Autor: "Piro RM" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Genome-wide insights into population structure and host specificity of Campylobacter jejuni.
Autorzy:: Epping L; Genome Sequencing and Genomic Epidemiology, Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany.
Walther B; Advanced Light and Electron Microscopy, Robert Koch Institute, Berlin, Germany.
Piro RM; Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy.; Department of Mathematics and Computer Science, Freie Universität, Berlin, Germany.
Knüver MT; National Reference Laboratory for Campylobacter, Department of Biological Safety, German Federal Institute for Risk Assessment, Berlin, Germany.
Huber C; Advanced Light and Electron Microscopy, Robert Koch Institute, Berlin, Germany.
Thürmer A; Genome Sequencing and Genomic Epidemiology, Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany.
Flieger A; Division of Enteropathogenic Bacteria and Legionella, Department of Infectious Diseases, National Reference Centre for Salmonella and Other Bacterial Enterics, Robert Koch Institute, Wernigerode, Germany.
Fruth A; Division of Enteropathogenic Bacteria and Legionella, Department of Infectious Diseases, National Reference Centre for Salmonella and Other Bacterial Enterics, Robert Koch Institute, Wernigerode, Germany.
Janecko N; Microbes in the Food Chain, Quadram Institute Bioscience, Norwich, UK.
Wieler LH; Methodology and Research Infrastructure, Robert Koch Institute, Berlin, Germany.
Stingl K; National Reference Laboratory for Campylobacter, Department of Biological Safety, German Federal Institute for Risk Assessment, Berlin, Germany.
Semmler T; Genome Sequencing and Genomic Epidemiology, Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 May 14; Vol. 11 (1), pp. 10358. Date of Electronic Publication: 2021 May 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Campylobacter Infections/*microbiology
Campylobacter jejuni/*genetics
Foodborne Diseases/*microbiology
Host Specificity/*genetics
Host-Pathogen Interactions/*genetics
Alleles ; Animals ; Campylobacter jejuni/metabolism ; Campylobacter jejuni/pathogenicity ; Canada ; DNA, Bacterial/genetics ; DNA, Bacterial/isolation & purification ; DNA, Environmental/genetics ; Genes, Bacterial ; Germany ; Humans ; Metabolic Networks and Pathways/genetics ; Phylogeny ; Whole Genome Sequencing

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Skocz do pozycji: 2.

Tytuł:: PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma.
Autorzy:: Soni H; Brain Tumor Translational Targets, DKFZ Junior Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Mechanisms of Tumor Invasion, Schaller Research Group, University of Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Bode J; Molecular Mechanisms of Tumor Invasion, Schaller Research Group, University of Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nguyen CDL; Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V, Dortmund, Germany.
Puccio L; Brain Tumor Translational Targets, DKFZ Junior Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Neßling M; Central Unit Electron Microscopy, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Piro RM; Institute of Computer Science, Institute of Bioinformatics, Freie Universität Berlin, Berlin, Germany.; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK) partner site Berlin, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Bub J; Brain Tumor Translational Targets, DKFZ Junior Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Phillips E; Brain Tumor Translational Targets, DKFZ Junior Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ahrends R; Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V, Dortmund, Germany.; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Wien, Austria.
Eipper BA; UConn Health, Farmington, CT, USA.
Tews B; Molecular Mechanisms of Tumor Invasion, Schaller Research Group, University of Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Goidts V; Brain Tumor Translational Targets, DKFZ Junior Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. .; Pokaż więcej
Źródło:: Oncogenesis [Oncogenesis] 2020 Feb 13; Vol. 9 (2), pp. 18. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji:: Journal Article

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Skocz do pozycji: 3.

