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Tytuł:
Chromium Picolinate Regulates Bone Metabolism and Prevents Bone Loss in Diabetic Rats.
Autorzy:
Zheng H; School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China.; State Key Laboratory of Qinba Biological Resources and Ecological Environment, Hanzhong 723000, China.; Shaanxi Black Organic Food Engineering Technology Research Center, Hanzhong 723000, China.
Yan W; School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China.; Qinba Mountain Area Collaborative Innovation Center of Bioresources Comprehensive Development, Hanzhong 723000, China.
Shao M; School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China.; Shaanxi Provincial Key Laboratory of Resource Biology, Hanzhong 723001, China.
Qi S; School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China.; Shaanxi Migukang Biotechnology Company, Xi'an 710018, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 20; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Experimental*/metabolism
Bone Diseases, Metabolic*
Osteoporosis*/metabolism
Picolinic Acids*
Rats ; Animals ; Blood Glucose/metabolism ; Bone Density ; RANK Ligand
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, Synthesis and Gene Modulation Insights into Pigments Derived from Tryptophan-Betaxanthin, Which Act against Tumor Development in Caenorhabditis elegans .
Autorzy:
Henarejos-Escudero P; Department of Biochemistry and Molecular Biology A, Faculty of Biology, Regional Campus of International Excellence, Campus Mare Nostrum, University of Murcia, 30100 Murcia, Spain.
Méndez-García FF; Department of Biochemistry and Molecular Biology A, Faculty of Biology, Regional Campus of International Excellence, Campus Mare Nostrum, University of Murcia, 30100 Murcia, Spain.
Hernández-García S; Department of Biochemistry and Molecular Biology A, Faculty of Biology, Regional Campus of International Excellence, Campus Mare Nostrum, University of Murcia, 30100 Murcia, Spain.
Martínez-Rodríguez P; Department of Biochemistry and Molecular Biology A, Faculty of Biology, Regional Campus of International Excellence, Campus Mare Nostrum, University of Murcia, 30100 Murcia, Spain.
Gandía-Herrero F; Department of Biochemistry and Molecular Biology A, Faculty of Biology, Regional Campus of International Excellence, Campus Mare Nostrum, University of Murcia, 30100 Murcia, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 20; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 20.
Typ publikacji:
Journal Article
MeSH Terms:
Caenorhabditis elegans*/genetics
Neoplasms*/drug therapy
Neoplasms*/genetics
Picolinic Acids*
Animals ; Betaxanthins ; Tryptophan/pharmacology ; Betalains ; Esters
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Study on Design, Synthesis and Herbicidal Activity of Novel 6-Indazolyl-2-picolinic Acids.
Autorzy:
Liu Q; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.; Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University, Beijing 100193, China.
Shi RC; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.; Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University, Beijing 100193, China.
Li HT; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Wei W; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Yuan X; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Liu SZ; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.; Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University, Beijing 100193, China.
Cao YM; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.; Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University, Beijing 100193, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Jan 09; Vol. 29 (2). Date of Electronic Publication: 2024 Jan 09.
Typ publikacji:
Journal Article
MeSH Terms:
Herbicides*/pharmacology
Arabidopsis*
Picolinic Acids/pharmacology ; Picloram ; Biological Transport ; Indoleacetic Acids/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rapid detection and quantitation of dipicolinic acid from Clostridium botulinum spores using mixed-mode liquid chromatography-tandem mass spectrometry.
Autorzy:
Redan BW; Division of Food Processing Science and Technology, Office of Food Safety, U.S. Food and Drug Administration, 6502 South Archer Road, Bedford Park, IL, USA. .
Morrissey TR; Division of Food Processing Science and Technology, Office of Food Safety, U.S. Food and Drug Administration, 6502 South Archer Road, Bedford Park, IL, USA.
Rolfe CA; Division of Food Processing Science and Technology, Office of Food Safety, U.S. Food and Drug Administration, 6502 South Archer Road, Bedford Park, IL, USA.
Aguilar VL; Institute for Food Safety and Health, Illinois Institute of Technology, 6502 South Archer Road, Bedford Park, IL, USA.
Skinner GE; Multi-Component Foods, Food Process Evaluation Team, Office of Food Safety, U.S. Food and Drug Administration, 5001 Campus Drive, College Park, MD, USA.
