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Wyszukujesz frazę ""Polymorphism, Single Nucleotide genetics"" wg kryterium: Temat


Tytuł :
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
Autorzy :
Papadimitriou, Nikos
Dimou, Niki
Tsilidis, Konstantinos K
Banbury, Barbara
Martin, Richard M
Lewis, Sarah J
Kazmi, Nabila
Robinson, Timothy M
Albanes, Demetrius
Aleksandrova, Krasimira
Berndt, Sonja I
Timothy Bishop, D
Brenner, Hermann
Buchanan, Daniel D
Bueno-de-Mesquita, Bas
Campbell, Peter T
Castellví-Bel, Sergi
Chan, Andrew T
Chang-Claude, Jenny
Ellingjord-Dale, Merete
Figueiredo, Jane C
Gallinger, Steven J
Giles, Graham G
Giovannucci, Edward
Gruber, Stephen B
Gsur, Andrea
Hampe, Jochen
Hampel, Heather
Harlid, Sophia
Harrison, Tabitha A
Hoffmeister, Michael
Hopper, John L
Hsu, Li
María Huerta, José
Huyghe, Jeroen R
Jenkins, Mark A
Keku, Temitope O
Kühn, Tilman
La Vecchia, Carlo
Le Marchand, Loic
Li, Christopher I
Li, Li
Lindblom, Annika
Lindor, Noralane M
Lynch, Brigid
Markowitz, Sanford D
Masala, Giovanna
May, Anne M
Milne, Roger
Monninkhof, Evelyn
Moreno, Lorena
Moreno, Victor
Newcomb, Polly A
Offit, Kenneth
Perduca, Vittorio
Pharoah, Paul D P
Platz, Elizabeth A
Potter, John D
Rennert, Gad
Riboli, Elio
Sánchez, Maria-Jose
Schmit, Stephanie L
Schoen, Robert E
Severi, Gianluca
Sieri, Sabina
Slattery, Martha L
Song, Mingyang
Tangen, Catherine M
Thibodeau, Stephen N
Travis, Ruth C
Trichopoulou, Antonia
Ulrich, Cornelia M
van Duijnhoven, Franzel J B
Van Guelpen, Bethany
Vodicka, Pavel
White, Emily
Wolk, Alicja
Woods, Michael O
Wu, Anna H
Peters, Ulrike
Gunter, Marc J
Murphy, Neil
Pokaż więcej
Temat :
Accelerometry
Breast Neoplasms/genetics
Colorectal Neoplasms/genetics
Exercise
Female
Genetic Predisposition to Disease
Humans
Mendelian Randomization Analysis
Odds Ratio
Polymorphism, Single Nucleotide/genetics
Risk Factors
Źródło :
Papadimitriou, N, Dimou, N, Tsilidis, K K, Banbury, B, Martin, R M, Lewis, S J, Kazmi, N, Robinson, T M, Albanes, D, Aleksandrova, K, Berndt, S I, Timothy Bishop, D, Brenner, H, Buchanan, D D, Bueno-de-Mesquita, B, Campbell, P T, Castellví-Bel, S, Chan, A T, Chang-Claude, J, Ellingjord-Dale, M, Figueiredo, J C, Gallinger, S J, Giles, G G, Giovannucci, E, Gruber, S B, Gsur, A, Hampe, J, Hampel, H, Harlid, S, Harrison, T A, Hoffmeister, M, Hopper, J L, Hsu, L, María Huerta, J, Huyghe, J R, Jenkins, M A, Keku, T O, Kühn, T, La Vecchia, C, Le Marchand, L, Li, C I, Li, L, Lindblom, A, Lindor, N M, Lynch, B, Markowitz, S D, Masala, G, May, A M, Milne, R, Monninkhof, E, Moreno, L, Moreno, V, Newcomb, P A, Offit, K, Perduca, V, Pharoah, P D P, Platz, E A, Potter, J D, Rennert, G, Riboli, E, Sánchez, M-J, Schmit, S L, Schoen, R E, Severi, G, Sieri, S, Slattery, M L, Song, M, Tangen, C M, Thibodeau, S N, Travis, R C, Trichopoulou, A, Ulrich, C M, van Duijnhoven, F J B, Van Guelpen, B, Vodicka, P, White, E, Wolk, A, Woods, M O, Wu, A H, Peters, U, Gunter, M J & Murphy, N 2020, ' Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis ', Nature Communications, vol. 11, 597 . https://doi.org/10.1038/s41467-020-14389-8
Opis pliku :
application/pdf
Tytuł :
On the population dynamics of junk:a review on the population genomics of transposable elements
Autorzy :
Bourgeois, Yann
Boissinot, Stéphane
Pokaż więcej
Temat :
DNA Transposable Elements/genetics
Evolution, Molecular
Genetics, Population
Humans
Metagenomics
Polymorphism, Single Nucleotide/genetics
Population Dynamics
Selection, Genetic
Źródło :
Bourgeois, Y & Boissinot, S 2019, ' On the population dynamics of junk : a review on the population genomics of transposable elements ', Genes, vol. 10, no. 6 . https://doi.org/10.3390/genes10060419
Opis pliku :
application/pdf
Tytuł :
Development and characterisation of interspecific hybrid lines with genome-wide introgressions from Triticum timopheevii in a hexaploid wheat background
Autorzy :
King, Julie
Devi, Urmila
Grewal, Surbhi
Yang, Cai-yun
Hubbart-Edwards, Stella
Scholefield, Duncan
Ashling, Stephen
Burridge, Amanda
King, Ian P
Pokaż więcej
Temat :
Triticum timopheevii
Research Article
Wild relatives
Botany
Genetic Loci
Genome, Plant
Triticum/genetics
Polyploidy
Chromosomes, Plant/genetics
Hybridization, Genetic
Wheat
Ecotype
Recombination, Genetic/genetics
food and beverages
Species Specificity
Genetic Linkage
Introgression
Genotype
Seeds/genetics
Genetic mapping
SNP
Chromosome Mapping
Journal Article
QK1-989
Interspecific hybrid
Crosses, Genetic
Genetic Markers
Polymorphism, Single Nucleotide/genetics
Źródło :
BMC Plant Biology, Vol 19, Iss 1, Pp 1-14 (2019)
Devi, U, Grewal, S, Yang, C-Y, Hubbart-Edwards, S, Scholefield, D, Ashling, S, Burridge, A, King, I P & King, J 2019, ' Development and characterisation of interspecific hybrid lines with genome-wide introgressions from Triticum timopheevii in a hexaploid wheat background ', BMC Plant Biology, vol. 19, no. 1, 183 . https://doi.org/10.1186/s12870-019-1785-z
