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Wyszukujesz frazę ""Picrotoxin"" wg kryterium: Temat


Tytuł :
Biocidal efficacy of tutin and its influence on immune cells and expression of growth-blocking and neuroglian peptides in Mythimna separata (Lepidoptera: Noctuidae).
Autorzy :
Li F; College of Forestry, Northwest A&F University, Yangling, Shaanxi, China.
Cui J; College of Forestry, Northwest A&F University, Yangling, Shaanxi, China.
Shaheen T; College of Forestry, Northwest A&F University, Yangling, Shaanxi, China.
Tang G; College of Forestry, Northwest A&F University, Yangling, Shaanxi, China.
Wang T; Nursing Department, College of Science and Engineering, Southern Arkansas University, Magnolia, Arkansas, USA.
Woolfley T; Nursing Department, College of Science and Engineering, Southern Arkansas University, Magnolia, Arkansas, USA.
Li M; College of Forestry, Northwest A&F University, Yangling, Shaanxi, China.
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Źródło :
Archives of insect biochemistry and physiology [Arch Insect Biochem Physiol] 2021 May; Vol. 107 (1), pp. e21767. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
Insecticides/*pharmacology
Moths/*drug effects
Picrotoxin/*analogs & derivatives
Sesquiterpenes/*pharmacology
Animals ; Cytokines/drug effects ; Cytokines/metabolism ; Hemocytes/drug effects ; Insect Proteins/drug effects ; Insect Proteins/metabolism ; Larva/drug effects ; Larva/growth & development ; Moths/growth & development ; Neuropeptides/drug effects ; Pest Control ; Picrotoxin/pharmacology
Czasopismo naukowe
Tytuł :
Synthesis of (-)-Picrotoxinin by Late-Stage Strong Bond Activation.
Autorzy :
Crossley SWM; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Tong G; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Lambrecht MJ; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Burdge HE; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Shenvi RA; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2020 Jul 01; Vol. 142 (26), pp. 11376-11381. Date of Electronic Publication: 2020 Jun 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Picrotoxin/*analogs & derivatives
Molecular Conformation ; Picrotoxin/chemical synthesis ; Picrotoxin/chemistry ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Investigation of phytochemical constituents of anti-leukemic herbal drugs used by the traditional healers of Purulia, Birbhum and Bankura districts of West Bengal.
Autorzy :
Sarkar MK; Chemical Biology Lab (ASK-II-409), School of Chemical and Biotechnology, SASTRA Deemed to Be University, Thanjavur, Tamilnadu, India.
Vadivel V; Chemical Biology Lab (ASK-II-409), School of Chemical and Biotechnology, SASTRA Deemed to Be University, Thanjavur, Tamilnadu, India.
Raja MRC; Medicinal Chemistry and Immunology Lab (ASK-II-406) School of Chemical and Biotechnology, SASTRA Deemed to Be University, Thanjavur, Tamilnadu, India.
Kar Mahapatra S; Medicinal Chemistry and Immunology Lab (ASK-II-406) School of Chemical and Biotechnology, SASTRA Deemed to Be University, Thanjavur, Tamilnadu, India.
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Źródło :
Natural product research [Nat Prod Res] 2020 Dec; Vol. 34 (23), pp. 3388-3393. Date of Electronic Publication: 2019 Feb 15.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*chemistry
Leukemia/*drug therapy
Phytochemicals/*analysis
Plants, Medicinal/*chemistry
Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Cell Line, Tumor ; Chromatography, Liquid ; Drug Screening Assays, Antitumor ; Humans ; India/ethnology ; Luteolin/analysis ; Medicine, Traditional ; Phytochemicals/pharmacology ; Picrotoxin/analogs & derivatives ; Picrotoxin/analysis ; Plant Extracts/analysis ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus.
Autorzy :
Kwak H; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
Koh W; Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea; Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, South Korea.
Kim S; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
Song K; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
Shin JI; Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Lee JM; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea; Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, South Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, South Korea.
Lee EH; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
Bae JY; Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu 41566, South Korea.
Ha GE; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
Oh JE; Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Park YM; Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea; Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, South Korea.
