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Wyszukujesz frazę ""Poly\(ADP-ribose\) Polymerases"" wg kryterium: Temat


Tytuł :
PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling.
Autorzy :
van Beek L; Structure and Biophysics, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
McClay É; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Garscube Campus, University of Glasgow, Glasgow G61 1QQ, UK.
Patel S; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
Schimpl M; Structure and Biophysics, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
Spagnolo L; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Garscube Campus, University of Glasgow, Glasgow G61 1QQ, UK.
Maia de Oliveira T; Structure and Biophysics, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 12; Vol. 22 (10). Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Cycle Proteins/*chemistry
Nucleosomes/*metabolism
Poly (ADP-Ribose) Polymerase-1/*chemistry
Poly(ADP-ribose) Polymerases/*chemistry
Allosteric Regulation/drug effects ; Carrier Proteins/metabolism ; Cell Cycle Proteins/metabolism ; DNA Repair ; Humans ; Models, Molecular ; Nuclear Proteins/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerases/metabolism ; Protein Domains/drug effects
Czasopismo naukowe
Tytuł :
PARP Activity Fine-tunes the DNA Replication Choreography of Chk1-depleted Cells.
Autorzy :
Luis Calzetta N; Fundación Instituto Leloir - Instituto de Investigaciones Bioquímicas de Buenos Aires, Consejo de Investigaciones Científicas y Técnicas, Avenida Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina.
Alejandra González Besteiro M; Fundación Instituto Leloir - Instituto de Investigaciones Bioquímicas de Buenos Aires, Consejo de Investigaciones Científicas y Técnicas, Avenida Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina. Electronic address: .
Gottifredi V; Fundación Instituto Leloir - Instituto de Investigaciones Bioquímicas de Buenos Aires, Consejo de Investigaciones Científicas y Técnicas, Avenida Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 May 14; Vol. 433 (10), pp. 166949. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Replication*
Checkpoint Kinase 1/*genetics
Poly(ADP-ribose) Polymerases/*genetics
Cell Line, Tumor ; Checkpoint Kinase 1/antagonists & inhibitors ; Checkpoint Kinase 1/metabolism ; Gene Expression Regulation ; Humans ; Osteoblasts/cytology ; Osteoblasts/drug effects ; Osteoblasts/enzymology ; Phthalazines/pharmacology ; Piperazines/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerases/metabolism ; Protein Kinase Inhibitors/pharmacology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Roscovitine/pharmacology ; Thymidine/analogs & derivatives ; Thymidine/pharmacology
Czasopismo naukowe
Tytuł :
Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly.
Autorzy :
Yang CS; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
Jividen K; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.
Kamata T; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
Dworak N; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.
Oostdyk L; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
Remlein B; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
Pourfarjam Y; Department of Chemistry, University of Cincinnati, Cincinnati, OH, USA.
Kim IK; Department of Chemistry, University of Cincinnati, Cincinnati, OH, USA.
Du KP; Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA.
Abbas T; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.; Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA.
Sherman NE; W. M. Keck Biomedical Mass Spectrometry Laboratory, University of Virginia, Charlottesville, VA, USA.
Wotton D; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
Paschal BM; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA. .; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 11; Vol. 12 (1), pp. 2705. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Protein Processing, Post-Translational*
Neoplasm Proteins/*genetics
Poly(ADP-ribose) Polymerases/*genetics
Prostatic Neoplasms/*genetics
Receptors, Androgen/*genetics
ADP-Ribosylation/drug effects ; Adenocarcinoma ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Humans ; Male ; Metribolone/pharmacology ; Neoplasm Proteins/metabolism ; Phthalazines/pharmacology ; Piperazines/pharmacology ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerases/metabolism ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Receptors, Androgen/metabolism ; Signal Transduction ; Survival Analysis
Czasopismo naukowe
Tytuł :
Functional Roles of PARP2 in Assembling Protein-Protein Complexes Involved in Base Excision DNA Repair.