Opis pliku :
application/pdf
Tytuł :
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Autorzy :
Huckins, Laura M
Dobbyn, Amanda
Ruderfer, Douglas M
Hoffman, Gabriel
Wang, Weiqing
Pardiñas, Antonio F
Rajagopal, Veera M
Als, Thomas D
T Nguyen, Hoang
Girdhar, Kiran
Boocock, James
Roussos, Panos
Fromer, Menachem
Kramer, Robin
Domenici, Enrico
Gamazon, Eric R
Purcell, Shaun
Demontis, Ditte
Børglum, Anders D
Walters, James T R
O'Donovan, Michael C
Sullivan, Patrick
Owen, Michael J
Devlin, Bernie
Sieberts, Solveig K
Cox, Nancy J
Im, Hae Kyung
Sklar, Pamela
Stahl, Eli A
Mortensen, Preben Bo
Pokaż więcej
Temat :
TRAITS
CHILDHOOD
TRANSCRIPTOME
Quantitative Trait Loci/genetics
ASSOCIATION
VARIANTS
Genome-Wide Association Study/methods
PSYCHOSIS
Genotype
Brain/physiopathology
MOUSE
COGNITIVE DEFICITS
DISORDER
Transcriptome/genetics
Schizophrenia/genetics
ACUTE INTERMITTENT PORPHYRIA
Risk
Genetic Predisposition to Disease
Humans
Human medicine
Case-Control Studies
Gene Expression/genetics
Polymorphism, Single Nucleotide/genetics
Źródło :
Huckins, L M, Dobbyn, A, Ruderfer, D M, Hoffman, G, Wang, W, Pardiñas, A F, Rajagopal, V M, Als, T D, T Nguyen, H, Girdhar, K, Boocock, J, Roussos, P, Fromer, M, Kramer, R, Domenici, E, Gamazon, E R, Purcell, S, Demontis, D, Børglum, A D, Walters, J T R, O'Donovan, M C, Sullivan, P, Owen, M J, Devlin, B, Sieberts, S K, Cox, N J, Im, H K, Sklar, P, Stahl, E A, CommonMind Consortium, The Schizophrenia Working Group of the Psychiatric Genomics Consortium & iPSYCH-GEMS Schizophrenia Working Group 2019, ' Gene expression imputation across multiple brain regions provides insights into schizophrenia risk ', Nature Genetics, vol. 51, no. 4, pp. 659-674 . https://doi.org/10.1038/s41588-019-0364-4
Opis pliku :
text
Tytuł :
New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries
Autorzy :
Shrine, Nick
Guyatt, Anna L
Erzurumluoglu, A Mesut
Jackson, Victoria E
Hobbs, Brian D
Melbourne, Carl A
Batini, Chiara
Fawcett, Katherine A
Song, Kijoung
Sakornsakolpat, Phuwanat
Li, Xingnan
Boxall, Ruth
Reeve, Nicola F
Obeidat, Ma'en
Zhao, Jing Hua
Wielscher, Matthias
Weiss, Stefan
Kentistou, Katherine A
Cook, James P
Sun, Benjamin B
Zhou, Jian
Hui, Jennie
Karrasch, Stefan
Imboden, Medea
Harris, Sarah E
Marten, Jonathan
Enroth, Stefan
Kerr, Shona M
Surakka, Ida
Vitart, Veronique
Lehtimäki, Terho
Allen, Richard J
Bakke, Per S
Beaty, Terri H
Bleecker, Eugene R
Bossé, Yohan
Brandsma, Corry-Anke
Chen, Zhengming
Crapo, James D
Danesh, John
DeMeo, Dawn L
Dudbridge, Frank
Ewert, Ralf
Gieger, Christian
Gulsvik, Amund
Hansell, Anna L
Hao, Ke
Hoffman, Joshua D
Li, Xuan
Van den Berge, Maarten
Pokaż więcej
Temat :
Risk Factors
Aged
VARIANTS
Middle Aged
Genome-Wide Association Study/methods
COPD
HERITABILITY
GWAS
Genetic Predisposition to Disease/genetics
Lung/physiopathology
respiratory tract diseases
Smoking/genetics
Pulmonary Disease, Chronic Obstructive/genetics
GENOME-WIDE ASSOCIATION
LOCI
Aged, 80 and over
Female
Humans
Male
Case-Control Studies
Polymorphism, Single Nucleotide/genetics
Źródło :
Understanding Society Scientific Group 2019, ' New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, no. 3, pp. 481-493 . https://doi.org/10.1038/s41588-018-0321-7
Nature Genetics, 51(3), 481 - 493. Nature Publishing Group
Shrine, N R G, Guyatt, A, Erzurumluoglu, A M, Jackson, V E, Hobbs, B D, Melbourne, C, Batini, C, Fawcett, K A, Song, K, Sakornsakolpat, P, Li, X, Boxall, R, Reeve, N F, Obeidat, M, Zhao, J H, Wielscher, M, Weiss, S, Kentistou, K, Cook, J P, Sun, B B, Zhou, J, Hui, J, Karrasch, S, Imboden, M, Harris, S, Marten, J, Enroth, S, Kerr, S, Surakka, I, Vitart, V, Lehtimäki, T, Allen, R J, Bakke, P S, Beaty, T H, Bleecker, E R, Bossé, Y, Brandsma, C-A, Chen, Z, Crapo, J D, Danesh, J, Demeo, D L, Dudbridge, F, Ewert, R, Gieger, C, Gulsvik, A, Hansell, A L, Hao, K, Hoffman, J D, Hokanson, J E, Homuth, G, Joshi, P, Joubert, P, Langenberg, C, Li, X, Li, L, Lin, K, Lind, L, Locantore, N, Luan, J, Mahajan, A, Maranville, J C, Murray, A, Nickle, D C, Packer, R, Parker, M M, Paynton, M L, Porteous, D, Prokopenko, D, Qiao, D, Rawal, R, Runz, H, Sayers, I, Sin, D D, Smith, B H, Soler Artigas, M, Sparrow, D, Tal-Singer, R, Timmers, P RHJ, van den Berge, M, Woodruff, P G, Yerges-Armstrong, L M, Troyanskaya, O G, Raitakar, O, Kähönen, M, Polasek, O, Rudan, I, Deary, I, Probst-Hensch, N M, Schulz, H, James, A L, Wilson, J F, Stubbe, B, Zeggini, E, Jarvelin, M-R, Wareham, N, Silverman, E K, Hayward, C, Morris, A P, Butterworth, A S, Scott, R A, Walters, R G, Meyers, D A, Cho, M H, Strachan, D P, Hall, I P & Tobin, M D & Wain, L V 2019, ' New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, pp. 481–493 . https://doi.org/10.1038/s41588-018-0321-7
Opis pliku :
application/pdf
Tytuł :
Identification of common genetic risk variants for autism spectrum disorder
Autorzy :
Grove, Jakob
Ripke, Stephan
Als, Thomas D.