Tytuł:: decompTumor2Sig: identification of mutational signatures active in individual tumors.
Autorzy:: Krüger S; Institute of Computer Science and Institute of Bioinformatics, Freie Universität Berlin, Berlin, Germany.
Piro RM; Institute of Computer Science and Institute of Bioinformatics, Freie Universität Berlin, Berlin, Germany. r.piro@fu-berlin.de.; Institute of Medical Genetics and Human Genetics, Charité - Universitätsmedizin Berlin, Berlin, Germany. r.piro@fu-berlin.de.; German Cancer Consortium (DKTK) partner site Berlin, and German Cancer Research Center (DKFZ), Heidelberg, Germany. r.piro@fu-berlin.de.; Pokaż więcej
Źródło:: BMC bioinformatics [BMC Bioinformatics] 2019 Apr 18; Vol. 20 (Suppl 4), pp. 152. Date of Electronic Publication: 2019 Apr 18.
Typ publikacji:: Journal Article
MeSH Terms:: Software*
Mutation/*genetics
Neoplasms/*genetics
Base Sequence ; Computer Simulation ; Genome, Human ; Humans ; Models, Genetic ; Models, Statistical ; Mutation Rate

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Skocz do pozycji: 4.

Tytuł:: Stem cell characteristics in glioblastoma are maintained by the ecto-nucleotidase E-NPP1.
Autorzy:: Bageritz J; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Puccio L; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Piro RM; 1] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany [2] Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany.
Hovestadt V; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Phillips E; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Pankert T; Research Group Genome Organization & Function, German Cancer Research Center (DKFZ) & BioQuant, Heidelberg, Germany.
Lohr J; Division of Experimental Neurosurgery, University of Heidelberg, Heidelberg, Germany.
Herold-Mende C; Division of Experimental Neurosurgery, University of Heidelberg, Heidelberg, Germany.
Lichter P; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Goidts V; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Pokaż więcej
Źródło:: Cell death and differentiation [Cell Death Differ] 2014 Jun; Vol. 21 (6), pp. 929-40. Date of Electronic Publication: 2014 Feb 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain Neoplasms/*genetics
Glioblastoma/*genetics
Neural Stem Cells/*metabolism
Phosphoric Diester Hydrolases/*metabolism
Pyrophosphatases/*metabolism
AC133 Antigen ; Antigens, CD/biosynthesis ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Cycle Checkpoints/genetics ; Cell Differentiation/genetics ; Cell Line, Tumor ; Cell Lineage ; E2F1 Transcription Factor/metabolism ; Gene Expression Regulation, Neoplastic ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Glycoproteins/biosynthesis ; Humans ; Peptides ; Phosphoric Diester Hydrolases/genetics ; Pyrophosphatases/genetics

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Skocz do pozycji: 5.

Tytuł:: Network topology-based detection of differential gene regulation and regulatory switches in cell metabolism and signaling.
Autorzy:: Piro RM
Wiesberg S
Schramm G
Rebel N
Oswald M
Eils R
Reinelt G
König R; Division of Theoretical Bioinformatics, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg, Germany. .; Pokaż więcej
Źródło:: BMC systems biology [BMC Syst Biol] 2014 May 16; Vol. 8, pp. 56. Date of Electronic Publication: 2014 May 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation*
Gene Regulatory Networks*
Software*
Computational Biology/*methods
Metabolic Networks and Pathways/*genetics
Signal Transduction/*genetics
Aging/genetics ; Animals ; Drosophila melanogaster/genetics ; Drosophila melanogaster/physiology ; Longevity/genetics ; Lung Neoplasms/metabolism ; User-Computer Interface

