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    Wyświetlanie 1-7 z 7
    Tytuł:
    PPAR-Gamma Orchestrates EMT, AGE, and Cellular Senescence Pathways in Colonic Epithelium and Restrains the Progression of IBDs.
    Autorzy:
    Pompili S; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
    Vetuschi A; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
    Latella G; Department of Life, Health, and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
    Smakaj A; Department of Geriatrics and Ortopaedic Sciences, University Cattolica del Sacro Cuore, 00168 Rome, Italy.
    Sferra R; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
    Cappariello A; Department of Life, Health, and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2023 May 18; Vol. 24 (10). Date of Electronic Publication: 2023 May 18.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Colitis*/chemically induced
    Colitis*/drug therapy
    Colitis*/metabolism
    Inflammatory Bowel Diseases*/drug therapy
    Inflammatory Bowel Diseases*/pathology
    Humans ; Mice ; Animals ; PPAR gamma/metabolism ; Epithelial-Mesenchymal Transition ; Colon/pathology ; Epithelium/metabolism ; Dextran Sulfate/toxicity ; Mice, Inbred C57BL
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Prolonged Chronic Consumption of a High Fat with Sucrose Diet Alters the Morphology of the Small Intestine.
    Autorzy:
    Sferra R; Department of Biotechnological and Applied Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
    Pompili S; Department of Biotechnological and Applied Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
    Cappariello A; Department of Biotechnological and Applied Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
    Gaudio E; Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy.
    Latella G; Department of Life, Health and Environmental Sciences, Division of Gastroenterology, Hepatology, and Nutrition, University of L'Aquila, 67100 L'Aquila, Italy.
    Vetuschi A; Department of Biotechnological and Applied Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2021 Jul 06; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 06.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Diet, High-Fat/*adverse effects
    Dietary Sucrose/*administration & dosage
    Dietary Sucrose/*adverse effects
    Intestinal Mucosa/*pathology
    Intestine, Small/*pathology
    Adiponectin/metabolism ; Animals ; Feeding Behavior/physiology ; Intestinal Mucosa/metabolism ; Intestine, Small/metabolism ; Leptin/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/metabolism ; Obesity/pathology ; PPAR gamma/metabolism ; Receptors, Leptin/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Dual CXCR4 and E-Selectin Inhibitor, GMI-1359, Shows Anti-Bone Metastatic Effects and Synergizes with Docetaxel in Prostate Cancer Cell Intraosseous Growth.
    Autorzy:
    Festuccia C; Department of Biotechnological and Applied Clinical Sciences, laboratory of Radiobiology, University of L'Aquila, 67100 L'Aquila, Italy.
    Mancini A; Department of Biotechnological and Applied Clinical Sciences, laboratory of Radiobiology, University of L'Aquila, 67100 L'Aquila, Italy.; Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital, IRCCS, Viale di San Paolo 15, 00146 Rome, Italy.
    Gravina GL; Department of Biotechnological and Applied Clinical Sciences, laboratory of Radiobiology, University of L'Aquila, 67100 L'Aquila, Italy.; Department of Biotechnological and Applied Clinical Sciences, Division of Radiation Oncology, University of L'Aquila, 67100 L'Aquila, Italy.
    Colapietro A; Department of Biotechnological and Applied Clinical Sciences, laboratory of Radiobiology, University of L'Aquila, 67100 L'Aquila, Italy.
    Vetuschi A; Department of Biotechnological and Applied Clinical Sciences, Laboratory of Human Anatomy, University of L'Aquila, 67100 L'Aquila, Italy.
    Pompili S; Department of Biotechnological and Applied Clinical Sciences, Laboratory of Human Anatomy, University of L'Aquila, 67100 L'Aquila, Italy.
    Ventura L; Pathology Department, San Salvatore Hospital, L'Aquila 67100, Italy.
    Delle Monache S; Department of Biotechnological and Applied Clinical Sciences, Laboratory of Applied Biology, University of L'Aquila, 67100 L'Aquila, Italy.
    Iorio R; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila 67100, Italy.
    Del Fattore A; Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital, IRCCS, Viale di San Paolo 15, 00146 Rome, Italy.
    Fogler W; GlycoMimetics Inc. Gaithersburg, MD 20850, USA.
    Magnani J; GlycoMimetics Inc. Gaithersburg, MD 20850, USA.