Kim S; Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, South Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, South Korea.
Feng J; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Lee SE; Virus Facility, Research Animal Resource Center, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Choi JW; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Kim KH; Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Kim YS; Department of Molecular Biology, College of Natural Science, Dankook University, Cheonan 31116, South Korea.
Woo J; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Lee D; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
Son T; School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, South Korea.
Kwon SW; Radiation Medicine Clinical Research Division, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea.
Park KD; Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul 02792, South Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, South Korea.
Yoon BE; Department of Molecular Biology, College of Natural Science, Dankook University, Cheonan 31116, South Korea.
Lee J; Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Li Y; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China.
Lee H; Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Bae YC; Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu 41566, South Korea.
Lee CJ; Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea; Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, South Korea. Electronic address: .
Cheong E; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea; POSTECH Biotech Center, POSTECH, Pohang, South Korea. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Nov 25; Vol. 108 (4), pp. 691-706.e10. Date of Electronic Publication: 2020 Sep 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*physiology
Neural Inhibition/*physiology
Thalamus/*physiology
Touch Perception/*physiology
gamma-Aminobutyric Acid/*physiology
Aldehyde Dehydrogenase 1 Family/metabolism ; Amine Oxidase (Copper-Containing)/metabolism ; Animals ; Astrocytes/metabolism ; Astrocytes/ultrastructure ; Bestrophins/biosynthesis ; Bestrophins/genetics ; Female ; GABA Antagonists ; Immunohistochemistry ; Inhibitory Postsynaptic Potentials/physiology ; Macrolides/pharmacology ; Male ; Mice ; Mice, Knockout ; Microscopy, Electron ; Neurons/metabolism ; Neurons/physiology ; Patch-Clamp Techniques ; Picrotoxin/pharmacology ; Primary Cell Culture ; Pyridazines/pharmacology ; RNA, Small Interfering/pharmacology ; Retinal Dehydrogenase/metabolism ; gamma-Aminobutyric Acid/biosynthesis ; gamma-Aminobutyric Acid/pharmacology
Czasopismo naukowe
Tytuł :
Unmasking inhibition prolongs neuronal function in retinal degeneration mouse model.
Autorzy :
Wang Q; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Banerjee S; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
So C; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Qiu C; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Lam HC; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Tse D; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Völgyi B; Department of Experimental Zoology and Neurobiology, Szentágothai Research Centre, MTA NAP Retinal Electrical Synapses Research Group, University of Pécs, Pécs, Hungary.
Pan F; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong.; The Centre for Eye and Vision Research, Hong Kong.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Nov; Vol. 34 (11), pp. 15282-15299. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neurons/*physiology
Picrotoxin/*pharmacology
Retinal Cone Photoreceptor Cells/*physiology
Retinal Degeneration/*drug therapy
Retinal Ganglion Cells/*drug effects
Retinal Rod Photoreceptor Cells/*physiology
Vision, Ocular/*drug effects
Animals ; Behavior, Animal ; Disease Models, Animal ; Light ; Mice ; Mice, Inbred C57BL ; Neurons/drug effects ; Receptors, GABA-A/metabolism ; Retinal Cone Photoreceptor Cells/drug effects ; Retinal Degeneration/metabolism ; Retinal Degeneration/pathology ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/pathology ; Retinal Rod Photoreceptor Cells/drug effects
Czasopismo naukowe
Tytuł :
Neuron type-specific expression of a mutant KRAS impairs hippocampal-dependent learning and memory.
Autorzy :
Ryu HH; Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Korea.; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, 03080, Korea.
Kang M; Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Korea.; BK21-Plus Biomedical Science Project, Seoul National University College of Medicine, Seoul, 03080, Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
Hwang KD; Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Korea.; BK21-Plus Biomedical Science Project, Seoul National University College of Medicine, Seoul, 03080, Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
Jang HB; Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
Kim SJ; Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Korea.; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, 03080, Korea.; BK21-Plus Biomedical Science Project, Seoul National University College of Medicine, Seoul, 03080, Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
Lee YS; Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Korea. .; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, 03080, Korea. .; BK21-Plus Biomedical Science Project, Seoul National University College of Medicine, Seoul, 03080, Korea. .; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea. .
