Temat: "Poly ADP-ribosylation" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: High-throughput screening assay for PARP-HPF1 interaction inhibitors to affect DNA damage repair.
Autorzy:: Dhakar SS; Faculty of Biochemistry and Molecular Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland.
Galera-Prat A; Faculty of Biochemistry and Molecular Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland.
Lehtiö L; Faculty of Biochemistry and Molecular Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Feb 16; Vol. 14 (1), pp. 3875. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Histones*/drug effects
Histones*/metabolism
Poly(ADP-ribose) Polymerase Inhibitors*/chemistry
Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology
DNA Damage ; DNA Repair ; High-Throughput Screening Assays ; Poly (ADP-Ribose) Polymerase-1/antagonists & inhibitors ; Poly ADP Ribosylation

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Skocz do pozycji: 2.

Tytuł:: Poly(ADP-ribose)-binding protein RCD1 is a plant PARylation reader regulated by Photoregulatory Protein Kinases.
Autorzy:: Vainonen JP; Organismal and Evolutionary Biology Research Programme, Faculty of Biological and Environmental Sciences, and Viikki Plant Science Center, University of Helsinki, FI-00014, Helsinki, Finland.
Gossens R; Organismal and Evolutionary Biology Research Programme, Faculty of Biological and Environmental Sciences, and Viikki Plant Science Center, University of Helsinki, FI-00014, Helsinki, Finland.
Krasensky-Wrzaczek J; Organismal and Evolutionary Biology Research Programme, Faculty of Biological and Environmental Sciences, and Viikki Plant Science Center, University of Helsinki, FI-00014, Helsinki, Finland.; Institute of Plant Molecular Biology, Biology Centre, Czech Academy of Sciences, Branišovská1160/31, 370 05, České Budějovice, Czech Republic.
De Masi R; Department Biochemistry of Plant Interactions, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany.; Dahlem Centre of Plant Sciences, Institute of Biology, Freie Universität Berlin, Königin-Luise-Str. 12-16, 14195, Berlin, Germany.
Danciu I; Gregor Mendel Institute, Austrian Academy of Sciences, Vienna BioCenter, Dr. Bohr-Gasse 3, 1030, Vienna, Austria.; Bioresources Unit, Center for Health & Bioresources, AIT Austrian Institute of Technology GmbH, Konrad Lorenz Straße 24, 3430, Tulln, Austria.
Puukko T; Organismal and Evolutionary Biology Research Programme, Faculty of Biological and Environmental Sciences, and Viikki Plant Science Center, University of Helsinki, FI-00014, Helsinki, Finland.
Battchikova N; Department of Biochemistry, Molecular Plant Biology, University of Turku, FI-20014, Turku, Finland.
Jonak C; Gregor Mendel Institute, Austrian Academy of Sciences, Vienna BioCenter, Dr. Bohr-Gasse 3, 1030, Vienna, Austria.; Bioresources Unit, Center for Health & Bioresources, AIT Austrian Institute of Technology GmbH, Konrad Lorenz Straße 24, 3430, Tulln, Austria.
Wirthmueller L; Department Biochemistry of Plant Interactions, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany.; Dahlem Centre of Plant Sciences, Institute of Biology, Freie Universität Berlin, Königin-Luise-Str. 12-16, 14195, Berlin, Germany.
Wrzaczek M; Organismal and Evolutionary Biology Research Programme, Faculty of Biological and Environmental Sciences, and Viikki Plant Science Center, University of Helsinki, FI-00014, Helsinki, Finland.; Institute of Plant Molecular Biology, Biology Centre, Czech Academy of Sciences, Branišovská1160/31, 370 05, České Budějovice, Czech Republic.
Shapiguzov A; Organismal and Evolutionary Biology Research Programme, Faculty of Biological and Environmental Sciences, and Viikki Plant Science Center, University of Helsinki, FI-00014, Helsinki, Finland.; Natural Resources Institute Finland (Luke), Production Systems, Toivonlinnantie 518, FI-21500, Piikkiö, Finland.
Kangasjärvi J; Organismal and Evolutionary Biology Research Programme, Faculty of Biological and Environmental Sciences, and Viikki Plant Science Center, University of Helsinki, FI-00014, Helsinki, Finland. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2023 Apr 19; Vol. 6 (1), pp. 429. Date of Electronic Publication: 2023 Apr 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Poly Adenosine Diphosphate Ribose*/metabolism
Poly ADP Ribosylation*
Protein Kinases/genetics ; Protein Kinases/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Gene Expression Regulation

