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Tytuł :
Comparisons of Four Protein-Binding Models Characterizing the Pharmacokinetics of Unbound Phenytoin in Adult Patients Using Non-Linear Mixed-Effects Modeling.
Autorzy :
Jun H; College of Pharmacy, Seoul National University, Seoul, Republic of Korea.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Katz Group Centre for Pharmacy and Health Research, Room 3-142D, 11361-87 Avenue, Edmonton, AB, T6G 2E1, Canada.
Rong Y; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Katz Group Centre for Pharmacy and Health Research, Room 3-142D, 11361-87 Avenue, Edmonton, AB, T6G 2E1, Canada.
Yih C; Department of Pharmacy, Vancouver General Hospital, Vancouver, BC, Canada.
Ho J; Department of Pharmacy, Vancouver General Hospital, Vancouver, BC, Canada.
Cheng W; Department of Pharmacy, Vancouver General Hospital, Vancouver, BC, Canada.
Kiang TKL; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Katz Group Centre for Pharmacy and Health Research, Room 3-142D, 11361-87 Avenue, Edmonton, AB, T6G 2E1, Canada. .
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Źródło :
Drugs in R&D [Drugs R D] 2020 Dec; Vol. 20 (4), pp. 343-358. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Anticonvulsants/*blood
Anticonvulsants/*pharmacokinetics
Phenytoin/*blood
Phenytoin/*pharmacokinetics
Adult ; Aged ; Aged, 80 and over ; Anticonvulsants/administration & dosage ; Drug Monitoring ; Female ; Humans ; Male ; Middle Aged ; Models, Biological ; Nonlinear Dynamics ; Phenytoin/administration & dosage ; Protein Binding ; Retrospective Studies ; Serum Albumin/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Incidence of hyponatremia in patients given levetiracetam vs. phenytoin for early posttraumatic seizure prophylaxis.
Autorzy :
Bilello JF; UCSF Fresno Department of Surgery, 2823 Fresno St., 1st Floor Surgery, Fresno, CA, USA, 93721. Electronic address: .
McCullough KA; UCSF Fresno Department of Surgery, 2823 Fresno St., 1st Floor Surgery, Fresno, CA, USA, 93721. Electronic address: .
Dirks RC; UCSF Fresno Department of Surgery, 2823 Fresno St., 1st Floor Surgery, Fresno, CA, USA, 93721. Electronic address: .
Davis JW; UCSF Fresno Department of Surgery, 2823 Fresno St., 1st Floor Surgery, Fresno, CA, USA, 93721. Electronic address: .
Edmonds NS; UCSF Fresno Department of Surgery, 2823 Fresno St., 1st Floor Surgery, Fresno, CA, USA, 93721. Electronic address: .
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Źródło :
American journal of surgery [Am J Surg] 2020 Dec; Vol. 220 (6), pp. 1503-1505. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Anticonvulsants/*adverse effects
Hyponatremia/*chemically induced
Hyponatremia/*epidemiology
Levetiracetam/*adverse effects
Phenytoin/*adverse effects
Seizures/*prevention & control
Adult ; Anticonvulsants/therapeutic use ; Brain Injuries, Traumatic/complications ; Early Medical Intervention ; Female ; Humans ; Incidence ; Levetiracetam/therapeutic use ; Male ; Middle Aged ; Phenytoin/therapeutic use ; Retrospective Studies ; Seizures/etiology ; Young Adult
Czasopismo naukowe
Tytuł :
An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.
Autorzy :
Chang WC; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia , Vancouver, British Columbia, Canada.; British Columbia Children's Hospital Research Institute , Vancouver, British Columbia, Canada.
Hung SI; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital , Linkou, Taipei, Taiwan.; College of Medicine, Chang Gung University , Taoyuan, Taiwan.; Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Immunology Consortium, Chang Gung Memorial Hospital , Linkou, Taiwan.; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital , Keelung, Taiwan.
Carleton BC; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia , Vancouver, British Columbia, Canada.; British Columbia Children's Hospital Research Institute , Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, BC Children's Hospital , Vancouver, British Columbia, Canada.
Chung WH; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital , Linkou, Taipei, Taiwan.; College of Medicine, Chang Gung University , Taoyuan, Taiwan.; Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Immunology Consortium, Chang Gung Memorial Hospital , Linkou, Taiwan.; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital , Keelung, Taiwan.; Department of Dermatology, Xiamen Chang Gung Hospital, Teaching Hospital of School of Medicine, Tsinghua University , China.; School of Medicine, Shanghai Jiao Tong University , Shanghai, China.