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Źródło :
Scientific reports [Sci Rep] 2020 Oct 20; Vol. 10 (1), pp. 17730. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
GABAergic Neurons/*physiology
Hippocampus/*physiology
Intellectual Disability/*genetics
Mutation/*genetics
Neurodevelopmental Disorders/*genetics
Proto-Oncogene Proteins p21(ras)/*genetics
Adult ; Animals ; Cells, Cultured ; Disease Models, Animal ; Humans ; Learning ; Memory ; Mice ; Organ Specificity ; Picrotoxin/pharmacology ; Signal Transduction
Czasopismo naukowe
Tytuł :
GABA A receptor signalling mechanisms revealed by structural pharmacology.
Autorzy :
Masiulis S; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK. .
Desai R; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Uchański T; Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium.
Serna Martin I; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Laverty D; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
Karia D; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Malinauskas T; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Zivanov J; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
Pardon E; Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium.
Kotecha A; Materials and Structural Analysis, Thermo Fisher Scientific, Eindhoven, The Netherlands.
Steyaert J; Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium.
Miller KW; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. .
Aricescu AR; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK. .; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. .
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Źródło :
Nature [Nature] 2019 Jan; Vol. 565 (7740), pp. 454-459. Date of Electronic Publication: 2019 Jan 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Alprazolam/*chemistry
Bicuculline/*chemistry
Diazepam/*chemistry
Picrotoxin/*chemistry
Receptors, GABA-A/*chemistry
Receptors, GABA-A/*metabolism
Signal Transduction/*drug effects
Allosteric Regulation/drug effects ; Alprazolam/pharmacology ; Benzodiazepines/chemistry ; Benzodiazepines/pharmacology ; Bicuculline/pharmacology ; Binding, Competitive/drug effects ; Diazepam/pharmacology ; GABA Modulators/chemistry ; GABA Modulators/pharmacology ; Humans ; Ligands ; Models, Molecular ; Nanostructures/chemistry ; Picrotoxin/pharmacology
Czasopismo naukowe
Tytuł :
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Autorzy :
Kim JJ; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Gharpure A; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Teng J; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zhuang Y; Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden.
Howard RJ; Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden.
Zhu S; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Noviello CM; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Walsh RM Jr; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Lindahl E; Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden.; Department of Applied Physics, Swedish e-Science Research Center, KTH Royal Institute of Technology, Solna, Sweden.
Hibbs RE; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA. .
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Źródło :
Nature [Nature] 2020 Sep; Vol. 585 (7824), pp. 303-308. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Anesthetics, General/*chemistry
Anesthetics, General/*pharmacology
Barbiturates/*chemistry
Barbiturates/*pharmacology
Benzodiazepines/*chemistry
Benzodiazepines/*pharmacology
Receptors, GABA-A/*chemistry
Allosteric Regulation/drug effects ; Anesthetics, General/metabolism ; Barbiturates/metabolism ; Benzodiazepines/metabolism ; Bicuculline/chemistry ; Bicuculline/metabolism ; Bicuculline/pharmacology ; Binding Sites ; Binding, Competitive/drug effects ; Diazepam/chemistry ; Diazepam/metabolism ; Diazepam/pharmacology ; Electrophysiology ; Etomidate/chemistry ; Etomidate/metabolism ; Etomidate/pharmacology ; Flumazenil/pharmacology ; GABA-A Receptor Antagonists/chemistry ; GABA-A Receptor Antagonists/metabolism ; GABA-A Receptor Antagonists/pharmacology ; Humans ; Ligands ; Models, Molecular ; Molecular Conformation ; Molecular Dynamics Simulation ; Phenobarbital/chemistry ; Phenobarbital/metabolism ; Phenobarbital/pharmacology ; Picrotoxin/chemistry ; Picrotoxin/metabolism ; Picrotoxin/pharmacology ; Propofol/chemistry ; Propofol/metabolism ; Propofol/pharmacology ; Receptors, GABA-A/metabolism ; Receptors, GABA-A/ultrastructure ; gamma-Aminobutyric Acid/chemistry ; gamma-Aminobutyric Acid/metabolism ; gamma-Aminobutyric Acid/pharmacology
Czasopismo naukowe
Tytuł :
Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14.
