Temat: "Phosphoenolpyruvate Carboxykinase \(GTP\)" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Expanding the clinical spectrum of cytosolic phosphoenolpyruvate carboxykinase deficiency: novel PCK1 variants in four Arabian Gulf families.
Autorzy:: Al Busaidi M; College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Mohamed FE; Genetics and Genomics Department, College of Medicine and Health Sciences, United Arab Emirates University, P. O. Box 1555, Al Ain, United Arab Emirates.; ASPIRE Precision Medicine Research Institute Abu Dhabi, United Arab Emirates University, Al Ain, United Arab Emirates.
Al-Ajmi E; Department of Radiology and Molecular Imaging, Sultan Qaboos University Hospital, Muscat, Oman.
Al Hashmi N; Department of Pediatrics, The Royal Hospital, Muscat, Oman.
Al-Thihli K; Department of Genetic and Developmental Medicine Clinic, Sultan Qaboos University Hospital, P.O. Box 38, Muscat, Alkoudh, 123, Oman.
Al Futaisi A; Department of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Al Mamari W; Department of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Al-Murshedi F; Department of Genetic and Developmental Medicine Clinic, Sultan Qaboos University Hospital, P.O. Box 38, Muscat, Alkoudh, 123, Oman. .
Al-Jasmi F; Genetics and Genomics Department, College of Medicine and Health Sciences, United Arab Emirates University, P. O. Box 1555, Al Ain, United Arab Emirates. .; ASPIRE Precision Medicine Research Institute Abu Dhabi, United Arab Emirates University, Al Ain, United Arab Emirates. .; Department of Pediatrics, Tawam Hospital, Al Ain, United Arab Emirates. .; Pokaż więcej
Źródło:: Orphanet journal of rare diseases [Orphanet J Rare Dis] 2023 Nov 03; Vol. 18 (1), pp. 344. Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:: Journal Article
MeSH Terms:: Brain Diseases*
Hypoglycemia*/etiology
Intracellular Signaling Peptides and Proteins*/genetics
Liver Diseases*/complications
Phosphoenolpyruvate Carboxykinase (GTP)*/genetics
Humans ; Infant, Newborn ; Seizures/genetics
SCR Disease Name:: Phosphoenolpyruvate carboxykinase deficiency

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Skocz do pozycji: 2.

Tytuł:: hnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner.
Autorzy:: Hao W; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Chen Z; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Tang J; Department of Ultrasound, Fudan University Shanghai Cancer Center, Shanghai, China.
Yang R; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Gao WQ; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. .; Med-X Research Institute and School of Biological Medical Engineering, Shanghai Jiao Tong University, Shanghai, China. .
Xu H; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. .; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2023 Nov 28; Vol. 21 (1), pp. 861. Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/pathology
Animals ; Humans ; Mice ; Carcinogenesis/genetics ; Cell Line, Tumor ; Intracellular Signaling Peptides and Proteins/metabolism ; Methylation ; Phosphoenolpyruvate Carboxykinase (GTP)/genetics ; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism ; RNA/metabolism ; RNA, Guide, CRISPR-Cas Systems ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics

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Skocz do pozycji: 3.

