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Tytuł :
Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen-Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design.
Autorzy :
Eron SJ; C4 Therapeutics, Inc., 490 Arsenal Way Suite 200, Watertown, Massachusetts 02472, United States.
Huang H; C4 Therapeutics, Inc., 490 Arsenal Way Suite 200, Watertown, Massachusetts 02472, United States.
Agafonov RV; C4 Therapeutics, Inc., 490 Arsenal Way Suite 200, Watertown, Massachusetts 02472, United States.
Fitzgerald ME; C4 Therapeutics, Inc., 490 Arsenal Way Suite 200, Watertown, Massachusetts 02472, United States.
Patel J; C4 Therapeutics, Inc., 490 Arsenal Way Suite 200, Watertown, Massachusetts 02472, United States.
Michael RE; C4 Therapeutics, Inc., 490 Arsenal Way Suite 200, Watertown, Massachusetts 02472, United States.
Lee TD; C4 Therapeutics, Inc., 490 Arsenal Way Suite 200, Watertown, Massachusetts 02472, United States.
Hart AA; C4 Therapeutics, Inc., 490 Arsenal Way Suite 200, Watertown, Massachusetts 02472, United States.
Shaulsky J; Dassault Systèmes BIOVIA, 5005 Wateridge Vista Dr, San Diego, California 92121, United States.
Nasveschuk CG; C4 Therapeutics, Inc., 490 Arsenal Way Suite 200, Watertown, Massachusetts 02472, United States.
Phillips AJ; C4 Therapeutics, Inc., 490 Arsenal Way Suite 200, Watertown, Massachusetts 02472, United States.
Fisher SL; C4 Therapeutics, Inc., 490 Arsenal Way Suite 200, Watertown, Massachusetts 02472, United States.
Good A; C4 Therapeutics, Inc., 490 Arsenal Way Suite 200, Watertown, Massachusetts 02472, United States.
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Źródło :
ACS chemical biology [ACS Chem Biol] 2021 Nov 19; Vol. 16 (11), pp. 2228-2243. Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Contextualizing the Impact of Snakebite Envenoming on Patients: A Qualitative Content Analysis of Patient-Specific Functional Scale Activities Using the International Classification of Functioning, Disability and Health.
Autorzy :
Tupetz A; Division of Emergency Medicine, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Phillips AJ; Division of Emergency Medicine, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Kelly PE; Division of Emergency Medicine, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Barcenas LK; Division of Emergency Medicine, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Lavonas EJ; Department of Emergency Medicine, Denver Health and Hospital Authority, Denver, CO 80204, USA.
Vissoci JRN; Division of Emergency Medicine, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.; Duke Global Health Institute, Duke University, Durham, NC 27710, USA.
Gerardo CJ; Division of Emergency Medicine, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.; Duke Global Health Institute, Duke University, Durham, NC 27710, USA.
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Źródło :
International journal of environmental research and public health [Int J Environ Res Public Health] 2021 Sep 12; Vol. 18 (18). Date of Electronic Publication: 2021 Sep 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
International Classification of Functioning, Disability and Health*
Snake Bites*
Activities of Daily Living ; Adult ; Disability Evaluation ; Humans ; Prospective Studies
Czasopismo naukowe
Tytuł :
Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models.
Autorzy :
Sun D; Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania.; Institute of Life Sciences, Jiangsu University, Jinkou District, Zhenjiang, Jiangsu, China.
Nikonova AS; Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Zhang P; Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania.; Institute of Life Sciences, Jiangsu University, Jinkou District, Zhenjiang, Jiangsu, China.
Deneka AY; Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Fitzgerald ME; C4 Therapeutics, Inc., Watertown, Massachusetts.
Michael RE; C4 Therapeutics, Inc., Watertown, Massachusetts.
Lee L; C4 Therapeutics, Inc., Watertown, Massachusetts.
Lilly AC; Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania.; Drexel University College of Medicine, Philadelphia, Pennsylvania.
Fisher SL; C4 Therapeutics, Inc., Watertown, Massachusetts.
Phillips AJ; C4 Therapeutics, Inc., Watertown, Massachusetts.
Nasveschuk CG; C4 Therapeutics, Inc., Watertown, Massachusetts.