Mattheisen, Manuel
Walters, Raymond K.
Won, Hyejung
Pallesen, Jonatan
Agerbo, Esben
Andreassen, Ole A.
Anney, Richard
Awashti, Swapnil
Belliveau, Rich
Bettella, Francesco
Buxbaum, Joseph D.
Bybjerg-Grauholm, Jonas
Bækvad-Hansen, Marie
Cerrato, Felecia
Chambert, Kimberly
Christensen, Jane H.
Churchhouse, Claire
Dellenvall, Karin
Demontis, Ditte
De Rubeis, Silvia
Devlin, Bernie
Djurovic, Srdjan
Dumont, Ashley L.
Goldstein, Jacqueline I.
Hansen, Christine S.
Hauberg, Mads Engel
Hollegaard, Mads V.
Hope, Sigrun
Howrigan, Daniel P.
Huang, Hailiang
Hultman, Christina M.
Klei, Lambertus
Maller, Julian
Martin, Joanna
Pedersen, Carsten Bøcker
Davey Smith, George
Pourcain, Beate St
Adams, Mark J.
Dunn, Erin C
Knowles, James A.
Medland, Sarah E
Owen, Michael J.
Smith, Daniel J.
Tansey, Katherine E.
Yang, Jian
Lewis, Glyn
Madden, Pamela A.F.
Pokaż więcej
Temat :
Multifactorial Inheritance/genetics
Genome-Wide Association Study/methods
Research Support, Non-U.S. Gov't
HERITABILITY
Denmark
behavioral disciplines and activities
LD SCORE REGRESSION
LOCI
NEURITE OUTGROWTH
Female
Child, Preschool
Case-Control Studies
Phenotype
METAANALYSIS
Risk Factors
CELL-SURFACE
Autism Spectrum Disorder/genetics
Article
mental disorders
DE-NOVO
Genetic Predisposition to Disease/genetics
Research Support, N.I.H., Extramural
SIMONS SIMPLEX COLLECTION
Adolescent
Journal Article
GENOME-WIDE ASSOCIATION
SYNAPTIC PLASTICITY
Humans
Male
Polymorphism, Single Nucleotide/genetics
Child
Źródło :
Nature Genetics, 51(3), 431 - 444. Nature Publishing Group
Grove, J, Ripke, S, Als, T D, Mattheisen, M, Walters, R K, Won, H, Pallesen, J, Agerbo, E, Andreassen, O A, Anney, R, Awashti, S, Belliveau, R, Bettella, F, Buxbaum, J D, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Cerrato, F, Chambert, K, Christensen, J H, Churchhouse, C, Dellenvall, K, Demontis, D, De Rubeis, S, Devlin, B, Djurovic, S, Dumont, A L, Goldstein, J I, Hansen, C S, Hauberg, M E, Hollegaard, M V, Hope, S, Howrigan, D P, Huang, H, Hultman, C M, Klei, L, Maller, J, Martin, J, Pedersen, C B, Davey Smith, G, Pourcain, B S & the 23 and Me Research Team 2019, ' Identification of common genetic risk variants for autism spectrum disorder ', Nature Genetics, vol. 51, no. 3, pp. 431-444 . https://doi.org/10.1038/s41588-019-0344-8
Maller, J, Martin, J, Martin, A, Moran, J, Nyegaard, M, Naerland, T, Palmer, D, Palotie, A, Bocker Perdersen, C, Giortz Pedersen, M, dPoterba, T, Buchhave Poulsen, J, St Poucain, B, Qvist, P, Rehnstrom, K, Reichenberg, A, Reichert, J, Robinson, E B, Roeder, K, Roussos, P, Saemundsen, E, Sandin, S, Satterstrom, F K, Smith, G D, Stefansson, H, Steinberg, S, Stevens, C R, Sullivan, P F, Turley, P, Walters, G B, Xu, X, Stefansson, K, Geschwind, D H, Nordentoft, M, Hougaard, D M, Werge, T, Mors, O & Mortensen, P B & Neale, B M & Daly, M J & Borglum, A D 2019, ' Identification of common genetic risk variants for autism spectrum disorder ', Nature Genetics, vol. 51, no. 3, pp. 431-+ . https://doi.org/10.1038/s41588-019-0344-8
Grove, J, Ripke, S, Als, T D, Mattheisen, M, Walters, R K, Won, H, Pallesen, J, Agerbo, E, Andreassen, O A, Anney, R, Awashti, S, Belliveau, R, Bettella, F, Buxbaum, J D, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Cerrato, F, Chambert, K, Christensen, J H, Churchhouse, C, Dellenvall, K, Demontis, D, De Rubeis, S, Devlin, B, Djurovic, S, Dumont, A L, Goldstein, J I, Hansen, C S, Hauberg, M E, Hollegaard, M V, Hope, S, Howrigan, D P, Huang, H, Hultman, C M, Klei, L, Maller, J, Martin, J, Martin, A R, Moran, J L, Nyegaard, M, Nærland, T, Palmer, D S, Palotie, A, Pedersen, C B, Pedersen, M G, dPoterba, T, Poulsen, J B, Pourcain, B S, Qvist, P, Rehnström, K, Reichenberg, A, Reichert, J, Robinson, E B, Roeder, K, Roussos, P, Saemundsen, E, Sandin, S, Satterstrom, F K, Smith, G D, Stefansson, H, Steinberg, S, Stevens, C, Sullivan, P F, Turley, P, Walters, G B, Xu, X, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 23andMe Research Team, Stefansson, K, Geschwind, D H, Nordentoft, M, Hougaard, D M, Werge, T, Mors, O, Mortensen, P B, Neale, B M, Daly, M J & Børglum, A D 2019, ' Identification of common genetic risk variants for autism spectrum disorder ', Nature Genetics, vol. 51, no. 3, pp. 431-444 . https://doi.org/10.1038/s41588-019-0344-8
Opis pliku :
application/pdf
Tytuł :
Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila.
