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Wyszukujesz frazę ""Polypyrimidine Tract-Binding Protein"" wg kryterium: Temat


Tytuł :
Identification and Characterization of a Minimal Functional Splicing Regulatory Protein, PTBP1.
Autorzy :
Ontiveros RJ; Department of Biological Sciences, California State University Fullerton, Fullerton, California 92831, United States.
Hernandez L; Department of Biological Sciences, California State University Fullerton, Fullerton, California 92831, United States.
Nguyen H; Department of Chemistry and Biochemistry, California State University Fullerton, Fullerton, California 92831, United States.
Hernandez Lopez AL; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California 90035, United States.
Shankar A; Department of Biological Sciences, California State University Fullerton, Fullerton, California 92831, United States.
Kim E; Department of Biological Sciences, California State University Fullerton, Fullerton, California 92831, United States.
Keppetipola NM; Department of Chemistry and Biochemistry, California State University Fullerton, Fullerton, California 92831, United States.
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Źródło :
Biochemistry [Biochemistry] 2020 Dec 22; Vol. 59 (50), pp. 4766-4774. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Heterogeneous-Nuclear Ribonucleoproteins/*chemistry
Heterogeneous-Nuclear Ribonucleoproteins/*metabolism
Polypyrimidine Tract-Binding Protein/*chemistry
Polypyrimidine Tract-Binding Protein/*metabolism
Alternative Splicing ; Amino Acid Sequence ; Animals ; Calcium Channels, L-Type/genetics ; Cell Line ; Electrophoretic Mobility Shift Assay ; Exons ; Genes, src ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; In Vitro Techniques ; Mice ; Models, Molecular ; Polypyrimidine Tract-Binding Protein/genetics ; Protein Domains ; RNA/genetics ; RNA/metabolism ; RNA Splice Sites ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Deletion
Czasopismo naukowe
Tytuł :
Identification of novel regulators of dendrite arborization using cell type-specific RNA metabolic labeling.
Autorzy :
Aboukilila MY; Department of Molecular and Cell Biology, Quantitative and Systems Biology Graduate Program, University of California, Merced, CA, United States of America.
Sami JD; Department of Molecular and Cell Biology, Quantitative and Systems Biology Graduate Program, University of California, Merced, CA, United States of America.
Wang J; Department of Pharmaceutical Sciences and Department of Chemistry, University of California, Irvine, CA, United States of America.
England W; Department of Pharmaceutical Sciences and Department of Chemistry, University of California, Irvine, CA, United States of America.
Spitale RC; Department of Pharmaceutical Sciences and Department of Chemistry, University of California, Irvine, CA, United States of America.
Cleary MD; Department of Molecular and Cell Biology, Quantitative and Systems Biology Graduate Program, University of California, Merced, CA, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Dec 02; Vol. 15 (12), pp. e0240386. Date of Electronic Publication: 2020 Dec 02 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Developmental*
Dendrites/*physiology
Drosophila Proteins/*metabolism
Neurogenesis/*genetics
Polynucleotide Adenylyltransferase/*metabolism
Polypyrimidine Tract-Binding Protein/*metabolism
Sensory Receptor Cells/*physiology
Animals ; Animals, Genetically Modified ; Cytosine/administration & dosage ; Cytosine/analogs & derivatives ; Cytosine/metabolism ; Deoxyuracil Nucleotides/chemistry ; Deoxyuracil Nucleotides/metabolism ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Drosophila melanogaster/metabolism ; Larva/genetics ; Larva/growth & development ; Larva/metabolism ; Loss of Function Mutation ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Polynucleotide Adenylyltransferase/genetics ; Polypyrimidine Tract-Binding Protein/genetics ; RNA/chemistry ; RNA/metabolism ; RNA Interference ; RNA-Seq ; Sensory Receptor Cells/cytology ; Staining and Labeling/methods
Czasopismo naukowe
Tytuł :
Aberrant Exon 8/8a Splicing by Downregulated PTBP (Polypyrimidine Tract-Binding Protein) 1 Increases Ca V 1.2 Dihydropyridine Resistance to Attenuate Vasodilation.
