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Tytuł :
Pharmacological and metabolic characterization of the novel synthetic opioid brorphine and its detection in routine casework.
Autorzy :
Grafinger KE; Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Wilde M; Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Hermann Staudinger Graduate School, University of Freiburg, Freiburg, Germany.
Otte L; Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Auwärter V; Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: .
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Źródło :
Forensic science international [Forensic Sci Int] 2021 Oct; Vol. 327, pp. 110989. Date of Electronic Publication: 2021 Aug 31.
Typ publikacji :
Journal Article
MeSH Terms :
Analgesics, Opioid/*metabolism
Analgesics, Opioid/*pharmacology
Imidazoles/*metabolism
Imidazoles/*pharmacology
Piperidines/*metabolism
Piperidines/*pharmacology
Receptors, Opioid/*drug effects
Substance Abuse Detection/*methods
Analgesics, Opioid/blood ; Analgesics, Opioid/urine ; Chromatography, Liquid ; GTP-Binding Proteins/metabolism ; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism ; Humans ; Imidazoles/blood ; Imidazoles/urine ; Microsomes, Liver/metabolism ; Piperidines/blood ; Piperidines/urine ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
The development of novel cytochrome P450 2J2 (CYP2J2) inhibitor and the underlying interaction between inhibitor and CYP2J2.
Autorzy :
Tian X; Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Zhou M; Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Ning J; Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, Dalian Medical University, Dalian, China.
Deng X; Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Feng L; Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, Dalian Medical University, Dalian, China.
Huang H; Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Yao D; School of Pharmaceutical Sciences, Shenzhen Technology University, Shenzhen, China.
Ma X; Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 737-748.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Development*
Alkaloids/*pharmacology
Benzodioxoles/*pharmacology
Cytochrome P-450 Enzyme Inhibitors/*pharmacology
Cytochrome P-450 Enzyme System/*metabolism
Piperidines/*pharmacology
Polyunsaturated Alkamides/*pharmacology
Alkaloids/chemistry ; Alkaloids/isolation & purification ; Benzodioxoles/chemistry ; Benzodioxoles/isolation & purification ; Cytochrome P-450 Enzyme Inhibitors/chemical synthesis ; Cytochrome P-450 Enzyme Inhibitors/chemistry ; Dose-Response Relationship, Drug ; High-Throughput Screening Assays ; Humans ; Models, Molecular ; Molecular Structure ; Piperidines/chemistry ; Piperidines/isolation & purification ; Polyunsaturated Alkamides/chemistry ; Polyunsaturated Alkamides/isolation & purification ; Recombinant Proteins/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Functional evaluation of vandetanib metabolism by CYP3A4 variants and potential drug interactions in vitro.
Autorzy :
Han M; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
Zhang X; The Seventh People's Hospital of Wenzhou, Wenzhou, Zhejiang, PR China.
Ye Z; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
Wang J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
Qian J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
Hu G; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China. Electronic address: .
Cai J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Dec 01; Vol. 350, pp. 109700. Date of Electronic Publication: 2021 Oct 12.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 CYP3A/*genetics
Cytochrome P-450 CYP3A/*metabolism
Piperidines/*metabolism
Protein Kinase Inhibitors/*metabolism
Quinazolines/*metabolism
Alleles ; Biotransformation ; Cytochrome P-450 CYP3A Inhibitors/administration & dosage ; Drug Interactions ; Genetic Association Studies ; Genetic Variation ; Humans ; In Vitro Techniques ; Ketoconazole/administration & dosage ; Kinetics ; Metabolic Clearance Rate ; Piperidines/administration & dosage ; Piperidines/pharmacokinetics ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/pharmacokinetics ; Quinazolines/administration & dosage ; Quinazolines/pharmacokinetics ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Statistical optimization of bile salt deployed nanovesicles as a potential platform for oral delivery of piperine: accentuated antiviral and anti-inflammatory activity in MERS-CoV challenged mice.
Autorzy :
Zakaria MY; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
Fayad E; Department of Biotechnology, Faculty of Sciences, Taif University, Taif, Saudi Arabia.
Althobaiti F; Department of Biotechnology, Faculty of Sciences, Taif University, Taif, Saudi Arabia.
Zaki I; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
Abu Almaaty AH; Department of Zoology, Faculty of Science, Port Said University, Port Said, Egypt.
