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Wyszukujesz frazę ""Phosphoproteins"" wg kryterium: Temat


Tytuł :
Phosphorylation of the conserved C-terminal domain of ribosomal P-proteins impairs the mode of interaction with plant toxins.
Autorzy :
Horbowicz-Drożdżal P; Department of Molecular Biology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Lublin, Poland.
Kamel K; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Kmiecik S; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Poland.
Borkiewicz L; Department of Biochemistry and Molecular Biology, Medical University of Lublin, Poland.
Tumer NE; Department of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, USA.
Shaw PC; School of Life Sciences, The Chinese University of Hong Kong, China.
Tchórzewski M; Department of Molecular Biology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Lublin, Poland.
Grela P; Department of Molecular Biology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Lublin, Poland.
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Źródło :
FEBS letters [FEBS Lett] 2021 Sep; Vol. 595 (17), pp. 2221-2236. Date of Electronic Publication: 2021 Aug 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Phosphoproteins/*chemistry
Phosphoproteins/*metabolism
Ribosomal Proteins/*chemistry
Ribosomal Proteins/*metabolism
Toxins, Biological/*metabolism
Glutamic Acid/metabolism ; Humans ; Molecular Docking Simulation ; Phosphoproteins/genetics ; Phosphorylation ; Protein Domains ; Ribosomal Proteins/genetics ; Ricin/chemistry ; Ricin/metabolism ; Serine/metabolism ; Toxins, Biological/chemistry ; Trichosanthin/chemistry ; Trichosanthin/metabolism
Czasopismo naukowe
Tytuł :
The molecular basis of Rac-GTP action-promoting binding of p67 to Nox2 by disengaging the β hairpin from downstream residues.
Autorzy :
Bechor E; The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Zahavi A; The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Berdichevsky Y; The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Pick E; The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Aug; Vol. 110 (2), pp. 219-237. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
NADPH Oxidase 2/*metabolism
Phosphoproteins/*metabolism
rac GTP-Binding Proteins/*metabolism
Binding Sites ; Mutation ; NADPH Oxidase 2/chemistry ; NADPH Oxidase 2/genetics ; NADPH Oxidases/chemistry ; NADPH Oxidases/metabolism ; Peptides/chemistry ; Peptides/metabolism ; Phosphoproteins/chemistry ; Phosphoproteins/genetics ; Protein Binding ; Protein Interaction Domains and Motifs ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Targeting-YAP/TAZ therapies for head and neck cancer, directly or indirectly?
Autorzy :
Feng XD; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
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Źródło :
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology [Hua Xi Kou Qiang Yi Xue Za Zhi] 2021 Oct 01; Vol. 39 (5), pp. 493-500.
Typ publikacji :
Journal Article
MeSH Terms :
Head and Neck Neoplasms*
Phosphoproteins*/metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Humans ; Trans-Activators/metabolism ; Transcription Factors
Czasopismo naukowe
Tytuł :
Circ_0020093 ameliorates IL-1β-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b.
Autorzy :
Feng M; Department of Orthopaedics, Xuanwu Hospital, Capital Medical University, Changchun Ave 45, Xicheng District, Beijing, 100053, China. .
Jing L; Department of Orthopaedics, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Cheng J; Department of Orthopaedics, Xuanwu Hospital, Capital Medical University, Changchun Ave 45, Xicheng District, Beijing, 100053, China.
An S; Department of Orthopaedics, Xuanwu Hospital, Capital Medical University, Changchun Ave 45, Xicheng District, Beijing, 100053, China.
Huang J; Department of Orthopaedics, Xuanwu Hospital, Capital Medical University, Changchun Ave 45, Xicheng District, Beijing, 100053, China.
Yan Q; Department of Orthopaedics, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Oct; Vol. 476 (10), pp. 3623-3633. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Chondrocytes/*metabolism
Extracellular Matrix/*metabolism
Interleukin-1beta/*pharmacology
Membrane Proteins/*biosynthesis
Phosphoproteins/*biosynthesis
RNA, Circular/*metabolism
Up-Regulation/*drug effects
Apoptosis/genetics ; Extracellular Matrix/genetics ; Humans ; Membrane Proteins/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Phosphoproteins/genetics ; RNA, Circular/genetics
Czasopismo naukowe
Tytuł :
Characterization of the aberrant splicing of MAP3K7 induced by cancer-associated SF3B1 mutation.