Autorzy :
Lei J; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Jiangsu, China (J.L., M.S., Y.Z., J.F., G.Z., J.W.).
Liu X; Shanghai Chest Hospital, Shanghai Jiaotong University, China (X.L.).
Song M; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Jiangsu, China (J.L., M.S., Y.Z., J.F., G.Z., J.W.).
Zhou Y; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Jiangsu, China (J.L., M.S., Y.Z., J.F., G.Z., J.W.).
Fan J; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Jiangsu, China (J.L., M.S., Y.Z., J.F., G.Z., J.W.).
Shen X; Department of Cardiovascular Surgery, the First Affiliated Hospital of Nanjing Medical University, Jiangsu, China (X.S., X.X.).
Xu X; Department of Cardiovascular Surgery, the First Affiliated Hospital of Nanjing Medical University, Jiangsu, China (X.S., X.X.).
Kapoor I; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, OH (I.K.).
Zhu G; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Jiangsu, China (J.L., M.S., Y.Z., J.F., G.Z., J.W.).
Wang J; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Jiangsu, China (J.L., M.S., Y.Z., J.F., G.Z., J.W.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Oct; Vol. 40 (10), pp. 2440-2453. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance*
Calcium Channel Blockers/*pharmacology
Calcium Channels, L-Type/*drug effects
Heterogeneous-Nuclear Ribonucleoproteins/*metabolism
Hypertension/*drug therapy
Muscle, Smooth, Vascular/*drug effects
Myocytes, Smooth Muscle/*drug effects
Nifedipine/*pharmacology
Polypyrimidine Tract-Binding Protein/*metabolism
Vasodilation/*drug effects
Vasodilator Agents/*pharmacology
Alternative Splicing ; Animals ; Calcium Channels, L-Type/genetics ; Calcium Channels, L-Type/metabolism ; Cell Line, Tumor ; Disease Models, Animal ; Exons ; HEK293 Cells ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; Humans ; Hypertension/genetics ; Hypertension/metabolism ; Hypertension/physiopathology ; Male ; Membrane Potentials ; Mesenteric Arteries/drug effects ; Mesenteric Arteries/metabolism ; Mesenteric Arteries/physiopathology ; Mice ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/physiopathology ; Myocytes, Smooth Muscle/metabolism ; Polypyrimidine Tract-Binding Protein/genetics ; Rats, Inbred SHR ; Rats, Inbred WKY ; Rats, Sprague-Dawley ; Signal Transduction
Czasopismo naukowe
Tytuł :
The RNA-binding protein PTBP1 promotes ATPase-dependent dissociation of the RNA helicase UPF1 to protect transcripts from nonsense-mediated mRNA decay.
Autorzy :
Fritz SE; Biochemistry and Biophysics Center, NHLBI, National Institutes of Health, Bethesda, Maryland, USA.
Ranganathan S; Biochemistry and Biophysics Center, NHLBI, National Institutes of Health, Bethesda, Maryland, USA.
Wang CD; Biochemistry and Biophysics Center, NHLBI, National Institutes of Health, Bethesda, Maryland, USA.
Hogg JR; Biochemistry and Biophysics Center, NHLBI, National Institutes of Health, Bethesda, Maryland, USA .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Aug 14; Vol. 295 (33), pp. 11613-11625. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Nonsense Mediated mRNA Decay*
Heterogeneous-Nuclear Ribonucleoproteins/*metabolism
Polypyrimidine Tract-Binding Protein/*metabolism
RNA Helicases/*metabolism
Trans-Activators/*metabolism
Adenosine Triphosphate/metabolism ; Heterogeneous-Nuclear Ribonucleoproteins/chemistry ; Humans ; Models, Molecular ; Polypyrimidine Tract-Binding Protein/chemistry ; Protein Domains ; RNA Helicases/chemistry ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Trans-Activators/chemistry ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
PTBP1 Positively Regulates the Translation of Circadian Clock Gene, Period1 .
