Temat: "Pharmacology" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Role of pharmacometrics and systems pharmacology in facilitating efficient dose optimization in oncology.
Autorzy:: Jayachandran P; Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Desikan R; Clinical Pharmacology Modeling & Simulation, GlaxoSmithKline (GSK), Stevenage, Hertfordshire, UK.
Krishnaswami S; Oncology Research and Development, Pfizer, Groton, Connecticut, USA.
Hennig S; Certara, Inc., Melbourne, Victoria, Australia.; School of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Źródło:: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 Nov; Vol. 12 (11), pp. 1569-1572. Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:: Editorial
MeSH Terms:: Pharmacology, Clinical*
Pharmacology*
Humans ; Network Pharmacology ; Medical Oncology

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Skocz do pozycji: 2.

Tytuł:: Prevention of neointimal hyperplasia after coronary artery bypass graft via local delivery of sirolimus and rosuvastatin: network pharmacology and in vivo validation.
Autorzy:: Ryu JY; Division of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Jang EH; Division of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Lee J; School of Mechanical Engineering, Yonsei University, Seoul, 03722, South Korea.; Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Kim JH; Division of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Youn YN; Division of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, 03722, South Korea. .
Źródło:: Journal of translational medicine [J Transl Med] 2024 Feb 16; Vol. 22 (1), pp. 166. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:: Journal Article
MeSH Terms:: Sirolimus*/pharmacology
Sirolimus*/therapeutic use
Drugs, Chinese Herbal*
Animals ; Rabbits ; Rosuvastatin Calcium/pharmacology ; Rosuvastatin Calcium/therapeutic use ; Hyperplasia/drug therapy ; Matrix Metalloproteinase 9 ; Network Pharmacology ; Proto-Oncogene Proteins c-akt ; Neointima ; Coronary Artery Bypass/adverse effects

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Skocz do pozycji: 3.

Tytuł:: Network Pharmacology and Experimental Verifications to Discover Scutellaria baicalensis Georgi's Effects on Joint Inflammation, Destruction, and Pain in Osteoarthritis.
Autorzy:: Jo HG; Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam-si 13120, Republic of Korea.; Naturalis Inc., 6 Daewangpangyo-ro, Bundang-gu, Seongnam-si 13549, Republic of Korea.
Baek CY; Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam-si 13120, Republic of Korea.
Song HS; Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam-si 13120, Republic of Korea.
Lee D; Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam-si 13120, Republic of Korea.
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 09; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Osteoarthritis*/drug therapy
Drugs, Chinese Herbal*/pharmacology
Network Pharmacology ; Scutellaria baicalensis ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Inflammation/drug therapy ; Pain/drug therapy ; Molecular Docking Simulation

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Skocz do pozycji: 4.

Tytuł:: Network pharmacology-based strategy to investigate the mechanisms of artemisinin in treating primary Sjögren's syndrome.
Autorzy:: Liao JH; Graduate School, Beijing University of Chinese Medicine, Beijing, China.; Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, China.
He Q; Graduate School, Beijing University of Chinese Medicine, Beijing, China.; Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Huang ZW; Graduate School, Beijing University of Chinese Medicine, Beijing, China.; Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Yu XB; Graduate School, Beijing University of Chinese Medicine, Beijing, China.; Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Yang JY; Graduate School, Beijing University of Chinese Medicine, Beijing, China.; Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Zhang Y; Graduate School, Beijing University of Chinese Medicine, Beijing, China.; Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Song WJ; Traditional Chinese Medicine Department, Peking University Third Hospital, Beijing, China.
Luo J; Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, China. .; Beijing Key Laboratory of Immune Inflammatory Disease, China-Japan Friendship Hospital, Beijing, China. .
Tao QW; Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, China. .; Beijing Key Laboratory of Immune Inflammatory Disease, China-Japan Friendship Hospital, Beijing, China. .
Źródło:: BMC immunology [BMC Immunol] 2024 Feb 12; Vol. 25 (1), pp. 16. Date of Electronic Publication: 2024 Feb 12.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Sjogren's Syndrome*/drug therapy
Artemisinins*/pharmacology
Artemisinins*/therapeutic use
Mice ; Animals ; Mice, Inbred NOD ; Interleukin-17 ; Molecular Docking Simulation ; Network Pharmacology ; Phosphatidylinositol 3-Kinases

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Skocz do pozycji: 5.

