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Tytuł :
Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening.
Autorzy :
Ye D; Drug Metabolism & Pharmacokinetics-Bioanalytics LU, AbbVie Deutschland GmbH & Co KG, Knollstraße 50, 67061, Ludwigshafen, Germany.
Harder A; Drug Metabolism & Pharmacokinetics-Bioanalytics LU, AbbVie Deutschland GmbH & Co KG, Knollstraße 50, 67061, Ludwigshafen, Germany.; Current Address: Global Marketing and Sales, B. Braun Melsungen AG, Plant P Pfieffewiesen, 34212, Melsungen, Germany.
Fang Z; Drug Metabolism & Pharmacokinetics-Bioanalytics LU, AbbVie Deutschland GmbH & Co KG, Knollstraße 50, 67061, Ludwigshafen, Germany.; Current Address: NCE Drug Metabolism & Pharmacokinetics, Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
Weinheimer M; Drug Metabolism & Pharmacokinetics-Bioanalytics LU, AbbVie Deutschland GmbH & Co KG, Knollstraße 50, 67061, Ludwigshafen, Germany.
Laplanche L; Drug Metabolism & Pharmacokinetics-Bioanalytics LU, AbbVie Deutschland GmbH & Co KG, Knollstraße 50, 67061, Ludwigshafen, Germany.
Mezler M; Drug Metabolism & Pharmacokinetics-Bioanalytics LU, AbbVie Deutschland GmbH & Co KG, Knollstraße 50, 67061, Ludwigshafen, Germany. .
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Źródło :
Pharmaceutical research [Pharm Res] 2020 Sep 11; Vol. 37 (10), pp. 194. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Pharmacokinetics*
ATP Binding Cassette Transporter, Subfamily B, Member 1/*deficiency
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Drug Evaluation, Preclinical/*methods
Neoplasm Proteins/*metabolism
ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 2/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; Animals ; Blood-Brain Barrier/metabolism ; Brain/metabolism ; Caco-2 Cells ; Cell Membrane Permeability ; Dibenzocycloheptenes/pharmacology ; Diketopiperazines/pharmacology ; Dogs ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Humans ; Madin Darby Canine Kidney Cells ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/genetics ; Prazosin/pharmacokinetics ; Quinidine/pharmacokinetics ; Quinolines/pharmacology ; Substrate Specificity ; Transfection
Czasopismo naukowe
Tytuł :
Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips.
Autorzy :
Herland A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Division of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden.; AIMES, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
Maoz BM; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
Das D; CFD Research Corporation, Huntsville, AL, USA.
Somayaji MR; CFD Research Corporation, Huntsville, AL, USA.
Prantil-Baun R; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Novak R; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Cronce M; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Huffstater T; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Jeanty SSF; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Ingram M; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Chalkiadaki A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Benson Chou D; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Marquez S; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Delahanty A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Jalili-Firoozinezhad S; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Department of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Portugal Graduate Program, Universidade de Lisboa, Lisbon, Portugal.
Milton Y; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Sontheimer-Phelps A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Faculty of Biology, University of Freiburg, Freiburg, Germany.
Swenor B; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Levy O; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Parker KK; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Przekwas A; CFD Research Corporation, Huntsville, AL, USA.
Ingber DE; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. .; Division of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden. .; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature biomedical engineering [Nat Biomed Eng] 2020 Apr; Vol. 4 (4), pp. 421-436. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Lab-On-A-Chip Devices*
Pharmaceutical Preparations*/administration & dosage
Pharmaceutical Preparations*/metabolism
Pharmacokinetics*
Microfluidics/*methods
Animals ; Cisplatin/pharmacokinetics ; Drug Design ; Humans ; In Vitro Techniques ; Liver/metabolism ; Microfluidics/instrumentation ; Models, Biological ; Nicotine/pharmacokinetics
Czasopismo naukowe
Tytuł :
Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia.
Autorzy :
Kitoh H; Department of Orthopaedic Surgery, Aichi Children's Health and Medical Center, Obu, Aichi, Japan.; Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan.
Matsushita M; Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan.
Mishima K; Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan.
