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Title:
Downregulation of Ribosomal Protein Genes Is Revealed in a Model of Rat Hippocampal Neuronal Culture Activation with GABA(A)R/GlyRa2 Antagonist Picrotoxin.
Authors:
Beletskiy A; Institute of Higher Nervous Activity and Neurophysiology, The Russian Academy of Sciences, 117485 Moscow, Russia.
Zolotar A; Institute of Higher Nervous Activity and Neurophysiology, The Russian Academy of Sciences, 117485 Moscow, Russia.
Fortygina P; Institute of Higher Nervous Activity and Neurophysiology, The Russian Academy of Sciences, 117485 Moscow, Russia.
Chesnokova E; Institute of Higher Nervous Activity and Neurophysiology, The Russian Academy of Sciences, 117485 Moscow, Russia.
Uroshlev L; Institute of Higher Nervous Activity and Neurophysiology, The Russian Academy of Sciences, 117485 Moscow, Russia.
Balaban P; Institute of Higher Nervous Activity and Neurophysiology, The Russian Academy of Sciences, 117485 Moscow, Russia.
Kolosov P; Institute of Higher Nervous Activity and Neurophysiology, The Russian Academy of Sciences, 117485 Moscow, Russia.; Engelhardt Institute of Molecular Biology, The Russian Academy of Sciences, 119991 Moscow, Russia.
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Source:
Cells [Cells] 2024 Feb 23; Vol. 13 (5). Date of Electronic Publication: 2024 Feb 23.
Publication Type:
Journal Article
MeSH Terms:
Ribosomal Proteins*
Hippocampus*
Rats ; Animals ; Picrotoxin ; GABA Antagonists ; Down-Regulation ; RNA, Messenger ; gamma-Aminobutyric Acid
Academic Journal
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Title:
Sweet poison: seizures in two patients with Coriaria intermedia poisoning.
Authors:
Chen YC; Department of Emergency Medicine, China Medical University Hospital, Hsinchu, Taiwan.; Department of Public Health, China Medical University, Taichung, Taiwan.
Chen HY; Department of Emergency Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Huang LC; School of Nursing, China Medical University Hospital, Taichung, Taiwan.
Yu JH; Department of Emergency Medicine, China Medical University Hospital, Hsinchu, Taiwan.
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Source:
Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2021 Jun; Vol. 59 (6), pp. 533-534. Date of Electronic Publication: 2020 Oct 28.
Publication Type:
Case Reports; Letter
MeSH Terms:
Picrotoxin/*analogs & derivatives
Plants, Toxic/*poisoning
Seizures/*chemically induced
Sesquiterpenes/*poisoning
Adult ; Female ; Humans ; Picrotoxin/poisoning
Report
Full Text  Link opens in a new windowDetails
Title:
Functional Deficiency of Interneurons and Negative BOLD fMRI Response.
Authors:
Aksenov DP; Department of Radiology, NorthShore University HealthSystem, Evanston, IL 60201, USA.; Department of Anesthesiology, NorthShore University HealthSystem, Evanston, IL 60201, USA.; Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Li L; Department of Radiology, NorthShore University HealthSystem, Evanston, IL 60201, USA.
Serdyukova NA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.; Department of Pediatrics, NorthShore University HealthSystem, Evanston, IL 60201, USA.
Gascoigne DA; Department of Radiology, NorthShore University HealthSystem, Evanston, IL 60201, USA.
Doubovikov ED; Department of Radiology, NorthShore University HealthSystem, Evanston, IL 60201, USA.
Drobyshevsky A; Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.; Department of Pediatrics, NorthShore University HealthSystem, Evanston, IL 60201, USA.
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Source:
Cells [Cells] 2023 Mar 06; Vol. 12 (5). Date of Electronic Publication: 2023 Mar 06.
Publication Type:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Magnetic Resonance Imaging*
Interneurons*
Animals ; Rabbits ; Picrotoxin ; Neurons/physiology ; Oxygen
Academic Journal
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Title:
The dependence of acetylcholine on dynamic changes in the membrane potential and an action potential during spike timing-dependent plasticity induction in the hippocampus.
