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Tytuł:
Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics.
Autorzy:
Fernández DI; The Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands.; Platelet Proteomics Group, CiMUS, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Troitiño S; Platelet Proteomics Group, CiMUS, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Sobota V; IHU-LIRYC, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, 33604, Bordeaux, France.; Institut de Mathématiques de Bordeaux, UMR5251, University of Bordeaux, 33 405, Talence, France.
Tullemans BME; The Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands.; Synapse Research Institute, Kon. Emmaplein 7, 6217 KD, Maastricht, The Netherlands.
Zou J; The Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands.; Synapse Research Institute, Kon. Emmaplein 7, 6217 KD, Maastricht, The Netherlands.
van den Hurk H; Pivot Park Screening Centre, 5349 AB, Oss, The Netherlands.
García Á; Platelet Proteomics Group, CiMUS, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Honarnejad S; Pivot Park Screening Centre, 5349 AB, Oss, The Netherlands.
Kuijpers MJE; The Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands. .; Thrombosis Expertise Centre, Heart and Vascular Centre, Maastricht University Medical Centre+, 6229 HX, Maastricht, The Netherlands. .
Heemskerk JWM; The Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands. .; Synapse Research Institute, Kon. Emmaplein 7, 6217 KD, Maastricht, The Netherlands. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 14; Vol. 14 (1), pp. 6229. Date of Electronic Publication: 2024 Mar 14.
Typ publikacji:
Journal Article
MeSH Terms:
Platelet Aggregation Inhibitors*/pharmacology
Calcium*/metabolism
Phenothiazines*
Humans ; Thrombin/metabolism ; Calcium Signaling ; Platelet Membrane Glycoproteins/metabolism ; Receptor, PAR-1/metabolism ; Blood Platelets/metabolism ; Platelet Activation ; Calcium, Dietary/pharmacology ; Platelet Aggregation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and Spectroscopic Characterization of Selected Phenothiazines and Phenazines Rationalized Based on DFT Calculation.
Autorzy:
Swoboda D; Institute of Chemistry, Faculty of Science and Technology, University of Silesia in Katowice, ul. Szkolna 9, 40-007 Katowice, Poland.
Nycz JE; Institute of Chemistry, Faculty of Science and Technology, University of Silesia in Katowice, ul. Szkolna 9, 40-007 Katowice, Poland.
Karaush-Karmazin N; Department of Chemistry and Nanomaterials Science, Bohdan Khmelnytsky National University, 18031 Cherkasy, Ukraine.
Minaev B; Department of Chemistry and Nanomaterials Science, Bohdan Khmelnytsky National University, 18031 Cherkasy, Ukraine.
Książek M; Institute of Physics, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.
Kusz J; Institute of Physics, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.
Podsiadły R; Institute of Polymer and Dye Technology, Faculty of Chemistry, Lodz University of Technology, Stefanowskiego 12/16, 90-924 Lodz, Poland.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Nov 04; Vol. 27 (21). Date of Electronic Publication: 2022 Nov 04.
Typ publikacji:
Journal Article
MeSH Terms:
Phenothiazines*/chemistry
Phenazines*
Density Functional Theory ; Magnetic Resonance Spectroscopy ; Oxides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII.
Autorzy:
Fiorentino F; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.
Nocentini A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Polo Scientifico, University of Florence, Firenze, Italy.
Rotili D; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.
Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Polo Scientifico, University of Florence, Firenze, Italy.
Mai A; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.; Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, Rome, Italy.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2188147.
Typ publikacji:
Journal Article
MeSH Terms:
Antipsychotic Agents*/pharmacology
Carbonic Anhydrases*/metabolism
Humans ; Antidepressive Agents, Tricyclic/pharmacology ; Protein Isoforms/metabolism ; Phenothiazines ; Histamine Antagonists/pharmacology ; Carbonic Anhydrase Inhibitors/pharmacology ; Structure-Activity Relationship ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Development of Phenothiazine Hybrids with Potential Medicinal Interest: A Review.