Nagata T; Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan.
Kamiya Y; Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan.
Ueda K; Department of Advanced Medicine, Nagoya University Hospital, Showa-ku, Nagoya, Aichi, Japan.
Kuwatsuka Y; Department of Advanced Medicine, Nagoya University Hospital, Showa-ku, Nagoya, Aichi, Japan.
Morikawa H; Ina Research Inc, Ina, Nagano, Japan.
Nakai Y; Department of Advanced Medicine, Nagoya University Hospital, Showa-ku, Nagoya, Aichi, Japan.
Ishiguro N; Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan.
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Źródło :
PloS one [PLoS One] 2020 Apr 13; Vol. 15 (4), pp. e0229639. Date of Electronic Publication: 2020 Apr 13 (Print Publication: 2020).
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Pharmacokinetics*
Achondroplasia/*drug therapy
Meclizine/*administration & dosage
Meclizine/*pharmacokinetics
Achondroplasia/blood ; Achondroplasia/pathology ; Administration, Oral ; Animals ; Child ; Child, Preschool ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Humans ; Male ; Meclizine/blood ; Mice
Czasopismo naukowe
Tytuł :
Psychosis Treatment During COVID-19 Pandemic and the Potential Role of Phenothiazines: A Call for Research Studies.
Autorzy :
Ruiz de Pellón Santamaría Á; Department of Psychiatry, Donostia University Hospital, Donostia, Guipúzcoa, Spain .
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Źródło :
Journal of clinical psychopharmacology [J Clin Psychopharmacol] 2020 Nov/Dec; Vol. 40 (6), pp. 641-642.
Typ publikacji :
Letter
MeSH Terms :
Betacoronavirus*/drug effects
Betacoronavirus*/physiology
Chlorpromazine*/pharmacokinetics
Chlorpromazine*/therapeutic use
Lung*/drug effects
Lung*/metabolism
Phenothiazines*/pharmacokinetics
Phenothiazines*/therapeutic use
Coronavirus Infections/*drug therapy
Pneumonia, Viral/*drug therapy
Psychotic Disorders/*drug therapy
Antipsychotic Agents/pharmacokinetics ; Antipsychotic Agents/therapeutic use ; Biological Availability ; Biomedical Research ; Coronavirus Infections/metabolism ; Drug Repositioning/methods ; Humans ; Maximum Allowable Concentration ; Needs Assessment ; Pandemics ; Pneumonia, Viral/metabolism ; Tissue Distribution
SCR Disease Name :
COVID-19
Opinia redakcyjna
Tytuł :
QT Interval Prolongation Under Hydroxychloroquine/Azithromycin Association for Inpatients With SARS-CoV-2 Lower Respiratory Tract Infection.
Autorzy :
Bun SS; Cardiology Department, Pasteur University Hospital, Nice, France.
Taghji P; Cardiology Department, Clinique la Casamance, Aubagne, France.
Courjon J; Infectious Diseases Department, Archet University Hospital, Nice, France.
Squara F; Cardiology Department, Pasteur University Hospital, Nice, France.
Scarlatti D; Cardiology Department, Pasteur University Hospital, Nice, France.
Theodore G; Cardiology Department, Pasteur University Hospital, Nice, France.
Baudouy D; Cardiology Department, Pasteur University Hospital, Nice, France.
Sartre B; Cardiology Department, Pasteur University Hospital, Nice, France.
Labbaoui M; Cardiology Department, Pasteur University Hospital, Nice, France.
Dellamonica J; Medical Intensive Care Unit, Archet University Hospital, Nice, France.
Doyen D; Medical Intensive Care Unit, Archet University Hospital, Nice, France.
Marquette CH; Department of Respiratory Medicine, Pasteur University Hospital, Nice, France.
Levraut J; Department of Emergency Medicine, Pasteur University Hospital, Nice, France.
Esnault V; Nephrology Department, Pasteur University Hospital, Nice, France.
Bun SS; Pharmacy Faculty, CNRS, IRD, IMBE, Aix Marseille University, Marseille, France.; Pharmacy Department, CHU Nord, APHM, Marseille, France.