Authors:
Sugisaki E; Brain Science Institute, Tamagawa University, Tokyo, Japan.
Fukushima Y; Brain Science Institute, Tamagawa University, Tokyo, Japan.; Kawasaki University of Medical Welfare, Okayama, Japan.
Nakajima N; Graduated School of Engineering, Tamagawa University, Tokyo, Japan.
Aihara T; Brain Science Institute, Tamagawa University, Tokyo, Japan.
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Source:
The European journal of neuroscience [Eur J Neurosci] 2022 Dec; Vol. 56 (11), pp. 5972-5986. Date of Electronic Publication: 2022 Oct 05.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetylcholine*
Neurons*/physiology
Action Potentials/physiology ; Membrane Potentials ; Patch-Clamp Techniques ; Picrotoxin/pharmacology ; Hippocampus/physiology
Academic Journal
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Title:
Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures.
Authors:
Olubodun-Obadun TG; Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
Ishola IO; Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
Ben-Azu B; Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, Delta State University, Abraka, Nigeria.
Afolayan O; Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Abraka, Nigeria.
Nwose E; Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
James AB; Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
Ajayi AM; Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, Delta State University, Abraka, Nigeria.
Umukoro S; Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, Delta State University, Abraka, Nigeria.
Adeyemi OO; Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
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Source:
Journal of food biochemistry [J Food Biochem] 2022 Oct; Vol. 46 (10), pp. e14342. Date of Electronic Publication: 2022 Jul 19.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Clerodendrum*/metabolism
Lamiaceae*
Animals ; Anticonvulsants/pharmacology ; Antioxidants/therapeutic use ; Arginine ; Cyclooxygenase 2/metabolism ; Flumazenil ; Guanosine Monophosphate ; Kainic Acid ; Methylene Blue ; Mice ; NF-kappa B/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type I/metabolism ; Pentylenetetrazole ; Picrotoxin ; Plant Extracts/pharmacology ; Receptors, GABA-A/therapeutic use ; Seizures/chemically induced ; Seizures/drug therapy ; Soluble Guanylyl Cyclase/metabolism ; Spasm/drug therapy
Academic Journal
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Title:
GABA A Receptor-Stabilizing Protein Ubqln1 Affects Hyperexcitability and Epileptogenesis after Traumatic Brain Injury and in a Model of In Vitro Epilepsy in Mice.
Authors:
Kürten T; Institute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, 55128 Mainz, Germany.
Ihbe N; Institute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, 55128 Mainz, Germany.
Ueberbach T; Institute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, 55128 Mainz, Germany.
Distler U; Institute for Immunology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Sielaff M; Institute for Immunology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Tenzer S; Institute for Immunology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Mittmann T; Institute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, 55128 Mainz, Germany.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2022 Mar 31; Vol. 23 (7). Date of Electronic Publication: 2022 Mar 31.
Publication Type:
Journal Article
MeSH Terms:
Brain Injuries, Traumatic*/complications
Epilepsy*/etiology
Epilepsy*/metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Disease Models, Animal ; Mice ; Picrotoxin ; Receptors, GABA-A/metabolism ; Seizures
Academic Journal
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Title:
GABA A Receptor-Mediated Sleep-Promoting Effect of Saaz-Saphir Hops Mixture Containing Xanthohumol and Humulone.
Authors:
Min B; Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul 02841, Korea.; Lotte R&D Center, Seoul 07594, Korea.
Ahn Y; Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul 02841, Korea.
Cho HJ; Lotte R&D Center, Seoul 07594, Korea.
Kwak WK; Lotte R&D Center, Seoul 07594, Korea.
Suh HJ; Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul 02841, Korea.; Transdisciplinary Major in Learning Health Systems, Graduate School, Korea University, Seoul 02841, Korea.
Jo K; Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul 02841, Korea.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2021 Nov 24; Vol. 26 (23). Date of Electronic Publication: 2021 Nov 24.