Autorzy :
Kim W; Division of Cosmetic Science and Technology, Daegu Haany University, Hanuidae-ro 1, Gyeongsan, Gyeongbuk 38610, Korea.
Shin JC; Pohang Technopark, Pohang, Gyeongbuk 790-834, Korea.
Lee KH; Division of Cosmetic Science and Technology, Daegu Haany University, Hanuidae-ro 1, Gyeongsan, Gyeongbuk 38610, Korea.
Kim KT; Department of Life Sciences, Pohang University of Science and Technology, Cheongam-Ro 77, Pohang, Gyeongbuk 37673, Korea.; Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Cheongam-Ro 77, Pohang, Gyeongbuk 37673, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 21; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
5' Untranslated Regions*
Gene Expression Regulation*
Protein Biosynthesis*
Heterogeneous-Nuclear Ribonucleoproteins/*metabolism
Period Circadian Proteins/*biosynthesis
Polypyrimidine Tract-Binding Protein/*metabolism
Animals ; Cryptochromes/biosynthesis ; Cryptochromes/genetics ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; Mice ; NIH 3T3 Cells ; Period Circadian Proteins/genetics ; Polypyrimidine Tract-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
Lnc00462717 regulates the permeability of the blood-brain tumor barrier through interaction with PTBP1 to inhibit the miR-186-5p/Occludin signaling pathway.
Autorzy :
Zhang C; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Zhang X; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Wang J; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Di F; Department of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, P.R. China.
Xue Y; Department of Neurobiology, College Basic of Medicine, China Medical University, Shenyang, P.R. China.
Lin X; Graduate School of Jinzhou Medical University, Jinzhou, P.R. China.
Zhang Y; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Zhang H; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Zhang Z; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Gu Y; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Aug; Vol. 34 (8), pp. 9941-9958. Date of Electronic Publication: 2020 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier/*metabolism
Doxorubicin/*pharmacology
Glioma/*pathology
Heterogeneous-Nuclear Ribonucleoproteins/*metabolism
MicroRNAs/*genetics
Occludin/*metabolism
Polypyrimidine Tract-Binding Protein/*metabolism
RNA, Long Noncoding/*genetics
Animals ; Antibiotics, Antineoplastic/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/pathology ; Brain Neoplasms/drug therapy ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Membrane Permeability ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Glioma/drug therapy ; Glioma/metabolism ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Occludin/genetics ; Polypyrimidine Tract-Binding Protein/genetics ; Rats, Wistar ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
A transient α-helix in the N-terminal RNA recognition motif of polypyrimidine tract binding protein senses RNA secondary structure.
Autorzy :
Maris C; Department of Biology, ETH Zurich, 8093 Zürich, Switzerland.
Jayne S; Department of Biology, ETH Zurich, 8093 Zürich, Switzerland.
Damberger FF; Department of Biology, ETH Zurich, 8093 Zürich, Switzerland.
Beusch I; Department of Biology, ETH Zurich, 8093 Zürich, Switzerland.
Dorn G; Department of Biology, ETH Zurich, 8093 Zürich, Switzerland.
Ravindranathan S; Central NMR facility, National Chemical Laboratory, Pune 411008 India.
Allain FH; Department of Biology, ETH Zurich, 8093 Zürich, Switzerland.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 May 07; Vol. 48 (8), pp. 4521-4537.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Recognition Motif*
Polypyrimidine Tract-Binding Protein/*chemistry
RNA/*chemistry
Encephalomyocarditis virus/genetics ; Internal Ribosome Entry Sites ; Models, Molecular ; Mutation ; Nucleic Acid Conformation ; Polypyrimidine Tract-Binding Protein/genetics ; Polypyrimidine Tract-Binding Protein/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; RNA/metabolism
Czasopismo naukowe
Tytuł :
LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis.
Autorzy :
Liang Y; Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Song X; Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Li Y; Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Chen B; Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Zhao W; Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Wang L; Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Zhang H; Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Liu Y; Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Han D; Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Zhang N; Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Ma T; Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Wang Y; Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Ye F; Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Luo D; Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Li X; Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Yang Q; Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China. .; Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China. .
