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    Wyświetlanie 1-13 z 13
    Tytuł:
    Optimized phylogenetic clustering of HIV-1 sequence data for public health applications.
    Autorzy:
    Chato C; Department of Pathology and Laboratory Medicine, Western University, London, Canada.
    Feng Y; Division of Virology and Immunology, National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China-CDC), Beijing, China.
    Ruan Y; Division of Virology and Immunology, National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China-CDC), Beijing, China.
    Xing H; Division of Virology and Immunology, National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China-CDC), Beijing, China.
    Herbeck J; Department of Global Health, University of Washington, Seattle, Washington, United States of America.
    Kalish M; Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.
    Poon AFY; Department of Pathology and Laboratory Medicine, Western University, London, Canada.
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2022 Nov 30; Vol. 18 (11), pp. e1010745. Date of Electronic Publication: 2022 Nov 30 (Print Publication: 2022).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    HIV-1*/genetics
    HIV Infections*/epidemiology
    Humans ; Phylogeny ; Prospective Studies ; Public Health ; Cluster Analysis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    First-line HIV treatment failures in non-B subtypes and recombinants: a cross-sectional analysis of multiple populations in Uganda.
    Autorzy:
    Poon AFY; Department of Pathology and Laboratory Medicine, Health Sciences Addition, H422, Western University, London, ON, N6G 2R5, Canada. .; Department of Microbiology and Immunology, Western University, London, Canada. .; Department of Applied Mathematics, Western University, London, Canada. .
    Ndashimye E; Department of Microbiology and Immunology, Western University, London, Canada.; Joint Clinical Research Centre, Kampala, Uganda.
    Avino M; Department of Pathology and Laboratory Medicine, Health Sciences Addition, H422, Western University, London, ON, N6G 2R5, Canada.
    Gibson R; Department of Microbiology and Immunology, Western University, London, Canada.
    Kityo C; Joint Clinical Research Centre, Kampala, Uganda.
    Kyeyune F; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA.
    Nankya I; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.; Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
    Quiñones-Mateu ME; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.; Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.
    Arts EJ; Department of Microbiology and Immunology, Western University, London, Canada.; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.
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    Corporate Authors:
    The Ugandan Drug Resistance Study Team
    Źródło:
    AIDS research and therapy [AIDS Res Ther] 2019 Jan 22; Vol. 16 (1), pp. 3. Date of Electronic Publication: 2019 Jan 22.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Recombination, Genetic*
    Anti-Retroviral Agents/*therapeutic use
    HIV Infections/*drug therapy
    HIV-1/*drug effects
    HIV-1/*genetics
    Adolescent ; Adult ; Bayes Theorem ; Cohort Studies ; Cross-Sectional Studies ; Drug Resistance, Viral ; Female ; Genotype ; HIV Infections/virology ; HIV Seropositivity ; HIV-1/classification ; Humans ; Male ; Sequence Analysis, DNA ; Treatment Failure ; Uganda ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Quantitation of the latent HIV-1 reservoir from the sequence diversity in viral outgrowth assays.
    Autorzy:
    Poon AFY; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada. .
    Prodger JL; Department of Microbiology and Immunology, Western University, London, ON, Canada.; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
    Lynch BA; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD, USA.
    Lai J; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
    Reynolds SJ; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Rakai Health Sciences Program, Kalisizo, Uganda.
    Kasule J; Rakai Health Sciences Program, Kalisizo, Uganda.
    Capoferri AA; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
    Lamers SL; BioInfoExperts, LLC, Thibodaux, LA, USA.
    Rodriguez CW; BioInfoExperts, LLC, Thibodaux, LA, USA.
    Bruno D; Genomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
    Porcella SF; Genomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
    Martens C; Genomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
    Quinn TC; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD, USA.; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
    Redd AD; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD, USA.; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
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    Źródło:
    Retrovirology [Retrovirology] 2018 Jul 05; Vol. 15 (1), pp. 47. Date of Electronic Publication: 2018 Jul 05.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genetic Variation*
    Genome, Viral*
    Viral Load*
    Virus Latency*
    HIV Infections/*virology
    HIV-1/*physiology
    Bayes Theorem ; CD4-Positive T-Lymphocytes/virology ; Computer Simulation ; Disease Reservoirs ; Humans ; Virus Activation ; Virus Replication
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Higher sequence diversity in the vaginal tract than in blood at early HIV-1 infection.
    Autorzy:
    Klein K; Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
    Nickel G; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
    Nankya I; Joint Clinical Research Centre, Kampala, Uganda.
    Kyeyune F; Joint Clinical Research Centre, Kampala, Uganda.
