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Wyszukujesz frazę ""Phosphorylation"" wg kryterium: Temat


Tytuł:
Enhanced oxidative phosphorylation, re-organized intracellular signaling, and epigenetic de-silencing as revealed by oligodendrocyte translatome analysis after contusive spinal cord injury.
Autorzy:
Forston MD; Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, 40202, USA.; Department of Anatomical Sciences & Neurobiology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Wei GZ; Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, 40202, USA.; Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.; MD/PhD Program, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Chariker JH; Kentucky IDeA Networks of Biomedical Research Excellence (KY INBRE) Bioinformatics Core, University of Louisville, Louisville, KY, 40202, USA.; Neuroscience Training, University Louisville School of Medicine, Louisville, KY, 40202, USA.
Stephenson T; Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, 40202, USA.; Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Andres K; Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, 40202, USA.; Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Glover C; Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, 40202, USA.; Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Rouchka EC; Kentucky IDeA Networks of Biomedical Research Excellence (KY INBRE) Bioinformatics Core, University of Louisville, Louisville, KY, 40202, USA.; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Whittemore SR; Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, 40202, USA.; Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, KY, 40202, USA.; Department of Anatomical Sciences & Neurobiology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.; Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.; MD/PhD Program, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Hetman M; Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, 40202, USA. .; Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, KY, 40202, USA. .; Department of Anatomical Sciences & Neurobiology, University of Louisville School of Medicine, Louisville, KY, 40202, USA. .; Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY, 40202, USA. .; MD/PhD Program, University of Louisville School of Medicine, Louisville, KY, 40202, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Dec 01; Vol. 13 (1), pp. 21254. Date of Electronic Publication: 2023 Dec 01.
Typ publikacji:
Journal Article
MeSH Terms:
Oxidative Phosphorylation*
Spinal Cord Injuries*
Mice ; Animals ; Oligodendroglia/metabolism ; Myelin Sheath/metabolism ; Epigenesis, Genetic ; Spinal Cord/metabolism
Czasopismo naukowe
Tytuł:
Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types.
Autorzy:
Boykov IN; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.; East Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, Greenville, NC, 27834, USA.
Montgomery MM; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.; East Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, Greenville, NC, 27834, USA.
Hagen JT; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.; East Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, Greenville, NC, 27834, USA.
Aruleba RT; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.; East Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, Greenville, NC, 27834, USA.
McLaughlin KL; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.; East Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, Greenville, NC, 27834, USA.
Coalson HS; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.; East Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, Greenville, NC, 27834, USA.
Nelson MA; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.; East Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, Greenville, NC, 27834, USA.
Pereyra AS; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.; East Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, Greenville, NC, 27834, USA.
Ellis JM; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.; East Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, Greenville, NC, 27834, USA.
Zeczycki TN; Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Vohra NA; Department of Surgery, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Tan SF; Department of Medicine, Division of Hematology/Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Cabot MC; East Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, Greenville, NC, 27834, USA.; Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Fisher-Wellman KH; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA. .; East Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, Greenville, NC, 27834, USA. .; UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 05; Vol. 13 (1), pp. 16742. Date of Electronic Publication: 2023 Oct 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
MeSH Terms:
Oxidative Phosphorylation*
Neoplasms*/genetics
Neoplasms*/metabolism
Mice ; Humans ; Animals ; Mitochondria/metabolism ; Energy Metabolism
Czasopismo naukowe
Tytuł:
Cysteine protease inhibitor 1 promotes metastasis by mediating an oxidative phosphorylation/MEK/ERK axis in esophageal squamous carcinoma cancer.
Autorzy:
Zhang L; Shengli Clinical Medical College, Fujian Medical University, No.134 East Street, Fuzhou, 350001, Fujian Province, China.; Department of Clinical Laboratory, Fujian Provincial Hospital South Branch, Fuzhou, 350008, Fujian, China.
Chen X; Shengli Clinical Medical College, Fujian Medical University, No.134 East Street, Fuzhou, 350001, Fujian Province, China.; Department of Scientific Research, Fujian Provincial Hospital, Fuzhou, 350001, Fujian, China.
Wang J; Shengli Clinical Medical College, Fujian Medical University, No.134 East Street, Fuzhou, 350001, Fujian Province, China.; Department of Clinical Laboratory, Fujian Provincial Hospital South Branch, Fuzhou, 350008, Fujian, China.