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Źródło :
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 1150-1165.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids*/administration & dosage
Alkaloids*/pharmacokinetics
Benzodioxoles*/administration & dosage
Benzodioxoles*/pharmacokinetics
Piperidines*/administration & dosage
Piperidines*/pharmacokinetics
Polyunsaturated Alkamides*/administration & dosage
Polyunsaturated Alkamides*/pharmacokinetics
Bile Acids and Salts/*pharmacokinetics
Drug Delivery Systems/*methods
Middle East Respiratory Syndrome Coronavirus/*drug effects
Administration, Oral ; Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/pharmacokinetics ; Biological Availability ; Cytochrome P-450 Enzyme Inhibitors/administration & dosage ; Cytochrome P-450 Enzyme Inhibitors/pharmacokinetics ; Drug Liberation ; Liposomes ; Mice ; Molecular Docking Simulation ; Nanostructures ; Plants, Medicinal ; Surface-Active Agents/pharmacokinetics
Czasopismo naukowe
Tytuł :
Clinical pharmacology and PK/PD translation of the second-generation Bruton's tyrosine kinase inhibitor, zanubrutinib.
Autorzy :
Tam CS; Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Department of Haematology, St Vincent's Hospital, Fitzroy, VIC, Australia.; Department of Haematology, University of Melbourne, Parkville, VIC, Australia.; Department of Haematology, Royal Melbourne Hospital, Parkville, VIC, Australia.
Ou YC; Sr. Director, Clinical Pharmacology, BeiGene USA Inc., San Mateo, CA, USA.
Trotman J; Department of Haematology, Concord Repatriation Hospital, Concord, NSW, Australia.; Department of Haematology, The University of Sydney, Concord, NSW, Australia.
Opat S; Director, Clinical Haematology, Monash Health, Clayton, VIC, Australia.; Director, Clinical Haematology, Monash University, Clayton, VIC, Australia.
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Źródło :
Expert review of clinical pharmacology [Expert Rev Clin Pharmacol] 2021 Nov; Vol. 14 (11), pp. 1329-1344. Date of Electronic Publication: 2021 Sep 20.
Typ publikacji :
Comparative Study; Journal Article; Review
MeSH Terms :
Agammaglobulinaemia Tyrosine Kinase/*antagonists & inhibitors
Piperidines/*administration & dosage
Protein Kinase Inhibitors/*administration & dosage
Pyrazoles/*administration & dosage
Pyrimidines/*administration & dosage
Adenine/administration & dosage ; Adenine/analogs & derivatives ; Adenine/pharmacokinetics ; Adenine/pharmacology ; Animals ; Drug Interactions ; Humans ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/enzymology ; Piperidines/pharmacokinetics ; Piperidines/pharmacology ; Protein Kinase Inhibitors/pharmacokinetics ; Protein Kinase Inhibitors/pharmacology ; Pyrazoles/pharmacokinetics ; Pyrazoles/pharmacology ; Pyrimidines/pharmacokinetics ; Pyrimidines/pharmacology ; Randomized Controlled Trials as Topic ; Waldenstrom Macroglobulinemia/drug therapy ; Waldenstrom Macroglobulinemia/enzymology
Czasopismo naukowe
Tytuł :
Synthesis, biological evaluation and molecular modeling of benzofuran piperidine derivatives as Aβ antiaggregant.
Autorzy :
Chowdhury SR; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Gu J; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Hu Y; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Wang J; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Lei S; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Tavallaie MS; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Lam C; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Lu D; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Jiang F; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Fu L; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China; SJTU-Agilent Technologies Joint Laboratory for Pharmaceutical Analysis, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China; Academy of Pharmacy, Xi'an Jiaotong - Liverpool University, Suzhou, 215123, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113541. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Peptides/*antagonists & inhibitors
Benzofurans/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Neuroprotective Agents/*pharmacology
Piperidines/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Benzofurans/chemical synthesis ; Benzofurans/chemistry ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Models, Molecular ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Piperidines/chemical synthesis ; Piperidines/chemistry ; Protein Aggregates/drug effects ; Protein Aggregation, Pathological/drug therapy ; Protein Aggregation, Pathological/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Discovery and evolution of 12N-substituted aloperine derivatives as anti-SARS-CoV-2 agents through targeting late entry stage.
Autorzy :
Wang K; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Wu JJ; Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Beijing 102629, China.
Xin-Zhang; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Zeng QX; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Zhang N; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Huang WJ; Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Beijing 102629, China.
Tang S; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Wang YX; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Kong WJ; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Wang YC; Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Beijing 102629, China.
Li YH; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; State Key Laboratory of Bioactive Substance & Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: .