Tytuł:: Cytotoxic metabolites from Sinularia levi supported by network pharmacology.
Autorzy:: Sun M; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Abdelwahab MF; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt.
Zhang J; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Samy MN; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt.
Mohamed NM; Department of Pharmaceutical Chemistry, Modern University for Technology and Information (MTI), Cairo, Egypt.
Abdel-Rahman IM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New-Minia, Minia, Egypt.
Alsenani F; Department of Pharmacognosy, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Abdelmohsen UR; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, New Minia, Egypt.
Mahmoud BK; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt.
Źródło:: PloS one [PLoS One] 2024 Feb 06; Vol. 19 (2), pp. e0294311. Date of Electronic Publication: 2024 Feb 06 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Network Pharmacology*
Antineoplastic Agents*/pharmacology
Humans ; Caco-2 Cells ; Molecular Docking Simulation ; Plant Extracts/pharmacology ; Steroids

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Skocz do pozycji: 6.

Tytuł:: Exploration in the Mechanism of Ginsenoside Rg5 for the Treatment of Osteosarcoma by Network Pharmacology and Molecular Docking.
Autorzy:: Liu MY; Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
Jiang DX; Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
Zhao X; Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
Zhang L; Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
Zhang Y; Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
Liu ZD; Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
Liu RZ; Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
Li HJ; Department of Immunity, Institute of Translational Medicine, The First Hospital of Jilin University, Jilin, China.
Rong XY; Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
Gao YZ; Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
Źródło:: Orthopaedic surgery [Orthop Surg] 2024 Feb; Vol. 16 (2), pp. 462-470. Date of Electronic Publication: 2023 Dec 12.
Typ publikacji:: Journal Article
MeSH Terms:: Ginsenosides*/pharmacology
Ginsenosides*/therapeutic use
Osteosarcoma*/drug therapy
Bone Neoplasms*/drug therapy
Drugs, Chinese Herbal*
Humans ; Molecular Docking Simulation ; Network Pharmacology ; Phosphatidylinositol 3-Kinases

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Skocz do pozycji: 7.

Tytuł:: Exploration of hypoglycemic peptides from porcine collagen based on network pharmacology and molecular docking.
Autorzy:: Zhou F; College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, China.
Li D; College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, China.
Hou Y; College of Food Science and Technology, Hebei Agricultural University, Baoding, China.
Cong Z; College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, China.
Li K; College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, China.
Gu X; College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, China.
Xiao G; College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, China.
Źródło:: PloS one [PLoS One] 2024 Mar 12; Vol. 19 (3), pp. e0298674. Date of Electronic Publication: 2024 Mar 12 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Hypoglycemic Agents*/pharmacology
Diabetes Mellitus, Type 2*
Swine ; Animals ; Molecular Docking Simulation ; alpha-Glucosidases/metabolism ; Network Pharmacology ; Peptides/chemistry

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Skocz do pozycji: 8.

Tytuł:: A Chinese herbal formula Kesuting Syrup against COVID-19: Leveraging multidimensional computations in network pharmacology-driven experimental and clinical trials.
Autorzy:: Zhang C; School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.
Sun TT; National-Local Joint Engineering Research Center for Modern Miao Herbs Innovation Technology, Anshun, China.
Lv Y; Shanghai Public Health Clinical Center, Shanghai, China.
Li X; National-Local Joint Engineering Research Center for Modern Miao Herbs Innovation Technology, Anshun, China.
Ling Y; Shanghai Public Health Clinical Center, Shanghai, China.
Wang N; School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.
Xia W; National-Local Joint Engineering Research Center for Modern Miao Herbs Innovation Technology, Anshun, China.
Fan X; Shanghai Public Health Clinical Center, Shanghai, China.
Feng Y; School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.
Źródło:: Clinical and translational medicine [Clin Transl Med] 2024 Feb; Vol. 14 (2), pp. e1569.
Typ publikacji:: Letter; Research Support, Non-U.S. Gov't
MeSH Terms:: COVID-19*
Drugs, Chinese Herbal*/pharmacology
Drugs, Chinese Herbal*/therapeutic use
Humans ; Network Pharmacology ; Medicine, Chinese Traditional

Raport

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Skocz do pozycji: 9.