Publication Type:
Journal Article
MeSH Terms:
Cyclohexenes/*pharmacology
Flavonoids/*pharmacology
Humulus/*chemistry
Propiophenones/*pharmacology
Receptors, GABA-A/*genetics
Sleep Initiation and Maintenance Disorders/*drug therapy
Terpenes/*pharmacology
Acids/chemistry ; Animals ; Bicuculline/pharmacology ; Caffeine/adverse effects ; Cyclohexenes/chemistry ; Disease Models, Animal ; Electroencephalography ; Flavonoids/chemistry ; GABA-A Receptor Agonists/chemistry ; GABA-A Receptor Agonists/pharmacology ; Humans ; Hypnotics and Sedatives/chemistry ; Hypnotics and Sedatives/pharmacology ; Mice ; Picrotoxin/pharmacology ; Propiophenones/chemistry ; Sleep/drug effects ; Sleep/physiology ; Sleep Initiation and Maintenance Disorders/chemically induced ; Sleep Initiation and Maintenance Disorders/pathology ; Terpenes/chemistry ; gamma-Aminobutyric Acid/genetics
Academic Journal
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Title:
Agonist and antagonist properties of an insect GABA-gated chloride channel (RDL) are influenced by heterologous expression conditions.
Authors:
Smelt CLC; Division of Biosciences, University College London, London, United Kingdom.
Sanders VR; Division of Biosciences, University College London, London, United Kingdom.
Puinean AM; Division of Biosciences, University College London, London, United Kingdom.
Lansdell SJ; Division of Biosciences, University College London, London, United Kingdom.
Goodchild J; Syngenta, Jealotts Hill International Research Centre, Bracknell, Berkshire, United Kingdom.
Millar NS; Division of Biosciences, University College London, London, United Kingdom.
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Source:
PloS one [PLoS One] 2021 Jul 07; Vol. 16 (7), pp. e0254251. Date of Electronic Publication: 2021 Jul 07 (Print Publication: 2021).
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chloride Channels/*antagonists & inhibitors
Chloride Channels/*metabolism
Drosophila melanogaster/*metabolism
gamma-Aminobutyric Acid/*metabolism
3' Untranslated Regions/drug effects ; Amino Acid Sequence ; Animals ; Bees/metabolism ; Chloride Channel Agonists/pharmacology ; Drosophila Proteins/metabolism ; Drosophila melanogaster/drug effects ; Female ; Picrotoxin/analogs & derivatives ; Picrotoxin/pharmacology ; Propofol/pharmacology ; Receptors, Glycine/metabolism ; Sesterterpenes ; Xenopus laevis/metabolism
Academic Journal
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Title:
The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain.
Authors:
Yoon SH; Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.; Neuroscience Research Institute, Seoul National University Medical Research Center, Seoul, 03080, Korea.
Song WS; Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.; Neuroscience Research Institute, Seoul National University Medical Research Center, Seoul, 03080, Korea.
Oh SP; Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
Kim YS; Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
Kim MH; Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea. .; Neuroscience Research Institute, Seoul National University Medical Research Center, Seoul, 03080, Korea. .; Seoul National University Bundang Hospital, Seongnam, 13620, Gyeonggi, Korea. .
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Source:
Molecular brain [Mol Brain] 2021 Sep 15; Vol. 14 (1), pp. 142. Date of Electronic Publication: 2021 Sep 15.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain/*physiology
Eukaryotic Initiation Factor-2/*metabolism
Nerve Tissue Proteins/*metabolism
Animals ; CA3 Region, Hippocampal/metabolism ; Genes, Reporter ; Mice ; Muscimol/pharmacology ; Phosphorylation/drug effects ; Picrotoxin/pharmacology ; Prosencephalon/metabolism ; Protein Processing, Post-Translational/drug effects ; Pyramidal Cells/metabolism ; Quinoxalines/pharmacology ; Restraint, Physical ; Stress, Physiological/physiology ; Strychnine/analogs & derivatives ; Strychnine/pharmacology
Academic Journal
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Title:
Anxiolytic effect of GABAergic neurons in the anterior cingulate cortex in a rat model of chronic inflammatory pain.
Authors:
Shao FB; Department of Neurobiology and Acupuncture Research, the Third School of Clinical Medicine, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, 310053, China.
