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Tytuł:
β-COP Suppresses the Surface Expression of the TREK2.
Autorzy:
Kim SS; School of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Republic of Korea.
Park J; School of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Republic of Korea.; BK21FOUR R&E Center for Learning Health Systems, Korea University, Seoul 02841, Republic of Korea.
Kim E; Brain Science Institute (BSI), Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Hwang EM; Brain Science Institute (BSI), Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Park JY; School of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Republic of Korea.; BK21FOUR R&E Center for Learning Health Systems, Korea University, Seoul 02841, Republic of Korea.; ASTRION, Inc., Seoul 02842, Republic of Korea.
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Źródło:
Cells [Cells] 2023 May 29; Vol. 12 (11). Date of Electronic Publication: 2023 May 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Potassium Channels, Tandem Pore Domain*/metabolism
Coatomer Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluation of the Ion Channel Assembly in a Eukaryotic Cell-Free System Focusing on Two-Pore Domain Potassium Channels K 2P .
Autorzy:
Ullrich J; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Branch Bioanalytics and Bioprocesses (IZI-BB), Am Mühlenberg 13, 14476 Potsdam, Germany.; Institute of Biotechnology, Technische Universität Berlin, Straße des 17. Juni 135, 10623 Berlin, Germany.
Ohlhoff C; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Branch Bioanalytics and Bioprocesses (IZI-BB), Am Mühlenberg 13, 14476 Potsdam, Germany.; Institute of Biotechnology, Technische Universität Berlin, Straße des 17. Juni 135, 10623 Berlin, Germany.
Dondapati SK; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Branch Bioanalytics and Bioprocesses (IZI-BB), Am Mühlenberg 13, 14476 Potsdam, Germany.
Zemella A; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Branch Bioanalytics and Bioprocesses (IZI-BB), Am Mühlenberg 13, 14476 Potsdam, Germany.
Kubick S; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Branch Bioanalytics and Bioprocesses (IZI-BB), Am Mühlenberg 13, 14476 Potsdam, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Thielallee 63, 14195 Berlin, Germany.; Faculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology Cottbus-Senftenberg, the Brandenburg Medical School Theodor Fontane and the University of Potsdam, 14476 Potsdam, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 27; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 27.
Typ publikacji:
Journal Article
MeSH Terms:
Eukaryota*/metabolism
Potassium Channels, Tandem Pore Domain*/genetics
Potassium Channels, Tandem Pore Domain*/metabolism
Cell-Free System/metabolism ; Dimerization ; Biological Assay
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Advances in the Understanding of Two-Pore Domain TASK Potassium Channels and Their Potential as Therapeutic Targets.
Autorzy:
Fan X; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.; Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang 550002, China.
Lu Y; Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510700, China.
Du G; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Liu J; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Nov 28; Vol. 27 (23). Date of Electronic Publication: 2022 Nov 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Potassium Channels, Tandem Pore Domain*/genetics
Potassium Channels, Tandem Pore Domain*/chemistry
Humans ; Membrane Potentials ; Potassium/metabolism ; Action Potentials ; Arrhythmias, Cardiac
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier.
Autorzy:
Kanda H; School of Pharmacy, Hyogo Medical University, Kobe, Hyogo, 650-8530, Japan. .; Laboratory of Basic Pain Research, Hyogo Medical University, Kobe, Hyogo, 650-8530, Japan. .
Noguchi K; Laboratory of Basic Pain Research, Hyogo Medical University, Kobe, Hyogo, 650-8530, Japan.
Dai Y; School of Pharmacy, Hyogo Medical University, Kobe, Hyogo, 650-8530, Japan.; Laboratory of Basic Pain Research, Hyogo Medical University, Kobe, Hyogo, 650-8530, Japan.; Department of Anatomy and Neuroscience, Hyogo Medical University, Nishinomiya, Hyogo, 663-8501, Japan.
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Źródło:
Molecular brain [Mol Brain] 2023 Jan 17; Vol. 16 (1), pp. 8. Date of Electronic Publication: 2023 Jan 17.
