Temat: "Phosphatidylinositol 3-Kinases" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Targeted treatment of severe vascular malformations harboring PIK3CA and TEK mutations with alpelisib is highly effective with limited toxicity.
Autorzy:: Sterba M; Department of Paediatrics, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czech Republic.; Department of Paediatric Oncology, Faculty of Medicine, University Hospital Brno, Masaryk University, Cernopolni 212/9, 613 00, Brno, Czech Republic.
Pokorna P; Department of Biology, Faculty of Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Faberova R; Department of Paediatrics, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czech Republic.
Pinkova B; Department of Paediatrics, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czech Republic.
Skotakova J; Department of Paediatric Radiology, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czech Republic.
Seehofnerova A; Department of Paediatric Radiology, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czech Republic.
Blatny J; Department of Paediatrics, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czech Republic.
Janigova L; Department of Paediatric Oncology, Faculty of Medicine, University Hospital Brno, Masaryk University, Cernopolni 212/9, 613 00, Brno, Czech Republic.
Koskova O; Department of Paediatric Surgery, Orthopaedics and Traumatology, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czech Republic.
Palova H; Department of Biology, Faculty of Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Mahdal M; 1st Department of Orthopaedics, Faculty of Medicine, St. Anne's University Hospital Brno, Masaryk University, Brno, Czech Republic.
Pazourek L; 1st Department of Orthopaedics, Faculty of Medicine, St. Anne's University Hospital Brno, Masaryk University, Brno, Czech Republic.
Jabandziev P; Department of Paediatrics, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czech Republic.; Department of Biology, Faculty of Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Slaby O; Department of Biology, Faculty of Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Mudry P; Department of Paediatric Oncology, Faculty of Medicine, University Hospital Brno, Masaryk University, Cernopolni 212/9, 613 00, Brno, Czech Republic. .; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic. .
Sterba J; Department of Paediatric Oncology, Faculty of Medicine, University Hospital Brno, Masaryk University, Cernopolni 212/9, 613 00, Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jun 28; Vol. 13 (1), pp. 10499. Date of Electronic Publication: 2023 Jun 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Phosphatidylinositol 3-Kinases*/genetics
Quality of Life*
Humans ; Prospective Studies ; Class I Phosphatidylinositol 3-Kinases/genetics ; Mutation

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Skocz do pozycji: 2.

Tytuł:: Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Autorzy:: Lv Y; Department of Urology, The First Affiliated Hospital of Harbin Medical University, 23 Postal Street, Harbin, 150000, Heilongjiang, China.; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, 150000, Heilongjiang, China.
Liu Z; Department of Urology, The First Affiliated Hospital of Harbin Medical University, 23 Postal Street, Harbin, 150000, Heilongjiang, China.; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, 150000, Heilongjiang, China.
Deng L; Department of Ultrasound Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.
Xia S; Department of Urology, The First Affiliated Hospital of Harbin Medical University, 23 Postal Street, Harbin, 150000, Heilongjiang, China.
Mu Q; Department of Neurosurgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, China.
Xiao B; Department of Urology, The First Affiliated Hospital of Harbin Medical University, 23 Postal Street, Harbin, 150000, Heilongjiang, China.
Xiu Y; Department of Urology, The First Affiliated Hospital of Harbin Medical University, 23 Postal Street, Harbin, 150000, Heilongjiang, China.
Liu Z; Department of Urology, The First Affiliated Hospital of Harbin Medical University, 23 Postal Street, Harbin, 150000, Heilongjiang, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Jan 10; Vol. 14 (1), pp. 1009. Date of Electronic Publication: 2024 Jan 10.
Typ publikacji:: Journal Article
MeSH Terms:: Phosphatidylinositol 3-Kinases*
Urinary Bladder Neoplasms*/drug therapy
Urinary Bladder Neoplasms*/genetics
Hesperidin*
Humans ; Molecular Docking Simulation ; Proto-Oncogene Proteins c-akt ; Network Pharmacology ; Reactive Oxygen Species ; Transcription Factors

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Skocz do pozycji: 3.