Autorzy :
Nowak S; German Institute of Human Nutrition Potsdam-Rehbruecke, Dept. Molecular Genetics, 14558 Nuthetal, Germany.
Di Pizio A; The Institute of Biochemistry, Food and Nutrition, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University, 76100 Rehovot, Israel; The Fritz Haber Center for Molecular Dynamics, The Hebrew University, Jerusalem 91904, Israel.
Levit A; The Institute of Biochemistry, Food and Nutrition, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University, 76100 Rehovot, Israel; The Fritz Haber Center for Molecular Dynamics, The Hebrew University, Jerusalem 91904, Israel; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158-2280, USA.
Niv MY; The Institute of Biochemistry, Food and Nutrition, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University, 76100 Rehovot, Israel; The Fritz Haber Center for Molecular Dynamics, The Hebrew University, Jerusalem 91904, Israel.
Meyerhof W; German Institute of Human Nutrition Potsdam-Rehbruecke, Dept. Molecular Genetics, 14558 Nuthetal, Germany; Center for Integrative Physiology and Molecular Medicine, Saarland University, 66421 Homburg, Germany.
Behrens M; German Institute of Human Nutrition Potsdam-Rehbruecke, Dept. Molecular Genetics, 14558 Nuthetal, Germany; Leibniz-Institute for Food Systems Biology, Technical University of Munich, 85354 Freising, Germany. Electronic address: .
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2018 Oct; Vol. 1862 (10), pp. 2162-2173. Date of Electronic Publication: 2018 Jul 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aristolochic Acids/*metabolism
Monoterpenes/*metabolism
Picrotoxin/*analogs & derivatives
Receptors, G-Protein-Coupled/*chemistry
Receptors, G-Protein-Coupled/*metabolism
Taste/*physiology
Amino Acid Sequence ; Aristolochic Acids/chemistry ; Bicyclic Monoterpenes ; Binding Sites ; Humans ; Ligands ; Models, Molecular ; Molecular Docking Simulation ; Monoterpenes/chemistry ; Mutagenesis, Site-Directed ; Mutation ; Picrotoxin/chemistry ; Picrotoxin/metabolism ; Protein Binding ; Protein Conformation ; Protein Engineering ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/genetics
Czasopismo naukowe
Tytuł :
HAP1 Modulates Epileptic Seizures by Regulating GABA A R Function in Patients with Temporal Lobe Epilepsy and in the PTZ-Induced Epileptic Model.
Autorzy :
Li R; Department of Neurology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Wu B; Department of Neurology, Chongqing Key Laboratory of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
He M; Center for Brain Disorders Research, Capital Medical University, Beijing, China.; Beijing Institute for Brain Disorders, Beijing, China.
Zhang P; Department of Neurology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Zhang Q; Department of Neurology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Deng J; Department of Neurology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Yuan J; Department of Neurology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Chen Y; Department of Neurology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. .
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Źródło :
Neurochemical research [Neurochem Res] 2020 Sep; Vol. 45 (9), pp. 1997-2008. Date of Electronic Publication: 2020 May 17.
Typ publikacji :
Journal Article
MeSH Terms :
Epilepsy, Temporal Lobe/*physiopathology
Nerve Tissue Proteins/*metabolism
Receptors, GABA-A/*metabolism
Adolescent ; Adult ; Animals ; Child ; Child, Preschool ; Epilepsy, Temporal Lobe/chemically induced ; Female ; GABA Antagonists/pharmacology ; Gene Knockout Techniques ; Humans ; Inhibitory Postsynaptic Potentials/physiology ; Male ; Nerve Tissue Proteins/genetics ; Pentylenetetrazole ; Picrotoxin/pharmacology ; Rats, Sprague-Dawley ; Up-Regulation/drug effects ; Young Adult
Czasopismo naukowe
Tytuł :
Synthesis and Evaluation of Anticonvulsant Activity of Some Schiff Bases of 7-Amino-1,3-dihydro-2H-1,4-benzodiazepin-2-one.