Fang JF; Department of Neurobiology and Acupuncture Research, the Third School of Clinical Medicine, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, 310053, China.
Wang SS; Department of Neurobiology and Acupuncture Research, the Third School of Clinical Medicine, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, 310053, China.
Qiu MT; Department of Neurobiology and Acupuncture Research, the Third School of Clinical Medicine, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, 310053, China.
Xi DN; Department of Neurobiology and Acupuncture Research, the Third School of Clinical Medicine, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, 310053, China.
Jin XM; Department of Anatomy and Cell Biology, Stark Neurosciences Research Institute, Indiana University School of Medicine, NB Building, 320w 15th Street #141, Indianapolis, IN, 46202, USA.
Liu JG; Department of Neurobiology and Acupuncture Research, the Third School of Clinical Medicine, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, 310053, China.; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Shao XM; Department of Neurobiology and Acupuncture Research, the Third School of Clinical Medicine, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, 310053, China.
Shen Z; Department of Neurobiology and Acupuncture Research, the Third School of Clinical Medicine, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, 310053, China.
Liang Y; Department of Neurobiology and Acupuncture Research, the Third School of Clinical Medicine, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, 310053, China.
Fang JQ; Department of Neurobiology and Acupuncture Research, the Third School of Clinical Medicine, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, 310053, China. .
Du JY; Department of Neurobiology and Acupuncture Research, the Third School of Clinical Medicine, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, 310053, China. .
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Source:
Molecular brain [Mol Brain] 2021 Sep 10; Vol. 14 (1), pp. 139. Date of Electronic Publication: 2021 Sep 10.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anxiety/*physiopathology
Chronic Pain/*physiopathology
GABAergic Neurons/*physiology
Gyrus Cinguli/*physiopathology
Inflammation/*psychology
Pyramidal Cells/*physiology
Animals ; Anti-Anxiety Agents/administration & dosage ; Anti-Anxiety Agents/pharmacology ; Anti-Anxiety Agents/therapeutic use ; Anxiety/drug therapy ; Anxiety/etiology ; Central Nervous System Sensitization/drug effects ; Chronic Pain/psychology ; Clozapine/therapeutic use ; Freund's Adjuvant/toxicity ; GABA-A Receptor Agonists/administration & dosage ; GABA-A Receptor Agonists/pharmacology ; GABA-A Receptor Agonists/therapeutic use ; GABA-A Receptor Antagonists/administration & dosage ; GABA-A Receptor Antagonists/pharmacology ; GABA-A Receptor Antagonists/toxicity ; GABAergic Neurons/enzymology ; Genetic Vectors/pharmacology ; Inflammation/chemically induced ; Inflammation/physiopathology ; Injections ; Interneurons/drug effects ; Male ; Muscimol/administration & dosage ; Muscimol/pharmacology ; Muscimol/therapeutic use ; Open Field Test ; Pain Threshold/drug effects ; Patch-Clamp Techniques ; Picrotoxin/toxicity ; Presynaptic Terminals/drug effects ; Presynaptic Terminals/physiology ; Pyramidal Cells/enzymology ; Rats ; Rats, Sprague-Dawley
Academic Journal
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Title:
Effects of Tempol on Epileptic Activity in Picrotoxin-Induced Epilepsy in Rats.
Authors:
Pinar N; Department of Pharmacology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
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Source:
Neurology India [Neurol India] 2021 Mar-Apr; Vol. 69 (2), pp. 426-429.
Publication Type:
Journal Article
MeSH Terms:
Epilepsy*/chemically induced
Epilepsy*/drug therapy
Animals ; Cyclic N-Oxides ; Disease Models, Animal ; Male ; Picrotoxin/toxicity ; Rats ; Rats, Wistar ; Seizures/chemically induced ; Seizures/drug therapy ; Spin Labels
Academic Journal
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Title:
Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice.
Authors:
Hasebe S; Department of Pharmacology, Graduate School of Dentistry, Osaka University, Osaka, Japan.