Tytuł:: Serum anti-PCK1 antibody levels are a prognostic factor for patients with diabetes mellitus.
Autorzy:: Namiki T; Department of Diabetes, Metabolism and Endocrinology, School of Medicine, International University of Health and Welfare, Narita Hospital, 852 Hatakeda, Narita City, Chiba, 286-8520, Japan.
Takemoto M; Department of Diabetes, Metabolism and Endocrinology, School of Medicine, International University of Health and Welfare, Narita Hospital, 852 Hatakeda, Narita City, Chiba, 286-8520, Japan. .
Hayashi A; Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Yamagata H; Department of Diabetes, Metabolism and Endocrinology, School of Medicine, International University of Health and Welfare, Narita Hospital, 852 Hatakeda, Narita City, Chiba, 286-8520, Japan.
Ishikawa T; Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Yokote K; Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Li SY; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Kubota M; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Zhang BS; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Yoshida Y; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Matsutani T; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Mine S; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.; Department of Neurological Surgery, Chiba Prefectural Sawara Hospital, Chiba, 287-0003, Japan.; Department of Neurological Surgery, Chiba Cerebral and Cardiovascular Center, Chiba, 290-0512, Japan.
Machida T; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.; Department of Neurological Surgery, Chiba Cerebral and Cardiovascular Center, Chiba, 290-0512, Japan.; Department of Neurosurgery, Eastern Chiba Medical Center, Chiba, 283-8686, Japan.
Kobayashi Y; Department of Cardiovascular Medicine, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Terada J; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Naito A; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Tatsumi K; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Takizawa H; Port Square Kashiwado Clinic, Kashiwado Memorial Foundation, Chiba, 260-0025, Japan.
Nakamura R; Medical Project Division, Research Development Center, Fujikura Kasei Co, Saitama, 340-0203, Japan.
Kuroda H; Medical Project Division, Research Development Center, Fujikura Kasei Co, Saitama, 340-0203, Japan.
Iwadate Y; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Hiwasa T; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.; Pokaż więcej
Źródło:: BMC endocrine disorders [BMC Endocr Disord] 2023 Oct 30; Vol. 23 (1), pp. 239. Date of Electronic Publication: 2023 Oct 30.
Typ publikacji:: Journal Article
MeSH Terms:: Ischemic Stroke*
Diabetes Mellitus*/diagnosis
Atherosclerosis*
Humans ; DNA, Complementary ; Prognosis ; Autoantibodies ; Recombinant Proteins ; Phosphoenolpyruvate Carboxykinase (GTP) ; Intracellular Signaling Peptides and Proteins

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Skocz do pozycji: 4.

Tytuł:: Suppression of SLC39A6-CREB1 axis in liver cancer causes PCK1-mediated mitochondrial dysfunction.
Autorzy:: Yu Z; Department of General Surgery, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, China.; The Laboratory of Cytobiology and Molecular Biology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, China.; The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Chen C; Department of Oncology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Gu H; Department of General Surgery, Zhoushan Hospital, Zhejiang University School of Medicine, Zhoushan, Zhejiang, China.
Dong J; Department of General Surgery, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, China.
Zhang Y; Department of General Surgery, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, China.
Wang J; The Laboratory of Cytobiology and Molecular Biology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, China.
Ma H; The Laboratory of Cytobiology and Molecular Biology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, China.
Zhang G; Department of General Surgery, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, China.; The Laboratory of Cytobiology and Molecular Biology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, China.; Pokaż więcej
Źródło:: Cell proliferation [Cell Prolif] 2023 Oct; Vol. 56 (10), pp. e13527. Date of Electronic Publication: 2023 Jul 12.
Typ publikacji:: Letter
MeSH Terms:: Liver Neoplasms*/genetics
Cation Transport Proteins*
Humans ; Mitochondria/metabolism ; Neoplasm Proteins ; Cyclic AMP Response Element-Binding Protein ; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism ; Intracellular Signaling Peptides and Proteins

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Skocz do pozycji: 5.

Tytuł:: Differential expression of gluconeogenesis-related transcripts in a freshwater zooplankton model organism suggests a role of the Cori cycle in hypoxia tolerance.
Autorzy:: Malek MC; Department of Biological Sciences, East Tennessee State University, Johnson City, Tennessee, United States of America.
Behera JR; Department of Biological Sciences, East Tennessee State University, Johnson City, Tennessee, United States of America.
Kilaru A; Department of Biological Sciences, East Tennessee State University, Johnson City, Tennessee, United States of America.
Yampolsky LY; Department of Biological Sciences, East Tennessee State University, Johnson City, Tennessee, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Aug 08; Vol. 18 (8), pp. e0284679. Date of Electronic Publication: 2023 Aug 08 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gluconeogenesis*/genetics
Zooplankton*/metabolism
Animals ; Caenorhabditis elegans/metabolism ; NAD/metabolism ; Phosphoenolpyruvate Carboxykinase (GTP)/genetics ; Glucose/metabolism ; Hypoxia/genetics ; Aquatic Organisms/metabolism ; Fresh Water ; Adenosine Triphosphate/metabolism

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Skocz do pozycji: 6.