Typ publikacji:
Journal Article
MeSH Terms:
Potassium Channels, Tandem Pore Domain*/physiology
Stress, Mechanical*
Animals ; Rats ; Action Potentials/physiology ; Arachidonic Acid ; Axons ; Neurons/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Subcellular Localization of Homomeric TASK3 Channels and Its Presumed Functional Significances in Trigeminal Motoneurons.
Autorzy:
Saito M; Department of Oral Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
Tanaka C; Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Suita 565-0871, Japan.
Toyoda H; Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Suita 565-0871, Japan.
Kang Y; Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Suita 565-0871, Japan.; Department of Behavioral Sciences, Osaka University Graduate School of Human Sciences, Suita 565-0871, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 25; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 25.
Typ publikacji:
Journal Article
MeSH Terms:
Motor Neurons*/metabolism
Potassium Channels, Tandem Pore Domain*/metabolism
Humans ; HEK293 Cells ; Nerve Tissue Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
β-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes.
Autorzy:
Kim SS; School of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea.
Bae Y; School of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea.; Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.
Kwon O; School of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea.
Kwon SH; Seoul Center, Korea Basic Science Institute (KBSI), Seoul 02841, Korea.
Seo JB; Seoul Center, Korea Basic Science Institute (KBSI), Seoul 02841, Korea.
Hwang EM; Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.
Park JY; School of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea.
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Źródło:
Cells [Cells] 2022 Oct 21; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Astrocytes*/metabolism
Potassium Channels, Tandem Pore Domain*
Animals ; Mice ; Brain/metabolism ; Cell Membrane/metabolism ; Coatomer Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Potassium Channels as Therapeutic Targets in Pulmonary Arterial Hypertension.
Autorzy:
Redel-Traub G; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Sampson KJ; Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Kass RS; Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Bohnen MS; Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
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Źródło:
Biomolecules [Biomolecules] 2022 Sep 22; Vol. 12 (10). Date of Electronic Publication: 2022 Sep 22.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Potassium Channels, Tandem Pore Domain*/genetics
Pulmonary Arterial Hypertension*
Channelopathies*/drug therapy
Channelopathies*/genetics
Hypertension, Pulmonary*/drug therapy
Hypertension, Pulmonary*/genetics
Hypertension, Pulmonary*/pathology
Potassium Channels, Voltage-Gated*
Humans ; Endothelin-1 ; Nerve Tissue Proteins/metabolism ; Familial Primary Pulmonary Hypertension/genetics ; Prostaglandins I ; Potassium ; KATP Channels/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Gain and loss of TASK3 channel function and its regulation by novel variation cause KCNK9 imprinting syndrome.
Autorzy:
Cousin MA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
Veale EL; Medway School of Pharmacy, University of Kent and University of Greenwich, Central Avenue, Anson Building, Central Avenue, Chatham Maritime, ME4 4, Kent, TB, ME4 4 TB, UK.
Dsouza NR; Bioinformatics Research and Development Laboratory, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Tripathi S; Bioinformatics Research and Development Laboratory, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Holden RG; Medway School of Pharmacy, University of Kent and University of Greenwich, Central Avenue, Anson Building, Central Avenue, Chatham Maritime, ME4 4, Kent, TB, ME4 4 TB, UK.
Arelin M; Department for Women and Child Health, Hospital for Children and Adolescents, University Hospitals, University of Leipzig, Leipzig, Germany.
Beek G; Children's Hospital of Minnesota, Minneapolis, MN, USA.
Bekheirnia MR; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Beygo J; Institute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Bhambhani V; Children's Hospital of Minnesota, Minneapolis, MN, USA.
Bialer M; Division of Medical Genetics, Northwell Health, Manhasset, NY, USA.
Bigoni S; Medical Genetics Unit, Department of Medical Sciences, Ferrara University, Ferrara, Italy.
Boelman C; Division of Neurology, BC Children's Hospital, Vancouver, British Columbia, Canada.