Ago Y; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Watabe Y; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Oka S; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Hiramatsu N; Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Tanaka T; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Umehara C; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Hashimoto H; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan.; Division of Bioscience, Institute for Datability Science, Osaka University, Osaka, Japan.
Takuma K; Department of Pharmacology, Graduate School of Dentistry, Osaka University, Osaka, Japan.; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan.
Matsuda T; Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
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Source:
British journal of pharmacology [Br J Pharmacol] 2017 Feb; Vol. 174 (4), pp. 314-327. Date of Electronic Publication: 2017 Jan 26.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anhedonia/*drug effects
Picrotoxin/*pharmacology
Receptors, sigma/*metabolism
Selective Serotonin Reuptake Inhibitors/*pharmacology
Animals ; Dose-Response Relationship, Drug ; Female ; Male ; Mice ; Picrotoxin/chemistry ; Receptors, sigma/agonists ; Receptors, sigma/antagonists & inhibitors ; Selective Serotonin Reuptake Inhibitors/chemistry ; Structure-Activity Relationship ; Sigma-1 Receptor
Academic Journal
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Title:
The Anticonvulsant Effect of Hydroethanolic Leaf Extract of Calotropis procera (Ait) R. Br. (Apocynaceae).
Authors:
Obese E; School of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Biney RP; School of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Henneh IT; School of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Adakudugu EA; School of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Anokwah D; School of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Agyemang LS; Department of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Woode E; Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Allied Health Sciences, Ho, Ghana.
Ameyaw EO; School of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
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Source:
Neural plasticity [Neural Plast] 2021 Jun 26; Vol. 2021, pp. 5566890. Date of Electronic Publication: 2021 Jun 26 (Print Publication: 2021).
Publication Type:
Journal Article
MeSH Terms:
Anticonvulsants/*therapeutic use
Calotropis/*chemistry
Plant Extracts/*therapeutic use
Plant Leaves/*chemistry
Seizures/*drug therapy
Status Epilepticus/*drug therapy
Animals ; Anticonvulsants/isolation & purification ; Chromatography, High Pressure Liquid ; Convulsants/toxicity ; Diazepam/therapeutic use ; Drug Evaluation, Preclinical ; Ethanol ; Female ; Flumazenil/therapeutic use ; Isoniazid/toxicity ; Male ; Mice ; Mice, Inbred ICR ; Phytotherapy ; Picrotoxin/toxicity ; Pilocarpine/toxicity ; Plant Extracts/isolation & purification ; Receptors, GABA-A/physiology ; Seizures/chemically induced ; Solvents ; Strychnine/toxicity ; Water
Academic Journal
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Title:
Atypical electrophysiological and behavioral responses to diazepam in a leading mouse model of Down syndrome.
Authors:
Victorino DB; Discipline of Neuroscience, Department of Neurology and Neurosurgery, Federal University of São Paulo, Paulista Medical School, São Paulo, SP, Brazil.; Division of Pediatric Neurology, Department of Pediatrics, Case Western Reserve University, 11100 Euclid Avenue, Mail Stop RBC 6090, Cleveland, OH, 44106-6090, USA.
Pinheiro DJLL; Discipline of Neuroscience, Department of Neurology and Neurosurgery, Federal University of São Paulo, Paulista Medical School, São Paulo, SP, Brazil.
Scott-McKean JJ; Division of Pediatric Neurology, Department of Pediatrics, Case Western Reserve University, 11100 Euclid Avenue, Mail Stop RBC 6090, Cleveland, OH, 44106-6090, USA.
Barker S; Division of Pediatric Neurology, Department of Pediatrics, Case Western Reserve University, 11100 Euclid Avenue, Mail Stop RBC 6090, Cleveland, OH, 44106-6090, USA.
Stasko MR; Division of Pediatric Neurology, Department of Pediatrics, Case Western Reserve University, 11100 Euclid Avenue, Mail Stop RBC 6090, Cleveland, OH, 44106-6090, USA.
Faber J; Discipline of Neuroscience, Department of Neurology and Neurosurgery, Federal University of São Paulo, Paulista Medical School, São Paulo, SP, Brazil.