Autorzy:
Posso MC; CICS-UBI-Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal.
Domingues FC; CICS-UBI-Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal.
Ferreira S; CICS-UBI-Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal.
Silvestre S; CICS-UBI-Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jan 03; Vol. 27 (1). Date of Electronic Publication: 2022 Jan 03.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Drug Development*
Phenothiazines*/chemical synthesis
Phenothiazines*/chemistry
Phenothiazines*/therapeutic use
Animals ; Humans ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Phenothiazines Inhibit SARS-CoV-2 Entry through Targeting Spike Protein.
Autorzy:
Liang T; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 511400, China.
Xiao S; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.
Wu Z; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Lv X; School of Medicine, South China University of Technology, Guangzhou 510006, China.
Liu S; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Hu M; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 511400, China.
Li G; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.
Li P; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.
Ma X; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 511400, China.; Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
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Źródło:
Viruses [Viruses] 2023 Jul 31; Vol. 15 (8). Date of Electronic Publication: 2023 Jul 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
SARS-CoV-2*
COVID-19*
Humans ; Phenothiazines/pharmacology ; Spike Glycoprotein, Coronavirus
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Lysozyme Inhibitor Thionine Acetate Is Also an Inhibitor of the Soluble Lytic Transglycosylase Slt35 from Escherichia coli .
Autorzy:
Mezoughi AB; School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, UK.
Costanzo CM; Department of Chemistry, Swansea University, Singleton Park, Swansea SA2 8PP, UK.
Parker GM; School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, UK.
Behiry EM; School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, UK.
Scott A; School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, UK.
Wood AC; School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, UK.
Adams SE; School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, UK.
Sessions RB; School of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, UK.
Loveridge EJ; School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, UK.; Department of Chemistry, Swansea University, Singleton Park, Swansea SA2 8PP, UK.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 09; Vol. 26 (14). Date of Electronic Publication: 2021 Jul 09.
Typ publikacji:
Journal Article
MeSH Terms:
Glycosyltransferases/*metabolism
Phenothiazines/*pharmacology
Acetates/metabolism ; Amino Acid Sequence/genetics ; Bacterial Proteins/chemistry ; Binding Sites/genetics ; Catalytic Domain/genetics ; Cell Wall/metabolism ; Crystallography, X-Ray/methods ; Escherichia coli/metabolism ; Escherichia coli Proteins/drug effects ; Escherichia coli Proteins/metabolism ; Glycosyltransferases/antagonists & inhibitors ; Glycosyltransferases/drug effects ; Models, Molecular ; Molecular Docking Simulation ; Muramidase/antagonists & inhibitors ; Muramidase/metabolism ; Peptidoglycan/metabolism ; Phenothiazines/metabolism ; Protein Conformation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antitumor Activity of PEGylated and TEGylated Phenothiazine Derivatives: Structure-Activity Relationship.
Autorzy:
Cibotaru S; 'Petru Poni' Institute of Macromolecular Chemistry, 700487 Iasi, Romania.
Sandu AI; 'Petru Poni' Institute of Macromolecular Chemistry, 700487 Iasi, Romania.
Nicolescu A; 'Petru Poni' Institute of Macromolecular Chemistry, 700487 Iasi, Romania.
Marin L; 'Petru Poni' Institute of Macromolecular Chemistry, 700487 Iasi, Romania.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 13; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 13.
Typ publikacji:
Journal Article
MeSH Terms:
Antipsychotic Agents*/pharmacology
Neoplasms*
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Humans ; Animals ; Mice ; Structure-Activity Relationship ; Phenothiazines/pharmacology ; Phenothiazines/chemistry ; Farnesyltranstransferase ; Cell Proliferation ; Polyethylene Glycols/pharmacology ; Drug Screening Assays, Antitumor ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Manipulating the Subcellular Localization and Anticancer Effects of Benzophenothiaziniums by Minor Alterations of N-Alkylation.
Autorzy:
Wu Y; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Chen Y; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.; Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.