Autorzy :
Rech, Gabriel E.
Bogaerts-Márquez, María
Merenciano, Miriam
Horváth, Vivien
Fiston-Lavier, Anna-Sophie
Venkataram, Sandeep
Quesneville, Hadi
González, Josefa
Barrón, Maite G.
Villanueva-Cañas, José Luis
Luyten, Isabelle
Petrov, Dmitri A.
Pokaż więcej
Temat :
Evolutionary Adaptation
Animal Models
Eukaryota
Alcohols
Evolutionary Processes
Chemical Compounds
Invertebrate Genomics
QH426-470
Physical Sciences
MESH: Selection, Genetic: genetics
MESH: Drosophila melanogaster: genetics
Genome Analysis
MESH: Gene Frequency: genetics
Animals
Biology and Life Sciences
Arthropoda
MESH: DNA Transposable Elements: genetics
MESH: Genome, Insect: genetics
Insects
MESH: Gene Expression Regulation, Developmental: genetics
Chi Square Tests
Organisms
Animal Genomics
Gene Expression
Statistical Methods
Computational Biology
MESH: Animals
Research Article
Mathematics
Drosophila Melanogaster
MESH: Stress, Physiological: genetics
Mathematical and Statistical Techniques
Statistical Hypothesis Testing
MESH: Polymorphism, Single Nucleotide: genetics
Genetics
Evolutionary Biology
Organic Chemistry
Genomics
MESH: Mutation: genetics
Experimental Organism Systems
Chemistry
MESH: Behavior, Animal: physiology
Research and Analysis Methods
Animal Studies
Gene Ontologies
[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]
Model Organisms
Drosophila
MESH: Evolution, Molecular
Organic Compounds
Invertebrates
sequence
evolution
population
adaptation
melanogaster
reference panel
positive selection
insecticide resistance
genetic-variation
genome-wide patterns
Statistics
Źródło :
Plos Genetics 2 (15), 1-33. (2019)
PLoS Genetics, Vol 15, Iss 2, p e1007900 (2019)
PLoS Genetics, Public Library of Science, 2019, 15 (2), pp.e1007900. ⟨10.1371/journal.pgen.1007900⟩
Opis pliku :
application/pdf
Tytuł :
Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients
Autorzy :
Canet, Luz M
Sánchez-Maldonado, Jose M
Cáliz, Rafael
Ramos, Ana Rodríguez
Lupiañez, Carmen B
Canhão, Helena
Martínez-Bueno, Manuel
Escudero, Alejandro
Segura-Catena, Juana
Sorensen, Signe B
Hetland, Merete L
Soto-Pino, María José
Ferrer, Miguel A
García, Antonio
Glintborg, Bente
Filipescu, Ileana
Pérez-Pampin, Eva
González-Utrilla, Alfonso
Nevot, Miguel Ángel López
Conesa-Zamora, Pablo
Broeder, Alfons den
De Vita, Salvatore
Jacobsen, Sven Erik Hobe
Collantes-Estevez, Eduardo
Quartuccio, Luca
Canzian, Federico
Fonseca, João E
Coenen, Marieke J H
Andersen, Vibeke
Sainz, Juan
Pokaż więcej
Temat :
Antirheumatic Agents/therapeutic use
Arthritis, Rheumatoid/drug therapy
Case-Control Studies
Cytochrome P-450 CYP2C9/genetics
Cytochrome P-450 CYP3A/genetics
Estrogen Receptor beta/genetics
Female
Gonadal Steroid Hormones/genetics
Haplotypes/genetics
Humans
Male
Metabolic Detoxication, Phase I/genetics
Polymorphism, Single Nucleotide/genetics
Tumor Necrosis Factor-alpha/antagonists & inhibitors
Ubiquitin-Protein Ligases/genetics
Źródło :
Canet, L M, Sánchez-Maldonado, J M, Cáliz, R, Ramos, A R, Lupiañez, C B, Canhão, H, Martínez-Bueno, M, Escudero, A, Segura-Catena, J, Sorensen, S B, Hetland, M L, Soto-Pino, M J, Ferrer, M A, García, A, Glintborg, B, Filipescu, I, Pérez-Pampin, E, González-Utrilla, A, Nevot, M Á L, Conesa-Zamora, P, Broeder, A D, De Vita, S, Jacobsen, S E H, Collantes-Estevez, E, Quartuccio, L, Canzian, F, Fonseca, J E, Coenen, M J H, Andersen, V & Sainz, J 2019, ' Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients ', The Pharmacogenomics Journal, vol. 19, pp. 83-96 . https://doi.org/10.1038/s41397-018-0057-x
Tytuł :
GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals
Autorzy :
Iotchkova, Valentina
Ritchie, Graham R.S.