Autorzy :
Li Z; Laboratory of Cancer Biology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin 130033, China.; School of Life Sciences, Jilin University, Changchun, Jilin 130012, China.
Zhao B; Laboratory of Cancer Biology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin 130033, China.; School of Life Sciences, Jilin University, Changchun, Jilin 130012, China.
Shi Y; Laboratory of Cancer Biology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin 130033, China.; School of Life Sciences, Jilin University, Changchun, Jilin 130012, China.
Liang Y; School of Life Sciences, Jilin University, Changchun, Jilin 130012, China.
Qian R; Laboratory of Cancer Biology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin 130033, China.; School of Life Sciences, Jilin University, Changchun, Jilin 130012, China.
Wan Y; Laboratory of Cancer Biology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin 130033, China.
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Źródło :
Journal of biochemistry [J Biochem] 2021 Sep 22; Vol. 170 (1), pp. 69-77.
Typ publikacji :
Journal Article
MeSH Terms :
MAP Kinase Kinase Kinases/*genetics
Neoplasms/*genetics
Phosphoproteins/*genetics
RNA Splicing/*genetics
RNA Splicing Factors/*genetics
Cells, Cultured ; HEK293 Cells ; Humans ; MAP Kinase Kinase Kinases/metabolism ; Mutation ; Neoplasms/metabolism ; Phosphoproteins/metabolism ; RNA Splicing Factors/metabolism
Czasopismo naukowe
Tytuł :
Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall.
Autorzy :
Ortega MA; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.; Ramón y Cajal Institute of Healthcare Research (IRYCIS), Madrid, Spain.; Cancer Registry and Pathology Department, Hospital Universitario Principe de Asturias, Alcalá de Henares, Madrid, Spain.
Fraile-Martínez O; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.
García-Montero C; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.
Ruiz-Grande F; Angiology and Vascular Surgery Service, Hospital Universitario Principe de Asturias, Alcalá de Henares, Madrid, Spain.; Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.
Barrena S; Angiology and Vascular Surgery Service, Hospital Universitario Principe de Asturias, Alcalá de Henares, Madrid, Spain.
Montoya H; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.
Pekarek L; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.
Zoullas S; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.
Alvarez-Mon MA; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.
Sainz F; Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.; Angiology and Vascular Surgery Service, Central University Hospital of Defence-UAH Madrid, Spain.
Asúnsolo A; Ramón y Cajal Institute of Healthcare Research (IRYCIS), Madrid, Spain.; Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.
Acero J; Ramón y Cajal Institute of Healthcare Research (IRYCIS), Madrid, Spain.; Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.
Álvarez-Mon M; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.; Ramón y Cajal Institute of Healthcare Research (IRYCIS), Madrid, Spain.; Immune System Diseases-Rheumatology, Oncology Service and Internal Medicine (CIBEREHD), University Hospital Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
Buján J; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.; Ramón y Cajal Institute of Healthcare Research (IRYCIS), Madrid, Spain.
García-Honduvilla N; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.; Ramón y Cajal Institute of Healthcare Research (IRYCIS), Madrid, Spain.
Guijarro LG; Ramón y Cajal Institute of Healthcare Research (IRYCIS), Madrid, Spain.; Unit of Biochemistry and Molecular Biology (CIBEREHD), Department of System Biology, University of Alcalá, Alcalá de Henares, Spain.
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Źródło :
The Journal of international medical research [J Int Med Res] 2021 Sep; Vol. 49 (9), pp. 3000605211041275.
Typ publikacji :
Journal Article
MeSH Terms :
Phosphoproteins*/metabolism
Saphenous Vein*
Adaptor Proteins, Signal Transducing ; Humans ; Insulin Receptor Substrate Proteins ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Phenotypic variability of a TREX1 variant in Aicardi-Goutieres type 1 patients from the Indian subcontinent.
Autorzy :
Abraham SSC; Department of Clinical Genetics, Christian Medical College, Vellore, Tamil Nadu, India.
Yoganathan S; Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Koshy B; Department of Developmental Pediatrics, Christian Medical College, Vellore, Tamil Nadu, India.
Oommen SP; Department of Developmental Pediatrics, Christian Medical College, Vellore, Tamil Nadu, India.
Simon A; Department of Child Health, Christian Medical College, Vellore, Tamil Nadu, India.
Mathai S; Department of Child Health, Christian Medical College, Vellore, Tamil Nadu, India.