Tytuł:: EPYC functions as a novel prognostic biomarker for pancreatic cancer.
Autorzy:: Yang Z; Department of Clinical Laboratory, Tianjin Union Medical Center of Nankai University, Tianjin, China. yangz_.; The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, China. yangz_.
Li H; Department of Clinical Laboratory, Dachuan District People's Hospital, Sichuan, China.
Hao J; Department of Thyroid and Breast Surgery, Tianjin Key Laboratory of General Surgery in Construction, Tianjin Union Medical Center of Nankai University, Tianjin, China.
Mei H; The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, China.; Department of Oncology, Tianjin Union Medical Center of Nankai University, Tianjin, China.
Qiu M; The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, China.; Department of Oncology, Tianjin Union Medical Center of Nankai University, Tianjin, China.
Wang H; The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, China. .; Department of Oncology, Tianjin Union Medical Center of Nankai University, Tianjin, China. .
Gao M; Department of Thyroid and Breast Surgery, Tianjin Key Laboratory of General Surgery in Construction, Tianjin Union Medical Center of Nankai University, Tianjin, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Jan 06; Vol. 14 (1), pp. 719. Date of Electronic Publication: 2024 Jan 06.
Typ publikacji:: Journal Article
MeSH Terms:: Pancreatic Neoplasms*/diagnosis
Pancreatic Neoplasms*/genetics
Phosphatidylinositol 3-Kinases*/genetics
Humans ; Blotting, Western ; Cell Line ; Prognosis

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Skocz do pozycji: 4.

Tytuł:: PI3K/Akt signaling pathway mediates the effect of low-dose boron on barrier function, proliferation and apoptosis in rat intestinal epithelial cells.
Autorzy:: Chen S; College of Animal Science, Anhui Science and Technology University, No. 9, Donghua Road, Fengyang County, Chuzhou City, Anhui Province, China.
Huang J; College of Animal Science, Anhui Science and Technology University, No. 9, Donghua Road, Fengyang County, Chuzhou City, Anhui Province, China.
Liu T; College of Animal Science, Anhui Science and Technology University, No. 9, Donghua Road, Fengyang County, Chuzhou City, Anhui Province, China.
Zhang F; College of Animal Science, Anhui Science and Technology University, No. 9, Donghua Road, Fengyang County, Chuzhou City, Anhui Province, China.
Zhao C; College of Animal Science, Anhui Science and Technology University, No. 9, Donghua Road, Fengyang County, Chuzhou City, Anhui Province, China.
Jin E; College of Animal Science, Anhui Science and Technology University, No. 9, Donghua Road, Fengyang County, Chuzhou City, Anhui Province, China. .; Anhui Province Key Laboratory of Animal Nutritional Regulation and Health, No. 9, Donghua Road, Fengyang County, Chuzhou City, Anhui Province, China. .
Li S; College of Animal Science, Anhui Science and Technology University, No. 9, Donghua Road, Fengyang County, Chuzhou City, Anhui Province, China. .; Anhui Province Key Laboratory of Animal Nutritional Regulation and Health, No. 9, Donghua Road, Fengyang County, Chuzhou City, Anhui Province, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Jan 03; Vol. 14 (1), pp. 393. Date of Electronic Publication: 2024 Jan 03.
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Proteins c-akt*/metabolism
Phosphatidylinositol 3-Kinases*/metabolism
Rats ; Animals ; Caspase 3/metabolism ; Boron/pharmacology ; Boron/metabolism ; Occludin/genetics ; Occludin/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Cell Proliferation ; Signal Transduction ; Epithelial Cells/metabolism ; Apoptosis ; RNA, Messenger/metabolism

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Skocz do pozycji: 5.