Carmichael J; Oxford Centre for Genomic Medicine, ACE Building, Nuffield Orthopaedic centre, Oxford University Hospitals NHS Foundation Trust, Windmill road, Headington, Oxford, OX3 7HE, UK.
Courtin T; Département of Genetics, APHP, Hôpital Pitié-Salpêtrière, Sorbonne Université, Paris, France.
Cogne B; CHU Nantes, Service de génétique médicale, Nantes, France.
Dabaj I; CHU de Rouen, Service de Néonatologie, Réanimation pédiatrique, Neuropédiatrie et éducation fonctionnelle de l'enfant, INSERM U 1245, ED497, 76000, Rouen, France.; APHP, Hôpital Raymond Poincaré, Hôpitaux Universitaires Paris Ile-de-France Ouest, Pôle pédiatrique, Service de Pédiatrie, Centre de Reference Nord-Est-Ile de France, 92380, Garches, France.
Doummar D; APHP, Department of Neuropediatrics, National Reference Center for Neurogenetic Disorders, Hôpital Armand-Trousseau, GHUEP, Paris, France.
Fazilleau L; Service de Néonatologie, CHU de Caen, Caen, France.
Ferlini A; Medical Genetics Unit, Department of Medical Sciences, Ferrara University, Ferrara, Italy.
Gavrilova RH; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA.
Graham JM Jr; Department of Pediatrics, Harbor-UCLA Medical Center, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Haack TB; Centre for Rare Diseases, University of Tübingen, Tübingen, Germany.; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
Juusola J; GeneDx, 207 Perry Parkway, Gaithersburg, MD, USA.
Kant SG; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Kayani S; Departments of Pediatrics and Neurology, University of Texas Southwestern Medical Center and Children's Health, Dallas, TX, USA.
Keren B; APHP, Département de Génétique et Centre de Référence Déficiences Intellectuelles de Causes Rares, Hôpital de la Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris, 75651, Paris, France.
Ketteler P; Institute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; Pediatrics III, Pediatric Oncology and Hematology, University Hospital Essen, Essen, Germany.
Klöckner C; Institute of Human Genetics, University of Leipzig Medical Center, 04103, Leipzig, Germany.
Koopmann TT; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Kruisselbrink TM; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA.
Kuechler A; Institute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Lambert L; Service de Genetique Clinique, CHRU de Nancy, F-54000, Vandoeuvre-les-Nancy, France.; Unite INSERM N-GERE UMR_S 1256, Université de Lorraine, Faculté de Médecine, 9 avenue de la Forêt de Haye, CS 50184, Vandoeuvre-les-Nancy, France.
Latypova X; CHU Nantes, Service de génétique médicale, Nantes, France.
Lebel RR; Section of Medical Genetics, SUNY Upstate University Hospital, Syracuse, NY, USA.
Leduc MS; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Leonardi E; Molecular Genetics of Neurodevelopmental Disorders, Department of Woman and Child Health, University of Padova, Padua, Italy.; Pediatric Research Institute, Città della Speranza, Padova, Italy.
Lewis AM; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Liew W; Department of Paediatric Medicine, KK Women's and Children's Hospital, Mount Elizabeth Hospital, Singapore, Singapore.
Machol K; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.
Mardini S; Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, MN, USA.
McWalter K; GeneDx, 207 Perry Parkway, Gaithersburg, MD, USA.
Mignot C; APHP, Département de Génétique et Centre de Référence Déficiences Intellectuelles de Causes Rares, Hôpital de la Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris, 75651, Paris, France.
McLaughlin J; Division of Medical Genetics, Northwell Health, Manhasset, NY, USA.
Murgia A; Molecular Genetics of Neurodevelopmental Disorders, Department of Woman and Child Health, University of Padova, Padua, Italy.; Pediatric Research Institute, Città della Speranza, Padova, Italy.
Narayanan V; Center for Rare Childhood Disorders, Translational Genomics Research Institute, Phoenix, AZ, USA.
Nava C; APHP, Département de Génétique et Centre de Référence Déficiences Intellectuelles de Causes Rares, Hôpital de la Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris, 75651, Paris, France.