    Demers K; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.; Joint Clinical Research Centre, Kampala, Uganda.
    Ndashimye E; Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.; Joint Clinical Research Centre, Kampala, Uganda.
    Kwok C; FHI 360, Durham, North Carolina, United States of America.
    Chen PL; FHI 360, Durham, North Carolina, United States of America.
    Rwambuya S; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.; Joint Clinical Research Centre, Kampala, Uganda.
    Poon A; Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada.
    Munjoma M; Department of Obstetrics and Gynaecology, University of Zimbabwe, Harare, Zimbabwe.
    Chipato T; Department of Obstetrics and Gynaecology, University of Zimbabwe, Harare, Zimbabwe.
    Byamugisha J; Faculty of Medicine, Makerere University, Kampala, Uganda.
    Mugyenyi P; Joint Clinical Research Centre, Kampala, Uganda.
    Salata RA; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
    Morrison CS; FHI 360, Durham, North Carolina, United States of America.
    Arts EJ; Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.; Joint Clinical Research Centre, Kampala, Uganda.
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    Źródło:
    PLoS pathogens [PLoS Pathog] 2018 Jan 18; Vol. 14 (1), pp. e1006754. Date of Electronic Publication: 2018 Jan 18 (Print Publication: 2018).
    Typ publikacji:
    Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
    MeSH Terms:
    Genetic Variation*
    Cervix Uteri/*virology
    HIV Infections/*virology
    HIV Seropositivity/*virology
    HIV-1/*genetics
    Vagina/*virology
    Viremia/*virology
    Base Sequence ; Cohort Studies ; Female ; HIV Seropositivity/blood ; HIV-1/isolation & purification ; High-Throughput Nucleotide Sequencing ; Humans ; Longitudinal Studies ; RNA, Viral/blood ; RNA, Viral/chemistry ; RNA, Viral/isolation & purification ; Reproductive Tract Infections/blood ; Reproductive Tract Infections/virology ; Uganda ; Viral Load ; Viremia/blood ; Zimbabwe ; env Gene Products, Human Immunodeficiency Virus/chemistry ; env Gene Products, Human Immunodeficiency Virus/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Sensitive detection of HIV-1 resistance to Zidovudine and impact on treatment outcomes in low- to middle-income countries.
    Autorzy:
    Gibson RM; Department of Microbiology and Immunology, University of Western Ontario, 1151 Richmond St., Dental Sciences Bldg., Rm 3014, London, Ontario, N6A 5C1, Canada.
    Nickel G; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
    Crawford M; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
    Kyeyune F; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.
    Venner C; Department of Microbiology and Immunology, University of Western Ontario, 1151 Richmond St., Dental Sciences Bldg., Rm 3014, London, Ontario, N6A 5C1, Canada.
    Nankya I; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA.; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.; Department of Pathology and Laboratory Medicine, University of Western Ontario, Kampala, Uganda.
    Nabulime E; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.
    Ndashimye E; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.
    Poon AFY; Department of Pathology and Laboratory Medicine, University of Western Ontario, Kampala, Uganda.
    Salata RA; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
    Kityo C; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.
    Mugyenyi P; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.
    Quiñones-Mateu ME; Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.; Center for AIDS Research Uganda Laboratories, Joint Clinical Research Centre, Kampala, Uganda.
    Arts EJ; Department of Microbiology and Immunology, University of Western Ontario, 1151 Richmond St., Dental Sciences Bldg., Rm 3014, London, Ontario, N6A 5C1, Canada. .; TREAT, Joint Clinical Research Centre, Kampala, Uganda. .
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    Źródło:
    Infectious diseases of poverty [Infect Dis Poverty] 2017 Dec 04; Vol. 6 (1), pp. 163. Date of Electronic Publication: 2017 Dec 04.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Drug Resistance, Viral*
    Treatment Outcome*
    Anti-HIV Agents/*therapeutic use
    HIV Infections/*drug therapy
    HIV-1/*drug effects
    Zidovudine/*therapeutic use
    Adolescent ; Adult ; Anti-HIV Agents/pharmacology ; CD4 Lymphocyte Count ; Child ; Child, Preschool ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Treatment Failure ; Uganda ; Viral Load ; Young Adult ; Zidovudine/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    "Deep" sequencing accuracy and reproducibility using Roche/454 technology for inferring co-receptor usage in HIV-1.
    Autorzy:
    Knapp DJ; BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
    McGovern RA; BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
    Poon AF; BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
    Zhong X; BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
    Chan D; BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
    Swenson LC; BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
    Dong W; BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
    Harrigan PR; BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada; Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
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    Źródło:
    PloS one [PLoS One] 2014 Jun 24; Vol. 9 (6), pp. e99508. Date of Electronic Publication: 2014 Jun 24 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    HIV Infections/*virology
    HIV-1/*genetics
    High-Throughput Nucleotide Sequencing/*methods
    Sequence Analysis, RNA/*methods
    Humans ; Reproducibility of Results
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic.
