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Wyszukujesz frazę ""Phosphatidylinositol 3-Kinases"" wg kryterium: Temat


Tytuł :
Single-nucleotide variant of PIK3CA gene assay by CRISPR/Cas12a combined with rolling circle amplification.
Autorzy :
Cao G; Key Laboratory of Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400044, PR China.
Chen X; Key Laboratory of Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400044, PR China.
Deng Y; Key Laboratory of Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400044, PR China.
Nie F; Key Laboratory of Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400044, PR China; Key Laboratory of Cattle Diseases Detection (Chongqing), Diagnosis and Testing Laboratory of Lumpy Skin Disease, Chongqing Customs Technology Center, Chongqing, 400044, PR China.
Liu Y; Key Laboratory of Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400044, PR China.
Wang G; Key Laboratory of Cattle Diseases Detection (Chongqing), Diagnosis and Testing Laboratory of Lumpy Skin Disease, Chongqing Customs Technology Center, Chongqing, 400044, PR China.
Huo D; Key Laboratory of Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400044, PR China; Chongqing Key Laboratory of Bio-perception & Intelligent Information Processing, School of Microelectronics and Communication Engineering, Chongqing University, Chongqing, 400044, PR China. Electronic address: .
Hou C; Key Laboratory of Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400044, PR China. Electronic address: .
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Źródło :
Analytica chimica acta [Anal Chim Acta] 2021 Oct 16; Vol. 1182, pp. 338943. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
CRISPR-Cas Systems*/genetics
Phosphatidylinositol 3-Kinases*/genetics
Class I Phosphatidylinositol 3-Kinases/genetics ; Humans ; Mutation ; Nucleotides
Czasopismo naukowe
Tytuł :
A review of mechanisms of disease across PIK3CA-related disorders with vascular manifestations.
Autorzy :
Canaud G; Overgrowth Syndrome and Vascular Anomalies Unit, Hôpital Necker Enfants Malades, INSERM U1151, Assistance Publique-Hôpitaux de Paris, Université de Paris, 149 rue de Sèvres, 75105, Paris, France. .
Hammill AM; Division of Hematology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Adams D; Division of Oncology, Comprehensive Vascular Anomalies Program, Children's Hospital of Philadelphia, Perelman School of Medicine and the University of Pennsylvania, Philadelphia, PA, USA.
Vikkula M; Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium.; Center for Vascular Anomalies, Division of Plastic Surgery, Cliniques Universitaires Saint Luc, University of Louvain, Brussels, Belgium.; VASCERN VASCA European Reference Centre, Bichat-Claude Bernard Hospital, Paris, France.; Walloon Excellence in Lifesciences and Biotechnology (WELBIO), University of Louvain, Brussels, Belgium.
Keppler-Noreuil KM; Division of Genetics and Metabolism, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
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Źródło :
Orphanet journal of rare diseases [Orphanet J Rare Dis] 2021 Jul 08; Vol. 16 (1), pp. 306. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Growth Disorders*
Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Class I Phosphatidylinositol 3-Kinases/genetics ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Humans ; Mutation ; Signal Transduction
Czasopismo naukowe
Tytuł :
Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans.
Autorzy :
Yue Q; Drug Metabolism and Pharmacokinetics, Genentech Inc, South San Francisco, CA, USA.
Khojasteh SC; Drug Metabolism and Pharmacokinetics, Genentech Inc, South San Francisco, CA, USA.
Cho S; Drug Metabolism and Pharmacokinetics, Genentech Inc, South San Francisco, CA, USA.
Ma S; Drug Metabolism and Pharmacokinetics, Genentech Inc, South San Francisco, CA, USA.
Mulder T; Drug Metabolism and Pharmacokinetics, Genentech Inc, South San Francisco, CA, USA.
Chen J; Drug Metabolism and Pharmacokinetics, Genentech Inc, South San Francisco, CA, USA.
Pang J; Drug Metabolism and Pharmacokinetics, Genentech Inc, South San Francisco, CA, USA.
Ding X; Drug Metabolism and Pharmacokinetics, Genentech Inc, South San Francisco, CA, USA.
Deese A; Small Molecule Pharmaceutical Sciences, Genentech Inc, South San Francisco, CA, USA.
