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Wyszukujesz frazę ""Plasmodium berghei"" wg kryterium: Temat


Tytuł :
Antiplasmodial activity of Ethanolic extract of Cassia spectabilis DC leaf and its inhibition effect in Heme detoxification.
Autorzy :
Ekasari W; Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Campus C, Mulyorejo Street, Surabaya, 60115, Indonesia. .
Basuki DR; Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Campus C, Mulyorejo Street, Surabaya, 60115, Indonesia.
Arwati H; Department of Medical Parasitology, Faculty of Medicine, Universitas Airlangga, Campus A, Surabaya, 60132, Indonesia.
Wahyuni TS; Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Campus C, Mulyorejo Street, Surabaya, 60115, Indonesia.
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Źródło :
BMC complementary medicine and therapies [BMC Complement Med Ther] 2021 Feb 19; Vol. 21 (1), pp. 71. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antimalarials/*pharmacology
Cassia/*chemistry
Heme/*metabolism
Malaria/*parasitology
Plant Extracts/*pharmacology
Plasmodium berghei/*drug effects
Plasmodium falciparum/*drug effects
Animals ; Antimalarials/isolation & purification ; Antimalarials/therapeutic use ; Artesunate/therapeutic use ; Chloroquine/analogs & derivatives ; Chloroquine/pharmacology ; Ketones ; Malaria/drug therapy ; Male ; Mice, Inbred BALB C ; Phytotherapy ; Piperidines ; Plant Extracts/chemistry ; Plant Extracts/therapeutic use ; Plant Leaves/chemistry ; Plasmodium berghei/metabolism ; Plasmodium falciparum/metabolism
Czasopismo naukowe
Tytuł :
Comparative antimalarial, toxicity and mito-protective effects of Diospyros mespiliformis Hochst. ex A. DC. and Mondia whitei (Hook.f.) Skeels on Plasmodium berghei infection in mice.
Autorzy :
Olanlokun JO; Laboratories for Biomembrane Research and Biotechnology, Department of Biochemistry, University of Ibadan, Nigeria. Electronic address: .
Bodede O; Department of Agriculture and Animal Health, University of South Africa, Florida Campus, Florida, 1710, South Africa.
Prinsloo G; Department of Agriculture and Animal Health, University of South Africa, Florida Campus, Florida, 1710, South Africa.
Olorunsogo OO; Laboratories for Biomembrane Research and Biotechnology, Department of Biochemistry, University of Ibadan, Nigeria.
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 25; Vol. 268, pp. 113585. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Apocynaceae*
Diospyros*
Antimalarials/*therapeutic use
Malaria/*drug therapy
Mitochondria/*drug effects
Plant Extracts/*therapeutic use
Plasmodium berghei/*drug effects
Animals ; Antimalarials/isolation & purification ; Antimalarials/pharmacology ; Dose-Response Relationship, Drug ; Malaria/metabolism ; Male ; Mice ; Mitochondria/metabolism ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plasmodium berghei/physiology ; Random Allocation
Czasopismo naukowe
Tytuł :
Intervention of standardized ethanol leaf extract of Annickia polycarpa, (DC.) Setten and Maas ex I.M. Turner. (Annonaceae), in Plasmodium berghei infested mice produced anti-malaria action and normalized gross hematological indices.
Autorzy :
Kumatia EK; Phytochemistry Department, Centre for Plant Medicine Research, Mampong-Akwapim, Ghana. Electronic address: .
Ayertey F; Phytochemistry Department, Centre for Plant Medicine Research, Mampong-Akwapim, Ghana.
Appiah-Opong R; Chemical Pathology Department, Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana.
Bagyour GK; Chemistry and Applied Biochemistry Department, University of Development Studies, Navrongo-Campus, Tamale, Ghana.
Asare KO; Clinical Resaerch Department, Centre for Plant Medicine Research, Mampong-Akwapim, Ghana.
Mbatcho VC; Chemistry and Applied Biochemistry Department, University of Development Studies, Navrongo-Campus, Tamale, Ghana.
Dabo J; Biodiversity Conservation and Ecoservices Division, Forestry Research Institute of Ghana, Kumasi, Ghana.