Neuser S; Institute of Human Genetics, University of Leipzig Medical Center, 04103, Leipzig, Germany.
Nizon M; CHU Nantes, Service de génétique médicale, Nantes, France.
Ognibene D; Medical Genetics Unit, Department of Medical Sciences, Ferrara University, Ferrara, Italy.
Park J; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
Platzer K; Institute of Human Genetics, University of Leipzig Medical Center, 04103, Leipzig, Germany.
Poirsier C; Department of Genetics, Reims University Hospital, Reims, France.
Radtke M; Institute of Human Genetics, University of Leipzig Medical Center, 04103, Leipzig, Germany.
Ramsey K; Center for Rare Childhood Disorders, Translational Genomics Research Institute, Phoenix, AZ, USA.
Runke CK; Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA.
Guillen Sacoto MJ; GeneDx, 207 Perry Parkway, Gaithersburg, MD, USA.
Scaglia F; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.; Joint BCM-CUHK Center of Medical Genetics, Shatin, Hong Kong SAR.
Shinawi M; Department of Pediatrics, Division of Genetics and Genomic Medicine, Washington University School of Medicine, St. Louis, MT, USA.
Spranger S; Practice of Human Genetics, Bremen, Germany.
Tan ES; Department of Paediatric Medicine, KK Women's and Children's Hospital, Mount Elizabeth Hospital, Singapore, Singapore.
Taylor J; Oxford Centre for Genomic Medicine, ACE Building, Nuffield Orthopaedic centre, Oxford University Hospitals NHS Foundation Trust, Windmill road, Headington, Oxford, OX3 7HE, UK.
Trentesaux AS; Service de Néonatologie, CHU de Caen, Caen, France.
Vairo F; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA.
Willaert R; GeneDx, 207 Perry Parkway, Gaithersburg, MD, USA.
Zadeh N; Genetics Center, Orange, CA, USA.; Division of Medical Genetics, CHOC Children's Hospital, Orange, CA, USA.
Urrutia R; Bioinformatics Research and Development Laboratory, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.; Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Babovic-Vuksanovic D; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA.
Zimmermann MT; Bioinformatics Research and Development Laboratory, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. .; Clinical and Translational Sciences Institute, Medical College of Wisconsin, Human Research Center, Milwaukee, Wl, USA. .; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA. .
Mathie A; Medway School of Pharmacy, University of Kent and University of Greenwich, Central Avenue, Anson Building, Central Avenue, Chatham Maritime, ME4 4, Kent, TB, ME4 4 TB, UK. .; School of Engineering, Arts, Science and Technology, University of Suffolk, Ipswich, UK. .
Klee EW; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA. .; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA. .; Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA. .
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Źródło:
Genome medicine [Genome Med] 2022 Jun 13; Vol. 14 (1), pp. 62. Date of Electronic Publication: 2022 Jun 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Intellectual Disability*/genetics
Potassium Channels, Tandem Pore Domain*/genetics
Potassium Channels, Tandem Pore Domain*/metabolism
Genotype ; Humans ; Muscle Hypotonia ; Mutation ; Phenotype
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Epigenomic Analysis Reveals the KCNK9 Potassium Channel as a Potential Therapeutic Target for Adenomyosis.
Autorzy:
Chu LH; Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Liao CC; Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Nuwa Fertility Center, Taipei 106467, Taiwan.
Liew PL; Department of Pathology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Chen CW; Dr Wang Reproductive Fertility Center, Taipei 110007, Taiwan.
Su PH; Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Translational Epigenetics Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Wen KC; Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Lai HC; Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Translational Epigenetics Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, National Defense Medical Center, Taipei 11490, Taiwan.
Huang RL; Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Translational Epigenetics Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Chen LY; Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Translational Epigenetics Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 May 26; Vol. 23 (11). Date of Electronic Publication: 2022 May 26.