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Źródło :
Molecular cancer [Mol Cancer] 2020 May 08; Vol. 19 (1), pp. 85. Date of Electronic Publication: 2020 May 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Breast Neoplasms/*pathology
MicroRNAs/*genetics
Polypyrimidine Tract-Binding Protein/*metabolism
RNA, Long Noncoding/*genetics
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Proliferation ; Disease Progression ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Polypyrimidine Tract-Binding Protein/genetics ; Prognosis ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis.
Autorzy :
Zhu W; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhou BL; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Rong LJ; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Ye L; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Xu HJ; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhou Y; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Yan XJ; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Liu WD; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhu B; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Wang L; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Jiang XJ; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Ren CP; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
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Źródło :
Journal of Zhejiang University. Science. B [J Zhejiang Univ Sci B] 2020 Feb.; Vol. 21 (2), pp. 122-136. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alternative Splicing*
Carcinogenesis*
Glycolysis*
Heterogeneous-Nuclear Ribonucleoproteins/*physiology
Polypyrimidine Tract-Binding Protein/*physiology
Heterogeneous-Nuclear Ribonucleoproteins/chemistry ; Humans ; MicroRNAs/physiology ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Polypyrimidine Tract-Binding Protein/chemistry ; RNA, Long Noncoding/physiology
Czasopismo naukowe
Tytuł :
Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5' TOP motifs.
Autorzy :
Philippe L; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510.
van den Elzen AMG; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510.
Watson MJ; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510.
Thoreen CC; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510 .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 10; Vol. 117 (10), pp. 5319-5328. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nucleotide Motifs*
Protein Biosynthesis*
Autoantigens/*metabolism
Polypyrimidine Tract-Binding Protein/*chemistry
Pyrimidines/*chemistry
RNA, Messenger/*chemistry
Ribonucleoproteins/*metabolism
HEK293 Cells ; Humans ; Mechanistic Target of Rapamycin Complex 1/chemistry ; Polypyrimidine Tract-Binding Protein/genetics ; RNA, Messenger/genetics ; Transcriptome
Czasopismo naukowe
Tytuł :
Polypyrimidine tract-binding proteins are essential for B cell development.
Autorzy :
Monzón-Casanova E; Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, United Kingdom.; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Matheson LS; Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, United Kingdom.
Tabbada K; Next Generation Sequencing Facility, The Babraham Institute, Cambridge, United Kingdom.
Zarnack K; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany.
Smith CW; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Turner M; Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, United Kingdom.
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Źródło :
ELife [Elife] 2020 Feb 21; Vol. 9. Date of Electronic Publication: 2020 Feb 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*metabolism
Heterogeneous-Nuclear Ribonucleoproteins/*physiology
Polypyrimidine Tract-Binding Protein/*physiology
Animals ; Cell Cycle ; Cell Differentiation ; Cell Proliferation ; Female ; Flow Cytometry ; Gene Expression Regulation ; Heterogeneous-Nuclear Ribonucleoproteins/metabolism ; Male ; Mice ; Nerve Tissue Proteins/metabolism ; Nerve Tissue Proteins/physiology ; Polypyrimidine Tract-Binding Protein/metabolism ; RNA-Binding Proteins/metabolism ; RNA-Binding Proteins/physiology
Czasopismo naukowe
Tytuł :
Long noncoding RNA HCG22 suppresses proliferation and metastasis of bladder cancer cells by regulation of PTBP1.
Autorzy :
Jiang D; Department of Urology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Zhang Y; Department of Interventional Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Yang L; Department of Radiotherapy for Abdominal Neoplasms, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Lu W; Department of Ultrasound, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Mai L; Department of Gastroenterology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Guo H; Department of Gastroenterology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Liu X; Department of Hepatobiliary Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2020 Feb; Vol. 235 (2), pp. 1711-1722. Date of Electronic Publication: 2019 Jul 15.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Heterogeneous-Nuclear Ribonucleoproteins/*biosynthesis
Polypyrimidine Tract-Binding Protein/*biosynthesis
RNA, Long Noncoding/*genetics
Urinary Bladder Neoplasms/*pathology
Adult ; Aged ; Cell Line, Tumor ; Cell Proliferation/genetics ; ELAV-Like Protein 1/biosynthesis ; ELAV-Like Protein 1/genetics ; Epithelial-Mesenchymal Transition/genetics ; Female ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness/genetics ; Polypyrimidine Tract-Binding Protein/genetics ; Urinary Bladder Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Hypoxia induced LUCAT1/PTBP1 axis modulates cancer cell viability and chemotherapy response.