Geihs, Matthias
Morganella, Sandro
Min, Josine L.
Walter, Klaudia
Timpson, Nicholas John
Dunham, Ian
Birney, Ewan
Soranzo, Nicole
Pokaż więcej
Temat :
Phenotype
Software
Disease/genetics
Quantitative Trait Loci/genetics
Genome-Wide Association Study/methods
Article
Research Support, Non-U.S. Gov't
Genomics/methods
Regulatory Sequences, Nucleic Acid/genetics
ICEP
Journal Article
Genome/genetics
Humans
Molecular Sequence Annotation/methods
Polymorphism, Single Nucleotide/genetics
Źródło :
Lotchkova, V, Ritchie, G R S, Geihs, M, Morganella, S, Min, J, Walter, K, Timpson, N, Dunham, I, Birney, E, Soranzo, N 2019, ' GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals ', Nature Genetics, vol. 51, no. 2, pp. 343-353 . https://doi.org/10.1038/s41588-018-0322-6
Opis pliku :
application/pdf
Tytuł :
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances.
Autorzy :
Timmers, P.R.
Mounier, N.
Lall, K.
Fischer, K.
Ning, Z.
Feng, X.
Bretherick, A.D.
Clark, D.W.
Agbessi, M.
Ahsan, H.
Alves, I.
Andiappan, A.
Awadalla, P.
Battle, A.
Bonder, M.J.
Boomsma, D.
Christiansen, M.
Claringbould, A.
Deelen, P.
van Dongen, J.
Esko, T.
Favé, M.
Franke, L.
Frayling, T.
Gharib, S.A.
Gibson, G.
Hemani, G.
Jansen, R.
Kalnapenkis, A.
Kasela, S.
Kettunen, J.
Kim, Y.
Kirsten, H.
Kovacs, P.
Krohn, K.
Kronberg-Guzman, J.
Kukushkina, V.
Kutalik, Z.
Kähönen, M.
Lee, B.
Lehtimäki, T.
Loeffler, M.
Marigorta, U.
Metspalu, A.
van Meurs, J.
Milani, L.
Müller-Nurasyid, M.
Nauck, M.
Nivard, M.
Penninx, B.
Perola, M.
Pervjakova, N.
Pierce, B.
Powell, J.
Prokisch, H.
Psaty, B.M.
Raitakari, O.
Ring, S.
Ripatti, S.
Rotzschke, O.
Ruëger, S.
Saha, A.
Scholz, M.
Schramm, K.
Seppälä, I.
Stumvoll, M.
Sullivan, P.
Teumer, A.
Thiery, J.
Tong, L.
Tönjes, A.
Verlouw, J.
Visscher, P.M.
Võsa, U.
Völker, U.
Yaghootkar, H.
Yang, J.
Zeng, B.
Zhang, F.
Shen, X.
Wilson, J.F.
Joshi, P.K.
Pokaż więcej
Temat :
Age Factors
Aged
Bayes Theorem
DNA Methylation/genetics
Disease/genetics
Female
Genetic Loci
Genome-Wide Association Study
Genomics
Humans
Longevity/genetics
Male
Middle Aged
Multifactorial Inheritance/genetics
Parents
Polymorphism, Single Nucleotide/genetics
Risk Factors
Sex Characteristics
Signal Transduction/genetics
Survival Analysis
complex trait
genetics
genomics
human
lifespan
longevity
Źródło :
eLife, vol. 8, pp. e39856
Opis pliku :
application/pdf
Tytuł :
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Autorzy :
Demontis, Ditte
Walters, Raymond K.
Martin, Joanna
Mattheisen, Manuel
Als, Thomas D.
Agerbo, Esben
Baldursson, Gísli
Belliveau, Rich
Bybjerg-Grauholm, Jonas
Bækvad-Hansen, Marie
Cerrato, Felecia
Chambert, Kimberly
Churchhouse, Claire
Dumont, Ashley
Eriksson, Nicholas
Gandal, Michael
Goldstein, Jacqueline I.
Grasby, Katrina L.
Grove, Jakob
Gudmundsson, Olafur O.
Hansen, Christine S.
Hauberg, Mads Engel
Hollegaard, Mads V.
Howrigan, Daniel P.
Huang, Hailiang
Maller, Julian B.
Martin, Alicia R.
Martin, Nicholas G.
Moran, Jennifer
Pallesen, Jonatan
Palmer, Duncan S.
Pedersen, Carsten Bøcker
Pedersen, Marianne Giørtz
Poterba, Timothy
Poulsen, Jesper Buchhave
Ripke, Stephan
Robinson, Elise B.
Satterstrom, F. Kyle
Smith, George Davey
Davies, Gareth E.
Evans, David M.
Kemp, John P.
Ring, Susan
Stergiakouli, Evie
Pourcain, Beate St
Stoltenberg, Camilla
Timpson, Nicholas J.
Langley, Kate
Thapar, Anita
Medland, Sarah E.