Chen M; Shengli Clinical Medical College, Fujian Medical University, No.134 East Street, Fuzhou, 350001, Fujian Province, China.; Department of Clinical Laboratory, Fujian Provincial Hospital South Branch, Fuzhou, 350008, Fujian, China.
Chen J; Shengli Clinical Medical College, Fujian Medical University, No.134 East Street, Fuzhou, 350001, Fujian Province, China.; Clinical Laboratory Department of Fuding Hospital, Fujian University of Traditional Chinese Medicine, Fuding, 355200, Fujian, China.
Zhuang W; Shengli Clinical Medical College, Fujian Medical University, No.134 East Street, Fuzhou, 350001, Fujian Province, China.; Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, Fujian, China.
Xia Y; Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, Fujian, China.; Integrated Chinese and Western Medicine College, Fujian University of Traditional Chinese Medicine, Fuzhou, 350000, Fujian, China.
Huang Z; Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, Fujian, China.; Integrated Chinese and Western Medicine College, Fujian University of Traditional Chinese Medicine, Fuzhou, 350000, Fujian, China.
Zheng Y; Shengli Clinical Medical College, Fujian Medical University, No.134 East Street, Fuzhou, 350001, Fujian Province, China.; Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, Fujian, China.
Huang Y; Shengli Clinical Medical College, Fujian Medical University, No.134 East Street, Fuzhou, 350001, Fujian Province, China. .; Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, Fujian, China. .; Central Laboratory, Center for Experimental Research in Clinical Medicine, Fujian Provincial Hospital, Fuzhou, 350001, Fujian, China. .; Fujian Provincial Key Laboratory of Critical Care Medicine, Fujian Provincial Key Laboratory of Cardiovascular Disease, Fuzhou, 350001, Fujian, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 29; Vol. 14 (1), pp. 4985. Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
MeSH Terms:
Esophageal Squamous Cell Carcinoma*/metabolism
Esophageal Neoplasms*/pathology
Dipeptides*
Diazomethane/*analogs & derivatives
Humans ; Oxidative Phosphorylation ; Pilot Projects ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Cell Proliferation ; Cell Movement
Czasopismo naukowe
Tytuł:
Synthetic receptor scaffolds significantly affect the efficiency of cell fate signals.
Autorzy:
Umene K; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8656, Japan.
Kawahara M; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8656, Japan. .; Laboratory of Cell Vaccine, Microbial Research Center for Health and Medicine (MRCHM), National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Saito-Asagi, Ibaraki-Shi, Osaka, 567-0085, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 09; Vol. 14 (1), pp. 5801. Date of Electronic Publication: 2024 Mar 09.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, Artificial*/metabolism
Signal Transduction ; Phosphorylation ; Protein-Tyrosine Kinases/metabolism ; Cell Differentiation
Czasopismo naukowe
Tytuł:
Trypanosoma cruzi infection induces DNA double-strand breaks and activates DNA damage response pathway in host epithelial cells.
Autorzy:
Gonzáles-Córdova RA; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil.
Dos Santos TR; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil.
Gachet-Castro C; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil.
Andrade Vieira J; Department of Genetics, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil.
Trajano-Silva LAM; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil.
Sakamoto-Hojo ET; Department of Genetics, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil.; Department of Biology, Faculty of Philosophy Sciences and Letters at Ribeirão Preto, University of São Paulo, São Paulo, 14040-901, Brazil.
Baqui MMA; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 04; Vol. 14 (1), pp. 5225. Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Breaks, Double-Stranded*
Chagas Disease*/genetics
Humans ; Epithelial Cells ; Phosphorylation ; DNA Repair
Czasopismo naukowe
Tytuł:
Hygrothermal stress increases malignant arrhythmias susceptibility by inhibiting the LKB1-AMPK-Cx43 pathway.
Autorzy:
Chi J; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.; Branch of National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Guangzhou, China.; Guangzhou Key Laboratory of Cardiac Rehabilitation, Guangzhou, China.
Wu N; Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Li P; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.
Hu J; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.; School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Cai H; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.; Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Lin C; Branch of National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Guangzhou, China.; School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Lai Y; Branch of National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Guangzhou, China.; School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Yang H; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.
Huang J; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.; Branch of National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Guangzhou, China.