Typ publikacji:
Journal Article
MeSH Terms:
Adenomyosis*/genetics
Adenomyosis*/metabolism
Adenomyosis*/pathology
Endometriosis*/pathology
Infertility*/metabolism
Potassium Channels, Tandem Pore Domain*/metabolism
Dysmenorrhea/genetics ; Endometrium/metabolism ; Epigenomics ; Female ; Humans ; Potassium Channels/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Channelopathy Genes in Pulmonary Arterial Hypertension.
Autorzy:
Welch CL; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Chung WK; Department of Pediatrics, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
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Źródło:
Biomolecules [Biomolecules] 2022 Feb 07; Vol. 12 (2). Date of Electronic Publication: 2022 Feb 07.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms:
Channelopathies*
Potassium Channels, Tandem Pore Domain*/genetics
Pulmonary Arterial Hypertension*/genetics
Adenosine Triphosphatases/genetics ; Adult ; Child ; Humans ; Membrane Transport Proteins/genetics ; Mutation ; Nerve Tissue Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Two-Pore-Domain Potassium (K 2P -) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes.
Autorzy:
Wiedmann F; Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, University of Heidelberg, 69120 Heidelberg, Germany.; HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, 69120 Heidelberg, Germany.
Frey N; Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, University of Heidelberg, 69120 Heidelberg, Germany.; HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, 69120 Heidelberg, Germany.
Schmidt C; Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, University of Heidelberg, 69120 Heidelberg, Germany.; HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, 69120 Heidelberg, Germany.
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Źródło:
Cells [Cells] 2021 Oct 27; Vol. 10 (11). Date of Electronic Publication: 2021 Oct 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Atrial Remodeling*
Cardiovascular Diseases/*metabolism
Cardiovascular Diseases/*physiopathology
Myocardium/*metabolism
Potassium Channels, Tandem Pore Domain/*metabolism
Animals ; Cardiovascular Diseases/genetics ; Gene Expression Regulation ; Humans ; Potassium Channels, Tandem Pore Domain/chemistry ; Potassium Channels, Tandem Pore Domain/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
5-(Indol-2-yl)pyrazolo[3,4- b ]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis.
Autorzy:
Ramírez D; Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Llano Subercaseaux 2801-Piso 5, Santiago 8900000, Chile.
Mejia-Gutierrez M; Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, A.A, Cali 760031, Colombia.
Insuasty B; Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, A.A, Cali 760031, Colombia.
Rinné S; Institute for Physiology and Pathophysiology, Vegetative Physiology and Center for Mind, Brain and Behavior (CMBB), Philipps-University of Marburg, Deutschhausstraße 2, 35037 Marburg, Germany.
Kiper AK; Institute for Physiology and Pathophysiology, Vegetative Physiology and Center for Mind, Brain and Behavior (CMBB), Philipps-University of Marburg, Deutschhausstraße 2, 35037 Marburg, Germany.
Platzk M; Joint Pulmonary Drug Discovery Lab Bayer-MGH, Boston, MA 02114, USA.
Müller T; Bayer AG, Research & Development, Pharmaceuticals, D-42096 Wuppertal, Germany.
Decher N; Institute for Physiology and Pathophysiology, Vegetative Physiology and Center for Mind, Brain and Behavior (CMBB), Philipps-University of Marburg, Deutschhausstraße 2, 35037 Marburg, Germany.
Quiroga J; Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, A.A, Cali 760031, Colombia.
De-la-Torre P; Department of Otolaryngology, Harvard Medical School and Massachusetts Eye and Ear, 243 Charles St, Boston, MA 02114, USA.; Caribe Therapeutics, Vía 40 No. 69-111, Oficina 804 A, Barranquilla 080002, Colombia.
González W; Centro de Bioinformática, Simulación y Modelado (CBSM), Facultad de Ingeniería, Universidad de Talca, Poniente No. 1141, Talca 3460000, Chile.; Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Talca, Talca 3460000, Chile.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 25; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 25.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Docking Simulation*
Potassium Channel Blockers*/chemical synthesis
Potassium Channel Blockers*/chemistry
Potassium Channels, Tandem Pore Domain*/antagonists & inhibitors
Potassium Channels, Tandem Pore Domain*/chemistry
Pyridines*/chemical synthesis
Pyridines*/chemistry
Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Quercetin relieves D-amphetamine-induced manic-like behaviour through activating TREK-1 potassium channels in mice.