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Tytuł:: Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.
Autorzy:: Mack SC; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada [4].
Witt H; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [3] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [4].
Piro RM; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Gu L; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Zuyderduyn S; Department of Molecular Genetics, Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Ontario M4N 1X8, Canada.
Stütz AM; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Genome Biology, European Molecular Biology, Laboratory Meyerhofstr. 1, Heidelberg 69117, Germany.
Wang X; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Gallo M; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Garzia L; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Zayne K; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Zhang X; Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.
Ramaswamy V; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Jäger N; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Jones DT; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
Sill M; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Pugh TJ; Department of Neurology, Harvard Medical School, Children's Hospital Boston, MIT, Boston, Massachusetts 02115, USA.
Ryzhova M; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
Wani KM; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Shih DJ; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Head R; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Remke M; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Bailey SD; 1] Ontario Cancer Institute, Princess Margaret Cancer Centre-University Health Network, Toronto, Ontario M5G 1L7, Canada [2] Ontario Institute for Cancer Research, Toronto, Ontario M5G 1L7, Canada.
Zichner T; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Genome Biology, European Molecular Biology, Laboratory Meyerhofstr. 1, Heidelberg 69117, Germany.
Faria CC; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Barszczyk M; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Stark S; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
Seker-Cin H; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
Hutter S; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
Johann P; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
Bender S; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
Hovestadt V; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Tzaridis T; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
Dubuc AM; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Northcott PA; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
Peacock J; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Bertrand KC; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Agnihotri S; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Cavalli FM; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Clarke I; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Nethery-Brokx K; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Creasy CL; Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania 19426, USA.
Verma SK; Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania 19426, USA.
Koster J; Department of Oncogenomics, Academic Medical Center, Amsterdam 1105, The Netherlands.
Wu X; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Yao Y; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Milde T; 1] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [3] CCU Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Sin-Chan P; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Zuccaro J; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Lau L; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Pereira S; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Castelo-Branco P; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Hirst M; 1] Centre for High-Throughput Biology, Department of Microbiology & Immunology, University of British Columbia, Vancouver, V6T 1Z4 British Columbia, Canada [2] Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.
Marra MA; 1] Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada [2] Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada.
Roberts SS; Department of Pediatrics and National Capital Consortium, Uniformed Services University, Bethesda, Maryland 20814, USA.
Fults D; Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.
Massimi L; Pediatric Neurosurgery, Catholic University Medical School, Gemelli Hospital, Rome 00168, Italy.
Cho YJ; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.
Van Meter T; Department of Pediatrics, Virginia Commonwealth, Richmond, Virginia 23298-0646, USA.
Grajkowska W; Department of Pathology, University of Warsaw, Children's Memorial Health Institute University of Warsaw, Warsaw 04-730, Poland.
Lach B; Division of Anatomical Pathology, Department of Pathology and Molecular Medicine, McMaster University, Hamilton General Hospital, Hamilton, Ontario L8S 4K1, Canada.
Kulozik AE; 1] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
von Deimling A; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Department of Neuropathology Ruprecht-Karls-University Heidelberg, Institute of Pathology, Heidelberg 69120, Germany.
Witt O; 1] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [3] CCU Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Scherer SW; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Fan X; 1] University of Michigan Cell and Developmental Biology, Ann Arbor, Michigan 48109-2200, USA [2] Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Muraszko KM; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Kool M; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
Pomeroy SL; Department of Neurology, Harvard Medical School, Children's Hospital Boston, MIT, Boston, Massachusetts 02115, USA.
Gupta N; Department of Neurosurgery, University of California San Francisco, San Francisco, California 94143-0112, USA.
Phillips J; Departments of Neurology, Pediatrics, and Neurosurgery, University of California, San Francisco, The Helen Diller Family Cancer Research Building, San Francisco, California 94158, USA.
Huang A; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Department of Neuro-oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
Tabori U; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Department of Neuro-oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
Hawkins C; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Malkin D; Department of Haematology and Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
Kongkham PN; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Weiss WA; Departments of Neurology, Pediatrics, and Neurosurgery, University of California, San Francisco, The Helen Diller Family Cancer Research Building, San Francisco, California 94158, USA.
Jabado N; Departments of Pediatrics and Human Genetics, McGill University and the McGill University Health Center Research Institute, Montreal, Quebec H3Z 2Z3, Canada.
Rutka JT; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Bouffet E; Department of Neuro-oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
Korbel JO; Genome Biology, European Molecular Biology, Laboratory Meyerhofstr. 1, Heidelberg 69117, Germany.
Lupien M; 1] Ontario Cancer Institute, Princess Margaret Cancer Centre-University Health Network, Toronto, Ontario M5G 1L7, Canada [2] Ontario Institute for Cancer Research, Toronto, Ontario M5G 1L7, Canada [3] Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1X8, Canada.
Aldape KD; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Bader GD; Department of Molecular Genetics, Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Ontario M4N 1X8, Canada.
Eils R; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Lichter P; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Dirks PB; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada [4] Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Pfister SM; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [3] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
Korshunov A; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] University of Michigan Cell and Developmental Biology, Ann Arbor, Michigan 48109-2200, USA [3] CCU Neuropathology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Taylor MD; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Pokaż więcej
Źródło:: Nature [Nature] 2014 Feb 27; Vol. 506 (7489), pp. 445-50. Date of Electronic Publication: 2014 Feb 19.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: CpG Islands/*genetics
Ependymoma/*genetics
Epigenesis, Genetic/*genetics
Animals ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; DNA Methylation/drug effects ; Embryonic Stem Cells/metabolism ; Ependymoma/drug therapy ; Epigenomics ; Female ; Gene Expression Regulation, Neoplastic ; Gene Silencing/drug effects ; Histones/drug effects ; Histones/metabolism ; Humans ; Infant ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mutation/genetics ; Phenotype ; Polycomb Repressive Complex 2/metabolism ; Prognosis ; Rhombencephalon/pathology ; Xenograft Model Antitumor Assays