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 113449. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Journal Article
MeSH Terms :
Annonaceae*/chemistry
Plant Leaves*/chemistry
Antimalarials/*pharmacology
Malaria/*drug therapy
Plant Extracts/*pharmacology
Plasmodium berghei/*drug effects
Anemia/blood ; Anemia/drug therapy ; Anemia/parasitology ; Animals ; Antimalarials/isolation & purification ; Aporphines/pharmacology ; Disease Models, Animal ; Ethanol/chemistry ; Female ; Leukopenia/blood ; Leukopenia/drug therapy ; Leukopenia/parasitology ; Malaria/blood ; Malaria/parasitology ; Mice, Inbred ICR ; Parasite Load ; Parasitemia/blood ; Parasitemia/drug therapy ; Parasitemia/parasitology ; Plant Extracts/isolation & purification ; Plasmodium berghei/growth & development ; Polycythemia/blood ; Polycythemia/drug therapy ; Polycythemia/parasitology ; Solvents/chemistry ; Thrombocytopenia/blood ; Thrombocytopenia/drug therapy ; Thrombocytopenia/parasitology
Czasopismo naukowe
Tytuł :
Virus-like particles expressing Plasmodium berghei MSP-8 induce protection against P. berghei infection.
Autorzy :
Lee SH; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea.
Chu KB; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea.
Kang HJ; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea.
Basak S; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea.
Kim MJ; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea.
Park H; Health Park Co., Ltd., Seoul, Korea.
Jin H; Health Park Co., Ltd., Seoul, Korea.
Moon EK; Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul, Korea.
Quan FS; Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul, Korea.; Department of Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Graduate school, Kyung Hee University, Seoul, Korea.
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Źródło :
Parasite immunology [Parasite Immunol] 2020 Nov; Vol. 42 (11), pp. e12781. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunization*
Antigens, Protozoan/*immunology
Malaria/*parasitology
Malaria Vaccines/*immunology
Plasmodium berghei/*immunology
Protozoan Proteins/*immunology
Animals ; Antigens, Protozoan/genetics ; Female ; Mice ; Mice, Inbred BALB C ; Parasitemia ; Plasmodium berghei/genetics ; Plasmodium berghei/metabolism ; Protozoan Proteins/genetics
Czasopismo naukowe
Tytuł :
Plasmodium translocon component EXP2 facilitates hepatocyte invasion.
Autorzy :
Mello-Vieira J; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal.
Enguita FJ; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal.
de Koning-Ward TF; School of Medicine, Deakin University, Waurn Ponds, Geelong, Australia.
Zuzarte-Luís V; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal. .
Mota MM; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 06; Vol. 11 (1), pp. 5654. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hepatocytes/*parasitology
Liver/*parasitology
Malaria/*parasitology
Plasmodium berghei/*metabolism
Protozoan Proteins/*metabolism
Animals ; Humans ; Liver/cytology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Plasmodium berghei/genetics ; Plasmodium berghei/growth & development ; Protein Transport ; Protozoan Proteins/genetics ; Sporozoites/genetics ; Sporozoites/metabolism
Czasopismo naukowe
Tytuł :
Novel Harmicines with Improved Potency against Plasmodium .
Autorzy :
Marinović M; Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, HR-10 000 Zagreb, Croatia.
Perković I; Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, HR-10 000 Zagreb, Croatia.
Fontinha D; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.
Prudêncio M; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.
Held J; Institute of Tropical Medicine, University of Tübingen, Wilhelmstraße 27, 72074 Tübingen, Germany.
Pessanha de Carvalho L; Institute of Tropical Medicine, University of Tübingen, Wilhelmstraße 27, 72074 Tübingen, Germany.
Tandarić T; Computational Organic Chemistry and Biochemistry Group, Rudjer Bošković Institute, Bijenička cesta 54, HR-10 000 Zagreb, Croatia.
Vianello R; Computational Organic Chemistry and Biochemistry Group, Rudjer Bošković Institute, Bijenička cesta 54, HR-10 000 Zagreb, Croatia.
Zorc B; Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, HR-10 000 Zagreb, Croatia.
