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Wyszukujesz frazę ""Poly \(ADP-Ribose\) Polymerase-1"" wg kryterium: Temat


Tytuł :
PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling.
Autorzy :
van Beek L; Structure and Biophysics, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
McClay É; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Garscube Campus, University of Glasgow, Glasgow G61 1QQ, UK.
Patel S; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
Schimpl M; Structure and Biophysics, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
Spagnolo L; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Garscube Campus, University of Glasgow, Glasgow G61 1QQ, UK.
Maia de Oliveira T; Structure and Biophysics, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 12; Vol. 22 (10). Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Cycle Proteins/*chemistry
Nucleosomes/*metabolism
Poly (ADP-Ribose) Polymerase-1/*chemistry
Poly(ADP-ribose) Polymerases/*chemistry
Allosteric Regulation/drug effects ; Carrier Proteins/metabolism ; Cell Cycle Proteins/metabolism ; DNA Repair ; Humans ; Models, Molecular ; Nuclear Proteins/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerases/metabolism ; Protein Domains/drug effects
Czasopismo naukowe
Tytuł :
NAM protects against cisplatin-induced acute kidney injury by suppressing the PARP1/p53 pathway.
Autorzy :
Wu W; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China.
Fu Y; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China.
Liu Z; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China.
Shu S; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China.
Wang Y; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China.
Tang C; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China.
Cai J; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China. Electronic address: .
Dong Z; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China; Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center, Augusta, GA, USA.. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 May 01; Vol. 418, pp. 115492. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cisplatin*
Acute Kidney Injury/*prevention & control
Kidney Tubules, Proximal/*drug effects
Niacinamide/*pharmacology
Poly (ADP-Ribose) Polymerase-1/*antagonists & inhibitors
Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology
Tumor Suppressor Protein p53/*metabolism
Acute Kidney Injury/chemically induced ; Acute Kidney Injury/enzymology ; Acute Kidney Injury/pathology ; Animals ; Apoptosis/drug effects ; Cell Line ; Disease Models, Animal ; Histones/metabolism ; Kidney Tubules, Proximal/enzymology ; Kidney Tubules, Proximal/pathology ; Male ; Mice, Inbred C57BL ; Phosphoproteins/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Rats ; Signal Transduction
Czasopismo naukowe
Tytuł :
Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
Autorzy :
Ogden TEH; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Yang JC; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Schimpl M; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Easton LE; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Underwood E; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Rawlins PB; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
McCauley MM; Department of Biochemistry & Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Langelier MF; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada.
Pascal JM; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada.
Embrey KJ; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Neuhaus D; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Feb 26; Vol. 49 (4), pp. 2266-2288.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Poly (ADP-Ribose) Polymerase-1/*chemistry
Allosteric Regulation ; Amides/chemistry ; Catalytic Domain ; Crystallography, X-Ray ; DNA Damage ; Enzyme Activation ; Models, Molecular ; Mutation ; Poly (ADP-Ribose) Polymerase-1/antagonists & inhibitors ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/chemistry ; Protein Domains
Czasopismo naukowe
Tytuł :
HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.
Autorzy :
Sun FH; Department of Biochemistry and Biophysics, Peking University Health Science Center, Beijing, China.; Department of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China.; Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Zhao P; Department of Biochemistry and Biophysics, Peking University Health Science Center, Beijing, China.; Department of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China.; Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Zhang N; School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.; Center for Precision Medicine Multi-omics Research, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Kong LL; Department of Biochemistry and Biophysics, Peking University Health Science Center, Beijing, China.; Department of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China.; Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Wong CCL; School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Yun CH; Department of Biochemistry and Biophysics, Peking University Health Science Center, Beijing, China. .; Department of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China. .; Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 15; Vol. 12 (1), pp. 1028. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carrier Proteins/*chemistry
DNA/*chemistry
Histones/*chemistry
Nuclear Proteins/*chemistry
Poly (ADP-Ribose) Polymerase-1/*chemistry
Serine/*metabolism
ADP-Ribosylation ; Amino Acid Sequence ; Animals ; Binding Sites ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cloning, Molecular ; Crystallography, X-Ray ; DNA/genetics ; DNA/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Glutamine/metabolism ; Histones/genetics ; Histones/metabolism ; Humans ; Mice ; Models, Molecular ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Static Electricity
Czasopismo naukowe
Tytuł :
Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases.