Autorzy :
Vasil'eva I; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Moor N; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Anarbaev R; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kutuzov M; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Lavrik O; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 28; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 28.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Repair/*physiology
Poly(ADP-ribose) Polymerases/*physiology
DNA/chemistry ; DNA Damage/physiology ; DNA Polymerase beta/genetics ; DNA Repair/genetics ; DNA-(Apurinic or Apyrimidinic Site) Lyase/genetics ; Humans ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly ADP Ribosylation/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; Protein Interaction Maps ; X-ray Repair Cross Complementing Protein 1/metabolism
Czasopismo naukowe
Tytuł :
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
Autorzy :
Hewitt G; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Borel V; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Segura-Bayona S; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Takaki T; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Ruis P; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Bellelli R; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Lehmann LC; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, 75124 Uppsala, Sweden.
Sommerova L; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Vancevska A; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Tomas-Loba A; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Zhu K; Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford OX1 3RE, UK.
Cooper C; Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford OX1 3RE, UK.
Fugger K; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Patel H; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Goldstone R; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Schneider-Luftman D; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Herbert E; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Stamp G; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Brough R; The CRUK Gene Function Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Pettitt S; The CRUK Gene Function Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Lord CJ; The CRUK Gene Function Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
West SC; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Ahel I; Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford OX1 3RE, UK.
Ahel D; Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford OX1 3RE, UK.
Chapman JR; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Deindl S; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, 75124 Uppsala, Sweden.
Boulton SJ; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Artios Pharma Ltd., Meditrina, Babraham Research Campus, Cambridge CB22 3AT, UK. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 18; Vol. 81 (4), pp. 767-783.e11. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin Assembly and Disassembly*
DNA Helicases/*metabolism
DNA-Binding Proteins/*metabolism
Neoplasm Proteins/*metabolism
Neoplasms, Experimental/*metabolism
Nucleosomes/*metabolism
Poly(ADP-ribose) Polymerases/*metabolism
Animals ; DNA Helicases/genetics ; DNA Replication/drug effects ; DNA-(Apurinic or Apyrimidinic Site) Lyase/genetics ; DNA-(Apurinic or Apyrimidinic Site) Lyase/metabolism ; DNA-Binding Proteins/genetics ; Homologous Recombination/drug effects ; Mice ; Mice, Knockout ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/genetics ; Neoplasms, Experimental/genetics ; Nucleosomes/genetics ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerases/genetics
Czasopismo naukowe
Tytuł :
Identifying new piperazine-based PARP1 inhibitors using text mining and integrated molecular modeling approaches.
Autorzy :
Sahin K; Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey.
Durdagi S; Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Feb; Vol. 39 (2), pp. 681-690. Date of Electronic Publication: 2020 Feb 12.
Typ publikacji :
Journal Article
MeSH Terms :
Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology
Poly(ADP-ribose) Polymerases*
Data Mining ; Piperazine ; Piperazines
Czasopismo naukowe
Tytuł :
Fluorescent detection of PARP activity in unfixed tissue.
Autorzy :
Belhadj S; Cell Death Mechanism Group, Institute for Ophthalmic Research, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.
Rentsch A; Biolog Life Science Institute GmbH & Co. KG, Bremen, Germany.
Schwede F; Biolog Life Science Institute GmbH & Co. KG, Bremen, Germany.
Paquet-Durand F; Cell Death Mechanism Group, Institute for Ophthalmic Research, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.
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Źródło :
PloS one [PLoS One] 2021 Jan 22; Vol. 16 (1), pp. e0245369. Date of Electronic Publication: 2021 Jan 22 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Assays/*methods
Fluorescent Dyes/*analysis
Microscopy, Fluorescence/*methods
Poly(ADP-ribose) Polymerases/*analysis
Retina/*enzymology
Animals ; Fluorescent Dyes/metabolism ; Mice ; NAD/analogs & derivatives ; NAD/analysis ; NAD/metabolism ; Poly(ADP-ribose) Polymerases/metabolism ; Retina/metabolism ; Retinal Degeneration/metabolism ; Retinal Degeneration/pathology
Czasopismo naukowe
Tytuł :
PARP inhibitor resistance and TP53 mutations in patients treated with olaparib for BRCA-mutated cancer: Four case reports.