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    Źródło:
    Cells [Cells] 2019 Dec 20; Vol. 9 (1). Date of Electronic Publication: 2019 Dec 20.
    Typ publikacji:
    Comparative Study; Journal Article
    MeSH Terms:
    Bone Neoplasms/*drug therapy
    Bone Neoplasms/*secondary
    Docetaxel/*administration & dosage
    Prostatic Neoplasms, Castration-Resistant/*drug therapy
    Small Molecule Libraries/*administration & dosage
    Animals ; Bone Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Docetaxel/pharmacology ; Drug Synergism ; E-Selectin/antagonists & inhibitors ; Glycolipids/administration & dosage ; Glycolipids/pharmacology ; Humans ; Male ; Mice ; PC-3 Cells ; Peptides/administration & dosage ; Peptides/pharmacology ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Receptors, CXCR4/antagonists & inhibitors ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Xenograft Model Antitumor Assays
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The Brain Penetrating and Dual TORC1/TORC2 Inhibitor, RES529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine Models.
    Autorzy:
    Gravina GL; Department of Biotechnological and Applied Clinical Sciences, Division of Radiation Oncology, University of L'Aquila, 67100 L'Aquila, Italy. .
    Mancini A; Department of Biotechnological and Applied Clinical Sciences, Laboratory of Radiobiology, University of L'Aquila, 67100 L'Aquila, Italy. mancio_.
    Colapietro A; Department of Biotechnological and Applied Clinical Sciences, Laboratory of Radiobiology, University of L'Aquila, 67100 L'Aquila, Italy. .
    Delle Monache S; Department of Biotechnological and Applied Clinical Sciences, Laboratory of Cellular Biology, University of L'Aquila, 67100 L'Aquila, Italy. simona..
    Sferra R; Department of Biotechnological and Applied Clinical Sciences, Laboratory of Human Anatomy, University of L'Aquila, 67100 L'Aquila, Italy. .
    Pompili S; Department of Biotechnological and Applied Clinical Sciences, Laboratory of Human Anatomy, University of L'Aquila, 67100 L'Aquila, Italy. pompili.simona@virgilio.it.
    Vitale F; Department of Biotechnological and Applied Clinical Sciences, Laboratory of Neurophysiology, University of L'Aquila, 67100 L'Aquila, Italy. .
    Martellucci S; Department of Biotechnological and Applied Clinical Sciences, Laboratory of Cellular Biology, University of L'Aquila, 67100 L'Aquila, Italy. .; Laboratory of Experimental Medicine and Environmental Pathology, University Hub 'Sabina Universitas', 02100 Rieti, Italy. .
    Marampon F; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, 00118 Rome, Italy. .
    Mattei V; Laboratory of Experimental Medicine and Environmental Pathology, University Hub 'Sabina Universitas', 02100 Rieti, Italy. .
    Biordi L; Department of Biotechnological and Applied Clinical Sciences, Laboratory of Experimental Oncology, University of L'Aquila, 67100 L'Aquila, Italy. .
    Sherris D; Sherris Pharma Partners, Jamaica Plain, MA 02130, USA. .
    Festuccia C; Department of Biotechnological and Applied Clinical Sciences, Division of Radiation Oncology, University of L'Aquila, 67100 L'Aquila, Italy. .
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    Źródło:
    Cancers [Cancers (Basel)] 2019 Oct 21; Vol. 11 (10). Date of Electronic Publication: 2019 Oct 21.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Can Nrf2 Modulate the Development of Intestinal Fibrosis and Cancer in Inflammatory Bowel Disease?
    Autorzy:
    Pompili S; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
    Sferra R; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
    Gaudio E; Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Sapienza University of Rome, 00185 Rome, Italy.
    Viscido A; Department of Life, Health and Environmental Sciences, Gastroenterology, Hepatology and Nutrition Division, University of L'Aquila, 67100 L'Aquila, Italy.
    Frieri G; Department of Life, Health and Environmental Sciences, Gastroenterology, Hepatology and Nutrition Division, University of L'Aquila, 67100 L'Aquila, Italy.
    Vetuschi A; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
    Latella G; Department of Life, Health and Environmental Sciences, Gastroenterology, Hepatology and Nutrition Division, University of L'Aquila, 67100 L'Aquila, Italy. .