Li M; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.; Branch of National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Guangzhou, China.
Xu L; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China. xxgnk_.; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China. xxgnk_.; Branch of National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Guangzhou, China. xxgnk_.; Guangzhou Key Laboratory of Cardiac Rehabilitation, Guangzhou, China. xxgnk_.
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 29; Vol. 14 (1), pp. 5010. Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
MeSH Terms:
Connexin 43*/metabolism
AMP-Activated Protein Kinases*/metabolism
Rats ; Animals ; Rats, Sprague-Dawley ; Arrhythmias, Cardiac ; Protein Serine-Threonine Kinases/metabolism ; Phosphorylation ; Adenosine Monophosphate/metabolism
Czasopismo naukowe
Tytuł:
Dynamic hydrogen peroxide levels reveal a rate-dependent sensitivity in B-cell lymphoma signaling.
Autorzy:
Witmond M; Institute for Molecules and Materials (IMM), Radboud University Nijmegen, Nijmegen, The Netherlands.
Keizer E; Institute for Molecules and Materials (IMM), Radboud University Nijmegen, Nijmegen, The Netherlands.
Kiffen B; Institute for Molecules and Materials (IMM), Radboud University Nijmegen, Nijmegen, The Netherlands.
Huck WTS; Institute for Molecules and Materials (IMM), Radboud University Nijmegen, Nijmegen, The Netherlands. .
van Buggenum JAGL; Institute for Molecules and Materials (IMM), Radboud University Nijmegen, Nijmegen, The Netherlands. .; Single Cell Discoveries (SCD), Utrecht, The Netherlands. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 21; Vol. 14 (1), pp. 4265. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
Hydrogen Peroxide*
Lymphoma, Large B-Cell, Diffuse*/pathology
Humans ; Signal Transduction ; Phosphorylation ; Receptors, Antigen, B-Cell/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
miR-483-5p orchestrates the initiation of protein synthesis by facilitating the decrease in phosphorylated Ser209eIF4E and 4E-BP1 levels.
Autorzy:
Nagaraj S; Interdisciplinary Laboratory of Molecular Biology and Biophysics, Centre of New Technologies, University of Warsaw, 02-097, Warsaw, Poland.; Laboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Pasteur 3, 02-093, Warsaw, Poland.
Stankiewicz-Drogon A; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093, Warsaw, Poland.
Darzynkiewicz E; Interdisciplinary Laboratory of Molecular Biology and Biophysics, Centre of New Technologies, University of Warsaw, 02-097, Warsaw, Poland.; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093, Warsaw, Poland.
Wojda U; Laboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Pasteur 3, 02-093, Warsaw, Poland. .
Grzela R; Interdisciplinary Laboratory of Molecular Biology and Biophysics, Centre of New Technologies, University of Warsaw, 02-097, Warsaw, Poland. .; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093, Warsaw, Poland. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 20; Vol. 14 (1), pp. 4237. Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Eukaryotic Initiation Factor-4E*/genetics
Eukaryotic Initiation Factor-4E*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Humans ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; HEK293 Cells ; Intracellular Signaling Peptides and Proteins/metabolism ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Serine-Threonine Kinases/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł:
Native PLGA nanoparticles attenuate Aβ-seed induced tau aggregation under in vitro conditions: potential implication in Alzheimer's disease pathology.
Autorzy:
Paul PS; Departments of Medicine (Neurology), Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, T6G 2M8, Canada.
Patel T; Departments of Biochemistry, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, T6G 2M8, Canada.
Cho JY; Nanotechnology Research Centre, National Research Council Canada, Edmonton, AB, T6G 2M9, Canada.
Yarahmady A; Departments of Biochemistry, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, T6G 2M8, Canada.
Khalili A; Nanotechnology Research Centre, National Research Council Canada, Edmonton, AB, T6G 2M9, Canada.
Semenchenko V; Nanotechnology Research Centre, National Research Council Canada, Edmonton, AB, T6G 2M9, Canada.
Wille H; Departments of Biochemistry, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, T6G 2M8, Canada.
Kulka M; Nanotechnology Research Centre, National Research Council Canada, Edmonton, AB, T6G 2M9, Canada.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, T6G 2E1, Canada.
Mok SA; Departments of Biochemistry, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, T6G 2M8, Canada.
