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Tytuł:
From the identification of actionable molecular targets to the generation of faithful neuroblastoma patient-derived preclinical models.
Autorzy:
Capasso M; Department of Medical Biotechnology, University of Naples Federico II, 80138, Naples, Italy.; CEINGE Advanced Biotecnology, 80138, Naples, Italy.
Brignole C; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Lasorsa VA; CEINGE Advanced Biotecnology, 80138, Naples, Italy.
Bensa V; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Cantalupo S; Department of Medical Biotechnology, University of Naples Federico II, 80138, Naples, Italy.; CEINGE Advanced Biotecnology, 80138, Naples, Italy.
Sebastiani E; CIBIO, University of Trento, 38122, Trento, Italy.
Quattrone A; CIBIO, University of Trento, 38122, Trento, Italy.
Ciampi E; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Avitabile M; Department of Medical Biotechnology, University of Naples Federico II, 80138, Naples, Italy.; CEINGE Advanced Biotecnology, 80138, Naples, Italy.
Sementa AR; Pathological Anatomy, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy.
Mazzocco K; Pathological Anatomy, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy.
Cafferata B; Pathological Anatomy, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy.
Gaggero G; Pathological Anatomy, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy.
Vellone VG; Pathological Anatomy, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy.
Cilli M; Animal Facility, IRCCS Policlinico San Martino, 16100, Genoa, Italy.
Calarco E; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Giusto E; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Perri P; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Aveic S; Pediatric Research Institute Città Della Speranza, 35127, Padua, Italy.
Fruci D; Department of Emato-Oncology, Bambino Gesù Children's Hospital, 00146, -Rome, Italy.
Tondo A; Department of Emato-Oncology, Anna Meyer Children's Hospital, 50139, Florence, Italy.
Luksch R; Emato-Oncology Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, 20133, Milan, Italy.
Mura R; Emato-Oncology Unit, Azienda Ospedaliera Brotzu, 09047, Cagliari, Italy.
Rabusin M; Pediatric Department, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137, Trieste, Italy.
De Leonardis F; Department of Pediatric Oncology, Polyclinic Hospital, 70124, Bari, Italy.
Cellini M; Emato-Oncology Unit, University-Hospital Polyclinic of Modena, 41124, Modena, Italy.
Coccia P; University-Hospital of Marche, Presidio Ospedaliero 'G. Salesi', 60126, Ancona, Italy.
Iolascon A; Department of Medical Biotechnology, University of Naples Federico II, 80138, Naples, Italy.; CEINGE Advanced Biotecnology, 80138, Naples, Italy.
Corrias MV; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Conte M; Clinical Oncology Unit, IRCCS Istituto Giannina Gaslini, 16147, -Genoa, Italy.
Garaventa A; Clinical Oncology Unit, IRCCS Istituto Giannina Gaslini, 16147, -Genoa, Italy.
Amoroso L; Clinical Oncology Unit, IRCCS Istituto Giannina Gaslini, 16147, -Genoa, Italy.
Ponzoni M; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy. .
Pastorino F; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
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Źródło:
Journal of translational medicine [J Transl Med] 2024 Feb 13; Vol. 22 (1), pp. 151. Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Copy Number Variations*
Neuroblastoma*/genetics
Neuroblastoma*/drug therapy
Neuroblastoma*/pathology
Infant ; Humans ; Animals ; Mice ; Neoplasm Recurrence, Local ; Disease Models, Animal ; Flow Cytometry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma.
Autorzy:
Lucarini V; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy.
Melaiu O; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy.; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy.
D'Amico S; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy.
Pastorino F; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy.
Tempora P; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy.
Scarsella M; Flow Cytometry Core Facility, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy.
Pezzullo M; Research Laboratories, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy.
De Ninno A; CNR Institute for Photonics and Nanotechnology, Rome, 00156, Italy.
D'Oria V; Confocal Microscopy Core Facility, Research Center, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy.
Cilli M; IRCCS Ospedale Policlinico San Martino, Animal Facility, 16132, Genoa, Italy.
Emionite L; IRCCS Ospedale Policlinico San Martino, Animal Facility, 16132, Genoa, Italy.
Infante P; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.
Di Marcotullio L; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.
De Ioris MA; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy.
Barillari G; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy.
Alaggio R; Pathology Unit, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy.
Businaro L; CNR Institute for Photonics and Nanotechnology, Rome, 00156, Italy.
Ponzoni M; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy.
Locatelli F; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy.; Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, 00168, Rome, Italy.
Fruci D; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2022 Nov 17; Vol. 41 (1), pp. 326. Date of Electronic Publication: 2022 Nov 17.
