Noninvasive assessment of gut function using transcriptional recording sentinel cells.
Autorzy:
Schmidt F; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland. Zimmermann J; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.; Department for Biomedical Research, University of Bern, Bern, Switzerland. Tanna T; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.; Department of Computer Science, ETH Zurich, Universitätstrasse 6, 8092 Zurich, Switzerland. Farouni R; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland. Conway T; Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078, USA. Macpherson AJ; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.; Botnar Research Center for Child Health, Mattenstrasse 24a, 4058 Basel, Switzerland.; Department for Biomedical Research, University of Bern, Bern, Switzerland. PlattRJ; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.; Botnar Research Center for Child Health, Mattenstrasse 24a, 4058 Basel, Switzerland.; Department of Chemistry, University of Basel, Petersplatz 1, 4003 Basel, Switzerland.
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Źródło:
Science (New York, N.Y.) [Science] 2022 May 13; Vol. 376 (6594), pp. eabm6038. Date of Electronic Publication: 2022 May 13.
Therapeutic genome editing: prospects and challenges.
Autorzy:
Cox DB; 1] Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [2] Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [4] McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts, USA. PlattRJ; 1] Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [2] McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts, USA. [3] Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [4] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. Zhang F; 1] Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [2] McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts, USA. [3] Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [4] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Feb; Vol. 21 (2), pp. 121-31.
Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum.
Autorzy:
Wagner JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. PlattRJ; 1] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. Goldfless SJ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. Zhang F; 1] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [3] McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [4] Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
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Źródło:
Nature methods [Nat Methods] 2014 Sep; Vol. 11 (9), pp. 915-8. Date of Electronic Publication: 2014 Aug 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Optical control of mammalian endogenous transcription and epigenetic states.
Autorzy:
Konermann S; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Brigham MD; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; School of Engineering and Applied Sciences, Harvard University Cambridge, MA 02138, USA. Trevino A; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Hsu PD; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Heidenreich M; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Cong L; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. PlattRJ; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Scott DA; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Church GM; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Zhang F; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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Źródło:
Nature [Nature] 2013 Aug 22; Vol. 500 (7463), pp. 472-476. Date of Electronic Publication: 2013 Aug 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
CD8+ T Lymphocyte Epitopes From The Herpes Simplex Virus Type 2 ICP27, VP22 and VP13/14 Proteins To Facilitate Vaccine Design And Characterization.
Autorzy:
PlattRJ; Biotherapeutics and Translational Research, Pharmacokinetics, Dynamics & Metabolism, Pfizer Global Research and Development, Sandwich, Kent, CT13-9NJ, UK. Rebecca.Platt@Covance.com. Khodai T; New Opportunities Unit, Pfizer Global Research and Development, Sandwich, Kent, CT13 -9NJ, UK. . Townend TJ; Biotherapeutics and Translational Research, Pharmacokinetics, Dynamics & Metabolism, Pfizer Global Research and Development, Sandwich, Kent, CT13-9NJ, UK. . Bright HH; New Opportunities Unit, Pfizer Global Research and Development, Sandwich, Kent, CT13 -9NJ, UK. . Cockle P; Vaccine Research Unit, Pfizer Global Research and Development, Sandwich, Kent, CT13-9NJ, UK. . Perez-Tosar L; Biotherapeutics and Translational Research, Pharmacokinetics, Dynamics & Metabolism, Pfizer Global Research and Development, Sandwich, Kent, CT13-9NJ, UK. . Webster R; Biotherapeutics and Translational Research, Pharmacokinetics, Dynamics & Metabolism, Pfizer Global Research and Development, Sandwich, Kent, CT13-9NJ, UK. . Champion B; Vaccine Research Unit, Pfizer Global Research and Development, Sandwich, Kent, CT13-9NJ, UK. . Hickling TP; Biotherapeutics and Translational Research, Pharmacokinetics, Dynamics & Metabolism, Pfizer Global Research and Development, Sandwich, Kent, CT13-9NJ, UK. . Mirza F; Biotherapeutics and Translational Research, Pharmacokinetics, Dynamics & Metabolism, Pfizer Global Research and Development, Sandwich, Kent, CT13-9NJ, UK. .
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Źródło:
Cells [Cells] 2013 Jan 04; Vol. 2 (1), pp. 19-42. Date of Electronic Publication: 2013 Jan 04.
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