Kar S; Departments of Medicine (Neurology), Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, T6G 2M8, Canada. .; Centre for Prions and Protein Folding Diseases, Departments of Medicine (Neurology) and Psychiatry, University of Alberta, Edmonton, AB, T6G 2M8, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 02; Vol. 14 (1), pp. 144. Date of Electronic Publication: 2024 Jan 02.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Nanoparticles*
Aged ; Animals ; Humans ; tau Proteins/metabolism ; Amyloid beta-Peptides/metabolism ; Phosphorylation
Czasopismo naukowe
Tytuł:
Hexose phosphorylation for a non-enzymatic glycolysis and pentose phosphate pathway on early Earth.
Autorzy:
Hirakawa Y; Department of Earth Science, Tohoku University, 6-3, Aza-Aoba, Aramaki, Aoba-Ku, Sendai, 980-8578, Japan. .
Kakegawa T; Department of Earth Science, Tohoku University, 6-3, Aza-Aoba, Aramaki, Aoba-Ku, Sendai, 980-8578, Japan.
Furukawa Y; Department of Earth Science, Tohoku University, 6-3, Aza-Aoba, Aramaki, Aoba-Ku, Sendai, 980-8578, Japan.
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 02; Vol. 14 (1), pp. 264. Date of Electronic Publication: 2024 Jan 02.
Typ publikacji:
Journal Article
MeSH Terms:
Pentose Phosphate Pathway*
Borates*
Phosphorylation ; Glycolysis ; Hexoses ; Glucose/metabolism ; Phosphates
Czasopismo naukowe
Tytuł:
Fluorescence Lifetime Imaging Microscopy (FLIM) reveals spatial-metabolic changes in 3D breast cancer spheroids.
Autorzy:
Karrobi K; Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Tank A; Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Fuzail MA; Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Kalidoss M; Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Tilbury K; Department of Chemical and Biomedical Engineering, University of Maine, Orono, ME, 04469, USA.
Zaman M; Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Ferruzzi J; Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.; Department of Biomedical Engineering, The University of Texas at Dallas, Richardson, TX, 75080, USA.
Roblyer D; Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 03; Vol. 13 (1), pp. 3624. Date of Electronic Publication: 2023 Mar 03.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Oxidative Phosphorylation*
Neoplasms*
Microscopy, Fluorescence ; Signal Transduction ; Cell Line ; Extracellular Matrix ; NAD
Czasopismo naukowe
Tytuł:
Low-dose brain radiation: lowering hyperphosphorylated-tau without increasing DNA damage or oncogenic activation.
Autorzy:
Iacono D; DoD/USU Brain Tissue Repository and Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA. .; Department of Neurology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA. .; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA. .; Neuroscience Program, Department of Anatomy, Physiology and Genetics, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA. .; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, USA. .; Neurodegeneration Disorders Clinic, National Institute of Neurological Disorders and Stroke, NINDS, NIH, Bethesda, MD, USA. .
Murphy EK; DoD/USU Brain Tissue Repository and Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA.; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, USA.
Stimpson CD; DoD/USU Brain Tissue Repository and Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA.; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, USA.
Perl DP; DoD/USU Brain Tissue Repository and Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA.; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA.
Day RM; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA.
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 30; Vol. 13 (1), pp. 21142. Date of Electronic Publication: 2023 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
tau Proteins*/metabolism
Alzheimer Disease*/metabolism
Animals ; Swine ; Brain/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; DNA Damage ; Amyloid beta-Peptides/metabolism ; Phosphorylation ; Mammals/metabolism
Czasopismo naukowe
Tytuł:
Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways.
Autorzy:
Saidy B; Nottingham Breast Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Vasan R; Nottingham Breast Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Durant R; Nottingham Breast Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Greener MR; Nottingham Breast Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Immanuel A; Nottingham Breast Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Green AR; Nottingham Breast Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Rakha E; Nottingham Breast Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Ellis I; Nottingham Breast Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Ball G; Medical Technology Research Centre, Anglia Ruskin University, Bishop Hall Lane, Chelmsford, CM1 1SQ, UK.