Korula S; Department of Child Health, Christian Medical College, Vellore, Tamil Nadu, India.
Mathew L; Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India.
Sathishkumar D; Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India.
Jasper A; Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.
George R; Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India.
Danda S; Department of Clinical Genetics, Christian Medical College, Vellore, Tamil Nadu, India. Electronic address: .
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Źródło :
European journal of medical genetics [Eur J Med Genet] 2021 Sep; Vol. 64 (9), pp. 104291. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Phenotype*
Autoimmune Diseases of the Nervous System/*genetics
Exodeoxyribonucleases/*genetics
Nervous System Malformations/*genetics
Phosphoproteins/*genetics
Autoimmune Diseases of the Nervous System/epidemiology ; Autoimmune Diseases of the Nervous System/pathology ; Exodeoxyribonucleases/chemistry ; Female ; Founder Effect ; Gene Frequency ; Humans ; India ; Infant ; Male ; Mutation ; Nervous System Malformations/epidemiology ; Nervous System Malformations/pathology ; Phosphoproteins/chemistry ; Protein Domains
SCR Disease Name :
Aicardi-Goutieres syndrome
Czasopismo naukowe
Tytuł :
Treacle and TOPBP1 control replication stress response in the nucleolus.
Autorzy :
Velichko AK; Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia.; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russia.
Ovsyannikova N; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Petrova NV; Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia.
Luzhin AV; Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia.
Vorobjeva M; Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia.
Gavrikov AS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, Moscow, Russia.
Mishin AS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, Moscow, Russia.
Kireev II; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.; V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Moscow, Russia.
Razin SV; Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia.
Kantidze OL; Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia.
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Źródło :
The Journal of cell biology [J Cell Biol] 2021 Aug 02; Vol. 220 (8). Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
DNA Replication*
Carrier Proteins/*metabolism
Cell Nucleolus/*metabolism
DNA, Ribosomal/*biosynthesis
DNA-Binding Proteins/*metabolism
Nuclear Proteins/*metabolism
Phosphoproteins/*metabolism
Aphidicolin/pharmacology ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Carrier Proteins/genetics ; Cell Nucleolus/drug effects ; Cell Nucleolus/genetics ; DNA, Ribosomal/genetics ; DNA-Binding Proteins/genetics ; Genomic Instability ; HCT116 Cells ; HeLa Cells ; Humans ; Hydroxyurea/pharmacology ; Microscopy, Fluorescence ; Nuclear Proteins/genetics ; Phosphoproteins/genetics ; Protein Binding ; Protein Transport ; Signal Transduction
Czasopismo naukowe
Tytuł :
Mn -Phos-Tag Polyacrylamide for the Quantification of Protein Phosphorylation Levels.
Autorzy :
Markandran K; Laboratory of Muscle and Cardiac Biophysics, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Xuan JVLE; Laboratory of Muscle and Cardiac Biophysics, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Yu H; Laboratory of Muscle and Cardiac Biophysics, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; WuXi Biologics, Wuxi, Jiangsu, China.
Shun LM; Laboratory of Muscle and Cardiac Biophysics, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Ferenczi MA; Laboratory of Muscle and Cardiac Biophysics, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Brunel Medical School, Brunel University London, Uxbridge, UK.
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Źródło :
Current protocols [Curr Protoc] 2021 Aug; Vol. 1 (8), pp. e221.
Typ publikacji :
Journal Article
MeSH Terms :
Phosphoproteins*/metabolism
Acrylic Resins ; Electrophoresis, Polyacrylamide Gel ; Humans ; Phosphorylation ; Pyridines
Czasopismo naukowe
Tytuł :
Starting-NOX2-Up: Rac unrolls p67 .
Autorzy :
El-Benna J; Université de Paris, INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation (CRI), Laboratoire d'Excellence Inflamex, Faculté de Médecine Xavier Bichat, Paris, France.
Dang PM; Université de Paris, INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation (CRI), Laboratoire d'Excellence Inflamex, Faculté de Médecine Xavier Bichat, Paris, France.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Aug; Vol. 110 (2), pp. 213-215. Date of Electronic Publication: 2021 May 16.
Typ publikacji :
Editorial; Comment
MeSH Terms :
NADPH Oxidases*
Phosphoproteins*
Humans ; Oxazoles ; Phagocytes
Opinia redakcyjna
Tytuł :
IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.
Autorzy :
Jiang Z; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.