Ferrari E; Cardiology Department, Pasteur University Hospital, Nice, France.
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Źródło :
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2020 Nov; Vol. 108 (5), pp. 1090-1097. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article
MeSH Terms :
Azithromycin*/administration & dosage
Azithromycin*/adverse effects
Azithromycin*/pharmacokinetics
Coronavirus Infections*/diagnosis
Coronavirus Infections*/drug therapy
Coronavirus Infections*/physiopathology
Drug Monitoring*/instrumentation
Drug Monitoring*/methods
Drug Monitoring*/standards
Hydroxychloroquine*/administration & dosage
Hydroxychloroquine*/adverse effects
Hydroxychloroquine*/pharmacokinetics
Long QT Syndrome*/chemically induced
Long QT Syndrome*/diagnosis
Pandemics*
Electrocardiography/*methods
Pneumonia, Viral/*drug therapy
Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/adverse effects ; Anti-Infective Agents/pharmacokinetics ; Betacoronavirus/isolation & purification ; Dimensional Measurement Accuracy ; Female ; Humans ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/physiopathology ; Torsades de Pointes/chemically induced ; Torsades de Pointes/prevention & control
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Direct comparison of two extended half-life PEGylated recombinant FVIII products: a randomized, crossover pharmacokinetic study in patients with severe hemophilia A.
Autorzy :
Solms A; Clinical Pharmacometrics, Pharmaceuticals Research & Development, Bayer AG, 13353, Berlin, Germany. .
Shah A; Bayer, Whippany, NJ, USA.
Berntorp E; Centre for Thrombosis and Haemostasis, Lund University, Skåne University Hospital, Malmö, Sweden.
Tiede A; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hanover, Germany.
Iorio A; McMaster-Bayer Endowed Research Chair in Clinical Epidemiology of Congenital Bleeding Disorders, Department of Medicine, McMaster University, Hamilton, Canada.; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada.
Linardi C; Bayer, Whippany, NJ, USA.
Ahsman M; LAP&P Consultants BV, Leiden, the Netherlands.
Mancuso ME; Center for Thrombosis and Hemorrhagic Diseases, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Zhivkov T; Specialized Hospital for Active Treatment, Sofia, Bulgaria.
Lissitchkov T; Specialized Hospital for Active Treatment, Sofia, Bulgaria.
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Źródło :
Annals of hematology [Ann Hematol] 2020 Nov; Vol. 99 (11), pp. 2689-2698. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial
MeSH Terms :
Factor VIII*/administration & dosage
Factor VIII*/pharmacokinetics
Hemophilia A*/blood
Hemophilia A*/drug therapy
Adolescent ; Adult ; Aged ; Cross-Over Studies ; Half-Life ; Humans ; Male ; Middle Aged ; Polyethylene Glycols ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/pharmacokinetics
Czasopismo naukowe
Tytuł :
Ketoconazole-loaded poly-(lactic acid) nanoparticles: Characterization and improvement of antifungal efficacy in vitro against Candida and dermatophytes.
Autorzy :
Endo EH; Post-Graduate Program in Pharmaceutical Science, State University of Maringá, avenue Colombo, 5790, Maringá 87020-900, Paraná, Brazil. Electronic address: .
Makimori RY; Post-Graduate Program in Pharmaceutical Science, State University of Maringá, avenue Colombo, 5790, Maringá 87020-900, Paraná, Brazil.
Companhoni MVP; Post-Graduate Program in Pharmaceutical Science, State University of Maringá, avenue Colombo, 5790, Maringá 87020-900, Paraná, Brazil.
Ueda-Nakamura T; Department of Basic Health Sciences, State University of Maringá, avenue Colombo, 5790, Maringá 87020-900, Paraná, Brazil.
Nakamura CV; Department of Basic Health Sciences, State University of Maringá, avenue Colombo, 5790, Maringá 87020-900, Paraná, Brazil.
Dias Filho BP; Department of Basic Health Sciences, State University of Maringá, avenue Colombo, 5790, Maringá 87020-900, Paraná, Brazil.