Scorza CA; Discipline of Neuroscience, Department of Neurology and Neurosurgery, Federal University of São Paulo, Paulista Medical School, São Paulo, SP, Brazil.
Costa ACS; Division of Pediatric Neurology, Department of Pediatrics, Case Western Reserve University, 11100 Euclid Avenue, Mail Stop RBC 6090, Cleveland, OH, 44106-6090, USA. .; Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA. .
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Source:
Scientific reports [Sci Rep] 2021 May 04; Vol. 11 (1), pp. 9521. Date of Electronic Publication: 2021 May 04.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diazepam/*pharmacology
Down Syndrome/*drug therapy
Electrophysiological Phenomena/*drug effects
Animals ; Disease Models, Animal ; Female ; Long-Term Potentiation/drug effects ; Male ; Maze Learning/drug effects ; Memory Disorders/drug therapy ; Mice ; Mice, Inbred C57BL ; Neuronal Plasticity/drug effects ; Picrotoxin/pharmacology ; Seizures/chemically induced ; Synaptic Transmission/drug effects
Academic Journal
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Title:
Neuron type-specific expression of a mutant KRAS impairs hippocampal-dependent learning and memory.
Authors:
Ryu HH; Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Korea.; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, 03080, Korea.
Kang M; Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Korea.; BK21-Plus Biomedical Science Project, Seoul National University College of Medicine, Seoul, 03080, Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
Hwang KD; Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Korea.; BK21-Plus Biomedical Science Project, Seoul National University College of Medicine, Seoul, 03080, Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
Jang HB; Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
Kim SJ; Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Korea.; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, 03080, Korea.; BK21-Plus Biomedical Science Project, Seoul National University College of Medicine, Seoul, 03080, Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
Lee YS; Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Korea. .; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, 03080, Korea. .; BK21-Plus Biomedical Science Project, Seoul National University College of Medicine, Seoul, 03080, Korea. .; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea. .
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Source:
Scientific reports [Sci Rep] 2020 Oct 20; Vol. 10 (1), pp. 17730. Date of Electronic Publication: 2020 Oct 20.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
GABAergic Neurons/*physiology
Hippocampus/*physiology
Intellectual Disability/*genetics
Mutation/*genetics
Neurodevelopmental Disorders/*genetics
Proto-Oncogene Proteins p21(ras)/*genetics
Adult ; Animals ; Cells, Cultured ; Disease Models, Animal ; Humans ; Learning ; Memory ; Mice ; Organ Specificity ; Picrotoxin/pharmacology ; Signal Transduction
Academic Journal
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Title:
Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor.
Authors:
Ito D; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, 252-5258, Japan.
Kawazoe Y; Saga University Center for Education and Research in Agricultural Innovation, Karatsu, 847-0021, Japan.
Sato A; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, 464-8601, Japan.
Uesugi M; Institute for Chemical Research (ICR) and Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Uji, 611-0011, Japan.
Hirata H; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, 252-5258, Japan. .
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Source:
Scientific reports [Sci Rep] 2020 Aug 19; Vol. 10 (1), pp. 13999. Date of Electronic Publication: 2020 Aug 19.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Niflumic Acid/*pharmacology
Receptors, Glycine/*antagonists & inhibitors
Synaptic Transmission/*drug effects
Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Convulsants/pharmacology ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/drug effects ; Embryo, Nonmammalian/physiology ; Female ; Glycine/pharmacology ; Membrane Potentials/drug effects ; Nifedipine/pharmacology ; Oocytes/drug effects ; Oocytes/metabolism ; Oocytes/physiology ; Picrotoxin/pharmacology ; Receptors, Glycine/agonists ; Receptors, Glycine/metabolism ; Strychnine/pharmacology ; Synaptic Transmission/physiology ; Vasodilator Agents/pharmacology ; Xenopus laevis ; Zebrafish/embryology ; Zebrafish/metabolism
Academic Journal
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Title:
Alleviating toxic α-Synuclein accumulation by membrane depolarization: evidence from an in vitro model of Parkinson's disease.
Authors:
Ross A; Department of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Xing V; Department of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Wang TT; Department of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Bureau SC; Department of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Link GA; Department of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Fortin T; Department of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Zhang H; Department of Neurology, SUNY Downstate Medical center, Brooklyn, NY, 11226, USA.
