Temat: "Phospholipases A2, Cytosolic" - OpacWWW

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Tytuł:: The effects of myelin on macrophage activation are phenotypic specific via cPLA 2 in the context of spinal cord injury inflammation.
Autorzy:: Kopper TJ; Department of Physiology, Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
Zhang B; Department of Physiology, Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
Bailey WM; Department of Physiology, Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
Bethel KE; Department of Physiology, Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
Gensel JC; Department of Physiology, Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Mar 18; Vol. 11 (1), pp. 6341. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Inflammation/*genetics
Myelin Sheath/*genetics
Phospholipases A2, Cytosolic/*genetics
Spinal Cord Injuries/*genetics
Animals ; Cytokines/biosynthesis ; Cytokines/genetics ; Disease Models, Animal ; Female ; Humans ; Inflammation/pathology ; Interleukin-4/biosynthesis ; Ketones/pharmacology ; Lipids/biosynthesis ; Lipids/genetics ; Macrophage Activation/genetics ; Mice ; Microglia/metabolism ; Microglia/pathology ; Nitric Oxide/biosynthesis ; Phagocytosis/genetics ; Phenotype ; Phospholipases A2, Cytosolic/antagonists & inhibitors ; Reactive Oxygen Species/metabolism ; Spinal Cord Injuries/pathology

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Tytuł:: Inhibition of sPLA₂-IIA prevents LPS-induced neuroinflammation by suppressing ERK1/2-cPLA₂α pathway in mice cerebral cortex.
Autorzy:: Xiang Y; Department of Pharmacology, Shandong University School of Medicine, Jinan, Shandong, PR China.
Chen L
Liu H
Liu X
Wei X
Sun B
Wang T
Zhang X; Pokaż więcej
Źródło:: PloS one [PLoS One] 2013 Oct 09; Vol. 8 (10), pp. e77909. Date of Electronic Publication: 2013 Oct 09 (Print Publication: 2013).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cerebral Cortex/*drug effects
Enzyme Inhibitors/*pharmacology
Group II Phospholipases A2/*antagonists & inhibitors
Inflammation/*prevention & control
MAP Kinase Signaling System/*drug effects
Phospholipases A2, Cytosolic/*antagonists & inhibitors
Animals ; Astrocytes/drug effects ; Astrocytes/immunology ; Cells, Cultured ; Cerebral Cortex/enzymology ; Cerebral Cortex/immunology ; Group II Phospholipases A2/immunology ; Inflammation/enzymology ; Inflammation/immunology ; Lipopolysaccharides/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Phospholipases A2, Cytosolic/immunology ; Rats ; Rats, Wistar

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