Autorzy :
Collot T; Department of Oncology, Georges-François Leclerc Cancer Center, UNICANCER, F-21079 Dijon, France.
Niogret J; Department of Oncology, Georges-François Leclerc Cancer Center, UNICANCER, F-21079 Dijon, France.
Carnet M; Molecular Biology Unit, Department of Biology and Pathology of Tumors, Georges-François Leclerc Cancer Center, UNICANCER, F-21079 Dijon, France.
Chevrier S; Molecular Biology Unit, Department of Biology and Pathology of Tumors, Georges-François Leclerc Cancer Center, UNICANCER, F-21079 Dijon, France.
Humblin E; Centre de Recherche, University Bourgogne Franche-Comté, F-21078 Dijon, France.
Favier L; Department of Oncology, Georges-François Leclerc Cancer Center, UNICANCER, F-21079 Dijon, France.
Bengrine-Lefevre L; Department of Oncology, Georges-François Leclerc Cancer Center, UNICANCER, F-21079 Dijon, France.
Desmoulins I; Department of Oncology, Georges-François Leclerc Cancer Center, UNICANCER, F-21079 Dijon, France.
Arnould L; Pathology Unit, Department of Biology and Pathology of Tumors, Georges-François Leclerc Cancer Center, UNICANCER, F-21079 Dijon, France.
Boidot R; Molecular Biology Unit, Department of Biology and Pathology of Tumors, Georges-François Leclerc Cancer Center, UNICANCER, F-21079 Dijon, France.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Jan; Vol. 23 (1). Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Loss of Function Mutation*
BRCA1 Protein/*metabolism
Drug Resistance, Neoplasm/*drug effects
Ovarian Neoplasms/*drug therapy
Phthalazines/*pharmacology
Piperazines/*pharmacology
Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology
Poly(ADP-ribose) Polymerases/*metabolism
Tumor Suppressor Protein p53/*metabolism
Aged ; BRCA1 Protein/genetics ; Drug Resistance, Neoplasm/genetics ; Female ; HCT116 Cells ; Humans ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Poly(ADP-ribose) Polymerases/genetics ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.
Autorzy :
Gaullier G; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO, United States of America.
Roberts G; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
Muthurajan UM; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO, United States of America.
Bowerman S; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO, United States of America.
Rudolph J; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO, United States of America.
Mahadevan J; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
Jha A; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
Rae PS; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
Luger K; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Nov 03; Vol. 15 (11), pp. e0240932. Date of Electronic Publication: 2020 Nov 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
Carrier Proteins/*metabolism
Nuclear Proteins/*metabolism
Poly(ADP-ribose) Polymerases/*metabolism
Amino Acid Substitution ; Carrier Proteins/chemistry ; Carrier Proteins/genetics ; Cryoelectron Microscopy ; Humans ; In Vitro Techniques ; Models, Molecular ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Nucleosomes/metabolism ; Nucleosomes/ultrastructure ; Point Mutation ; Poly(ADP-ribose) Polymerases/chemistry ; Poly(ADP-ribose) Polymerases/genetics ; Protein Binding ; Protein Conformation ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential.
Autorzy :
Rack JGM; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Zorzini V; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Zhu Z; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Schuller M; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Ahel D; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Ahel I; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
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Źródło :
Open biology [Open Biol] 2020 Nov; Vol. 10 (11), pp. 200237. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
ADP-Ribosylation*
Molecular Docking Simulation*
Poly(ADP-ribose) Polymerases/*chemistry
RNA-Dependent RNA Polymerase/*chemistry
Viral Nonstructural Proteins/*chemistry
Adenosine Diphosphate Ribose/chemistry ; Adenosine Diphosphate Ribose/metabolism ; Binding Sites ; Evolution, Molecular ; Humans ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; Protein Binding ; Protein Domains ; RNA-Dependent RNA Polymerase/genetics ; RNA-Dependent RNA Polymerase/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity.