Pokaż więcej
Temat :
Genetic Loci/genetics
Brain/physiology
Genome-Wide Association Study/methods
Research Support, Non-U.S. Gov't
Attention Deficit Disorder with Hyperactivity/genetics
behavioral disciplines and activities
Female
Child, Preschool
Meta-Analysis
mental disorders
Genetic Predisposition to Disease/genetics
Research Support, N.I.H., Extramural
Gene Expression Regulation/genetics
Cohort Studies
Adolescent
Risk
Journal Article
Humans
Male
Child
Polymorphism, Single Nucleotide/genetics
Źródło :
the 23 and Me Research Team, Demontis, D, Walters, R K, Martin, J, Mattheisen, M, Als, T D, Agerbo, E, Baldursson, G, Belliveau, R, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Cerrato, F, Chambert, K, Churchhouse, C, Dumont, A, Eriksson, N, Gandal, M, Goldstein, J I, Grasby, K L, Grove, J, Gudmundsson, O O, Hansen, C S, Hauberg, M E, Hollegaard, M V, Howrigan, D P, Huang, H, Maller, J B, Martin, A R, Martin, N G, Moran, J, Pallesen, J, Palmer, D S, Pedersen, C B, Pedersen, M G, Poterba, T, Poulsen, J B, Ripke, S, Robinson, E B, Satterstrom, F K, Smith, G D, Davies, G E, Evans, D M, Kemp, J P, Ring, S, Stergiakouli, E, Pourcain, B S, Stoltenberg, C, Timpson, N J & Langley, K & Thapar, A & Medland, S E 2019, ' Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder ', Nature Genetics, vol. 51, no. 1, pp. 63-75 . https://doi.org/10.1038/s41588-018-0269-7
Opis pliku :
application/pdf
Tytuł :
Evolutionary history of human colitis-associated colorectal cancer
Autorzy :
Tomlinson, Ian P M
Graham, Trevor A
Baker, Ann-Marie
Cross, William
Curtius, Kit
Al Bakir, Ibrahim
Choi, Chang-Ho Ryan
Davis, Hayley Louise
Temko, Daniel
Biswas, Sujata
Martinez, Pierre
Williams, Marc J
Lindsay, James O
Feakins, Roger
Vega, Roser
Hayes, Stephen J
McDonald, Stuart A C
Moorghen, Morgan
Silver, Andrew
East, James E
Wright, Nicholas A
Wang, Lai Mun
Rodriguez-Justo, Manuel
Jansen, Marnix
Hart, Ailsa L
Leedham, Simon J
Pokaż więcej
Temat :
Risk Assessment
colorectal cancer
Colonoscopy/methods
Colitis, Ulcerative/genetics
Disease Progression
Middle Aged
digestive system diseases
inflammatory bowel disease
Colorectal Neoplasms/genetics
dysplasia
IBD - genetics, colorectal cancer, dysplasia, inflammatory bowel disease
Severity of Illness Index
Cell Transformation, Neoplastic/genetics
Gene Expression Regulation, Neoplastic
IBD - genetics
Phylogeny
Female
Humans
Male
Polymorphism, Single Nucleotide/genetics
Źródło :
Baker, A-M, Cross, W, Curtius, K, Al Bakir, I, Choi, C-H R, Davis, H L, Temko, D, Biswas, S, Martinez, P, Williams, M J, Lindsay, J O, Feakins, R, Vega, R, Hayes, S J, Tomlinson, I P M, McDonald, S A C, Moorghen, M, Silver, A, East, J E, Wright, N A, Wang, L M, Rodriguez-Justo, M, Jansen, M, Hart, A L, Leedham, S J & Graham, T A 2018, ' Evolutionary history of human colitis-associated colorectal cancer ', Gut, vol. 68, no. 6, pp. 985-995 . https://doi.org/10.1136/gutjnl-2018-316191
Baker, A, Cross, W, Curtius, K, Al Bakir, I, Choi, C R, Davis, H L, Temko, D, Biswas, S, Martinez, P, Williams, M J, Lindsay, J O, Feakins, R, Vega, R, Hayes, S J, Tomlinson, I P M, Mcdonald, S A C, Moorghen, M, Silver, A, East, J E, Wright, N A, Wang, L M, Rodriguez-justo, M, Jansen, M, Hart, A L, Leedham, S J & Graham, T A 2018, ' Evolutionary history of human colitis-associated colorectal cancer ', Gut, pp. gutjnl-2018-316191 . https://doi.org/10.1136/gutjnl-2018-316191
Opis pliku :
application/pdf; text
Tytuł :
Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.
Autorzy :
Dennis, Joe
Bruinsma, Fiona
Cunningham, Julie M.
Giles, Graham G.
Jakubowska, Anna
Li, Zheng
Sellers, Thomas A.
Pharoah, Paul D. P.
Goode, Ellen L.
Earp, Madalene
Tyrer, Jonathan P.
Winham, Stacey J.
Lin, Hui-Yi
Chornokur, Ganna
Aben, Katja K. H.
Anton‐Culver, Hoda
Antonenkova, Natalia
Bandera, Elisa V.
Bean, Yukie T.
Beckmann, Matthias W.
Bjorge, Line
Bogdanova, Natalia
Brinton, Louise A.
Brooks-Wilson, Angela
Bunker, Clareann H.
Butzow, Ralf
Campbell, Ian G.
Carty, Karen
Chang-Claude, Jenny
Cook, Linda S.
Cramer, Daniel W
Cybulski, Cezary
Dansonka-Mieszkowska, Agnieszka
Despierre, Evelyn
Doherty, Jennifer A.
Dörk, Thilo
du Bois, Andreas
Dürst, Matthias
Easton, Douglas F.
Eccles, Diana M.
Edwards, Robert P.
Ekici, Arif B.
Fasching, Peter A.
Fridley, Brooke L.
Gentry-Maharaj, Aleksandra
Glasspool, Rosalind
Goodman, Marc T.
Gronwald, Jacek
Harter, Philipp
Hein, Alexander
Heitz, Florian
Hildebrandt, Michelle A. T.
Hillemanns, Peter
Hogdall, Claus K.
Høgdall, Estrid
Hosono, Satoyo
Iversen, Edwin S.
Jensen, Allan
Ji, Bu-Tian
Jung, Audrey Y.
Karlan, Beth Y.
Kellar, Melissa
Kiemeney, Lambertus A.
Kiong Lim, Boon
Kjaer, Susanne K.
Krakstad, Camilla
Kupryjanczyk, Jolanta
Lambrechts, Diether
Lambrechts, Sandrina
Le, Nhu D.
Lele, Shashi
Lester, Jenny
Levine, Douglas A.
Liang, Dong
Lissowska, Jolanta
Lu, Karen
Lubinski, Jan
Lundvall, Lene
Massuger, Leon F. A. G.
Matsuo, Keitaro
McGuire, Valerie
McLaughlin, John R.
McNeish, Iain
Menon, Usha
Milne, Roger L.
Modugno, Francesmary
Moysich, Kirsten B.
Ness, Roberta B.
Nevanlinna, Heli
Odunsi, Kunle
Olson, Sara H.