Tytuł:: Osteoclast differentiation and dynamic mRNA expression during mice embryonic palatal bone development.
Autorzy:: Lai Y; Department of Oral and Craniomaxillofacial Science, Fujian Medical University Union Hospital, No. 28, Xinquan Road, Fuzhou, 350001, Fujian, China.; Stomatological Key Laboratory of Fujian College and University, Fuzhou, China.
Guo Y; Stomatological Key Laboratory of Fujian College and University, Fuzhou, China.
Liao C; Stomatological Key Laboratory of Fujian College and University, Fuzhou, China.
Mao C; Department of Oral and Craniomaxillofacial Science, Fujian Medical University Union Hospital, No. 28, Xinquan Road, Fuzhou, 350001, Fujian, China.
Liu J; Department of Stomatology, Fujian Maternal and Child Health Hospital, No. 18 Dao Shan Road, Fuzhou, 350001, Fujian, China.
Ren C; Stomatological Key Laboratory of Fujian College and University, Fuzhou, China.
Yang W; Stomatological Key Laboratory of Fujian College and University, Fuzhou, China.
Luo L; Stomatological Key Laboratory of Fujian College and University, Fuzhou, China.
Chen W; Department of Oral and Craniomaxillofacial Science, Fujian Medical University Union Hospital, No. 28, Xinquan Road, Fuzhou, 350001, Fujian, China. .; Stomatological Key Laboratory of Fujian College and University, Fuzhou, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Sep 13; Vol. 13 (1), pp. 15170. Date of Electronic Publication: 2023 Sep 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Osteoclasts*
Phosphatidylinositol 3-Kinases*
Animals ; Mice ; Signal Transduction ; Bone Development/genetics ; RNA, Messenger/genetics

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Skocz do pozycji: 6.

Tytuł:: Association of physical activity with increased PI3K and Akt mRNA levels in adipose tissues of obese and non-obese adults.
Autorzy:: Montazeri M; Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zarkesh M; Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, PO Box: 19395-4763, Tehran, Iran. .
Zadeh-Vakili A; Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, PO Box: 19395-4763, Tehran, Iran. .
Khalili D; Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Movahedi M; Department of Biochemistry, Faculty of Biological Science, North Tehran Branch, Islamic Azad University, Tehran, Iran.
Khalaj A; Tehran Obesity Treatment Center, Department of Surgery, Shahed University, Tehran, Iran.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jun 07; Vol. 13 (1), pp. 9291. Date of Electronic Publication: 2023 Jun 07.
Typ publikacji:: Journal Article
MeSH Terms:: Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Humans ; Adult ; Aged ; Phosphatidylinositol 3-Kinase/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Cross-Sectional Studies ; Obesity/metabolism ; Adipose Tissue/metabolism ; Subcutaneous Fat/metabolism ; Intra-Abdominal Fat/metabolism

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Skocz do pozycji: 7.

Tytuł:: Breviscapine regulates the proliferation, migration, invasion, and apoptosis of colorectal cancer cells via the PI3K/AKT pathway.
Autorzy:: Niu P; Department of Gastrointestinal Surgery, Peking University Shougang Hospital, No. 9, Jinyuanzhuang Road, The Shijingshan District, Beijing, 100144, China.
Liu F; Beijing Viewsolid Biotechnology Co., Ltd., Beijing, 100195, China.
Lei F; Department of Gastrointestinal Surgery, Peking University Shougang Hospital, No. 9, Jinyuanzhuang Road, The Shijingshan District, Beijing, 100144, China.
Peng J; Department of Traditional Chinese Medicine, Peking University Shougang Hospital, Beijing, 100144, China.
Wang Y; Department of Gastrointestinal Surgery, Peking University Shougang Hospital, No. 9, Jinyuanzhuang Road, The Shijingshan District, Beijing, 100144, China.
Zhao J; Department of Traditional Chinese Medicine, Peking University Shougang Hospital, Beijing, 100144, China.
Gao Z; Department of Gastrointestinal Surgery, Peking University Shougang Hospital, No. 9, Jinyuanzhuang Road, The Shijingshan District, Beijing, 100144, China.
Gao Q; Department of Gastrointestinal Surgery, Peking University Shougang Hospital, No. 9, Jinyuanzhuang Road, The Shijingshan District, Beijing, 100144, China.
Gu J; Department of Gastrointestinal Surgery, Peking University Shougang Hospital, No. 9, Jinyuanzhuang Road, The Shijingshan District, Beijing, 100144, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jun 14; Vol. 13 (1), pp. 9674. Date of Electronic Publication: 2023 Jun 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Phosphatidylinositol 3-Kinases*
Colorectal Neoplasms*
Animals ; Mice ; Proto-Oncogene Proteins c-akt ; Mice, Nude ; Neoplastic Processes ; Apoptosis ; Cell Proliferation

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Skocz do pozycji: 8.