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2019 Aug 20; Vol. 20 (16). Date of Electronic Publication: 2019 Aug 20.
    Typ publikacji:
    Journal Article; Review
    MeSH Terms:
    Colorectal Neoplasms/*metabolism
    Inflammation/*metabolism
    NF-E2-Related Factor 2/*metabolism
    Animals ; Fibrosis/metabolism ; Humans ; Inflammatory Bowel Diseases/metabolism ; Oxidative Stress/physiology ; Signal Transduction/physiology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma.
    Autorzy:
    Festuccia C; Laboratory of Radiobiology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, L'Aquila, Italy. .
    Mancini A; Laboratory of Radiobiology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, L'Aquila, Italy.
    Colapietro A; Laboratory of Radiobiology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, L'Aquila, Italy.
    Gravina GL; Laboratory of Radiobiology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, L'Aquila, Italy.; Division of Radiotherapy, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, L'Aquila, Italy.
    Vitale F; Division of Neurosciences, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, L'Aquila, Italy.
    Marampon F; Division of Radiotherapy, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, L'Aquila, Italy.
    Delle Monache S; Division of Applied Biology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, L'Aquila, Italy.
    Pompili S; Division of Human Anatomy, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, L'Aquila, Italy.
    Cristiano L; Laboratory of Applied Biology, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
    Vetuschi A; Division of Human Anatomy, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, L'Aquila, Italy.
    Tombolini V; Division of Radiotherapy, Department of Experimental Medicine, University of Rome 'La Sapienza', Rome, Italy.
    Chen Y; Northlake International LLC, Pleasanton, CA, USA.
    Mehrling T; Mundipharma-EDO GmbH, Basel, Switzerland.
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    Źródło:
    Journal of hematology & oncology [J Hematol Oncol] 2018 Feb 27; Vol. 11 (1), pp. 32. Date of Electronic Publication: 2018 Feb 27.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents, Alkylating/*therapeutic use
    Benzimidazoles/*therapeutic use
    Brain Neoplasms/*drug therapy
    Brain Neoplasms/*radiotherapy
    Glioblastoma/*drug therapy
    Glioblastoma/*radiotherapy
    Histone Deacetylase Inhibitors/*therapeutic use
    Animals ; Antineoplastic Agents, Alkylating/pharmacology ; Bendamustine Hydrochloride/pharmacology ; Bendamustine Hydrochloride/therapeutic use ; Benzimidazoles/pharmacology ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Female ; Glioblastoma/pathology ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Mice ; Vorinostat/pharmacology ; Vorinostat/therapeutic use
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Role of glycogen synthase kinase-3β and PPAR-γ on epithelial-to-mesenchymal transition in DSS-induced colorectal fibrosis.
    Autorzy:
    Di Gregorio J; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
    Sferra R; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
    Speca S; University of Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France.; IBD, Lille, France.
    Vetuschi A; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
    Dubuquoy C; IBD, Lille, France.
    Desreumaux P; University of Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France.; IBD, Lille, France.; CHR Lille, Service des Maladies de l'Appareil Digestif et de la Nutrition, Hôpital Claude Huriez, Lille, France.
    Pompili S; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
    Cristiano L; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
    Gaudio E; Department of Human Anatomy, University of Rome La Sapienza, Rome, Italy.
    Flati V; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
    Latella G; Department of Life, Health and Environmental Sciences, Gastroenterology Unit, University of L'Aquila, L'Aquila, Italy.
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    Źródło:
    PloS one [PLoS One] 2017 Feb 16; Vol. 12 (2), pp. e0171093. Date of Electronic Publication: 2017 Feb 16 (Print Publication: 2017).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Epithelial-Mesenchymal Transition*
    Colitis/*pathology
    Dextran Sulfate/*toxicity
    Fibrosis/*pathology
    Glycogen Synthase Kinase 3 beta/*metabolism
    PPAR gamma/*metabolism
    Rectum/*pathology
    Animals ; Cells, Cultured ; Colitis/chemically induced ; Colitis/metabolism ; Fibrosis/chemically induced ; Fibrosis/metabolism ; Glycogen Synthase Kinase 3 beta/genetics ; Mice ; Mice, Inbred C57BL ; PPAR gamma/genetics ; Rectum/drug effects ; Rectum/metabolism ; Signal Transduction ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-7 z 7

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