Autorzy :
Heer CD; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA; Department of Biochemistry, University of Iowa, Iowa City, Iowa, USA.
Sanderson DJ; Department of Chemical Physiology & Biochemistry, Oregon Health Sciences University, Portland, Oregon, USA.
Voth LS; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Alhammad YMO; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Schmidt MS; Department of Biochemistry, University of Iowa, Iowa City, Iowa, USA.
Trammell SAJ; Department of Biochemistry, University of Iowa, Iowa City, Iowa, USA.
Perlman S; Department of Microbiology & Immunology, University of Iowa, Iowa City, Iowa, USA.
Cohen MS; Department of Chemical Physiology & Biochemistry, Oregon Health Sciences University, Portland, Oregon, USA.
Fehr AR; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA. Electronic address: .
Brenner C; Department of Biochemistry, University of Iowa, Iowa City, Iowa, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 25; Vol. 295 (52), pp. 17986-17996. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
COVID-19/*metabolism
NAD/*immunology
Poly(ADP-ribose) Polymerases/*immunology
SARS-CoV-2/*immunology
A549 Cells ; ADP-Ribosylation ; Adenosine Diphosphate Ribose/metabolism ; Adult ; Animals ; COVID-19/immunology ; Cell Line, Tumor ; Female ; Ferrets ; Humans ; Immunity, Innate ; Male ; Metabolome ; Mice ; Mice, Inbred C57BL ; NAD/metabolism ; Niacinamide/analogs & derivatives ; Niacinamide/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerases/blood ; SARS-CoV-2/metabolism
Czasopismo naukowe
Tytuł :
The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks.
Autorzy :
Blessing C; Department of Physiological Chemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Planegg-Martinsried, Germany; International Max Planck Research School (IMPRS) for Molecular Life Sciences, 82152 Planegg-Martinsried, Germany.
Mandemaker IK; Department of Physiological Chemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Planegg-Martinsried, Germany.
Gonzalez-Leal C; Department of Physiological Chemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Planegg-Martinsried, Germany; International Max Planck Research School (IMPRS) for Molecular Life Sciences, 82152 Planegg-Martinsried, Germany.
Preisser J; Department of Physiological Chemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Planegg-Martinsried, Germany.
Schomburg A; Department of Physiological Chemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Planegg-Martinsried, Germany; Eisbach Bio GmbH, Am Klopferspitz 19, 82152 Planegg-Martinsried, Germany.
Ladurner AG; Department of Physiological Chemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Planegg-Martinsried, Germany; International Max Planck Research School (IMPRS) for Molecular Life Sciences, 82152 Planegg-Martinsried, Germany; Eisbach Bio GmbH, Am Klopferspitz 19, 82152 Planegg-Martinsried, Germany. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Dec 03; Vol. 80 (5), pp. 862-875.e6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Single-Stranded*
DNA Helicases/*metabolism
DNA-Binding Proteins/*metabolism
Neoplasms/*enzymology
Poly(ADP-ribose) Polymerase Inhibitors/*metabolism
Poly(ADP-ribose) Polymerases/*metabolism
Proto-Oncogene Proteins/*metabolism
Cell Line, Tumor ; DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly(ADP-ribose) Polymerases/genetics ; Proto-Oncogene Proteins/genetics
Czasopismo naukowe
Tytuł :
Regulation of ALT-associated homology-directed repair by polyADP-ribosylation.
Autorzy :
Hoang SM; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Kaminski N; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Bhargava R; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Barroso-González J; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Lynskey ML; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
García-Expósito L; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Roncaioli JL; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Wondisford AR; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Wallace CT; Department of Cell Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Watkins SC; Department of Cell Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
James DI; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, Macclesfield, UK.