Yao S; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Li S; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Yuan H; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Qi F; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
He W; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Guo Z; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.; Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 10; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 10.
Typ publikacji:
Journal Article
MeSH Terms:
Photosensitizing Agents*/pharmacology
Photochemotherapy*/methods
Humans ; Animals ; Mice ; Phenothiazines ; Alkylation ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Thionine-mediated electrocatalytic reduction for electrochemical detection of EDTA-Fe(III) in soy sauce.
Autorzy:
Su X; College of Life Sciences, Yantai University, Yantai, 264005, Shandong, China.
Meng X; College of Life Sciences, Yantai University, Yantai, 264005, Shandong, China.
Zhang Z; College of Life Sciences, Yantai University, Yantai, 264005, Shandong, China. .
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2023 Feb; Vol. 415 (4), pp. 639-648. Date of Electronic Publication: 2022 Nov 25.
Typ publikacji:
Journal Article
MeSH Terms:
Ferric Compounds*
Soy Foods*
Edetic Acid ; Phenothiazines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis, In Silico and In Vitro Evaluation for Acetylcholinesterase and BACE-1 Inhibitory Activity of Some N -Substituted-4-Phenothiazine-Chalcones.
Autorzy:
Tran TS; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, College of Medicine and Pharmacy, Hue University, Hue City 530000, Vietnam.
Le MT; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam.; School of Medicine, Vietnam National University Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam.
Nguyen TC; Faculty of Applied Sciences, Ton Duc Thang University, Nguyen Huu Tho St., Tan Phong Ward, Dist. 7, Ho Chi Minh City 70000, Vietnam.
Tran TH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, College of Medicine and Pharmacy, Hue University, Hue City 530000, Vietnam.
Tran TD; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam.
Thai KM; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 Aug 27; Vol. 25 (17). Date of Electronic Publication: 2020 Aug 27.
Typ publikacji:
Journal Article
MeSH Terms:
Chalcones*/chemical synthesis
Chalcones*/pharmacology
Cholinesterase Inhibitors*/chemical synthesis
Cholinesterase Inhibitors*/pharmacology
Phenothiazines*/chemical synthesis
Phenothiazines*/pharmacology
Molecular Docking Simulation ; Quantitative Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
10 H -1,9-diazaphenothiazine and its 10-derivatives: synthesis, characterisation and biological evaluation as potential anticancer agents.
Autorzy:
Morak-Młodawska B; a Department of Organic Chemistry, School of Pharmacy with the Division of Laboratory Medicine , The Medical University of Silesia , Sosnowiec , Poland.
Pluta K; a Department of Organic Chemistry, School of Pharmacy with the Division of Laboratory Medicine , The Medical University of Silesia , Sosnowiec , Poland.
Latocha M; b Department of Cell Biology, School of Pharmacy with the Division of Laboratory Medicine , The Medical University of Silesia , Sosnowiec , Poland.
Jeleń M; a Department of Organic Chemistry, School of Pharmacy with the Division of Laboratory Medicine , The Medical University of Silesia , Sosnowiec , Poland.
Kuśmierz D; b Department of Cell Biology, School of Pharmacy with the Division of Laboratory Medicine , The Medical University of Silesia , Sosnowiec , Poland.
Suwińska K; c Faculty of Mathematics and Natural Sciences , Cardinal Stefan Wyszyński University , Warszawa , Poland.; d A. M. Butlerov Institute of Chemistry , Kazan Federal University , Kazan , Russia.
Shkurenko A; e Division of Physical Functional Materials Design, Discovery & Development Research Group (FMD3) , Sciences and Engineering Advanced Membranes & Porous Materials (AMPM), King Abdullah University of Science and Technology (KAU ST) , Thuwal , Kingdom of Saudi Arabia.
Czuba Z; f Department of Microbiology and Immunology , Medical University of Silesia in Katowice , Zabrze , Poland.