Tytuł:: Solid-Phase Microextraction/Gas Chromatography-Time-of-Flight Mass Spectrometry Approach Combined with Network Pharmacology Analysis to Evaluate the Quality of Agarwood from Different Regions against Anxiety Disorder.
Autorzy:: Pang Y; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.; Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China.
Yu W; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China.
Liang W; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.; Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China.
Gao Y; Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China.
Yang F; Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China.
Zhu Y; Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China.
Feng L; Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China.
Yin H; Hangzhou Institute for Food and Drug Control, Hangzhou 310022, China.
Liu Y; Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China.
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Jan 17; Vol. 29 (2). Date of Electronic Publication: 2024 Jan 17.
Typ publikacji:: Journal Article
MeSH Terms:: Anti-Anxiety Agents*/pharmacology
Sesquiterpenes*/pharmacology
Humans ; Network Pharmacology ; Solid Phase Microextraction ; Anxiety Disorders ; Gas Chromatography-Mass Spectrometry

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Skocz do pozycji: 10.

Tytuł:: Study of the Mechanism of Astragali Radix in Treating Type 2 Diabetes Mellitus and Its Renal Protection Based on Enzyme Activity, Network Pharmacology, and Experimental Verification.
Autorzy:: Li C; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.; Jilin Correction Pharmacy New Drug Development Co., Ltd., Changchun 130012, China.
Zhang K; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Liu L; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Shen J; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Wang Y; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Tan Y; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Feng X; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Liu W; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Zhang H; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Sun J; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Dec 10; Vol. 28 (24). Date of Electronic Publication: 2023 Dec 10.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus, Type 2*/drug therapy
Astragalus Plant*
Drugs, Chinese Herbal*/pharmacology
Animals ; Mice ; Molecular Docking Simulation ; Network Pharmacology ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; alpha-Glucosidases ; Kidney ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use

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Skocz do pozycji: 11.

Tytuł:: Integrating network pharmacology and animal experimental validation to investigate the action mechanism of oleanolic acid in obesity.
Autorzy:: Liu T; School of Chinese Materia Medica, Guangdong Pharmaceutical University, Waihuan East Road, Guangzhou, 510006, Guangdong, China.
Wang J; School of Chinese Materia Medica, Guangdong Pharmaceutical University, Waihuan East Road, Guangzhou, 510006, Guangdong, China.
Tong Y; School of Chinese Materia Medica, Guangdong Pharmaceutical University, Waihuan East Road, Guangzhou, 510006, Guangdong, China.
Wu L; School of Chinese Materia Medica, Guangdong Pharmaceutical University, Waihuan East Road, Guangzhou, 510006, Guangdong, China.
Xie Y; School of Chinese Materia Medica, Guangdong Pharmaceutical University, Waihuan East Road, Guangzhou, 510006, Guangdong, China.
He P; School of Chinese Materia Medica, Guangdong Pharmaceutical University, Waihuan East Road, Guangzhou, 510006, Guangdong, China.
Lin S; School of Chinese Materia Medica, Guangdong Pharmaceutical University, Waihuan East Road, Guangzhou, 510006, Guangdong, China.
Hu X; School of Chinese Materia Medica, Guangdong Pharmaceutical University, Waihuan East Road, Guangzhou, 510006, Guangdong, China. .
Źródło:: Journal of translational medicine [J Transl Med] 2024 Jan 21; Vol. 22 (1), pp. 86. Date of Electronic Publication: 2024 Jan 21.
Typ publikacji:: Journal Article
MeSH Terms:: Oleanolic Acid*/pharmacology
Oleanolic Acid*/therapeutic use
Cardiovascular Diseases*
Animals ; Molecular Docking Simulation ; Network Pharmacology ; PPAR gamma

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Skocz do pozycji: 12.