Reddy NR; Division of Food Processing Science and Technology, Office of Food Safety, U.S. Food and Drug Administration, 6502 South Archer Road, Bedford Park, IL, USA.
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2022 Mar; Vol. 414 (8), pp. 2767-2774. Date of Electronic Publication: 2022 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
Clostridium botulinum*/chemistry
Picolinic Acids*/analysis
Chromatography, Liquid ; Hot Temperature ; Spores, Bacterial/chemistry ; Tandem Mass Spectrometry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effect of Moderate Hepatic Impairment on the Pharmacokinetics of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor.
Autorzy:
Chavan A; Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.
Burke L; Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.
Sawant R; Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.
Navarro-Gonzales P; Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.
Vargo D; Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.
Paulson SK; Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2021 Aug; Vol. 10 (8), pp. 950-958. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji:
Clinical Trial, Phase I; Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Fasting/*blood
Glycine/*analogs & derivatives
Liver Diseases/*physiopathology
Picolinic Acids/*administration & dosage
Prolyl-Hydroxylase Inhibitors/*administration & dosage
Administration, Oral ; Aged ; Area Under Curve ; Female ; Glycine/administration & dosage ; Glycine/adverse effects ; Glycine/pharmacokinetics ; Humans ; Male ; Middle Aged ; Picolinic Acids/adverse effects ; Picolinic Acids/pharmacokinetics ; Prolyl-Hydroxylase Inhibitors/adverse effects ; Prolyl-Hydroxylase Inhibitors/pharmacokinetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and Biological Evaluation of Novel 4-(4-Formamidophenylamino)- N -methylpicolinamide Derivatives as Potential Antitumor Agents.
Autorzy:
Meng N; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.; Hairong Research Institute, Sichuan Hairong Pharmaceutical Co., Ltd., Yangtze River Pharmaceutical Group, Chengdu 611830, China.
Zhou S; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.
Hu M; Open Laboratory, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Xu Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.
Xia Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.
Zeng X; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.
Yu L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 21; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Picolinic Acids/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology ; Picolinic Acids/chemical synthesis ; Picolinic Acids/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Development of Radiofluorinated Nicotinamide/Picolinamide Derivatives as Diagnostic Probes for the Detection of Melanoma.
Autorzy:
Lo YH; Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan.
Chang TY; Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan.
Chen CL; Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan.
Lin MH; Department of Nuclear Medicine, Taipei City Hospital Zhongxiao Branch, Taipei 115, Taiwan.; Department of Nuclear Medicine, Cheng Hsin General Hospital, Taipei 112, Taiwan.
Wang HE; Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan.
Chang CW; Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Liu RS; Department of Nuclear Medicine, Cheng Hsin General Hospital, Taipei 112, Taiwan.
Wu CY; Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 16; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 16.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorine Radioisotopes*/chemistry
Niacinamide*/chemistry
Picolinic Acids*/chemistry
Radiopharmaceuticals*/chemistry
Melanoma, Experimental/*diagnostic imaging
Animals ; Cell Line, Tumor ; Melanins/metabolism ; Melanoma, Experimental/metabolism ; Melanoma, Experimental/pathology ; Mice ; Positron-Emission Tomography ; Protein Binding ; Tissue Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Wide-Antimicrobial Spectrum of Picolinium Salts.
Autorzy:
Salajkova S; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic.
Benkova M; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.; Department of Epidemiology, University of Defence in Brno, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic.
Marek J; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.; Department of Epidemiology, University of Defence in Brno, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic.
Sleha R; Department of Epidemiology, University of Defence in Brno, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic.
Prchal L; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
Malinak D; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
Dolezal R; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
Sepčić K; Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia.
Gunde-Cimerman N; Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia.
Kuca K; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
Soukup O; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 May 11; Vol. 25 (9). Date of Electronic Publication: 2020 May 11.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Bacterial Agents/*pharmacology
Anti-Infective Agents/*pharmacology
Antiviral Agents/*pharmacology
Picolinic Acids/*chemistry
Picolinic Acids/*pharmacology
Quaternary Ammonium Compounds/*chemistry
Animals ; CHO Cells ; Candida/drug effects ; Cell Survival/drug effects ; Cricetulus ; Fungi/drug effects ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Herpesvirus 3, Human/drug effects ; Microbial Sensitivity Tests ; Picolinic Acids/chemical synthesis ; Quaternary Ammonium Compounds/pharmacology ; Structure-Activity Relationship ; Surface-Active Agents/chemistry ; Surface-Active Agents/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Simultaneous quantification of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate, pipecolic acid and alpha-aminoadipic acid in pyridoxine-dependent epilepsy.