Rajić Z; Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, HR-10 000 Zagreb, Croatia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Sep 23; Vol. 25 (19). Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
Antimalarials/*pharmacology
Indole Alkaloids/*pharmacology
Plasmodium berghei/*drug effects
Plasmodium falciparum/*drug effects
Adenosine Triphosphate/metabolism ; Animals ; Female ; HSP90 Heat-Shock Proteins/chemistry ; HSP90 Heat-Shock Proteins/metabolism ; Liver/drug effects ; Liver/parasitology ; Molecular Dynamics Simulation ; Plasmodium berghei/metabolism ; Plasmodium berghei/physiology ; Plasmodium falciparum/metabolism ; Plasmodium falciparum/physiology ; Protein Conformation
Czasopismo naukowe
Tytuł :
Trichinella spiralis co-infection exacerbates Plasmodium berghei malaria-induced hepatopathy.
Autorzy :
Mei X; Artemisinin Research Center and Institute of Science and Technology, Guangzhou University of Chinese Medicine, Guangzhou, China.
Ye Z; Department of Parasitology, Zhongshan School of Medicine; Key Laboratory of Tropical Disease Control of Ministry of Education, Sun Yat-sen University, Guangzhou, China.
Chang Y; Artemisinin Research Center and Institute of Science and Technology, Guangzhou University of Chinese Medicine, Guangzhou, China.
Huang S; School of Stomatology, Jinan University, Guangzhou, China. .
Song J; Artemisinin Research Center and Institute of Science and Technology, Guangzhou University of Chinese Medicine, Guangzhou, China. .
Lu F; Department of Parasitology, Zhongshan School of Medicine; Key Laboratory of Tropical Disease Control of Ministry of Education, Sun Yat-sen University, Guangzhou, China. .
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Źródło :
Parasites & vectors [Parasit Vectors] 2020 Sep 03; Vol. 13 (1), pp. 440. Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Journal Article
MeSH Terms :
Coinfection*/immunology
Coinfection*/pathology
Plasmodium berghei*/immunology
Plasmodium berghei*/pathogenicity
Trichinella spiralis*/immunology
Trichinella spiralis*/pathogenicity
Liver/*pathology
Animals ; Blood Cell Count ; Cytokines/metabolism ; Disease Models, Animal ; Eosinophils/immunology ; Eosinophils/metabolism ; Galectins/metabolism ; Liver/parasitology ; Macrophages/immunology ; Macrophages/metabolism ; Malaria/immunology ; Malaria/pathology ; Mice ; Neutrophils/immunology ; Neutrophils/metabolism ; Parasitemia/pathology ; Spleen/parasitology ; Spleen/pathology ; Trichinellosis/immunology ; Trichinellosis/pathology
Czasopismo naukowe
Tytuł :
A Plasmodium homolog of ER tubule-forming proteins is required for parasite virulence.
Autorzy :
Shi X; Department of Immunology, School of Basic Medical Sciences, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China, Tianjin Medical University, Tianjin, China.
Hai L; Department of Immunology, School of Basic Medical Sciences, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China, Tianjin Medical University, Tianjin, China.
Govindasamy K; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, USA.
Gao J; Department of Immunology, School of Basic Medical Sciences, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China, Tianjin Medical University, Tianjin, China.
Coppens I; Department of Molecular Microbiology and Immunology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Hu J; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Wang Q; Department of Immunology, School of Basic Medical Sciences, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China, Tianjin Medical University, Tianjin, China.; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Bhanot P; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, USA.
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Źródło :
Molecular microbiology [Mol Microbiol] 2020 Sep; Vol. 114 (3), pp. 454-467. Date of Electronic Publication: 2020 Jun 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Malaria/*pathology
Membrane Transport Proteins/*metabolism
Plasmodium berghei/*genetics
Plasmodium berghei/*metabolism
Protozoan Proteins/*metabolism
Animals ; Cell Line ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum/ultrastructure ; Female ; Gene Knockout Techniques ; Genes, Protozoan ; Hep G2 Cells ; Humans ; Malaria/transmission ; Male ; Membrane Transport Proteins/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Microscopy, Electron, Transmission ; Movement ; Plasmodium berghei/ultrastructure ; Protein Transport ; Protozoan Proteins/genetics ; Rats ; Rats, Wistar ; Sporozoites/metabolism ; Virulence
Czasopismo naukowe
Tytuł :
Testing the impact of a single nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor on experimental cerebral malaria in mice.
