- Tytuł:
- Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1).
- Autorzy:
- Źródło:
- PloS one [PLoS One] 2012; Vol. 7 (1), pp. e29208. Date of Electronic Publication: 2012 Jan 18.
- Typ publikacji:
- Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
- MeSH Terms:
-
Depsipeptides/*pharmacology
Thiazoles/*pharmacology
Ubiquitin-Activating Enzymes/*antagonists & inhibitors
Ubiquitination/*drug effects
Adenine/metabolism ; Animals ; Cell Line ; Cyclin-Dependent Kinase Inhibitor p27/genetics ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Depsipeptides/chemistry ; Dose-Response Relationship, Drug ; Electrophoresis, Polyacrylamide Gel ; Enzyme Activation/drug effects ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HEK293 Cells ; Humans ; Immunoblotting ; Molecular Structure ; Telomeric Repeat Binding Protein 1/metabolism ; Thiazoles/chemistry ; Transfection ; Ubiquitin/metabolism ; Ubiquitin-Activating Enzymes/metabolism
Czasopismo naukowe