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Źródło :
Journal de mycologie medicale [J Mycol Med] 2020 Sep; Vol. 30 (3), pp. 101003. Date of Electronic Publication: 2020 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Carriers*/chemical synthesis
Drug Carriers*/chemistry
Drug Carriers*/pharmacokinetics
Antifungal Agents/*administration & dosage
Arthrodermataceae/*drug effects
Candida/*drug effects
Ketoconazole/*administration & dosage
Nanoparticles/*chemistry
Polyesters/*chemistry
Antifungal Agents/pharmacokinetics ; Arthrodermataceae/physiology ; Biofilms/drug effects ; Candida/physiology ; Drug Compounding/methods ; Drug Delivery Systems/methods ; Drug Liberation ; Humans ; Ketoconazole/pharmacokinetics ; Materials Testing ; Microbial Sensitivity Tests ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Vulnerable plaque imaging using F-sodium fluoride positron emission tomography.
Autorzy :
Kwiecinski J; Department of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, USA.; Department of Interventional Cardiology and Angiology, Institute of Cardiology, Alpejska 42, 04-628 Warsaw, Poland.
Slomka PJ; Department of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, USA.
Dweck MR; BHF Centre for Cardiovascular Science, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
Newby DE; BHF Centre for Cardiovascular Science, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
Berman DS; Department of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, USA.
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Źródło :
The British journal of radiology [Br J Radiol] 2020 Sep 01; Vol. 93 (1113), pp. 20190797. Date of Electronic Publication: 2019 Dec 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Fluorine Radioisotopes*/pharmacokinetics
Radiopharmaceuticals*/pharmacokinetics
Sodium Radioisotopes*/pharmacokinetics
Coronary Artery Disease/*diagnostic imaging
Plaque, Atherosclerotic/*diagnostic imaging
Positron-Emission Tomography/*methods
Vascular Calcification/*diagnostic imaging
Computed Tomography Angiography ; Coronary Artery Disease/metabolism ; Humans ; Movement ; Organ Motion ; Plaque, Atherosclerotic/metabolism ; Positron Emission Tomography Computed Tomography ; Risk Factors ; Sodium Fluoride/pharmacokinetics ; Vascular Calcification/metabolism
Czasopismo naukowe
Tytuł :
A phase I study of pharmacokinetics of trastuzumab emtansine in Chinese patients with locally advanced inoperable or metastatic human epidermal growth factor receptor 2-positive breast cancer who have received prior trastuzumab-based therapy.
Autorzy :
Ji D; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Shen W; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Zhang J; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Cao J; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Li W; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Lam LH; Genentech, Inc., South San Francisco, CA, USA.
Wu F; Roche (China) Holding Ltd., Shanghai, People's Republic of China.
Wang B; Genentech, Inc., South San Francisco, CA, USA.
Li Z; Genentech, Inc., South San Francisco, CA, USA.
Sun G; Roche (China) Holding Ltd., Shanghai, People's Republic of China.
Hu X; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Chen SC; Genentech, Inc., South San Francisco, CA, USA.
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Oct 30; Vol. 99 (44), pp. e22886.
Typ publikacji :
Clinical Trial; Clinical Trial, Phase I; Journal Article
MeSH Terms :
Trastuzumab*/administration & dosage
Trastuzumab*/adverse effects
Trastuzumab*/pharmacokinetics
Breast Neoplasms/*drug therapy
Receptor, ErbB-2/*analysis
Antineoplastic Agents, Immunological/administration & dosage ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/pharmacokinetics ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology ; China ; Drug Monitoring/methods ; Female ; Humans ; Middle Aged ; Neoplasm Staging ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Uptake, accumulation, and translocation mechanisms of steroid estrogens in plants.
Autorzy :
Chen X; State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, 100875 Beijing, China.
Li Y; State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, 100875 Beijing, China. Electronic address: .
Jiang L; Beijing University of Agriculture, Beijing 102206, China.
Hu B; State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, 100875 Beijing, China.
Wang L; State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, 100875 Beijing, China.
An S; State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, 100875 Beijing, China.