Autorzy :
Thapa K; Chitkara College of Pharmacy, Chitkara University, Punjab, India; Chitkara School of Pharmacy, Chitkara University, Himachal Pradesh, India.
Khan H; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Sharma U; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Grewal AK; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Singh TG; Chitkara College of Pharmacy, Chitkara University, Punjab, India. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 15; Vol. 267, pp. 118975. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neurodegenerative Diseases/*drug therapy
Neurodegenerative Diseases/*enzymology
Poly (ADP-Ribose) Polymerase-1/*metabolism
Animals ; Central Nervous System Diseases/drug therapy ; Central Nervous System Diseases/metabolism ; Humans ; Molecular Targeted Therapy ; Neurodegenerative Diseases/metabolism ; Poly (ADP-Ribose) Polymerase-1/antagonists & inhibitors ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Modulation of PARP activity by Monomethylarsonous (MMA ) acid and uranium in mouse thymus.
Autorzy :
Medina S; Department of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA; Department of Biology, New Mexico Highlands University, Las Vegas, NM, USA.
Zhou X; Department of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Lauer FT; Department of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Zhang H; Department of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Liu KJ; Department of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Lewis J; Department of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Burchiel SW; Department of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Jan 15; Vol. 411, pp. 115362. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Organometallic Compounds/*toxicity
Poly (ADP-Ribose) Polymerase-1/*antagonists & inhibitors
Poly(ADP-ribose) Polymerase Inhibitors/*toxicity
Thymus Gland/*drug effects
Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Oxidative Stress/drug effects ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Thymus Gland/enzymology
Czasopismo naukowe
Tytuł :
Uranium directly interacts with the DNA repair protein poly (ADP-ribose) polymerase 1.
Autorzy :
Zhou X; Department of Pharmaceutical Sciences, The University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Xue B; Department of Pharmaceutical Sciences, The University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Medina S; Department of Pharmaceutical Sciences, The University of New Mexico College of Pharmacy, Albuquerque, NM, USA; New Mexico Highlands University, Department of Biology, Las Vegas, NM 87701, United States.
Burchiel SW; Department of Pharmaceutical Sciences, The University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Liu KJ; Department of Pharmaceutical Sciences, The University of New Mexico College of Pharmacy, Albuquerque, NM, USA. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Jan 01; Vol. 410, pp. 115360. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair/*physiology
DNA Repair/*radiation effects
Poly (ADP-Ribose) Polymerase-1/*metabolism
Poly (ADP-Ribose) Polymerase-1/*radiation effects
Uranium/*metabolism
Uranium/*toxicity
Amino Acid Sequence ; Cells, Cultured ; Environmental Exposure/adverse effects ; Humans ; Infant, Newborn ; Keratinocytes/metabolism ; Keratinocytes/radiation effects ; Poly (ADP-Ribose) Polymerase-1/genetics ; Protein Binding/drug effects ; Protein Binding/physiology
Czasopismo naukowe
Tytuł :
Poly(ADP-Ribose) Polymerase 1 Promotes Inflammation and Fibrosis in a Mouse Model of Chronic Pancreatitis.
Autorzy :
El-Hamoly T; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; Drug Radiation Research Department, National Centre for Radiation Research and Technology, Atomic Energy Authority, 11787 Cairo, Egypt.
Hajnády Z; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; Doctoral School of Molecular Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Nagy-Pénzes M; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; Doctoral School of Molecular Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Bakondi E; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Regdon Z; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; Doctoral School of Molecular Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Demény MA; MTA-DE Cell Biology and Signaling Research Group, 4032 Debrecen, Hungary.
Kovács K; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; MTA-DE Cell Biology and Signaling Research Group, 4032 Debrecen, Hungary.
Hegedűs C; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Abd El-Rahman SS; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, 12211 Giza, Egypt.
Szabó É; Department of Dermatology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Maléth J; First Department of Medicine, University of Szeged, 6720 Szeged, Hungary.; HAS-USZ Momentum Epithel Cell Signalling and Secretion Research Group, 6720 Szeged, Hungary.; Department of Public Health, University of Szeged, 6720 Szeged, Hungary.
Hegyi P; János Szentágothai Research Centre, Institute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.; Momentum Gastroenterology Multidisciplinary Research Group, Hungarian Academy of Sciences, University of Szeged, 6720 Szeged, Hungary.