Orlow, Irene
Orsulic, Sandra
Paul, James
Pejovic, Tanja
Pelttari, Liisa M.
Permuth, Jenny B.
Pike, Malcolm C.
Poole, Elizabeth M.
Rosen, Barry
Rossing, Mary Anne
Rothstein, Joseph H.
Runnebaum, Ingo B.
Rzepecka, Iwona K.
Schernhammer, Eva
Schwaab, Ira
Shu, Xiao-Ou
Shvetsov, Yurii B.
Siddiqui, Nadeem
Sieh, Weiva
Song, Honglin
Southey, Melissa C.
Spiewankiewicz, Beata
Sucheston-Campbell, Lara
Tangen, Ingvild L.
Teo, Soo-Hwang
Terry, Kathryn L.
Thompson, Pamela J.
Thomsen, Lotte
Tworoger, Shelley S.
van Altena, Anne M.
Vergote, Ignace
Vestrheim Thomsen, Liv Cecilie
Vierkant, Robert A.
Walsh, Christine S.
Wang-Gohrke, Shan
Wentzensen, Nicolas
Whittemore, Alice S.
Wicklund, Kristine G.
Wilkens, Lynne R.
Woo, Yin-Ling
Wu, Anna H.
Wu, Xifeng
Xiang, Yong-Bing
Yang, Hannah
Zheng, Wei
Ziogas, Argyrios
Lee, Alice W
Pearce, Celeste L.
Berchuck, Andrew
Schildkraut, Joellen M.
Ramus, Susan J.
Monteiro, Alvaro N. A.
Narod, Steven A.
Gayther, Simon A.
Kelemen, Linda E.
Chenevix-Trench, Georgia
Risch, Harvey A.
Phelan, Catherine M.
Pokaż więcej
Temat :
Cell Membranes
Human Genetics
Oncology
Research Support, Non-U.S. Gov't
endocrine system diseases
Signaling Molecules
Histology
Genome Analysis
Polymorphism, Single Nucleotide
Research Support, N.I.H., Intramural
Science & Technology - Other Topics
Female
Guanosine Triphosphatase
3122 Cancers
Risk Factors
MD Multidisciplinary
Biology and Life Sciences
Signal Transduction
Monomeric GTP-Binding Proteins/genetics
Guanine Nucleotide Exchange Factors
Enzymology
Genotype
Rho Guanine Nucleotide Exchange Factors
Ras Signaling
Science & Technology
Gene Regulation
Science
Research Support, U.S. Gov't, Non-P.H.S
Gene Expression
SUPER-ENHANCERS
Polymorphism, Single Nucleotide/genetics
Carcinoma, Ovarian Epithelial
Computational Biology
Research Article
TRAITS
3123 Gynaecology and paediatrics
Anatomy
Carcinoma, Ovarian Epithelial/genetics
Enzymes
Quantitative Trait Loci/genetics
Multidisciplinary Sciences
Quantitative Trait Loci
Research Support, U.S. Gov't, P.H.S
Membrane Proteins
Genetics
3111 Biomedicine
Invasive Tumors
Proteins
A Kinase Anchor Proteins/genetics
Genomics
Cancers and Neoplasms
Hydrolases
Medicine
Monomeric GTP-Binding Proteins
Cell Biology
Research Support, N.I.H., Extramural
Cellular Structures and Organelles
CARCINOMA
Biochemistry
Cell Signaling
General Science & Technology
Genetic Association Studies
Journal Article
Medicine and Health Sciences
Genetic Predisposition to Disease
GENOME-WIDE ASSOCIATION
A Kinase Anchor Proteins
Genome-Wide Association Studies
Humans
Rho Guanine Nucleotide Exchange Factors/genetics
Źródło :
Earp, M, Tyrer, J P, Winham, S J, Lin, H-Y, Chornokur, G, Dennis, J, Aben, K K H, Anton-Culver, H, Antonenkova, N, Bandera, E V, Bean, Y T, Beckmann, M W, Bjorge, L, Bogdanova, N, Brinton, L A, Brooks-Wilson, A, Bruinsma, F, Bunker, C H, Butzow, R, Campbell, I G, Carty, K, Chang-Claude, J, Cook, L S, Cramer, D W, Cunningham, J M, Cybulski, C, Dansonka-Mieszkowska, A, Despierre, E, Doherty, J A, Dörk, T, du Bois, A, Dürst, M, Easton, D F, Eccles, D M, Edwards, R P, Ekici, A B, Fasching, P A, Fridley, B L, Gentry-Maharaj, A, Giles, G G, Glasspool, R, Goodman, M T, Gronwald, J, Harter, P, Hein, A, Heitz, F, Hildebrandt, M A T, Hillemanns, P, Hogdall, C K, Høgdall, E, Hosono, S, Iversen, E S, Jakubowska, A, Jensen, A, Ji, B-T, Jung, A Y, Karlan, B Y, Kellar, M, Kiemeney, L A, Kiong Lim, B, Kjaer, S K, Krakstad, C, Kupryjanczyk, J, Lambrechts, D, Lambrechts, S, Le, N D, Lele, S, Lester, J, Levine, D A, Li, Z, Liang, D, Lissowska, J, Lu, K, Lubinski, J, Lundvall, L, Massuger, L F A G, Matsuo, K, McGuire, V, McLaughlin, J R, McNeish, I, Menon, U, Milne, R L, Modugno, F, Moysich, K B, Ness, R B, Nevanlinna, H, Odunsi, K, Olson, S H, Orlow, I, Orsulic, S, Paul, J, Pejovic, T, Pelttari, L M, Permuth, J B, Pike, M C, Poole, E M, Rosen, B, Rossing, M A, Rothstein, J H, Runnebaum, I B, Rzepecka, I K, Schernhammer, E, Schwaab, I, Shu, X-O, Shvetsov, Y B, Siddiqui, N, Sieh, W, Song, H, Southey, M C, Spiewankiewicz, B, Sucheston-Campbell, L, Tangen, I L, Teo, S-H, Terry, K L, Thompson, P J, Thomsen, L, Tworoger, S S, van Altena, A M, Vergote, I, Vestrheim Thomsen, L C, Vierkant, R A, Walsh, C S, Wang-Gohrke, S, Wentzensen, N, Whittemore, A S, Wicklund, K G, Wilkens, L R, Woo, Y-L, Wu, A H, Wu, X, Xiang, Y-B, Yang, H, Zheng, W, Ziogas, A, Lee, A W, Pearce, C L, Berchuck, A, Schildkraut, J M, Ramus, S J, Monteiro, A N A, Narod, S A, Sellers, T A, Gayther, S A, Kelemen, L E, Chenevix-Trench, G, Risch, H A, Pharoah, P D P, Goode, E L & Phelan, C M 2018, ' Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility ', PLoS ONE, vol. 13, no. 7, e0197561 . https://doi.org/10.1371/journal.pone.0197561
PLoS ONE, Vol 13, Iss 7, p e0197561 (2018)
Opis pliku :
application/pdf; Electronic-eCollection; text
Tytuł :
Progress in defining the genetic contribution to type 2 diabetes susceptibility
Autorzy :
Morris, Andrew P
Pokaż więcej
Temat :
human activities
Genome-Wide Association Study
Genetic Predisposition to Disease
Diabetes Mellitus, Type 2/genetics
Humans
Genetic Loci
endocrine system diseases
Polymorphism, Single Nucleotide/genetics
Źródło :
Morris, A P 2018, ' Progress in defining the genetic contribution to type 2 diabetes susceptibility ', Current Opinion in Genetics and Development, vol. 50, pp. 41-51 . https://doi.org/10.1016/j.gde.2018.02.003
Current opinion in genetics & development
CURRENT OPINION IN GENETICS & DEVELOPMENT
Opis pliku :
application/vnd.openxmlformats-officedocument.wordprocessingml.document
Tytuł :
Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults.