Pellet JD; Small Molecule Pharmaceutical Sciences, Genentech Inc, South San Francisco, CA, USA.
Siebers N; Covance Clinical Research Unit, 3402 Kinsman Boulevard, Madison, WI, USA.
Joas L; Covance Clinical Research Unit, 3402 Kinsman Boulevard, Madison, WI, USA.
Salphati L; Drug Metabolism and Pharmacokinetics, Genentech Inc, South San Francisco, CA, USA.
Ware JA; Clinical Pharmacology, Genentech Inc, South San Francisco, CA, USA.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jul; Vol. 51 (7), pp. 796-810. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Indazoles*
Phosphatidylinositol 3-Kinases*
Animals ; Class I Phosphatidylinositol 3-Kinases ; Dogs ; Feces ; Humans ; Phosphatidylinositols ; Rats ; Sulfonamides
Czasopismo naukowe
Tytuł :
Distinct epithelial-to-mesenchymal transitions induced by PIK3CA and PIK3CB .
Autorzy :
Gjelaj E; Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Hamel PA; Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada .
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Źródło :
Journal of cell science [J Cell Sci] 2021 Feb 17; Vol. 134 (4). Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Phosphatidylinositol 3-Kinase*
Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Class I Phosphatidylinositol 3-Kinases/genetics ; Epithelial-Mesenchymal Transition/genetics ; Humans ; Signal Transduction
Czasopismo naukowe
Tytuł :
MEX3A promotes development and progression of breast cancer through regulation of PIK3CA.
Autorzy :
Shi X; Department of General Surgery, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Sun Y; School of Medicine, Southeast University, Nanjing, China.
Zhang Y; Department of General Surgery, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Wang W; Department of General Surgery, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Xu J; Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China.
Guan Y; School of Medicine, Southeast University, Nanjing, China.
Ding Y; Department of General Surgery, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: .
Yao Y; Department of General Surgery, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Jul 01; Vol. 404 (1), pp. 112580. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*metabolism
Cell Proliferation/*physiology
Class I Phosphatidylinositol 3-Kinases/*metabolism
Gene Expression Regulation, Neoplastic/*genetics
Phosphoproteins/*metabolism
RNA-Binding Proteins/*metabolism
Breast Neoplasms/genetics ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Line, Tumor ; Cell Movement/physiology ; Class I Phosphatidylinositol 3-Kinases/genetics ; Female ; Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoproteins/genetics ; RNA-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Clinical experience with the AKT1 inhibitor miransertib in two children with PIK3CA-related overgrowth syndrome.
Autorzy :
Forde K; Dermatology, Children's Health Ireland at Crumlin, Dublin 12, Ireland.
Resta N; Department of Biomedical Sciences and Human Oncology (DIMO), Division of Medical Genetics, University of Bari 'Aldo Moro', 70124, Bari, Italy.
Ranieri C; Department of Biomedical Sciences and Human Oncology (DIMO), Division of Medical Genetics, University of Bari 'Aldo Moro', 70124, Bari, Italy.
Rea D; Clinical Imaging, Children's Health Ireland at Crumlin, Dublin 12, Ireland.
Kubassova O; Image Group Analysis (IAG), London, UK.
Hinton M; Image Group Analysis (IAG), London, UK.
Andrews KA; University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.; Department of Clinical Genetics, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.
Semple R; University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Irvine AD; Dermatology, Children's Health Ireland at Crumlin, Dublin 12, Ireland. .; Clinical Medicine, Trinity College Dublin, Dublin, Ireland. .
Dvorakova V; Dermatology, Children's Health Ireland at Crumlin, Dublin 12, Ireland.
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Źródło :
Orphanet journal of rare diseases [Orphanet J Rare Dis] 2021 Feb 27; Vol. 16 (1), pp. 109. Date of Electronic Publication: 2021 Feb 27.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Phosphatidylinositol 3-Kinases*
Quality of Life*
Aminopyridines ; Child ; Class I Phosphatidylinositol 3-Kinases/genetics ; Humans ; Imidazoles ; Mutation ; Proto-Oncogene Proteins c-akt/genetics
Czasopismo naukowe
Tytuł :
The complex balance of PI3K inhibition.
Autorzy :
Vanacker H; Department of Medical Oncology, Centre Léon Bérard, Lyon, France.