Autorzy :
Akkaya M; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5625 Fishers Lane, Room 4S04, Rockville, MD, USA. .
Bansal A; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.; School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Sheehan PW; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5625 Fishers Lane, Room 4S04, Rockville, MD, USA.; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Pena M; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5625 Fishers Lane, Room 4S04, Rockville, MD, USA.
Cimperman CK; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5625 Fishers Lane, Room 4S04, Rockville, MD, USA.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA.
Qi CF; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5625 Fishers Lane, Room 4S04, Rockville, MD, USA.
Yazew T; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5625 Fishers Lane, Room 4S04, Rockville, MD, USA.; Department of Veterinary Medicine, College of Agriculture and Natural Resources, University of Maryland, College Park, MD, USA.
Otto TD; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Billker O; Laboratory for Molecular Infection Medicine Sweden and Molecular Biology Department, Umea University, Umea, Sweden.
Miller LH; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Pierce SK; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5625 Fishers Lane, Room 4S04, Rockville, MD, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 12; Vol. 10 (1), pp. 13630. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Polymorphism, Single Nucleotide*
CRISPR-Cas Systems/*genetics
Extracellular Matrix/*parasitology
Malaria, Cerebral/*parasitology
Plasmodium berghei/*genetics
Protozoan Proteins/*genetics
Virulence Factors/*genetics
Animals ; Female ; Mice ; Mice, Inbred C57BL ; Plasmodium berghei/growth & development ; Plasmodium berghei/physiology ; Protozoan Proteins/antagonists & inhibitors ; Virulence Factors/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Heparin Administered to Anopheles in Membrane Feeding Assays Blocks Plasmodium Development in the Mosquito.
Autorzy :
Lantero E; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Baldiri Reixac 10-12, ES-08028 Barcelona, Spain.; Barcelona Institute for Global Health (ISGlobal, Hospital Clínic-Universitat de Barcelona), Rosselló 149-153, ES-08036 Barcelona, Spain.
Fernandes J; Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT-NOVA), Rua da Junqueira 100, 1349-008 Lisbon, Portugal.
Aláez-Versón CR; BIOIBERICA S.A.U., Polígon Industrial 'Mas Puigvert', Ctra. N-II, km. 680.6, ES-08389 Palafolls, Spain.
Gomes J; Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT-NOVA), Rua da Junqueira 100, 1349-008 Lisbon, Portugal.
Silveira H; Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT-NOVA), Rua da Junqueira 100, 1349-008 Lisbon, Portugal.
Nogueira F; Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT-NOVA), Rua da Junqueira 100, 1349-008 Lisbon, Portugal.
Fernàndez-Busquets X; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Baldiri Reixac 10-12, ES-08028 Barcelona, Spain.; Barcelona Institute for Global Health (ISGlobal, Hospital Clínic-Universitat de Barcelona), Rosselló 149-153, ES-08036 Barcelona, Spain.; Nanoscience and Nanotechnology Institute (IN2UB, Universitat de Barcelona), Martí i Franquès 1, ES-08028 Barcelona, Spain.
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Źródło :
Biomolecules [Biomolecules] 2020 Aug 01; Vol. 10 (8). Date of Electronic Publication: 2020 Aug 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anopheles/*parasitology
Antimalarials/*pharmacology
Heparin/*pharmacology
Malaria/*prevention & control
Mosquito Vectors/*parasitology
Plasmodium berghei/*drug effects
Animals ; Anopheles/physiology ; Antimalarials/administration & dosage ; Diet ; Female ; Heparin/administration & dosage ; Malaria/transmission ; Mice ; Mosquito Vectors/physiology ; Oocysts/drug effects ; Plasmodium berghei/growth & development ; Plasmodium berghei/pathogenicity ; Zygote/drug effects
Czasopismo naukowe
Tytuł :
A lipocalin mediates unidirectional heme biomineralization in malaria parasites.
