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Tytuł :
Third-generation solid dispersion combining Soluplus and poloxamer 407 enhances the oral bioavailability of resveratrol.
Autorzy :
Vasconcelos T; BIAL-Portela & Cª, S.A., Avenida da Siderugia Nacional, 4745-457 Trofa, Portugal; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; INEB-Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal.
Prezotti F; Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas de Araraquara, Drugs and Pharmaceuticals, Brazil.
Araújo F; BIAL-Portela & Cª, S.A., Avenida da Siderugia Nacional, 4745-457 Trofa, Portugal.
Lopes C; BIAL-Portela & Cª, S.A., Avenida da Siderugia Nacional, 4745-457 Trofa, Portugal.
Loureiro A; BIAL-Portela & Cª, S.A., Avenida da Siderugia Nacional, 4745-457 Trofa, Portugal.
Marques S; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; CIBIO/InBIO-UP-Research Centre in Biodiversity and Genetic Resources, University of Porto, Rua Padre Armando Quintas, 7, 4485-661 Vairão, Portugal.
Sarmento B; INEB-Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde and Instituto Universitário de Ciências da Saúde, Rua Central de Gandra 1317, 4585-116, Gandra, Portugal. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 Feb 15; Vol. 595, pp. 120245. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants/*pharmacokinetics
Drug Compounding/*methods
Poloxamer/*chemistry
Polyethylene Glycols/*chemistry
Polyvinyls/*chemistry
Resveratrol/*pharmacokinetics
Administration, Oral ; Animals ; Antioxidants/administration & dosage ; Antioxidants/chemistry ; Biological Availability ; Caco-2 Cells ; Calorimetry, Differential Scanning ; Drug Carriers/administration & dosage ; Drug Carriers/chemistry ; Drug Carriers/pharmacokinetics ; Drug Liberation ; Humans ; Male ; Microscopy, Electron, Scanning ; Permeability ; Poloxamer/administration & dosage ; Poloxamer/pharmacokinetics ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/pharmacokinetics ; Polyvinyls/administration & dosage ; Polyvinyls/pharmacokinetics ; Rats ; Rats, Wistar ; Resveratrol/administration & dosage ; Resveratrol/chemistry ; Solubility ; Spectroscopy, Fourier Transform Infrared
Czasopismo naukowe
Tytuł :
Anaphylaxis to the first COVID-19 vaccine: is polyethylene glycol (PEG) the culprit?
Autorzy :
Garvey LH; Allergy Clinic, Department of Dermatology and Allergy, Copenhagen University Hospital, Gentofte, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address: .
Nasser S; Department of Allergy, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
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Źródło :
British journal of anaesthesia [Br J Anaesth] 2021 Mar; Vol. 126 (3), pp. e106-e108. Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Letter
MeSH Terms :
Anaphylaxis/*chemically induced
Anaphylaxis/*diagnosis
COVID-19 Vaccines/*administration & dosage
Polyethylene Glycols/*adverse effects
COVID-19 Vaccines/adverse effects ; Humans ; Polyethylene Glycols/administration & dosage ; Surface-Active Agents/administration & dosage ; Surface-Active Agents/adverse effects
Opinia redakcyjna
Tytuł :
Ropeginterferon alfa-2b versus phlebotomy in low-risk patients with polycythaemia vera (Low-PV study): a multicentre, randomised phase 2 trial.
Autorzy :
Barbui T; FROM, Fondazione per la Ricerca Ospedale di Bergamo, Bergamo, Italy. Electronic address: .
Vannucchi AM; CRIMM, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Florence, Italy.
De Stefano V; Dipartimento di Scienze Radiologiche ed Ematologiche, Sezione di Ematologia, Università Cattolica del Sacro Cuore-Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Masciulli A; FROM, Fondazione per la Ricerca Ospedale di Bergamo, Bergamo, Italy.
Carobbio A; FROM, Fondazione per la Ricerca Ospedale di Bergamo, Bergamo, Italy.