Cassier PA; Department of Medical Oncology, Centre Léon Bérard, Lyon, France.
Bachelot T; Department of Medical Oncology, Centre Léon Bérard, Lyon, France. Electronic address: .
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Źródło :
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2021 Feb; Vol. 32 (2), pp. 127-128. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Breast Neoplasms*
Phosphatidylinositol 3-Kinases*/genetics
Class I Phosphatidylinositol 3-Kinases ; Fulvestrant ; Humans ; Imidazoles ; Oxazepines ; Receptors, Estrogen
Opinia redakcyjna
Tytuł :
Somatic frameshift mutation in PIK3CA causes CLOVES syndrome by provoking PI3K/AKT/mTOR pathway.
Autorzy :
Yan W; Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses and National Clinical Research Center for Skin and Immune Diseases, 8 Xishiku St, Beijing, 100034, China.
Zhang B; Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No.56 Nanlishi Road, Xicheng District, Beijing, 100045, China.; Department of Dermatology, Zhengzhou University, Affiliated Children's Hospital, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450000, Henan, China.
Wang H; Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses and National Clinical Research Center for Skin and Immune Diseases, 8 Xishiku St, Beijing, 100034, China.
Mo R; Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses and National Clinical Research Center for Skin and Immune Diseases, 8 Xishiku St, Beijing, 100034, China.
Jiang X; Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses and National Clinical Research Center for Skin and Immune Diseases, 8 Xishiku St, Beijing, 100034, China.
Qin W; Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses and National Clinical Research Center for Skin and Immune Diseases, 8 Xishiku St, Beijing, 100034, China.
Ma L; Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No.56 Nanlishi Road, Xicheng District, Beijing, 100045, China. .; Department of Dermatology, Zhengzhou University, Affiliated Children's Hospital, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450000, Henan, China. .
Lin Z; Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses and National Clinical Research Center for Skin and Immune Diseases, 8 Xishiku St, Beijing, 100034, China. .
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Źródło :
Hereditas [Hereditas] 2021 Jun 01; Vol. 158 (1), pp. 18. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Frameshift Mutation*
Class I Phosphatidylinositol 3-Kinases/*genetics
Lipoma/*genetics
Musculoskeletal Abnormalities/*genetics
Nevus/*genetics
Vascular Malformations/*genetics
Child ; Female ; HEK293 Cells ; Humans ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases
SCR Disease Name :
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi
Czasopismo naukowe
Tytuł :
Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ.
Autorzy :
Martinez NG; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, United States.
Thieker DF; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, United States; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, United States.
Carey LM; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, United States; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, United States.
Rasquinha JA; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, United States.
Kistler SK; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, United States.
Kuhlman BA; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, United States; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, United States.
Campbell SL; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, United States; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, United States. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Apr 16; Vol. 433 (8), pp. 166838. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Interaction Domains and Motifs*
Class Ib Phosphatidylinositol 3-Kinase/*chemistry
Class Ib Phosphatidylinositol 3-Kinase/*metabolism
Phosphatidylinositol 3-Kinases/*chemistry
Phosphatidylinositol 3-Kinases/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Class I Phosphatidylinositol 3-Kinases ; Class Ib Phosphatidylinositol 3-Kinase/drug effects ; Class Ib Phosphatidylinositol 3-Kinase/genetics ; Drug Discovery ; Humans ; Mice ; Mutation ; Phosphatidylinositol 3-Kinases/drug effects ; Phosphatidylinositol 3-Kinases/genetics ; Phosphorylation ; Protein Binding ; Protein Conformation ; Protein Isoforms ; Sequence Alignment ; Signal Transduction ; ras Proteins/chemistry ; ras Proteins/genetics ; ras Proteins/metabolism
Czasopismo naukowe
Tytuł :
PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects.
Autorzy :
Mishra R; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
Patel H; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
Alanazi S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
Kilroy MK; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
Garrett JT; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 27; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Signal Transduction*
Neoplasms/*drug therapy
Neovascularization, Pathologic/*drug therapy
Phosphatidylinositol 3-Kinases/*metabolism
Phosphoinositide-3 Kinase Inhibitors/*pharmacology
Animals ; Antineoplastic Agents/pharmacology ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Clinical Trials as Topic ; Drug Resistance, Neoplasm/drug effects ; Drug-Related Side Effects and Adverse Reactions/drug therapy ; Humans ; Insulin/metabolism ; Mice ; Mutation ; Neoplasms/enzymology ; Protein Isoforms ; RNA, Untranslated/metabolism ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Nickel induces autophagy via PI3K/AKT/mTOR and AMPK pathways in mouse kidney.
