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Tytuł:
Exploring the role of LIAS-related cuproptosis in systemic lupus erythematosus.
Autorzy:
Li Y; Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.; Xiamen Municipal Clinical Research Center for Immune Diseases, Xiamen, China.; Xiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, China.
Xu B; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Zhang J; Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.; Xiamen Municipal Clinical Research Center for Immune Diseases, Xiamen, China.; Xiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, China.
Liu X; Department of Dermatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Ganesan K; School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.
Shi G; Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.; Xiamen Municipal Clinical Research Center for Immune Diseases, Xiamen, China.; Xiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, China.
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Źródło:
Lupus [Lupus] 2023 Dec; Vol. 32 (14), pp. 1598-1609. Date of Electronic Publication: 2023 Oct 30.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Leukocytes, Mononuclear*
Lupus Erythematosus, Systemic*/genetics
Sulfurtransferases*/genetics
Humans ; Cell Communication ; Copper ; Gene Regulatory Networks ; Phosphorylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Fuzzy interactions between the auto-phosphorylated C-terminus and the kinase domain of CK1δ inhibits activation of TAp63α.
Autorzy:
Lambert M; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt/Main, Germany.
Gebel J; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt/Main, Germany.
Trejtnar C; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt/Main, Germany.
Wesch N; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt/Main, Germany.
Bozkurt S; Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt/Main, Germany.
Adrian-Allgood M; Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt/Main, Germany.
Löhr F; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt/Main, Germany.
Münch C; Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt/Main, Germany.; Frankfurt Cancer Institute, Frankfurt/Main, Germany.; Cardio-Pulmonary Institute, Frankfurt/Main, Germany.
Dötsch V; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt/Main, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 30; Vol. 13 (1), pp. 16423. Date of Electronic Publication: 2023 Sep 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Damage*
Apoptosis*
Phosphorylation ; Oocytes/metabolism ; DNA Breaks, Double-Stranded
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery of Pyrimidine- and Coumarin-Linked Hybrid Molecules as Inducers of JNK Phosphorylation through ROS Generation in Breast Cancer Cells.
Autorzy:
Kim NY; Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Vishwanath D; Laboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India.
Xi Z; Shenzhen Bay Laboratory, Shenzhen 518055, China.
Nagaraja O; Department of Studies in Physics, University of Mysore, Manasagangotri, Mysore 570006, India.
Swamynayaka A; Department of Studies in Physics, University of Mysore, Manasagangotri, Mysore 570006, India.
Kumar Harish K; Department of Studies in Physics, University of Mysore, Manasagangotri, Mysore 570006, India.
Basappa S; Department of Chemistry, BITS-Pilani Hyderabad Campus, Jawahar Nagar, Medchal 500078, India.
Madegowda M; Department of Studies in Physics, University of Mysore, Manasagangotri, Mysore 570006, India.
Pandey V; Tsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Sethi G; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.
Lobie PE; Shenzhen Bay Laboratory, Shenzhen 518055, China.; Tsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Ahn KS; Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Basappa B; Laboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Apr 13; Vol. 28 (8). Date of Electronic Publication: 2023 Apr 13.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Breast Neoplasms*/metabolism
Humans ; Female ; Phosphorylation ; Reactive Oxygen Species/metabolism ; Coumarins/pharmacology ; Pyrimidines ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Redundant roles of extra-cellular signal-regulated kinase (ERK) 1 and 2 in the G1-S transition and etoposide-induced G2/M checkpoint in HCT116 cells.
Autorzy:
Erdenebaatar P; Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Gunarta IK; Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Suzuki R; Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Odongoo R; Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Fujii T; Department of Biochemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Fukunaga R; Department of Biochemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Kanemaki MT; Department of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Mishima, Japan.; Department of Genetics, The Graduate University for Advanced Studies (SOKENDAI), Mishima, Japan.
Yoshioka K; Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
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Źródło:
Drug discoveries & therapeutics [Drug Discov Ther] 2023 Mar 11; Vol. 17 (1), pp. 10-17. Date of Electronic Publication: 2023 Jan 14.
Typ publikacji:
Journal Article
MeSH Terms:
Extracellular Signal-Regulated MAP Kinases*
Apoptosis*
Humans ; Etoposide ; HCT116 Cells ; G2 Phase Cell Cycle Checkpoints ; Cell Line, Tumor ; Phosphorylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Endoplasmic reticulum stress mediates parathyroid hormone-induced apoptosis in vascular smooth muscle cells.