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Skocz do pozycji: 3.

Tytuł:: Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly(ADP-ribosyl)ation, calpains and autophagy.
Autorzy:: Wang J; School of Medicine, The Stanley Scott Cancer Center/Louisiana Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Ghonim MA; School of Medicine, The Stanley Scott Cancer Center/Louisiana Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.; Department of Microbiology and Immunology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Ibba SV; School of Medicine, The Stanley Scott Cancer Center/Louisiana Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Luu HH; School of Medicine, The Stanley Scott Cancer Center/Louisiana Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Aydin Y; Department of Pathology and Laboratory Sciences, Tulane University Health Science Center, New Orleans, USA.
Greer PA; Division of Cancer Biology and Genetics, Cancer Research Institute, Kingston, ON, Canada.
Boulares AH; School of Medicine, The Stanley Scott Cancer Center/Louisiana Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA. .; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2022 Nov 08; Vol. 20 (1), pp. 521. Date of Electronic Publication: 2022 Nov 08.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Poly ADP Ribosylation*
Poly(ADP-ribose) Polymerases*/metabolism
Humans ; Mice ; Animals ; Calpain/genetics ; Calpain/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors ; Interleukin-4/pharmacology ; Interleukin-4/metabolism ; Autophagy ; Inflammation ; STAT6 Transcription Factor/metabolism

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Skocz do pozycji: 4.

Tytuł:: TBM Hunter: Identify and Score Canonical, Extended, and Unconventional Tankyrase-Binding Motifs in Any Protein.
Autorzy:: Clements CM; Department of Dermatology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Shellman SX; Department of Computer Science, University of Colorado Boulder, Boulder, CO 80309, USA.
Shellman MH; H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Shellman YG; Department of Dermatology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Charles C. Gates Regenerative Medicine and Stem Cell Biology Institute, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 30; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 30.
Typ publikacji:: Review; Journal Article
MeSH Terms:: Tankyrases*/metabolism
Ankyrin Repeat ; Poly ADP Ribosylation

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Skocz do pozycji: 5.

Tytuł:: A Double-Edged Sword: The Two Faces of PARylation.
Autorzy:: Kang M; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si 58245, Korea.
Park S; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si 58245, Korea.
Park SH; Genetic and Epigenetic Toxicology Research Group, Korea Institute of Toxicology, Daejeon 34141, Korea.
Lee HG; Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
Park JH; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si 58245, Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Aug 29; Vol. 23 (17). Date of Electronic Publication: 2022 Aug 29.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Poly ADP Ribosylation*/genetics
Poly(ADP-ribose) Polymerases*/genetics
Poly(ADP-ribose) Polymerases*/metabolism
DNA Repair ; Humans ; Inflammation ; Poly(ADP-ribose) Polymerase Inhibitors

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Skocz do pozycji: 6.