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Źródło :
Expert opinion on drug metabolism & toxicology [Expert Opin Drug Metab Toxicol] 2020 Aug; Vol. 16 (8), pp. 723-734. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anticonvulsants/*administration & dosage
Epilepsy/*drug therapy
Phenytoin/*administration & dosage
Anticonvulsants/adverse effects ; Anticonvulsants/pharmacokinetics ; Cytochrome P-450 CYP2C9/genetics ; HLA-B Antigens/genetics ; Humans ; Pharmacogenetics ; Phenytoin/adverse effects ; Phenytoin/pharmacokinetics ; Polymorphism, Genetic
Czasopismo naukowe
Tytuł :
Phenytoin - An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology.
Autorzy :
Patocka J; Faculty of Health and Social Studies, Department of Radiology and Toxicology, University of South Bohemia Ceske Budejovice, Ceske Budejovice, Czech Republic; Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.
Wu Q; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic; College of Life Science, Yangtze University, Jingzhou, 434025, China.
Nepovimova E; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Kuca K; Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2020 Aug; Vol. 142, pp. 111393. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anticonvulsants/*chemistry
Anticonvulsants/*pharmacology
Phenytoin/*chemistry
Phenytoin/*pharmacology
Anticonvulsants/toxicity ; Carcinogenicity Tests ; Humans ; Mutagenicity Tests ; Phenytoin/toxicity ; Teratogens/toxicity
Czasopismo naukowe
Tytuł :
Phenytoin and levetiracetam are equally effective second-line treatments for status epilepticus.
Autorzy :
Dalrymple RA; Department of General Paediatrics, Royal Hospital for Children Glasgow, Glasgow G83 0UA, UK .
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Źródło :
Archives of disease in childhood. Education and practice edition [Arch Dis Child Educ Pract Ed] 2020 Oct; Vol. 105 (5), pp. 319-320. Date of Electronic Publication: 2019 Dec 11.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Phenytoin*/therapeutic use
Status Epilepticus*/drug therapy
Anticonvulsants/therapeutic use ; Child ; Humans ; Levetiracetam/therapeutic use ; Research Design
Czasopismo naukowe
Tytuł :
Efficacy and safety profile of intravenous levetiracetam versus phenytoin in convulsive status epilepticus and acute repetitive seizures in children.
Autorzy :
Besli GE; Istanbul Medeniyet University Faculty of Medicine, Goztepe Training and Research Hospital, Department of Pediatric Emergency, Doktor Erkin C, 34730 Istanbul, Turkey. Electronic address: .
Yuksel Karatoprak E; Istanbul Medeniyet University Faculty of Medicine, Goztepe Training and Research Hospital, Department of Pediatric Neurology, Istanbul, Turkey.
Yilmaz S; Istanbul Medeniyet University Faculty of Medicine, Goztepe Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey.
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Źródło :
Epilepsy & behavior : E&B [Epilepsy Behav] 2020 Oct; Vol. 111, pp. 107289. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Anticonvulsants/*administration & dosage
Emergency Medical Services/*methods
Levetiracetam/*administration & dosage
Phenytoin/*administration & dosage
Seizures/*drug therapy
Status Epilepticus/*drug therapy
Administration, Intravenous ; Adolescent ; Anticonvulsants/adverse effects ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Levetiracetam/adverse effects ; Male ; Phenytoin/adverse effects ; Retrospective Studies ; Seizures/diagnosis ; Status Epilepticus/diagnosis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy.
Autorzy :
Kang Y; Laboratory of Stomatology, First-class Subjects of Zhejiang Province, College of Medicine and Health, Lishui University, Lishui, China.
Yang R; Laboratory of Stomatology, First-class Subjects of Zhejiang Province, College of Medicine and Health, Lishui University, Lishui, China.; Department of Pharmacology, College of Medicine and Health, Lishui University, Lishui, China.
Wei Z; Department of Pharmacology, College of Medicine and Health, Lishui University, Lishui, China.
Zhu D; Laboratory of Stomatology, First-class Subjects of Zhejiang Province, College of Medicine and Health, Lishui University, Lishui, China.
Tang T; Department of Anatomy, College of Medicine and Health, Lishui University, Lishui, China.
Zhu L; Department of Pharmacology, College of Medicine and Health, Lishui University, Lishui, China.
Hu X; Department of Pharmacology, College of Medicine and Health, Lishui University, Lishui, China.