Song DQ; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Oct; Vol. 115, pp. 105196. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Piperidines/*pharmacology
Quinolizidines/*pharmacology
SARS-CoV-2/*drug effects
Virus Internalization/*drug effects
Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/toxicity ; Cathepsin B/antagonists & inhibitors ; Chlorocebus aethiops ; Cytokines/metabolism ; HEK293 Cells ; Humans ; Male ; Mice ; Microbial Sensitivity Tests ; Molecular Structure ; Piperidines/chemical synthesis ; Piperidines/pharmacokinetics ; Piperidines/toxicity ; Quinolizidines/chemical synthesis ; Quinolizidines/pharmacokinetics ; Quinolizidines/toxicity ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Vero Cells
Czasopismo naukowe
Tytuł :
An evaluation of KBP-5074 in advanced chronic kidney disease with uncontrolled hypertension.
Autorzy :
Pitt B; Department of Medicine, University of Michigan School of Medicine, Ann Arbor, USA.
Jaisser F; Metabolism Department, Centre De Recherche Des Cordeliers. Inserm, Paris, France.
Bakris G; Department of Medicine, University of Chicago Medicine, Comprehensive Hypertension Center, Chicago, United States.
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Źródło :
Expert opinion on investigational drugs [Expert Opin Investig Drugs] 2021 Oct; Vol. 30 (10), pp. 1017-1023. Date of Electronic Publication: 2021 Oct 19.
Typ publikacji :
Journal Article
MeSH Terms :
Hypertension/*drug therapy
Piperidines/*administration & dosage
Pyrazoles/*administration & dosage
Quinolines/*administration & dosage
Renal Insufficiency, Chronic/*drug therapy
Antihypertensive Agents/administration & dosage ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/pharmacology ; Disease Progression ; Drug Resistance ; Humans ; Hypertension/etiology ; Mineralocorticoid Receptor Antagonists/administration & dosage ; Mineralocorticoid Receptor Antagonists/adverse effects ; Mineralocorticoid Receptor Antagonists/pharmacology ; Piperidines/adverse effects ; Piperidines/pharmacology ; Pyrazoles/adverse effects ; Pyrazoles/pharmacology ; Quinolines/adverse effects ; Quinolines/pharmacology ; Randomized Controlled Trials as Topic ; Renal Insufficiency, Chronic/complications
Czasopismo naukowe
Tytuł :
Evaluation of antihyperalgesic and analgesic effects of 35% nitrous oxide when combined with remifentanil: A randomised phase 1 trial in volunteers.
Autorzy :
Wehrfritz A; From the Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Anaesthesiology (AW, HI, JP, JS), Department of Orthopaedic and Trauma Surgery, Erlangen, Germany (MB), Médical R&D, Air Liquide Santé International, Les Loges-en-Josas, France (NN, JFRG, BB).
Bauer M
Noel N
Ramirez-Gil JF
Ihmsen H
Prottengeier J
Schüttler J
Bessiere B
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Źródło :
European journal of anaesthesiology [Eur J Anaesthesiol] 2021 Dec 01; Vol. 38 (12), pp. 1230-1241.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
MeSH Terms :
Nitrous Oxide*
Piperidines*/adverse effects
Analgesics, Opioid ; Double-Blind Method ; Healthy Volunteers ; Humans ; Hyperalgesia/chemically induced ; Hyperalgesia/diagnosis ; Hyperalgesia/drug therapy ; Male ; Pain, Postoperative ; Remifentanil
Czasopismo naukowe
Tytuł :
Management of ibrutinib treatment in patients with B-cell malignancies: clinical practice in Portugal and multidisciplinary recommendations.
Autorzy :
Carda JP; Serviço de Hematologia Clínica, Faculdade de Medicina da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Coimbra, Portugal.
Santos L; Centro Hospitalar Universitário de São João, Faculdade de Medicina, Universidade do Porto, Porto, Portugal.; Nephrology and Infectious Diseases R&D, I3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Mariz JM; Onco-Haematology Clinic, Instituto Português de Oncologia do Porto, EPE/IPOFG - CRO, Porto, Portugal.
Monteiro P; Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Gonçalves HM; Serviço Farmacêutico, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal.
Raposo J; Centro Hospitalar Universitário Lisboa Norte, EPE, Lisboa, Portugal.
Gomes da Silva M; Instituto Português de Oncologia de Lisboa, Francisco Gentil, EPE, Lisbon, Portugal.
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Źródło :
Hematology (Amsterdam, Netherlands) [Hematology] 2021 Dec; Vol. 26 (1), pp. 785-798.