Martin SG; Nottingham Breast Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Storr SJ; Nottingham Breast Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 30; Vol. 13 (1), pp. 21163. Date of Electronic Publication: 2023 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/metabolism
Female ; Humans ; Cell Adhesion Molecules/metabolism ; Dopamine and cAMP-Regulated Phosphoprotein 32/metabolism ; Phosphorylation ; Receptor Protein-Tyrosine Kinases/metabolism ; Signal Transduction ; Transcriptome
Czasopismo naukowe
Tytuł:
STAT3 phosphorylation at serine 727 activates specific genetic programs and promotes clear cell renal cell carcinoma (ccRCC) aggressiveness.
Autorzy:
Arévalo J; Renal Physiopathology Group, Vall d'Hebron Research Institute, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain. .
Campoy I; Renal Physiopathology Group, Vall d'Hebron Research Institute, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
Durán M; Renal Physiopathology Group, Vall d'Hebron Research Institute, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
Nemours S; Molecular Oncology Group, Biodonostia Health Research Institute, Paseo Dr. Begiristain, s/n, 20014, San Sebastián, Spain.
Areny A; Renal Physiopathology Group, Vall d'Hebron Research Institute, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
Vall-Palomar M; Renal Physiopathology Group, Vall d'Hebron Research Institute, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
Martínez C; Vascular and Renal Translational Research Group, Lleida Institute for Biomedical Research Dr. Pifarré Foundation (IRBLleida), Av. Alcalde Rovira Roure, 80, 25198, Lleida, Spain.
Cantero-Recasens G; Renal Physiopathology Group, Vall d'Hebron Research Institute, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
Meseguer A; Renal Physiopathology Group, Vall d'Hebron Research Institute, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain. .; Unitat de Bioquímica de Medicina, Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 09; Vol. 13 (1), pp. 19552. Date of Electronic Publication: 2023 Nov 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Renal Cell*/genetics
Kidney Neoplasms*/genetics
Humans ; Phosphorylation ; Serine/genetics ; Serine/metabolism ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
Functional analysis of a putative HER2-associated expressed enhancer, Her2-Enhancer1, in breast cancer cells.
Autorzy:
Rojhannezhad M; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Soltani BM; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Vasei M; Cell-Based Therapies Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Ghorbanmehr N; Biotechnology Department, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.
Mowla SJ; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 09; Vol. 13 (1), pp. 19516. Date of Electronic Publication: 2023 Nov 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Neoplasms*/genetics
Phosphatidylinositol 3-Kinases/metabolism ; Oncogenes ; Phosphorylation ; Blotting, Western
Czasopismo naukowe
Tytuł:
Glucose restriction in Saccharomyces cerevisiae modulates the phosphorylation pattern of the 20S proteasome and increases its activity.
Autorzy:
Bicev RN; Departamento de Bioquímica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
de Souza Degenhardt MF; Departamento de Física Experimental, Instituto de Física, Universidade de São Paulo, São Paulo, SP, Brasil.
de Oliveira CLP; Departamento de Física Experimental, Instituto de Física, Universidade de São Paulo, São Paulo, SP, Brasil.
da Silva ER; Departamento de Biofísica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
Degrouard J; Université Paris-Saclay, CNRS, Laboratoire de Physique des Solides, 91405, Orsay, France.
Tresset G; Université Paris-Saclay, CNRS, Laboratoire de Physique des Solides, 91405, Orsay, France.
Ronsein GE; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brasil.
Demasi M; Laboratório de Bioquímica, Instituto Butantan, São Paulo, SP, Brasil. .
da Cunha FM; Departamento de Bioquímica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 08; Vol. 13 (1), pp. 19383. Date of Electronic Publication: 2023 Nov 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Proteasome Endopeptidase Complex*
Saccharomyces cerevisiae*
Phosphorylation ; Cytoplasm ; Glucose
Czasopismo naukowe
Tytuł:
Primate-specific isoform of Nedd4-1 regulates substrate binding via Ser/Thr phosphorylation and 14-3-3 binding.
Autorzy:
Kefalas G; Cell Biology Program, the Hospital for Sick Children, PGCRL 19-9715, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.; Biochemistry Department, University of Toronto, Toronto, ON, M5G 0A4, Canada.