Tytuł:: Comparative transcriptome analysis reveals that PCK1 is a potential gene affecting IMF deposition in buffalo.
Autorzy:: Huang J; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, 530005, Guangxi, China. .; College of Life Sciences, Xinyang Normal University, Xinyang, 464000, Henan, China. .
Feng X; College of Life Sciences, Xinyang Normal University, Xinyang, 464000, Henan, China.
Zhu R; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, 530005, Guangxi, China.
Guo D; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, 530005, Guangxi, China.
Wei Y; College of Life Sciences, Xinyang Normal University, Xinyang, 464000, Henan, China.
Cao X; College of Life Sciences, Xinyang Normal University, Xinyang, 464000, Henan, China.
Ma Y; College of Life Sciences, Xinyang Normal University, Xinyang, 464000, Henan, China.; School of Agriculture, Ningxia University, Yinchuan, 750021, Ningxia, China.
Shi D; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, 530005, Guangxi, China.; Pokaż więcej
Źródło:: BMC genomics [BMC Genomics] 2020 Oct 12; Vol. 21 (1), pp. 710. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji:: Journal Article
MeSH Terms:: Adipose Tissue*/metabolism
Buffaloes*/genetics
Phosphoenolpyruvate Carboxykinase (GTP)*/genetics
Transcriptome*
Animals ; Cattle ; Cells, Cultured ; China ; Gene Expression Profiling ; Mice ; Muscle, Skeletal/metabolism

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Skocz do pozycji: 7.

Tytuł:: PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27 axis.
Autorzy:: Tuo L; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
Xiang J; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
Pan X; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
Hu J; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
Tang H; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
Liang L; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
Xia J; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
Hu Y; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
Zhang W; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
Huang A; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China. .
Wang K; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China. .
Tang N; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China. .; Pokaż więcej
Źródło:: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 Feb 04; Vol. 38 (1), pp. 50. Date of Electronic Publication: 2019 Feb 04.
Typ publikacji:: Journal Article
MeSH Terms:: AMP-Activated Protein Kinases/*metabolism
Calcium-Binding Proteins/*metabolism
Carcinoma, Hepatocellular/*pathology
G1 Phase Cell Cycle Checkpoints/*physiology
Intracellular Signaling Peptides and Proteins/*metabolism
Liver Neoplasms/*pathology
Phosphoenolpyruvate Carboxykinase (GTP)/*metabolism
AMP-Activated Protein Kinases/genetics ; Animals ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Cyclin-Dependent Kinases/metabolism ; Down-Regulation ; E2F Transcription Factors/metabolism ; G1 Phase Cell Cycle Checkpoints/drug effects ; G1 Phase Cell Cycle Checkpoints/genetics ; Gene Knockdown Techniques ; Glucose/metabolism ; Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Intracellular Signaling Peptides and Proteins/genetics ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Male ; Metformin/pharmacology ; Metformin/therapeutic use ; Mice ; Phosphoenolpyruvate Carboxykinase (GTP)/genetics ; Up-Regulation ; Xenograft Model Antitumor Assays

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Skocz do pozycji: 8.

Tytuł:: Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells.
Autorzy:: Doubleday PF; Department of Molecular Biosciences and Chemistry, Northwestern University, Evanston, IL, USA.
Fornelli L; Department of Biology, Department of Biology, University of Oklahoma, Norman, OK, USA.
Ntai I; Thermo Fisher Scientific, San Jose, CA, USA.
Kelleher NL; Department of Molecular Biosciences and Chemistry, Northwestern University, Evanston, IL, USA.; Pokaż więcej
Źródło:: The FEBS journal [FEBS J] 2021 Dec; Vol. 288 (23), pp. 6683-6699. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Mutation*
Aspartic Acid/*genetics
Colorectal Neoplasms/*genetics
Proto-Oncogene Proteins p21(ras)/*genetics
Signal Transduction/*genetics
Argininosuccinate Synthase/genetics ; Argininosuccinate Synthase/metabolism ; Aspartic Acid/metabolism ; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor/genetics ; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor/metabolism ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Gene Expression Profiling/methods ; Gene Ontology ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Metabolomics/methods ; Phosphoenolpyruvate Carboxykinase (ATP)/genetics ; Phosphoenolpyruvate Carboxykinase (ATP)/metabolism ; Phosphoenolpyruvate Carboxykinase (GTP)/genetics ; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism ; Proteomics/methods ; Proto-Oncogene Proteins p21(ras)/metabolism

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Skocz do pozycji: 9.