Tytuł:: Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage.
Autorzy:: Liu HY; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Liu YY; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.; Cancer Institute, Shanghai Medical College, Fudan University, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.; Department of Breast Surgery, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Zhang YL; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.; Cancer Institute, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Ning Y; Department of Pathology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200032, China. .
Zhang FL; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. .; Cancer Institute, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .
Li DQ; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. .; Cancer Institute, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .; Department of Breast Surgery, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .; Shanghai Key Laboratory of Breast Cancer, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .; Shanghai Key Laboratory of Radiation Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .; Pokaż więcej
Źródło:: Cell communication and signaling : CCS [Cell Commun Signal] 2022 Aug 19; Vol. 20 (1), pp. 127. Date of Electronic Publication: 2022 Aug 19.
Typ publikacji:: Journal Article; Video-Audio Media; Research Support, Non-U.S. Gov't
MeSH Terms:: Acetyltransferases*
Poly ADP Ribosylation*
Cell Nucleus ; DNA Damage ; Humans ; Lysine ; N-Terminal Acetyltransferases ; Poly (ADP-Ribose) Polymerase-1/genetics ; Transcription Factors

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Skocz do pozycji: 7.

Tytuł:: TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation.
Autorzy:: Tolić A; Department of Molecular Biology, Institute for Biological Research 'Siniša Stanković', National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia.
Ravichandran M; Institute of Biochemistry, University of Stuttgart, Pfaffenwaldring 55, 70569, Stuttgart, Germany.; Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue, HSW 1301, San Francisco, CA, 94143, USA.
Rajić J; Department of Molecular Biology, Institute for Biological Research 'Siniša Stanković', National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia.
Đorđević M; Department of Molecular Biology, Institute for Biological Research 'Siniša Stanković', National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia.
Đorđević M; Department of Molecular Biology, Institute for Biological Research 'Siniša Stanković', National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia.
Dinić S; Department of Molecular Biology, Institute for Biological Research 'Siniša Stanković', National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia.
Grdović N; Department of Molecular Biology, Institute for Biological Research 'Siniša Stanković', National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia.
Jovanović JA; Department of Molecular Biology, Institute for Biological Research 'Siniša Stanković', National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia.
Mihailović M; Department of Molecular Biology, Institute for Biological Research 'Siniša Stanković', National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia.
Nestorović N; Department of Cytology, Institute for Biological Research 'Siniša Stanković', National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia.
Jurkowski TP; Institute of Biochemistry, University of Stuttgart, Pfaffenwaldring 55, 70569, Stuttgart, Germany. .; School of Biosciences, Cardiff University, Cardiff, Wales, Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK. .
Uskoković AS; Department of Molecular Biology, Institute for Biological Research 'Siniša Stanković', National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia. .
Vidaković MS; Department of Molecular Biology, Institute for Biological Research 'Siniša Stanković', National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia. .; Pokaż więcej
Źródło:: Epigenetics & chromatin [Epigenetics Chromatin] 2022 Apr 05; Vol. 15 (1), pp. 11. Date of Electronic Publication: 2022 Apr 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Poly ADP Ribosylation*
Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology
DNA/metabolism ; DNA Methylation ; DNA Repair

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Skocz do pozycji: 8.

Tytuł:: PARP1 is activated by membrane damage and is involved in membrane repair through poly(ADP-ribosyl)ation.
Autorzy:: Mashimo M; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe, Japan.
Kita M; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe, Japan.
Nobeyama A; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe, Japan.
Nomura A; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe, Japan.
Fujii T; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe, Japan.; Pokaż więcej
Źródło:: Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2022 Apr; Vol. 27 (4), pp. 305-312. Date of Electronic Publication: 2022 Feb 21.
Typ publikacji:: Journal Article
MeSH Terms:: Poly (ADP-Ribose) Polymerase-1*/genetics
Poly (ADP-Ribose) Polymerase-1*/metabolism
Poly ADP Ribosylation*
Poly Adenosine Diphosphate Ribose*/metabolism
HEK293 Cells ; HeLa Cells ; Humans ; Poly(ADP-ribose) Polymerases/chemistry ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/metabolism

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Skocz do pozycji: 9.