Typ publikacji:
Journal Article
MeSH Terms:
Programmed Cell Death 1 Receptor*
Neuroblastoma*/drug therapy
Humans ; Mice ; Animals ; Mitoxantrone/pharmacology ; CD8-Positive T-Lymphocytes ; Transforming Growth Factor beta ; Cell Line, Tumor ; Mice, Transgenic ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Italian Precision Medicine in Pediatric Oncology: Moving beyond Actionable Alterations.
Autorzy:
Pastorino F; Laboratorio di Terapie Sperimentali in Oncologia, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Capasso M; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy.; CEINGE Biotecnologie Avanzate, 80131 Napoli, Italy.
Brignole C; Laboratorio di Terapie Sperimentali in Oncologia, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Giglio S; UOC Oncologia, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Bensa V; Laboratorio di Terapie Sperimentali in Oncologia, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Cantalupo S; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy.; CEINGE Biotecnologie Avanzate, 80131 Napoli, Italy.
Lasorsa VA; CEINGE Biotecnologie Avanzate, 80131 Napoli, Italy.
Tondo A; Dipartimento di Oncoematologia, Ospedale Meyer, 50139 Firenze, Italy.
Mura R; Oncoematologia Pediatrica, Ospedale Pediatrico Microcitemico 'Antonio Cao' Azienda Ospedaliera Brotzu, 09121 Cagliari, Italy.
Sementa AR; Dipartimento di Patologia, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Garaventa A; UOC Oncologia, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Ponzoni M; Laboratorio di Terapie Sperimentali in Oncologia, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Amoroso L; UOC Oncologia, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 23; Vol. 23 (19). Date of Electronic Publication: 2022 Sep 23.
Typ publikacji:
Case Reports
MeSH Terms:
Neuroblastoma*
Precision Medicine*/methods
Adult ; Child ; Child, Preschool ; Cullin Proteins/genetics ; Humans ; Male ; Medical Oncology ; Mutation ; Neoplasm Recurrence, Local/genetics ; Exome Sequencing/methods ; Young Adult
Raport
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Recent advances in the developmental origin of neuroblastoma: an overview.
Autorzy:
Ponzoni M; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Bachetti T; U.O. Proteomica e Spettrometria di Massa, IRCSS Ospedale Policlinico San Martino, Genoa, Italy.
Corrias MV; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Brignole C; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Pastorino F; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Calarco E; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Bensa V; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Giusto E; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.
Ceccherini I; Laboratory of Genetics and Genomics of Rare Diseases, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Perri P; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2022 Mar 11; Vol. 41 (1), pp. 92. Date of Electronic Publication: 2022 Mar 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neuroblastoma/*embryology
Transcription Factors/*metabolism
Animals ; Cell Differentiation ; Humans ; Mice ; Neuroblastoma/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cell surface Nucleolin represents a novel cellular target for neuroblastoma therapy.
Autorzy:
Brignole C; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Bensa V; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Fonseca NA; CNC - Center for Neurosciences and Cell Biology, Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Faculty of Medicine (Polo 1), Coimbra, Portugal.; TREAT U, SA - Parque Industrial de Taveiro, Lote 44, 3045-508, Coimbra, Portugal.
Del Zotto G; Department of Research and Diagnostics, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Bruno S; Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Cruz AF; CNC - Center for Neurosciences and Cell Biology, Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Faculty of Medicine (Polo 1), Coimbra, Portugal.; UC - University of Coimbra, CIBB, Faculty of Pharmacy, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.
Malaguti F; Department of Pathology, Istituto Giannina Gaslini, Genoa, Italy.
Carlini B; Department of Pathology, Istituto Giannina Gaslini, Genoa, Italy.
Morandi F; Stem Cell Laboratory and Cell Therapy Center, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Calarco E; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Perri P; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Moura V; CNC - Center for Neurosciences and Cell Biology, Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Faculty of Medicine (Polo 1), Coimbra, Portugal.; TREAT U, SA - Parque Industrial de Taveiro, Lote 44, 3045-508, Coimbra, Portugal.
Emionite L; Animal Facility, IRCSS Ospedale Policlinico San Martino, Genoa, Italy.
Cilli M; Animal Facility, IRCSS Ospedale Policlinico San Martino, Genoa, Italy.
De Leonardis F; Department of Pediatric Oncology, Azienda Ospedale Policlinico di Bari, Bari, Italy.
Tondo A; UOC Oncologia Pediatrica, Ospedale Meyer, Florence, Italy.
Amoroso L; UOC Oncologia, IRCCS Istituto Gaslini, Genoa, Italy.