Jurzak M; b Department of Cell Biology, School of Pharmacy with the Division of Laboratory Medicine , The Medical University of Silesia , Sosnowiec , Poland.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 1298-1306.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Phenothiazines/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Phenothiazines/chemical synthesis ; Phenothiazines/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, Synthesis, and Structural Characterization of Novel Diazaphenothiazines with 1,2,3-Triazole Substituents as Promising Antiproliferative Agents.
Autorzy:
Morak-Młodawska B; Department of Organic Chemistry, Faculty of Pharmaceutical Sciences, The Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Pluta K; Department of Organic Chemistry, Faculty of Pharmaceutical Sciences, The Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Latocha M; Department of Cell Biology, Faculty of Pharmaceutical Sciences, The Medical University of Silesia, Jedności 8, 41-200 Sosnowiec, Poland.
Jeleń M; Department of Organic Chemistry, Faculty of Pharmaceutical Sciences, The Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Kuśmierz D; Department of Cell Biology, Faculty of Pharmaceutical Sciences, The Medical University of Silesia, Jedności 8, 41-200 Sosnowiec, Poland.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 Nov 30; Vol. 24 (23). Date of Electronic Publication: 2019 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
Chemistry Techniques, Synthetic*
Drug Design*
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Phenothiazines/*chemistry
Phenothiazines/*pharmacology
Triazoles/*chemistry
Antineoplastic Agents/chemical synthesis ; Apoptosis/drug effects ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Phenothiazines/chemical synthesis ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An Inhibitor of the Interaction of Survivin with Smac in Mitochondria Promotes Apoptosis.
Autorzy:
Park SH; Department of Chemistry, Yonsei University, Seoul 03722, Korea.
Shin I; Department of Chemistry, Yonsei University, Seoul 03722, Korea.
Park SH; Department of Chemistry, Yonsei University, Seoul 03722, Korea.
Kim ND; NDBio Therapeutics Inc., Incheon, 21984, Korea.
Shin I; Department of Chemistry, Yonsei University, Seoul 03722, Korea.
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Źródło:
Chemistry, an Asian journal [Chem Asian J] 2019 Nov 18; Vol. 14 (22), pp. 4035-4041. Date of Electronic Publication: 2019 Jul 24.
Typ publikacji:
Journal Article
MeSH Terms:
Mitochondria/*metabolism
Oligopeptides/*metabolism
Phenothiazines/*chemistry
Survivin/*metabolism
Apoptosis/drug effects ; Binding Sites ; Cell Line, Tumor ; Cytochromes c/metabolism ; Humans ; Molecular Docking Simulation ; Oligopeptides/chemistry ; Phenothiazines/metabolism ; Phenothiazines/pharmacology ; Protein Interaction Domains and Motifs/drug effects ; Structure-Activity Relationship ; Survivin/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antioxidative Properties of Melanins and Ommochromes from Black Soldier Fly Hermetia illucens .
Autorzy:
Ushakova N; A.N. Severtsov Institute of Ecology and Evolution of Russian Academy of Sciences, 119071 Moscow, Russia. .
Dontsov A; N.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, 119334 Moscow, Russia.
Sakina N; N.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, 119334 Moscow, Russia.
Bastrakov A; A.N. Severtsov Institute of Ecology and Evolution of Russian Academy of Sciences, 119071 Moscow, Russia.
Ostrovsky M; N.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, 119334 Moscow, Russia.
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Źródło:
Biomolecules [Biomolecules] 2019 Aug 23; Vol. 9 (9). Date of Electronic Publication: 2019 Aug 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antioxidants/*chemistry
Melanins/*chemistry
Phenothiazines/*chemistry
Simuliidae/*metabolism
Adsorption ; Animals ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Electron Spin Resonance Spectroscopy ; Hydrogen Peroxide/chemistry ; Light ; Lipid Peroxidation/drug effects ; Lipid Peroxidation/radiation effects ; Melanins/isolation & purification ; Melanins/pharmacology ; Phenothiazines/isolation & purification ; Phenothiazines/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of Auxiliary Donors on 3,8-Phenothiazine Dyes for Dye-Sensitized Solar Cells.