Tytuł:: Role of YB-1 in Regulation of Poly(ADP-Ribosylation) Catalyzed by Poly(ADP-Ribose) Polymerases.
Autorzy:: Alemasova EE; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Naumenko KN; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Sukhanova MV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Lavrik OI; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia. .; Novosibirsk State University, Novosibirsk, 630090, Russia.; Pokaż więcej
Źródło:: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2022 Jan; Vol. 87 (Suppl 1), pp. S32-S0.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Poly ADP Ribosylation*
Poly(ADP-ribose) Polymerases*/metabolism
Catalysis ; DNA Damage ; Poly Adenosine Diphosphate Ribose ; Proteins/metabolism

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Skocz do pozycji: 10.

Tytuł:: LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation.
Autorzy:: Shi F; Department of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.
Wu L; Department of Urology, Shanghai General Hospital, Nanjing Medical University, Shanghai, 200080, China.
Cui D; Department of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.; Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China.
Sun M; Department of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.
Shen Y; School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
Zhou Z; Department of Urology, Shanghai General Hospital, Nanjing Medical University, Shanghai, 200080, China.
Deng Z; Department of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.
Han B; Department of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.; Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China.
Xia S; Department of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.; Department of Urology, Shanghai General Hospital, Nanjing Medical University, Shanghai, 200080, China.; Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China.
Zhu Z; Department of Internal Medicine, Division of Hematology/Oncology, University of California Davis, Sacramento, CA, 95817, USA. .
Sun F; Department of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China. .; Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China. .; Pokaż więcej
Źródło:: Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2023 Jun; Vol. 46 (3), pp. 761-776. Date of Electronic Publication: 2023 Mar 13.
Typ publikacji:: Journal Article
MeSH Terms:: Prostatic Neoplasms, Castration-Resistant*/pathology
RNA, Long Noncoding*/genetics
Humans ; Male ; Animals ; Mice ; NAD/metabolism ; Poly ADP Ribosylation ; Mice, Inbred NOD ; Mice, SCID ; Poly (ADP-Ribose) Polymerase-1/genetics

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Skocz do pozycji: 11.

Tytuł:: PARP2 poly(ADP-ribosyl)ates nuclear factor erythroid 2-related factor 2 (NRF2) affecting NRF2 subcellular localization.
Autorzy:: Jankó L; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Egyetem Tér 1., 4032, Debrecen, Hungary.; Center of Excellence, The Hungarian Academy of Sciences, Budapest, Hungary.
Tóth E; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Egyetem Tér 1., 4032, Debrecen, Hungary.; Center of Excellence, The Hungarian Academy of Sciences, Budapest, Hungary.
Laczik M; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary.
Rauch B; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Egyetem Tér 1., 4032, Debrecen, Hungary.; Center of Excellence, The Hungarian Academy of Sciences, Budapest, Hungary.
Janka E; Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary.
Bálint BL; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary.; Department of Bioinformatics, Semmelweis University, Tűzoltó Utca 7-9., Budapest, 1094, Hungary.
Bai P; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Egyetem Tér 1., 4032, Debrecen, Hungary. .; Center of Excellence, The Hungarian Academy of Sciences, Budapest, Hungary. .; MTA-DE Lendület Laboratory of Cellular Metabolism, Debrecen, 4032, Hungary. .; Research Center for Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary. .; MTA-DE Cell Biology and Signaling Research Group ELKH, Debrecen, Hungary. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 May 15; Vol. 13 (1), pp. 7869. Date of Electronic Publication: 2023 May 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antioxidants*
NF-E2-Related Factor 2*/genetics
Cell Nucleus ; DNA Repair ; Poly ADP Ribosylation ; Animals ; Mice

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Skocz do pozycji: 12.