Autorzy:
Ren K; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.; College of Life Sciences and Research Center for Resource Peptide Drugs, Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, Yanan University, Yanan, China.
Liu H; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Guo B; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Li R; Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Mao H; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Xue Q; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Yao H; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Wu S; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Bai Z; College of Life Sciences and Research Center for Resource Peptide Drugs, Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, Yanan University, Yanan, China.
Wang W; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2021 Sep; Vol. 178 (18), pp. 3682-3695. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Potassium Channels, Tandem Pore Domain*
Quercetin*/pharmacology
Animals ; Dextroamphetamine ; HEK293 Cells ; Humans ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Muscimol Directly Activates the TREK-2 Channel Expressed in GABAergic Neurons through Its N-Terminus.
Autorzy:
Kim EJ; Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea.
Kwon OS; Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea.
Hur CG; Cronex Co., Jeju 63078, Korea.
Nyiramana MM; Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea.
Lee DK; Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea.
Hong SG; Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea.
Han J; Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea.
Kang D; Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 27; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 27.
Typ publikacji:
Journal Article
MeSH Terms:
Membrane Potentials*
GABA-A Receptor Agonists/*pharmacology
GABAergic Neurons/*metabolism
Muscimol/*pharmacology
Potassium Channels, Tandem Pore Domain/*metabolism
Receptors, GABA/*chemistry
Animals ; Cells, Cultured ; GABAergic Neurons/drug effects ; HEK293 Cells ; Humans ; Male ; Mice ; Potassium Channels, Tandem Pore Domain/genetics ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
TRESK background potassium channel modifies the TRPV1-mediated nociceptor excitability in sensory neurons.
Autorzy:
Lengyel M; Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Hajdu D; Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Dobolyi A; Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Rosta J; Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Czirják G; Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Dux M; Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Enyedi P; Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
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Źródło:
Cephalalgia : an international journal of headache [Cephalalgia] 2021 Jun; Vol. 41 (7), pp. 827-838. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Migraine Disorders*
Potassium Channels, Tandem Pore Domain*
TRPV Cation Channels*/genetics
Nociceptors/*metabolism
Sensory Receptor Cells/*metabolism
Animals ; Calcitonin Gene-Related Peptide/metabolism ; Capsaicin ; Humans ; Mice ; Potassium Channels
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models.
Autorzy:
West JD; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Austin ED; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Rizzi EM; Division of Allergy and Immunology, Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Yan L; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Tanjore H; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Crabtree AL; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Moore CS; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Muthian G; Department of Cancer Biology, Biochemistry and Neuropharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.
Carrier EJ; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jacobson DA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Hamid R; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Kendall PL; Division of Allergy and Immunology, Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Majka S; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO 80206, USA.
Rathinasabapathy A; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 May 09; Vol. 22 (9). Date of Electronic Publication: 2021 May 09.
Typ publikacji:
Journal Article
MeSH Terms:
Mutation*
Immunomodulation/*genetics
Nerve Tissue Proteins/*genetics
Potassium Channels, Tandem Pore Domain/*genetics
Pulmonary Arterial Hypertension/*genetics
Pulmonary Arterial Hypertension/*immunology
Animals ; Biomarkers ; Case-Control Studies ; Cytokines/metabolism ; Disease Models, Animal ; Disease Susceptibility ; Gene Expression Profiling ; Genetic Predisposition to Disease ; Humans ; Hypoxia/genetics ; Hypoxia/metabolism ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Mice ; Mice, Knockout ; Models, Biological ; Monocytes/immunology ; Monocytes/metabolism ; Nerve Tissue Proteins/metabolism ; Potassium Channels, Tandem Pore Domain/metabolism ; Pulmonary Arterial Hypertension/complications ; Pulmonary Arterial Hypertension/physiopathology ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Circadian photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling.