Zha G; Laboratory of Stomatology, First-class Subjects of Zhejiang Province, College of Medicine and Health, Lishui University, Lishui, China.
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Źródło :
Journal of periodontal research [J Periodontal Res] 2020 Oct; Vol. 55 (5), pp. 642-650. Date of Electronic Publication: 2020 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*
Gingival Hyperplasia*/chemically induced
Gingival Hyperplasia*/metabolism
Phenytoin*/adverse effects
Voltage-Gated Sodium Channel Blockers*/pharmacology
Aging ; Fibroblasts ; Gingiva ; Humans
Czasopismo naukowe
Tytuł :
Phenytoin-loaded lipid-core nanocapsules improve the technological properties and in vivo performance of fluidised bed granules.
Autorzy :
de Oliveira EG; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
de Oliveira RS; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Zatta KC; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Furian AF; Departamento de Ciência e Tecnologia de Alimentos (UFSM), Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Oliveira MS; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Pohlmann AR; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Guterres SS; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Beck RCR; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: .
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Źródło :
Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2020 Jun; Vol. 111, pp. 110753. Date of Electronic Publication: 2020 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Anticonvulsants/*chemistry
Lipids/*chemistry
Nanocapsules/*chemistry
Phenytoin/*chemistry
Animals ; Anticonvulsants/metabolism ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Disease Models, Animal ; Drug Carriers/chemistry ; Drug Liberation ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/physiology ; Mice ; Mice, Inbred C57BL ; Particle Size ; Phenytoin/metabolism ; Phenytoin/pharmacology ; Phenytoin/therapeutic use ; Polysaccharides/chemistry ; Seizures/drug therapy ; Seizures/pathology ; Swine ; Tissue Adhesives/chemistry ; Tissue Adhesives/pharmacology
Czasopismo naukowe
Tytuł :
Budget Impact Analysis of Extended-Release Phenytoin Capsules Compared With Immediate-Release Phenytoin Capsules for Patients With Epilepsy in Thailand.
Autorzy :
Tiamkao S; Division of Neurology, Department of Medicine, Khon Kaen University, Khon Kaen, Thailand; Integrated Epilepsy Research Group, Khon Kaen University, Khon Kaen, Thailand. Electronic address: .
Suthipinijtham P; Pfizer (Thailand) Limited, Thailand.
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Źródło :
Value in health regional issues [Value Health Reg Issues] 2020 May; Vol. 21, pp. 22-28. Date of Electronic Publication: 2019 Oct 18.
Typ publikacji :
Journal Article
MeSH Terms :
Delayed-Action Preparations/*standards
Epilepsy/*drug therapy
Epilepsy/*economics
National Health Programs/*economics
Phenytoin/*administration & dosage
Anticonvulsants/administration & dosage ; Anticonvulsants/therapeutic use ; Capsules/administration & dosage ; Capsules/economics ; Capsules/therapeutic use ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/therapeutic use ; Humans ; National Health Programs/statistics & numerical data ; Phenytoin/standards ; Phenytoin/therapeutic use ; Thailand ; Time Factors
Czasopismo naukowe
Tytuł :
Determination of phenytoin in exhaled breath condensate using electromembrane extraction followed by capillary electrophoresis.
Autorzy :
Seyfinejad B; Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.; Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Meshkini A; Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Habibolahi P; Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Ozkan SA; Faculty of Pharmacy, Department of Analytical Chemistry, Ankara University, Ankara, Turkey.
Jouyban A; Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.; Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
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Źródło :
Electrophoresis [Electrophoresis] 2020 May; Vol. 41 (9), pp. 666-677. Date of Electronic Publication: 2020 Feb 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anticonvulsants/*analysis
Breath Tests/*methods
Electrophoresis, Capillary/*methods
Phenytoin/*analysis
Anticonvulsants/chemistry ; Anticonvulsants/isolation & purification ; Anticonvulsants/therapeutic use ; Chemical Fractionation ; Humans ; Hydrogen-Ion Concentration ; Limit of Detection ; Linear Models ; Membranes, Artificial ; Phenytoin/chemistry ; Phenytoin/isolation & purification ; Phenytoin/therapeutic use ; Reproducibility of Results ; Seizures/drug therapy
Czasopismo naukowe
Tytuł :
Three-ply biocompatible pH-responsive nanocarriers based on HNT sandwiched by chitosan/pectin layers for controlled release of phenytoin sodium.