Autorzy :
Huan L; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Guo T; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Wu Y; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Xu L; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Huang S; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Xu Y; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .
Liang L; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China. .
He X; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China. .
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Źródło :
Molecular cancer [Mol Cancer] 2020 Jan 21; Vol. 19 (1), pp. 11. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Colorectal Neoplasms/*pathology
Heterogeneous-Nuclear Ribonucleoproteins/*metabolism
Hypoxia/*physiopathology
Polypyrimidine Tract-Binding Protein/*metabolism
RNA, Long Noncoding/*genetics
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Female ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Polypyrimidine Tract-Binding Protein/genetics ; Prognosis ; Survival Rate ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Role of polypyrimidine tract-binding protein 1/yin yang 2 signaling in regulating vascular smooth muscle cell proliferation and neointima hyperplasia.
Autorzy :
Wang Z; Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China; Department of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu, Sichuan 610083, China.
Gan X; Department of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu, Sichuan 610083, China.
Qiu C; Department of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu, Sichuan 610083, China.
Yang D; Department of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu, Sichuan 610083, China.
Sun X; Department of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu, Sichuan 610083, China.. Electronic address: .
Zeng Z; Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2019 Nov 15; Vol. 383, pp. 114747. Date of Electronic Publication: 2019 Sep 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation/*physiology
Heterogeneous-Nuclear Ribonucleoproteins/*physiology
Hyperplasia/*metabolism
Muscle, Smooth, Vascular/*metabolism
Neointima/*metabolism
Polypyrimidine Tract-Binding Protein/*physiology
Transcription Factors/*biosynthesis
Animals ; Becaplermin/pharmacology ; Cell Proliferation/drug effects ; Heterogeneous-Nuclear Ribonucleoproteins/antagonists & inhibitors ; Hyperplasia/pathology ; Mice ; Mice, Inbred C57BL ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/pathology ; Neointima/pathology ; Polypyrimidine Tract-Binding Protein/antagonists & inhibitors ; Signal Transduction/drug effects ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
A miR-194/PTBP1/CCND3 axis regulates tumor growth in human hepatocellular carcinoma.
Autorzy :
Kang H; Department of Biochemistry, The Catholic University of Korea, College of Medicine, Seoul, South Korea.; Institute of Aging and Metabolic Diseases, The Catholic University of Korea, College of Medicine, Seoul, South Korea.
Heo S; Department of Molecular Science and Technology, Ajou University, Suwon, South Korea.
Shin JJ; Department of Molecular Science and Technology, Ajou University, Suwon, South Korea.
Ji E; Department of Biochemistry, The Catholic University of Korea, College of Medicine, Seoul, South Korea.
Tak H; Department of Biochemistry, The Catholic University of Korea, College of Medicine, Seoul, South Korea.
Ahn S; Department of Biochemistry, The Catholic University of Korea, College of Medicine, Seoul, South Korea.
Lee KJ; Department of Convergence Medicine, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, South Korea.
Lee EK; Department of Biochemistry, The Catholic University of Korea, College of Medicine, Seoul, South Korea.; Institute of Aging and Metabolic Diseases, The Catholic University of Korea, College of Medicine, Seoul, South Korea.
Kim W; Department of Molecular Science and Technology, Ajou University, Suwon, South Korea.