Wei F; College of Agriculture, Ningxia University, Yinchuan, China. .
Zhang Y; School of Biological Science and Technology, University of Jinan, Jinan, China.
Wang T; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.
Gao W; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.
Yu S; College of Agriculture, Ningxia University, Yinchuan, China.
Sun H; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.
Pu J; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.
Sun Y; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.
Wang M; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.
Tong Q; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.
Gao C; Key Laboratory of Infection and Immunity of Shandong Province and Department of Immunology, School of Biomedical Sciences, Shandong University, Jinan, China.
Chang KC; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Sutton Bonington, UK.
Liu J; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China. .
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Źródło :
Nature microbiology [Nat Microbiol] 2021 Jul; Vol. 6 (7), pp. 932-945. Date of Electronic Publication: 2021 May 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DEAD Box Protein 58/*genetics
Influenza A virus/*physiology
Nuclear Proteins/*metabolism
Orthomyxoviridae Infections/*virology
Phosphoproteins/*metabolism
RNA, Viral/*metabolism
Receptors, Immunologic/*genetics
Animals ; DEAD Box Protein 58/metabolism ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Interferon Type I/metabolism ; Mice ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/metabolism ; Phosphoproteins/chemistry ; Phosphoproteins/genetics ; Promoter Regions, Genetic ; Protein Binding ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Receptors, Immunologic/metabolism ; Signal Transduction ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT Cells by Downregulating PSIP1 and NUCKS1.
Autorzy :
Zhang C; Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Li J; Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Guo Y; Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Wang R; Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Hua L; Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Gan D; Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Zhu L; Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Ma P; Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Yang J; Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Li H; Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Li S; Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Song Y; Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China .
Su H; Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China .
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Źródło :
Annals of clinical and laboratory science [Ann Clin Lab Sci] 2021 Jul; Vol. 51 (4), pp. 470-486.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Adaptor Proteins, Signal Transducing/*antagonists & inhibitors
Biomarkers, Tumor/*metabolism
Nuclear Proteins/*antagonists & inhibitors
Phosphoproteins/*antagonists & inhibitors
Skin Neoplasms/*pathology
Transcription Factors/*antagonists & inhibitors
Transcription Factors/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Aged ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Movement ; Cell Proliferation ; Female ; HaCaT Cells ; Humans ; Male ; Neoplasm Invasiveness ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Prognosis ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism ; Survival Rate ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Systemic lupus erythematosus overlapping dermatomyositis owing to a heterozygous TREX1 Asp130Asn missense mutation.
Autorzy :
Endo Y; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Medical Sciences, Nagasaki, Japan.
Koga T; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Medical Sciences, Nagasaki, Japan. Electronic address: .
Otaki H; Center for Bioinformatics and Molecular Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Furukawa K; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Medical Sciences, Nagasaki, Japan.
Kawakami A; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Medical Sciences, Nagasaki, Japan.
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Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2021 Jun; Vol. 227, pp. 108732. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Dermatomyositis/*genetics
Exodeoxyribonucleases/*genetics
Lupus Erythematosus, Systemic/*genetics
Phosphoproteins/*genetics
Adult ; Antigens, Surface/genetics ; DNA/metabolism ; DNA/ultrastructure ; Dermatomyositis/metabolism ; Dermatomyositis/physiopathology ; Exodeoxyribonucleases/metabolism ; Exodeoxyribonucleases/ultrastructure ; GPI-Linked Proteins/genetics ; Heterozygote ; Humans ; Interferon Type I ; Interferon-alpha/metabolism ; Lupus Erythematosus, Systemic/metabolism ; Lupus Erythematosus, Systemic/physiopathology ; Male ; Molecular Docking Simulation ; Mutation, Missense ; Myxovirus Resistance Proteins/genetics ; Phosphoproteins/metabolism ; Phosphoproteins/ultrastructure ; Transcriptome ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł :
Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors.
Autorzy :
Luise C; Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Kurt-Mothes-Str.3, 06120 Halle/Saale, Germany.
Robaa D; Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Kurt-Mothes-Str.3, 06120 Halle/Saale, Germany.
Regenass P; Institute for Organic Chemistry, University of Freiburg, Albertstr. 21, 79104 Freiburg, Germany.
Maurer D; Institute for Organic Chemistry, University of Freiburg, Albertstr. 21, 79104 Freiburg, Germany.
Ostrovskyi D; Institute for Organic Chemistry, University of Freiburg, Albertstr. 21, 79104 Freiburg, Germany.