Autorzy :
Matz JM; Malaria Biochemistry Laboratory, The Francis Crick Institute, NW1 1AT London, United Kingdom; .; Department of Molecular Parasitology, Institute of Biology, Humboldt University, 10115 Berlin, Germany.
Drepper B; Department of Molecular Parasitology, Institute of Biology, Humboldt University, 10115 Berlin, Germany.
Blum TB; Laboratory of Nanoscale Biology, Division of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.
van Genderen E; Laboratory of Nanoscale Biology, Division of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Burrell A; Electron Microscopy Science Technology Platform, The Francis Crick Institute, NW1 1AT London, United Kingdom.
Martin P; Department of Molecular Parasitology, Institute of Biology, Humboldt University, 10115 Berlin, Germany.
Stach T; Department of Molecular Parasitology, Institute of Biology, Humboldt University, 10115 Berlin, Germany.
Collinson LM; Electron Microscopy Science Technology Platform, The Francis Crick Institute, NW1 1AT London, United Kingdom.
Abrahams JP; Laboratory of Nanoscale Biology, Division of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.; Center for Cellular Imaging and NanoAnalytics, Biozentrum, University of Basel, 4051 Basel, Switzerland.; Institute of Biology, Leiden University, 2311 EZ Leiden, The Netherlands.
Matuschewski K; Department of Molecular Parasitology, Institute of Biology, Humboldt University, 10115 Berlin, Germany.
Blackman MJ; Malaria Biochemistry Laboratory, The Francis Crick Institute, NW1 1AT London, United Kingdom.; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, WC1E 7HT London, United Kingdom.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 14; Vol. 117 (28), pp. 16546-16556. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Heme/*metabolism
Lipocalins/*metabolism
Malaria/*parasitology
Plasmodium berghei/*metabolism
Plasmodium falciparum/*metabolism
Protozoan Proteins/*metabolism
Amino Acid Sequence ; Animals ; Hemeproteins/genetics ; Hemeproteins/metabolism ; Humans ; Lipocalins/chemistry ; Lipocalins/genetics ; Malaria/metabolism ; Mice ; Plasmodium berghei/chemistry ; Plasmodium berghei/genetics ; Plasmodium falciparum/chemistry ; Plasmodium falciparum/genetics ; Protozoan Proteins/chemistry ; Protozoan Proteins/genetics
Czasopismo naukowe
Tytuł :
Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP.
Autorzy :
Klug D; Integrative Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Heidelberg, Germany.; Université de Strasbourg, CNRS UPR9022, INSERM U963, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.
Goellner S; Integrative Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Heidelberg, Germany.; Department of Molecular Virology, Heidelberg University Medical School, Heidelberg, Germany.
Kehrer J; Integrative Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Heidelberg, Germany.
Sattler J; Integrative Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Heidelberg, Germany.
Strauss L; Integrative Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Heidelberg, Germany.
Singer M; Integrative Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Heidelberg, Germany.; Experimental Parasitology, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, München, Germany.
Lu C; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, United States.
Springer TA; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, United States.
Frischknecht F; Integrative Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Heidelberg, Germany.
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Źródło :
ELife [Elife] 2020 Jul 10; Vol. 9. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji :
Journal Article
MeSH Terms :
Anopheles/*parasitology
Malaria/*parasitology
Plasmodium berghei/*genetics
Protozoan Proteins/*genetics
Amino Acid Sequence ; Animals ; Evolution, Molecular ; Female ; Ligands ; Mice ; Mice, Inbred C57BL ; Plasmodium berghei/metabolism ; Protozoan Proteins/chemistry ; Protozoan Proteins/metabolism ; Salivary Glands/parasitology ; Sequence Alignment ; Sporozoites/physiology
Czasopismo naukowe
Tytuł :
A Plasmodium cysteine protease required for efficient transition from the liver infection stage.
Autorzy :
Putrianti ED; Parasitology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.; Metabolism of Microbial Pathogens, Robert Koch Institute, Berlin, Germany.
Schmidt-Christensen A; Department of Experimental Medical Science, Lund University, Lund, Sweden.; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Heussler V; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; Institute of Cell Biology, University of Bern, Bern, Switzerland.
Matuschewski K; Parasitology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.; Department of Molecular Parasitology, Institute of Biology, Humboldt University Berlin, Berlin, Germany.