Tytuł:: MicroRNA-203a inhibits breast cancer progression through the PI3K/Akt and Wnt pathways.
Autorzy:: Entezari M; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 14115-111, Iran.
Soltani BM; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 14115-111, Iran.
Sadeghizadeh M; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 14115-111, Iran. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Feb 27; Vol. 14 (1), pp. 4715. Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:: Journal Article
MeSH Terms:: MicroRNAs*/metabolism
Breast Neoplasms*/genetics
Humans ; Female ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Wnt Signaling Pathway/genetics ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Cell Line, Tumor ; Neoplastic Processes ; Biomarkers ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic

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Skocz do pozycji: 9.

Tytuł:: HIF-2α-dependent TGFBI promotes ovarian cancer chemoresistance by activating PI3K/Akt pathway to inhibit apoptosis and facilitate DNA repair process.
Autorzy:: Ma S; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Wang J; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Cui Z; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Yang X; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Cui X; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Li X; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Zhao L; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China. .; Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China. .; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China. .; Precision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Feb 16; Vol. 14 (1), pp. 3870. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*/genetics
Drug Resistance, Neoplasm*/genetics
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/pathology
Female ; Humans ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Cisplatin/pharmacology ; DNA Repair ; Hypoxia ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Tumor Microenvironment

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Skocz do pozycji: 10.

Tytuł:: Highlighting the effects of high-intensity interval training on the changes associated with hypertrophy, apoptosis, and histological proteins of the heart of old rats with type 2 diabetes.
Autorzy:: Rami M; Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran. .
Ahmadi Hekmatikar A; Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, 10600, Iran.
Rahdar S; Department of Basic Sciences, Histology Section, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Marashi SS; Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Daud DMA; Health Through Exercise and Active Living (HEAL) Research Unit, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, 88400, Sabah, Malaysia. .; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Malaysia Sabah, Jalan UMS, Kota Kinabalu, 88450, Sabah, Malaysia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Mar 26; Vol. 14 (1), pp. 7133. Date of Electronic Publication: 2024 Mar 26.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus, Type 2*
High-Intensity Interval Training*/methods
Cardiovascular Diseases*
Humans ; Rats ; Animals ; Aged ; Insulin-Like Growth Factor I ; Proto-Oncogene Proteins c-akt ; Myocytes, Cardiac ; Apoptosis ; Fibrosis ; Hypertrophy ; Phosphatidylinositol 3-Kinases

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Skocz do pozycji: 11.

Tytuł:: Screening and identification of lncRNAs in preadipocyte differentiation in sheep.
Autorzy:: Hao Z; Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Jin X; Academic Animal & Veterinary Science, Qinghai University, Xining, China.
Hickford JGH; Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.; Gene-Marker Laboratory, Faculty of Agriculture and Life Science, Lincoln University, Lincoln, 7647, New Zealand.
Zhou H; Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.; Gene-Marker Laboratory, Faculty of Agriculture and Life Science, Lincoln University, Lincoln, 7647, New Zealand.
Wang L; Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Wang J; Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China. .
Luo Y; Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Hu J; Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Liu X; Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Li S; Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Li M; Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Shi B; Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Ren C; Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Mar 04; Vol. 14 (1), pp. 5260. Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:: Journal Article
MeSH Terms:: RNA, Long Noncoding*/genetics
Animals ; Sheep/genetics ; Phosphatidylinositol 3-Kinases ; Mitogen-Activated Protein Kinases ; Phosphatidylinositol 3-Kinase ; RNA-Seq

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Skocz do pozycji: 12.