Autorzy:
Xue J; Department of Pediatrics, Peking University First Hospital, Beijing, China.
Wang J; Zhejiang Biosan Biochemical Technologies Co., Ltd, Zhejiang, China.
Gong P; Department of Pediatrics, Peking University First Hospital, Beijing, China.
Wu M; Zhejiang Biosan Biochemical Technologies Co., Ltd, Zhejiang, China.
Yang W; Department of Clinical Laboratory, Peking University First Hospital, Beijing, China.
Jiang S; Department of Clinical Laboratory, Peking University First Hospital, Beijing, China.
Wu Y; Department of Pediatrics, Peking University First Hospital, Beijing, China.
Jiang Y; Department of Pediatrics, Peking University First Hospital, Beijing, China.
Zhang Y; Department of Pediatrics, Peking University First Hospital, Beijing, China.
Yuzyuk T; Department of Pathology, University of Utah, Salt Lake City, UT, USA.; ARUP Laboratories, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA.
Li H; Department of Human Genetics, Emory University, School of Medicine, America, Atlanta, USA.
Yang Z; Department of Pediatrics, Peking University First Hospital, Beijing, China. .
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Źródło:
Scientific reports [Sci Rep] 2019 Aug 06; Vol. 9 (1), pp. 11371. Date of Electronic Publication: 2019 Aug 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
2-Aminoadipic Acid/*analogs & derivatives
2-Aminoadipic Acid/*blood
Epilepsy/*blood
Picolinic Acids/*blood
Pipecolic Acids/*blood
Tandem Mass Spectrometry/*methods
2-Aminoadipic Acid/metabolism ; 2-Aminoadipic Acid/urine ; Biomarkers/blood ; Biomarkers/urine ; Child ; Child, Preschool ; Chromatography, Liquid/methods ; Epilepsy/diagnosis ; Epilepsy/urine ; Female ; Humans ; Infant ; Lysine/metabolism ; Male ; Mass Screening ; Picolinic Acids/metabolism ; Picolinic Acids/urine ; Pipecolic Acids/metabolism ; Pipecolic Acids/urine
SCR Disease Name:
Pyridoxine-dependent epilepsy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Catalytic activity and mechanistic investigation of 1D 2-Picolinic acid based Cu(II) coordination polymer in the selective construction of 1,4-disubstituted triazoles.
Autorzy:
Aier M; Department of Chemistry, National Institute of Technology Nagaland, Chumoukedima, Dimapur, Nagaland, 797103, India.
Gayen FR; Advanced Materials Group, Materials Sciences and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam, 785006, India.
Puzari A; Department of Chemistry, National Institute of Technology Nagaland, Chumoukedima, Dimapur, Nagaland, 797103, India. .
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Źródło:
Scientific reports [Sci Rep] 2022 Aug 26; Vol. 12 (1), pp. 14613. Date of Electronic Publication: 2022 Aug 26.
Typ publikacji:
Journal Article
MeSH Terms:
Polymers*
Triazoles*
Alkynes ; Azides ; Catalysis ; Picolinic Acids
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Detecting Zn(II) Ions in Live Cells with Near-Infrared Fluorescent Probes.
Autorzy:
Fang M; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA. .
Xia S; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA. .
Bi J; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA. .
Wigstrom TP; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA. .
Valenzano L; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA. .
Wang J; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA. .; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. .
Tanasova M; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA. .
Luck RL; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA. .
Liu H; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 Apr 22; Vol. 24 (8). Date of Electronic Publication: 2019 Apr 22.
Typ publikacji:
Journal Article
MeSH Terms:
Amines*/chemistry
Amines*/pharmacology
Carbocyanines*/chemistry
Carbocyanines*/pharmacology
Fluorescent Dyes*/chemistry
Fluorescent Dyes*/pharmacology
Picolinic Acids*/chemistry
Picolinic Acids*/pharmacology
Zinc/*metabolism
HeLa Cells ; Humans ; Microscopy, Fluorescence
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure-activity relationship investigation of benzamide and picolinamide derivatives containing dimethylamine side chain as acetylcholinesterase inhibitors.