Autorzy :
Jamshidzadeh F; Department of Chemistry, Amirkabir University of Technology, Iran.
Mohebali A; Department of Chemistry, Amirkabir University of Technology, Iran. Electronic address: .
Abdouss M; Department of Chemistry, Amirkabir University of Technology, Iran. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 May 01; Vol. 150, pp. 336-343. Date of Electronic Publication: 2020 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Hydrogen-Ion Concentration*
Biocompatible Materials/*chemistry
Chitosan/*chemistry
Drug Carriers/*chemistry
Pectins/*chemistry
Phenytoin/*pharmacokinetics
Chemical Phenomena ; Delayed-Action Preparations ; Drug Delivery Systems ; Phenytoin/administration & dosage ; Phenytoin/chemistry ; Spectrum Analysis
Czasopismo naukowe
Tytuł :
Phenytoin intoxication associated with omeprazole administration in a child with defective CYP2C9.
Autorzy :
Marano M; DEA Paediatric Intensive Care Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy. .; Regional Paediatric Poison Center, IRCCS Bambino Gesù Children's Hospital, Rome, Italy. .
Nicoletti F; Department of Physiology and Pharmacology, University Sapienza of Rome, Rome, Italy.; IRCCS Neuromed, Pozzilli, Italy.
Pro S; Neurology Unit, Department of Neurosciences, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.
Goffredo BM; Department of Pediatric Medicine, Laboratory of Metabolic Biochemistry Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.
Cecchetti C; DEA Paediatric Intensive Care Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Piervincenzi E; DEA Paediatric Intensive Care Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.; Department of Anaesthesia and Critical Care Medicine, University Sapienza of Rome, Rome, Italy.
Agolini E; Laboratory of Medical Genetics, Bambino Gesù Children's Hospital, Rome, Italy.
Cocciadiferro D; Laboratory of Medical Genetics, Bambino Gesù Children's Hospital, Rome, Italy.
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Źródło :
European journal of clinical pharmacology [Eur J Clin Pharmacol] 2020 May; Vol. 76 (5), pp. 731-732. Date of Electronic Publication: 2020 Jan 15.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Cytochrome P-450 CYP2C9/*metabolism
Omeprazole/*administration & dosage
Phenytoin/*adverse effects
Child, Preschool ; Cytochrome P-450 CYP2C19/metabolism ; Cytochrome P-450 CYP2C9/genetics ; Drug Interactions ; Genotype ; Humans ; Phenytoin/blood ; Polymorphism, Genetic
Raport
Tytuł :
A model-based analysis of phenytoin and carbamazepine toxicity treatment using binding-competition during hemodialysis.
Autorzy :
Maheshwari V; Renal Research Institute, 315 E, 62nd St, New York City, NY, 10065, USA. .
Hoffman RS; Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Thijssen S; Renal Research Institute, 315 E, 62nd St, New York City, NY, 10065, USA.
Tao X; Renal Research Institute, 315 E, 62nd St, New York City, NY, 10065, USA.
Fuertinger DH; Global Research & Development, Fresenius Medical Care, Bad Homburg, Germany.
Kotanko P; Renal Research Institute, 315 E, 62nd St, New York City, NY, 10065, USA.; Department of Nephrology, Icahn School of Medicine at Mount Sinai, New York, USA.
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 09; Vol. 10 (1), pp. 11294. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Chemical*
Renal Dialysis*
Aspirin/*metabolism
Carbamazepine/*metabolism
Ibuprofen/*metabolism
Phenytoin/*metabolism
Binding, Competitive ; Carbamazepine/toxicity ; Humans ; Phenytoin/toxicity ; Protein Binding
Czasopismo naukowe
Tytuł :
Choosing Anticonvulsant Medications to Manage Status Epilepticus.
Autorzy :
Wu K
Hirsch LJ
Babl FE
Josephson SA
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Źródło :
The New England journal of medicine [N Engl J Med] 2020 Jun 25; Vol. 382 (26), pp. 2569-2572.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Anticonvulsants/*therapeutic use
Levetiracetam/*therapeutic use
Phenytoin/*analogs & derivatives
Status Epilepticus/*drug therapy
Valproic Acid/*therapeutic use
Adult ; Disease Management ; Drug Therapy, Combination ; Epilepsy, Generalized/drug therapy ; Female ; Humans ; Midazolam/therapeutic use ; Phenytoin/therapeutic use
Czasopismo naukowe
Tytuł :
Impact of anti-epileptic drug choice on discharge in acute traumatic brain injury patients.