Tytuł:: Uncovering the Anti-Angiogenic Mechanisms of Centella asiatica via Network Pharmacology and Experimental Validation.
Autorzy:: Zhao B; Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Li Y; Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Wang B; Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Liu J; Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Yang Y; Yunnan Baiyao Group Shanghai Science & Technology Co., Ltd., Shanghai 201100, China.; East Asia Skin Health Research Center, Beijing 100037, China.
Quan Q; Yunnan Baiyao Group Shanghai Science & Technology Co., Ltd., Shanghai 201100, China.; East Asia Skin Health Research Center, Beijing 100037, China.
An Q; Yunnan Baiyao Group Shanghai Science & Technology Co., Ltd., Shanghai 201100, China.; East Asia Skin Health Research Center, Beijing 100037, China.
Liang R; Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Liu C; Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Yang C; Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Jan 11; Vol. 29 (2). Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:: Journal Article
MeSH Terms:: Centella*
Triterpenes*/pharmacology
Neoplasms*
Humans ; Network Pharmacology ; Molecular Docking Simulation ; Prospective Studies ; Human Umbilical Vein Endothelial Cells

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Skocz do pozycji: 13.

Tytuł:: The mechanisms of Huangqi Guizhi Wuwu decoction in treating ischaemic stroke based on network pharmacology and experiment verification.
Autorzy:: Liao W; College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Wang M; College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Wu Y; College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Du J; College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Li Y; College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Su A; College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Zhong L; College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Xie Z; College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Gong M; College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Liang J; College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Wang P; College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Liu Z; Pharmacy Department, Dongguan Hospital of Traditional Chinese Medicine, Dongguan, Guangdong, China.
Wang L; College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Źródło:: Pharmaceutical biology [Pharm Biol] 2023 Dec; Vol. 61 (1), pp. 1014-1029.
Typ publikacji:: Journal Article
MeSH Terms:: Brain Ischemia*/drug therapy
Neuroprotective Agents*/pharmacology
Stroke*/drug therapy
Ischemic Stroke*/drug therapy
Drugs, Chinese Herbal*/pharmacology
Drugs, Chinese Herbal*/therapeutic use
Animals ; Rats ; Rats, Sprague-Dawley ; Network Pharmacology ; Molecular Docking Simulation ; Phosphatidylinositol 3-Kinases ; Cytokines

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Skocz do pozycji: 14.

Tytuł:: Forecast and verification of the active compounds and latent targets of Guyuan decoction in treating frequently relapsing nephrotic syndrome based on network pharmacology.
Autorzy:: Wang H; Traditional Chinese Medicine Pediatrics Department, Second Outpatient Department, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Shi J; Clinical School of Medicine, Hangzhou Medical College, Hangzhou, China.
Tang B; Internal Medicine of Traditional Chinese Medicine Department, Second Outpatient Department, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Liu Y; Traditional Chinese Medicine Department, Jinan Maternal and Child Health Hospital Shunyu Road Community Health Service Center, Jinan, China.
Wang Q; Pediatrics Department, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.
Źródło:: Renal failure [Ren Fail] 2023 Dec; Vol. 45 (1), pp. 2184654.
Typ publikacji:: Journal Article
MeSH Terms:: Nephrotic Syndrome*/drug therapy
Network Pharmacology*
Caspase 3 ; Doxorubicin/pharmacology ; Luteolin ; Molecular Docking Simulation ; Animals ; Mice ; Cell Line

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Skocz do pozycji: 15.