Ingmundson A; Parasitology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.; Department of Molecular Parasitology, Institute of Biology, Humboldt University Berlin, Berlin, Germany.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 21; Vol. 16 (9), pp. e1008891. Date of Electronic Publication: 2020 Sep 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cysteine Proteases/*metabolism
Liver/*parasitology
Malaria/*enzymology
Plasmodium berghei/*enzymology
Protozoan Proteins/*metabolism
Animals ; Cysteine Proteases/genetics ; Liver/metabolism ; Malaria/genetics ; Mice ; Plasmodium berghei/genetics ; Protozoan Proteins/genetics ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Analysis of spleen histopathology, splenocyte composition and haematological parameters in four strains of mice infected with Plasmodium berghei K173.
Autorzy :
Wang, Huajing (AUTHOR)
Li, Shuo (AUTHOR)
Cui, Zhao (AUTHOR)
Qin, Tingting (AUTHOR)
Shi, Hang (AUTHOR)
Ma, Ji (AUTHOR)
Li, Lanfang (AUTHOR)
Yu, Guihua (AUTHOR)
Jiang, Tingliang (AUTHOR)
Li, Canghai (AUTHOR)
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Źródło :
Malaria Journal. 6/5/2021, Vol. 20 Issue 1, p1-12. 12p.
Czasopismo naukowe
Tytuł :
Phytol suppresses parasitemia and ameliorates anaemia and oxidative brain damage in mice infected with Plasmodium berghei.
Autorzy :
Usman MA; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria. Electronic address: .
Usman FI; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
Abubakar MS; University Medical Centre, Ahmadu Bello University, Zaria, Nigeria.
Salman AA; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
Adamu A; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
Ibrahim MA; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
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Źródło :
Experimental parasitology [Exp Parasitol] 2021 May; Vol. 224, pp. 108097. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article
MeSH Terms :
Malaria/*drug therapy
Phytol/*therapeutic use
Plasmodium berghei/*drug effects
Analysis of Variance ; Anemia/drug therapy ; Anemia/parasitology ; Animals ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Brain/parasitology ; Brain/pathology ; Chloroquine/pharmacology ; Chloroquine/therapeutic use ; Dose-Response Relationship, Drug ; Female ; Hematocrit ; Liver/parasitology ; Liver/pathology ; Malaria/blood ; Malaria/parasitology ; Malaria/pathology ; Male ; Mice ; Oxidation-Reduction/drug effects ; Parasitemia/drug therapy ; Phytol/pharmacology ; Random Allocation ; Spleen/parasitology ; Spleen/pathology
Czasopismo naukowe
Tytuł :
Antimalarial activity of the aqueous extract of the latex of Aloe pirottae Berger. (Aloaceae) against Plasmodium berghei in mice.
Autorzy :
Dibessa TT; Wollega University, Institute of Health Sciences, Department of Pharmacy, Ethiopia. Electronic address: .
Engidawork E; Addis Ababa University, School of Pharmacy, Department of Pharmacology and Clinical Pharmacy, Ethiopia. Electronic address: .
Nedi T; Addis Ababa University, School of Pharmacy, Department of Pharmacology and Clinical Pharmacy, Ethiopia. Electronic address: .
Teklehaymanot T; Addis Ababa University, Aklilu Lemma Institute of Pathobiology, Ethiopia. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2020 Jun 12; Vol. 255, pp. 112763. Date of Electronic Publication: 2020 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Aloe*/chemistry
Aloe*/toxicity
Antimalarials/*pharmacology
Erythrocytes/*parasitology
Latex/*pharmacology
Malaria/*drug therapy
Plant Extracts/*pharmacology
Plasmodium berghei/*drug effects
Animals ; Antimalarials/isolation & purification ; Antimalarials/toxicity ; Body Temperature Regulation/drug effects ; Disease Models, Animal ; Female ; Latex/isolation & purification ; Latex/toxicity ; Malaria/blood ; Malaria/parasitology ; Male ; Mice ; Parasite Load ; Parasitemia/blood ; Parasitemia/drug therapy ; Parasitemia/parasitology ; Plant Extracts/isolation & purification ; Plant Extracts/toxicity ; Plant Leaves ; Plasmodium berghei/pathogenicity ; Weight Loss/drug effects
Czasopismo naukowe
Tytuł :
G-strand binding protein 2 is involved in asexual and sexual development of Plasmodium berghei.