Conte M; UOC Oncologia, IRCCS Istituto Gaslini, Genoa, Italy.
Garaventa A; UOC Oncologia, IRCCS Istituto Gaslini, Genoa, Italy.
Sementa AR; Department of Pathology, Istituto Giannina Gaslini, Genoa, Italy.
Corrias MV; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Ponzoni M; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Genoa, Italy. .
Moreira JN; CNC - Center for Neurosciences and Cell Biology, Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Faculty of Medicine (Polo 1), Coimbra, Portugal.; UC - University of Coimbra, CIBB, Faculty of Pharmacy, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.
Pastorino F; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Genoa, Italy. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2021 Jun 02; Vol. 40 (1), pp. 180. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Proliferation/*drug effects
Doxorubicin/*pharmacology
Neuroblastoma/*drug therapy
Phosphoproteins/*genetics
RNA-Binding Proteins/*genetics
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Bone Marrow Cells/drug effects ; Cell Line, Tumor ; Cell Membrane/genetics ; Cell Survival/drug effects ; Doxorubicin/chemistry ; Heterografts ; Humans ; Liposomes/chemistry ; Liposomes/pharmacology ; Mice ; Nanoparticles/chemistry ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Peptides/chemistry ; Peptides/genetics ; Peptides/pharmacology ; Nucleolin
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Autophagic flux inhibition enhances cytotoxicity of the receptor tyrosine kinase inhibitor ponatinib.
Autorzy:
Corallo D; Neuroblastoma Laboratory, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Corso Stati Uniti 4, 35121, Padova, Italy. .
Pastorino F; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto G Gaslini, Genoa, Italy.
Pantile M; Neuroblastoma Laboratory, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Corso Stati Uniti 4, 35121, Padova, Italy.
Mariotto E; Department of Woman's and Child's Health, University of Padova, Padova, Italy.
Caicci F; Department of Biology, University of Padova, Padova, Italy.
Viola G; Department of Woman's and Child's Health, University of Padova, Padova, Italy.
Ponzoni M; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto G Gaslini, Genoa, Italy.
Tonini GP; Neuroblastoma Laboratory, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Corso Stati Uniti 4, 35121, Padova, Italy.
Aveic S; Neuroblastoma Laboratory, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Corso Stati Uniti 4, 35121, Padova, Italy. .; Department of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Aachen, Germany. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2020 Sep 22; Vol. 39 (1), pp. 195. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Proliferation/*drug effects
Imidazoles/*pharmacology
Neuroblastoma/*drug therapy
Pyridazines/*pharmacology
Receptor Protein-Tyrosine Kinases/*genetics
Animals ; Apoptosis/drug effects ; Autophagy/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Chloroquine/pharmacology ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Lysosomes/drug effects ; Mice ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Protein Kinase Inhibitors/pharmacology ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma.
Autorzy:
Morandi F; Stem Cell Laboratory and Cell Therapy Center, IRCCS Istituto Giannina Gaslini, 16148 Genova, Italy.
Frassoni F; Stem Cell Laboratory and Cell Therapy Center, IRCCS Istituto Giannina Gaslini, 16148 Genova, Italy.
Ponzoni M; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16148 Genova, Italy.
Brignole C; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16148 Genova, Italy.
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Źródło:
Journal of immunology research [J Immunol Res] 2018 Oct 30; Vol. 2018, pp. 8097398. Date of Electronic Publication: 2018 Oct 30 (Print Publication: 2018).
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Immunotherapy/*methods
Melanoma/*therapy
Neural Crest/*pathology
Neuroblastoma/*therapy
Adult ; Animals ; Child ; Clinical Trials as Topic ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Humans ; Melanoma/immunology ; Melanoma/pathology ; Neuroblastoma/immunology ; Neuroblastoma/pathology ; Remission Induction ; Translational Research, Biomedical
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PHOX2B-mediated regulation of ALK expression: in vitro identification of a functional relationship between two genes involved in neuroblastoma.
Autorzy:
Bachetti T; Laboratory of Molecular Genetics, G. Gaslini Children's Hospital, Genoa, Italy.