Autorzy:
Gao XH; a Key Laboratory Breeding Base of Hu'nan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, College of Pharmacy , Changsha Medical University , Changsha , China.
Liu LB; b College of Chemistry and Chemical Engineering , Hu'nan University , Changsha , China.
Liu HR; b College of Chemistry and Chemical Engineering , Hu'nan University , Changsha , China.
Tang JJ; b College of Chemistry and Chemical Engineering , Hu'nan University , Changsha , China.
Kang L; b College of Chemistry and Chemical Engineering , Hu'nan University , Changsha , China.
Wu H; c College of Pharmacy , Hu'nan University of Chinese Medicine , Changsha , China.
Cui P; c College of Pharmacy , Hu'nan University of Chinese Medicine , Changsha , China.
Yan J; c College of Pharmacy , Hu'nan University of Chinese Medicine , Changsha , China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2018 Dec; Vol. 33 (1), pp. 110-114.
Typ publikacji:
Journal Article
MeSH Terms:
Benzamides/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Dimethylamines/*pharmacology
Picolinic Acids/*pharmacology
Acetylcholinesterase/metabolism ; Amides/chemical synthesis ; Amides/chemistry ; Amides/pharmacology ; Animals ; Benzamides/chemical synthesis ; Benzamides/chemistry ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dimethylamines/chemistry ; Dose-Response Relationship, Drug ; Eels ; Humans ; Models, Molecular ; Molecular Structure ; Picolinic Acids/chemical synthesis ; Picolinic Acids/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeted radiotherapy of pigmented melanoma with I-5-IPN.
Autorzy:
Xu X; Department of Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.; Hubei Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
Yuan L; Department of Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.; Hubei Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
Gai Y; Department of Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.; Hubei Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
Liu Q; Department of Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.; Hubei Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
Yin L; Department of Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.; Hubei Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
Jiang Y; Department of Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.; Hubei Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
Wang Y; Department of Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.; Hubei Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
Zhang Y; Department of Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.; Hubei Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
Lan X; Department of Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China. .; Hubei Key Laboratory of Molecular Imaging, Wuhan, 430022, China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2018 Dec 11; Vol. 37 (1), pp. 306. Date of Electronic Publication: 2018 Dec 11.
Typ publikacji:
Journal Article
MeSH Terms:
Iodine Radioisotopes/*administration & dosage
Melanoma/*radiotherapy
Picolinic Acids/*administration & dosage
Radiopharmaceuticals/*administration & dosage
Amides/administration & dosage ; Amides/chemistry ; Animals ; Humans ; Male ; Melanoma/pathology ; Melanoma, Amelanotic/radiotherapy ; Melanoma, Experimental/pathology ; Melanoma, Experimental/radiotherapy ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Nude ; Picolinic Acids/chemistry ; Radiation Dosage ; Random Allocation ; Skin Neoplasms/radiotherapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Production and characterization of a broad-spectrum antimicrobial 5-butyl-2-pyridine carboxylic acid from Aspergillus fumigatus nHF-01.
Autorzy:
Mandal V; Plant and Microbial Physiology and Biochemistry Laboratory, Department of Botany, University of Gour Banga, Malda, West Bengal, India.
Ghosh NN; Department of Chemistry, University of Gour Banga, Malda, West Bengal, India.
Mitra PK; Department of Botany, Kalyani University, Nadia, West Bengal, India.
Mandal S; Department of Microbiology, University of Calcutta, Kolkata, WB, 700 019, India.
Mandal V; Plant and Microbial Physiology and Biochemistry Laboratory, Department of Botany, University of Gour Banga, Malda, West Bengal, India. .
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Źródło:
Scientific reports [Sci Rep] 2022 Apr 09; Vol. 12 (1), pp. 6006. Date of Electronic Publication: 2022 Apr 09.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Infective Agents*/pharmacology
Aspergillus fumigatus*
Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Carboxylic Acids/pharmacology ; Gram-Negative Bacteria ; Humans ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Picolinic Acids ; Spectroscopy, Fourier Transform Infrared
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of Phosphate Binders and a Dietary Iron Supplement on the Pharmacokinetics of a Single Dose of Vadadustat in Healthy Adults.