Autorzy :
Yin H; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Zuo Z; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Yang Z; Chengdu Academy of Agriculture and Forestry Sciences, Chengdu, Sichuan 611130, PR China.
Guo H; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China. Electronic address: .
Fang J; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China. Electronic address: .
Cui H; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Ouyang P; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Chen X; Chengdu Academy of Agriculture and Forestry Sciences, Chengdu, Sichuan 611130, PR China.
Chen J; Chengdu Academy of Agriculture and Forestry Sciences, Chengdu, Sichuan 611130, PR China.
Geng Y; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Chen Z; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Huang C; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
Zhu Y; College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Oct 15; Vol. 223, pp. 112583. Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Animals ; Autophagy ; Kidney/metabolism ; Mice ; Nickel ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Copper exposure induces hepatic G0/G1 cell-cycle arrest through suppressing the Ras/PI3K/Akt signaling pathway in mice.
Autorzy :
Liu H; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China.
Deng H; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China.
Jian Z; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China.
Cui H; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China; Key Laboratory of Agricultural information engineering of Sichuan Province, Sichuan Agriculture University, Yaan, Sichuan 625014, China. Electronic address: .
Guo H; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China. Electronic address: .
Fang J; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China.
Zuo Z; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China.
Deng J; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China.
Li Y; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China.
Wang X; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China.
Zhao L; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China.
Zhu Y; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China.
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Oct 01; Vol. 222, pp. 112518. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation ; Copper/toxicity ; G1 Phase Cell Cycle Checkpoints ; Glycogen Synthase Kinase 3 ; Mice ; Signal Transduction
Czasopismo naukowe
Tytuł :
PI3K regulates the activation of NLRP3 inflammasome in atherosclerosis through part-dependent AKT signaling pathway.
Autorzy :
Liu Z; Department of Cardiology, 2th Affiliated Hospital of Dalian Medical University, Zhongshan Road No. 467, Dalian 116000, P.R. China.
Li J; Department of Cardiology, 2th Affiliated Hospital of Dalian Medical University, Zhongshan Road No. 467, Dalian 116000, P.R. China.
Lin S; Department of Cardiology, The University of Hong Kong-Shenzhen Hospital, Haiyuan 1st Road, Futian District, Shenzhen 518053, P.R. China.
Wu Y; Department of Cardiology, 2th Affiliated Hospital of Dalian Medical University, Zhongshan Road No. 467, Dalian 116000, P.R. China.
He D; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, No.49 Huanyuan Road, Beijing 100191, P.R. China.; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, No.49 Huanyuan Road, Beijing 100191, P.R. China.
Qu P; Department of Cardiology, 2th Affiliated Hospital of Dalian Medical University, Zhongshan Road No. 467, Dalian 116000, P.R. China.
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Źródło :
Experimental animals [Exp Anim] 2021 Nov 10; Vol. 70 (4), pp. 488-497. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Atherosclerosis/*genetics
Class I Phosphatidylinositol 3-Kinases/*genetics
Inflammasomes/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*genetics
Proto-Oncogene Proteins c-akt/*physiology
Animals ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Male ; Mice ; Mice, Knockout ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Bioisosteric replacements of the indole moiety for the development of a potent and selective PI3Kδ inhibitor: Design, synthesis and biological evaluation.
Autorzy :
Yang C; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Xu C; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Li Z; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Chen Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Wu T; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Hong H; Lyrae Therapeutics, L.L.C., Shanghai, 200438, China.
Lu M; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Jia Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Yang Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Liu X; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Deng M; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Chen Z; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
Li Q; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: .
Ling Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China; Zhuhai-Fudan Innovation Institute, Zhuhai, Guangdong, 519000, China. Electronic address: .