Autorzy :
Harris L; Neurolosurgical Department, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK. .
Hateley S; Neurology Department, Imperial College Healthcare NHS Trust, London, UK.
Tsang KT; Neurolosurgical Department, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK.
Wilson M; Neurolosurgical Department, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK.
Seemungal BM; Neuro-Otology Unit, Division of Brain Sciences, Imperial College London, London, UK. .
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Źródło :
Journal of neurology [J Neurol] 2020 Jun; Vol. 267 (6), pp. 1774-1779. Date of Electronic Publication: 2020 Mar 04.
Typ publikacji :
Comparative Study; Journal Article; Observational Study
MeSH Terms :
Length of Stay*
Anticonvulsants/*pharmacology
Brain Injuries, Traumatic/*therapy
Dizziness/*chemically induced
Levetiracetam/*pharmacology
Phenytoin/*pharmacology
Postural Balance/*drug effects
Seizures/*prevention & control
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anticonvulsants/adverse effects ; Brain Injuries, Traumatic/complications ; Female ; Glasgow Coma Scale ; Humans ; Levetiracetam/adverse effects ; Male ; Middle Aged ; Phenytoin/adverse effects ; Retrospective Studies ; Seizures/etiology ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
The association of patient weight and dose of fosphenytoin, levetiracetam, and valproic acid with treatment success in status epilepticus.
Autorzy :
Sathe AG; Department of Experimental and Clinical Pharmacology and Center for Orphan Drug Research, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota.
Elm JJ; Department of Public Health Science, Medical University of South Carolina, Charleston, South Carolina.
Cloyd JC; Department of Experimental and Clinical Pharmacology and Center for Orphan Drug Research, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota.
Chamberlain JM; Division of Emergency Medicine, Department of Pediatrics and Emergency Medicine, School of Medicine and Health Sciences, Children's National Hospital, George Washington University, Washington, District of Columbia.
Silbergleit R; Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan.
Kapur J; Department of Neurology, Brain Institute, University of Virginia, Charlottesville, Virginia.; Department of Neuroscience, Brain Institute, University of Virginia, Charlottesville, Virginia.
Cock HR; Clinical Neurosciences Academic Group, Institute of Molecular and Clinical Sciences, St George's University of London, London, UK.
Fountain NB; Department of Neurology, Comprehensive Epilepsy Program, University of Virginia, Charlottesville, Virginia.
Shinnar S; Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
Lowenstein DH; Department of Neurology, University of California, San Francisco, San Francisco, California.
Conwit RA; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Bleck TP; Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Coles LD; Department of Experimental and Clinical Pharmacology and Center for Orphan Drug Research, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota.
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Źródło :
Epilepsia [Epilepsia] 2020 Jun; Vol. 61 (6), pp. e66-e70. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anticonvulsants/*administration & dosage
Body Weight/*drug effects
Levetiracetam/*administration & dosage
Phenytoin/*analogs & derivatives
Status Epilepticus/*drug therapy
Valproic Acid/*administration & dosage
Adolescent ; Adult ; Body Weight/physiology ; Dose-Response Relationship, Drug ; Female ; Humans ; Male ; Phenytoin/administration & dosage ; Single-Blind Method ; Status Epilepticus/physiopathology ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial.
Autorzy :
Chamberlain JM; Division of Emergency Medicine Children's National Hospital, Washington, DC, USA.
Kapur J; Department of Neurology, University of Virginia Health Sciences Center, Charlottesville, VA, USA.
Shinnar S; Neurology, Pediatrics and Epidemiology and Population Health Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Elm J; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Holsti M; Division of Pediatric Emergency Medicine, University of Utah, Salt Lake City, UT, USA.
Babcock L; Division of Pediatric Emergency Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.
Rogers A; Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Barsan W; Department of Emergency Medicine, Neuro Emergencies Research, University of Michigan, Ann Arbor, MI, USA.
Cloyd J; Center for Orphan Drug Research, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Lowenstein D; Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Bleck TP; Division of Stroke and Neurocritical Care, Northwestern University Feinberg School of Medicine, Chicago, IL USA.
Conwit R; National Institute of Neurological Disorders and Stroke, National Institutes of Health Neuroscience Center, Bethesda, MD, USA.
Meinzer C; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Cock H; Institute of Molecular and Clinical Sciences, St George's University of London, London, UK.
Fountain NB; Department of Neurology, University of Virginia Health Sciences Center, Charlottesville, VA, USA.