Ferrari A; FROM, Fondazione per la Ricerca Ospedale di Bergamo, Bergamo, Italy.
Ghirardi A; FROM, Fondazione per la Ricerca Ospedale di Bergamo, Bergamo, Italy.
Rossi E; Dipartimento di Scienze Radiologiche ed Ematologiche, Sezione di Ematologia, Università Cattolica del Sacro Cuore-Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Ciceri F; Unità Operativa di Ematologia e Trapianto Midollo Osseo, IRCCS Ospedale San Raffaele, Milan, Italy.
Bonifacio M; Department of Medicine, Section of Hematology, University of Verona, Policlinico Giambattista Rossi, Verona, Italy.
Iurlo A; UOC Ematologia, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.
Palandri F; Institute of Hematology 'L & A Seràgnoli', Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Benevolo G; SC Ematologia, AOU Città della Salute e della Scienza di Torino-Presidio Ospedaliero Molinette, Turin, Italy.
Pane F; UOC di Ematologia e Trapianti di Midollo, Azienda Ospedaliera Universitaria Federico II di Napoli, Napoli, Italy; Dipartimento di Medicina clinica e Chirurgia, Università di Napoli Federico II, Napoli, Italy.
Ricco A; U.O. Ematologia con Trapianto Azienda Ospedaliera Universitaria 'Consorziale Policlinico' di Bari, Bari, Italy.
Carli G; UOC Ematologia, Azienda ULSS 8 Berica Ospedale San Bortolo di Vicenza, Vicenza, Italy.
Caramella M; Divisione Ematologia, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Rapezzi D; Divisione di Ematologia, Azienda Ospedaliera S. Croce e Carle di Cuneo, Cuneo, Italy.
Musolino C; UOC Ematologia, Azienda Ospedaliera Universitaria Policlinico 'G. Martino', Messina, Italy.
Siragusa S; Divisione Ematologia, Azienda Ospedaliera Universitaria Policlinico 'P. Giaccone', Palermo, Italy.
Rumi E; Divisione di Ematologia, Fondazione IRCCS Policlinico San Matteo Pavia, Pavia, Italy.
Patriarca A; SCDU Ematologia, Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Italy.
Cascavilla N; UO Ematologia IRCCS 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, San Giovanni Rotondo, Italy.
Mora B; Divisione UO Ematologia, ASST dei Sette Laghi, Varese, Italy.
Cacciola E; UOC di Emostasi Centro Federato FCSA, Azienda Ospedaliera Universitaria 'Policlinico Vittorio Emanuele' PO Gaspare Rodolico, Catania, Italy.
Mannarelli C; CRIMM, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Florence, Italy.
Loscocco GG; CRIMM, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Florence, Italy.
Guglielmelli P; CRIMM, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Florence, Italy.
Betti S; Dipartimento di Scienze Radiologiche ed Ematologiche, Sezione di Ematologia, Università Cattolica del Sacro Cuore-Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Lunghi F; Unità Operativa di Ematologia e Trapianto Midollo Osseo, IRCCS Ospedale San Raffaele, Milan, Italy.
Scaffidi L; Department of Medicine, Section of Hematology, University of Verona, Policlinico Giambattista Rossi, Verona, Italy.
Bucelli C; UOC Ematologia, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.
Vianelli N; Institute of Hematology 'L & A Seràgnoli', Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Bellini M; UOC Ematologia, ASST Papa Giovanni XXIII, Bergamo, Italy.
Finazzi MC; UOC Ematologia, ASST Papa Giovanni XXIII, Bergamo, Italy.
Tognoni G; IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Rambaldi A; UOC Ematologia, ASST Papa Giovanni XXIII, Bergamo, Italy; Dipartimento di Oncologia ed Emato-Oncologia, Università degli Studi di Milano, Milan, Italy.