Seifert L; Institute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104 Freiburg, Germany.
Bacher J; Institute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104 Freiburg, Germany.
Burgahn T; Institute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104 Freiburg, Germany.
Wagner T; Institute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104 Freiburg, Germany.
Seitz J; Institute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104 Freiburg, Germany.
Greschik H; Department of Urology and Center for Clinical Research, University Freiburg Medical Center, Breisacherstr. 66, 79106 Freiburg, Germany.
Park KS; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Xiong Y; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jin J; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Schüle R; Department of Urology and Center for Clinical Research, University Freiburg Medical Center, Breisacherstr. 66, 79106 Freiburg, Germany.
Breit B; Institute for Organic Chemistry, University of Freiburg, Albertstr. 21, 79104 Freiburg, Germany.
Jung M; Institute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104 Freiburg, Germany.; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
Sippl W; Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Kurt-Mothes-Str.3, 06120 Halle/Saale, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 31; Vol. 22 (11). Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article
MeSH Terms :
Biophysical Phenomena*
Epigenesis, Genetic*
Protein Conformation*
Cell Cycle Proteins/*chemistry
Microtubule-Associated Proteins/*chemistry
Phosphoproteins/*chemistry
Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/ultrastructure ; Entropy ; Humans ; Microtubule-Associated Proteins/antagonists & inhibitors ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/ultrastructure ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Phosphoproteins/antagonists & inhibitors ; Phosphoproteins/genetics ; Phosphoproteins/ultrastructure ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Quartz crystal microbalance sensor based on 11-mercaptoundecanoic acid self-assembly and amidated nano-titanium film for selective and ultrafast detection of phosphoproteins in food.
Autorzy :
Guo J; Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science & Technology, 29 The Thirteenth Road, Tianjin Economy and Technology Development Area, Tianjin 300457, PR China.
Fang G; Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science & Technology, 29 The Thirteenth Road, Tianjin Economy and Technology Development Area, Tianjin 300457, PR China.
Wang S; Medical College, Nankai University, No.38 Tongyan Road, Jinnan District, Tianjin 300350, PR China.
Wang J; Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science & Technology, 29 The Thirteenth Road, Tianjin Economy and Technology Development Area, Tianjin 300457, PR China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 May 15; Vol. 344, pp. 128656. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article
MeSH Terms :
Fatty Acids/*chemistry
Food Analysis/*instrumentation
Nanostructures/*chemistry
Phosphoproteins/*analysis
Quartz Crystal Microbalance Techniques/*instrumentation
Sulfhydryl Compounds/*chemistry
Titanium/*chemistry
Electrodes ; Phosphoproteins/chemistry ; Time Factors
Czasopismo naukowe
Tytuł :
Distinct bone marrow immunophenotypic features define the splicing factor 3B subunit 1 (SF3B1)-mutant myelodysplastic syndromes subtype.
Autorzy :
Duetz C; Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Location VUmc, Amsterdam, the Netherlands.
Westers TM; Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Location VUmc, Amsterdam, the Netherlands.
In 't Hout FEM; Laboratory of Hematology, Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.
Cremers EMP; Department of Hematology, Maastricht University Medical Center, Maastricht, the Netherlands.
Alhan C; Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Location VUmc, Amsterdam, the Netherlands.
Venniker-Punt B; Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Location VUmc, Amsterdam, the Netherlands.
Visser-Wisselaar HA; Department of Hematology, HOVON Data Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Chitu DA; Department of Hematology, HOVON Data Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
de Graaf AO; Laboratory of Hematology, Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.
Smit L; Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Location VUmc, Amsterdam, the Netherlands.
Jansen JH; Laboratory of Hematology, Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.
van de Loosdrecht AA; Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Location VUmc, Amsterdam, the Netherlands.
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Źródło :
British journal of haematology [Br J Haematol] 2021 May; Vol. 193 (4), pp. 798-803. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosomes, Human, Pair 5*/genetics
Chromosomes, Human, Pair 5*/immunology
Gene Deletion*
Immunophenotyping*
Myelodysplastic Syndromes*/classification
Myelodysplastic Syndromes*/genetics
Myelodysplastic Syndromes*/immunology
Phosphoproteins*/genetics
Phosphoproteins*/immunology
RNA Splicing Factors*/genetics
RNA Splicing Factors*/immunology
Bone Marrow Cells/*immunology
Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
Nitrous anhydrase activity of carbonic anhydrase II: cysteine is required for nitric oxide (NO) dependent phosphorylation of VASP in human platelets.