Autorzy:
Giannoni-Guzmán MA; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Kamitakahara A; Department of Pediatrics and Program in Developmental Neuroscience and Neurogenetics, Keck School of Medicine, The Saban Research Institute, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.
Magalong V; Department of Pediatrics and Program in Developmental Neuroscience and Neurogenetics, Keck School of Medicine, The Saban Research Institute, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.
Levitt P; Department of Pediatrics and Program in Developmental Neuroscience and Neurogenetics, Keck School of Medicine, The Saban Research Institute, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.
McMahon DG; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
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Źródło:
Journal of pineal research [J Pineal Res] 2021 Mar; Vol. 70 (2), pp. e12705. Date of Electronic Publication: 2020 Dec 12.
Typ publikacji:
Journal Article
MeSH Terms:
Dorsal Raphe Nucleus/*metabolism
Potassium Channels, Tandem Pore Domain/*metabolism
Serotonergic Neurons/*metabolism
Animals ; Electrophysiology ; Female ; Humans ; Male ; Melatonin/metabolism ; Photoperiod ; Potassium Channels, Tandem Pore Domain/genetics ; Receptors, Melatonin/metabolism ; Serotonin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification.
Autorzy:
Dionisi M; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Ruffinatti FA; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Riva B; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Lim D; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Canta A; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Meregalli C; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Fumagalli G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Monza L; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Ferrer-Montiel A; Biología Molecular y Celular, Universidad Miguel Hernández de Elche, 03202 Elche (Alicante), Spain.
Fernandez-Carvajal A; Biología Molecular y Celular, Universidad Miguel Hernández de Elche, 03202 Elche (Alicante), Spain.
Cavaletti G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Genazzani AA; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Distasi C; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 28; Vol. 21 (19). Date of Electronic Publication: 2020 Sep 28.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*adverse effects
Ganglia, Spinal/*drug effects
Neurons/*drug effects
Oxaliplatin/*adverse effects
Peripheral Nervous System Diseases/*genetics
Potassium Channels, Tandem Pore Domain/*genetics
Sodium-Hydrogen Exchanger 1/*genetics
Action Potentials/drug effects ; Action Potentials/physiology ; Amiloride/pharmacology ; Animals ; Capsaicin/pharmacology ; Epithelial Sodium Channel Blockers/pharmacology ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/pathology ; Humans ; Hydrogen-Ion Concentration/drug effects ; Male ; Mice ; Mice, Inbred BALB C ; Models, Biological ; Neurons/metabolism ; Neurons/pathology ; Patch-Clamp Techniques ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/metabolism ; Peripheral Nervous System Diseases/pathology ; Potassium Channels, Tandem Pore Domain/agonists ; Potassium Channels, Tandem Pore Domain/metabolism ; Primary Cell Culture ; Sodium-Hydrogen Exchanger 1/antagonists & inhibitors ; Sodium-Hydrogen Exchanger 1/metabolism ; Transcriptional Activation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Proteomic Analysis of KCNK3 Loss of Expression Identified Dysregulated Pathways in Pulmonary Vascular Cells.
Autorzy:
Le Ribeuz H; Faculté de Médecine, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, 92350 Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France.
Dumont F; UMS Ingénierie et Plateformes au Service de l'Innovation Thérapeutique, Université Paris-Saclay, 92290 Châtenay-Malabry, France.
Ruellou G; UMS Ingénierie et Plateformes au Service de l'Innovation Thérapeutique, Université Paris-Saclay, 92290 Châtenay-Malabry, France.
Lambert M; Faculté de Médecine, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, 92350 Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France.
Balliau T; PAPPSO-GQE-Le Moulon, INRAE, CNRS, AgroParisTech, Université Paris-Saclay, 91190 Gif-sur-Yvette, France.
Quatredeniers M; Faculté de Médecine, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, 92350 Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France.
Girerd B; Faculté de Médecine, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, 92350 Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France.
Cohen-Kaminsky S; Faculté de Médecine, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, 92350 Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France.