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Źródło :
The Lancet. Haematology [Lancet Haematol] 2021 Mar; Vol. 8 (3), pp. e175-e184. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Phlebotomy*
Interferon alpha-2/*therapeutic use
Interferon-alpha/*therapeutic use
Polycythemia Vera/*drug therapy
Polyethylene Glycols/*therapeutic use
Adolescent ; Adult ; Bone Marrow/pathology ; Female ; Humans ; Interferon alpha-2/adverse effects ; Interferon-alpha/adverse effects ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; Male ; Middle Aged ; Neutropenia/etiology ; Polyethylene Glycols/adverse effects ; Polymorphism, Single Nucleotide ; Quality of Life ; Recombinant Proteins/adverse effects ; Recombinant Proteins/therapeutic use ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Using Polyethylene Glycol 3350 Plus Electrolytes in Constipated Hemodialysis Patients: A Case Series.
Autorzy :
Endo H; Department of Gastroenterology, Japan Community Health Care Organization Sendai Hospital, Japan.
Obara N; Department of Gastroenterology, Japan Community Health Care Organization Sendai Hospital, Japan.
Watanabe T; Department of Hospital Medicine, Japan Community Health Care Organization Sendai Hospital, Japan.
Sanada S; Department of Nephrology, Japan Community Health Care Organization Sendai Hospital, Japan.
Koike T; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.
Masamune A; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.
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Źródło :
Internal medicine (Tokyo, Japan) [Intern Med] 2021 Feb 01; Vol. 60 (3), pp. 379-384. Date of Electronic Publication: 2020 Aug 29.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Laxatives*/therapeutic use
Polyethylene Glycols*/adverse effects
Constipation/drug therapy ; Electrolytes/therapeutic use ; Humans ; Renal Dialysis/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Pyridine-2,6-dicarboxaldehyde-Enabled N-Terminal In Situ Growth of Polymer-Interferon α Conjugates with Significantly Improved Pharmacokinetics and In Vivo Bioactivity.
Autorzy :
Sun J; Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
Liu X; Department of Geriatric Dentistry, Beijing Laboratory of Biomedical Materials, Peking University School and Hospital of Stomatology, Beijing 100081, China.; Biomedical Engineering Department, Peking University, Beijing 100191, China.
Guo J; Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
Zhao W; Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
Gao W; Department of Geriatric Dentistry, Beijing Laboratory of Biomedical Materials, Peking University School and Hospital of Stomatology, Beijing 100081, China.; Biomedical Engineering Department, Peking University, Beijing 100191, China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Jan 13; Vol. 13 (1), pp. 88-96. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article
MeSH Terms :
Aldehydes/*chemistry
Antiviral Agents/*pharmacology
Indicators and Reagents/*chemistry
Interferon-alpha/*pharmacology
Polyethylene Glycols/*pharmacology
Pyridines/*chemistry
2',5'-Oligoadenylate Synthetase/metabolism ; Amino Acid Sequence ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacokinetics ; Half-Life ; Interferon-alpha/chemistry ; Interferon-alpha/pharmacokinetics ; Mice ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacokinetics ; Polymerization
Czasopismo naukowe
Tytuł :
A PEGylated alternating copolymeric prodrug of sulfur dioxide with glutathione responsiveness for Irinotecan delivery.
Autorzy :
Zhang Y; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. .
Zhang H
He P
Yi X
Liu X
Xiao C
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Źródło :
Journal of materials chemistry. B [J Mater Chem B] 2021 Jan 07; Vol. 9 (1), pp. 187-194. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Delivery Systems/*methods
Glutathione/*chemical synthesis
Irinotecan/*chemical synthesis
Polyethylene Glycols/*chemical synthesis
Prodrugs/*chemical synthesis
Sulfur Dioxide/*chemical synthesis
Dose-Response Relationship, Drug ; Glutathione/administration & dosage ; Glutathione/metabolism ; Hep G2 Cells ; Humans ; Irinotecan/administration & dosage ; Irinotecan/metabolism ; Nuclear Magnetic Resonance, Biomolecular/methods ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/metabolism ; Polymers/administration & dosage ; Polymers/chemical synthesis ; Polymers/metabolism ; Prodrugs/administration & dosage ; Prodrugs/metabolism ; Sulfur Dioxide/administration & dosage ; Sulfur Dioxide/metabolism
Czasopismo naukowe
Tytuł :
Single-Dose Pharmacokinetics, Pharmacodynamics and Immunogenicity, and Multiple-Dose Immunogenicity of INTP5 (Pegfilgrastim Biosimilar) Versus Reference Pegfilgrastim in Healthy Subjects.