Autorzy :
Tsikas D; Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, Hannover, Germany.
Gambaryan S; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Petersburg, Russia.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 525-534.
Typ publikacji :
Journal Article
MeSH Terms :
Blood Platelets/*metabolism
Carbonic Anhydrase II/*metabolism
Cell Adhesion Molecules/*metabolism
Cysteine/*metabolism
Microfilament Proteins/*metabolism
Nitric Oxide/*metabolism
Nitrite Reductases/*metabolism
Phosphoproteins/*metabolism
Blood Platelets/chemistry ; Carbonic Anhydrase II/chemistry ; Cell Adhesion Molecules/chemistry ; Cysteine/chemistry ; Humans ; Microfilament Proteins/chemistry ; Nitric Oxide/chemistry ; Nitrite Reductases/chemistry ; Oxidoreductases ; Phosphoproteins/chemistry ; Phosphorylation
Czasopismo naukowe
Tytuł :
The extensive and functionally uncharacterized mitochondrial phosphoproteome.
Autorzy :
Niemi NM; Department of Biochemistry & Molecular Biophysics, Washington University in St Louis, St Louis, Missouri, USA.
Pagliarini DJ; Departments of Cell Biology and Physiology, Biochemistry & Molecular Biophysics, and Genetics, Washington University in St Louis, St Louis, Missouri, USA; Morgridge Institute for Research, Madison, Wisconsin, USA; Department of Biochemistry, University of Madison-Wisconsin, Madison, Wisconsin, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jul; Vol. 297 (1), pp. 100880. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mitochondrial Proteins/*metabolism
Phosphoproteins/*metabolism
Proteome/*metabolism
Animals ; Humans ; Mitochondrial Proteins/genetics ; Phosphoprotein Phosphatases/genetics ; Phosphoprotein Phosphatases/metabolism ; Phosphoproteins/genetics ; Phosphorylation ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Proteome/genetics
Czasopismo naukowe
Tytuł :
Endosomal cAMP production broadly impacts the cellular phosphoproteome.
Autorzy :
Tsvetanova NG; Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA; Department of Psychiatry, University of California San Francisco, San Francisco, California, USA. Electronic address: .
Trester-Zedlitz M; Department of Psychiatry, University of California San Francisco, San Francisco, California, USA.
Newton BW; Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, California, USA.
Peng GE; Program in Cell Biology, University of California San Francisco, San Francisco, California, USA.
Johnson JR; Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, California, USA; Microbiology Department, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jimenez-Morales D; Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, California, USA; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford University, Stanford, California, USA.
Kurland AP; Microbiology Department, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Krogan NJ; Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, California, USA; J. David Gladstone Institute, San Francisco, California, USA.
von Zastrow M; Department of Psychiatry, University of California San Francisco, San Francisco, California, USA; Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jul; Vol. 297 (1), pp. 100907. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cyclic AMP/*metabolism
Endosomes/*metabolism
Phosphoproteins/*metabolism
Proteome/*metabolism
Animals ; HEK293 Cells ; Humans ; Phosphoproteins/chemistry ; Phosphorylation ; Protein Domains ; Protein Phosphatase 2/metabolism ; Proteome/chemistry
Czasopismo naukowe
Tytuł :
MEX3A promotes development and progression of breast cancer through regulation of PIK3CA.
Autorzy :
Shi X; Department of General Surgery, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Sun Y; School of Medicine, Southeast University, Nanjing, China.
Zhang Y; Department of General Surgery, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Wang W; Department of General Surgery, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Xu J; Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China.
Guan Y; School of Medicine, Southeast University, Nanjing, China.
Ding Y; Department of General Surgery, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: .
Yao Y; Department of General Surgery, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Jul 01; Vol. 404 (1), pp. 112580. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*metabolism
Cell Proliferation/*physiology
Class I Phosphatidylinositol 3-Kinases/*metabolism
Gene Expression Regulation, Neoplastic/*genetics
Phosphoproteins/*metabolism
RNA-Binding Proteins/*metabolism
Breast Neoplasms/genetics ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Line, Tumor ; Cell Movement/physiology ; Class I Phosphatidylinositol 3-Kinases/genetics ; Female ; Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoproteins/genetics ; RNA-Binding Proteins/genetics
Czasopismo naukowe

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