Tytuł:: The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context.
Autorzy:: Kutuzov MM; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.
Belousova EA; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.
Kurgina TA; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.; Novosibirsk State University, Novosibirsk, Russia.
Ukraintsev AA; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.
Vasil'eva IA; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.
Khodyreva SN; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.
Lavrik OI; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia. .; Novosibirsk State University, Novosibirsk, Russia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Mar 01; Vol. 11 (1), pp. 4849. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: DNA Repair*
Poly ADP Ribosylation*
DNA/*chemistry
Nucleosomes/*chemistry
Poly (ADP-Ribose) Polymerase-1/*chemistry
Poly(ADP-ribose) Polymerases/*chemistry
DNA/metabolism ; Humans ; Nucleosomes/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly(ADP-ribose) Polymerases/metabolism

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Skocz do pozycji: 13.

Tytuł:: NAMPT and PARylation Are Involved in the Pathogenesis of Atopic Dermatitis.
Autorzy:: Arroyo AB; Inmunidad, Inflamación y Cáncer, Departamento de Biología Celular e Histología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.; Instituto Murciano de Investigación Biosanitaria (IMIB)-Pascual Parrilla, 30120 Murcia, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Bernal-Carrión M; Inmunidad, Inflamación y Cáncer, Departamento de Biología Celular e Histología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.; Instituto Murciano de Investigación Biosanitaria (IMIB)-Pascual Parrilla, 30120 Murcia, Spain.
Cantón-Sandoval J; Inmunidad, Inflamación y Cáncer, Departamento de Biología Celular e Histología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.; Instituto Murciano de Investigación Biosanitaria (IMIB)-Pascual Parrilla, 30120 Murcia, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Cabas I; Inmunidad, Inflamación y Cáncer, Departamento de Biología Celular e Histología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.; Instituto Murciano de Investigación Biosanitaria (IMIB)-Pascual Parrilla, 30120 Murcia, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Corbalán-Vélez R; Instituto Murciano de Investigación Biosanitaria (IMIB)-Pascual Parrilla, 30120 Murcia, Spain.; Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.
Martínez-Menchón T; Instituto Murciano de Investigación Biosanitaria (IMIB)-Pascual Parrilla, 30120 Murcia, Spain.; Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.
Ferri B; Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.
Cayuela ML; Instituto Murciano de Investigación Biosanitaria (IMIB)-Pascual Parrilla, 30120 Murcia, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.
García-Moreno D; Instituto Murciano de Investigación Biosanitaria (IMIB)-Pascual Parrilla, 30120 Murcia, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Mulero V; Inmunidad, Inflamación y Cáncer, Departamento de Biología Celular e Histología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.; Instituto Murciano de Investigación Biosanitaria (IMIB)-Pascual Parrilla, 30120 Murcia, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Apr 28; Vol. 24 (9). Date of Electronic Publication: 2023 Apr 28.
Typ publikacji:: Journal Article
MeSH Terms:: Dermatitis, Atopic*
Psoriasis*/etiology
Animals ; Humans ; Inflammation ; NAD/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly Adenosine Diphosphate Ribose/metabolism ; Poly ADP Ribosylation ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Zebrafish/metabolism

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Skocz do pozycji: 14.

Tytuł:: A Multi-Endpoint Approach to Base Excision Repair Incision Activity Augmented by PARylation and DNA Damage Levels in Mice: Impact of Sex and Age.
Autorzy:: Winkelbeiner N; Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), 14558 Berlin-Potsdam-Jena-Wuppertal, Germany.
Wandt VK; Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), 14558 Berlin-Potsdam-Jena-Wuppertal, Germany.
Ebert F; Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), 14558 Berlin-Potsdam-Jena-Wuppertal, Germany.
Lossow K; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), 14558 Berlin-Potsdam-Jena-Wuppertal, Germany.; Department of Molecular Nutritional Physiology, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena, Germany.; German Institute of Human Nutrition, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Bankoglu EE; Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Straße 9, 97078 Würzburg, Germany.
Martin M; Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Mangerich A; Department of Biology, Molecular Toxicology Group, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany.
Stopper H; Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Straße 9, 97078 Würzburg, Germany.
Bornhorst J; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), 14558 Berlin-Potsdam-Jena-Wuppertal, Germany.; Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany.
Kipp AP; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), 14558 Berlin-Potsdam-Jena-Wuppertal, Germany.; Department of Molecular Nutritional Physiology, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena, Germany.
Schwerdtle T; Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), 14558 Berlin-Potsdam-Jena-Wuppertal, Germany.; German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Sep 09; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 09.
Typ publikacji:: Journal Article; Validation Study
MeSH Terms:: DNA Damage*
DNA Repair*
Poly ADP Ribosylation*
Aging/*metabolism
Oligonucleotides/*isolation & purification
Animals ; Denaturing Gradient Gel Electrophoresis ; Female ; Hep G2 Cells ; Humans ; Liver/metabolism ; Male ; Mice, Inbred C57BL ; Sex Characteristics