Autorzy:
Paulson SK; Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.
Martinez J; Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.
Sawant R; Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.
Burke SK; Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.
Chavan A; Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2022 Apr; Vol. 11 (4), pp. 475-485. Date of Electronic Publication: 2022 Feb 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Iron*
Iron, Dietary*
Adult ; Female ; Glycine/analogs & derivatives ; Humans ; Male ; Phosphates ; Picolinic Acids
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Organization and dynamics of the SpoVAEa protein and its surrounding inner membrane lipids, upon germination of Bacillus subtilis spores.
Autorzy:
Wen J; Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
Vischer NOE; Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
de Vos AL; Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
Manders EMM; Confocal.Nl B.V., Science Park 106, 1098 XG, Amsterdam, The Netherlands.
Setlow P; Department of Molecular Biology and Biophysics, UConn Health, 263 Farmington Avenue, Farmington, CT, 06030-3305, USA.
Brul S; Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands. .
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Źródło:
Scientific reports [Sci Rep] 2022 Mar 23; Vol. 12 (1), pp. 4944. Date of Electronic Publication: 2022 Mar 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bacillus subtilis*/metabolism
Spores, Bacterial*/metabolism
Bacterial Proteins/metabolism ; Fluorescent Dyes/metabolism ; Membrane Lipids/metabolism ; Picolinic Acids/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
M 1 muscarinic receptor activation decreases alcohol consumption via a reduction in consummatory behavior.
Autorzy:
Walker LC; Florey Institute of Neuroscience and Mental Health, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
Campbell EJ; Florey Institute of Neuroscience and Mental Health, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
Huckstep KL; Florey Institute of Neuroscience and Mental Health, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
Chen NA; Florey Institute of Neuroscience and Mental Health, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
Langmead CJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Lawrence AJ; Florey Institute of Neuroscience and Mental Health, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2022 Feb; Vol. 10 (1), pp. e00907.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alcohol Drinking/*metabolism
Consummatory Behavior/*drug effects
Picolinic Acids/*pharmacology
Receptor, Muscarinic M1/*metabolism
Thiazoles/*pharmacology
Alcoholism/physiopathology ; Alcoholism/therapy ; Animals ; Male ; Rats ; Receptor, Muscarinic M1/agonists ; Reward ; Self Administration ; Sucrose/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Design and Evaluation of an l-Dopa-Lazabemide Prodrug for the Treatment of Parkinson's Disease.
Autorzy:
Hoon M; Pharmaceutical Chemistry, School of Pharmacy and Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. .
Petzer JP; Pharmaceutical Chemistry, School of Pharmacy and Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. .
Viljoen F; Pharmacology, School of Pharmacy and Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. .
Petzer A; Pharmaceutical Chemistry, School of Pharmacy and Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2017 Nov 27; Vol. 22 (12). Date of Electronic Publication: 2017 Nov 27.
Typ publikacji:
Journal Article
MeSH Terms:
Levodopa/*chemistry
Monoamine Oxidase Inhibitors/*chemistry
Parkinson Disease/*drug therapy
Picolinic Acids/*chemistry
Prodrugs/*chemistry
3,4-Dihydroxyphenylacetic Acid/metabolism ; Animals ; Biological Availability ; Carbidopa/chemistry ; Carbidopa/pharmacology ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Dopamine/metabolism ; Drug Combinations ; HeLa Cells ; Humans ; Levodopa/chemical synthesis ; Levodopa/pharmacology ; Male ; Mice, Inbred C57BL ; Monoamine Oxidase/metabolism ; Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/pharmacology ; Permeability ; Picolinic Acids/chemical synthesis ; Picolinic Acids/pharmacology ; Prodrugs/chemical synthesis ; Prodrugs/pharmacology ; Solubility ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Profiling of Heterobranchia Sea Slugs from Portuguese Coastal Waters as Producers of Anti-Cancer and Anti-Inflammatory Agents.
Autorzy:
Gomes NGM; REQUIMTE/LAQV, Laboratory of Pharmacognosy, Departament of Chemistry, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira, no. 228, 4050-313 Porto, Portugal. .