Tytuł:: Growth hormone promotes hepatic gluconeogenesis by enhancing BTG2-YY1 signaling pathway.
Autorzy:: Jo JR; Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, 41566, Republic of Korea.
An S; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Ghosh S; Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Nedumaran B; Barbara Davis Center for Diabetes, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Kim YD; Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, 41566, Republic of Korea. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Sep 23; Vol. 11 (1), pp. 18999. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gluconeogenesis/*genetics
Growth Hormone/*metabolism
Immediate-Early Proteins/*metabolism
Tumor Suppressor Proteins/*metabolism
YY1 Transcription Factor/*metabolism
Animals ; Cell Line ; Glucose/biosynthesis ; Glucose-6-Phosphatase/genetics ; Glucose-6-Phosphatase/metabolism ; Growth Hormone/administration & dosage ; Hepatocytes ; Humans ; Injections, Intraperitoneal ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Liver/metabolism ; Male ; Mice ; Models, Animal ; Phosphoenolpyruvate Carboxykinase (GTP)/genetics ; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism ; Point Mutation ; Primary Cell Culture ; Promoter Regions, Genetic ; Signal Transduction/genetics

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Skocz do pozycji: 10.

Tytuł:: Case report: composite pancreatic intraductal papillary mucinous neoplasm and neuroendocrine tumor: a new mixed neuroendocrine-non-neuroendocrine neoplasm?
Autorzy:: Chen J; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Wang P; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Lv K; Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Zhou W; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. .; Pokaż więcej
Źródło:: Diagnostic pathology [Diagn Pathol] 2021 Nov 20; Vol. 16 (1), pp. 108. Date of Electronic Publication: 2021 Nov 20.
Typ publikacji:: Case Reports; Journal Article; Review
MeSH Terms:: Carcinoma, Neuroendocrine/*pathology
Neoplasms, Complex and Mixed/*pathology
Pancreatic Intraductal Neoplasms/*pathology
Pancreatic Neoplasms/*pathology
Biomarkers, Tumor/genetics ; Carcinoma, Neuroendocrine/genetics ; Carcinoma, Neuroendocrine/surgery ; Cell Differentiation ; DNA Mutational Analysis ; DNA-Binding Proteins/genetics ; Genetic Predisposition to Disease ; High-Throughput Nucleotide Sequencing ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Male ; Middle Aged ; Mutation ; Neoplasms, Complex and Mixed/genetics ; Neoplasms, Complex and Mixed/surgery ; Pancreatectomy ; Pancreatic Intraductal Neoplasms/genetics ; Pancreatic Intraductal Neoplasms/surgery ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/surgery ; Phenotype ; Phosphoenolpyruvate Carboxykinase (GTP)/genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; Treatment Outcome

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Skocz do pozycji: 11.

Tytuł:: O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α.
Autorzy:: Latorre P; Departamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain.; Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), BIFIIQFR (CSIC) Joint Unit, Universidad de Zaragoza, Zaragoza, Spain.
Varona L; Departamento de Anatomía, Embriología y Genética, Universidad de Zaragoza, Zaragoza, Spain.; Instituto Agroalimentario de Aragón (IA2), Zaragoza, Spain.
Burgos C; Departamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain.; Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), BIFIIQFR (CSIC) Joint Unit, Universidad de Zaragoza, Zaragoza, Spain.
Carrodeguas JA; Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), BIFIIQFR (CSIC) Joint Unit, Universidad de Zaragoza, Zaragoza, Spain.; Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain.; IIS Aragón, Zaragoza, Spain.
López-Buesa P; Departamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain.; Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), BIFIIQFR (CSIC) Joint Unit, Universidad de Zaragoza, Zaragoza, Spain.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2017 Jun 23; Vol. 12 (6), pp. e0179988. Date of Electronic Publication: 2017 Jun 23 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*metabolism
Phosphoenolpyruvate Carboxykinase (GTP)/*metabolism
Amino Acid Sequence ; Animals ; Epistasis, Genetic ; Glucose/metabolism ; Glycosylation ; HEK293 Cells ; Hep G2 Cells ; Humans ; PPAR gamma/metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Phenotype ; Phosphoenolpyruvate Carboxykinase (GTP)/genetics ; Protein Processing, Post-Translational ; Protein Stability ; RNA, Messenger/metabolism ; Sequence Homology, Amino Acid ; Swine

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Skocz do pozycji: 12.