Zhou Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113661. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Class I Phosphatidylinositol 3-Kinases/*antagonists & inhibitors
Indoles/*chemistry
Phosphoinositide-3 Kinase Inhibitors/*chemical synthesis
Animals ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Class I Phosphatidylinositol 3-Kinases/metabolism ; G1 Phase Cell Cycle Checkpoints/drug effects ; Half-Life ; Humans ; Indoles/metabolism ; Indoles/pharmacology ; Indoles/therapeutic use ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/pathology ; Mice ; Mice, Nude ; Molecular Docking Simulation ; Phosphoinositide-3 Kinase Inhibitors/metabolism ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; Phosphoinositide-3 Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
[IGF-1 activates the PI3K pathway through S1P/S1PR1 signaling to promote the migration of mouse alveolar epithelial cells].
Autorzy :
Geng J; Department of Laboratory Management, School of Laboratory Medicine, Bengbu Medical College; Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu 233030, China.
Mu M; Department of Immunology, School of Laboratory Medicine, Bengbu Medical College; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical College, Bengbu 233030, China.
Ji C; Department of Immunology, School of Laboratory Medicine, Bengbu Medical College; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical College, Bengbu 233030, China.
Li M; Bengbu Medical College Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical College, Bengbu 233030, China.
Ma L; Bengbu Medical College Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical College, Bengbu 233030, China.
Wang Z; Department of Immunology, School of Laboratory Medicine, Bengbu Medical College; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical College, Bengbu 233030, China.
Hua M; Department of Immunology, School of Laboratory Medicine, Bengbu Medical College; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical College, Bengbu 233030, China.
Song C; Department of Immunology, School of Laboratory Medicine, Bengbu Medical College; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical College, Bengbu 233030, China. *Corresponding author, E-mail: .
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Źródło :
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2021 Nov; Vol. 37 (11), pp. 996-1002.
Typ publikacji :
Journal Article
MeSH Terms :
Phosphatidylinositol 3-Kinases*
Sphingosine*/pharmacology
Alveolar Epithelial Cells ; Animals ; Insulin-Like Growth Factor I ; Mice ; Proto-Oncogene Proteins c-akt ; Receptors, Lysosphingolipid/genetics
Czasopismo naukowe
Tytuł :
Reproductive toxicity of folpet through deregulation of calcium homeostasis in porcine trophectoderm and luminal epithelial cells during early pregnancy.
Autorzy :
Park S; Department of Plant and Biomaterials Science, Gyeongsang National University, Jinju 52725, Republic of Korea.
Yun BH; Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Bae H; Department of Oriental Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 17104, Republic of Korea.
Lim W; Department of Food and Nutrition, Kookmin University, Seoul 02707, Republic of Korea.. Electronic address: .
Song G; Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address: .
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Źródło :
Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2021 Nov; Vol. 179, pp. 104974. Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium*
Phosphatidylinositol 3-Kinases*
Animals ; Epithelial Cells ; Homeostasis ; Phthalimides ; Pregnancy ; Swine
Czasopismo naukowe
Tytuł :
H3K9ac modification was involved in doxorubicin induced apoptosis by regulating Pik3ca transcription in H9C2 cells.
Autorzy :
Yang L; Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, PR China; Department of Cardiology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, PR China.
Yu Y; Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, PR China; Department of Cardiology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, PR China.
Tian G; Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, PR China; Department of Cardiology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, PR China.
Deng H; Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, PR China; Department of Cardiology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, PR China.
Yu B; Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, PR China; Department of Cardiology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 01; Vol. 284, pp. 119107. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Apoptosis*/genetics
Transcription, Genetic*/drug effects
Class I Phosphatidylinositol 3-Kinases/*genetics
Doxorubicin/*pharmacology
Histones/*metabolism
Lysine/*metabolism
Acetylation/drug effects ; Animals ; Base Sequence ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Gene Silencing/drug effects ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Signal Transduction/drug effects ; Transcription Initiation Site ; Up-Regulation/drug effects ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
3'-Oxo-tabernaelegantine A (OTNA) selectively relaxes pulmonary arteries by inhibiting AhR.
Autorzy :
Long P; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China.
Li Y; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China; School of Pharmacy, North Sichuan Medical College, Nanchong 637100, China.
Wen Q; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China.
Huang M; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China.
Li S; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China.
Lin Y; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China.
Huang X; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China.
Chen M; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China.
Ouyang J; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China.
Ao Y; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China.