Autorzy :
Singh I; Intas Pharmaceuticals Ltd. (Biopharma), Plot No: 423/P/A, Sarkhej-Bavla Highway, Moraiya, Sanand, Ahmedabad, Gujarat, 382213, India.
Attrey A; Lambda Therapeutic Research Ltd., Lambda House, Plot No. 38, Survey No. 388, Near Silver Oak Club, S. G. Highway, Gota, Ahmedabad, Gujarat, 382481, India.
Garg A; Lambda Therapeutic Research Ltd., Lambda House, Plot No. 38, Survey No. 388, Near Silver Oak Club, S. G. Highway, Gota, Ahmedabad, Gujarat, 382481, India.
Patel R; Lambda Therapeutic Research Ltd., Lambda House, Plot No. 38, Survey No. 388, Near Silver Oak Club, S. G. Highway, Gota, Ahmedabad, Gujarat, 382481, India.
Jose V; Intas Pharmaceuticals Ltd. (Biopharma), Plot No: 423/P/A, Sarkhej-Bavla Highway, Moraiya, Sanand, Ahmedabad, Gujarat, 382213, India. .
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Źródło :
Clinical drug investigation [Clin Drug Investig] 2021 Jan; Vol. 41 (1), pp. 29-42. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Comparative Study; Journal Article; Randomized Controlled Trial
MeSH Terms :
Biosimilar Pharmaceuticals/*administration & dosage
Filgrastim/*administration & dosage
Polyethylene Glycols/*administration & dosage
Adolescent ; Adult ; Area Under Curve ; Biosimilar Pharmaceuticals/adverse effects ; Biosimilar Pharmaceuticals/pharmacokinetics ; Cross-Over Studies ; Female ; Filgrastim/adverse effects ; Filgrastim/pharmacokinetics ; Headache/chemically induced ; Humans ; Leukocyte Count ; Male ; Musculoskeletal Pain/chemically induced ; Neutrophils/drug effects ; Polyethylene Glycols/adverse effects ; Polyethylene Glycols/pharmacokinetics ; Therapeutic Equivalency ; Young Adult
Czasopismo naukowe
Tytuł :
A pharmacokinetic evaluation of ropeginterferon alfa-2b in the treatment of polycythemia vera.
Autorzy :
Illés Á; Division of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen , Debrecen, Hungary.
Pinczés LI; Division of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen , Debrecen, Hungary.
Egyed M; Department of Hematology, University Hospital Mór Kaposi , Kaposvár, Hungary.
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Źródło :
Expert opinion on drug metabolism & toxicology [Expert Opin Drug Metab Toxicol] 2021 Jan; Vol. 17 (1), pp. 3-7. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Interferon alpha-2/*pharmacokinetics
Interferon-alpha/*pharmacokinetics
Polycythemia Vera/*drug therapy
Polyethylene Glycols/*pharmacokinetics
Alleles ; Animals ; Disease Progression ; Humans ; Interferon alpha-2/administration & dosage ; Interferon alpha-2/adverse effects ; Interferon-alpha/administration & dosage ; Interferon-alpha/adverse effects ; Janus Kinase 2/genetics ; Polycythemia Vera/genetics ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/adverse effects ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/adverse effects ; Recombinant Proteins/pharmacokinetics ; Survival Rate
Czasopismo naukowe
Tytuł :
Pooled-analysis of Lipegfilgrastim Effectiveness and Safety Among Patients With Blood Malignancies in the Real-world Setting.