Tytuł:: Gentiopicroside and sweroside from Veratrilla baillonii Franch. induce phosphorylation of Akt and suppress Pck1 expression in hepatoma cells.
Autorzy:: Huang XJ; a College of Pharmacy, South-Central University for Nationalities, Wuhan, P.R. China.
Li J; a College of Pharmacy, South-Central University for Nationalities, Wuhan, P.R. China.
Mei ZY; a College of Pharmacy, South-Central University for Nationalities, Wuhan, P.R. China.
Chen G; b Department of Nutrition, University of Tennessee at Knoxville, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996, USA.; Pokaż więcej
Źródło:: Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2016 Jun; Vol. 94 (3), pp. 270-8. Date of Electronic Publication: 2016 Feb 18.
Typ publikacji:: Journal Article
MeSH Terms:: Gentianales/*chemistry
Intracellular Signaling Peptides and Proteins/*metabolism
Iridoid Glucosides/*pharmacology
Phosphoenolpyruvate Carboxykinase (GTP)/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Animals ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Chromatography, High Pressure Liquid ; Dose-Response Relationship, Drug ; Insulin/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Liver Neoplasms/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Phosphoenolpyruvate Carboxykinase (GTP)/genetics ; Phosphorylation/drug effects ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plants, Medicinal/chemistry ; RNA, Messenger ; Rats

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Skocz do pozycji: 13.

Tytuł:: c.A2456C-substitution in Pck1 changes the enzyme kinetic and functional properties modifying fat distribution in pigs.
Autorzy:: Latorre P; Departamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain.; Instituto de Biocomputación y Física de Sistemas Complejos, Universidad de Zaragoza, 50018 Zaragoza, Spain.
Burgos C; Departamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain.; Instituto de Biocomputación y Física de Sistemas Complejos, Universidad de Zaragoza, 50018 Zaragoza, Spain.
Hidalgo J; Departamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain.; Instituto de Biocomputación y Física de Sistemas Complejos, Universidad de Zaragoza, 50018 Zaragoza, Spain.
Varona L; Instituto de Biocomputación y Física de Sistemas Complejos, Universidad de Zaragoza, 50018 Zaragoza, Spain.; Departamento de Anatomía, Embriología y Genética, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain.
Carrodeguas JA; Instituto de Biocomputación y Física de Sistemas Complejos, Universidad de Zaragoza, 50018 Zaragoza, Spain.; Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain.; IIS Aragón, 50009 Zaragoza, Spain.
López-Buesa P; Departamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain.; Instituto de Biocomputación y Física de Sistemas Complejos, Universidad de Zaragoza, 50018 Zaragoza, Spain.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2016 Jan 21; Vol. 6, pp. 19617. Date of Electronic Publication: 2016 Jan 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alleles*
Amino Acid Substitution*
Polymorphism, Single Nucleotide*
Adiposity/*genetics
Phosphoenolpyruvate Carboxykinase (GTP)/*genetics
Phosphoenolpyruvate Carboxykinase (GTP)/*metabolism
Acetylation ; Amino Acid Sequence ; Animals ; Breeding ; Cell Line ; Enzyme Activation ; Enzyme Stability ; Gene Frequency ; Humans ; Isoenzymes ; Kinetics ; Lipogenesis/genetics ; Models, Molecular ; Phenotype ; Phosphoenolpyruvate Carboxykinase (GTP)/chemistry ; Protein Conformation ; Quantitative Trait, Heritable ; Sequence Analysis, DNA ; Substrate Specificity ; Swine ; Temperature

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 14.