Autorzy:
Duan S; Department of Nephrology, Beijing Friendship Hospital, Faculty of Kidney Diseases, Capital Medical University, Beijing, China.; Department of Nephrology, Chengde Medical University Affiliated Hospital, Chengde, China.
Chen X; Department of Nephrology, Beijing Friendship Hospital, Faculty of Kidney Diseases, Capital Medical University, Beijing, China.
Liu Y; Department of Nephrology, Beijing Friendship Hospital, Faculty of Kidney Diseases, Capital Medical University, Beijing, China.
Guo W; Department of Nephrology, Beijing Friendship Hospital, Faculty of Kidney Diseases, Capital Medical University, Beijing, China.
Liu W; Department of Nephrology, Beijing Friendship Hospital, Faculty of Kidney Diseases, Capital Medical University, Beijing, China.
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Źródło:
Renal failure [Ren Fail] 2022 Dec; Vol. 44 (1), pp. 126-136.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Endoplasmic Reticulum Stress*
Aorta/*metabolism
Myocytes, Smooth Muscle/*metabolism
Parathyroid Hormone/*metabolism
Vascular Calcification/*metabolism
Activating Transcription Factor 4/metabolism ; Anthracenes/pharmacology ; Aorta/pathology ; Cells, Cultured ; Humans ; MAP Kinase Signaling System/drug effects ; Phosphorylation ; RNA, Small Interfering/metabolism ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/pathology ; Vascular Calcification/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ginsenoside Rh2 stimulates the production of mitochondrial reactive oxygen species and induces apoptosis of cervical cancer cells by inhibiting mitochondrial electron transfer chain complex.
Autorzy:
Liu Y; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China.
Yu S; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China.
Xing X; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China.
Qiao J; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China.
Yin Y; GeneScience Pharmaceuticals Co., Ltd., Changchun, Jilin 130012, P.R. China.
Wang J; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China.
Liu M; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China.
Zhang W; Scientific Research Department, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2021 Dec; Vol. 24 (6). Date of Electronic Publication: 2021 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Ginsenosides/*metabolism
Mitochondria/*metabolism
Reactive Oxygen Species/*metabolism
Uterine Cervical Neoplasms/*metabolism
Cell Survival ; Female ; Ginsenosides/chemistry ; Ginsenosides/genetics ; HeLa Cells ; Humans ; Membrane Potential, Mitochondrial ; Mitochondrial Membranes/metabolism ; Molecular Docking Simulation ; Oxidative Phosphorylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The interplay between SUMOylation and phosphorylation of PKCδ facilitates oxidative stress-induced apoptosis.
Autorzy:
Gao S; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, China.
Zhao X; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, China.
Hou L; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, China.
Ma R; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, China.
Zhou J; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, China.
Zhu MX; Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, TX, USA.
Pan SJ; Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China.
Li Y; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, China.
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Źródło:
The FEBS journal [FEBS J] 2021 Nov; Vol. 288 (22), pp. 6447-6464. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*/drug effects
Protein Kinase C-delta/*metabolism
Animals ; CHO Cells ; Cricetulus ; Hydrogen Peroxide/pharmacology ; Mice ; Mice, Inbred C57BL ; Oxidative Stress/drug effects ; Phosphorylation ; Sumoylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Endoplasmic Reticulum Stress Contributed to Dipyridamole-Induced Impaired Autophagic Flux and Glioma Apoptosis.
Autorzy:
Chang CY; Department of Surgery, Feng Yuan Hospital, Taichung 420, Taiwan.; Department of Veterinary Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Wu CC; Department of Anesthesiology, Taichung Veterans General Hospital, Taichung 407, Taiwan.; Department of Financial Engineering, Providence University, Taichung 433, Taiwan.; Department of Data Science and Big Data Analytics, Providence University, Taichung 433, Taiwan.
Wang JD; Children's Medical Center, Taichung Veterans General Hospital, Taichung 407, Taiwan.; Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung 407, Taiwan.
Liao SL; Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan.