Autorzy :
Pettengell R; St. George's University of London, London, U.K.; .
Wolff T; OncoResearch Lerchenfeld UG, Hamburg, Germany.
Goehler T; Onkozentrum Dresden/Freiberg, Dresden, Germany.
Cascavilla N; Casa Solievo della Sofferenza, San Giovanni Rotondo, Italy.
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Źródło :
Anticancer research [Anticancer Res] 2021 Jan; Vol. 41 (1), pp. 347-354.
Typ publikacji :
Journal Article
MeSH Terms :
Filgrastim/*adverse effects
Filgrastim/*therapeutic use
Hematologic Neoplasms/*drug therapy
Polyethylene Glycols/*adverse effects
Polyethylene Glycols/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Comorbidity ; Female ; Filgrastim/administration & dosage ; Hematologic Neoplasms/blood ; Hematologic Neoplasms/diagnosis ; Humans ; Incidence ; Male ; Middle Aged ; Neutropenia/diagnosis ; Neutropenia/etiology ; Neutropenia/prevention & control ; Polyethylene Glycols/administration & dosage ; Risk Factors ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Long-term clinical benefit of Peg-IFNα and NAs sequential anti-viral therapy on HBV related HCC.
Autorzy :
Qi WQ; Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, China.
Zhang Q; Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, China.
Wang X; Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, China.
Xu Y; Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, China.
Zhao P; Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, China.
Guo HH; Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, China.
Zhou CY; Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, China.
Sun Y; Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, China.
Liu L; Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, China.
Wang JB; Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, China.
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Źródło :
Neoplasma [Neoplasma] 2021 Jan; Vol. 68 (1), pp. 200-207. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents*/administration & dosage
Carcinoma, Hepatocellular*/drug therapy
Carcinoma, Hepatocellular*/pathology
Carcinoma, Hepatocellular*/virology
Hepatitis B*/drug therapy
Hepatitis B*/pathology
Hepatitis B virus*
Interferon-alpha*/administration & dosage
Liver Neoplasms*/drug therapy
Liver Neoplasms*/pathology
Liver Neoplasms*/virology
Nucleosides*/administration & dosage
Polyethylene Glycols*/administration & dosage
Polyethylene Glycols*/therapeutic use
Humans ; Neoplasm Recurrence, Local ; Recombinant Proteins/administration & dosage ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Efficacy and safety of lipegfilgrastim versus pegfilgrastim in elderly patients with aggressive B cell non-Hodgkin lymphoma (B-NHL): results of the randomized, open-label, non-inferiority AVOID neutropenia study.
Autorzy :
Link H; Private Practice Hematology Medical Oncology, Finkenhain 8, 67661, Kaiserslautern, Germany. .
Illerhaus G; Hematology, Oncology and Palliative Medicine Clinic, Klinikum Stuttgart, Stuttgart, Germany.
Martens UM; Hematology, Oncology and Palliative Medicine Clinic, SLK-Clinics, Heilbronn, Germany.
Salar A; Hospital del Mar Paseo Marítimo, Hematology, Barcelona, Spain.
Depenbusch R; Oncology Practice, Gütersloh, Gütersloh, Germany.
Köhler A; Hematology and Oncology Collective Practice, Asklepios Clinic Specialist Medical Centre Langen, Langen, Germany.
Engelhardt M; Internal Medicine Clinic I, Hematology, Oncology and Stem Cell Transplantation, University Clinic, Faculty of Freiburg, Freiburg, Germany.
Mahlmann S; Hematology/Oncology and Nephrology Clinic, Friedrich-Ebert-Hospital Neumünster, Neumünster, Germany.
Zaiss M; Interdiscliplinary Practice for Oncology and Hematology, Freiburg, Germany.
Lammerich A; Teva Pharmaceuticals Industries, Ulm, Germany.
Bias P; Teva Pharmaceuticals Industries, Ulm, Germany.