Virág L; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; MTA-DE Cell Biology and Signaling Research Group, 4032 Debrecen, Hungary.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 30; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Pancreatitis/*physiopathology
Poly (ADP-Ribose) Polymerase-1/*metabolism
Acinar Cells/metabolism ; Acute Disease ; Animals ; Ceruletide/pharmacology ; Disease Models, Animal ; Fibrosis ; Inflammation/pathology ; Interleukin-6/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Pancreas/metabolism ; Pancreatitis/immunology ; Pancreatitis, Chronic/pathology ; Poly (ADP-Ribose) Polymerase-1/physiology ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerases/metabolism ; Transforming Growth Factor beta/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm.
Autorzy :
Jeong KY; Research Center, MetiMedi Pharmaceuticals Co., Incheon 22006, Korea.
Park MH; Research Center, MetiMedi Pharmaceuticals Co., Incheon 22006, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 29; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Pancreatic Neoplasms/*drug therapy
Poly (ADP-Ribose) Polymerase-1/*antagonists & inhibitors
Antineoplastic Agents/therapeutic use ; DNA Damage ; DNA Repair ; Humans ; Oxidative Stress ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
CARM1 regulates replication fork speed and stress response by stimulating PARP1.
Autorzy :
Genois MM; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
Gagné JP; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec City, QC G1V 0A6, Canada; CHU de Québec Research Center, CHUL Pavilion, Oncology Axis, Québec City, Québec G1V 4G2, Canada.
Yasuhara T; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
Jackson J; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Saxena S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
Langelier MF; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Ahel I; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Bedford MT; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA.
Pascal JM; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Vindigni A; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Poirier GG; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec City, QC G1V 0A6, Canada; CHU de Québec Research Center, CHUL Pavilion, Oncology Axis, Québec City, Québec G1V 4G2, Canada.
Zou L; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 18; Vol. 81 (4), pp. 784-800.e8. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Single-Stranded*
DNA Replication*
Poly (ADP-Ribose) Polymerase-1/*metabolism
Protein-Arginine N-Methyltransferases/*metabolism
Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Line, Tumor ; HEK293 Cells ; Humans ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Poly (ADP-Ribose) Polymerase-1/genetics ; Protein-Arginine N-Methyltransferases/genetics ; RecQ Helicases/genetics ; RecQ Helicases/metabolism
Czasopismo naukowe
Tytuł :
Kaposi's sarcoma-associated herpesvirus processivity factor (PF-8) recruits cellular E3 ubiquitin ligase CHFR to promote PARP1 degradation and lytic replication.
Autorzy :
Chung WC; Virus-Host Interactions Laboratory, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.
Lee S; Virus-Host Interactions Laboratory, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.
Kim Y; Virus-Host Interactions Laboratory, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.
Seo JB; Metabolome Analysis Team, Korea Basic Science Institute, Seoul, Republic of Korea.
Song MJ; Virus-Host Interactions Laboratory, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.
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Źródło :
PLoS pathogens [PLoS Pathog] 2021 Jan 28; Vol. 17 (1), pp. e1009261. Date of Electronic Publication: 2021 Jan 28 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*metabolism
Herpesvirus 8, Human/*genetics
Immediate-Early Proteins/*metabolism
Neoplasm Proteins/*metabolism
Poly (ADP-Ribose) Polymerase-1/*metabolism
Poly-ADP-Ribose Binding Proteins/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Trans-Activators/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Viral Proteins/*metabolism
Cell Cycle Proteins/genetics ; Dimerization ; Down-Regulation ; Herpesvirus 8, Human/physiology ; Humans ; Immediate-Early Proteins/genetics ; Neoplasm Proteins/genetics ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly-ADP-Ribose Binding Proteins/genetics ; Protein Domains ; Proteolysis ; Trans-Activators/genetics ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/genetics ; Viral Proteins/genetics ; Virus Replication
Czasopismo naukowe
Tytuł :
Protective effects of PARP1-inhibitory compound in dry age-related macular degeneration.
Autorzy :
Ho J; Department of Biological Sciences, Chungnam National University, Daejeon, South Korea.
Jang KH; Department of Biological Sciences, Chungnam National University, Daejeon, South Korea.
Koo TS; Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon, South Korea.
Park C; Kukjepharma R&D Center, Sanseong-ro 47, Ansan, Gyeonggi-do, South Korea.
Kim YH; Kukjepharma R&D Center, Sanseong-ro 47, Ansan, Gyeonggi-do, South Korea.
Lee J; Kukjepharma R&D Center, Sanseong-ro 47, Ansan, Gyeonggi-do, South Korea.