Qi Q; Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China.
Zhang H; Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China.
Ye W; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China.
Cheng G; College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: .
Zhang X; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China. Electronic address: .
Zhang D; College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Nov; Vol. 92, pp. 153751. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji :
Journal Article
MeSH Terms :
Phosphatidylinositol 3-Kinases*/metabolism
Pulmonary Artery*/metabolism
Animals ; Endothelial Cells/metabolism ; Endothelium, Vascular/metabolism ; Indole Alkaloids ; Mice ; Molecular Docking Simulation ; Nitric Oxide ; Nitric Oxide Synthase Type III/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Aryl Hydrocarbon/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
The Cellular Mechanisms of Dopamine Modulation on the Neuronal Network Oscillations in the CA3 Area of Rat Hippocampal Slices.
Autorzy :
Xie X; Henan International-Joint Laboratory for Non-invasive Neural Modulation/The Key Laboratory for the Brain Research of Henan Province, Department of Physiology, Xinxiang Medical University, Xinxiang 453003, China; The Second Hospital of Jinhua, Jinhua, Zhejiang 321000, China.
Li M; Henan International-Joint Laboratory for Non-invasive Neural Modulation/The Key Laboratory for the Brain Research of Henan Province, Department of Physiology, Xinxiang Medical University, Xinxiang 453003, China; Key Laboratory of Clinical Psychopharmacology, School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China.
Feng B; Henan International-Joint Laboratory for Non-invasive Neural Modulation/The Key Laboratory for the Brain Research of Henan Province, Department of Physiology, Xinxiang Medical University, Xinxiang 453003, China.
Li J; Henan International-Joint Laboratory for Non-invasive Neural Modulation/The Key Laboratory for the Brain Research of Henan Province, Department of Physiology, Xinxiang Medical University, Xinxiang 453003, China.
Sun Z; Henan International-Joint Laboratory for Non-invasive Neural Modulation/The Key Laboratory for the Brain Research of Henan Province, Department of Physiology, Xinxiang Medical University, Xinxiang 453003, China.
Zhao Y; Key Laboratory of Clinical Psychopharmacology, School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China.
Lu C; Henan International-Joint Laboratory for Non-invasive Neural Modulation/The Key Laboratory for the Brain Research of Henan Province, Department of Physiology, Xinxiang Medical University, Xinxiang 453003, China. Electronic address: .
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Źródło :
Neuroscience [Neuroscience] 2021 Nov 01; Vol. 475, pp. 83-92. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopamine*
Phosphatidylinositol 3-Kinases*
Animals ; Hippocampus ; Kainic Acid ; Neurons ; Rats
Czasopismo naukowe
Tytuł :
Effects of PI3K inhibition in AI-resistant breast cancer cell lines: autophagy, apoptosis, and cell cycle progression.
Autorzy :
Augusto TV; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, UCIBIO.REQUIMTE, University of Porto, Rua Jorge Viterbo Ferreira no. 228, 4050-313, Porto, Portugal.
Amaral C; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, UCIBIO.REQUIMTE, University of Porto, Rua Jorge Viterbo Ferreira no. 228, 4050-313, Porto, Portugal.
Wang Y; Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Chen S; Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Almeida CF; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, UCIBIO.REQUIMTE, University of Porto, Rua Jorge Viterbo Ferreira no. 228, 4050-313, Porto, Portugal.
Teixeira N; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, UCIBIO.REQUIMTE, University of Porto, Rua Jorge Viterbo Ferreira no. 228, 4050-313, Porto, Portugal. .
Correia-da-Silva G; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, UCIBIO.REQUIMTE, University of Porto, Rua Jorge Viterbo Ferreira no. 228, 4050-313, Porto, Portugal. .
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Źródło :
Breast cancer research and treatment [Breast Cancer Res Treat] 2021 Nov; Vol. 190 (2), pp. 227-240. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article
MeSH Terms :
Aromatase Inhibitors*/pharmacology
Breast Neoplasms*/drug therapy
Breast Neoplasms*/genetics
Phosphatidylinositol 3-Kinases*/genetics
Apoptosis ; Autophagy ; Cell Cycle ; Drug Resistance, Neoplasm ; Female ; Humans ; MCF-7 Cells
Czasopismo naukowe

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