Hayley S; Department of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada. .
Sun H; Department of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada. .
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Source:
Molecular brain [Mol Brain] 2020 Jul 31; Vol. 13 (1), pp. 108. Date of Electronic Publication: 2020 Jul 31.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Biological*
Membrane Potentials/*drug effects
Parkinson Disease/*physiopathology
alpha-Synuclein/*toxicity
Amyloid/metabolism ; Cell Death/drug effects ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Electric Stimulation ; Humans ; Picrotoxin ; Potassium Chloride
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
Electrical coupling controls dimensionality and chaotic firing of inferior olive neurons.
Authors:
Hoang H; Computational Neuroscience Laboratories, ATR Institute International, Kyoto, Japan.
Lang EJ; Department of Neuroscience and Physiology, New York University School of Medicine, New York, New York, United States of America.
Hirata Y; Institute of Industrial Science, The University of Tokyo, Tokyo, Japan.; Mathematics and Informatics Center, The University of Tokyo, Tokyo, Japan.; International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo, Tokyo, Japan.
Tokuda IT; Department of Mechanical Engineering, Ritsumeikan University, Shiga, Japan.
Aihara K; Institute of Industrial Science, The University of Tokyo, Tokyo, Japan.; International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo, Tokyo, Japan.
Toyama K; Computational Neuroscience Laboratories, ATR Institute International, Kyoto, Japan.
Kawato M; Computational Neuroscience Laboratories, ATR Institute International, Kyoto, Japan.; RIKEN Center for Advanced Intelligence Project, ATR Institute International, Kyoto, Japan.
Schweighofer N; Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, United States of America.
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Source:
PLoS computational biology [PLoS Comput Biol] 2020 Jul 30; Vol. 16 (7), pp. e1008075. Date of Electronic Publication: 2020 Jul 30 (Print Publication: 2020).
Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Neurons/*physiology
Olivary Nucleus/*physiology
Action Potentials ; Animals ; Bayes Theorem ; Cerebellum/physiology ; Computer Simulation ; Female ; Gap Junctions/physiology ; Models, Neurological ; Models, Statistical ; Nonlinear Dynamics ; Picrotoxin/pharmacology ; Probability ; Purkinje Cells/physiology ; Rats ; Rats, Sprague-Dawley ; Synapses/physiology ; gamma-Aminobutyric Acid/physiology
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
Presynaptic glutamatergic transmission and feedback system of oxytocinergic neurons in the hypothalamus of a rat model of adjuvant arthritis.
Authors:
Fujitani T; Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Matsuura T; Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.; Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kawasaki M; Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Suzuki H; Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Nishimura H; Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Baba K; Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yamanaka Y; Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Ohnishi H; Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Ueta Y; Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Sakai A; Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
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Source:
Molecular pain [Mol Pain] 2020 Jan-Dec; Vol. 16, pp. 1744806920943334.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Feedback*
Synaptic Transmission*/drug effects
Arthritis, Experimental/*metabolism
Glutamates/*metabolism
Hypothalamus/*metabolism
Neurons/*metabolism
Oxytocin/*metabolism
Presynaptic Terminals/*metabolism
Animals ; Camphanes/pharmacology ; Disease Models, Animal ; Excitatory Postsynaptic Potentials/drug effects ; Luminescent Proteins/metabolism ; Male ; Models, Biological ; NG-Nitroarginine Methyl Ester/pharmacology ; Neurons/drug effects ; Paraventricular Hypothalamic Nucleus/drug effects ; Paraventricular Hypothalamic Nucleus/metabolism ; Patch-Clamp Techniques ; Picrotoxin/pharmacology ; Piperazines/pharmacology ; Piperidines/pharmacology ; Presynaptic Terminals/drug effects ; Pyrazoles/pharmacology ; Rats, Transgenic ; Rats, Wistar ; Receptors, Oxytocin/antagonists & inhibitors ; Receptors, Oxytocin/metabolism ; Red Fluorescent Protein
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Showing 1-20 from 1522 results

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