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Skocz do pozycji: 15.

Tytuł:: Extracellular NAD enhances PARP-dependent DNA repair capacity independently of CD73 activity.
Autorzy:: Wilk A; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36604, USA.
Hayat F; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36604, USA.
Cunningham R; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36604, USA.
Li J; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36604, USA.
Garavaglia S; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100, Novara, Italy.
Zamani L; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.
Ferraris DM; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100, Novara, Italy.
Sykora P; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.; Amelia Technologies, 14676 Rothgeb Drive, Rockville, MD, 20850, USA.
Andrews J; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.
Clark J; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36604, USA.
Davis A; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.
Chaloin L; Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, CNRS, 34293, Montpellier, France.
Rizzi M; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100, Novara, Italy.
Migaud M; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36604, USA.
Sobol RW; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA. .; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36604, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Jan 20; Vol. 10 (1), pp. 651. Date of Electronic Publication: 2020 Jan 20.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: DNA Damage*
DNA Repair*
Poly ADP Ribosylation*
5'-Nucleotidase/*metabolism
5'-Nucleotidase/*physiology
NAD/*metabolism
NAD/*physiology
Poly(ADP-ribose) Polymerases/*physiology
Tumor Microenvironment/*genetics
Tumor Microenvironment/*physiology
5'-Nucleotidase/genetics ; Gene Expression ; Gene Expression Regulation, Neoplastic ; Humans ; MCF-7 Cells ; Mitochondria/physiology ; Reactive Oxygen Species/metabolism ; Sirtuins ; X-ray Repair Cross Complementing Protein 1/metabolism

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Skocz do pozycji: 16.

Tytuł:: DNA‑PKcs PARylation regulates DNA‑PK kinase activity in the DNA damage response.
Autorzy:: Han Y; Institute for Environmental Medicine and Radiation Hygiene, School of Public Health, University of South China, Hengyang, Hunan 421001, P.R. China.
Jin F; Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R. China.
Xie Y; Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R. China.
Liu Y; Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R. China.
Hu S; Institute for Environmental Medicine and Radiation Hygiene, School of Public Health, University of South China, Hengyang, Hunan 421001, P.R. China.
Liu XD; Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R. China.
Guan H; Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R. China.
Gu Y; Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R. China.
Ma T; Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R. China.
Zhou PK; Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2019 Oct; Vol. 20 (4), pp. 3609-3616. Date of Electronic Publication: 2019 Sep 02.
Typ publikacji:: Journal Article
MeSH Terms:: DNA Damage*
Poly ADP Ribosylation*
DNA-Activated Protein Kinase/*metabolism
Neoplasms/*metabolism
DNA Repair ; HeLa Cells ; Humans ; Neoplasms/genetics ; Poly (ADP-Ribose) Polymerase-1/metabolism

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Skocz do pozycji: 17.