Chen WY; Department of Veterinary Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Kuan YH; Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
Wang WY; Department of Nursing, Hung Kuang University, Taichung 433, Taiwan.
Chen CJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan.; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 06; Vol. 23 (2). Date of Electronic Publication: 2022 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Autophagy*
Endoplasmic Reticulum Stress*
Dipyridamole/*pharmacology
Glioblastoma/*drug therapy
Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Glioblastoma/physiopathology ; Humans ; Phosphodiesterase Inhibitors/pharmacology ; Phosphorylation ; Protein Processing, Post-Translational ; Proto-Oncogene Proteins c-bcl-2/genetics ; YAP-Signaling Proteins/genetics ; YAP-Signaling Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload.
Autorzy:
Shao D; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, 185 S Orange Ave, MSB G609, Newark, NJ, 07103, USA.
Zhai P; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, 185 S Orange Ave, MSB G609, Newark, NJ, 07103, USA.
Hu C; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, 185 S Orange Ave, MSB G609, Newark, NJ, 07103, USA.
Mukai R; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, 185 S Orange Ave, MSB G609, Newark, NJ, 07103, USA.
Sciarretta S; Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.; IRCCS Neuromed, Pozzilli, IS, Italy.
Del Re D; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, 185 S Orange Ave, MSB G609, Newark, NJ, 07103, USA.
Sadoshima J; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, 185 S Orange Ave, MSB G609, Newark, NJ, 07103, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Dec 06; Vol. 11 (1), pp. 23469. Date of Electronic Publication: 2021 Dec 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*physiology
Heart Failure/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Tumor Suppressor Protein p53/*metabolism
Tumor Suppressor Proteins/*metabolism
Animals ; Cardiomegaly/metabolism ; Cardiomegaly/pathology ; Female ; Heart Failure/pathology ; Hippo Signaling Pathway/physiology ; Male ; Mice ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Phosphorylation/physiology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Rats, Wistar ; Up-Regulation/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The PirB toxin protein from Vibrio parahaemolyticus induces apoptosis in hemocytes of Penaeus vannamei .
Autorzy:
Zheng Z; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University , Shantou, China.; STU-UMT Joint Shellfish Research Laboratory, Shantou University , Shantou, China.
Li R; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University , Shantou, China.; STU-UMT Joint Shellfish Research Laboratory, Shantou University , Shantou, China.
Aweya JJ; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University , Shantou, China.; STU-UMT Joint Shellfish Research Laboratory, Shantou University , Shantou, China.
Yao D; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University , Shantou, China.; STU-UMT Joint Shellfish Research Laboratory, Shantou University , Shantou, China.
Wang F; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University , Shantou, China.; STU-UMT Joint Shellfish Research Laboratory, Shantou University , Shantou, China.
Li S; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University , Shantou, China.; STU-UMT Joint Shellfish Research Laboratory, Shantou University , Shantou, China.
Tuan TN; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University , Shantou, China.; STU-UMT Joint Shellfish Research Laboratory, Shantou University , Shantou, China.
Zhang Y; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University , Shantou, China.; STU-UMT Joint Shellfish Research Laboratory, Shantou University , Shantou, China.; Southern Marine Science and Engineering Guangdong Laboratory , Guangzhou, China.
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Źródło:
Virulence [Virulence] 2021 Dec; Vol. 12 (1), pp. 481-492.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*genetics
Bacterial Toxins/*genetics
Bacterial Toxins/*metabolism
Hemocytes/*pathology
Histones/*metabolism
Vibrio parahaemolyticus/*chemistry
Animals ; Aquaculture ; Drosophila/cytology ; Hepatopancreas/pathology ; Penaeidae/cytology ; Penaeidae/microbiology ; Phosphorylation ; Recombinant Proteins/genetics ; Vibrio parahaemolyticus/pathogenicity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Phosphocatalytic Kinome Activity Profiling of Apoptotic and Ferroptotic Agents in Multiple Myeloma Cells.
Autorzy:
Logie E; Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES) and Integrated Personalized and Precision Oncology Network (IPPON), Department of Biomedical Sciences, Campus Drie Eiken, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium.
Novo CP; Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES) and Integrated Personalized and Precision Oncology Network (IPPON), Department of Biomedical Sciences, Campus Drie Eiken, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium.