Typ publikacji :
Journal Article
MeSH Terms :
Adenine/*analogs & derivatives
Leukemia, B-Cell/*drug therapy
Piperidines/*therapeutic use
Protein Kinase Inhibitors/*therapeutic use
Adenine/adverse effects ; Adenine/therapeutic use ; Agammaglobulinaemia Tyrosine Kinase/antagonists & inhibitors ; Disease Management ; Humans ; Leukemia, B-Cell/epidemiology ; Patient Care ; Piperidines/adverse effects ; Portugal/epidemiology ; Protein Kinase Inhibitors/adverse effects
Czasopismo naukowe
Tytuł :
Application of a Validated UPLC-MS-MS Method for the Determination of Diphenidol in Biological Samples in 15 Authentic Lethal Cases.
Autorzy :
Yang L; College of Medicine & Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China.; Department of Forensic Toxicology, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Academy of Forensic Science, Shanghai 200063, China.
Shen M; Department of Forensic Toxicology, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Academy of Forensic Science, Shanghai 200063, China.
Xiang P; Department of Forensic Toxicology, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Academy of Forensic Science, Shanghai 200063, China.
Shen B; Department of Forensic Toxicology, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Academy of Forensic Science, Shanghai 200063, China.
Deng H; Department of Forensic Toxicology, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Academy of Forensic Science, Shanghai 200063, China.
Qiang H; Department of Forensic Toxicology, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Academy of Forensic Science, Shanghai 200063, China.
Dang Y; College of Medicine & Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China.
Shi Y; Department of Forensic Toxicology, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Academy of Forensic Science, Shanghai 200063, China.
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Źródło :
Journal of analytical toxicology [J Anal Toxicol] 2021 Nov 09; Vol. 45 (9), pp. 976-984.
Typ publikacji :
Journal Article
MeSH Terms :
Piperidines*
Tandem Mass Spectrometry*
Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Humans
Czasopismo naukowe
Tytuł :
Cyclisations and Strategies for Stereoselective Synthesis of Piperidine Iminosugars.
Autorzy :
Dhara D; School of Biological and Chemical Sciences, NUI Galway, University Road, Galway, H91 TK33, Ireland.; Unité de Chimie des Biomolécules, UMR 3523 CNRS, Institut Pasteur, Université de Paris, 28 rue du Dr Roux, 75015, Paris, France.
Dhara A; School of Biological and Chemical Sciences, NUI Galway, University Road, Galway, H91 TK33, Ireland.
Bennett J; School of Biological and Chemical Sciences, NUI Galway, University Road, Galway, H91 TK33, Ireland.
Murphy PV; School of Biological and Chemical Sciences, NUI Galway, University Road, Galway, H91 TK33, Ireland.; SSPC - The Science Foundation Ireland Research Centre for Pharmaceuticals, NUI Galway, University Road, Galway, H91 TK33, Ireland.
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Źródło :
Chemical record (New York, N.Y.) [Chem Rec] 2021 Nov; Vol. 21 (11), pp. 2958-2979. Date of Electronic Publication: 2021 Oct 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Azides*
Piperidines*
Alkenes ; Cycloaddition Reaction
Czasopismo naukowe
Tytuł :
Concurrent ibrutinib plus venetoclax in relapsed/refractory mantle cell lymphoma: the safety run-in of the phase 3 SYMPATICO study.
Autorzy :
Wang M; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd #368, Houston, TX, 77030, USA. .
Ramchandren R; University of Tennessee, Knoxville, TN, USA.
Chen R; City of Hope National Medical Center, Duarte, CA, USA.
Karlin L; Centre Hospitalier Lyon Sud, Lyon, France.
Chong G; Olivia Newton-John Cancer Centre, Heidelberg, VIC, Australia.
Jurczak W; Sklodowska Curie National Research Institute of Oncology, Kraków, Poland.
Wu KL; Ziekenhuis Netwerk Antwerpen, Antwerp, Belgium.
Bishton M; Nottinghamshire University Hospitals, Nottingham, UK.
Collins GP; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK.
Eliadis P; Icon Cancer Centre, South Brisbane, QLD, Australia.
Peyrade F; Centre Antoine Lacassagne, Nice Cedex 2, France.
Lee Y; Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA.
Eckert K; Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA.
Neuenburg JK; Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA.
Tam CS; Peter MacCallum Cancer Centre, Royal Melbourne Hospital, St Vincent's Hospital, University of Melbourne, Melbourne, VIC, Australia.