    Autorzy:
    Cotton LA; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
    Kuang XT; Department of Molecular Biology and Biochemistry, Faculty of Science, Simon Fraser University, Burnaby, British Columbia, Canada.
    Le AQ; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
    Carlson JM; Microsoft Research, Los Angeles, California, United States of America.
    Chan B; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
    Chopera DR; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.
    Brumme CJ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
    Markle TJ; Department of Molecular Biology and Biochemistry, Faculty of Science, Simon Fraser University, Burnaby, British Columbia, Canada.
    Martin E; Department of Molecular Biology and Biochemistry, Faculty of Science, Simon Fraser University, Burnaby, British Columbia, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
    Shahid A; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
    Anmole G; Department of Molecular Biology and Biochemistry, Faculty of Science, Simon Fraser University, Burnaby, British Columbia, Canada.
    Mwimanzi P; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
    Nassab P; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
    Penney KA; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
    Rahman MA; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
    Milloy MJ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
    Schechter MT; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
    Markowitz M; Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America.
    Carrington M; Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America; Ragon Institute of MGH, MIT and Harvard University, Cambridge, Massachusetts, United States of America.
    Walker BD; Ragon Institute of MGH, MIT and Harvard University, Cambridge, Massachusetts, United States of America.
    Wagner T; San Francisco Department of Public Health, San Francisco, California, United States of America.
    Buchbinder S; San Francisco Department of Public Health, San Francisco, California, United States of America.
    Fuchs J; San Francisco Department of Public Health, San Francisco, California, United States of America.
    Koblin B; New York Blood Center, New York, New York, United States of America.
    Mayer KH; Fenway Community Health, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts, United States of America.
    Harrigan PR; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
    Brockman MA; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada; Department of Molecular Biology and Biochemistry, Faculty of Science, Simon Fraser University, Burnaby, British Columbia, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
    Poon AF; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
    Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
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    Źródło:
    PLoS genetics [PLoS Genet] 2014 Apr 24; Vol. 10 (4), pp. e1004295. Date of Electronic Publication: 2014 Apr 24 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Adaptation, Physiological/*genetics
    HIV Infections/*genetics
    HIV-1/*genetics
    Amino Acid Sequence ; Genotype ; HLA Antigens/genetics ; Humans ; Male ; Molecular Sequence Data ; North America ; Phylogeny ; Polymorphism, Genetic/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Reconstructing the dynamics of HIV evolution within hosts from serial deep sequence data.
    Autorzy:
    Poon AF; BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada. />Swenson LC
    Bunnik EM
    Edo-Matas D
    Schuitemaker H
    van 't Wout AB
    Harrigan PR
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2012; Vol. 8 (11), pp. e1002753. Date of Electronic Publication: 2012 Nov 01.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Evolution, Molecular*
    High-Throughput Nucleotide Sequencing*
    Computational Biology/*methods
    HIV Infections/*virology
    HIV-1/*genetics
    Host-Pathogen Interactions/*genetics
    Algorithms ; Amino Acid Sequence ; Genetic Fitness/genetics ; Genotype ; HIV-1/pathogenicity ; Humans ; Molecular Sequence Data ; Mutation ; Phenotype ; Phylogeny ; RNA, Viral/chemistry ; RNA, Viral/genetics ; Receptors, CCR5 ; Receptors, CXCR4
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    HIV-1 nef protein structures associated with brain infection and dementia pathogenesis.
    Autorzy:
    Lamers SL; Polytechnic Institute of New York University, New York, New York, United States of America.
    Poon AF
    McGrath MS
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    Źródło:
    PloS one [PLoS One] 2011 Feb 09; Vol. 6 (2), pp. e16659. Date of Electronic Publication: 2011 Feb 09.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Brain/*virology
    Dementia/*virology
    HIV Infections/*complications
    HIV-1/*metabolism
    HIV-1/*pathogenicity
    nef Gene Products, Human Immunodeficiency Virus/*chemistry
    nef Gene Products, Human Immunodeficiency Virus/*metabolism
    Amino Acid Sequence ; Consensus Sequence ; Models, Molecular ; Molecular Sequence Data ; Organ Specificity ; Phylogeny ; Point Mutation ; Protein Structure, Tertiary ; Sequence Alignment ; Structure-Activity Relationship ; nef Gene Products, Human Immunodeficiency Virus/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-13 z 13

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