Driesen A; Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES) and Integrated Personalized and Precision Oncology Network (IPPON), Department of Biomedical Sciences, Campus Drie Eiken, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium.
Van Vlierberghe P; Department of Biomolecular Medicine, Ghent University, B-9000 Ghent, Belgium.
Vanden Berghe W; Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES) and Integrated Personalized and Precision Oncology Network (IPPON), Department of Biomedical Sciences, Campus Drie Eiken, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 25; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 25.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Ferroptosis*
Carbolines/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Multiple Myeloma/*pathology
Phosphoproteins/*metabolism
Protein Kinases/*metabolism
Staurosporine/*pharmacology
Antineoplastic Agents/pharmacology ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Enzyme Inhibitors/pharmacology ; Humans ; Multiple Myeloma/drug therapy ; Multiple Myeloma/genetics ; Multiple Myeloma/metabolism ; Phosphoproteins/genetics ; Phosphorylation ; Prognosis ; Protein Kinases/genetics ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Acetylenic Synthetic Betulin Derivatives Inhibit Akt and Erk Kinases Activity, Trigger Apoptosis and Suppress Proliferation of Neuroblastoma and Rhabdomyosarcoma Cell Lines.
Autorzy:
Król SK; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland.
Bębenek E; Department of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Dmoszyńska-Graniczka M; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland.
Sławińska-Brych A; Department of Cell Biology, Faculty of Biology and Biotechnology, Institute of Biological Sciences, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.
Boryczka S; Department of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Stepulak A; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 14; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 14.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Extracellular Signal-Regulated MAP Kinases/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-akt/*antagonists & inhibitors
Triterpenes/*pharmacology
Acetylene/chemistry ; Antineoplastic Agents/pharmacology ; Betula/chemistry ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Cisplatin/pharmacology ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Molecular Structure ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Proto-Oncogene Proteins c-akt/metabolism ; Rhabdomyosarcoma/metabolism ; Rhabdomyosarcoma/pathology ; Temozolomide/pharmacology ; Triterpenes/chemical synthesis ; Triterpenes/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cellular Protein Phosphatase 2A Regulates Cell Survival Mechanisms in Influenza A Virus Infection.
Autorzy:
Gerlt V; Institute of Virology Muenster, University of Muenster, 48149 Muenster, Germany.
Mayr J; Institute of Virology Muenster, University of Muenster, 48149 Muenster, Germany.
Del Sarto J; Institute of Virology Muenster, University of Muenster, 48149 Muenster, Germany.; Department of Neurology, Institute of Translational Neurology, Medical Faculty, University Hospital Muenster, 48149 Muenster, Germany.
Ludwig S; Institute of Virology Muenster, University of Muenster, 48149 Muenster, Germany.
Boergeling Y; Institute of Virology Muenster, University of Muenster, 48149 Muenster, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 16; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 16.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Cell Survival*
Influenza A virus/*physiology
Influenza, Human/*immunology
Influenza, Human/*virology
Orthomyxoviridae Infections/*virology
Protein Phosphatase 2/*physiology
A549 Cells ; Animals ; Cell Line ; Dogs ; Gene Knockdown Techniques ; Host Microbial Interactions ; Humans ; Madin Darby Canine Kidney Cells ; Phosphorylation ; Signal Transduction ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
N -Acetylcysteine Inhibits Patulin-Induced Apoptosis by Affecting ROS-Mediated Oxidative Damage Pathway.
Autorzy:
Liu J; College of Food Science and Engineering, Northwest A & F University, Yangling 712100, China.
Liu Q; College of Food Science and Engineering, Northwest A & F University, Yangling 712100, China.
Han J; College of Food Science and Engineering, Northwest A & F University, Yangling 712100, China.
Feng J; College of Food Science and Engineering, Northwest A & F University, Yangling 712100, China.
Guo T; College of Food Science and Engineering, Northwest A & F University, Yangling 712100, China.
Li Z; College of Food Science and Engineering, Northwest A & F University, Yangling 712100, China.
Min F; College of Food Science and Engineering, Northwest A & F University, Yangling 712100, China.
Jin R; College of Food Science and Engineering, Northwest A & F University, Yangling 712100, China.
Peng X; College of Food Science and Engineering, Northwest A & F University, Yangling 712100, China.
