and Critical Care, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Gastonguay MR; Metrum Research Group, Tariffville, Connecticut, USA.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 May 17; Vol. 66 (5), pp. e0237721. Date of Electronic Publication: 2022 Apr 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cystic Fibrosis*/drug therapy
Tobramycin*/pharmacokinetics
Adolescent ; Adult ; Anti-Bacterial Agents/pharmacokinetics ; Child ; Computer Simulation ; Humans ; Retrospective Studies
Czasopismo naukowe

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