Waddell ID; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, Macclesfield, UK.
Ogilvie D; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, Macclesfield, UK.
Smith KM; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, Macclesfield, UK.
da Veiga Leprevost F; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Mellacharevu D; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Nesvizhskii AI; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Li J; Department of Pharmacology and the Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
Ray-Gallet D; Institut Curie, PSL Research University, CNRS, Sorbonne Université, Nuclear Dynamics Unit, Equipe Labellisée, Ligue contre le Cancer, Paris, France.
Sobol RW; Department of Pharmacology and the Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
Almouzni G; Institut Curie, PSL Research University, CNRS, Sorbonne Université, Nuclear Dynamics Unit, Equipe Labellisée, Ligue contre le Cancer, Paris, France.
O'Sullivan RJ; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Dec; Vol. 27 (12), pp. 1152-1164. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Protein Processing, Post-Translational*
Recombinational DNA Repair*
DNA, Neoplasm/*genetics
Glycoside Hydrolases/*genetics
Poly(ADP-ribose) Polymerases/*genetics
Telomere/*metabolism
Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Chromatin/metabolism ; Chromatin/ultrastructure ; DNA Damage ; DNA, Neoplasm/metabolism ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; G2 Phase ; Glycoside Hydrolases/metabolism ; HeLa Cells ; Histone Chaperones/antagonists & inhibitors ; Histone Chaperones/genetics ; Histone Chaperones/metabolism ; Histones/genetics ; Histones/metabolism ; Humans ; Poly ADP Ribosylation ; Poly Adenosine Diphosphate Ribose/metabolism ; Poly(ADP-ribose) Polymerases/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; Telomere/ultrastructure ; Telomere Homeostasis ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/genetics ; Transcription Factors/metabolism ; X-linked Nuclear Protein/genetics ; X-linked Nuclear Protein/metabolism
Czasopismo naukowe
Tytuł :
Smyd3-PARP16 axis accelerates unfolded protein response and vascular aging.
Autorzy :
Yang D; Department of Pharmacology, Human Phenome Institute, School of Pharmacy, Fudan University, Shanghai, P.R. China.; State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau, P.R. China.; Shanghai Key Laboratory of Bioactive Small Molecules and Research Center on Aging and Medicine, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, P.R. China.
Wang Q; Department of Pharmacology, Human Phenome Institute, School of Pharmacy, Fudan University, Shanghai, P.R. China.
Wei G; State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences and Huashan Hospital, Fudan University, Shanghai, P.R. China.
Wu J; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China.
Zhu YC; Shanghai Key Laboratory of Bioactive Small Molecules and Research Center on Aging and Medicine, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, P.R. China.
Zhu Q; School of Pharmacy, Nantong University, Nantong, P.R. China.
Ni T; State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences and Huashan Hospital, Fudan University, Shanghai, P.R. China.
Liu X; Department of Pharmacology, Human Phenome Institute, School of Pharmacy, Fudan University, Shanghai, P.R. China.
Zhu YZ; Department of Pharmacology, Human Phenome Institute, School of Pharmacy, Fudan University, Shanghai, P.R. China.; State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau, P.R. China.; Shanghai Key Laboratory of Bioactive Small Molecules and Research Center on Aging and Medicine, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, P.R. China.
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Źródło :
Aging [Aging (Albany NY)] 2020 Nov 03; Vol. 12 (21), pp. 21423-21445. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*/drug effects
Unfolded Protein Response*/drug effects
Aorta, Thoracic/*enzymology
Endothelial Cells/*enzymology
Poly(ADP-ribose) Polymerases/*metabolism
Angiotensin II/toxicity ; Animals ; Aorta, Thoracic/drug effects ; Aorta, Thoracic/pathology ; Binding Sites ; Cells, Cultured ; DNA Methylation ; Endothelial Cells/drug effects ; Endothelial Cells/pathology ; Epigenesis, Genetic ; Gene Expression Regulation ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Male ; Mice, Inbred C57BL ; Poly(ADP-ribose) Polymerases/genetics ; Promoter Regions, Genetic ; Rats ; Signal Transduction
Czasopismo naukowe
Tytuł :
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N -methyladenosine methylation of Parp10 mRNA.