Proia DA; C4 Therapeutics, Inc., Watertown, Massachusetts.
Tu Z; Institute of Life Sciences, Jiangsu University, Jinkou District, Zhenjiang, Jiangsu, China. .
Golemis EA; Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania. .
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Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2021 Aug; Vol. 20 (8), pp. 1367-1377. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics.
Autorzy :
Simard JR; C4 Therapeutics, Inc., Watertown, MA, USA.
Lee L; C4 Therapeutics, Inc., Watertown, MA, USA.
Vieux E; C4 Therapeutics, Inc., Watertown, MA, USA.
Improgo R; C4 Therapeutics, Inc., Watertown, MA, USA.
Tieu T; C4 Therapeutics, Inc., Watertown, MA, USA.
Phillips AJ; C4 Therapeutics, Inc., Watertown, MA, USA.
Fisher SL; C4 Therapeutics, Inc., Watertown, MA, USA.
Pollock RM; C4 Therapeutics, Inc., Watertown, MA, USA.
Park E; C4 Therapeutics, Inc., Watertown, MA, USA.
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Źródło :
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Apr; Vol. 26 (4), pp. 503-517. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination.
Autorzy :
Vieux EF; C4 Therapeutics Inc., Watertown, MA, USA.
Agafonov RV; C4 Therapeutics Inc., Watertown, MA, USA.
Emerson L; C4 Therapeutics Inc., Watertown, MA, USA.
Isasa M; C4 Therapeutics Inc., Watertown, MA, USA.
Deibler RW; C4 Therapeutics Inc., Watertown, MA, USA.
Simard JR; C4 Therapeutics Inc., Watertown, MA, USA.
Cocozziello D; C4 Therapeutics Inc., Watertown, MA, USA.
Ladd B; C4 Therapeutics Inc., Watertown, MA, USA.
Lee L; C4 Therapeutics Inc., Watertown, MA, USA.
Li H; C4 Therapeutics Inc., Watertown, MA, USA.
Archer S; C4 Therapeutics Inc., Watertown, MA, USA.
Fitzgerald M; C4 Therapeutics Inc., Watertown, MA, USA.
Michael R; C4 Therapeutics Inc., Watertown, MA, USA.
Nasveschuk CG; C4 Therapeutics Inc., Watertown, MA, USA.
Park ES; C4 Therapeutics Inc., Watertown, MA, USA.
Kern G; C4 Therapeutics Inc., Watertown, MA, USA.
Proia DA; C4 Therapeutics Inc., Watertown, MA, USA.
Phillips AJ; C4 Therapeutics Inc., Watertown, MA, USA.
Fisher SL; C4 Therapeutics Inc., Watertown, MA, USA.
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Źródło :
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Apr; Vol. 26 (4), pp. 547-559.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Irregular sleep-wake patterns in older adults with current or remitted depression.
Autorzy :
Pye J; Healthy Brain Ageing Program, School of Psychology, University of Sydney, Australia; Susan Wakil School of Nursing and Midwifery, University of Sydney, Australia.
Phillips AJ; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Australia.
Cain SW; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Australia.
Montazerolghaem M; Institute of Medical Physics, School of Physics, University of Sydney, Australia.
Mowszowski L; Healthy Brain Ageing Program, School of Psychology, University of Sydney, Australia; Brain & Mind Centre, University of Sydney, Australia; Charles Perkins Centre, University of Sydney, Australia; CogSleep Centre of Research Excellence, National Health and Medical Research Council, Australia.
Duffy S; Brain & Mind Centre, University of Sydney, Australia; Charles Perkins Centre, University of Sydney, Australia; CogSleep Centre of Research Excellence, National Health and Medical Research Council, Australia; Faculty of Medicine and Health, University of Sydney, Australia.
Hickie IB; Brain & Mind Centre, University of Sydney, Australia; Faculty of Medicine and Health, University of Sydney, Australia.
Naismith SL; Healthy Brain Ageing Program, School of Psychology, University of Sydney, Australia; Brain & Mind Centre, University of Sydney, Australia; Charles Perkins Centre, University of Sydney, Australia; CogSleep Centre of Research Excellence, National Health and Medical Research Council, Australia. Electronic address: .