Tytuł:: A Network Pharmacology Prediction and Molecular Docking-Based Strategy to Explore the Potential Pharmacological Mechanism of Astragalus membranaceus for Glioma.
Autorzy:: Feng Y; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen Campus, Shenzhen 518107, China.; Computer Aided Drug Discovery Center, Zhuhai Institute of Advanced Technology, Chinese Academy of Sciences, Zhuhai 519003, China.
Zhu P; Computer Aided Drug Discovery Center, Zhuhai Institute of Advanced Technology, Chinese Academy of Sciences, Zhuhai 519003, China.
Wu D; Computer Aided Drug Discovery Center, Zhuhai Institute of Advanced Technology, Chinese Academy of Sciences, Zhuhai 519003, China.
Deng W; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen Campus, Shenzhen 518107, China.
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 14; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 14.
Typ publikacji:: Journal Article
MeSH Terms:: Glioma*/drug therapy
Drugs, Chinese Herbal*/pharmacology
Astragalus propinquus ; Molecular Docking Simulation ; Network Pharmacology ; Cyclooxygenase 2 ; Medicine, Chinese Traditional

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Skocz do pozycji: 16.

Tytuł:: Network Pharmacology Combined with Machine Learning to Reveal the Action Mechanism of Licochalcone Intervention in Liver Cancer.
Autorzy:: Guo F; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Yang X; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Hu C; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Li W; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Han W; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 03; Vol. 24 (21). Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:: Journal Article
MeSH Terms:: Chalcones*/pharmacology
Chalcones*/chemistry
Liver Neoplasms*/drug therapy
Humans ; Network Pharmacology ; Flavonoids ; NF-kappa B

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Skocz do pozycji: 17.

Tytuł:: Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics.
Autorzy:: Zeng L; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Graduate School of Peking Union Medical College, Nanjing, China.
Yu G; People's Hospital of Ningxiang City, Ningxiang, China.
Yang K; Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China.
He Q; Department of Rehabilitation Medicine, Guangzhou Panyu Central Hospital, Guangzhou, China.
Hao W; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xiang W; Department of Rheumatology, The First People's Hospital Changde City, Changde, China.
Long Z; Department of Rehabilitation Medicine, Guangzhou Panyu Central Hospital, Guangzhou, China.
Chen H; Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China.
Tang X; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Graduate School of Peking Union Medical College, Nanjing, China. .
Sun L; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Graduate School of Peking Union Medical College, Nanjing, China. .; Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Anhui, China. .
Źródło:: Scientific reports [Sci Rep] 2024 Jan 18; Vol. 14 (1), pp. 1604. Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:: Journal Article
MeSH Terms:: Triterpenes*/pharmacology
Triterpenes*/therapeutic use
Arthritis, Rheumatoid*/drug therapy
Arthritis, Rheumatoid*/genetics
Pentacyclic Triterpenes*
Mice ; Animals ; Network Pharmacology ; Molecular Docking Simulation ; Multiomics ; Proteomics ; Phosphatidylinositol 3-Kinases

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Skocz do pozycji: 18.

Tytuł:: Network pharmacology-based research on the effect of Radix Astragali on osteosarcoma and the underlying mechanism.
Autorzy:: Zhang Y; Department of Traumatology and Orthopaedics, Affiliated Hospital of Chengde Medical University, Chengde, 067000, Hebei, China.
Wei J; Department of Traumatology and Orthopaedics, Affiliated Hospital of Chengde Medical University, Chengde, 067000, Hebei, China.
Kong L; Department of Traumatology and Orthopaedics, Affiliated Hospital of Chengde Medical University, Chengde, 067000, Hebei, China.
Song M; Department of Traumatology and Orthopaedics, Affiliated Hospital of Chengde Medical University, Chengde, 067000, Hebei, China.
Zhang Y; Department of Traumatology and Orthopaedics, Affiliated Hospital of Chengde Medical University, Chengde, 067000, Hebei, China.
Xiao X; Department of Traumatology and Orthopaedics, Affiliated Hospital of Chengde Medical University, Chengde, 067000, Hebei, China.
Cao H; Department of Traumatology and Orthopaedics, Affiliated Hospital of Chengde Medical University, Chengde, 067000, Hebei, China.
Jin Y; Department of Traumatology and Orthopaedics, Affiliated Hospital of Chengde Medical University, Chengde, 067000, Hebei, China. .
Źródło:: Scientific reports [Sci Rep] 2023 Dec 15; Vol. 13 (1), pp. 22315. Date of Electronic Publication: 2023 Dec 15.
Typ publikacji:: Journal Article
MeSH Terms:: Osteosarcoma*/drug therapy
Sarcoma*
Drugs, Chinese Herbal*/pharmacology
Drugs, Chinese Herbal*/therapeutic use
Soft Tissue Neoplasms*
Bone Neoplasms*/drug therapy
Humans ; Molecular Docking Simulation ; Network Pharmacology
SCR Organism:: Hygrophila, gastropods