Di Paolo D
Di Lascio S
Mirisola V
Brignole C
Bellotti M
Caffa I
Ferraris C
Fiore M
Fornasari D
Chiarle R
Borghini S
Pfeffer U
Ponzoni M
Ceccherini I
Perri P
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Źródło:
PloS one [PLoS One] 2010 Oct 01; Vol. 5 (10). Date of Electronic Publication: 2010 Oct 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic/*physiology
Homeodomain Proteins/*physiology
Neuroblastoma/*genetics
Protein-Tyrosine Kinases/*genetics
Transcription Factors/*physiology
Anaplastic Lymphoma Kinase ; Cell Line, Tumor ; Gene Silencing ; Homeodomain Proteins/genetics ; Humans ; In Vitro Techniques ; Neuroblastoma/pathology ; RNA, Small Interfering ; Receptor Protein-Tyrosine Kinases ; Regulatory Sequences, Nucleic Acid ; Transcription Factors/genetics ; Transcriptional Activation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells.
Autorzy:
Pisano M; Istituto di Chimica Biomolecolare, CNR, Sassari, Italy.
Pagnan G
Dettori MA
Cossu S
Caffa I
Sassu I
Emionite L
Fabbri D
Cilli M
Pastorino F
Palmieri G
Delogu G
Ponzoni M
Rozzo C
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Źródło:
Molecular cancer [Mol Cancer] 2010 Jun 03; Vol. 9, pp. 137. Date of Electronic Publication: 2010 Jun 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Curcumin/*pharmacology
Melanoma/*pathology
Neuroblastoma/*pathology
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; Humans ; In Situ Nick-End Labeling ; Mice ; Mice, Nude ; Transplantation, Heterologous
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Synergistic inhibition of human neuroblastoma-related angiogenesis by vinblastine and rapamycin.
Autorzy:
Marimpietri D; Differentiation Therapy Unit Laboratory of Oncology, G Gaslini Childrens' Hospital, Genoa 16148, and Department of Human Anatomy and Histology, University of Bari Medical School, Italy.
Nico B
Vacca A
Mangieri D
Catarsi P
Ponzoni M
Ribatti D
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Źródło:
Oncogene [Oncogene] 2005 Oct 13; Vol. 24 (45), pp. 6785-95.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents, Phytogenic/*pharmacology
Neovascularization, Pathologic/*prevention & control
Neuroblastoma/*blood supply
Sirolimus/*pharmacology
Vinblastine/*pharmacology
Animals ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Culture Media, Conditioned ; Drug Synergism ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Female ; Humans ; In Situ Nick-End Labeling ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Neuroblastoma/drug therapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Expression and methylation of CASP8 in neuroblastoma: identification of a promoter region.
Autorzy:
Banelli B
Casciano I
Croce M
Di Vinci A
Gelvi I
Pagnan G
Brignole C
Allemanni G
Ferrini S
Ponzoni M
Romani M
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Źródło:
Nature medicine [Nat Med] 2002 Dec; Vol. 8 (12), pp. 1333-5; author reply 1335.
Typ publikacji:
Comment; Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
CpG Islands*
DNA Methylation*
Promoter Regions, Genetic*
Caspases/*genetics
Neuroblastoma/*genetics
Caspase 8 ; Caspase 9 ; Humans ; Tumor Cells, Cultured
Raport
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Expression of DeltaNp73 is a molecular marker for adverse outcome in neuroblastoma patients.
Autorzy:
Casciano I; Laboratory of Population Genetics, Istituto Nazionale per la Ricerca sul Cancro (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy.
Mazzocco K
Boni L
Pagnan G
Banelli B
Allemanni G
Ponzoni M
Tonini GP
Romani M
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Źródło:
Cell death and differentiation [Cell Death Differ] 2002 Mar; Vol. 9 (3), pp. 246-51.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*physiology
Neuroblastoma/*diagnosis
Child ; Child, Preschool ; DNA-Binding Proteins/biosynthesis ; DNA-Binding Proteins/genetics ; Genes, Tumor Suppressor ; Humans ; Infant ; Infant, Newborn ; Neuroblastoma/mortality ; Nuclear Proteins/biosynthesis ; Nuclear Proteins/genetics ; Prognosis ; Protein Isoforms/biosynthesis ; Protein Isoforms/genetics ; Survival Rate ; Tumor Protein p73 ; Tumor Suppressor Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Different p73 splicing variants are expressed in distinct tumour areas of a multifocal neuroblastoma.
Autorzy:
Casciano I
Ponzoni M
Lo Cunsolo C
Tonini GP
Romani M
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Źródło:
Cell death and differentiation [Cell Death Differ] 1999 May; Vol. 6 (5), pp. 391-3.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Alternative Splicing*
Apoptosis*
Genes, Tumor Suppressor*
Genetic Variation*
DNA-Binding Proteins/*genetics
Neuroblastoma/*genetics
Nuclear Proteins/*genetics
Humans ; Neuroblastoma/pathology ; Tumor Protein p73 ; Tumor Suppressor Proteins
Raport
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