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Źródło :
The Journal of pathology [J Pathol] 2019 Nov; Vol. 249 (3), pp. 395-408. Date of Electronic Publication: 2019 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
Carcinoma, Hepatocellular/*metabolism
Cyclin D3/*metabolism
Heterogeneous-Nuclear Ribonucleoproteins/*metabolism
Liver Neoplasms/*metabolism
MicroRNAs/*metabolism
Polypyrimidine Tract-Binding Protein/*metabolism
3' Untranslated Regions ; 5' Untranslated Regions ; Animals ; Binding Sites ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cyclin D3/genetics ; Female ; G1 Phase Cell Cycle Checkpoints ; Gene Expression Regulation, Neoplastic ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/genetics ; Polypyrimidine Tract-Binding Protein/genetics ; Signal Transduction ; Tumor Burden ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
PTBP1 enhances exon11a skipping in Mena pre-mRNA to promote migration and invasion in lung carcinoma cells.
Autorzy :
Li S; Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Pharmacodynamics Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of pharmacy, Jinan University, Guangzhou 510632, China.
Shen L; Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Pharmacodynamics Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of pharmacy, Jinan University, Guangzhou 510632, China.
Huang L; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Lei S; Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Pharmacodynamics Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of pharmacy, Jinan University, Guangzhou 510632, China.
Cai X; Department of Respiratory, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Breitzig M; Department of Internal Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, MDC 19, Tampa, FL 33612, USA.
Zhang B; Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Pharmacodynamics Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of pharmacy, Jinan University, Guangzhou 510632, China.
Yang A; Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Pharmacodynamics Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of pharmacy, Jinan University, Guangzhou 510632, China.
Ji W; Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Pharmacodynamics Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of pharmacy, Jinan University, Guangzhou 510632, China.
Huang M; Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Pharmacodynamics Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of pharmacy, Jinan University, Guangzhou 510632, China.
Zheng Q; Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Pharmacodynamics Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of pharmacy, Jinan University, Guangzhou 510632, China.
Sun H; Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Pharmacodynamics Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of pharmacy, Jinan University, Guangzhou 510632, China.
Wang F; Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Pharmacodynamics Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2019 Aug; Vol. 1862 (8), pp. 858-869. Date of Electronic Publication: 2019 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Heterogeneous-Nuclear Ribonucleoproteins/*genetics
Lung Neoplasms/*genetics
Microfilament Proteins/*genetics
Polypyrimidine Tract-Binding Protein/*genetics
A549 Cells ; Cell Movement ; Epithelial-Mesenchymal Transition ; Exons ; Gene Expression Regulation, Neoplastic ; Heterogeneous-Nuclear Ribonucleoproteins/metabolism ; Humans ; Lung Neoplasms/metabolism ; Neoplasm Invasiveness ; Polypyrimidine Tract-Binding Protein/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
PTBP1-targeting microRNAs regulate cancer-specific energy metabolism through the modulation of PKM1/M2 splicing.
Autorzy :
Taniguchi K; Department of General and Gastroenterological Surgery, Osaka Medical College, Osaka, Japan.; Translational Research Program, Osaka Medical College, Osaka, Japan.
Uchiyama K; Department of General and Gastroenterological Surgery, Osaka Medical College, Osaka, Japan.
Akao Y; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Jan; Vol. 112 (1), pp. 41-50. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alternative Splicing/*genetics
Carrier Proteins/*genetics
Energy Metabolism/*genetics
Membrane Proteins/*genetics
MicroRNAs/*genetics
Polypyrimidine Tract-Binding Protein/*genetics
Thyroid Hormones/*genetics
Gene Regulatory Networks/genetics ; Humans ; Pyruvate Kinase/genetics
Czasopismo naukowe
Tytuł :
SINEUP long non-coding RNA acts via PTBP1 and HNRNPK to promote translational initiation assemblies.
Autorzy :
Toki N; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045 Japan.; Functional Genomics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
Takahashi H; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045 Japan.; Functional Genomics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
Sharma H; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045 Japan.
Valentine MNZ; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045 Japan.
Rahman FM; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045 Japan.
Zucchelli S; Department of Health Sciences, Center for Autoimmune and Allergic Diseases (CAAD) and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale, Novara, Italy.
Gustincich S; Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy.