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Źródło:
Toxins [Toxins (Basel)] 2021 Aug 26; Vol. 13 (9). Date of Electronic Publication: 2021 Aug 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetylcysteine/*metabolism
Acetylcysteine/*pharmacology
Apoptosis/*drug effects
Oxidative Phosphorylation/*drug effects
Oxidative Stress/*drug effects
Patulin/*toxicity
Reactive Oxygen Species/*metabolism
Cells, Cultured/drug effects ; HEK293 Cells/drug effects ; Humans ; Metabolic Networks and Pathways ; Mitochondria/metabolism ; Mycotoxins/toxicity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Sulforaphane Causes Cell Cycle Arrest and Apoptosis in Human Glioblastoma U87MG and U373MG Cell Lines under Hypoxic Conditions.
Autorzy:
Sita G; Department of Pharmacy and BioTechnology-FaBiT, University of Bologna-Alma Mater Studiorum, Via Irnerio 48, 40126 Bologna, Italy.
Graziosi A; Department of Pharmacy and BioTechnology-FaBiT, University of Bologna-Alma Mater Studiorum, Via Irnerio 48, 40126 Bologna, Italy.
Hrelia P; Department of Pharmacy and BioTechnology-FaBiT, University of Bologna-Alma Mater Studiorum, Via Irnerio 48, 40126 Bologna, Italy.
Morroni F; Department of Pharmacy and BioTechnology-FaBiT, University of Bologna-Alma Mater Studiorum, Via Irnerio 48, 40126 Bologna, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 18; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 18.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Brain Neoplasms/*drug therapy
Glioblastoma/*drug therapy
Isothiocyanates/*pharmacology
Sulfoxides/*pharmacology
Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/pharmacology ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Glutathione/metabolism ; Humans ; Isothiocyanates/administration & dosage ; MAP Kinase Signaling System/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Phosphorylation/drug effects ; Sulfoxides/administration & dosage ; Tumor Hypoxia/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cycloastragenol, a Triterpenoid Saponin, Regulates Oxidative Stress, Neurotrophic Dysfunctions, Neuroinflammation and Apoptotic Cell Death in Neurodegenerative Conditions.
Autorzy:
Ikram M; Division of Life Science and Applied Life Science (BK21 Four), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Korea.
Jo MH; Division of Life Science and Applied Life Science (BK21 Four), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Korea.
Choe K; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, 6211 LK Maastricht, The Netherlands.
Khan A; Division of Life Science and Applied Life Science (BK21 Four), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Korea.
Ahmad S; Division of Life Science and Applied Life Science (BK21 Four), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Korea.
Saeed K; Division of Life Science and Applied Life Science (BK21 Four), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Korea.
Kim MW; Division of Life Science and Applied Life Science (BK21 Four), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Korea.
Kim MO; Division of Life Science and Applied Life Science (BK21 Four), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Korea.; Alz-Dementia Korea Co., Jinju 52828, Korea.
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Źródło:
Cells [Cells] 2021 Oct 11; Vol. 10 (10). Date of Electronic Publication: 2021 Oct 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*/drug effects
Oxidative Stress*/drug effects
Brain/*pathology
Inflammation/*drug therapy
Nerve Growth Factors/*metabolism
Neurodegenerative Diseases/*drug therapy
Sapogenins/*therapeutic use
Saponins/*therapeutic use
Alzheimer Disease/complications ; Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/administration & dosage ; Amyloid beta-Peptides/metabolism ; Animals ; Astrocytes/drug effects ; Astrocytes/metabolism ; Cyclic AMP Response Element-Binding Protein/metabolism ; Cytokines/metabolism ; DNA-Binding Proteins/metabolism ; Disease Models, Animal ; Inflammation/complications ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Memory Disorders/complications ; Memory Disorders/drug therapy ; Mice, Inbred C57BL ; Microglia/drug effects ; Microglia/metabolism ; Nerve Tissue Proteins/metabolism ; Neurodegenerative Diseases/complications ; Phosphorylation/drug effects ; Sapogenins/pharmacology ; Saponins/pharmacology ; Triterpenes/pharmacology ; Triterpenes/therapeutic use ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Stress Relief Techniques: p38 MAPK Determines the Balance of Cell Cycle and Apoptosis Pathways.