Mercier O; Faculté de Médecine, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, 92350 Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France.
Yen-Nicolaÿ S; UMS Ingénierie et Plateformes au Service de l'Innovation Thérapeutique, Université Paris-Saclay, 92290 Châtenay-Malabry, France.
Humbert M; Faculté de Médecine, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, 92350 Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France.
Montani D; Faculté de Médecine, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, 92350 Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France.
Capuano V; Faculté de Médecine, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, 92350 Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France.
Antigny F; Faculté de Médecine, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, 92350 Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 07; Vol. 21 (19). Date of Electronic Publication: 2020 Oct 07.
Typ publikacji:
Journal Article
MeSH Terms:
Proteome*
Proteomics*/methods
Pulmonary Artery*/cytology
Pulmonary Artery*/metabolism
Signal Transduction*
Endothelial Cells/*metabolism
Myocytes, Smooth Muscle/*metabolism
Nerve Tissue Proteins/*metabolism
Potassium Channels, Tandem Pore Domain/*metabolism
Biomarkers ; Cells, Cultured ; Computational Biology/methods ; Gene Expression Regulation ; Gene Knockdown Techniques ; Humans ; Molecular Sequence Annotation ; Nerve Tissue Proteins/genetics ; Potassium Channels, Tandem Pore Domain/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression.
Autorzy:
Le Ribeuz H; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999 « Hypertension pulmonaire : Physiopathologie et Innovation Thérapeutique », Hôpital Marie Lannelongue, Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Courboulin A; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999 « Hypertension pulmonaire : Physiopathologie et Innovation Thérapeutique », Hôpital Marie Lannelongue, Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Ghigna MR; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999 « Hypertension pulmonaire : Physiopathologie et Innovation Thérapeutique », Hôpital Marie Lannelongue, Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Lambert M; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999 « Hypertension pulmonaire : Physiopathologie et Innovation Thérapeutique », Hôpital Marie Lannelongue, Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Hautefort A; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999 « Hypertension pulmonaire : Physiopathologie et Innovation Thérapeutique », Hôpital Marie Lannelongue, Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Humbert M; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999 « Hypertension pulmonaire : Physiopathologie et Innovation Thérapeutique », Hôpital Marie Lannelongue, Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Montani D; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999 « Hypertension pulmonaire : Physiopathologie et Innovation Thérapeutique », Hôpital Marie Lannelongue, Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Cohen-Kaminsky S; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999 « Hypertension pulmonaire : Physiopathologie et Innovation Thérapeutique », Hôpital Marie Lannelongue, Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Perros F; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999 « Hypertension pulmonaire : Physiopathologie et Innovation Thérapeutique », Hôpital Marie Lannelongue, Le Plessis-Robinson, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Antigny F; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France. .; INSERM UMR_S 999 « Hypertension pulmonaire : Physiopathologie et Innovation Thérapeutique », Hôpital Marie Lannelongue, Le Plessis-Robinson, France. .; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France. .
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Źródło:
Respiratory research [Respir Res] 2020 Jul 16; Vol. 21 (1), pp. 186. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji:
Journal Article
MeSH Terms:
Arterial Pressure*
Antagomirs/*administration & dosage
MicroRNAs/*antagonists & inhibitors
Monosaccharide Transport Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
Potassium Channels, Tandem Pore Domain/*metabolism
Pulmonary Arterial Hypertension/*prevention & control
Pulmonary Artery/*metabolism
Administration, Inhalation ; Animals ; Antagomirs/genetics ; Cell Proliferation ; Cells, Cultured ; Disease Models, Animal ; Gene Expression Regulation ; Humans ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Monocrotaline ; Monosaccharide Transport Proteins/genetics ; Nerve Tissue Proteins/genetics ; Potassium Channels, Tandem Pore Domain/genetics ; Pulmonary Arterial Hypertension/genetics ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Arterial Hypertension/physiopathology ; Pulmonary Artery/physiopathology ; Rats, Wistar ; Signal Transduction ; Vascular Remodeling
Czasopismo naukowe
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