Tytuł:: The role of leptin in regulation of the soluble amyloid precursor protein α (sAPPα) levels in lung cancer cell media.
Autorzy:: Haddad B; Chemistry Department, Eastern Michigan University, Ypsilanti, MI, 48197, USA.
Khalil J; Chemistry Department, Eastern Michigan University, Ypsilanti, MI, 48197, USA.
Al Khashali H; Chemistry Department, Eastern Michigan University, Ypsilanti, MI, 48197, USA.
Ray R; Chemistry Department, Eastern Michigan University, Ypsilanti, MI, 48197, USA.
Goel S; Chemistry Department, Eastern Michigan University, Ypsilanti, MI, 48197, USA.
Darweesh B; Chemistry Department, Eastern Michigan University, Ypsilanti, MI, 48197, USA.
Coleman KL; Chemistry Department, Eastern Michigan University, Ypsilanti, MI, 48197, USA.
Wozniak C; Chemistry Department, Eastern Michigan University, Ypsilanti, MI, 48197, USA.
Ranzenberger R; Chemistry Department, Eastern Michigan University, Ypsilanti, MI, 48197, USA.
Lopo B; Chemistry Department, Eastern Michigan University, Ypsilanti, MI, 48197, USA.
Guthrie J; Chemistry Department, Eastern Michigan University, Ypsilanti, MI, 48197, USA.
Heyl D; Chemistry Department, Eastern Michigan University, Ypsilanti, MI, 48197, USA.
Evans HG; Chemistry Department, Eastern Michigan University, Ypsilanti, MI, 48197, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Feb 28; Vol. 14 (1), pp. 4921. Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:: Journal Article
MeSH Terms:: Amyloid beta-Protein Precursor*/genetics
Amyloid beta-Protein Precursor*/metabolism
Lung Neoplasms*
Humans ; Leptin/metabolism ; Acetylcholinesterase/metabolism ; Tumor Suppressor Protein p53/genetics ; Phosphatidylinositol 3-Kinases/metabolism

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Skocz do pozycji: 13.

Tytuł:: Bioinformatics analysis for the identification of Sprouty-related EVH1 domain-containing protein 3 expression and its clinical significance in thyroid carcinoma.
Autorzy:: Zhang X; Department of Orthopedics, Zibo Central Hospital, No 54, Gong Qing Tuan Xi Road, Zibo, 255036, People's Republic of China.
Meng X; Department of Drug Clinical Trials, Zibo Central Hospital, Zibo, People's Republic of China.
Wang P; Department of Orthopedics, Zibo Central Hospital, No 54, Gong Qing Tuan Xi Road, Zibo, 255036, People's Republic of China.
Luan C; Department of Orthopedics, Zibo Central Hospital, No 54, Gong Qing Tuan Xi Road, Zibo, 255036, People's Republic of China. .
Wang H; Department of thyroid and breast surgery, Zibo Municipal Hospital, Zibo, 255400, People's Republic of China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Feb 24; Vol. 14 (1), pp. 4549. Date of Electronic Publication: 2024 Feb 24.
Typ publikacji:: Journal Article
MeSH Terms:: Clinical Relevance*
Thyroid Neoplasms*/genetics
Humans ; Biomarkers ; Ligands ; Phosphatidylinositol 3-Kinases ; Prognosis ; Tumor Microenvironment

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Skocz do pozycji: 14.

Tytuł:: PDGFBB facilitates tumorigenesis and malignancy of lung adenocarcinoma associated with PI3K-AKT/MAPK signaling.
Autorzy:: Xiu-Ying H; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.; Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Yue-Xiang Z; School of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, China.
Hui-Si Y; School of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, China.
Hong-Zhou Y; Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Qing-Jie X; Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. .
Ting-Hua W; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China. wangth_.; Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. wangth_.; Laboratory Zoology Department, Institute of Neuroscience, Kunming Medical University, Kunming, China. wangth_.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Feb 20; Vol. 14 (1), pp. 4191. Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:: Journal Article
MeSH Terms:: Lung Neoplasms*/pathology
Adenocarcinoma of Lung*/pathology
Humans ; Becaplermin/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Cell Transformation, Neoplastic/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Cell Movement/genetics ; Cell Line, Tumor

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Skocz do pozycji: 15.