Tytuł:: The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells.
Autorzy:: Brearley MC; School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK.; Department of Medicine-Cardiology, University of California, Los Angeles, CA, USA.
Daniel ZCTR; School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK.
Loughna PT; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK.
Parr T; School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK.
Brameld JM; School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Dec 17; Vol. 10 (1), pp. 22177. Date of Electronic Publication: 2020 Dec 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Differentiation/*drug effects
Enzyme Inhibitors/*pharmacology
Muscle Development/*drug effects
Phosphoenolpyruvate Carboxykinase (ATP)/*antagonists & inhibitors
Phosphoenolpyruvate Carboxykinase (GTP)/*antagonists & inhibitors
Picolinic Acids/*pharmacology
Animals ; Biomarkers ; Cell Line ; Cell Proliferation/drug effects ; Cells, Cultured ; Gene Expression Regulation/drug effects ; Gluconeogenesis/genetics ; Isoenzymes ; Mice ; Muscle Cells ; Promoter Regions, Genetic ; RNA, Messenger/genetics ; Serine/biosynthesis

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Pełny tekst Szczegóły

Skocz do pozycji: 15.

Tytuł:: Crocins from Crocus sativus L. in the Management of Hyperglycemia. In Vivo Evidence from Zebrafish.
Autorzy:: Kakouri E; Laboratory of Chemistry, Department of Food Science & Human Nutrition, School of Food and Nutritional Sciences, Agricultural University of Athens, 111855 Athens, Greece.
Agalou A; Developmental Biology, Biomedical Research Foundation Academy of Athens, 11527 Athens, Greece.
Kanakis C; Laboratory of Chemistry, Department of Food Science & Human Nutrition, School of Food and Nutritional Sciences, Agricultural University of Athens, 111855 Athens, Greece.
Beis D; Developmental Biology, Biomedical Research Foundation Academy of Athens, 11527 Athens, Greece.
Tarantilis PA; Laboratory of Chemistry, Department of Food Science & Human Nutrition, School of Food and Nutritional Sciences, Agricultural University of Athens, 111855 Athens, Greece.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 Nov 10; Vol. 25 (22). Date of Electronic Publication: 2020 Nov 10.
Typ publikacji:: Journal Article
MeSH Terms:: Carotenoids/*pharmacology
Crocus/*chemistry
Hyperglycemia/*drug therapy
Animals ; Animals, Genetically Modified ; Blood Glucose/metabolism ; Carotenoids/analysis ; Gluconeogenesis ; Glucose/metabolism ; Insulin/metabolism ; Insulin-Secreting Cells/metabolism ; Ions ; Pancreas/embryology ; Pancreas/metabolism ; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism ; Plant Extracts/pharmacology ; Zebrafish

Czasopismo naukowe

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Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 16.

Tytuł:: Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring.
Autorzy:: Inoguchi Y; Division of Epigenomics and Development, Department of Molecular and Structural Biology Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. .; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. .
Ichiyanagi K; Division of Epigenomics and Development, Department of Molecular and Structural Biology Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.; Laboratory of Genome and Epigenome Dynamics, Department of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan.
Ohishi H; Division of Epigenomics and Development, Department of Molecular and Structural Biology Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Maeda Y; Clinical Research Center for Diabetes, Clinic Masae Minami, Fukuoka, Japan.
Sonoda N; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ogawa Y; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Department of Molecular and Cellular Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.; AMED-CREST, Japan Agency for Medical Research and Development, Tokyo, Japan.
Inoguchi T; Fukuoka Health Promotion Support Center, Fukuoka, Japan.
Sasaki H; Division of Epigenomics and Development, Department of Molecular and Structural Biology Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Jul 15; Vol. 9 (1), pp. 10181. Date of Electronic Publication: 2019 Jul 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Diabetes Mellitus, Experimental/*metabolism
Forkhead Box Protein O1/*metabolism
Glucose Intolerance/*etiology
Animals ; Blood Glucose/metabolism ; Diabetes, Gestational/metabolism ; Female ; Forkhead Box Protein O1/physiology ; Gluconeogenesis/genetics ; Glucose Intolerance/metabolism ; Glucose-6-Phosphatase/metabolism ; Insulin/metabolism ; Insulin-Secreting Cells/metabolism ; Lactation/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism ; Pregnancy ; Streptozocin/pharmacology