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Źródło :
Journal of hematology & oncology [J Hematol Oncol] 2021 Oct 30; Vol. 14 (1), pp. 179. Date of Electronic Publication: 2021 Oct 30.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenine/*analogs & derivatives
Antineoplastic Agents/*therapeutic use
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Bridged Bicyclo Compounds, Heterocyclic/*therapeutic use
Lymphoma, Mantle-Cell/*drug therapy
Neoplasm Recurrence, Local/*drug therapy
Piperidines/*therapeutic use
Sulfonamides/*therapeutic use
Adenine/adverse effects ; Adenine/therapeutic use ; Aged ; Antineoplastic Agents/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bridged Bicyclo Compounds, Heterocyclic/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Piperidines/adverse effects ; Sulfonamides/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Enteral administration of alectinib for ALK-positive non-small cell lung cancer in an elderly patient: A case report.
Autorzy :
Thomas QD; Medical Oncology Department, Institut du Cancer de Montpellier (ICM), Montpellier University, Montpellier, France.
Pautas M; Medical Oncology Department, Institut Curie, Paris, France.; Paris Saclay University, Saint Aubin, France.
Guilhaume MN; Medical Oncology Department, Institut Curie, Paris, France.; Paris Saclay University, Saint Aubin, France.
Fiteni F; Medical Oncology Department, Centre Hospitalier Universitaire de Nîmes, Nîmes, France.
Ge T; Medical Oncology Department, Institut Curie, Paris, France.; Paris Saclay University, Saint Aubin, France.
Girard N; Medical Oncology Department, Institut Curie, Paris, France.; Paris Saclay University, Saint Aubin, France.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Oct 29; Vol. 100 (43), pp. e27611.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Carbazoles/*therapeutic use
Carcinoma, Non-Small-Cell Lung/*drug therapy
Lung Neoplasms/*drug therapy
Piperidines/*therapeutic use
Protein Kinase Inhibitors/*therapeutic use
Aged, 80 and over ; Anaplastic Lymphoma Kinase/biosynthesis ; Carbazoles/administration & dosage ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Drug Administration Routes ; Gastrostomy ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Piperidines/administration & dosage ; Protein Kinase Inhibitors/administration & dosage
Czasopismo naukowe
Tytuł :
Pimavanserin and dementia-related psychosis: can HARMONY prevail?
Autorzy :
Liu KY; Division of Psychiatry, University College London, London W1T 7NF, UK.
Howard R; Division of Psychiatry, University College London, London W1T 7NF, UK. Electronic address: .
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Źródło :
The Lancet. Neurology [Lancet Neurol] 2021 Oct; Vol. 20 (10), pp. 783-784. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dementia/*drug therapy
Piperidines/*therapeutic use
Psychotic Disorders/*drug therapy
Urea/*analogs & derivatives
Clinical Trials as Topic/methods ; Humans ; Piperidines/adverse effects ; Urea/adverse effects ; Urea/therapeutic use
Czasopismo naukowe
Tytuł :
A rohitukine derivative IIIM-290 induces p53 dependent mitochondrial apoptosis in acute lymphoblastic leukemia cells.
Autorzy :
Mintoo M; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Khan S; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Wani A; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Malik S; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Bhurta D; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Bharate S; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Malik F; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Mondhe D; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2021 Oct; Vol. 60 (10), pp. 671-683. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Chromones/*pharmacology
Mitochondria/*drug effects
Mitochondria/*metabolism
Piperidines/*pharmacology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*metabolism
Animals ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Cell Line, Tumor ; Chromones/chemistry ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Piperidines/chemistry ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Tumor Suppressor Protein p53/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Death associated with brorphine, an emerging novel synthetic opioid.
Autorzy :
Vohra V; Michigan Poison Center, Wayne State University School of Medicine, Detroit, Michigan, USA.
King AM; Michigan Poison Center, Wayne State University School of Medicine, Detroit, Michigan, USA.; Detroit Medical Center, Department of Emergency Medicine, Detroit, Michigan, USA.
Jacobs E; Detroit Medical Center, Department of Emergency Medicine, Detroit, Michigan, USA.
Aaron C; Michigan Poison Center, Wayne State University School of Medicine, Detroit, Michigan, USA.