Tytuł:: Transcriptomic analysis of the cerebral hippocampal tissue in spontaneously hypertensive rats exposed to acute hypobaric hypoxia: associations with inflammation and energy metabolism.
Autorzy:: Chang W; Center for Aerospace Clinical Medicine, Department of Aerospace Medicine, Air Force Medical University, Xi'an, 710032, China.
Cui J; Department of Military Medical Equipment and Metrology, School of Military Biomedical Engineering, Air Force Medical University, Xi'an, 710032, China.
Li Y; Center for Aerospace Clinical Medicine, Department of Aerospace Medicine, Air Force Medical University, Xi'an, 710032, China.
Zang K; Center for Aerospace Clinical Medicine, Department of Aerospace Medicine, Air Force Medical University, Xi'an, 710032, China.
Zhang X; Center for Aerospace Clinical Medicine, Department of Aerospace Medicine, Air Force Medical University, Xi'an, 710032, China.
Zhang Z; Center for Aerospace Clinical Medicine, Department of Aerospace Medicine, Air Force Medical University, Xi'an, 710032, China.
Jiang Y; Center for Aerospace Clinical Medicine, Department of Aerospace Medicine, Air Force Medical University, Xi'an, 710032, China.
Ma Q; The College of Life Sciences, Northwest University, Xi'an 710069, China.
Qu S; Center for Aerospace Clinical Medicine, Department of Aerospace Medicine, Air Force Medical University, Xi'an, 710032, China.
Liu F; Center for Aerospace Clinical Medicine, Department of Aerospace Medicine, Air Force Medical University, Xi'an, 710032, China. .; Department of Aviation Medicine, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China. .
Xue J; Center for Aerospace Clinical Medicine, Department of Aerospace Medicine, Air Force Medical University, Xi'an, 710032, China. .; Department of Aviation Medicine, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Mar 06; Vol. 13 (1), pp. 3681. Date of Electronic Publication: 2023 Mar 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Phosphatidylinositol 3-Kinases*
Transcriptome*
Male ; Rats ; Animals ; Rats, Inbred SHR ; Energy Metabolism ; Hippocampus ; Inflammation/genetics ; Hypoxia/genetics

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Skocz do pozycji: 16.

Tytuł:: Acquired radioresistance in EMT6 mouse mammary carcinoma cell line is mediated by CTLA-4 and PD-1 through JAK/STAT/PI3K pathway.
Autorzy:: Sham NFR; Faculty of Medicine, Jalan Hospital, Universiti Teknologi MARA, Selangor Branch, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia.
Hasani NAH; Faculty of Medicine, Jalan Hospital, Universiti Teknologi MARA, Selangor Branch, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia.
Hasan N; Faculty of Dentistry, Jalan Hospital, Universiti Teknologi MARA, Selangor Branch, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia.
Karim MKA; Faculty of Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Fuad SBSA; Faculty of Medicine, Jalan Hospital, Universiti Teknologi MARA, Selangor Branch, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia.
Hasbullah HH; Faculty of Medicine, Jalan Hospital, Universiti Teknologi MARA, Selangor Branch, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia.
Ibahim MJ; Faculty of Medicine, Jalan Hospital, Universiti Teknologi MARA, Selangor Branch, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Feb 22; Vol. 13 (1), pp. 3108. Date of Electronic Publication: 2023 Feb 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: CTLA-4 Antigen*
Phosphatidylinositol 3-Kinases*
Programmed Cell Death 1 Receptor*
Radiation Tolerance*/genetics
Breast Neoplasms*
Animals ; Mice ; Cell Line, Tumor

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Skocz do pozycji: 17.