Autorzy :
Niikura M; Department of Infectious Diseases, Kyorin University School of Medicine, Tokyo, Japan. Electronic address: .
Fukutomi T; Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan.
Fukui K; Department of Infectious Diseases, Kyorin University School of Medicine, Tokyo, Japan.
Inoue SI; Division of Immunology, Department of Molecular Microbiology and Immunology, Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan.
Asahi H; Department of Infectious Diseases, Kyorin University School of Medicine, Tokyo, Japan.
Kobayashi F; Department of Environmental Science, School of Life and Environmental Science, Azabu University, Japan.
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Źródło :
Parasitology international [Parasitol Int] 2020 Jun; Vol. 76, pp. 102059. Date of Electronic Publication: 2020 Jan 18.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Malaria, Cerebral/*parasitology
Plasmodium berghei/*genetics
Plasmodium berghei/*growth & development
Protozoan Proteins/*genetics
Animals ; Erythrocytes/parasitology ; Female ; Gene Deletion ; Mice ; Mice, Inbred C57BL ; Plasmodium berghei/pathogenicity ; Proteomics ; Purine Nucleotides/biosynthesis ; Specific Pathogen-Free Organisms
Czasopismo naukowe
Tytuł :
Broad spectrum immunomodulatory effects of Anopheles gambiae microRNAs and their use for transgenic suppression of Plasmodium.
Autorzy :
Dong S; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America.
Fu X; The Interdisciplinary Ph.D. Program in Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, VA, United States of America.
Dong Y; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America.
Simões ML; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America.
Zhu J; Department of Biochemistry, Virginia Tech, Blacksburg, VA, United States of America.
Dimopoulos G; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Apr 24; Vol. 16 (4), pp. e1008453. Date of Electronic Publication: 2020 Apr 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anopheles/*immunology
Malaria, Falciparum/*parasitology
MicroRNAs/*immunology
Mosquito Vectors/*immunology
Plasmodium berghei/*physiology
Plasmodium falciparum/*physiology
Animals ; Anopheles/genetics ; Anopheles/parasitology ; Female ; MicroRNAs/genetics ; Mosquito Vectors/genetics ; Mosquito Vectors/parasitology ; Plasmodium berghei/genetics ; Plasmodium berghei/immunology ; Plasmodium falciparum/genetics ; Plasmodium falciparum/immunology
Czasopismo naukowe
Tytuł :
Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines.
Autorzy :
Priebbenow DL; School of Chemistry, The University of Melbourne, Parkville, VIC 3010, Australia.
Mathiew M; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Shi DH; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Harjani JR; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Beveridge JG; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Chavchich M; The Department of Drug Evaluation, Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, QLD 4051, Australia.
Edstein MD; The Department of Drug Evaluation, Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, QLD 4051, Australia.
Duffy S
Avery VM
Jacobs RT; Medicines for Malaria Venture (MMV), P.O. Box 1826, Route de Pré-Bois 20, CH-1215 Geneva, Switzerland.
Brand S; Medicines for Malaria Venture (MMV), P.O. Box 1826, Route de Pré-Bois 20, CH-1215 Geneva, Switzerland.
Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Wang W; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Zhong L; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Lee G; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Tay E; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Barker H; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Crighton E; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
De Paoli A; Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Creek DJ; Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Baell JB; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.; ARC Centre for Fragment-Based Design, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 4150-4162. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antimalarials/*therapeutic use
Malaria/*drug therapy
Triazines/*therapeutic use
Animals ; Antimalarials/chemical synthesis ; Antimalarials/pharmacokinetics ; Caco-2 Cells ; Female ; Humans ; Male ; Mice, Inbred NOD ; Mice, SCID ; Microsomes, Liver/drug effects ; Molecular Structure ; Parasitic Sensitivity Tests ; Plasmodium berghei/drug effects ; Plasmodium falciparum/drug effects ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Triazines/chemical synthesis ; Triazines/pharmacokinetics
Czasopismo naukowe

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