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Skocz do pozycji: 7.

Tytuł:: BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.
Autorzy:: Tönjes M; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Barbus S; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Park YJ; Division of Epigenomics and Cancer Risk Factors, DKFZ, Heidelberg, Germany.; Department of Nutritional Science and Food Management, College of Health Science, Ewha Womans University, Seoul, South Korea.
Wang W; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Schlotter M; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lindroth AM; Division of Epigenomics and Cancer Risk Factors, DKFZ, Heidelberg, Germany.
Pleier SV; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.
Bai AHC; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Karra D; Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.
Piro RM; Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany.; Division of Theoretical Bioinformatics, DKFZ, Heidelberg, Germany.
Felsberg J; Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.
Addington A; Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute, Blacksburg, Virginia, USA.
Lemke D; Clinical Cooperation Unit Neurooncology, DKFZ, Heidelberg, Germany.
Weibrecht I; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hovestadt V; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Rolli CG; Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Stuttgart, Germany.
Campos B; Division of Experimental Neurosurgery, University of Heidelberg, Heidelberg, Germany.; Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany.
Turcan S; Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Sturm D; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
Witt H; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
Chan TA; Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Herold-Mende C; Division of Experimental Neurosurgery, University of Heidelberg, Heidelberg, Germany.; Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany.
Kemkemer R; Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Stuttgart, Germany.; Reutlingen University of Applied Science, Reutlingen, Germany.
König R; Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany.; Division of Theoretical Bioinformatics, DKFZ, Heidelberg, Germany.
Schmidt K; Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children's Hospital, Heidelberg, Germany.
Hull WE; Core Facility, Molecular Structural Analysis, DKFZ, Heidelberg, Germany.
Pfister SM; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
Jugold M; Core Facility, Small Animal Imaging Center, DKFZ, Heidelberg, Germany.
Hutson SM; Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute, Blacksburg, Virginia, USA.
Plass C; Division of Epigenomics and Cancer Risk Factors, DKFZ, Heidelberg, Germany.
Okun JG; Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children's Hospital, Heidelberg, Germany.
Reifenberger G; Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.; German Cancer Consortium (DKTK), DKFZ, Heidelberg, Germany.
Lichter P; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Radlwimmer B; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Pokaż więcej
Źródło:: Nature medicine [Nat Med] 2013 Jul; Vol. 19 (7), pp. 901-908. Date of Electronic Publication: 2013 Jun 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Proliferation*
Amino Acids, Branched-Chain/*metabolism
Brain Neoplasms/*metabolism
Glioma/*metabolism
Transaminases/*physiology
Animals ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Female ; Glioma/genetics ; Glioma/pathology ; HEK293 Cells ; Humans ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/physiology ; Metabolism/genetics ; Mice ; Mice, Nude ; Models, Biological ; Transaminases/genetics ; Transaminases/metabolism

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Skocz do pozycji: 8.