Autorzy :
Gao XQ; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Zhang YH; State Key Laboratory of Cardiovascular Disease, Heart Failure Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Liu F; Center of Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, and Department of Anatomy, Guilin Medical University, Guilin, China.
Ponnusamy M; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Zhao XM; State Key Laboratory of Cardiovascular Disease, Heart Failure Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Zhou LY; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Zhai M; State Key Laboratory of Cardiovascular Disease, Heart Failure Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Liu CY; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Li XM; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Wang M; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Shan C; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Shan PP; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Wang Y; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Dong YH; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Qian LL; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Yu T; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Ju J; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Wang T; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Wang K; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Chen XZ; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Wang YH; State Key Laboratory of Cardiovascular Disease, Heart Failure Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Zhang J; State Key Laboratory of Cardiovascular Disease, Heart Failure Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Li PF; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Wang K; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China. .
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Źródło :
Nature cell biology [Nat Cell Biol] 2020 Nov; Vol. 22 (11), pp. 1319-1331. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ventricular Function, Left*
Adenosine/*analogs & derivatives
Heart Ventricles/*enzymology
Hypertrophy, Left Ventricular/*enzymology
Methyltransferases/*metabolism
Myocytes, Cardiac/*enzymology
Poly(ADP-ribose) Polymerases/*metabolism
Proto-Oncogene Proteins/*metabolism
RNA, Messenger/*metabolism
RNA, Small Interfering/*metabolism
Adenosine/metabolism ; Animals ; Cells, Cultured ; Disease Models, Animal ; Gene Expression Regulation, Enzymologic ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Heart Ventricles/pathology ; Hypertrophy, Left Ventricular/genetics ; Hypertrophy, Left Ventricular/pathology ; Hypertrophy, Left Ventricular/physiopathology ; Male ; Methylation ; Methyltransferases/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; Myocytes, Cardiac/pathology ; NFATC Transcription Factors/genetics ; NFATC Transcription Factors/metabolism ; Poly(ADP-ribose) Polymerases/genetics ; Proto-Oncogene Proteins/genetics ; RNA Stability ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; Signal Transduction ; Ventricular Remodeling
Czasopismo naukowe
Tytuł :
Poly(ADP-Ribose) Polymerase Activity and Coronary Artery Disease in Type 2 Diabetes Mellitus: An Observational and Bidirectional Mendelian Randomization Study.
Autorzy :
Cui NH; Zhengzhou Key Laboratory of Children's Infection and Immunity, Children's Hospital Affiliated to Zhengzhou University, Henan, China (N.-h.C., J.-m.Y.).
Yang JM; Zhengzhou Key Laboratory of Children's Infection and Immunity, Children's Hospital Affiliated to Zhengzhou University, Henan, China (N.-h.C., J.-m.Y.).
Liu X; Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Henan, China (X.L., X.-b.W.).
Wang XB; Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Henan, China (X.L., X.-b.W.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Oct; Vol. 40 (10), pp. 2516-2526. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronary Artery Disease/*enzymology
Coronary Stenosis/*enzymology
Diabetes Mellitus, Type 2/*enzymology
Leukocytes/*enzymology
Poly (ADP-Ribose) Polymerase-1/*blood
Poly(ADP-ribose) Polymerases/*blood
Aged ; China ; Coronary Artery Disease/blood ; Coronary Artery Disease/genetics ; Coronary Artery Disease/therapy ; Coronary Stenosis/blood ; Coronary Stenosis/genetics ; Coronary Stenosis/therapy ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Mendelian Randomization Analysis ; Middle Aged ; Percutaneous Coronary Intervention/adverse effects ; Phenotype ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly(ADP-ribose) Polymerases/genetics ; Polymorphism, Single Nucleotide ; Prospective Studies ; Risk Assessment ; Risk Factors ; THP-1 Cells ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1'-phosphatase.