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Skocz do pozycji: 19.

Tytuł:: Discovering Potential Compounds for Venous Disease Treatment through Virtual Screening and Network Pharmacology Approach.
Autorzy:: Barrera-Vázquez OS; Department of Pharmacology, Faculty of Medicine, University National Autonomous of Mexico (UNAM), Mexico City 04510, Mexico.
Escobar-Ramírez JL; Department of Pharmacology, Faculty of Medicine, University National Autonomous of Mexico (UNAM), Mexico City 04510, Mexico.
Santiago-Mejía J; Department of Pharmacology, Faculty of Medicine, University National Autonomous of Mexico (UNAM), Mexico City 04510, Mexico.
Carrasco-Ortega OF; Department of Pharmacology, Faculty of Medicine, University National Autonomous of Mexico (UNAM), Mexico City 04510, Mexico.
Magos-Guerrero GA; Department of Pharmacology, Faculty of Medicine, University National Autonomous of Mexico (UNAM), Mexico City 04510, Mexico.
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Dec 05; Vol. 28 (24). Date of Electronic Publication: 2023 Dec 05.
Typ publikacji:: Journal Article
MeSH Terms:: Hypertension*/drug therapy
Drugs, Chinese Herbal*/pharmacology
Humans ; Network Pharmacology ; Quality of Life ; Signal Transduction ; Edema/drug therapy ; Molecular Docking Simulation

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Skocz do pozycji: 20.

Tytuł:: Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy.
Autorzy:: Yu B; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.; Key Laboratory of Chinese Internal Medicine of Ministry of Education, Beijing Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.
Zhou M; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.; Key Laboratory of Chinese Internal Medicine of Ministry of Education, Beijing Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.
Dong Z; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.; Key Laboratory of Chinese Internal Medicine of Ministry of Education, Beijing Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.
Zheng H; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.; Key Laboratory of Chinese Internal Medicine of Ministry of Education, Beijing Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.
Zhao Y; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.; Key Laboratory of Chinese Internal Medicine of Ministry of Education, Beijing Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.; Beijing Dongcheng First People's Hospital, Beijing, P.R. China.
Zhou J; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.
Zhang C; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.; Key Laboratory of Chinese Internal Medicine of Ministry of Education, Beijing Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.
Wei F; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.; Key Laboratory of Chinese Internal Medicine of Ministry of Education, Beijing Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.
Yu G; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.
Liu WJ; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.; Key Laboratory of Chinese Internal Medicine of Ministry of Education, Beijing Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.
Liu H; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, P.R. China.
Wang Y; Beijing University of Chinese Medicine, Beijing, P.R. China.
Źródło:: Pharmaceutical biology [Pharm Biol] 2023 Dec; Vol. 61 (1), pp. 1222-1233.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetic Nephropathies*/metabolism
Diabetes Mellitus, Experimental*/complications
Diabetes Mellitus, Experimental*/drug therapy
Diabetes Mellitus, Experimental*/metabolism
Drugs, Chinese Herbal*/pharmacology
Drugs, Chinese Herbal*/therapeutic use
Rats ; Male ; Humans ; Animals ; Network Pharmacology ; Rats, Sprague-Dawley ; Glycation End Products, Advanced/metabolism

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