Autorzy :
Nilkanth PR; Department of Chemistry, S.S.G.M. College, Kopargaon, Dist-Ahmednagar, Maharashtra, 423601, India.
Ghorai SK; Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, Goa, 403110, India.
Sathiyanarayanan A; Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth, Erandwane, Pune, Maharashtra, 411038, India.
Dhawale K; Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth, Erandwane, Pune, Maharashtra, 411038, India.
Ahamad T; Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Gawande MB; Regional Center of Advanced Technologies and Materials, Faculty of Science, Palacký University, Šlechtitelů 27, 78371, Olomouc, Czech Republic.; Institute of Chemical Technology Mumbai-Marathwada Campus, Jalna, Maharashtra, 431203, India.
Shelke SN; Department of Chemistry, S.S.G.M. College, Kopargaon, Dist-Ahmednagar, Maharashtra, 423601, India.
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Źródło :
Chemistry & biodiversity [Chem Biodivers] 2020 Sep; Vol. 17 (9), pp. e2000342. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article
MeSH Terms :
Anticonvulsants/*pharmacology
Azepines/*pharmacology
Seizures/*drug therapy
Animals ; Anticonvulsants/chemical synthesis ; Anticonvulsants/chemistry ; Azepines/chemical synthesis ; Azepines/chemistry ; Behavior, Animal/drug effects ; Female ; Male ; Models, Molecular ; Molecular Structure ; Picrotoxin/administration & dosage ; Rats ; Rats, Wistar ; Schiff Bases/chemical synthesis ; Schiff Bases/chemistry ; Schiff Bases/pharmacology ; Seizures/chemically induced
Czasopismo naukowe
Tytuł :
Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor.
Autorzy :
Ito D; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, 252-5258, Japan.
Kawazoe Y; Saga University Center for Education and Research in Agricultural Innovation, Karatsu, 847-0021, Japan.
Sato A; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, 464-8601, Japan.
Uesugi M; Institute for Chemical Research (ICR) and Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Uji, 611-0011, Japan.
Hirata H; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, 252-5258, Japan. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 19; Vol. 10 (1), pp. 13999. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Niflumic Acid/*pharmacology
Receptors, Glycine/*antagonists & inhibitors
Synaptic Transmission/*drug effects
Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Convulsants/pharmacology ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/drug effects ; Embryo, Nonmammalian/physiology ; Female ; Glycine/pharmacology ; Membrane Potentials/drug effects ; Nifedipine/pharmacology ; Oocytes/drug effects ; Oocytes/metabolism ; Oocytes/physiology ; Picrotoxin/pharmacology ; Receptors, Glycine/agonists ; Receptors, Glycine/metabolism ; Strychnine/pharmacology ; Synaptic Transmission/physiology ; Vasodilator Agents/pharmacology ; Xenopus laevis ; Zebrafish/embryology ; Zebrafish/metabolism
Czasopismo naukowe
Tytuł :
Electrical coupling controls dimensionality and chaotic firing of inferior olive neurons.
Autorzy :
Hoang H; Computational Neuroscience Laboratories, ATR Institute International, Kyoto, Japan.
Lang EJ; Department of Neuroscience and Physiology, New York University School of Medicine, New York, New York, United States of America.
Hirata Y; Institute of Industrial Science, The University of Tokyo, Tokyo, Japan.; Mathematics and Informatics Center, The University of Tokyo, Tokyo, Japan.; International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo, Tokyo, Japan.
Tokuda IT; Department of Mechanical Engineering, Ritsumeikan University, Shiga, Japan.
Aihara K; Institute of Industrial Science, The University of Tokyo, Tokyo, Japan.; International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo, Tokyo, Japan.
Toyama K; Computational Neuroscience Laboratories, ATR Institute International, Kyoto, Japan.
Kawato M; Computational Neuroscience Laboratories, ATR Institute International, Kyoto, Japan.; RIKEN Center for Advanced Intelligence Project, ATR Institute International, Kyoto, Japan.