Autorzy:
Whitaker RH; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Cook JG; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
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Źródło:
Biomolecules [Biomolecules] 2021 Oct 02; Vol. 11 (10). Date of Electronic Publication: 2021 Oct 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:
Apoptosis/*genetics
Cell Cycle/*genetics
p38 Mitogen-Activated Protein Kinases/*genetics
Cell Cycle Checkpoints/genetics ; DNA Repair/genetics ; Humans ; Phosphorylation/genetics ; Protein Interaction Maps/genetics ; Protein Processing, Post-Translational/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway.
Autorzy:
Seo HY; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
Lee SH; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
Lee JH; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
Lee JH; Department of Anatomy, Keimyung University School of Medicine, Dageu 42601, Korea.
Jang BK; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
Kim MK; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 29; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 29.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*metabolism
Diterpenes/*pharmacology
Liver Neoplasms/*metabolism
STAT3 Transcription Factor/*metabolism
Signal Transduction/*drug effects
TOR Serine-Threonine Kinases/*metabolism
src-Family Kinases/*metabolism
Animals ; Apoptosis/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Phosphorylation/drug effects ; RNA-Seq/methods ; STAT3 Transcription Factor/genetics ; Signal Transduction/genetics ; Survival Analysis ; TOR Serine-Threonine Kinases/genetics ; src-Family Kinases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer.
Autorzy:
Hwang WY; Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 13620, Korea.; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, Korea.
Park WH; Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 13620, Korea.
Suh DH; Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 13620, Korea.; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, Korea.
Kim K; Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 13620, Korea.; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, Korea.
Kim YB; Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 13620, Korea.; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, Korea.
No JH; Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 13620, Korea.; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 23; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 23.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Carcinoma, Ovarian Epithelial/*drug therapy
Eflornithine/*pharmacology
MAP Kinase Signaling System/*drug effects
Ovarian Neoplasms/*drug therapy
Phosphorylation/*drug effects
Transcription Factor AP-1/*metabolism
Carcinoma, Ovarian Epithelial/metabolism ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Down-Regulation/drug effects ; Female ; Humans ; Ornithine Decarboxylase/metabolism ; Ovarian Neoplasms/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction/drug effects ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Atypical Cyclin-Dependent Kinase 5 (Cdk5) Guards Podocytes from Apoptosis in Glomerular Disease While Being Dispensable for Podocyte Development.
Autorzy:
Mangold N; Center for Molecular Medicine Cologne, Department II of Internal Medicine, Faculty of Medicine-University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Pippin J; Division of Nephrology, University of Washington, Seattle, WA 98195, USA.
Unnersjoe-Jess D; Center for Molecular Medicine Cologne, Department II of Internal Medicine, Faculty of Medicine-University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Koehler S; Center for Molecular Medicine Cologne, Department II of Internal Medicine, Faculty of Medicine-University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Shankland S; Division of Nephrology, University of Washington, Seattle, WA 98195, USA.
Brähler S; Center for Molecular Medicine Cologne, Department II of Internal Medicine, Faculty of Medicine-University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Schermer B; Center for Molecular Medicine Cologne, Department II of Internal Medicine, Faculty of Medicine-University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.; Cologne Cluster of Excellence on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Systems Biology of Ageing Cologne (Sybacol), University of Cologne, 50935 Cologne, Germany.
Benzing T; Center for Molecular Medicine Cologne, Department II of Internal Medicine, Faculty of Medicine-University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.; Cologne Cluster of Excellence on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Systems Biology of Ageing Cologne (Sybacol), University of Cologne, 50935 Cologne, Germany.
Brinkkoetter PT; Center for Molecular Medicine Cologne, Department II of Internal Medicine, Faculty of Medicine-University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Hagmann H; Center for Molecular Medicine Cologne, Department II of Internal Medicine, Faculty of Medicine-University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
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Źródło:
Cells [Cells] 2021 Sep 18; Vol. 10 (9). Date of Electronic Publication: 2021 Sep 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Cell Differentiation*
Cyclin-Dependent Kinase 5/*physiology
Glomerulosclerosis, Focal Segmental/*pathology
Podocytes/*cytology
Animals ; Cells, Cultured ; Glomerulosclerosis, Focal Segmental/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphorylation ; Podocytes/metabolism ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 15942

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