Buchner A; Teva Pharmaceuticals Industries, Ulm, Germany.
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Źródło :
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2021 May; Vol. 29 (5), pp. 2519-2527. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Filgrastim/*therapeutic use
Lymphoma, Non-Hodgkin/*drug therapy
Neutropenia/*chemically induced
Neutrophils/*metabolism
Polyethylene Glycols/*therapeutic use
Aged ; Female ; Filgrastim/pharmacology ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Humans ; Incidence ; Polyethylene Glycols/pharmacology
Czasopismo naukowe
Tytuł :
Dosing-related saturation of toxicity and accelerated drug clearance with pegaspargase treatment.
Autorzy :
Liu Y; Department of Pharmaceutical Sciences.
Panetta JC; Department of Pharmaceutical Sciences.
Yang W; Department of Pharmaceutical Sciences.
Karol SE; Department of Oncology, and.
Cheng C; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN.
Yang JJ; Department of Pharmaceutical Sciences.
Evans WE; Department of Pharmaceutical Sciences.
Inaba H; Department of Oncology, and.
Pui CH; Department of Oncology, and.
Jeha S; Department of Oncology, and.
Relling MV; Department of Pharmaceutical Sciences.
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Źródło :
Blood [Blood] 2020 Dec 17; Vol. 136 (25), pp. 2955-2958.
Typ publikacji :
Letter; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Asparaginase*/administration & dosage
Asparaginase*/adverse effects
Asparaginase*/pharmacokinetics
Polyethylene Glycols*/administration & dosage
Polyethylene Glycols*/adverse effects
Polyethylene Glycols*/pharmacokinetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy
Drug Elimination Routes ; Female ; Humans ; Male ; Metabolic Clearance Rate
Raport
Tytuł :
Eflapegrastim's enhancement of efficacy compared with pegfilgrastim in neutropenic rats supports potential for same-day dosing.
Autorzy :
Barrett JA; Spectrum Pharmaceuticals, Irvine, CA. Electronic address: .
Choi J; Hanmi Pharmaceuticals, Seoul, South Korea.
Lakshmikanthan S; Spectrum Pharmaceuticals, Irvine, CA.
Kim YY; Hanmi Pharmaceuticals, Seoul, South Korea.
Greene D; Spectrum Pharmaceuticals, Irvine, CA.
Kolli P; Spectrum Pharmaceuticals, Irvine, CA.
Song TH; Hanmi Pharmaceuticals, Seoul, South Korea.
Choi IY; Hanmi Pharmaceuticals, Seoul, South Korea.
Kim YH; Hanmi Pharmaceuticals, Seoul, South Korea.
Lebel F; Spectrum Pharmaceuticals, Irvine, CA.
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Źródło :
Experimental hematology [Exp Hematol] 2020 Dec; Vol. 92, pp. 51-61. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Filgrastim*/pharmacokinetics
Filgrastim*/pharmacology
Polyethylene Glycols*/pharmacokinetics
Polyethylene Glycols*/pharmacology
Neutropenia/*blood
Neutropenia/*drug therapy
Animals ; Cyclophosphamide/adverse effects ; Cyclophosphamide/pharmacology ; Docetaxel/adverse effects ; Docetaxel/pharmacology ; Histocompatibility Antigens Class I/blood ; Humans ; Male ; Mice ; Neutropenia/chemically induced ; Neutropenia/pathology ; Rats ; Rats, Sprague-Dawley ; Receptors, Fc/blood ; U937 Cells
Czasopismo naukowe
Tytuł :
Inhibition and disaggregation of amyloid β protein fibrils through conjugated polymer-core thermoresponsive micelles.
Autorzy :
Geng H; School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300401, P. R. China. .