Schweighofer N; Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, United States of America.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Jul 30; Vol. 16 (7), pp. e1008075. Date of Electronic Publication: 2020 Jul 30 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Neurons/*physiology
Olivary Nucleus/*physiology
Action Potentials ; Animals ; Bayes Theorem ; Cerebellum/physiology ; Computer Simulation ; Female ; Gap Junctions/physiology ; Models, Neurological ; Models, Statistical ; Nonlinear Dynamics ; Picrotoxin/pharmacology ; Probability ; Purkinje Cells/physiology ; Rats ; Rats, Sprague-Dawley ; Synapses/physiology ; gamma-Aminobutyric Acid/physiology
Czasopismo naukowe
Tytuł :
Spontaneous and evoked neurotransmission are partially segregated at inhibitory synapses.
Autorzy :
Horvath PM; Department of Pharmacology, Vanderbilt University, Nashville, United States.; Department of Neuroscience, the University of Texas Southwestern Medical Center, Dallas, United States.
Piazza MK; Vanderbilt Brain Institute, Vanderbilt University, Nashville, United States.; Neuroscience Program, Vanderbilt University, Nashville, United States.
Monteggia LM; Department of Pharmacology, Vanderbilt University, Nashville, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, United States.
Kavalali ET; Department of Pharmacology, Vanderbilt University, Nashville, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, United States.
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Źródło :
ELife [Elife] 2020 May 13; Vol. 9. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Inhibitory Postsynaptic Potentials*/drug effects
Neural Inhibition*/drug effects
Synaptic Transmission*/drug effects
GABAergic Neurons/*physiology
Hippocampus/*physiology
Animals ; Cells, Cultured ; Electric Stimulation ; Female ; GABA Antagonists/pharmacology ; GABAergic Neurons/drug effects ; GABAergic Neurons/metabolism ; Hippocampus/cytology ; Hippocampus/drug effects ; Hippocampus/metabolism ; In Vitro Techniques ; Picrotoxin/pharmacology ; Rats, Sprague-Dawley ; Receptors, GABA-A/metabolism
Czasopismo naukowe
Tytuł :
Glycosides of the Neurotoxin Tutin in Toxic Honeys Are from Coriaria arborea Phloem Sap, Not Insect Metabolism.
Autorzy :
Watkins OC; Department of Chemistry , University of Otago , P.O. Box 56, Dunedin , New Zealand.
Joyce NI; The New Zealand Institute for Plant & Food Research Limited , Private Bag 4704, Christchurch , New Zealand.
Gould N; The New Zealand Institute for Plant & Food Research Limited , RD 2, Te Puke , New Zealand.
Perry NB; The New Zealand Institute for Plant & Food Research Limited, Department of Chemistry, University of Otago , P.O. Box 56, Dunedin , New Zealand.
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Źródło :
Journal of natural products [J Nat Prod] 2018 Apr 27; Vol. 81 (4), pp. 1116-1120. Date of Electronic Publication: 2018 Mar 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glycosides/*chemistry
Insecta/*chemistry
Magnoliopsida/*chemistry
Neurotoxins/*chemistry
Phloem/*chemistry
Picrotoxin/*analogs & derivatives
Sesquiterpenes/*chemistry
Animals ; Chromatography, Liquid/methods ; Honey ; Picrotoxin/chemistry ; Plant Leaves/chemistry ; Tandem Mass Spectrometry/methods
Czasopismo naukowe
Tytuł :
Poisoning due to tutin in honey-a report of an outbreak in New Zealand.
Autorzy :
Beasley M; National Poisons Centre, University of Otago, Dunedin.
Hood D; Formerly Waikato District Health Board, Hamilton.
Anderson P; Counties Manukau District Health Board, Auckland.
Reeve J; New Zealand Ministry for Primary Industries, Wellington.
Slaughter RJ; National Poisons Centre, University of Otago, Dunedin.
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Źródło :
The New Zealand medical journal [N Z Med J] 2018 Apr 13; Vol. 131 (1473), pp. 59-71. Date of Electronic Publication: 2018 Apr 13.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Honey*
Picrotoxin/*analogs & derivatives
Poisoning/*epidemiology
Sesquiterpenes/*poisoning
Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Disease Outbreaks/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; New Zealand/epidemiology ; Picrotoxin/poisoning ; Retrospective Studies ; Young Adult
Czasopismo naukowe
Tytuł :
Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists.