Zhang X; Beijing Soil and Fertilizer Extension Service Station, Beijing 100029, China.
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Jan 20; Vol. 753, pp. 141979. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Estradiol*/pharmacokinetics
Estrogens*/pharmacokinetics
Plants*
Soil Pollutants*/pharmacokinetics
Adsorption ; Ethinyl Estradiol/pharmacokinetics ; Humans ; Sewage
Czasopismo naukowe
Tytuł :
In vitro Pharmacokinetic Cell Culture System that Simulates Physiologic Drug and Nanoparticle Exposure to Macrophages.
Autorzy :
Kutscher HL; Translational Pharmacology Research Core, NYS Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, New York, 14203, USA.; Institute for Lasers, Photonics and Biophotonics, University at Buffalo, Buffalo, New York, 14260, USA.; Department of Anesthesiology, University at Buffalo, Buffalo, New York, 14203, USA.
Morse GD; Translational Pharmacology Research Core, NYS Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, New York, 14203, USA.; Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, 14214, USA.
Prasad PN; Institute for Lasers, Photonics and Biophotonics, University at Buffalo, Buffalo, New York, 14260, USA.
Reynolds JL; Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, 14203, USA. .
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Źródło :
Pharmaceutical research [Pharm Res] 2019 Feb 01; Vol. 36 (3), pp. 44. Date of Electronic Publication: 2019 Feb 01.
Typ publikacji :
Journal Article
MeSH Terms :
Pharmacokinetics*
Cell Culture Techniques/*methods
Drug Carriers/*pharmacokinetics
Macrophages/*drug effects
Macrophages/*metabolism
Nanoparticles/*administration & dosage
Nanoparticles/*metabolism
Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacokinetics ; Cell Culture Techniques/instrumentation ; Cell Line ; Drug Carriers/administration & dosage ; Drug Delivery Systems ; Humans ; Nanoparticles/chemistry ; Rifampin/administration & dosage ; Rifampin/pharmacokinetics
Czasopismo naukowe
Tytuł :
Estimating a drug's elimination rate-constant or half-life from a single blood sample: a practical approach with particular benefits for critically ill/vulnerable patients.
Autorzy :
Scutt G; School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK.
Allen M; School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK.
Waxman D; Centre for Computational Systems Biology, ISTBI, Fudan University, Shanghai, PR China. Electronic address: .
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Źródło :
Bio Systems [Biosystems] 2019 Oct; Vol. 184, pp. 103996. Date of Electronic Publication: 2019 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolic Clearance Rate*
Pharmacokinetics*
Critical Illness/*therapy
Pharmaceutical Preparations/*metabolism
Algorithms ; Cyclosporine/administration & dosage ; Cyclosporine/blood ; Cyclosporine/pharmacokinetics ; Drug Monitoring/methods ; Half-Life ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/blood ; Immunosuppressive Agents/pharmacokinetics ; Models, Theoretical ; Pharmaceutical Preparations/administration & dosage ; Software
Czasopismo naukowe
Tytuł :
Moringa oleifera leaf extract induces vasorelaxation via endothelium-dependent hyperpolarization and calcium channel blockade in mesenteric arterial beds isolated from L-NAME hypertensive rats.
Autorzy :
Aekthammarat D; Department of Pharmacology, Faculty of Medicine, Khon Kaen University , Khon Kaen, Thailand.; Cardiovascular Research Group, Khon Kaen University , Khon Kaen, Thailand.
Pannangpetch P; Department of Pharmacology, Faculty of Medicine, Khon Kaen University , Khon Kaen, Thailand.; Cardiovascular Research Group, Khon Kaen University , Khon Kaen, Thailand.
Tangsucharit P; Department of Pharmacology, Faculty of Medicine, Khon Kaen University , Khon Kaen, Thailand.; Cardiovascular Research Group, Khon Kaen University , Khon Kaen, Thailand.