Autorzy:
Buene AF; Department of Chemistry, Norwegian University of Science and Technology, Høgskoleringen 5, NO-7491 Trondheim, Norway.
Christensen M; Department of Chemistry, Norwegian University of Science and Technology, Høgskoleringen 5, NO-7491 Trondheim, Norway.
Hoff BH; Department of Chemistry, Norwegian University of Science and Technology, Høgskoleringen 5, NO-7491 Trondheim, Norway.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 Dec 07; Vol. 24 (24). Date of Electronic Publication: 2019 Dec 07.
Typ publikacji:
Journal Article
MeSH Terms:
Solar Energy*
Chenodeoxycholic Acid/*chemistry
Coloring Agents/*chemistry
Phenothiazines/*chemistry
Chenodeoxycholic Acid/chemical synthesis ; Coloring Agents/chemical synthesis ; Electric Power Supplies ; Electrochemistry ; Oxidation-Reduction ; Phenothiazines/chemical synthesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma.
Autorzy:
Santofimia-Castaño P; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université, CEDEX, Marseille 13288, France.; Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, CEDEX, Marseille 13288, France.
Xia Y; Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China.
Peng L; Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, «Equipe Labellisée Ligue Contre le Cancer», Parc Scientifique et Technologique de Luminy, CEDEX, Marseille 13288, France.
Velázquez-Campoy A; Instituto de Biocomputación y Física de Sistemas Complejos, Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza 50009, Spain.; Aragon Institute for Health Research (IIS Aragon), Universidad de Zaragoza, Zaragoza 50009, Spain.; Centro de Investigación Biomédica en Red en el Área Temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid 28029, Spain.; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza 50009, Spain.; Fundacion ARAID, Government of Aragon, Universidad de Zaragoza, Zaragoza 50018, Spain.
Abián O; Instituto de Biocomputación y Física de Sistemas Complejos, Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza 50009, Spain.; Aragon Institute for Health Research (IIS Aragon), Universidad de Zaragoza, Zaragoza 50009, Spain.; Centro de Investigación Biomédica en Red en el Área Temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid 28029, Spain.; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza 50009, Spain.; Instituto Aragonés de Ciencias de la Salud (IACS), Universidad de Zaragoza, Zaragoza 50009, Spain.
Lan W; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université, CEDEX, Marseille 13288, France.; Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, CEDEX, Marseille 13288, France.
Lomberk G; Division of Research, Department of Surgery and the Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Urrutia R; Division of Research, Department of Surgery and the Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Rizzuti B; CNR-NANOTEC, Licryl-UOS Cosenza and CEMIF.Cal, Department of Physics, University of Calabria, Cosenza 87036, Italy.
Soubeyran P; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université, CEDEX, Marseille 13288, France.; Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, CEDEX, Marseille 13288, France.
Neira JL; Instituto de Biocomputación y Física de Sistemas Complejos, Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza 50009, Spain.; Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Edificio Torregaitán, Elche 03202, Alicante, Spain.
Iovanna J; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université, CEDEX, Marseille 13288, France.; Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, CEDEX, Marseille 13288, France.
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Źródło:
Cells [Cells] 2019 Nov 17; Vol. 8 (11). Date of Electronic Publication: 2019 Nov 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Adenocarcinoma/*drug therapy
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Neoplasm Proteins/*metabolism
Pancreatic Neoplasms/*drug therapy
Phenothiazines/*therapeutic use
Adenocarcinoma/metabolism ; Animals ; Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors ; Dose-Response Relationship, Drug ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Mice ; Neoplasm Proteins/antagonists & inhibitors ; Pancreatic Neoplasms/metabolism ; Phenothiazines/pharmacology ; Protein Transport/drug effects ; Xenograft Model Antitumor Assays ; Pancreatic Neoplasms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
N -carbonyl-substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress.
Autorzy:
Keynes RG; Neural Signalling Group, The Wolfson Institute for Biomedical Research, University College London, London, UK.