Kim E; Department of Biological Sciences, Chungnam National University, Daejeon, South Korea. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jan; Vol. 133, pp. 111041. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article
MeSH Terms :
Macular Degeneration/*drug therapy
Poly (ADP-Ribose) Polymerase-1/*antagonists & inhibitors
Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology
Retinal Pigment Epithelium/*drug effects
Administration, Ophthalmic ; Animals ; Antioxidants/pharmacology ; Cell Line ; Disease Models, Animal ; Humans ; Iodates ; Macular Degeneration/chemically induced ; Macular Degeneration/enzymology ; Macular Degeneration/pathology ; Male ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Ocular Absorption ; Ophthalmic Solutions ; Oxidative Stress/drug effects ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/administration & dosage ; Rabbits ; Rats, Sprague-Dawley ; Retinal Pigment Epithelium/enzymology ; Retinal Pigment Epithelium/pathology
Czasopismo naukowe
Tytuł :
Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila.
Autorzy :
Bordet G; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, Stop 9061, Grand Forks, ND, 58202, USA.
Lodhi N; Fox Chase Cancer Center, Philadelphia, PA, USA.
Guo D; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, Stop 9061, Grand Forks, ND, 58202, USA.
Kossenkov A; The Wistar Institute, Philadelphia, PA, USA.
Tulin AV; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, Stop 9061, Grand Forks, ND, 58202, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Dec 03; Vol. 10 (1), pp. 21151. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation*
Genome, Insect*
Drosophila Proteins/*metabolism
Drosophila melanogaster/*enzymology
Drosophila melanogaster/*genetics
Poly (ADP-Ribose) Polymerase-1/*metabolism
Animals ; Cytochrome P-450 Enzyme System/metabolism ; Down-Regulation/genetics ; Drosophila Proteins/deficiency ; Drosophila Proteins/genetics ; Gene Expression Profiling ; Interspersed Repetitive Sequences/genetics ; Larva/genetics ; Poly (ADP-Ribose) Polymerase-1/deficiency ; Poly (ADP-Ribose) Polymerase-1/genetics ; Transcription Factors/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models.
Autorzy :
Frederick BA; Department of Radiation Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Colorado.; SuviCa, Inc., Boulder, Colorado.
Gupta R; Department of Radiation Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Atilano-Roque A; Department of Radiation Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Su TT; Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Colorado.; SuviCa, Inc., Boulder, Colorado.
Raben D; Department of Radiation Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
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Źródło :
Radiation research [Radiat Res] 2020 Nov 10; Vol. 194 (5), pp. 519-531.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Chemotherapy, Adjuvant*
Cetuximab/*pharmacology
DNA Repair/*drug effects
Head and Neck Neoplasms/*radiotherapy
Neoplasm Proteins/*antagonists & inhibitors
Phthalazines/*pharmacology
Piperazines/*pharmacology
Poly (ADP-Ribose) Polymerase-1/*antagonists & inhibitors
Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology
Squamous Cell Carcinoma of Head and Neck/*radiotherapy
Animals ; Apoptosis/drug effects ; Apoptosis/radiation effects ; Cell Line, Tumor ; Cetuximab/administration & dosage ; Cetuximab/therapeutic use ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Clone Cells ; Combined Modality Therapy ; DNA End-Joining Repair ; DNA, Neoplasm/drug effects ; DNA, Neoplasm/radiation effects ; Drug Synergism ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; ErbB Receptors/physiology ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/radiation effects ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/pathology ; Humans ; Mice ; Mice, Nude ; Neoplasm Proteins/genetics ; Neoplasm Proteins/physiology ; Phthalazines/administration & dosage ; Phthalazines/therapeutic use ; Piperazines/administration & dosage ; Piperazines/therapeutic use ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly (ADP-Ribose) Polymerase-1/physiology ; Poly(ADP-ribose) Polymerase Inhibitors/administration & dosage ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Proof of Concept Study ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/pathology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Sustained inhibition of PARP-1 activity delays glioblastoma recurrence by enhancing radiation-induced senescence.
Autorzy :
Ghorai A; Shilpee Dutt Laboratory, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India.
Mahaddalkar T; Shilpee Dutt Laboratory, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, 400085, India.
Thorat R; Laboratory Animal Facility, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India.