Fernandes F; REQUIMTE/LAQV, Laboratory of Pharmacognosy, Departament of Chemistry, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira, no. 228, 4050-313 Porto, Portugal. .
Madureira-Carvalho Á; REQUIMTE/LAQV, Laboratory of Pharmacognosy, Departament of Chemistry, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira, no. 228, 4050-313 Porto, Portugal. .; IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, University Institute of Health Sciences (IUCS), CESPU, CRL, Central de Gandra Street, 1317, 4585-116 Gandra PRD, Portugal. .
Valentão P; REQUIMTE/LAQV, Laboratory of Pharmacognosy, Departament of Chemistry, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira, no. 228, 4050-313 Porto, Portugal. .
Lobo-da-Cunha A; Departamento de Microscopia, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, 4050-313 Porto, Portugal. .; Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), 4450-208 Matosinhos, Portugal. .
Calado G; Departamento de Ciências da Vida, Universidade Lusófona de Humanidades e Tecnologia, 1749-024 Lisboa, Portugal. .; MARE NOVA. Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Departamento de Ciências e Engenharia do Ambiente, Campus da Caparica, 2829-516 Caparica, Portugal. .
Andrade PB; REQUIMTE/LAQV, Laboratory of Pharmacognosy, Departament of Chemistry, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira, no. 228, 4050-313 Porto, Portugal. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2018 Apr 27; Vol. 23 (5). Date of Electronic Publication: 2018 Apr 27.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Inflammatory Agents/*analysis
Antineoplastic Agents/*analysis
Fatty Acids/*analysis
Gastropoda/*metabolism
Macrophages/*drug effects
Picolinic Acids/*analysis
A549 Cells ; Animals ; Anti-Inflammatory Agents/metabolism ; Antineoplastic Agents/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Fatty Acids/metabolism ; Humans ; Lipopolysaccharides/adverse effects ; Macrophages/cytology ; Macrophages/metabolism ; Mice ; Nitric Oxide/metabolism ; Picolinic Acids/metabolism ; RAW 264.7 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pharmacokinetics and bioavailability of chromium malate and its influence on trace metals absorption after oral or intravenous administration.
Autorzy:
Feng W; Department of Environmental Engineering, School of the Environment and Safety Engineering, Institute of Environmental Health and Ecological Security, Jiangsu, China.
Li Q; Department of Food Science, School of Food and Biological Engineering, Jiangsu University, Jiangsu, China.
Wang W; Department of Food Science, School of Food and Biological Engineering, Jiangsu University, Jiangsu, China.
Zhao T; Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Jiangsu University, Jiangsu, China.
Feng Y; Department of Basic Medicine, School of Medical Science and Laboratory Medicine, Jiangsu University, Jiangsu, China.
Li F; Department of Basic Medicine, School of Medical Science and Laboratory Medicine, Jiangsu University, Jiangsu, China.
Mao G; Department of Environmental Engineering, School of the Environment and Safety Engineering, Institute of Environmental Health and Ecological Security, Jiangsu, China.
Chen Y; Department of Environmental Engineering, School of the Environment and Safety Engineering, Institute of Environmental Health and Ecological Security, Jiangsu, China.
Ding Y; Department of Environmental Engineering, School of the Environment and Safety Engineering, Institute of Environmental Health and Ecological Security, Jiangsu, China.
Yang L; Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Jiangsu University, Jiangsu, China.
Wu X; Department of Environmental Engineering, School of the Environment and Safety Engineering, Institute of Environmental Health and Ecological Security, Jiangsu, China.
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Źródło:
Indian journal of pharmacology [Indian J Pharmacol] 2018 Mar-Apr; Vol. 50 (2), pp. 75-83.
Typ publikacji:
Journal Article
MeSH Terms:
Chlorides/*pharmacokinetics
Chromium Compounds/*pharmacokinetics
Malates/*pharmacokinetics
Metals/*blood
Picolinic Acids/*pharmacokinetics
Administration, Intravenous ; Administration, Oral ; Animals ; Biological Availability ; Chlorides/administration & dosage ; Chromium Compounds/administration & dosage ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Type 2/blood ; Feces/chemistry ; Female ; Malates/administration & dosage ; Male ; Picolinic Acids/administration & dosage ; Rats ; Rats, Sprague-Dawley ; Tissue Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 284

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