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Źródło :
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2020 Aug 17; Vol. 42 (6), pp. 490-501. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium Channel Blockers*/administration & dosage
Calcium Channel Blockers*/pharmacokinetics
Endothelium, Vascular*/drug effects
Endothelium, Vascular*/metabolism
Endothelium, Vascular*/physiopathology
Hypertension*/drug therapy
Hypertension*/metabolism
Hypertension*/physiopathology
Mesenteric Arteries*/drug effects
Mesenteric Arteries*/physiopathology
Moringa oleifera*
Plant Extracts*/administration & dosage
Plant Extracts*/pharmacokinetics
Phytotherapy/*methods
Vasodilation/*drug effects
Animals ; Biological Factors/metabolism ; Male ; Rats ; Treatment Outcome ; Vasodilator Agents/administration & dosage ; Vasodilator Agents/pharmacokinetics
Czasopismo naukowe
Tytuł :
Molecular Imaging of Inflammation in a Mouse Model of Atherosclerosis Using a Zirconium-89-Labeled Probe.
Autorzy :
Ahmed M; Department of Molecular Medicine and Surgery, Center for Molecular Medicine, BioClinicum, Karolinska Institutet, Stockholm, SE 17176, Sweden.; Department of Cardiology, Karolinska University Hospital, Stockholm, SE 17176, Sweden.
Tegnebratt T; Department of Clinical Neuroscience, BioClinicum, Karolinska Institutet, Stockholm, SE 17176, Sweden.; Department of Radiopharmacy, Karolinska University Hospital, Stockholm, SE 17176, Sweden.
Tran TA; Department of Clinical Neuroscience, BioClinicum, Karolinska Institutet, Stockholm, SE 17176, Sweden.; Department of Radiopharmacy, Karolinska University Hospital, Stockholm, SE 17176, Sweden.
Lu L; Department of Clinical Neuroscience, BioClinicum, Karolinska Institutet, Stockholm, SE 17176, Sweden.; Department of Radiopharmacy, Karolinska University Hospital, Stockholm, SE 17176, Sweden.
Damberg P; Department of Clinical Neuroscience, BioClinicum, Karolinska Institutet, Stockholm, SE 17176, Sweden.
Gisterå A; Department of Medicine Solna, Center for Molecular Medicine, BioClinicum, Karolinska Institutet, Stockholm, SE 17176, Sweden.
Tarnawski L; Department of Medicine Solna, Center for Molecular Medicine, BioClinicum, Karolinska Institutet, Stockholm, SE 17176, Sweden.
Bone D; Department of Molecular Medicine and Surgery, Center for Molecular Medicine, BioClinicum, Karolinska Institutet, Stockholm, SE 17176, Sweden.; Department of Clinical Physiology, Karolinska University Hospital, Stockholm, SE 17176, Sweden.
Hedin U; Department of Molecular Medicine and Surgery, Center for Molecular Medicine, BioClinicum, Karolinska Institutet, Stockholm, SE 17176, Sweden.; Department of Vascular Surgery, Karolinska University Hospital, Stockholm, SE 17176, Sweden.
Eriksson P; Department of Medicine Solna, Center for Molecular Medicine, BioClinicum, Karolinska Institutet, Stockholm, SE 17176, Sweden.
Holmin S; Department of Clinical Neuroscience, BioClinicum, Karolinska Institutet, Stockholm, SE 17176, Sweden.; Department of Neuroradiology, Karolinska University Hospital, Stockholm, SE 17176, Sweden.
Gustafsson B; Department of Molecular Medicine and Surgery, Center for Molecular Medicine, BioClinicum, Karolinska Institutet, Stockholm, SE 17176, Sweden.