Dutt S; Shilpee Dutt Laboratory, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, 400085, India. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Oct 10; Vol. 490, pp. 44-53. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*pathology
Glioblastoma/*pathology
Neoplasm Recurrence, Local/*enzymology
Poly (ADP-Ribose) Polymerase-1/*metabolism
Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology
Animals ; Brain Neoplasms/enzymology ; Cellular Senescence/drug effects ; Cellular Senescence/radiation effects ; Glioblastoma/enzymology ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Recurrence, Local/pathology ; Phthalazines/pharmacology ; Piperazines/pharmacology ; Poly (ADP-Ribose) Polymerase-1/drug effects ; Poly (ADP-Ribose) Polymerase-1/radiation effects ; Radiation Tolerance/drug effects ; Radiotherapy ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
PARP1 catalytic variants reveal branching and chain length-specific functions of poly(ADP-ribose) in cellular physiology and stress response.
Autorzy :
Aberle L; Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Krüger A; Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Reber JM; Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Lippmann M; Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Hufnagel M; Department of Food Chemistry and Toxicology, Institute for Applied Biosciences, Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe, Germany.
Schmalz M; Department of Physics, University of Konstanz, 78457 Konstanz, Germany.
Trussina IREA; Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Schlesiger S; Department of Chemistry, University of Konstanz, 78457 Konstanz, Germany.
Zubel T; Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Schütz K; Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Marx A; Department of Chemistry, University of Konstanz, 78457 Konstanz, Germany.
Hartwig A; Department of Food Chemistry and Toxicology, Institute for Applied Biosciences, Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe, Germany.
Ferrando-May E; Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Bürkle A; Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Mangerich A; Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10015-10033.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Poly (ADP-Ribose) Polymerase-1*/chemistry
Poly (ADP-Ribose) Polymerase-1*/physiology
Poly Adenosine Diphosphate Ribose*/chemistry
Poly Adenosine Diphosphate Ribose*/physiology
Animals ; Cell Physiological Phenomena ; HeLa Cells ; Humans ; Mice ; Poly ADP Ribosylation
Czasopismo naukowe
Tytuł :
PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability.
Autorzy :
Martín-Guerrero SM; Departamento de Biología Celular, Facultad de Ciencias, Universidad de Granada, Spain.
Casado P; Signalling and Proteomics Group, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, U.K.
Hijazi M; Signalling and Proteomics Group, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, U.K.
Rajeeve V; Signalling and Proteomics Group, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, U.K.
Plaza-Díaz J; Departamento de Bioquímica y Biología Molecular II, Facultad de Farmacia, Universidad de Granada, Granada, Spain.; Department of Pediatrics, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.
Abadía-Molina F; Departamento de Biología Celular, Facultad de Ciencias, Universidad de Granada, Spain.; Instituto de Nutrición y Tecnología de los Alimentos 'José Mataix', Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain.
Navascués J; Departamento de Biología Celular, Facultad de Ciencias, Universidad de Granada, Spain.
Cuadros MA; Departamento de Biología Celular, Facultad de Ciencias, Universidad de Granada, Spain.
Cutillas PR; Signalling and Proteomics Group, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, U.K.
Martín-Oliva D; Departamento de Biología Celular, Facultad de Ciencias, Universidad de Granada, Spain.
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Źródło :
The Biochemical journal [Biochem J] 2020 Dec 11; Vol. 477 (23), pp. 4491-4513.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oxidative Stress*
Adaptor Proteins, Signal Transducing/*metabolism
Poly (ADP-Ribose) Polymerase-1/*metabolism
Transcription Factors/*metabolism
AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; HeLa Cells ; Humans ; Hydrogen Peroxide/pharmacology ; NAD/genetics ; NAD/metabolism ; Phosphorylation/drug effects ; Phosphorylation/genetics ; Poly (ADP-Ribose) Polymerase-1/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Association of PARP1-specific polymorphisms and haplotypes with non-small cell lung cancer subtypes.
Autorzy :
Jin J; Department of Epidemiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
Robeson H; Department of Epidemiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
Fagan P; Department of Health Behavior and Health Education, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.; Center for the Studies of Tobacco, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
Orloff MS; Department of Epidemiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.; Center for the Studies of Tobacco, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Dec 07; Vol. 15 (12), pp. e0243509. Date of Electronic Publication: 2020 Dec 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*genetics
Haplotypes/*genetics
Poly (ADP-Ribose) Polymerase-1/*genetics
Adult ; Aged ; Aged, 80 and over ; Alleles ; Carcinoma, Non-Small-Cell Lung/classification ; Case-Control Studies ; Female ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Linkage Disequilibrium/genetics ; Lung Neoplasms/genetics ; Male ; Middle Aged ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Polymorphism, Single Nucleotide/genetics ; Prognosis
Czasopismo naukowe
Tytuł :
A DNA-encoded library for the identification of natural product binders that modulate poly (ADP-ribose) polymerase 1, a validated anti-cancer target.