Carninci P; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045 Japan.; Functional Genomics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 18; Vol. 48 (20), pp. 11626-11644.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Chain Initiation, Translational*
Heterogeneous-Nuclear Ribonucleoprotein K/*metabolism
Heterogeneous-Nuclear Ribonucleoproteins/*metabolism
Polypyrimidine Tract-Binding Protein/*metabolism
RNA, Long Noncoding/*metabolism
Cytoplasm/metabolism ; Green Fluorescent Proteins/analysis ; Green Fluorescent Proteins/biosynthesis ; Green Fluorescent Proteins/genetics ; HEK293 Cells ; Humans ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
A protein assembly mediates Xist localization and gene silencing.
Autorzy :
Pandya-Jones A; Department of Biological Chemistry at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Markaki Y; Department of Biological Chemistry at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Department of Biology and Center for Integrated Protein Science, LMU Munich, Munich, Germany.
Serizay J; Department of Biological Chemistry at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; École Normale Supérieure de Cachan, Université Paris-Saclay, Saclay, France.; The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, UK.
Chitiashvili T; Department of Biological Chemistry at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Department of Biology and Center for Integrated Protein Science, LMU Munich, Munich, Germany.
Mancia Leon WR; Department of Biological Chemistry at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Damianov A; Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA.
Chronis C; Department of Biological Chemistry at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA.
Papp B; Department of Biological Chemistry at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA.
Chen CK; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.
McKee R; Department of Biological Chemistry at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Wang XJ; Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA.
Chau A; Department of Biological Chemistry at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Sabri S; Department of Biological Chemistry at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Leonhardt H; Department of Biology and Center for Integrated Protein Science, LMU Munich, Munich, Germany.
Zheng S; Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA.; Division of Biomedical Science, University of California Riverside, Riverside, CA, USA.
Guttman M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Black DL; Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA. .; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA. .; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA. .; Brain Research Institute, University of California Los Angeles, Los Angeles, CA, USA. .; Graduate Program in the Biosciences, University of California Los Angeles, Los Angeles, CA, USA. .
Plath K; Department of Biological Chemistry at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. .; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA. .; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA. .; Brain Research Institute, University of California Los Angeles, Los Angeles, CA, USA. .; Graduate Program in the Biosciences, University of California Los Angeles, Los Angeles, CA, USA. .; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA. .
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Źródło :
Nature [Nature] 2020 Nov; Vol. 587 (7832), pp. 145-151. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Silencing*
RNA, Long Noncoding/*genetics
RNA-Binding Proteins/*metabolism
Animals ; CELF1 Protein/metabolism ; Cell Line ; DNA-Binding Proteins/metabolism ; Female ; Heterogeneous-Nuclear Ribonucleoproteins/metabolism ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Mice ; Nuclear Matrix-Associated Proteins/metabolism ; Polypyrimidine Tract-Binding Protein/metabolism ; X Chromosome Inactivation/genetics
Czasopismo naukowe
Tytuł :
SARS-CoV-2 dysregulation of PTBP1 and YWHAE/Z gene expression: A primer of neurodegeneration.
Autorzy :
Vavougios GD; Department of Neurology, Athens Naval Hospital, P.C. 115 21, Athens, Greece; Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, Biopolis, P.C. 41500 Larissa, Greece; Department of Computer Science and Telecommunications, University of Thessaly, Papasiopoulou 2 - 4, P.C. 35 131 - Galaneika, Lamia, Greece. Electronic address: .
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Źródło :
Medical hypotheses [Med Hypotheses] 2020 Nov; Vol. 144, pp. 110212. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article
MeSH Terms :
14-3-3 Proteins/*genetics
COVID-19/*complications
COVID-19/*genetics
Heterogeneous-Nuclear Ribonucleoproteins/*genetics
Neurodegenerative Diseases/*etiology
Neurodegenerative Diseases/*genetics
Polypyrimidine Tract-Binding Protein/*genetics
COVID-19/virology ; Gene Expression Regulation ; Host Microbial Interactions/genetics ; Humans ; Models, Neurological ; Nerve Degeneration/etiology ; Nerve Degeneration/genetics ; Pandemics ; SARS-CoV-2/pathogenicity
Czasopismo naukowe

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