Caidahl K; Department of Molecular Medicine and Surgery, Center for Molecular Medicine, BioClinicum, Karolinska Institutet, Stockholm, SE 17176, Sweden.; Department of Clinical Physiology, Karolinska University Hospital, Stockholm, SE 17176, Sweden.; Department of Clinical Physiology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, SE 41345, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE 41345, Sweden.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2020 Aug 14; Vol. 15, pp. 6137-6152. Date of Electronic Publication: 2020 Aug 14 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Radioisotopes*/chemistry
Radioisotopes*/pharmacokinetics
Zirconium*/chemistry
Zirconium*/pharmacokinetics
Atherosclerosis/*diagnostic imaging
Maleates/*chemistry
Molecular Imaging/*methods
Serum Albumin, Human/*chemistry
Animals ; Aorta/diagnostic imaging ; Aorta/pathology ; Atherosclerosis/pathology ; Autoradiography ; Disease Models, Animal ; Female ; Fluorodeoxyglucose F18 ; Humans ; Isotope Labeling ; Macrophages/pathology ; Magnetic Resonance Imaging ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; Molecular Probes/chemistry ; Molecular Probes/pharmacokinetics ; Plaque, Atherosclerotic/diagnostic imaging ; Plaque, Atherosclerotic/pathology ; Positron-Emission Tomography ; Radiopharmaceuticals/chemistry ; Tissue Distribution
Czasopismo naukowe
Tytuł :
A New Drug-Drug Interaction Between Hydroxychloroquine and Metformin? A Signal Detection Study.
Autorzy :
Montastruc JL; Service de Pharmacologie Médicale et Clinique, Centre de PharmacoVigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, Faculté de Médecine, Centre Hospitalier Universitaire, 37 allées Jules-Guesde, 31000, Toulouse, France. .
Toutain PL; INTHERES, Université de Toulouse, INRA, ENVT, Toulouse, France.; The Royal Veterinary College, University of London, London, UK.
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Źródło :
Drug safety [Drug Saf] 2020 Jul; Vol. 43 (7), pp. 657-660.
Typ publikacji :
Journal Article
MeSH Terms :
Coronavirus Infections*/diagnosis
Coronavirus Infections*/drug therapy
Coronavirus Infections*/epidemiology
Drug Interactions*
Drug Therapy, Combination*/adverse effects
Drug Therapy, Combination*/mortality
Hydroxychloroquine*/pharmacokinetics
Hydroxychloroquine*/therapeutic use
Metformin*/pharmacokinetics
Metformin*/therapeutic use
Pandemics*
Pneumonia, Viral*/diagnosis
Pneumonia, Viral*/drug therapy
Pneumonia, Viral*/epidemiology
Adult ; Adverse Drug Reaction Reporting Systems/statistics & numerical data ; Betacoronavirus/isolation & purification ; Female ; Humans ; Hypoglycemic Agents/pharmacokinetics ; Hypoglycemic Agents/therapeutic use ; Male ; Middle Aged ; Pharmacovigilance
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Dexamethasone Sodium Phosphate Penetration During Phonophoresis at 2 Ultrasound Frequencies.
Autorzy :
Rigby JH; University of Utah, Salt Lake City.
Hagan AM; Texas State University, San Marcos.
Kelcher AR; Texas State University, San Marcos.
Ji C; Texas State University, San Marcos.
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Źródło :
Journal of athletic training [J Athl Train] 2020 Jun 23; Vol. 55 (6), pp. 628-635.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Dexamethasone*/administration & dosage
Dexamethasone*/pharmacokinetics
Phonophoresis/*methods
Adult ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/pharmacokinetics ; Biological Availability ; Drug Monitoring/methods ; Glucocorticoids/administration & dosage ; Glucocorticoids/pharmacokinetics ; Healthy Volunteers ; Humans ; Male ; Outcome Assessment, Health Care ; Time Factors
Czasopismo naukowe
Tytuł :
Capillary microsampling in mice: effective way to move from sparse sampling to serial sampling in pharmacokinetics profiling.
Autorzy :
Raje AA; Drug Metabolism Pharmacokinetics and Clinical Pharmacology, Eurofins Advinus Ltd., (Formerly known as Advinus Therapeutics Ltd), Bengaluru, India.
Mahajan V; Drug Metabolism Pharmacokinetics and Clinical Pharmacology, Eurofins Advinus Ltd., (Formerly known as Advinus Therapeutics Ltd), Bengaluru, India.
Pathade VV; Drug Metabolism Pharmacokinetics and Clinical Pharmacology, Eurofins Advinus Ltd., (Formerly known as Advinus Therapeutics Ltd), Bengaluru, India.