Karchevskaya A; Drug Discovery Group, The Wolfson Institute for Biomedical Research, University College London, London, UK.
Riddall D; Neural Signalling Group, The Wolfson Institute for Biomedical Research, University College London, London, UK.
Griffiths CH; Neural Signalling Group, The Wolfson Institute for Biomedical Research, University College London, London, UK.
Bellamy TC; Neural Signalling Group, The Wolfson Institute for Biomedical Research, University College London, London, UK.
Chan AWE; Drug Discovery Group, The Wolfson Institute for Biomedical Research, University College London, London, UK.
Selwood DL; Drug Discovery Group, The Wolfson Institute for Biomedical Research, University College London, London, UK.
Garthwaite J; Neural Signalling Group, The Wolfson Institute for Biomedical Research, University College London, London, UK.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2019 Sep; Vol. 94 (3), pp. 1680-1693. Date of Electronic Publication: 2019 Jun 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antipsychotic Agents/*chemistry
Neurodegenerative Diseases/*drug therapy
Phenothiazines/*chemistry
Protective Agents/*chemistry
Antipsychotic Agents/pharmacology ; Brain ; Chromans/pharmacology ; Drug Evaluation, Preclinical ; Humans ; Lipid Peroxidation/drug effects ; Models, Molecular ; Molecular Structure ; Nitric Oxide/metabolism ; Oxidation-Reduction ; Oxidative Stress/drug effects ; Phenothiazines/pharmacology ; Protective Agents/pharmacology ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship ; Vitamin E/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis, Anticancer Activity, and Apoptosis Induction of Novel 3,6-Diazaphenothiazines.
Autorzy:
Morak-Młodawska B; Department of Organic Chemistry, School of Pharmacy with the Division of Laboratory Medicine, The Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland. .
Pluta K; Department of Organic Chemistry, School of Pharmacy with the Division of Laboratory Medicine, The Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland. .
Latocha M; Department of Cell Biology, School of Pharmacy with the Division of Laboratory Medicine, The Medical University of Silesia, Jedności 8, 41-200 Sosnowiec, Poland. .
Jeleń M; Department of Organic Chemistry, School of Pharmacy with the Division of Laboratory Medicine, The Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland. .
Kuśmierz D; Department of Cell Biology, School of Pharmacy with the Division of Laboratory Medicine, The Medical University of Silesia, Jedności 8, 41-200 Sosnowiec, Poland. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 Jan 12; Vol. 24 (2). Date of Electronic Publication: 2019 Jan 12.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Phenothiazines/*chemical synthesis
Phenothiazines/*pharmacology
Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Inhibitory Concentration 50 ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Phenothiazines/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Development of Yellow-to-Orange Photoluminescence Molecules Based on Alterations in the Donor Units of Fluorinated Tolanes.
Autorzy:
Yamada S; Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
Kobayashi K; Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
Konno T; Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Sep 07; Vol. 27 (18). Date of Electronic Publication: 2022 Sep 07.
Typ publikacji:
Journal Article
MeSH Terms:
Citrus sinensis*
Amines ; Carbazoles ; Phenothiazines ; Piperidines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tri- and Pentacyclic Azaphenothiazine as Pro-Apoptotic Agents in Lung Carcinoma with a Protective Potential to Healthy Cell Lines.
Autorzy:
Skonieczna M; Biotechnology Centre, Silesian University of Technology, 44-100 Gliwice, Poland.; Department of Systems Biology and Engineering, Faculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, 44-100 Gliwice, Poland.
Kasprzycka A; Biotechnology Centre, Silesian University of Technology, 44-100 Gliwice, Poland.; Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland.
Jeleń M; Department of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, The Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Morak-Młodawska B; Department of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, The Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Aug 17; Vol. 27 (16). Date of Electronic Publication: 2022 Aug 17.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Carcinoma*/drug therapy
Lung Neoplasms*/drug therapy
Lung Neoplasms*/pathology
Apoptosis ; Cell Line ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Lung/pathology ; Phenothiazines/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 1399

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