Yuan H
Qiu L
Gao D
Cheng Y
Xing C
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Źródło :
Journal of materials chemistry. B [J Mater Chem B] 2020 Nov 18; Vol. 8 (44), pp. 10126-10135.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hot Temperature*
Micelles*
Amyloid beta-Peptides/*antagonists & inhibitors
Peptide Fragments/*antagonists & inhibitors
Polyethylene Glycols/*chemical synthesis
Polymers/*chemical synthesis
Protein Aggregates/*drug effects
Amyloid beta-Peptides/metabolism ; Animals ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; PC12 Cells ; Peptide Fragments/metabolism ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/metabolism ; Polymers/administration & dosage ; Polymers/metabolism ; Protein Aggregates/physiology ; Rats
Czasopismo naukowe
Tytuł :
Citryl-imine-PEG-ylated chitosan hydrogels - Promising materials for drug delivery applications.
Autorzy :
Ailincai D; 'Petru Poni' Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley, Iasi, Romania. Electronic address: .
Mititelu-Tartau L; 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania.
Marin L; 'Petru Poni' Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley, Iasi, Romania.
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Nov 01; Vol. 162, pp. 1323-1337. Date of Electronic Publication: 2020 Jun 26.
Typ publikacji :
Journal Article
MeSH Terms :
Chitosan*/chemistry
Chitosan*/pharmacology
Diclofenac*/chemistry
Diclofenac*/pharmacology
Drug Delivery Systems*
Hydrogels*/chemical synthesis
Hydrogels*/chemistry
Hydrogels*/pharmacology
Polyethylene Glycols*/chemistry
Polyethylene Glycols*/pharmacology
Pain/*drug therapy
Animals ; Disease Models, Animal ; Pain/metabolism ; Pain/pathology ; Rats
Czasopismo naukowe
Tytuł :
Design and evaluation of the anticancer activity of paclitaxel-loaded anisotropic-poly(lactic-co-glycolic acid) nanoparticles with PEGylated chitosan surface modifications.
Autorzy :
Choi JS; College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, South Korea; Department of Medical Management, Chodang University, 380 Muan-ro, Muan-eup, Muan-gun, Jeollanam-do 58530, South Korea.
Park JS; College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, South Korea. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Nov 01; Vol. 162, pp. 1064-1075. Date of Electronic Publication: 2020 Jun 26.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacokinetics
Antineoplastic Agents*/pharmacology
Chitosan*/chemistry
Chitosan*/pharmacokinetics
Chitosan*/pharmacology
Drug Design*
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Neoplasms*/drug therapy
Neoplasms*/metabolism
Neoplasms*/pathology
Paclitaxel*/chemistry
Paclitaxel*/pharmacokinetics
Paclitaxel*/pharmacology
Polyethylene Glycols*/chemistry
Polyethylene Glycols*/pharmacokinetics
Polyethylene Glycols*/pharmacology
Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry
Polylactic Acid-Polyglycolic Acid Copolymer*/pharmacokinetics
Polylactic Acid-Polyglycolic Acid Copolymer*/pharmacology
Drug Screening Assays, Antitumor ; Humans ; MCF-7 Cells
Czasopismo naukowe
Tytuł :
Reactive Oxygen Species-Mediated Inflammation and Apoptosis in Hand-Foot Syndrome Induced by PEGylated Liposomal Doxorubicin.
Autorzy :
Hu X; Cancer Center, The First Hospital of Jilin University, Changchun 130012, People's Republic of China.; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, People's Republic of China.
Dong M; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, People's Republic of China.
Liang X; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, People's Republic of China.
Liu Z; Cancer Center, The First Hospital of Jilin University, Changchun 130012, People's Republic of China.
Li Q; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, People's Republic of China.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 Jan 18; Vol. 16, pp. 471-480. Date of Electronic Publication: 2021 Jan 18 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Doxorubicin/*analogs & derivatives
Hand-Foot Syndrome/*etiology
Hand-Foot Syndrome/*pathology
Inflammation/*pathology
Polyethylene Glycols/*adverse effects
Reactive Oxygen Species/*metabolism
Animals ; Antibiotics, Antineoplastic/pharmacology ; Disease Models, Animal ; Doxorubicin/administration & dosage ; Doxorubicin/adverse effects ; Female ; HaCaT Cells ; Humans ; Inflammation/drug therapy ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Keratinocytes/drug effects ; Polyethylene Glycols/administration & dosage ; Rats, Wistar ; Skin/pathology
Czasopismo naukowe
Tytuł :
Drug Delivery: Hydrophobic Drug Encapsulation into Amphiphilic Block Copolymer Micelles.