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Źródło :
Journal of affective disorders [J Affect Disord] 2021 Feb 15; Vol. 281, pp. 431-437. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Sleep Disorders, Circadian Rhythm*
Sleep Wake Disorders*
Actigraphy ; Aged ; Circadian Rhythm ; Depression ; Humans ; Sleep
Czasopismo naukowe
Tytuł :
Community nurses' support for patients with fibromyalgia who use cannabis to manage pain.
Autorzy :
Andrews NJ; Student in Health Studies, Canterbury Christ Church University, Kent.
Phillips AJ; Senior Lecturer in Health Promotion and Public Health, Canterbury Christ Church University, Kent.
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Źródło :
British journal of community nursing [Br J Community Nurs] 2021 Feb 02; Vol. 26 (2), pp. 92-98.
Typ publikacji :
Journal Article
MeSH Terms :
Cannabis*
Chronic Pain*/drug therapy
Fibromyalgia*/drug therapy
Nurses*
Analgesics ; Humans
Czasopismo naukowe
Tytuł :
What would it take to describe the global diversity of parasites?
Autorzy :
Carlson CJ; Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057, USA.; Center for Global Health Science and Security, Georgetown University, Washington, DC, USA.
Dallas TA; Centre for Ecological Change, University of Helsinki, 00840 Helsinki, Finland.
Alexander LW; Department of Integrative Biology, University of California, Berkeley, CA, USA.
Phelan AL; Center for Global Health Science and Security, Georgetown University, Washington, DC, USA.; O'Neill Institute for National and Global Health Law, Georgetown University Law Center, Washington, DC, USA.
Phillips AJ; Department of Invertebrate Zoology, National Museum of Natural History, Smithsonian Institution, Washington, DC 20013, USA.
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Źródło :
Proceedings. Biological sciences [Proc Biol Sci] 2020 Nov 25; Vol. 287 (1939), pp. 20201841. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article
MeSH Terms :
Biodiversity*
Helminths*
Host-Parasite Interactions*
Parasites*
Animals ; Fishes ; Humans ; Vertebrates
Czasopismo naukowe
Tytuł :
Re: Lasting lessons learnt in the radiology department from the battle with COVID-19. A reply.
Autorzy :
Loughborough WW; Royal United Hospitals Bath NHS Foundation Trust, Combe Park, Bath, BA1 3NG, UK.
Hudson BJ; Royal United Hospitals Bath NHS Foundation Trust, Combe Park, Bath, BA1 3NG, UK.
Nicolle E; Royal United Hospitals Bath NHS Foundation Trust, Combe Park, Bath, BA1 3NG, UK.
Phillips AJ; Royal United Hospitals Bath NHS Foundation Trust, Combe Park, Bath, BA1 3NG, UK.
Rodrigues JCL; Royal United Hospitals Bath NHS Foundation Trust, Combe Park, Bath, BA1 3NG, UK. Electronic address: .
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Źródło :
Clinical radiology [Clin Radiol] 2020 Oct; Vol. 75 (10), pp. 790-791. Date of Electronic Publication: 2020 Jul 11.
Typ publikacji :
Letter; Comment
MeSH Terms :
Betacoronavirus*
Coronavirus Infections*
Pandemics*
Pneumonia, Viral*
COVID-19 ; Humans ; SARS-CoV-2
Opinia redakcyjna
Tytuł :
Leeches in the extreme: Morphological, physiological, and behavioral adaptations to inhospitable habitats.
Autorzy :
Phillips AJ; Department of Invertebrate Zoology, National Museum of Natural History, Smithsonian Institution, 10th Street and Constitution Avenue NW, Washington, DC, 20560, USA.
Govedich FR; Biology Department, Southern Utah University, 351 W. University Blvd., Cedar City, UT, 84720, USA.
Moser WE; Department of Invertebrate Zoology, National Museum of Natural History, Smithsonian Institution, Museum Support Center-MRC 534, 4210 Silver Hill Road, Suitland, MD, 20746, USA.
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Źródło :
International journal for parasitology. Parasites and wildlife [Int J Parasitol Parasites Wildl] 2020 Sep 19; Vol. 12, pp. 318-325. Date of Electronic Publication: 2020 Sep 19 (Print Publication: 2020).
Typ publikacji :
Journal Article
Czasopismo naukowe

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