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Źródło :
Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2021 Sep; Vol. 59 (9), pp. 851-852. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Analgesics, Opioid/*toxicity
Drug Overdose/*mortality
Fentanyl/*toxicity
Imidazoles/*toxicity
Opioid-Related Disorders/*mortality
Piperidines/*toxicity
Synthetic Drugs/*toxicity
Cause of Death ; Fatal Outcome ; Female ; Fentanyl/blood ; Fentanyl/urine ; Humans ; Imidazoles/blood ; Imidazoles/urine ; Michigan ; Middle Aged ; Opioid-Related Disorders/epidemiology ; Piperidines/blood ; Piperidines/urine ; Population Surveillance
Raport
Tytuł :
Keeping a balance in chronic lymphocytic leukemia (CLL) patients taking ibrutinib: ibrutinib-associated adverse events and their management based on drug interactions.
Autorzy :
Cho HJ; Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea.
Baek DW; Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea.
Kim J; Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea.
Lee JM; Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea.
Moon JH; Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea.
Sohn SK; Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea.
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Źródło :
Expert review of hematology [Expert Rev Hematol] 2021 Sep; Vol. 14 (9), pp. 819-830. Date of Electronic Publication: 2021 Aug 22.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Adenine/*analogs & derivatives
Leukemia, Lymphocytic, Chronic, B-Cell/*drug therapy
Piperidines/*therapeutic use
Protein Kinase Inhibitors/*therapeutic use
Adenine/adverse effects ; Adenine/pharmacology ; Adenine/therapeutic use ; Aged ; COVID-19/complications ; Disease Management ; Drug Interactions ; Drug-Related Side Effects and Adverse Reactions/etiology ; Drug-Related Side Effects and Adverse Reactions/therapy ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Male ; Piperidines/adverse effects ; Piperidines/pharmacology ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H).
Autorzy :
Koike T; Research, Takeda Pharmaceutical Company Ltd., 26-1 Muraoka-Higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Yoshikawa M; Research, Takeda Pharmaceutical Company Ltd., 26-1 Muraoka-Higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Ando HK; Research, Takeda Pharmaceutical Company Ltd., 26-1 Muraoka-Higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Farnaby W; Research, Takeda Pharmaceutical Company Ltd., 26-1 Muraoka-Higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Nishi T; Research, Takeda Pharmaceutical Company Ltd., 26-1 Muraoka-Higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Watanabe E; Research, Takeda Pharmaceutical Company Ltd., 26-1 Muraoka-Higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Yano J; Takeda California Inc., 9625 Towne Centre Drive, San Diego, California 92121, United States.
Miyamoto M; Research, Takeda Pharmaceutical Company Ltd., 26-1 Muraoka-Higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Kondo S; Research, Takeda Pharmaceutical Company Ltd., 26-1 Muraoka-Higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Ishii T; Research, Takeda Pharmaceutical Company Ltd., 26-1 Muraoka-Higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Kuroita T; Research, Takeda Pharmaceutical Company Ltd., 26-1 Muraoka-Higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Aug 26; Vol. 64 (16), pp. 12228-12244. Date of Electronic Publication: 2021 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cholesterol 24-Hydroxylase/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Piperidines/*pharmacology
Pyridines/*pharmacology
Animals ; Brain/drug effects ; Brain/enzymology ; Cholesterol 24-Hydroxylase/metabolism ; Crystallography, X-Ray ; Drug Stability ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/metabolism ; Female ; Humans ; Mice, Inbred C57BL ; Microsomes, Liver/metabolism ; Molecular Structure ; Piperidines/chemical synthesis ; Piperidines/metabolism ; Protein Binding ; Pyridines/chemical synthesis ; Pyridines/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.
Autorzy :
Wang Z; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9497, United States.
Zhang M; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9497, United States.
Quereda V; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9497, United States.
Frydman SM; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9497, United States.
Ming Q; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9497, United States.
Luca VC; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9497, United States.
Duckett DR; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9497, United States.
Ji H; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9497, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Aug 26; Vol. 64 (16), pp. 12109-12131. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Neoplasms/*drug therapy
Piperidines/*therapeutic use
Protein Binding/*drug effects
Transcription Factors/*antagonists & inhibitors
beta Catenin/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacokinetics ; Cell Line, Tumor ; Cell Movement/drug effects ; Drug Design ; Female ; Humans ; Male ; Mice, Inbred C57BL ; Mice, SCID ; Molecular Structure ; Piperidines/chemical synthesis ; Piperidines/pharmacokinetics ; Structure-Activity Relationship ; Transcription Factors/metabolism ; Xenograft Model Antitumor Assays ; beta Catenin/metabolism
Czasopismo naukowe

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