Autorzy :
Chroni A; National Hellenic Research Foundation, Theoretical and Physical Chemistry Institute, Athens, Greece.
Chrysostomou V; National Hellenic Research Foundation, Theoretical and Physical Chemistry Institute, Athens, Greece.
Skandalis A; National Hellenic Research Foundation, Theoretical and Physical Chemistry Institute, Athens, Greece.
Pispas S; National Hellenic Research Foundation, Theoretical and Physical Chemistry Institute, Athens, Greece. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2207, pp. 71-83.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Micelles*
Curcumin/*chemistry
Drug Carriers/*chemistry
Polyethylene Glycols/*chemistry
Propylene Glycols/*chemistry
Curcumin/therapeutic use ; Drug Carriers/therapeutic use ; Hydrophobic and Hydrophilic Interactions ; Polyethylene Glycols/therapeutic use ; Propylene Glycols/therapeutic use ; Solubility
Czasopismo naukowe
Tytuł :
Rational design, engineer, and characterization of a novel pegylated single isomer human arginase for arginine depriving anti-cancer treatment.
Autorzy :
Yu KM; Athenex, Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, NY, USA. Electronic address: .
Pang TP; Avalon Polytom (HK) Ltd., Unit 1511-13 & 15, Level 15, Tower II, Grand Central Plaza, 138 Shatin Rural Committee Road, Shatin, Hong Kong.
Cutler M; Athenex, Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, NY, USA.
Tian M; Athenex, Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, NY, USA.
Huang L; Athenex, Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, NY, USA.
Lau JY; Athenex, Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, NY, USA; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology and Lo Ka Chung Research Centre for Natural Anti-Cancer Drug, The Hong Kong Polytechnic University, Hong Kong.
Chung SF; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology and Lo Ka Chung Research Centre for Natural Anti-Cancer Drug, The Hong Kong Polytechnic University, Hong Kong.
Lo TW; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology and Lo Ka Chung Research Centre for Natural Anti-Cancer Drug, The Hong Kong Polytechnic University, Hong Kong.
Leung TY; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology and Lo Ka Chung Research Centre for Natural Anti-Cancer Drug, The Hong Kong Polytechnic University, Hong Kong.
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118674. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*chemical synthesis
Arginase/*chemical synthesis
Arginine/*deficiency
Chemical Engineering/*methods
Polyethylene Glycols/*chemical synthesis
Animals ; Antineoplastic Agents/administration & dosage ; Arginase/administration & dosage ; Arginine/antagonists & inhibitors ; Dose-Response Relationship, Drug ; Humans ; Isoenzymes/administration & dosage ; Isoenzymes/chemical synthesis ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Polyethylene Glycols/administration & dosage ; Protein Structure, Secondary ; Rats ; Rats, Sprague-Dawley ; Treatment Outcome ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Pfizer's vaccine raises allergy concerns.
Autorzy :
de Vrieze J; Jop de Vrieze is a science journalist in Amsterdam.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jan 01; Vol. 371 (6524), pp. 10-11.
Typ publikacji :
Wiadomości
MeSH Terms :
Anaphylaxis/*etiology
COVID-19/*prevention & control
COVID-19 Vaccines/*adverse effects
Polyethylene Glycols/*adverse effects
Anaphylaxis/immunology ; COVID-19 Vaccines/chemistry ; Complement Activation ; Humans ; Nanoparticles/adverse effects ; Polyethylene Glycols/chemistry ; RNA, Messenger/chemistry ; RNA, Viral/chemistry
Periodyk

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