Autorzy :
Bandara SB; Department of Molecular Biosciences, University of California, Davis, School of Veterinary Medicine, Davis, CA 95616, United States. Electronic address: .
Carty DR; Department of Molecular Biosciences, University of California, Davis, School of Veterinary Medicine, Davis, CA 95616, United States. Electronic address: .
Singh V; Department of Pharmacology, University of California, Davis, School of Medicine, Davis, CA 95616, United States. Electronic address: .
Harvey DJ; Department of Public Health Sciences, University of California, Davis, School of Medicine, Davis, CA 95616, United States. Electronic address: .
Vasylieva N; Department of Entomology, University of California, Davis, College of Agricultural and Environmental Sciences, Davis, CA 95616, United States. Electronic address: .
Pressly B; Department of Pharmacology, University of California, Davis, School of Medicine, Davis, CA 95616, United States. Electronic address: .
Wulff H; Department of Pharmacology, University of California, Davis, School of Medicine, Davis, CA 95616, United States. Electronic address: .
Lein PJ; Department of Molecular Biosciences, University of California, Davis, School of Veterinary Medicine, Davis, CA 95616, United States. Electronic address: .
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Źródło :
Neurotoxicology [Neurotoxicology] 2020 Jan; Vol. 76, pp. 220-234. Date of Electronic Publication: 2019 Dec 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Brain/*drug effects
Drug Evaluation, Preclinical/*methods
GABA-A Receptor Antagonists/*toxicity
Seizures/*chemically induced
Animals ; Brain/physiopathology ; Bridged-Ring Compounds/toxicity ; Pentylenetetrazole/toxicity ; Picrotoxin/toxicity ; Seizures/physiopathology ; Zebrafish
Czasopismo naukowe
Tytuł :
Using Toxins in Brain Slice Recordings.
Autorzy :
Bingor A; Faculty of Medicine, School of Pharmacy, Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
Yaka R; Faculty of Medicine, School of Pharmacy, Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2020; Vol. 2068, pp. 269-274.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*drug effects
Brain/*metabolism
Animals ; Electrophysiology/methods ; In Vitro Techniques ; Ion Channels/metabolism ; Mice ; Patch-Clamp Techniques ; Picrotoxin/pharmacology ; Rats ; Tetrodotoxin/pharmacology
Czasopismo naukowe
Tytuł :
Effects of bilobalide, ginkgolide B and picrotoxinin on GABA A receptor modulation by structurally diverse positive modulators.
Autorzy :
Ng CC; Adrien Albert Laboratory of Medicinal Chemistry, Pharmacology, School of Medical Sciences, The University of Sydney, NSW 2006, Australia.
Duke RK; Adrien Albert Laboratory of Medicinal Chemistry, Pharmacology, School of Medical Sciences, The University of Sydney, NSW 2006, Australia.
Hinton T; Adrien Albert Laboratory of Medicinal Chemistry, Pharmacology, School of Medical Sciences, The University of Sydney, NSW 2006, Australia.
Johnston GAR; Adrien Albert Laboratory of Medicinal Chemistry, Pharmacology, School of Medical Sciences, The University of Sydney, NSW 2006, Australia. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2017 Jul 05; Vol. 806, pp. 83-90. Date of Electronic Publication: 2017 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclopentanes/*pharmacology
Furans/*pharmacology
GABA Modulators/*chemistry
GABA Modulators/*pharmacology
Ginkgolides/*pharmacology
Lactones/*pharmacology
Picrotoxin/*analogs & derivatives
Receptors, GABA-A/*metabolism
Animals ; Dose-Response Relationship, Drug ; Electrophysiological Phenomena/drug effects ; Ginkgo biloba/chemistry ; Humans ; Picrotoxin/pharmacology ; Terpenes/chemistry ; Terpenes/pharmacology ; Xenopus laevis
Czasopismo naukowe

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