Autorzy :
Webb TE; University College London Hospital, 235 Euston Rd, Bloomsbury, London, NW 2BU, United Kingdom. Electronic address: .
Saad R; Royal Sussex County Hospital, Barry Building, Eastern Rd, Brighton, BN2 5BE, United Kingdom.
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Źródło :
Immunology letters [Immunol Lett] 2020 Aug; Vol. 224, pp. 38-39. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji :
Letter
MeSH Terms :
Betacoronavirus/*enzymology
Coronavirus Infections/*virology
Pneumonia, Viral/*virology
Poly(ADP-ribose) Polymerases/*metabolism
Pyrophosphatases/*metabolism
Viral Proteins/*metabolism
Amino Acid Sequence ; Animals ; Betacoronavirus/genetics ; COVID-19 ; Coronavirus Infections/enzymology ; Coronavirus Infections/immunology ; Host-Pathogen Interactions ; Humans ; Macrophage Activation ; Macrophages/enzymology ; Macrophages/immunology ; Macrophages/virology ; Pandemics ; Pneumonia, Viral/enzymology ; Pneumonia, Viral/immunology ; Poly(ADP-ribose) Polymerases/chemistry ; Poly(ADP-ribose) Polymerases/genetics ; Pyrophosphatases/chemistry ; Pyrophosphatases/genetics ; SARS-CoV-2 ; Sequence Homology ; T-Lymphocytes, Helper-Inducer/enzymology ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/virology ; Th1-Th2 Balance ; Viral Proteins/chemistry ; Viral Proteins/genetics
Opinia redakcyjna
Tytuł :
Regulation of poly ADP-ribosylation of VEGF by an interplay between PARP-16 and TNKS-2.
Autorzy :
Kunhiraman H; Department of Biochemistry and Molecular Biology, Central University of Kerala, Tejaswini Hills, Periya, Kasargod, Kerala, India.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, John Hopkins University, 1650 Orleans St., Baltimore, MD, 21231, USA.; Cancer and Blood Disorder Institute, Johns Hopkins All Children's Hospital, 600 5th St. South, St. Petersburg, FL, 33701, USA.
Ramachandran V; Department of Biochemistry and Molecular Biology, Central University of Kerala, Tejaswini Hills, Periya, Kasargod, Kerala, India.
Edatt L; Department of Biochemistry and Molecular Biology, Central University of Kerala, Tejaswini Hills, Periya, Kasargod, Kerala, India.
Sameer Kumar VB; Department of Biochemistry and Molecular Biology, Central University of Kerala, Tejaswini Hills, Periya, Kasargod, Kerala, India. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2020 Aug; Vol. 471 (1-2), pp. 15-27. Date of Electronic Publication: 2020 May 30.
Typ publikacji :
Journal Article
MeSH Terms :
Poly ADP Ribosylation*
Protein Processing, Post-Translational*
Poly(ADP-ribose) Polymerases/*metabolism
Tankyrases/*metabolism
Vascular Endothelial Growth Factor A/*metabolism
Animals ; Cells, Cultured ; Chick Embryo ; Humans ; Poly(ADP-ribose) Polymerases/genetics ; Tankyrases/genetics
Czasopismo naukowe
Tytuł :
Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR.
Autorzy :
Dhoonmoon A; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Schleicher EM; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Clements KE; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Nicolae CM; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Moldovan GL; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jul 27; Vol. 48 (13), pp. 7252-7264.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Replication*
Synthetic Lethal Mutations*
Poly(ADP-ribose) Polymerases/*metabolism
Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; CRISPR-Cas Systems ; Cell Line, Tumor ; Checkpoint Kinase 1/genetics ; Checkpoint Kinase 1/metabolism ; Humans ; Poly(ADP-ribose) Polymerases/genetics
Czasopismo naukowe

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