Autorzy :
Lu, Ling
Bennett, Derrick A.
McCarthy, Mark I.
Bragg, Fiona
Walters, Robin G.
Clarke, Robert
Millwood, Iona Y.
Parish, Sarah
Mahajan, Anubha
Lin, Xu
Guo, Yu
Holmes, Michael V.
Afzal, Shoaib
Nordestgaard, Børge G.
Bian, Zheng
Hill, Michael
Li, Liming
Chen, Zhengming
Pokaż więcej
Temat :
Research Support, Non-U.S. Gov't
Chemical compounds
Vitamin D/analogs & derivatives
Physical Sciences
Geography
Female
Logistic Models
Metabolic Disorders
Risk Factors
Statistics (Mathematics)
Biology and Life Sciences
Physiology
Adipose Tissue
Body Fluids
Cartography
Genotype
Diabetes Mellitus, Type 2/etiology
China/epidemiology
Metabolism
Adult
Male
Statistical Methods
Polymorphism, Single Nucleotide/genetics
Endocrinology
Research Article
Earth Sciences
Anatomy
Mathematics
Vitamin D
Latitude
Geographical Locations
Diabetes Mellitus
Mendelian Randomization Analysis
Mathematical and Statistical Techniques
Catabolism
Endocrine Disorders
Blood Plasma
Biological Tissue
Organic chemistry
People and Places
Europe
Chemistry
Research and Analysis Methods
Aged
Meta-Analysis
Medicine
Middle Aged
Linear Models
Blood
Vitamins
Biochemistry
Europe/epidemiology
Journal Article
Medicine and Health Sciences
Organic compounds
Humans
Źródło :
Lu, L, Bennett, D A, Millwood, I Y, Parish, S, McCarthy, M I, Mahajan, A, Lin, X, Bragg, F, Guo, Y, Holmes, M V, Afzal, S, Nordestgaard, B G, Bian, Z, Hill, M, Walters, R G, Li, L, Chen, Z & Clarke, R 2018, ' Association of vitamin D with risk of type 2 diabetes : A Mendelian randomisation study in European and Chinese adults ', PLoS Medicine, vol. 15, no. 5, e1002566 . https://doi.org/10.1371/journal.pmed.1002566
PLoS Medicine, Vol 15, Iss 5, p e1002566 (2018)
Opis pliku :
application/pdf
Tytuł :
Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors
Autorzy :
Shatwan, Israa M.
Winther, Kristian Hillert
Ellahi, Basma
Elwood, Peter
Ben-Shlomo, Yoav
Givens, Ian
Rayman, Margaret P.
Lovegrove, Julie A.
Vimaleswaran, Karani S.
Pokaż więcej
Temat :
APOE gene
Cholesterol, HDL/blood
Total cholesterol
Research
Caerphilly prospective studies
Triglycerides/blood
PRECISE
Diet
Female
Alleles
Nutritional diseases. Deficiency diseases
Body Mass Index
lipids (amino acids, peptides, and proteins)
LDL-C
Apolipoproteins E/genetics
Middle Aged
Cholesterol, LDL/blood
Genotype
Lipids/blood
Cardiovascular Diseases/blood
Genetic Association Studies
Journal Article
Genetic Predisposition to Disease
RC620-627
Humans
Male
Polymorphism, Single Nucleotide/genetics
Źródło :
Shatwan, I M, Winther, K H, Ellahi, B, Elwood, P, Ben-Shlomo, Y, Givens, I, Rayman, M P, Lovegrove, J A & Vimaleswaran, K S 2018, ' Association of apolipoprotein e gene polymorphisms with blood lipids and their interaction with dietary factors ', Lipids in Health and Disease, vol. 17, no. 1, 98 . https://doi.org/10.1186/s12944-018-0744-2
Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-14 (2018)
Shatwan, I M, Winther, K H, Ellahi, B, Elwood, P, Ben-Shlomo, Y, Givens, I, Rayman, M P, Lovegrove, J A & Vimaleswaran, K S 2018, ' Association of apolipoprotein e gene polymorphisms with blood lipids and their interaction with dietary factors ', Lipids in Health and Disease, vol. 17, 98 . https://doi.org/10.1186/s12944-018-0744-2
Lipids in Health and Disease
Opis pliku :
application/pdf

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