Tytuł:: Computational approaches to disease-gene prediction: rationale, classification and successes.
Autorzy:: Piro RM; Department of Theoretical Bioinformatics, German Cancer Research Center, (DKFZ), Heidelberg, Germany. r.piro@dkfz.de
Di Cunto F; Pokaż więcej
Źródło:: The FEBS journal [FEBS J] 2012 Mar; Vol. 279 (5), pp. 678-96. Date of Electronic Publication: 2012 Jan 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Computational Biology*
Genetic Linkage*
Genetic Predisposition to Disease*
Genome, Human*
Genes/*genetics
Genome-Wide Association Study ; Humans

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na półce

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Skocz do pozycji: 9.

Tytuł:: An atlas of tissue-specific conserved coexpression for functional annotation and disease gene prediction.
Autorzy:: Piro RM; Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Turin, Turin, Italy.
Ala U
Molineris I
Grassi E
Bracco C
Perego GP
Provero P
Di Cunto F; Pokaż więcej
Źródło:: European journal of human genetics : EJHG [Eur J Hum Genet] 2011 Nov; Vol. 19 (11), pp. 1173-80. Date of Electronic Publication: 2011 Jun 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Profiling*
Gene Expression Regulation*
Gene Regulatory Networks*
Disease/*genetics
Animals ; Chromosomes, Human, X ; Exome ; Genome-Wide Association Study ; High-Throughput Nucleotide Sequencing ; Humans ; Mental Retardation, X-Linked/genetics ; Mice ; Organ Specificity/genetics ; Phenotype

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Skocz do pozycji: 10.

Tytuł:: Evaluation of candidate genes from orphan FEB and GEFS+ loci by analysis of human brain gene expression atlases.
Autorzy:: Piro RM; Molecular Biotechnology Center and Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy. r.piro@dkfz.de
Molineris I
Ala U
Di Cunto F; Pokaż więcej
Źródło:: PloS one [PLoS One] 2011; Vol. 6 (8), pp. e23149. Date of Electronic Publication: 2011 Aug 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain/*metabolism
Epilepsy, Generalized/*genetics
Gene Expression Profiling/*methods
Genetic Predisposition to Disease/*genetics
Seizures, Febrile/*genetics
Brain/pathology ; Epilepsy, Generalized/diagnosis ; Humans ; Mutation ; Oligonucleotide Array Sequence Analysis ; Reproducibility of Results ; Seizures, Febrile/diagnosis ; Sensitivity and Specificity

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Skocz do pozycji: 11.

Tytuł:: Functional annotation and identification of candidate disease genes by computational analysis of normal tissue gene expression data.
Autorzy:: Miozzi L; Institute of Plant Virology, CNR, Turin, Italy.
Piro RM
Rosa F
Ala U
Silengo L
Di Cunto F
Provero P; Pokaż więcej
Źródło:: PloS one [PLoS One] 2008 Jun 18; Vol. 3 (6), pp. e2439. Date of Electronic Publication: 2008 Jun 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Computational Biology*
Gene Expression*
Genetic Predisposition to Disease ; Humans ; Oligonucleotide Array Sequence Analysis

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na półce

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Skocz do pozycji: 12.

Tytuł:: Prediction of human disease genes by human-mouse conserved coexpression analysis.
Autorzy:: Ala U; Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy.
Piro RM
Grassi E
Damasco C
Silengo L
Oti M
Provero P
Di Cunto F; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2008 Mar 28; Vol. 4 (3), pp. e1000043. Date of Electronic Publication: 2008 Mar 28.
Typ publikacji:: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Chromosome Mapping/*methods
Diagnosis, Computer-Assisted/*methods
Gene Expression Profiling/*methods
Genetic Diseases, Inborn/*diagnosis
Genetic Diseases, Inborn/*genetics
Genetic Predisposition to Disease/*genetics
Proteome/*genetics
Algorithms ; Animals ; Biomarkers/analysis ; Conserved Sequence/genetics ; Humans ; Mice ; Proteome/analysis

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