Underwood E; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Connor JT; ConfluenceStat LLC and University of Central Florida College of Medicine, Cooper City, FL, USA.
Silbergleit R; Department of Emergency Medicine, Neuro Emergencies Research, University of Michigan, Ann Arbor, MI, USA. Electronic address: .
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Corporate Authors :
Neurological Emergencies Treatment Trials
Pediatric Emergency Care Applied Research Network investigators
Źródło :
Lancet (London, England) [Lancet] 2020 Apr 11; Vol. 395 (10231), pp. 1217-1224. Date of Electronic Publication: 2020 Mar 20.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Anticonvulsants/*administration & dosage
Levetiracetam/*administration & dosage
Phenytoin/*analogs & derivatives
Status Epilepticus/*drug therapy
Valproic Acid/*administration & dosage
Adolescent ; Adult ; Age Distribution ; Age Factors ; Aged ; Aged, 80 and over ; Anticonvulsants/adverse effects ; Child ; Child, Preschool ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Infant ; Levetiracetam/adverse effects ; Male ; Middle Aged ; Phenytoin/administration & dosage ; Phenytoin/adverse effects ; Valproic Acid/adverse effects ; Young Adult
Czasopismo naukowe
Tytuł :
Efficacy, Tolerability and Serum Phenytoin Levels after Intravenous Fosphenytoin Loading Dose in Children with Status Epilepticus.
Autorzy :
Srivastava K; Pediatric Neurology Unit, Department of Pediatrics, Bharati Vidyapeeth Deemed University Medical College, Pune, India. Correspondence to: Dr Kavita Srivastava, Professor in Pediatrics, 3rd floor, Bharati Hospital, Katraj, Pune 411 043, India. .
Bhartiya S; Pediatric Neurology Unit, Department of Pediatrics, Bharati Vidyapeeth Deemed University Medical College, Pune, India.
Gavli V; Pediatric Neurology Unit, Department of Pediatrics, Bharati Vidyapeeth Deemed University Medical College, Pune, India.
Patil R; Pediatric Neurology Unit, Department of Pediatrics, Bharati Vidyapeeth Deemed University Medical College, Pune, India.
Rajadhyaksha S; Pediatric Neurology Unit, Department of Pediatrics, Bharati Vidyapeeth Deemed University Medical College, Pune, India.
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Źródło :
Indian pediatrics [Indian Pediatr] 2020 Mar 15; Vol. 57 (3), pp. 218-221.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Anticonvulsants/*administration & dosage
Phenytoin/*analogs & derivatives
Status Epilepticus/*drug therapy
Administration, Intravenous ; Adolescent ; Anticonvulsants/pharmacokinetics ; Anticonvulsants/therapeutic use ; Biomarkers/blood ; Child ; Child, Preschool ; Dose-Response Relationship, Drug ; Female ; Humans ; Infant ; Linear Models ; Male ; Phenytoin/administration & dosage ; Phenytoin/blood ; Phenytoin/pharmacokinetics ; Phenytoin/therapeutic use ; Prospective Studies ; Status Epilepticus/blood ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Core-sheath gelatin based electrospun nanofibers for dual delivery release of biomolecules and therapeutics.
Autorzy :
Zandi N; Institute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box 11365-11155, Tehran, Iran.
Lotfi R; Institute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box 11365-11155, Tehran, Iran.
Tamjid E; Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.
Shokrgozar MA; National Cell Bank Department, Pasteur Institute of Iran, Tehran 13164, Iran.
Simchi A; Institute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box 11365-11155, Tehran, Iran; Department of Materials Science and Engineering, Sharif University of Technology, P.O. Box 11365-11155, Tehran, Iran. Electronic address: .
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Źródło :
Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2020 Mar; Vol. 108, pp. 110432. Date of Electronic Publication: 2019 Nov 15.
Typ publikacji :
Journal Article
MeSH Terms :
Gelatin*/chemistry
Gelatin*/pharmacology
Muramidase*/chemistry
Muramidase*/pharmacokinetics
Muramidase*/pharmacology
Phenytoin*/chemistry
Phenytoin*/pharmacokinetics
Phenytoin*/pharmacology
Polyvinyl Alcohol*/chemistry
Polyvinyl Alcohol*/pharmacology
Nanofibers/*chemistry
Animals ; Cell Line ; Delayed-Action Preparations/chemistry ; Delayed-Action Preparations/pharmacokinetics ; Delayed-Action Preparations/pharmacology ; Mice
Czasopismo naukowe

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