Joshi K; Drug Metabolism Pharmacokinetics and Clinical Pharmacology, Eurofins Advinus Ltd., (Formerly known as Advinus Therapeutics Ltd), Bengaluru, India.
Gavali A; Drug Metabolism Pharmacokinetics and Clinical Pharmacology, Eurofins Advinus Ltd., (Formerly known as Advinus Therapeutics Ltd), Bengaluru, India.
Gaur A; Drug Metabolism Pharmacokinetics and Clinical Pharmacology, Eurofins Advinus Ltd., (Formerly known as Advinus Therapeutics Ltd), Bengaluru, India.
Kandikere V; Drug Metabolism Pharmacokinetics and Clinical Pharmacology, Eurofins Advinus Ltd., (Formerly known as Advinus Therapeutics Ltd), Bengaluru, India.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Jun; Vol. 50 (6), pp. 663-669. Date of Electronic Publication: 2019 Oct 30.
Typ publikacji :
Journal Article
MeSH Terms :
Pharmacokinetics*
Blood Specimen Collection/*methods
Pharmaceutical Preparations/*blood
Animals ; Capillaries ; Drug Discovery ; Mice
Czasopismo naukowe
Tytuł :
Mechanisms of increased bioavailability through amorphous solid dispersions: a review.
Autorzy :
Schittny A; Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel, Switzerland.; Department of Biomedicine, Division of Clinical Pharmacology and Toxicology, University Hospital Basel and University of Basel, Basel, Switzerland.
Huwyler J; Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel, Switzerland.
Puchkov M; Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel, Switzerland.
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Źródło :
Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 110-127.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Pharmacokinetics*
Excipients/*chemistry
Technology, Pharmaceutical/*methods
Biological Availability ; Crystallization ; Delayed-Action Preparations ; Drug Liberation ; Drug Stability ; Solubility ; Surface-Active Agents/chemistry
Czasopismo naukowe
Tytuł :
Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug-drug interactions using physiologically based pharmacokinetic modelling approach.
Autorzy :
Iwasaki S; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.; b Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co. , Cambridge , MA , USA.
Kosugi Y; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Zhu AZX; b Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co. , Cambridge , MA , USA.
Nakagawa S; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Sano N; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Funami M; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Kosaka M; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Furuta A; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Hirabayashi H; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Amano N; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Nov; Vol. 49 (11), pp. 1251-1259. Date of Electronic Publication: 2019 Feb 03.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Drug Interactions*
Pharmacokinetics*
Cytochrome P-450 Enzyme System/*metabolism
Erythrocytes/*drug effects
Liver/*drug effects
Animals ; Area Under Curve ; Erythrocytes/metabolism ; Humans ; Itraconazole/pharmacokinetics ; Liver/metabolism ; Male ; Models, Biological ; Rats, Sprague-Dawley ; Software ; Triazolam/pharmacokinetics
Czasopismo naukowe
Tytuł :
Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19.
Autorzy :
Li R; Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China.
Wu K; Department of Pharmacy, The Second People's Hospital of Nanning City, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Li Y; Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China.
Liang X; Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China.
Tse WKF; Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Yang L; Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China.
Lai KP; Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China.
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Źródło :
Aging [Aging (Albany NY)] 2020 Aug 15; Vol. 12 (15), pp. 15784-15796. Date of Electronic Publication: 2020 Aug 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Betacoronavirus*/drug effects
Betacoronavirus*/genetics
Betacoronavirus*/physiology
Coronavirus Infections*/drug therapy
Coronavirus Infections*/epidemiology
Coronavirus Infections*/immunology
Inflammation*/drug therapy
Inflammation*/etiology
Inflammation*/immunology
Pandemics*
Pneumonia, Viral*/drug therapy
Pneumonia, Viral*/epidemiology
Pneumonia, Viral*/immunology
Vitamin A*/pharmacokinetics
Vitamin A*/therapeutic use
Immunity/*drug effects
Biological Availability ; Computational Biology/methods ; Gene Ontology ; Humans ; Signal Transduction/drug effects ; Vitamins/pharmacokinetics ; Vitamins/therapeutic use
SCR Disease Name :
COVID-19
Czasopismo naukowe

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