Tytuł:: SETD5 regulates the OGT-catalyzed O-GlcNAcylation of RNA polymerase II, which is involved in the stemness of colorectal cancer cells.
Autorzy:: Cho HI; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.; Initiative for Biological Function & Systems, Yonsei University, Seoul, 03722, Republic of Korea.
Jo S; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.; Initiative for Biological Function & Systems, Yonsei University, Seoul, 03722, Republic of Korea.
Kim MS; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Kim HB; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.; Department of Neurology, Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
Liu X; Department of Pathology, Yanbian University College of Medicine, No.977, Gongyuan Road, Yanji, 133002, China.
Xuan Y; Department of Pathology, Yanbian University College of Medicine, No.977, Gongyuan Road, Yanji, 133002, China. .
Cho JW; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. .; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. .
Jang YK; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. .; Initiative for Biological Function & Systems, Yonsei University, Seoul, 03722, Republic of Korea. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Nov 14; Vol. 13 (1), pp. 19885. Date of Electronic Publication: 2023 Nov 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: RNA Polymerase II*/genetics
RNA Polymerase II*/metabolism
Colorectal Neoplasms*/genetics
Humans ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; N-Acetylglucosaminyltransferases/metabolism ; Catalysis ; Protein Processing, Post-Translational ; Methyltransferases/metabolism

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Skocz do pozycji: 18.

Tytuł:: Maternal diet induces persistent DNA methylation changes in the muscle of beef calves.
Autorzy:: Amorín R; University of Florida Genetics Institute, University of Florida, Gainesville, FL, 32611, USA.
Liu L; Department of Animal and Dairy Sciences, University of Wisconsin-Madison, 1675 Observatory Dr., Madison, WI, 53706, USA.
Moriel P; Range Cattle Research and Education Center, University of Florida, Ona, FL, 33865, USA.
DiLorenzo N; North Florida Research and Education Center, University of Florida, Marianna, FL, 32351, USA.
Lancaster PA; Department of Clinical Sciences, Kansas State University, Manhattan, KS, 66506, USA.
Peñagaricano F; Department of Animal and Dairy Sciences, University of Wisconsin-Madison, 1675 Observatory Dr., Madison, WI, 53706, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jan 28; Vol. 13 (1), pp. 1587. Date of Electronic Publication: 2023 Jan 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: DNA Methylation*
Phosphatidylinositol 3-Kinases*
Pregnancy ; Female ; Cattle ; Animals ; Male ; Epigenesis, Genetic ; Diet/veterinary ; Muscles ; Methionine ; CpG Islands

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Skocz do pozycji: 19.

Tytuł:: PIK3CA is recurrently mutated in canine mammary tumors, similarly to in human mammary neoplasia.
Autorzy:: Arendt ML; Department of Veterinary Clinical Sciences, University of Copenhagen, Copenhagen, Denmark. .; Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden. .
Sakthikumar S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Melin M; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Clinical Genomics Uppsala, Uppsala University, Uppsala, Sweden.
Elvers I; Karolinska Hospital, Stockholm, Sweden.
Rivera P; Vettris Sundsvall, Sundsvall, Sweden.
Larsen M; Evidensia Specialist Hospital, Helsingborg, Sweden.
Saellström S; Swedish University of Agricultural Sciences, Uppsala, Sweden.
Lingaas F; Veterinary Faculty, Norwegian University of Life Sciences, Ås, Norway.
Rönnberg H; Swedish University of Agricultural Sciences, Uppsala, Sweden.
Lindblad-Toh K; Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden. .; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jan 12; Vol. 13 (1), pp. 632. Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Class I Phosphatidylinositol 3-Kinases*/genetics
Mammary Neoplasms, Animal*/genetics
Animals ; Dogs ; Female ; Humans ; Breast Neoplasms/genetics ; Mutation, Missense ; Proto-Oncogene Proteins p21(ras)/genetics

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Skocz do pozycji: 20.

Tytuł:: Transcriptional regulation of Notch1 by nuclear factor-κB during T cell activation.
Autorzy:: Hwang JR; Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea.
Kim D; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea.
Kang JA; Bio-Nanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Park SH; Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Park SG; Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jan 02; Vol. 13 (1), pp. 43. Date of Electronic Publication: 2023 Jan 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: NF-kappa B*/metabolism
Phosphatidylinositol 3-Kinases*/metabolism
Gene Expression Regulation ; Transcription Factor RelA/metabolism ; T-Lymphocytes/metabolism ; Transcriptional Activation ; Receptor, Notch1/genetics ; Receptor, Notch1/metabolism ; RNA, Messenger/metabolism

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