Autorzy :
Li J; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China; Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031, Shanghai, China; University of Chinese Academy of Sciences, 100049, Beijing, China.
Li Y; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China; Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031, Shanghai, China; University of Chinese Academy of Sciences, 100049, Beijing, China.
Lu F; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.
Liu L; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.
Ji Q; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.
Song K; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.
Yin Q; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.
Lerner RA; Department of Chemistry, Scripps Research Institute, La Jolla, CA, 92037, USA.
Yang G; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China.
Xu H; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China. Electronic address: .
Ma P; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 03; Vol. 533 (2), pp. 241-248. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA/*chemistry
Poly (ADP-Ribose) Polymerase-1/*metabolism
Poly(ADP-ribose) Polymerase Inhibitors/*chemistry
Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Biological Products/chemical synthesis ; Biological Products/chemistry ; Biological Products/pharmacology ; Cell Line, Tumor ; DNA/chemical synthesis ; Drug Discovery ; Drug Evaluation, Preclinical ; Humans ; Luteolin/chemical synthesis ; Luteolin/chemistry ; Luteolin/pharmacology ; Poly (ADP-Ribose) Polymerase-1/antagonists & inhibitors ; Poly(ADP-ribose) Polymerase Inhibitors/chemical synthesis ; Protein Binding ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Surface Plasmon Resonance
Czasopismo naukowe
Tytuł :
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.
Autorzy :
Visnes T; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.; Department of Biotechnology and Nanomedicine, SINTEF Industry, N-7465 Trondheim,Norway.
Benítez-Buelga C; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Cázares-Körner A; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Sanjiv K; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Hanna BMF; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Mortusewicz O; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Rajagopal V; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Albers JJ; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Hagey DW; Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Bekkhus T; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Eshtad S; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Baquero JM; Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Masuyer G; Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden.; Department of Pharmacy and Pharmacology, Centre for Therapeutic Innovation. University of Bath, Bath BA2 7AY, UK.
Wallner O; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Müller S; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Pham T; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Göktürk C; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Rasti A; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Suman S; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Torres-Ruiz R; Molecular Cytogenetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, 28029, Spain.; Josep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona 08036, Spain.
Sarno A; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; The Liaison Committee for Education, Research and Innovation in Central Norway, Trondheim, Norway.; Department of Environment and New Resources, SINTEF Ocean, N-7010 Trondheim, Norway.
Wiita E; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Homan EJ; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Karsten S; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Marimuthu K; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Michel M; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Koolmeister T; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Scobie M; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Loseva O; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Almlöf I; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Unterlass JE; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Pettke A; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Boström J; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.; Science for Life Laboratory, Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Pandey M; Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK.
Gad H; Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK.
Herr P; Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK.
Jemth AS; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
El Andaloussi S; Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Kalderén C; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Rodriguez-Perales S; Molecular Cytogenetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, 28029, Spain.
Benítez J; Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Spanish Network on Rare Diseases (CIBERER), Madrid, Spain.
Krokan HE; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; The Liaison Committee for Education, Research and Innovation in Central Norway, Trondheim, Norway.
Altun M; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.; Science for Life Laboratory, Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden.; Department of Experimental Medical Science, Lund University, SE-221 00 Lund, Sweden.
Berglund UW; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Helleday T; Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.; Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 02; Vol. 48 (21), pp. 12234-12251.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Colonic Neoplasms/*drug therapy
DNA Glycosylases/*genetics
DNA, Neoplasm/*genetics
Poly (ADP-Ribose) Polymerase-1/*immunology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/mortality ; DNA Damage ; DNA Glycosylases/antagonists & inhibitors ; DNA Glycosylases/metabolism ; DNA Repair/drug effects ; DNA Replication/drug effects ; DNA, Neoplasm/metabolism ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/pharmacology ; Guanine/analogs & derivatives ; Guanine/metabolism ; HCT116 Cells ; Humans ; Mice ; Mice, Nude ; Molecular Targeted Therapy ; Oxidative Stress ; Poly (ADP-Ribose) Polymerase-1/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Reactive Oxygen Species/antagonists & inhibitors ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Survival Analysis ; Tumor Burden/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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