Rotin D; Cell Biology Program, the Hospital for Sick Children, PGCRL 19-9715, 686 Bay Street, Toronto, ON, M5G 0A4, Canada. .; Biochemistry Department, University of Toronto, Toronto, ON, M5G 0A4, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 20; Vol. 13 (1), pp. 17903. Date of Electronic Publication: 2023 Oct 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
14-3-3 Proteins*/genetics
Alternative Splicing*
Animals ; Humans ; Endosomal Sorting Complexes Required for Transport/genetics ; Nedd4 Ubiquitin Protein Ligases/genetics ; Phosphorylation ; Primates ; Protein Binding ; Protein Isoforms/genetics ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination
Czasopismo naukowe
Tytuł:
PFKM inhibits doxorubicin-induced cardiotoxicity by enhancing oxidative phosphorylation and glycolysis.
Autorzy:
Zhou M; Department of Cardiovascular Surgery, Affiliated 9th People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 201900, China.
Sun X; Department of Cardiovascular Surgery, Affiliated 9th People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 201900, China.
Wang C; Department of Cardiovascular Surgery, Affiliated 9th People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 201900, China.
Wang F; Department of Cardiovascular Surgery, Affiliated 9th People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 201900, China.
Fang C; Department of Cardiovascular Surgery, Affiliated 9th People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 201900, China.
Hu Z; Department of Cardiovascular Surgery, Affiliated 9th People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 201900, China. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jul 08; Vol. 12 (1), pp. 11684. Date of Electronic Publication: 2022 Jul 08.
Typ publikacji:
Journal Article
MeSH Terms:
Cardiotoxicity*/drug therapy
Cardiotoxicity*/genetics
Cardiotoxicity*/prevention & control
Oxidative Phosphorylation*
Animals ; Apoptosis ; Doxorubicin ; Glycolysis ; Humans ; Myocytes, Cardiac/metabolism ; Oxidative Stress ; Phosphofructokinase-1, Muscle Type ; Rats
Czasopismo naukowe
Tytuł:
Fuzzy interactions between the auto-phosphorylated C-terminus and the kinase domain of CK1δ inhibits activation of TAp63α.
Autorzy:
Lambert M; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt/Main, Germany.
Gebel J; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt/Main, Germany.
Trejtnar C; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt/Main, Germany.
Wesch N; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt/Main, Germany.
Bozkurt S; Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt/Main, Germany.
Adrian-Allgood M; Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt/Main, Germany.
Löhr F; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt/Main, Germany.
Münch C; Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt/Main, Germany.; Frankfurt Cancer Institute, Frankfurt/Main, Germany.; Cardio-Pulmonary Institute, Frankfurt/Main, Germany.
Dötsch V; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt/Main, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 30; Vol. 13 (1), pp. 16423. Date of Electronic Publication: 2023 Sep 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Damage*
Apoptosis*
Phosphorylation ; Oocytes/metabolism ; DNA Breaks, Double-Stranded
Czasopismo naukowe
Tytuł:
Remdesivir increases mtDNA copy number causing mild alterations to oxidative phosphorylation.
Autorzy:
DeFoor N; School of Neuroscience, Virginia Tech, Life Science I Room 217, 970 Washington Street SW, Blacksburg, VA, 24061, USA.
Paul S; Graduate Program in Biomedical and Veterinary Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, 24061, USA.
Li S; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, 29425, USA.
Basso EKG; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, 24061, USA.
Stevenson V; Virginia Tech Animal Laboratory Services, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, 24061, USA.
Browning JL; School of Neuroscience, Virginia Tech, Life Science I Room 217, 970 Washington Street SW, Blacksburg, VA, 24061, USA.
Prater AK; School of Neuroscience, Virginia Tech, Life Science I Room 217, 970 Washington Street SW, Blacksburg, VA, 24061, USA.
Brindley S; School of Neuroscience, Virginia Tech, Life Science I Room 217, 970 Washington Street SW, Blacksburg, VA, 24061, USA.
Tao G; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, 29425, USA.
Pickrell AM; School of Neuroscience, Virginia Tech, Life Science I Room 217, 970 Washington Street SW, Blacksburg, VA, 24061, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 15; Vol. 13 (1), pp. 15339. Date of Electronic Publication: 2023 Sep 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
DNA, Mitochondrial*/genetics
COVID-19*
Humans ; Oxidative Phosphorylation ; DNA Copy Number Variations ; Nucleosides ; COVID-19 Drug Treatment ; SARS-CoV-2 ; Mitochondria/genetics
Czasopismo naukowe

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