Tytuł:: Interactions of PARP1 Inhibitors with PARP1-Nucleosome Complexes.
Autorzy:: Maluchenko N; Biology Faculty, Lomonosov Moscow State University, 119234 Moscow, Russia.
Koshkina D; Biology Faculty, Lomonosov Moscow State University, 119234 Moscow, Russia.; Institute of Gene Biology RAS, 34/5 Vavilov Str., 119334 Moscow, Russia.
Korovina A; Biology Faculty, Lomonosov Moscow State University, 119234 Moscow, Russia.
Studitsky V; Biology Faculty, Lomonosov Moscow State University, 119234 Moscow, Russia.; Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Feofanov A; Biology Faculty, Lomonosov Moscow State University, 119234 Moscow, Russia.; Institute of Gene Biology RAS, 34/5 Vavilov Str., 119334 Moscow, Russia.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Oct 23; Vol. 11 (21). Date of Electronic Publication: 2022 Oct 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Nucleosomes*
Chromatin*
Poly ADP Ribosylation ; Histones/metabolism

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Skocz do pozycji: 18.

Tytuł:: Pharmacodynamic effects of the PARP inhibitor talazoparib (MDV3800, BMN 673) in patients with BRCA-mutated advanced solid tumors
Autorzy:: Mittra, ArjunAff1, Aff8
Coyne, Geraldine H. O’ Sullivan
Zlott, Jennifer
Kummar, ShivaaniAff1, Aff9
Meehan, Robert
Rubinstein, Lawrence
Juwara, Lamin
Wilsker, Deborah
Ji, Jiuping
Miller, Brandon
Navas, TonyAff4, Aff10
Ferry-Galow, Katherine V.
Voth, Andrea Regier
Chang, Ting-Chia
Jiwani, Shahanawaz
Parchment, Ralph E.
Doroshow, James H.Aff1, Aff7
Chen, Alice P.Aff1, IDs00280023046000_cor18; Pokaż więcej
Źródło:: Cancer Chemotherapy and Pharmacology. 93(3):177-189

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Szczegóły

Skocz do pozycji: 19.

Tytuł:: Tankyrase Regulates Neurite Outgrowth through Poly(ADP-ribosyl)ation-Dependent Activation of β-Catenin Signaling.
Autorzy:: Mashimo M; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe 610-0395, Japan.
Kita M; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe 610-0395, Japan.
Uno A; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe 610-0395, Japan.
Nii M; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe 610-0395, Japan.
Ishihara M; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe 610-0395, Japan.
Honda T; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Gotoh-Kinoshita Y; Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe 610-0395, Japan.
Nomura A; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe 610-0395, Japan.
Nakamura H; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Murayama T; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Kizu R; Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe 610-0395, Japan.
Fujii T; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe 610-0395, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Mar 04; Vol. 23 (5). Date of Electronic Publication: 2022 Mar 04.
Typ publikacji:: Journal Article
MeSH Terms:: Tankyrases*/metabolism
Animals ; Axin Protein/genetics ; Mammals/metabolism ; Neuronal Outgrowth ; Poly ADP Ribosylation ; Poly Adenosine Diphosphate Ribose/metabolism ; Rats ; Wnt Signaling Pathway ; beta Catenin/metabolism

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Skocz do pozycji: 20.

Tytuł:: Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.
Autorzy:: Kurgina TA; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.; Novosibirsk State University, Novosibirsk, Russia.
Moor NA; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.
Kutuzov MM; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.
Naumenko KN; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.
Ukraintsev AA; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.
Lavrik OI; Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia. .; Novosibirsk State University, Novosibirsk, Russia. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2021 Nov 03; Vol. 4 (1), pp. 1259. Date of Electronic Publication: 2021 Nov 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carrier Proteins/*genetics
Histones/*metabolism
Nuclear Proteins/*genetics
Nucleosomes/*metabolism
Poly (ADP-Ribose) Polymerase-1/*genetics
Poly(ADP-ribose) Polymerases/*genetics
Animals ; Carrier Proteins/metabolism ; Humans ; Mice ; Nuclear Proteins/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly ADP Ribosylation ; Poly(ADP-ribose) Polymerases/metabolism

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